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heir average age was 22 and 77% had artery disease. What are your genes doing to your heart? That's what doctors found in 1953 when they examined the hearts of young US soldiers killed in the Korean War. Heart disease doesn't start at 60. It starts decades earlier, quietly. In this episode I go gene by gene through the heart, artery and blood pressure genes on a DNA test: APOE, LPA, PON1, F5 (factor V Leiden), ACE, FADS1 and FADS2, 9p21, ABCG2 and NOS1. For each one: what the research actually shows, what your result can and can't tell you, and the practical steps that follow. I also cover the blood pressure toolkit, omega-3s and plasmalogens (the work of Dr Dayan Goodenowe), inflammation and immune ageing (Dr Elizabeth Yurth), and why women's heart risk changes at menopause. Find out what your own genes say with my DNA Blueprint Package: https://lisatamati.com/dna Available in New Zealand, Australia and the USA. Chapters 0:00 Heart disease at 22 0:43 Heart disease starts decades early 5:57 What a gene test can and can't tell you about your heart 9:20 APOE: the cholesterol transporter 12:24 LPA: the cholesterol particle you can't diet away 17:04 PON1: your HDL's bodyguard 19:18 F5: your clotting gene 22:19 ACE: blood pressure and saturated fat 25:53 Your blood pressure toolkit 28:37 FADS1 and FADS2: making your own omega-3s 35:43 9p21: the heart disease hotspot 38:47 ABCG2: uric acid 41:54 NOS1: nitric oxide 44:07 Inflammation: the fire in the artery wall 48:28 Women's hearts 50:09 Putting it all together 52:54 The long game 54:00 Your next step Key research mentioned Enos et al., JAMA, 1953 (Korean War autopsies) McGill et al., PDAY, American Journal of Clinical Nutrition, 2000 Fernández-Friera et al., PESA study, Circulation, 2015 Cohen, Hobbs et al., PCSK9, New England Journal of Medicine, 2006 Yusuf et al., INTERHEART, The Lancet, 2004 Khera et al., genetic risk and healthy lifestyle, New England Journal of Medicine, 2016 Bennet et al., APOE and coronary risk, JAMA, 2007 Kamstrup et al., Lp(a), JAMA, 2009; Clarke et al., New England Journal of Medicine, 2009 Bhattacharyya et al., PON1, JAMA, 2008 Bertina et al., factor V Leiden, Nature, 1994; ESTHER study, Circulation, 2007 Schüler et al., ACE rs4343 and saturated fat, Journal of the American Heart Association, 2017 Neal et al., Salt Substitute and Stroke Study, New England Journal of Medicine, 2021 Edwards et al., exercise and blood pressure, British Journal of Sports Medicine, 2023 Lemaitre et al., FADS and omega-3s (CHARGE), PLoS Genetics, 2011 Helgadottir et al. and McPherson et al., 9p21, Science, 2007; Do et al., PLoS Medicine, 2011 Woodward et al., ABCG2 and uric acid, PNAS, 2009 Kapil et al., dietary nitrate and blood pressure, Hypertension, 2015 Ridker et al., CANTOS, New England Journal of Medicine, 2017 Disclosure: I'm a certified Prodrome practitioner and stock Dr Goodenowe's products in my store. I'm also co-founder of Aevum Labs, which makes Re:juvenate Pro (scientific advisor Dr Elizabeth Yurth). More from me Watch the full video on YouTube: https://www.youtube.com/watch?v=BrlVQhShH24 Shop: https://shop.lisatamati.com Instagram: https://www.instagram.com/lisatamati/ Educational content only. Genetics shows tendencies and priorities, not diagnoses.

Why can one person drink a flat white at 3pm and sleep soundly, while another lies awake until midnight? Why does one glass of wine turn some people bright red? A lot of it comes down to your genes. In this solo episode, I break down the caffeine and alcohol genes I look at in my clients' myDNA reports, what your results can and can't tell you, and the simple changes that follow. In this episode: - How CYP1A2 shapes how long caffeine hangs around, and why your cut-off time matters - What the research shows about caffeine, genetics and athletic performance - ADORA2A, and why some people feel caffeine far more strongly than others - The ALDH2 variant behind the alcohol flush, and why it matters for more than a red face - The ripple effects: vitamin B1, REM sleep, APOE, and the unfiltered coffee and cholesterol link - Why genetics loads the gun, and environment pulls the trigger Find out what your genes say with my DNA Blueprint Package, available in New Zealand, Australia and the USA: genetics, DNA test, nutrigenomics, myDNA, caffeine, coffee, alcohol, alcohol flush, red face after drinking, ALDH2, CYP1A2, ADORA2A, APOE, caffeine metabolism, sleep, REM sleep, thiamine, vitamin B1, cholesterol, longevity, personalised health, functional medicine, Lisa Tamati, Pushing the Limits More on thiamine: my full interview with Elliot Overton https://www.youtube.com/watch?v=8qwb_XmDqqk Chapters: 0:00 Same coffee, different genes 0:18 Why blanket health advice fails 1:00 Your caffeine gene: CYP1A2 2:48 Caffeine, sleep and the cut-off 3:27 Caffeine and athletic performance 4:34 ADORA2A: how strongly you feel caffeine 5:35 Alcohol and the ALDH2 gene 7:45 Ripple effects: B1, sleep, APOE and coffee 10:25 Genes load the gun 11:14 Your next step Educational content only. Genetics shows tendencies and priorities, not diagnoses.

