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Dr. Anna Sitkoff, naturopathic physician and medicinal mushroom researcher, reveals why so many people try high-quality mushroom products and feel nothing. This deep dive explores extraction methods, fruiting body versus mycelium, proper dosing, and the clinical applications of Lion's Mane, Cordyceps, Reishi, and Turkey Tail for immune support, gut-brain health, and neurodegeneration.find her on your socials at:@drannasitkoff @lucidummedicinalsfull episode notes at https://onethingpod.com/sitkoff

Dr. Lara Briden challenges everything you think you know about metabolism, revealing why energy—not weight—is the true marker of metabolic health. This conversation explores how modern life has pushed our physiology into states it was never designed for, and offers a compassionate, science-based approach to understanding your body as a logical system rather than a problem to fix. GUEST INFORMATION: Name: Dr. Lara BridenTitle/Credentials: Naturopathic doctor, author, former evolutionary biology researcher Background: Has peer-reviewed publications and thesis in evolutionary biology, specializes in women's health with focus on centering female physiology as normal mammalian function EPISODE HIGHLIGHTS: Evolutionary Biology Framework Dr. Briden explains how her background in evolutionary biology informs her medical practice, viewing women's bodies as logical systems that make biological sense Menopause as Evolutionary Advantage Discussion of how menopause evolved as a survival advantage, with post-reproductive women being essential for family group survival Debunking the Willpower Myth Challenges the narrative that metabolic issues are about eating too much and exercising too little The Asthma Analogy Explains why telling people to "just lose weight" is like telling someone with asthma to "just breathe better" Environmental Factors Details how environmental toxins, gut microbiome changes, and epigenetics contribute to metabolic dysfunction across species and generations Energy as Metabolic Marker Explains metabolic flexibility and how the body should preferentially burn fat in fasting states Blood Sugar Crashes Discusses how insulin resistance often presents as reactive hypoglycemia rather than high blood sugar Seed Oils Discussion Dr. Briden shares her perspective on high-dose omega-6 oils as metabolically problematic signaling molecules Nervous System and Metabolism Explores how the autonomic nervous system significantly impacts insulin sensitivity and metabolic rate Key Metabolic Nutrients Discuss essential nutrients for metabolic health: magnesium, taurine, choline, inositol, and glycine, historically obtained from organ meats Mitochondria as Masters Fascinating discussion of mitochondria as dynamic cellular powerhouses affected by emotions and social activity Lab Testing Simplified Provides practical lab markers for insulin resistance: ALT levels, ALT to AST ratio, and triglycerides RESOURCES MENTIONED: Metabolism Repair For Women, by Dr. BridenPeriod Repair Manual (previous book) Potential upcoming cookbook collaboration KEY TAKEAWAYS: Metabolism problems often come before weight gain, not after—it's about insulin resistance first Energy levels and satiety between meals are better indicators of metabolic health than body weight Environmental factors including toxins, processed oils, and gut dysfunction are major contributors to metabolic issues The body has a complex system that can't be micromanaged—focus on removing obstacles and supporting overall health Simple lab tests (ALT, triglycerides) can reveal insulin resistance more effectively than complex testing Website: https://www.larabriden.com/ CALL TO ACTION:Subscribe to the One Thing Podcast for more conversations that challenge conventional health wisdom and center biology over blame. Share this episode with someone who's been struggling with metabolic health issues—these insights could be exactly what they need to hear.

After 6 years of hosting The One Thing Podcast and 20 years in clinical practice, I'm thrilled to announce my first group program: The Gut Freedom Intensive. This is a 6-week cohort-based course that brings my one-on-one clinical approach to a small group format. If you've been struggling with IBS, SIBO, Inflammatory Bowel Disease, bloating, or any form of digestive distress, this intensive is designed for you. What You'll Get: 6 weekly live group sessions with mePersonalized roadmap for your specific digestive imbalancesDeep dives into gut immunity, microbiome, food sensitivities, and moreInteractive assignments to identify YOUR root causesGuidance on nutrition, lifestyle, supplements, and functional testingOngoing support throughout the programThis isn't a one-size-fits-all approach. Through guided exercises and assessments, we'll uncover exactly what YOUR gut needs to heal. Course Details: Starts: February 4th, 2026Duration: 6 weeksFormat: Live weekly sessions + comprehensive curriculumLimited to 25 participantsSpecial Listener Discount: Listen to the special announcement where I mention a code that will give a discount of 20% off - good through December 15th, 2025 Enroll at: [Gut Freedom Intensive] Questions? email [email protected] I look forward to guiding you on your journey to gut freedom. Show Notes:🔗 Enroll in Gut Freedom Intensive: [LINK]📅 Course Starts: February 4, 2026 #guthealth #IBS #SIBO #digestivehealth #gutfreedom #functionalmedicine

