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Description/Summary:  What if mental health treatment started with changing how the brain connects?  In this episode of Sounds of Science, neuropharmacologist Dr. Allison Feduccia explains how psychedelic‑assisted therapies may quiet rigid brain patterns, open new pathways, and reshape how we treat depression, trauma, and addiction. Show Notes  Psychedelic Studies | Charles River Preclinical MRI In Vitro Imaging Services | Charles River Preclinical Neuroscience CRO Services | Charles River

For this discussion we brought together experts Dr. Matthias Herzler and Dr. Hennicke Kamp from the German Federal Institute for Risk Assessment and Charles River’s Head of Regulatory Affairs Ira Koval to discuss the European Union’s Roadmap for phasing out animal testing for chemical safety assessments. What does the roadmap really say, and what will implementation look like? How can we balance the public’s call for action with their safety? Listen now to find out!

What happens when cutting‑edge science meets one of the most devastating pediatric cancers? In this episode of Sounds of Science, Dr. Aled Edwards discusses how open, collaborative research is helping scientists confront rare and fatal childhood cancers like diffuse intrinsic pontine glioma, and what it means when a potential therapy moves closer to reaching children who urgently need it.    Show Notes  The Disruptors: Meet Aled Oncology In Vivo Imaging Solutions | Charles River Oncology CRO Services | Charles River Open Science: The Parallel Universe | Podcast A Deadly Brain Cancer in Children | Blog

When Andrew Miner’s son James was diagnosed with an ultra-rare YWHAG mutation, the path forward was anything but clear. In this compelling episode of Sounds of Science, Andrew shares his family’s journey, the inspiration behind founding the YWHAG Foundation, and how advancing research is creating new possibilities and renewed hope for families affected by rare diseases. www.ywhagfoundation.org.https://www.criver.com/eureka/ywhag-ultra-rare-mutation-family-hunts-solutions

From hantavirus to Ebola to cyclosporiasis, it’s hard to escape the news about outbreaks of exotic viruses in people. How might these diseases impact or be transmitted by animals? In this episode, which airs July 21, Ken Henderson, PhD, DACLAM, an expert on keeping research mice and rats safe from outside threats, shares his insights into the most up-to-date research on biosecurity.  Show Notes    Pathogen Binder | Charles River  Research Animal Diagnostic Services | Charles River  Research Models and Services | Charles River

What happens when parents refuse to accept a one percent chance? In this episode of Sounds of Science, Piotr and Gosia Kosla share how their daughter Lena’s ultra‑rare diagnosis sparked a global scientific effort, advancing a potential treatment from discovery to an active preclinical toxicology study in just two years. Show Notes    General Toxicology | Charles River Preclinical GLP Toxicology Studies Painting a Picture of Hope to Treat PACS2 | Podcast PACS2 Research Foundation

FOXG1 Research Foundation CEO Nasha Fitter returns to Sounds of Science with extraordinary updates: FDA Fast Track designation, IND clearance, and the first‑ever clinical trial for a FOX G1 gene therapy now within reach. In this episode, hear how science, community, and a mother’s determination are rewriting what’s possible.   Show Notes  Cell and Gene Therapy CDMO Solutions | Charles River Viral Vector Manufacturing \ Charles River AAV Production for Rare Disease Therapies: From Challenge to Solution | Webcast Rare Disease | Charles River Rare Disease Research for Drug Development | Charles River FOX G1: A Mom’s Mission | Podcast

The 3Rs of animal research (Replacement, Reduction, Refinement) are truly a global effort. One of the experts leading this effort is veterinarian Adrian Smith, Secretary of the Norwegian organization Norecopa. Along with Executive Director Global Animal Welfare and Training for Charles River Liz Nunamaker, they share the creation and growth of Norway's National Consensus Platform and Centre for furthering the 3Rs, and how even researchers outside of Norway like Nunamaker benefit from its work.

What if one shot could reverse a meth overdose? In this episode of Sounds of Science, we explore CS1103 - Clear Scientific's breakthrough therapy with FDA Fast Track status that works like Pac-Man to clear toxins fast. Could this change emergency medicine forever? Tune in to find out.  Clear Scientific: Combatting Drug Overdose from Methamphetamine, Fentanyl, and Polydrug | Charles River Podcast IND-Enabling Studies | Charles River Small Molecule Drug Development | Charles River Safety Assessment | Charles River

We are joined by retiring CEO Jim Foster to discuss his 50 year career at Charles River. Through his decades in the industry, Foster has seen it all - from the shift toward new approach methodologies, through mergers and sales and public offerings, to shaping the future of Charles River's culture. Listen now to hear how it all started, how we got here, and where we are heading in the future.

In this episode of Sounds of Science, Lauren and Matt Noonan share their powerful journey following their daughter Jane’s diagnosis with Mowat-Wilson Syndrome. From unexpected medical challenges to finding community and launching their own nonprofit, the OURS Foundation, they discuss how advocacy, collaboration, and emerging research are shaping new hope for families living with rare diseases.  Charles River | ASO Development Charles River | ASO Screening Services Charles River | Rare Disease Charles River | Rare Disease Research for Drug Development Mowat Wilson Foundation

I am joined by Charles River's newest Senior Vice President, Chief Scientific & Innovation Officer Dr. Namandjé Bumpus to discuss her amazing career. From hands on research as Professor and Director of the Department of Pharmacology and Molecular Sciences at Johns Hopkins University School of Medicine, to Chief Scientist and later Principal Deputy Commissioner at the US Food and Drug Administration, Dr. Bumpus has seen every angle of the industry. She joins me to discuss her research, the discipline she learned from her father's boxing gym, and her perspective on the industry today.

Patients who need kidney dialysis live all over the world - even in some of the remotest regions. They need updated equipment, trained healthcare staff, and lots of clean water. Chris Atwater, Director of Technical Operations at the nonprofit Bridge of Life, helps bring hope to these areas. He has traveled to six continents for his life's work, using skills he learned as a United States Marine and the education he acquired for this role. If you are interested in learning more about challenges facing dialysis patients in remote areas, check out this video we made about services in the Australian bush.

When Terry Pirovolakis learned his son had an ultra-rare neurodegenerative disease, SPG50, he refused to accept “no options.” What started as a desperate search for hope became Elpida Therapeutics, a nonprofit driving gene therapy innovation for multiple rare diseases. In this episode, Terry shares the remarkable journey from diagnosis to clinical trials, the power of partnerships, and why urgency matters when every day counts. Show Notes From Mystery to Medicine: The Science Behind a Mother’s Search | PodcastTaking a Customized and Collaborative Approach to Therapeutic Development | PodcastRare Disease Research for Drug Development | Charles RiverRare Disease | Charles RiverDiscovery | Charles RiverBeyond The Diagnosis

What happens when a rare disease diagnosis turns life upside down? In this episode of Sounds of Science, host Mary Parker sits down with Bo Bigelow, Amber Freed, and David Fischer to explore the breakthroughs, challenges, and human stories behind Hao-Fountain Syndrome. From a father’s fight for his daughter Tess to cutting-edge drug repurposing screens, discover how science, advocacy, and community are rewriting the future for families worldwide. Show Notes Rare Disease | Charles River  Vital Science Podcast: Strength in Numbers Rare Disease Research for Drug Development  Foundation for USP-7 Related Diseases  Stronger Every Day Podcast