I ran 70,000km across the world's toughest deserts to lose weight, and I got heavier, more inflamed and sicker every year. I assumed the problem was discipline. It took one genetic test to show me it never was. In this solo episode I make the case that your DNA is the single most valuable test you will ever do. Not because it tells you the most, but because it is the only test whose result is still true in fifty years. Your bloods reflect the last few weeks. Your microbiome shifts with every trip and every course of antibiotics. Your hormones move across the month and the decade. Your DNA does not move at all. I go through all eight areas a comprehensive genetic panel covers, what you actually learn from each one, and why a variant is a tendency rather than a verdict. IN THIS EPISODE My own results, and the cascade that explains twenty-five years of getting it wrong Why genetics is different from every other test you will ever do Genetics loads the gun, environment pulls the trigger: what that actually means in practice The single-gene trap, and why the MTHFR obsession has it upside down Digestion, energy, hormones, stress and cognition, inflammation, athletic performance, DNA repair and detoxification, one at a time The difference between nutritional dosing and nutrigenomic dosing, and why more vitamin D was not working for me Why genetics alone is not enough, and what has to sit alongside it Why it is almost never discipline THE DNA BLUEPRINT PACKAGE Practitioner-only genetic testing, ninety-two genes and a hundred and thirteen variants across a report of roughly a hundred and twenty-one pages, read by me alongside a full Cell Blueprint assessment and turned into a complete personal health programme in a ninety-minute one-on-one. Available throughout New Zealand. Australia coming soon. https://www.lisatamati.com/dna/ GO DEEPER Dr Sam Shay on methylation, inflammation and exercise-induced obesity: https://www.lisatamati.com/podcast--dr-sam-shay_1/ Dr Mansoor Mohammed on how your variants change what you eat and how you train: https://www.lisatamati.com/podcast-mansoor-mohammed/ Read the long-form article: https://www.lisatamati.com/blog/ ALSO FROM LISA Re:juvenate Pro, the foundational immune ageing formula from Aevum Labs: https://shop.lisatamati.com/pages/rejuvenate Re:NRG, our next-generation NAD support, is coming. Join the waitlist for first access: https://shop.lisatamati.com/pages/nad-next-gen-waitlist Weekly longevity insights, free: https://www.lisatamati.com/lisa Questions or feedback: [email protected] Pushing the Limits is hosted by Lisa Tamati, genetics practitioner, co-founder and Chief Science Officer of Aevum Labs, and former professional ultra-endurance athlete. Author of three books and one audiobook.

Your Immune Age Is Lying To You. Here's How To Read Your Blood And Fix It. How old is your immune system, really? It's probably not the same age as you are — and that gap may be the single biggest hidden driver of how well you age, how fast you recover, and how long you stay healthy. In this episode I break down what actually happens to your immune system as the years tick over — immunosenescence (the immune system getting weaker) and inflammaging (the silent, smouldering inflammation that never switches off) — and why almost every disease of ageing sits somewhere on that spectrum. Then I get practical. I'll show you how to measure your immune age from a standard blood test you can get anywhere in the world, using seven scientifically validated ratios (NLR, PLR, MLR, LMR, SII, PIV and ELR) synthesised into a single Immune Resilience Index. We cover the cutting-edge science from Dr David Furman's 1000 Immunomes Project and the iAge inflammatory clock, the TRIIM and TRIIM-X thymus-regeneration trials, the gut-immune connection (70% of your immune cells live in your gut), the cytokines of ageing (IL-6, TNF-alpha, IL-1 beta, NF-kB and IL-10), and how our Re:juvenate Pro formulation was built to target exactly these pathways. If you want to stop guessing and start tracking the system that runs your healthspan, this one's for you RELATED EPISODES — WATCH THESE NEXT Dr David Furman | The 1000 Immunomes Project and the inflammatory clock of aging: https://www.youtube.com/watch?v=HFOSqEY7CNY Dr Rod Claycomb | Colostrum, immune proteins and immune resilience: https://www.youtube.com/watch?v=VyOfcx9gvbE Aevum Labs panel | Peter Lehrke, medical herbalist Mike Eyres and Dr Rod Claycomb: https://www.youtube.com/watch?v=EstwHB3p3nI Dr Elizabeth Yurth | Immune aging and how to slow it: https://www.youtube.com/watch?v=h_-_rFXcBIA THE SCIENCE + RE:JUVENATE PRO Re:juvenate Pro at Aevum Labs: https://aevumlabs.co.nz/products/re-juvenate Aevum Labs: https://www.aevumlabs.co.nz 🌐 Website: https://www.lisatamati.com 🛒 Supplements: https://shop.lisatamati.com 🎙️ Podcast: https://www.lisatamati.com/podcast 📧 Contact: [email protected]

The link between micronutrients and mental health is one of the most overlooked stories in modern medicine, and Professor Julia Rucklidge has spent more than two decades proving it matters. In this episode of Pushing the Limits, she shares the research on micronutrients and mental health that has challenged psychiatry's drug-first model, showing that broad-spectrum vitamins and minerals can treat ADHD, depression and anxiety, often as effectively as medication and without the side effects. If you have ever wondered how deeply micronutrients and mental health are connected, this conversation will change how you think about your brain, your mood and the food you eat every day. Professor Julia Rucklidge is a clinical psychologist at the University of Canterbury and Director of Te Puna Toiora, the Mental Health and Nutrition Research Lab. She is co-author, with Bonnie Kaplan, of The Better Brain, and her work has been published in leading psychiatry journals and viewed by millions through her TEDx talk. She came into this field as a sceptic, trained to believe that nutrition was irrelevant to the brain, and changed her mind only when the evidence became impossible to ignore. In this conversation, Julia explains what her clinical trials actually found, and why 60 to 80 percent of