In this episode, Dr. James Thompson, MD — a board-certified allergist, immunologist, author, and health educator — shares how a 21-day Daniel Fast sparked a life-changing shift toward plant-forward living. After 34 years in medicine, he realized that despite following what he believed was a “healthy” diet, he still required multiple long-term medications for blood pressure, cholesterol, and chronic inflammation. A plant-based lifestyle helped him eliminate medications, improve sleep and joint pain, and even restore vision. Today, Dr. Thompson leads the Healthy Living With a Vision Foundation, delivering accessible nutrition and lifestyle medicine education to underserved communities. His FEARLESS Method (Food, Exercise, Avoid Toxins, Restorative Sleep, Less Stress, Engage Mind, Social Energy, Spirituality) is a practical roadmap for chronic disease prevention and sustainable health. What You’ll Learn How fasting and plant-forward eating triggered Dr. Thompson’s health transformation Why medical education still provides minimal nutrition training How plants impact inflammation, cholesterol, metabolic health, and cognitive resilience The truth about protein needs and nutrient considerations (B12, omega-3s) How to start a plant-forward lifestyle without going “all or nothing” Health disparities in Black communities and why trust in healthcare remains fractured The FEARLESS Wellness pillars and how to apply them Key TopicsPlant-forward nutrition · fasting · inflammation · lifestyle medicine · sleep · stress · chronic disease prevention · community health · spirituality · affordability Time Stamps: 00:00 — Intro: Why nutrition conversations are polarized01:30 — Meet Dr. James Thompson03:11 — How the 21-day Daniel Fast changed everything04:00 — Running, meds, and early health struggles05:23 — The nutrition gap in medical training07:20 — Diving into nutrition education08:00 — Fasting & time-restricted eating10:00 — How plant-forward living improved his health11:20 — Greens, beans, berries & whole foods12:21 — Unexpected vision improvements14:29 — Defining plant-based vs. plant-forward15:20 — Protein myths & amino acid basics18:43 — How much protein you really need20:44 — Key nutrients: B12 & omega-3s24:26 — Getting omegas from plant foods26:04 — Why patients trusted his holistic approach29:51 — Introducing lifestyle medicine in practice32:32 — Reversing chronic conditions through diet34:29 — Planting seeds for long-term change37:13 — Asthma, acne & inflammation stories40:01 — Creating the FEARLESS Method42:45 — The 8 FEARLESS pillars45:16 — Starting small without overwhelm48:25 — Working with the Black community51:34 — Why medical mistrust persists54:00 — COVID-19 & vulnerable populations56:13 — The limits of access without education57:03 — His current work & foundation59:15 — What to buy with $5 for a healthy meal1:00:50 — Spiritual frameworks for hard times1:02:08 — Closing reflections Notable Quotes“Within six months of going plant-based, I no longer needed blood pressure or cholesterol medication.” “Doctors learn to diagnose and prescribe, not prevent.” About Dr. James Thompson, MDDr. Thompson spent over three decades in allergy/immunology and internal medicine before shifting to lifestyle health education. His work focuses on plant-forward nutrition, chronic disease prevention, and equitable community wellness. His book FEARLESS Wellness outlines eight pillars for long-term vitality. Website: FearlessMD21.com Foundation: HealthyLivingWithAVision.org