people respond to a broad-spectrum approach once you move past the noise of a blinded study. We talk about why feeding the whole system beats chasing a single nutrient, what the biomarkers reveal about inflammation, methylation and the microbiome, and why the RDAs were never designed to support an optimally functioning brain. She makes the case that the recommended daily allowances we rely on were built to prevent deficiency diseases, not to help the brain thrive, and that this gap matters enormously for anyone struggling with their mental health. We also explore the bigger forces at play: depleted soils and what modern agriculture has done to the nutrient density of our food, the rise of ultra-processed food and why Julia calls it the cigarette of the twenty-first century, and the antidepressant withdrawal that so many people are never warned about. She shares her frustration with New Zealand's outdated supplement regulations, where a product can be effectively banned for containing a fraction too much of a nutrient, and a distributor can be threatened with serious penalties for selling something that genuinely works. Most of all, this is a hopeful conversation. It is about taking back control of your health through the food on your plate, understanding the real connection between what you eat and how you feel, and recognising that small, consistent changes can have a profound effect on the brain. Whether you are a parent navigating a child's behaviour, someone managing your own mental health, or simply curious about the science of nutrition and the brain, this episode will give you a new lens on what is possible. If you have ever been told that nutrition is irrelevant to your brain, this episode is for you. Resources and mentions: The Better Brain by Bonnie Kaplan and Julia Rucklidge What Your Food Ate by David Montgomery and Anne Biklé Te Puna Toiora, Mental Health and Nutrition Research Lab, University of Canterbury Biography:    09:26     Claude responded: Professor Julia Rucklidge is a clinical psychologist at the University of Canterbury and Director of Te Puna Toiora, the Mental Health and Nutrition Research L… div]:bg-bg-000/50 [&_pre>div]:border-0.5 [&_pre>div]:border-border-400 [&_.ignore-pre-bg>div]:bg-transparent [&_.standard-markdown_:is(p,blockquote,h1,h2,h3,h4,h5,h6)]:pl-2 [&_.standard-markdown_:is(p,blockquote,ul,ol,h1,h2,h3,h4,h5,h6)]:pr-8 [&_.progressive-markdown_:is(p,blockquote,h1,h2,h3,h4,h5,h6)]:pl-2 [&_.progressive-markdown_:is(p,blockquote,ul,ol,h1,h2,h3,h4,h5,h6)]:pr-8"> _*]:min-w-0 gap-3 standard-markdown"> Professor Julia Rucklidge is a clinical psychologist at the University of Canterbury and Director of Te Puna Toiora, the Mental Health and Nutrition Research Lab. One of the world's leading researchers in nutritional psychiatry, she has spent more than two decades running placebo-controlled trials showing that broad-spectrum micronutrients can treat ADHD, depression, anxiety and stress, often as effectively as medication and without the side effects. She is co-author, with Bonnie Kaplan, of The Better Brain, and her TEDx talk on nutrition and mental health has been viewed millions of times. Based in Christchurch, New Zealand, she is on a mission to put nutrition where she argues it belongs: as a serious, evidence-based part of how we treat and prevent mental illness.

What if there was an exogenous ketone that didn't go through the liver, didn't cause the GI distress of other ketones, and delivered bioidentical BHB directly to your cells? In this episode, Lisa sits down with Mike Chesne, founder of Tecton and retired US Army Special Forces combat medic, who spent 25 years in special operations before developing R3HBG — a patented ketone molecule that's categorically different from everything else on the market. Mike's journey from battlefield medicine to biotech is extraordinary. After suffering multiple traumatic brain injuries from IED blasts during nearly three years of combat, he went through brain injury rehabilitation and discovered the neuroprotective potential of ketones. He asked one question that changed everything: "If I had been in ketosis when I got blown up, how much better would my outcome have been?" That question led him to Oxford University, to Dr Kieran Clarke's lab, and eventually to designing his own molecule — drawing it on a napkin and spending over a decade turning it into a manufactured, FDA-reviewed product. In this deep-dive episode we cover: Mike's military career and the brain injuries that changed his path The DARPA project that spent $10 million searching for a supplement to boost performance and cognition by 30% Why the brain in Alzheimer's and TBI can't access glucose but can still take up ketones R3HBG explained: how lipase (not alcohol dehydrogenase) breaks it down, and why that matters The differences between BHB salts, R-1,3-butanediol, the original ketone ester, and R3HBG The NLRP3 inflammasome and how BHB blocks the inflammatory cascade driving neurodegeneration HDAC inhibition and how BHB switches on your body's own antioxidant and longevity genes NDI #1354 and what FDA New Dietary Ingredient acceptance means The GLP-1 agonist connection for weight management and metabolic health Therapeutic dosing for cognition, endurance, and recovery Mike's vision to license R3HBG to every ketone company willing to use it Lisa's experience using ketones with her mother's brain injury and cancer recovery This is the most comprehensive ketone science episode we've ever produced. TECTON KETONES: Use this link for a discount https://tectonketones.com/discount/TAMATI While you're optimising your brain and metabolic health, give your body foundational support with Re:juvenate Pro, my advanced cellular health and longevity formula (https://shop.lisatamati.com/pages/rejuvenate), and explore my full curated range of anti-aging and longevity supplements at shop.lisatamati.com. CONNECT WITH LISA Website: lisatamati.com Shop: shop.lisatamati.com Newsletter: www.lisatamati.com/lisa Podcast: https://www.lisatamati.com/ptl-podcast/ Books: https://shop.lisatamati.com/collections/books Pushing the Limits is brought to you by Lisa Tamati and the team at lisatamati.com.

What if the reason you're not getting better isn't about what you're putting in — but what you can't get out? In this episode I sit down with Tash Simons from INUSpheresis Perth — the first clinic in Australia and the Southern Hemisphere to offer this advanced blood filtration therapy. We go deep into how double filtration plasmapheresis works, the two specialised filters (TKM58 and INUS 30), and the science behind removing autoantibodies, inflammatory cytokines, heavy metals, microplastics, PCBs, and oxidised LDL directly from your blood — without involving your kidneys or liver. We cover the clinical research across long COVID, ME/CFS, autoimmune conditions, Lyme disease, Alzheimer's, and cardiovascular risk including Lp(a) — one of the hardest lipid markers to shift. Tash shares the personal story of how a family member's chronic fatigue led her and Dr Robbie Simons to discover this therapy in Vienna, and the journey to bring it to Perth — from TGA registration and insurance approvals to Swiss certification and over 100 treatments completed. If you're dealing with a chronic condition that won't budge, carrying a toxic load, or thinking about longevity from a subtractive medicine perspective — this one's for you. Book a consult or submit a new patient form at inuspheresisperth.com.au Check out my supplement store at shop.lisatamati.com Rejuvenate Pro at shop.lisatamati.com/pages/rejuvenate My books at shop.lisatamati.com/collections/books Sign up for my newsletter at www.lisatamati.com/lisa Listen to more episodes at www.lisatamati.com/ptl-podcast/ div]:bg-bg-000/50 [&_pre>div]:border-0.5 [&_pre>div]:border-border-400 [&_.ignore-pre-bg>div]:bg-transparent [&_.standard-markdown_:is(p,blockquote,h1,h2,h3,h4,h5,h6)]:pl-2 [&_.standard-markdown_:is(p,blockquote,ul,ol,h1,h2,h3,h4,h5,h6)]:pr-8 [&_.progressive-markdown_:is(p,blockquote,h1,h2,h3,h4,h5,h6)]:pl-2 [&_.progressive-markdown_:is(p,blockquote,ul,ol,h1,h2,h3,h4,h5,h6)]:pr-8"> _*]:min-w-0 gap-3 standard-markdown"> This episode is also brought to you by Rejuvenate Pro from Aevum Labs. If INUSpheresis is about taking the bad stuff out, Rejuvenate Pro is about protecting what stays behind. Featuring kawakawa, carnosic acid, Immunel colostrum extract and IDP (Immune Defense Protein), it targets the chronic systemic inflammation that silently drives aging. It's the first supplement in every protocol I build for my clients — and it should be in yours. Shop now at shop.lisatamati.com/pages/rejuvenate         ━━━━━━━━━━━━━━━━━━━  🌐 Website: https://www.lisatamati.com 🛒 Supplements: https://shop.lisatamati.com  📧 Contact: [email protected]  ━━━━━━━━━━━━━━━━━━━━

Could a simple mineral deficiency be driving mitochondrial dysfunction in autism? In this episode I sit down with Melissa Atchley from MitoSynergy to hear her personal story of using BioCopper1 with her son on the autism spectrum — and the changes she saw that no one expected. I break down the science behind it: Dr Richard Frye's research showing Complex IV dysfunction in children with ASD, the brand new April 2026 Science Advances paper linking copper deficiency directly to ASD-like behaviours through mitochondrial damage and impaired myelination, and why the type of copper matters — Cu1+ vs Cu2+ — more than most people realise. We also cover MitoSynergy's new MitoActivator MAX (4x the strength of the standard formula), the hair greying reversal angle, athletic performance benefits, and practical dosing guidance. If you or someone you love is navigating autism, fatigue, grey hair, or just wants to understand why copper might be the most overlooked mineral in health — this one is worth your time. Get yours in my shop: https://shop.lisatamati.com/products/mitoactivator-max-max-strength-biocopper1-supplement-60-capsmitosynergy-mitoactivator-max?_pos=2&_sid=5c471c21c&_ss=r   Or use code LisaTamati at Mitosynergy.com for your discount

These two doctors are building a clinic where the most advanced longevity therapies have no limits. Dr. Alexander Grinberg (Infinity Epigenetics, San Francisco) and Dr. Dave Jenkins (Bredesen-trained, 40+ years clinical experience) are combining peptide therapy, regenerative medicine, and personalised protocols at a level most people don't know exists. From Klotho protein restoring cognitive function in head injury patients to mitochondrial peptides that can rescue dying cells — this conversation covers the cutting edge of what's actually possible right now. About the Guests Dr. Alexander Grinberg MD is a physician, immunologist, and peptide therapy specialist practicing in San Francisco. He holds a fellowship from the Moscow Immunology Institute and consults internationally on advanced customised longevity protocols. He runs Infinity Epigenetics and teaches physicians in high-end integration of peptides, regenerative medicine, and genetic therapies. Dr. Dave Jenkins is a New Zealand-trained physician with 40+ years of clinical experience specialising in metabolic and neurological health. He is Bredesen Protocol (ReCODE) trained and runs a longevity clinic in Bali. He co-developed a Type 2 Diabetes reversal program now being published and reviewed by NZ's top diabetic specialists. In this episode Why Klotho protein may be one of the most powerful longevity interventions available — and the different delivery forms (protein injection, peptide fragments, gene therapy) Dr. Dave's clinical Klotho results: a doctor with chronic head injury returning to practice, and his own memory score jumping