You can spot a mouth breather from across the room — but what if that simple habit is reshaping your child’s face, disrupting their sleep, and setting the stage for autoimmune disease?In this episode, Dr. Toni Ingram — biological dentist and founder of Flourish Dental Boutique in Dallas — joins us to uncover the powerful link between your mouth and your overall health. We dive into:• The truth about mouth breathing, nitric oxide, and cardiovascular protection• How the oral microbiome drives inflammation and chronic illness• Why dental plaque is a living biofilm — and what that means for disease risk• Natural ways to strengthen teeth and rebalance your microbiome (no fluoride required)• The oral clues behind poor sleep, ADHD-like symptoms, and immune dysfunction Dr. Ingram reveals why your mouth is the gateway to your body — and how small daily practices like tongue scraping, xylitol sprays, and nasal breathing can transform your energy, sleep, and long-term health. ✨ Contest alert: Listen to the end for details on how to win an Oral DNA Microbiome Testing Kit! Follow @drtonyingram on Instagram or visit flourishdentalboutique.com for more. --- Detailed Show Notes Found at: exclusive subtack page: https://adamrinde.substack.com/p/episode-127-dr-toni-engram-the-mouth  Sponsor Spotlight: Feeling stressed, anxious, or restless? Discover how to calm your nervous system with Pulsetto, the vagus nerve stimulation device designed to lower stress and improve sleep—drug free. 👉 Try it here: ⁠⁠https://pulsetto.sjv.io/jed7KM

In this episode of the One Thing podcast, host Dr. Adam Rinde delves into the fascinating world of Tension and Trauma Releasing Exercises (TRE) with Richmond Heath, founder of TRE Australia. Discover how the body's natural tremor response, often suppressed in our culture, can be a powerful tool for healing stress and trauma.  Richmond shares his journey from skepticism to advocacy, revealing how TRE has transformed his understanding of trauma recovery.  Whether you're curious about the science of trauma, the mind-body connection, or seeking practical ways to calm your nervous system, this episode offers profound insights.  Join us as we explore the innate wisdom of our bodies and learn how to harness it for better health and well-being. Bio: Richmond Heath is the founder of TRE Australia and an integrative physiotherapist who has dedicated his career to exploring the body's natural tremor response as a means of recovering from stress and trauma. His work with Tension and Trauma Releasing Exercises (TRE) has been applied in various settings, from war zones to natural disaster recovery efforts, demonstrating the body's innate ability to heal itself.  Time Stamps: 03:44 - Richmond's first TRE experience and immediate physical changes 05:27 - Shift in clinical practice approach with patients 07:09 - Types of tremors and common patterns in TRE 14:23 - The autonomic nervous system and recovery reflex mechanism 20:17 - How the body determines what tension to release 22:01 - Ukraine outreach work with 400+ participants 38:19 - Safety considerations and self-regulation techniques 39:33 - Range of emotions and experiences during TRE 42:34 - Vision for TRE integration in healthcare and schools 46:06 - Online TRE course development and accessibility 47:59 - Closing thoughts on reframing panic attacks as discharge Detailed Show Notes Found at: exclusive subtack page: https://adamrinde.substack.com/p/episode-127-healing-through-tremoring  Sponsor Spotlight: Feeling stressed, anxious, or restless? Discover how to calm your nervous system with Pulsetto, the vagus nerve stimulation device designed to lower stress and improve sleep—drug free. 👉 Try it here: ⁠https://pulsetto.sjv.io/jed7KM

At just 16, Os Aponte was running a martial arts school in Puerto Rico with over a hundred students. Today, he’s a U.S. Army veteran, author, and strength coach known for blending martial arts discipline, neuroscience, and movement mastery into a philosophy of lifelong fitness. In this conversation, Os shares how leading soldiers in the Army shaped his approach to strength, why “less is more” in training, and how neural efficiency—not just muscle size—creates real, lasting power. You’ll also hear how kettlebells, gait mechanics, and breathwork can rewire your body for performance at any age. Whether you’re a coach, athlete, or weekend mover, Os’s story will challenge how you think about fitness and inspire you to see training as a lifelong pursuit of self-mastery. We discuss: How Os became a martial arts instructor at 16 What the military taught him about leadership and physical mastery The difference between strength, conditioning, and fitness Why neurological training beats burnout The power of the Turkish get-up and “leaving one in the tank” How to make your fitness serve your life—not the other way around 💬 Sponsor Spotlight:Feeling stressed, anxious, or restless? Discover how to calm your nervous system with Pulsetto, the vagus nerve stimulation device designed to lower stress and improve sleep—drug free.👉 Try it here: https://pulsetto.sjv.io/jed7KM 📍 Connect with Os: Bird Rock Fit, La Jolla | StrongFirst Workshops | Follow Osvaldo on his website www.ironcoreway.com for insights, tips, andupdates on his upcoming workshops and events. 📘 Book: Iron Core in Four Chambers (coming soon)