from the 66th to the 97th percentile in six weeks How mitochondrial peptides (MOTS-c, SS-31, Humanin) work and why dosing wrong can be dangerous — especially in autoimmune and cancer history cases The case for micro-dosing peptides and why skin testing should come first Personalised medicine taken to its extreme: harvesting a patient's own cells, expanding them in culture, and running accelerated longevity and cancer resilience tests before any intervention Why peptide purity and sourcing is a serious safety concern — and what the clinic will do differently The vision for a Pacific Island longevity clinic offering therapies unavailable in the US, EU, NZ, or Australia — with a social impact mission to address metabolic disease in local populations Off-label repurposed drugs for cancer (metformin, ivermectin, doxycycline, mebendazole) and why the regulatory environment matters How custom peptides designed from a patient's own genome could replace pharmaceuticals entirely Resources mentioned Infinity Epigenetics — infinityepigenetics.com Dr. Dave Jenkins —  🌐 https://youngerbyscience.com/ 🌐 https://theendofalzheimers.com

Your cells start failing at 35. Dr Sandra Kaufmann reveals the 7 systems breaking down — and how to stop it. Your cells start failing at 35. Dr Sandra Kaufmann reveals the 7 systems breaking down — and how to stop it. 👉 FREE Longevity Cheat Sheet — subscribe to my weekly newsletter: https://www.lisatamati.com/lisa/   Description: Your cells start failing at 35. Dr Sandra Kaufmann reveals the 7 systems breaking down — and how to stop it. Dr Sandra Kaufmann is a cell biologist, physician, and creator of the Kaufmann Protocol — the first comprehensive rating system for anti-aging supplements. In this episode she shares the off-label drugs, supplement stacks, and cellular strategies she uses daily to slow aging at the molecular level. We go deep on mast cell activation and its connection to aneurysms and heart attacks, why NAD infusions may be doing more harm than good, the three sirtuins you need to prioritise after 40, why she takes 70 supplements and 13 medications at low doses, and the SGLT2 inhibitor drugs that are regrowing healthy heart cells by clearing senescent zombie cells. This is one of the most important longevity conversations I have had on the show. ⏱️ TIMESTAMPS: 0:00 - Teaser: Senolytic drugs that regrow healthy heart cells 0:20 - Welcome and intro to Dr Sandra Kaufmann 1:38 - Sandra's background: cell biologist to longevity expert 3:14 - The Post-it note office and chasing the aging puzzle 8:33 - The Seven Tenets of Aging overview 10:19 - Tenet 3: Sirtuins, AMPK, mTOR, and circadian rhythms 11:54 - Tenet 4: DNA repair, proteostasis, autophagy 13:07 - Deep dive: Mast cells and tissue destruction 14:16 - Mast cells, heart attacks, and aneurysms 17:43 - Mastering the Mast Cell: Sandra's new publication 21:06 - Stress triggers mast cell degranulation 23:04 - Mast cell stabilisers: supplements and drugs 27:17 - Sirtuins 1, 3, and 6: the keys to cellular homeostasis 30:05 - Best activators: pterostilbene, DHM, fucoidan 33:38 - The NAD debate: NMN vs NR vs infusions 36:23 - Why NAD IV infusions are a bad idea 39:06 - Rotating NAD precursors: Sandra's approach 44:52 - NRF2 pathway and why daily glutathione is a mistake 50:05 - 70 supplements and 13 drugs at low synergistic doses 56:50 - Rapamycin: Sandra says no 57:51 - Metformin: 250-500mg not 2000mg 1:00:16 - The Flozins: glucose excretion plus senolytic activity 1:02:32 - Epalrestat: blocking the glucose to fructose conversion 1:04:41 - Sandra's 5 daily eye drops protocol 1:08:13 - Naringenin, nobiletin, and the orange peel stack 1:11:28 - Supplement roundup and the Kaufmann Rating System 1:15:23 - Where to find Dr Sandra Kaufmann   SPONSOR MESSAGE This episode is brought to you by MitoSynergy. If you are looking for next-level mitochondrial support, MitoSynergy delivers bioavailable copper in a patented form that supports energy production at the cellular level. Head to mitosynergy.com/lisaTamati and you will get 10% off your order. And if you have not tried Re:juvenate Pro yet, this is the supplement I formulated with my biotech company Aevum Labs. It is not another NAD supplement. Re:juvenate Pro targets immunosenescence, the aging of your immune system, which sits upstream of so many of the problems Sandra and I discussed today. It contains kawakawa, carnosic acid, Immunel colostrum extract, and Immune Defense Protein working across multiple pathways including NRF2 activation, gut barrier support, and immune modulation. It is the first thing I put in every client protocol and it is what I give my mum every single day. You can grab it at    https://shop.lisatamati.com/pages/rejuvenate   🔗 LINKS MENTIONED IN THIS EPISODE: Website: kaufmannprotocol. Website: kaufmannprotocol.com Clinical practice: kaufmannlongevity.com Instagram: instagram.com/kaufmannantiaging Books: amazon.com/stores/Dr-Sandra-Charlotte-Kaufmann/author/B07BDL1WV8 E-treatise: Mastering the Mast Cell (search Amazon) Club Exosome: quarterly in Las Vegas with Steve McCain  ━━━━━━━━━━━━━━━━━━━━ 🌐 Website: https://www.lisatamati.com 🛒 Supplements: https://shop.lisatamati.com 🎙️ Podcast: https://www.lisatamati.com/podcast 📧 Contact: [email protected] ━━━━━━━━━━━━━━━━━━━━ About Lisa Tamati: Longevity specialist, functional health practitioner, co-founder of Aevum Labs (home of Rejuvenate Pro), and host of Pushing The Limits — a globally top-200-ranked health podcast. Author of 4 books.