Why do we eat when we’re not hungry—especially at night? Willpower isn’t the answer. In this episode, clinical psychologist Dr. Helen McCarthy reveals the Appetite Pendulum—a powerful framework that helps you understand hunger, fullness, and emotional eating without shame. We dig into why evenings are the danger zone, how to tell the difference between hunger and emotion in your body, and how a 10-second Pause Technique can change your relationship with food starting tonight. You’ll also learn the four biggest saboteurs of healthy eating, why GLP-1 medications like Ozempic help some people but aren’t the full solution, and the one small habit change that makes the biggest difference. If you’ve ever struggled with “food noise,” night-time grazing, or the cycle of willpower and regret, this conversation will give you practical, evidence-based tools you can use immediately. About Dr. McCarthy: Dr Helen McCarthy is a Clinical Psychologist, and is the "Appetite Doctor". She developed Appetite Retraining to help people lose weight by re-learning to eat in tune with their body's natural hunger and fullness signals. Helen is an Associate Fellow of the British Psychological Society who has worked as a Clinical Psychologist since 1989.  She has a B.Sc. Honours degree in Experimental Psychology from the University of Durham and a Doctorate in Psychology from the University of Oxford. After leaving Oxford Helen trained as a Clinical Psychologist within the British National Health Service and worked as a Clinical Psychologist in the NHS and then in private practice.  She was a Visiting Research Fellow at the University of Bristol and served as a Faculty Member for the UK Royal College of General Practitioners Leadership in Obesity Programme. She has also served as a member of the Advisory Panel for the UK and International Health Coaches Association. Helen has appeared on ITV and Channel 4 TV channels on programmes dealing with the psychology of weight loss. She says, "What I love most of all, is putting psychology into practice to help people overcome what’s troubling them in their relationship with food". Please support our podcast by visiting our affiliate sponsor: Healthgevity : ⁠⁠Website⁠⁠ Enter: ONETHING for a 10% discount

“There is always a reason for illness. You may not have all your answers today, but that doesn’t mean answers don’t exist. Never give up.” – Dr. Diana Driscoll In this episode, Dr. Diana Driscoll — optometrist, researcher, patient, and founder of POTS Care — takes us inside her groundbreaking journey to uncover the hidden mechanisms of Postural Orthostatic Tachycardia Syndrome (POTS). After years of worsening illness and dismissal by the medical system, Dr. Driscoll combined her medical expertise with relentless patient-driven research. What emerged is now known as the Driscoll Theory, a framework that explores: What drives POTS: high intracranial pressure, vagus nerve dysfunction, neurotransmitter disruption, and systemic vascular irregularities. How to intervene: restoring vagus nerve function, reducing inflammation, supporting acetylcholine activity, and managing oxidative stress. Practical tools: supplements like ParaSym Plus and NAC Max, targeted use of histamine blockers, and non-invasive approaches to improving quality of life. Emotional resilience: how she navigated years of invalidation, supported her sick child, and created POTS Rebels, a community for patients seeking hope and science-backed solutions. This conversation is both deeply personal and highly practical, offering clarity for patients, practitioners, and caregivers searching for answers. 00:00 – 02:00 | Intro & sponsor message (Healthgevity) Healthgevity our sponsor : ⁠Website⁠ Enter: ONETHING for a 10% discount 02:00 – 03:00 | Adam introduces Dr. Driscoll & her personal journey with POTS 03:00 – 08:00 | The turning point: realizing medicine had no answers → “I’m on my own” 08:00 – 13:00 | Discovering high intracranial pressure and what eye patterns reveal 14:00 – 18:00 | The emotional toll & why she built the POTS Rebels community 19:00 – 24:00 | The what: inflammation as the hidden driver of POTS 25:00 – 33:00 | The how: vagus nerve, acetylcholine, nicotine patch experiment, and ParaSym Plus 34:00 – 38:00 | Genetic predisposition, hypermobility, and EDS connections 38:00 – 41:00 | Identifying intracranial pressure symptoms (coat hanger pattern, nausea, insomnia) 41:00 – 44:00 | Framework for healing: vagus support, histamine blockers, antioxidants 45:00 – 48:00 | Take-home: “Never give up. Illness always has a reason.” 49:00 | Closing thoughts & listener call-to-action POTS Care → potscare.com POTS Rebels community → [Patreon link if available] TJ Nutrition (ParaSym Plus, NAC Max) → tjnutrition.com Healthgevity our sponsor : ⁠Website⁠ Enter: ONETHING for a 10% discount

Are you running on autopilot… or carrying silent trauma? Trauma isn’t always dramatic. Sometimes it hides in plain sight...numbness, autopilot living, or the body’s quiet tension. Psychologist and somatic trauma specialist Dr. Shahrzad Jalali calls this silent trauma—the unrecognized emotional wounds that high achievers carry into their careers, relationships, and even their gut health. In this powerful conversation, Dr. Jalali shares: How to spot the difference between everyday stress and unconscious scripts steering your life The body’s biggest “holding zones” for trauma such as the gut, jaw, shoulders, and pelvis A 90-second nightly practice to reclaim emotional autonomy Why your fights aren’t about “the dishes” but about childhood wounds replaying in real time How to honor your family while still choosing yourself Dr. Jalali’s upcoming book, The Fire That Makes Us, blends her personal story of loss with decades of clinical work to show how fire can both burn and forge resilience. ✨ Take a deep breath, press play, and discover how to stop outsourcing your worth—and finally belong to yourself. Related Links Healthgevity our sponsor : Website Enter: ONETHING for a 10% discount https://www.instagram.com/alignremedy/ https://www.facebook.com/people/Align-Remedy/61567336701015/ https://www.linkedin.com/in/shahrzad-jalali-psyd-2b547320/ https://www.amazon.com/Fire-That-Makes-Unveiling-Transformative/dp/B0DWYN5TFM

What if ADHD isn’t about attention at all? In this episode, Dr. Adam Rinde sits down with Dr. Shirley Hershko, a globally recognized ADHD specialist, to dismantle the myths, reveal the hidden faces of ADHD in adults and women, and share practical tools for thriving with a differently wired brain. Whether you’re struggling with focus, overwhelmed by daily life, or simply curious about the real story behind ADHD—this episode will change the way you see yourself or your loved ones. 00:00 – Intro & Podcast Support:You can support the podcast through affiliate sponsors like ⁠⁠⁠⁠⁠Healthgevity⁠⁠⁠⁠⁠ (use code ONETHING for 10% off). 01:04 – ADHD Isn’t About Attention:Dr. Rinde introduces Dr. Shirley Hershko, and challenges what most people believe about ADHD. 02:16 – Episode Overview:What you’ll learn about myths, adult ADHD, diagnosis, trauma, and more. 03:03 – Meet Dr. Shirley Hershko:Her global mission, new book, and vision for ADHD support. 05:59 – Dr. Hershko’s Personal ADHD Journey:How personal experience led her to this work. 08:11 – Myths That Drive Experts Crazy:Why ADHD is not just a focus problem—and the real cost of misunderstanding. 10:02 – Time Blindness & Regulation Issues:Why ADHD is really about time and emotional regulation, not just attention. 12:14 – Diagnosis in the Modern World:Are we over-diagnosing, or finally getting it right? 13:29 – How ADHD Shows Up in Adults:Chronic disorganization, emotional overwhelm, and hidden symptoms. 15:33 – Hidden Symptoms & Gender Differences:How ADHD can look totally different in men vs. women—and why girls are so often missed. 17:26 – Why Women Get Overlooked:Perfectionism, masking, and the struggle behind high performance. 21:43 – The ADHD-Trauma Overlap:How trauma can mimic or worsen ADHD, and the importance of trauma-informed care. 24:38 – ADHD & Relationships:Marriage, friendship, communication, and how to shift from blame to collaboration. 26:59 – Regulation, Sleep & Eating:Why sleep, eating patterns, and lifestyle can be so challenging—and how to manage them. 29:54 – Couples & Executive Function:The dynamic of ADHD in relationships, from frustration to resilience. 31:40 – Getting a Meaningful Diagnosis:Why checklists aren’t enough—Dr. Hershko’s approach to thorough assessment. 33:21 – Medication & Misconceptions:What meds can (and can’t) do for ADHD. 34:45 – The ‘Just the Moment’ Method:Dr. Hershko’s practical system for time management—and why it really works. 37:06 – Hope for the Future of ADHD:Why there’s never been a better time to seek support. 38:26 – Surprising Facts & Under-Discussed Issues:What most people miss about ADHD—and how environment matters. 39:56 – Where to Get Help:How to find an assessment, join the community, and learn more from Dr. Hershko. 42:53 – Wrap-Up & Final Thoughts:How to connect with Dr. Hershko and join the global ADHD conversation. Resources Mentioned: https://www.drshirleyhershko.com/adhd-diagnosis https://did.li/0dSrl If you found this helpful, please like, comment, and subscribe. Share with anyone who might benefit from understanding ADHD more deeply!