div]:bg-bg-000/50 [&_pre>div]:border-0.5 [&_pre>div]:border-border-400 [&_.ignore-pre-bg>div]:bg-transparent [&_.standard-markdown_:is(p,blockquote,h1,h2,h3,h4,h5,h6)]:pl-2 [&_.standard-markdown_:is(p,blockquote,ul,ol,h1,h2,h3,h4,h5,h6)]:pr-8 [&_.progressive-markdown_:is(p,blockquote,h1,h2,h3,h4,h5,h6)]:pl-2 [&_.progressive-markdown_:is(p,blockquote,ul,ol,h1,h2,h3,h4,h5,h6)]:pr-8"> _*]:min-w-0 gap-3 standard-markdown"> Your immune system isn't just fighting off colds. It's the foundational system that influences all 14 hallmarks of aging — and when it declines, everything downstream accelerates. In this episode, I sit down with Courtney Van Bussum, COO of Longevity Launch Labs, to dive deep into immunosenescence — the aging of the immune system — and why it starts far earlier than most people realise. We unpack what Stanford's landmark 1000 Immunomes Project revealed about the real driver of biological aging, why your supplement stack might be missing the most important piece, and how we built Re:juvenate Pro (Cell Restore in the US) to target immune aging at its root. We get into the fire station analogy that makes the immune system finally make sense, why 70-80% of your immune system lives in your gut and what that means for barrier health, the science behind four synergistic ingredients — Immune Defense Protein, Immunel colostrum extract, carnosic acid from NZ rosemary, and kawakawa — and why standard colostrum supplements aren't cutting it. We also cover why NSAIDs are impairing your recovery, what CXCL9 is and why most practitioners have never heard of it, Isobel's lymphocyte count recovery story, the immune age calculator app, and why "boost your immune system" is the wrong approach — modulation is everything. This is not another colostrum product. This is upstream immune intervention. Links: Shop Re:juvenate Pro (NZ): https://shop.lisatamati.com/pages/rejuvenate Aevum Labs: https://aevumlabs.co.nz Cell Restore (US practitioners): https://aevumlabs.us Cell Restore (US patients): https://ohphealth.com Longevity Launch Labs: https://longevitylaunch.com Lisa's books: https://shop.lisatamati.com/collections/books Longevity newsletter: https://www.lisatamati.com/lisa More episodes: https://www.lisatamati.com/ptl-podcast/

What if you could know 20 YEARS before symptoms appear whether you're heading for Alzheimer's? And what if there was a proven way to reverse early cognitive decline? In this episode, I sit down with my dear friend Dr. Dave Jenkins — the leading Dr. Dale Bredesen Protocol practitioner in the Southern Hemisphere — to unpack the p-Tau 217 blood test revolution and the stunning results from Bredesen's latest randomised controlled trial. Dr. Dave breaks down how a simple finger-prick blood test can now detect the Alzheimer's process with 95% certainty up to TWO DECADES before memory symptoms begin. This isn't diagnosing Alzheimer's — it's diagnosing the process, which means you have 20 years to intervene. We dive into Bredesen's 2024 multi-site RCT showing the ReCODE precision medicine protocol is 6–7x MORE POWERFUL than the best Alzheimer's drug currently available in America (lecanemab) — a drug with devastating side effects including brain bleeds and even death. Dr. Dave shares real clinical insights from his Bali longevity practice including the 30–60 "holes in the roof" driving cognitive decline, cutting-edge peptides (Semax, Selank, Cerebrolysin, Dihexa), bioregulators, and his personal experience with Klotho gene therapy that took his memory scores from the 70th to the 97th percentile in just 6 weeks. This is essential listening for anyone with a family history of Alzheimer's, anyone watching a loved one decline, and anyone who wants to take brain health seriously BEFORE it becomes a crisis. ⏰ CHAPTERS: [to be generated after edit] 🧠 IN THIS EPISODE: ✅ The p-Tau 217 blood test — detect Alzheimer's 20 years early ✅ Bredesen's RCT: 6–7x more powerful than lecanemab ✅ The BrainScan panel: p-Tau 217, NfL, GFAP explained ✅ Why amyloid drugs chase the smoke, not the fire ✅ The 30–60 "holes in the roof" driving cognitive decline ✅ APOE4 genetics — who needs to pay attention ✅ Peptides for brain health (Semax, Selank, Cerebrolysin, Dihexa) ✅ Klotho gene therapy — 70th to 97th percentile memory scores ✅ Dr. Dave's Bali longevity program at Ravivo Resorts ✅ How NZ/AU listeners can access testing remotely 🔗 CONNECT WITH DR. DAVE JENKINS: 🌐 youngerbyscience.com 🌐 endalzheimers.com.au 🔗 RESOURCES MENTIONED: 🧬 BrainScan p-Tau 217 Test — neurocode.com 🧠 Dr. Dale Bredesen / Apollo Health — apollohealthco.com 📄 Bredesen 2025 RCT — apollohealthco.com/rct-2025 💊 EPISODE SPONSOR: MitoSynergy BioCopper1 — Get 10% off at mitosynergy.com/lisatamati The patented copper nicotinate chelate I take daily for mitochondrial ATP production, mental clarity, and sustained focus. 🔗 WORK WITH LISA: 🌐 lisatamati.com 🛒 shop.lisatamati.com 🧬 aevumlabs.co.nz 🎙️ Pushing the Limits Podcast — lisatamati.com/podcast 📧 [email protected] 📱 FOLLOW LISA: Instagram: @lisatamati Facebook: @lisatamati

The global healthcare system is heading for a catastrophic workforce shortage — 10 to 15 million workers short by 2030. In this episode, financial analyst and Tesla expert Cern Basher (@cernbasher) returns to break down how humanoid robots like Tesla's Optimus could be the only scalable solution, why New Zealand is uniquely positioned to lead a healthcare robotics pilot, and what the Terafab chip factory and Digital Optimus mean for the timeline. From fleet learning to the privacy concerns, from Moxy robots already in 25+ US hospitals to Elon Musk's vision of billions of robots powered by space-based AI — this is the conversation that healthcare, tech, and policy leaders need to be having right now. IN THIS EPISODE: The global healthcare workforce crisis — why no recruitment drive can fix it Robots already in hospitals: Moxy's 1M+ deliveries across 25 US hospitals Tesla Optimus: where the technology is right now The three components: physical body, AI brain, and language model Fleet learning explained — 40 robots learn in 6 months what takes a human 25 years Why New Zealand is the ideal proving ground for healthcare robotics Digital Optimus and Macrohard: the software robot that runs businesses Terafab: Tesla's $25B chip factory with SpaceX and xAI This episode is sponsored by MitoSynergy Copper 1+ Most copper supplements use poorly absorbed oxidised forms that can actually increase free radical damage. MitoSynergy's patented BioCopper1 (Cunermuspir) is a copper-niacin chelate that delivers reduced copper (Cu1+) directly to your mitochondria, supporting ATP production at cytochrome c oxidase. I've been personally testing MitoActivator EX and have noticed a real difference in training power and energy output. Try it: https://mitosynergy.com/lisaTamati (10% off with this link) ABOUT CERN BASHER: NZ-born financial analyst and one of the most influential voices on X at the intersection of AI, Bitcoin, Tesla, and macroeconomics. Follow Cern: @cernbasher on X and YouTube -------------------------------------------- PTL SIGNAL — AI, Tech, Bitcoin and Markets: https://ptlsignal.com Free founding member access to our AI-powered Financial Document Analyzer — earnings transcripts, annual reports, Fed minutes analysed in 60 seconds. Take control of your health and unlock the secrets to a longer, healthier and more vibrant life: https://www.lisatamati.com/healthspan-hacks-course/ SHOP Longevity Supplements: https://shop.lisatamati.com -------------------------------------------- PODCAST — Pushing The Limits: https://www.lisatamati.com/podcast https://podcasts.apple.com/nz/podcast/pushing-the-limits/id1207975008 https://open.spotify.com/show/6mc5BfQispXYMxd4AaYXYL FOLLOW LISA: Instagram: @lisatamati X/Twitter: @lisaytamati YouTube: @LisaTamati Enquiries: [email protected] Website: www.lisatamati.com Shop: shop.lisatamati.com PTL Signal: ptlsignal.com

🔬 This episode is sponsored by MitoSynergy Copper 1+ Most copper supplements use poorly absorbed oxidised forms that can actually increase free radical damage. MitoSynergy's patented BioCopper1 (Cunermuspir) is a copper-niacin chelate that delivers reduced copper (Cu1+) directly to your mitochondria, supporting ATP production at cytochrome c oxidase. I've been personally testing MitoActivator EX and have noticed a real difference in training power and energy output. 👉 Try it: https://mitosynergy.com/lisaTamati (10% off with this link) -------------------------------------------- New Zealand has a once-in-a-generation opportunity to position itself at the front of the humanoid robotics revolution — but nobody's talking about the real safety, privacy and cybersecurity concerns. In this video I break down why NZ should be aggressively pursuing Tesla and robotics in healthcare, the genuine risks around humanoid robots in personal spaces, and why the countries that get involved early don't just get the economic upside — they get to write the rules. 🎯 IN THIS VIDEO: → Why NZ could transform its economy with robotics in healthcare → The 5 real safety concerns about humanoid robots in personal spaces → Physical safety: the fall problem and force-limiting technology → Cybersecurity: what happens when someone hacks a walking camera → Privacy: the robot secretly sending data to China every 5 minutes → The teleoperation problem — strangers controlling robots in your home → Why there are NO safety standards yet for home robots → How NZ can shape global robotics regulation instead of inheriting it → The healthcare pilot approach: why hospitals first, homes later → First-mover advantage: NZ as the proving ground for humanoid robots 📺 RELATED EPISODES: → AI Just Broke The Economy — Cern Basher Part 1: https://www.youtube.com/watch?v=eh0hKibH6Zs → Tesla's Building A Robot Army — Cern Basher Part 2: https://www.youtube.com/watch?v=eh0hKibH6Zs → Why Tesla, Bitcoin & AI Are Moving Together — Cern Basher: https://www.youtube.com/watch?v=QzRPBLa2_Do&t=9s -------------------------------------------- 🔬 SPONSOR: MitoSynergy Copper 1+ Patented BioCopper1 (Cunermuspir) — delivers reduced copper directly to your mitochondria for ATP production, energy, mental clarity, and healthy ageing. Not your average copper supplement. 