How do we move forward when the future is uncertain and the path to healing feels like a rollercoaster? In this episode, host Dr. Adam Rinde sits down with renowned sports and performance psychologist Dr. Haley Perlus to explore the emotional and mental dynamics of healing, resilience, and intentional recovery. Drawing from her decades of experience working with Olympic athletes, business leaders, and wellness warriors, Dr. Perlus offers a compelling framework for managing fear, reframing perfection, and cultivating momentum—even in the face of chronic illness and burnout. Together, they dive into the emotional quadrants of resilience, the role of low-positive emotional states (like calm and reflection), and the importance of pre-performance rituals in healing journeys.. Whether you’re navigating stress, autoimmune challenges, or simply seeking to live with more presence and purpose, this conversation will help you tap into the energy of intention and rediscover your own power to heal. 🔹 About Dr. Haley PerlusWith a Ph.D. in sport and exercise psychology, Dr. Perlus is an international keynote speaker, author of The Personal Podium, and trusted coach to elite performers worldwide. She helps individuals conquer mental blocks, unlock motivation, and perform with purpose. Learn more at drhaleyperlus.com. TIMESTAMPS 00:00 – Welcome & Sponsor01:04 – Fear as an Ally in Healing02:09 – Lessons from Elite Athletes07:12 – The Power of Intention10:18 – Daily Recovery and Acceptance15:52 – Working with Fear, Not Against It21:57 – Resilience vs. Perfection30:18 – Emotional Quadrants of Resilience36:22 – Stillness vs. Active Recovery41:54 – Healing Imagery & Visualization44:26 – Dr. Perlus’s Work & Offerings47:52 – Final Words: Right Foot, Left Foot Attention listeners: Since 2019, we have been providing free content that is life-changing and valuable. The expense of producing a high-level podcast depends on your generosity; please support us through our affiliate sponsors. You can support the podcast through affiliate sponsors like ⁠⁠⁠⁠Healthgevity⁠⁠⁠⁠ (use code ONETHING for 10% off)

What happens when all your supplements, clean eating, and protocols stop working—and you just keep getting sicker? Danielle Pashko had built her career in functional medicine, doing everything “right.” But after thyroid cancer, Lyme disease, and long COVID wrecked her health, she hit a wall. Nothing worked—until she stopped chasing fixes and started going inward. In this episode, Danielle shares how she finally started healing by rewiring her nervous system, using Qigong, martial arts, and visualization. She breaks down why most chronic illness approaches miss the mark, why emotions and stress regulation matter more than you think, and how she created a daily routine that actually stuck. If you’re stuck in a healing rut, frustrated with endless protocols, or just want to feel like yourself again—this one’s for you. Timestamps:00:00:00 – Intro + Sponsor00:01:05 – Meet Danielle & her health crash00:03:22 – From teenage loss to holistic health00:05:14 – Cancer at 30 despite doing it all right00:06:57 – Why functional medicine didn’t cut it00:08:42 – The role of nervous system dysregulation00:10:47 – Visualization + martial arts: weird but it worked00:13:15 – Lessons from her mother’s spiritual approach00:17:45 – Pleading with the universe—and finding help00:22:32 – When the body shifts before the mind00:26:15 – Wing Chun, Qigong, and brain rewiring00:29:34 – The daily stuff that actually made a difference00:33:42 – Carnivore diet, CGMs, and getting real about food00:38:16 – How nature helped heal when nothing else did00:42:50 – Making healing sustainable (not another to-do list)00:46:41 – What “Soul Hacker” really means00:49:28 – The soul work behind real healing00:50:09 – Connect with Danielle Attention listeners: Since 2019, we have been providing free content that is life-changing and valuable. The expense of producing a high-level podcast depends on your generosity; please support us through our affiliate sponsors. You can support the podcast through affiliate sponsors like ⁠⁠⁠Healthgevity⁠⁠⁠ (use code ONETHING for 10% off)