👉 https://mitosynergy.com/lisaTamati (10% off) -------------------------------------------- ➡️ Take control of your health & unlock the secrets to a longer, healthier & more vibrant life: https://www.lisatamati.com/healthspan-hacks-course/ 🛒 SHOP Longevity Supplements: https://shop.lisatamati.com Lisa's Ai, Tech, Crypto and Investing Website  www.ptlsignal.com -------------------------------------------- 🎙️ PODCAST — Pushing The Limits: 🎧 https://www.lisatamati.com/podcast 🎧 https://podcasts.apple.com/nz/podcast/pushing-the-limits/id1207975008 🎧 https://open.spotify.com/show/6mc5BfQispXYMxd4AaYXYL 📱 FOLLOW LISA: Instagram: @lisatamati X/Twitter: @lisatamati YouTube: @LisaTamati Facebook: /lisatamatiultrarunner 📧 Enquiries: [email protected] 🌐 Website: www.lisatamati.com 🛒 Shop: shop.lisatamati.com #TeslaOptimus #RobotsInHealthCare #HumanoidRobots #NewZealand

Wall Street veteran and macro investor Jordi Visser spent 30 years managing billions in risk — building turbulence models to predict market crashes before they happened. Then he turned that exact same framework on his own biology. The result? He raised his HRV from the high 20s to the 60s over six years. Not with a protocol. With a system. Jordi is back on Pushing The Limits for round two and this episode covers everything. We go deep on HRV and longevity — what your wearable is actually telling you, why your gut health is the foundation of your HRV, why breathwork beats meditation, why muscle is a signal organ not just a performance tool, and how to use AI as a daily thinking partner to accelerate your health journey. Then we flip to macro. Jordi breaks down why he believes capitalism's 10,000 year bargain between capital and labour officially broke in 2025, why Bitcoin is the architectural blueprint for what comes next, why AI agents cannot operate without crypto infrastructure, and what the Strait of Hormuz crisis means for oil, commodities and your investments right now. We also get into the AI revolution and what it means for ordinary people — why entrepreneurs will beat Google, why you don't need to be technical to benefit from AI, how to build multiple income streams using these tools, and why leaning in now is the most empowering thing you can do for your financial future. This is one of the most wide ranging conversations we have ever had on Pushing The Limits. Health, wealth, technology and the future — all connected by the same framework. Topics covered include heart rate variability, HRV and longevity, resonance frequency breathing, the gut brain vagus nerve axis, muscle and ageing, fermented foods and the microbiome, AI tools for entrepreneurs, Bitcoin 2026, macro investing, the private credit crisis, Strait of Hormuz oil shock, commodities bull market, hardware stocks and why 2008 can never happen again. Find Jordi Visser at visserjhrv.substack.com for his HRV Substack and visserlabs.substack.com for his macro AI and Bitcoin research. His YouTube channel is at youtube.com/@JordiVisserlabs and he heads AI Macro Nexus Research at 22V Research. Find out more about Lisa and her work at lisatamati.com. Shop longevity supplements including Re:juvenate Pro at shop.lisatamati.com. Re:juvenate Pro is Aevum Labs flagship longevity formula targeting immunosenescence, inflammageing, gut health and cellular repair — co-developed with Dr Elizabeth Yurth of the Boulder Longevity Institute. Learn more at aevumlabs.co.nz. Pushing The Limits is available on all major podcast platforms. Subscribe and leave a review if this episode added value to your life. REJUVENATE PRO — AEVUM LABS: Our flagship longevity formula targeting immunosenescence, inflammageing, gut health and cellular repair. Co-developed with Dr Elizabeth Yurth of the Boulder Longevity Institute. NZ made, science backed, no fillers. Shop now: https://shop.lisatamati.com/pages/rejuvenate LONGEVITY SUPPLEMENT STORE: Everything Lisa personally uses and recommends: https://shop.lisatamati.com WORK WITH LISA: Functional health practitioner consultations for complex cases: https://www.lisatamati.com/page/work-with-lisa LISA'S BOOKS: https://www.lisatamati.com/page/books FREE NEWSLETTER AND LONGEVITY CHEAT SHEET: https://www.lisatamati.com/lisa/ WEBSITE: https://www.lisatamati.com PODCAST: https://www.lisatamati.com/podcast CONTACT: [email protected] FOLLOW LISA: Instagram: https://www.instagram.com/lisatamati Facebook: https://www.facebook.com/lisatamati YouTube: https://www.youtube.com/lisatamati X: https://x.com/lisatamati