In this episode of The One Thing Podcast, Dr. Sarah Nasir shares her visionary approach to treating addiction through a deeply integrative and compassionate lens. As an osteopathic physician and founder of Zara Care, she is reshaping addiction recovery by combining primary care with holistic healing, addressing the mind, body, and spirit. Dr. Nasir opens up about her personal transformation from stigmatizing addiction to becoming a leading voice for destigmatization in medicine. She explains how visual storytelling and simplified communication are critical tools for building trust with patients. We explore medication-assisted treatment (MAT), the science behind opioid addiction, and why healing isn't just about abstinence but creating a life of purpose. You'll hear how she uses metaphors, guided imagery, and Eastern philosophy to help patients reconnect with their inner strength, and why she believes everyone is “greatness in progress.” If you’re a clinician, caregiver, or simply someone interested in what it means to treat addiction with empathy and science, this episode is a must-watch. 🔗 Learn more: https://zenaracare.com 00:00 Introduction and sponsor message01:06 Meet Dr. Sarah Nasir and Zara Care03:44 Why addiction medicine? A personal evolution09:01 Meaning behind the name “Zara”12:33 Six dimensions of holistic healing14:41 What integrative addiction care looks like18:00 Core principles: trust, communication, and balance20:05 MAT explained with visual metaphors25:10 Recovery phases: induction, maintenance, taper30:33 Storytelling tools in patient care31:51 Fixing systemic gaps in addiction treatment35:40 Dr. Nasir’s long-term vision for Zara38:35 Final thoughts and call to action Attention listeners: Since 2019, we have been providing free content that is life-changing and valuable. The expense of producing a high-level podcast depends on your generosity; please support us through our affiliate sponsors. You can support the podcast through affiliate sponsors like ⁠⁠Healthgevity⁠⁠ (use code ONETHING for 10% off)

In this episode, Dr. Adam Rinde welcomes back microbiologist and PolyBio Research Foundation co-founder Dr. Amy Proal. Together, they unravel a framework for understanding chronic illnesses through the lens of persistent infections and their impact on mitochondria, immunity, and neurological health. Dr. Proal shares cutting-edge research linking pathogens like herpesviruses, cytomegalovirus, Epstein-Barr, and even latent parasites to conditions like Alzheimer’s, long COVID, chronic fatigue syndrome, POTS, and more. Discover how stealth microbes can disrupt the vagus nerve, hijack mitochondrial energy systems, and weaken immune responses, setting the stage for a cascade of chronic dysfunctions. The conversation dives deep into the role of immune modulation, including promising findings around low-dose rapamycin and its potential to restore immune signaling and combat viral persistence. They also explore diet, metabolic interventions, and new clinical trials shaping the future of treatment. Whether you’re a patient, practitioner, or curious mind, this episode offers profound insight into the evolving science of chronic illness and hope for emerging therapies. 🌱 🕰 TIMESTAMPS 00:00 – Intro + Sponsor Healthgevity⁠⁠ (use code ONETHING for 10% off)01:04 – Meet Dr. Amy Proal03:14 – Chronic infection’s hidden role in disease07:09 – Alzheimer’s and pathogens in the brain13:16 – Viral persistence and the vagus nerve15:37 – Spectrum of microbes linked to illness18:51 – PolyBio’s research focus: long COVID & mitochondria20:11 – How viruses hijack mitochondria25:46 – Immune dysregulation, interferons & mTOR27:41 – The promise of low-dose rapamycin32:32 – Rapamycin vs. Metformin vs. Keto36:25 – Chronic infection & metabolic downshift39:31 – Early observations from rapamycin use43:13 – Natural killer cells & new immunotherapy46:15 – Final thoughts + how to support PolyBio 🎧 Follow the One Thing Podcast for more deep dives into root-cause medicine and emerging research.📢 Learn more at polybio.org and support their transformative work. You can support the podcast through affiliate sponsors like ⁠Healthgevity⁠ (use code ONETHING for 10% off)Full Show notes can be found at https://www.onethingpod.com/episode-117-the-hidden-microbial-drivers-of-chronic-illness-with-dr-amy-proal/