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"Got Knowledge Doc" Podkast with Dr. RR Baliga The "Got Knowledge Doc" Podkast, hosted by Dr. Ragavendra R. Baliga, is a knowledge-driven platform designed for physicians and healthcare providers seeking to stay at the forefront of medical science and innovation. With a distinguished career in cardiovascular medicine and academic leadership, Dr. Baliga engages with leading experts to explore cutting-edge research, emerging technologies, and transformative insights in medicine and beyond. Each episode delves into topics such as cardiology, precision medicine, artificial intelligence in healthcare, epigenetics, and medical ethics—making complex advancements accessible and relevant to clinical practice. Importantly, this podcast is purely educational and does not provide medical advice or clinical opinions. Join Dr. Baliga and his esteemed guests as they navigate the evolving landscape of medical knowledge, empowering healthcare professionals with evidence-based insights that shape the future of patient care.

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Check latest episodes from Dr RR Baliga's "Got Knowledge Doc" Podkast podcast

Residual Risk in CAD: What Remains, Why It Matters, What to Do 🫀⚠️💡

2026/02/04

🫀 Residual Risk in Coronary Artery Disease Even after "optimal" therapy, many patients remain at risk. Why? Because atherosclerosis is more than LDL—it's thrombosis 🩸, inflammation 🔥, and metabolism ⚖️ working in concert. This FAQ-based slide deck distills contemporary insights on residual thrombotic, lipid, metabolic, and inflammatory risk, and highlights emerging therapies—from dual-pathway inhibition 💊 to GLP-1 receptor agonists 🧬 and colchicine—that help close the gap between treatment and outcomes. 📊 Key message: precision, not complacency. #Cardiology #SecondaryPrevention #ResidualRisk #CAD #PrecisionMedicine

Dr RR Baliga's Philosophical Discourses: Swami Vivekananda--–Vedanta and Yoga

2026/02/03

Swami Vivekananda reminded the world that spiritual strength and social service are inseparable 🕉️🔥 From Chicago in 1893 to India's national awakening, his message was simple yet radical: each soul is potentially divine—and serving humanity is serving the Divine 🌍🤝 More than a monk or philosopher, Vivekananda remains a timeless call to courage, compassion, and inner awakening ✨📚

🫀 Sense. 🧠 Signal. 🛡️ Scar. A Heart–Brain–Immune Loop in Myocardial Infarction

2026/02/02

🫀🧠🛡️ Sense. Signal. Scar. A striking Cell study reframes myocardial infarction as a systems disease, not a heart-only event. Using single-cell and spatial transcriptomics in murine MI, the authors identify a triple-node heart–brain–immune loop: TRPV1-positive vagal sensory neurons (injury sensing) → hypothalamic paraventricular nucleus AT1aR neurons (central integration) → superior cervical ganglion IL-1β signaling (sympathetic–immune effector arm). Intervening at any node improved ejection fraction, reduced infarct size, and normalized autonomic balance—pointing to neuroimmune modulation as a new therapeutic frontier beyond myocardium-centric care. 📌 Key takeaway: Treat the circuit, not just the scar. 📖 Yadav et al., Cell (2026)

👉 Urge. Move. Repeat: The Modern Story of Restless Legs Syndrome 🔄🛌

2026/02/01

🦵🌙 Restless Legs Syndrome: more than a sleep complaint RLS affects ~3% of adults and is frequently missed or misdiagnosed as insomnia or anxiety. The latest evidence underscores three practical shifts: think iron (even when "normal"), choose gabapentinoids first, and beware dopaminergic augmentation. For internists and frontline clinicians, recognizing RLS early can meaningfully improve sleep, mood, and quality of life—and may even reduce downstream cardiovascular risk. 🧠🩺💤 #RestlessLegsSyndrome #SleepMedicine #InternalMedicine #IronDeficiency #Gabapentinoids #Augmentation #PLMS #ClinicalPractice

⚙️ The Operating System of Cancer: Hallmarks, Enablers, Ecosystems

2026/01/31

🧠🩺 Why cancers behave the way they do—and why treatments fail For internists, cancer is not just an oncologic diagnosis but a systems disease: driven by dysregulated growth, immune evasion, metabolic reprogramming, inflammation, and adaptive resistance. The Hallmarks of Cancer framework offers a unifying clinical lens—explaining recurrence, cachexia, immunotherapy variability, and late relapse—without drowning us in molecular minutiae. Understanding how tumors survive stress, therapy, and time sharpens prognosis, improves cross-disciplinary care, and strengthens bedside reasoning. 🔬 From biology to bedside. 🧩 From mechanisms to meaning. 📈 From treatment to trajectory.

🕔🏃‍♂️ Five Minutes More, Fewer Funerals

2026/01/30

📟🪑🏃‍♂️ A striking accelerometer-based analysis in The Lancet suggests that small, realistic behavior shifts could translate into meaningful mortality gains at the population level. For the least active adults, +5 minutes/day of moderate-to-vigorous physical activity (MVPA) was associated with preventing ~6% of deaths; applying a similar increase broadly (excluding the most active) could prevent ~10%. Reducing sedentary time by 30 minutes/day was associated with preventing ~3% (high-risk) to ~7% (population) of deaths (with smaller—but still meaningful—effects in UK Biobank). 🎯 Practical takeaway: "5 minutes more exercise, 30 minutes less sitting." Small hinges, big doors. (Ekelund et al., The Lancet, 2026)

A Disease of Legs, A Warning for Life 🦵⚠️❤️ Peripheral Artery Disease and Long-Term Cardiovascular Mortality

2026/01/29

🦵❤️ Peripheral Artery Disease is not just a leg problem—it's a life-threatening cardiovascular signal. Up to 60% of patients are asymptomatic, yet PAD doubles to triples the risk of myocardial infarction, stroke, and death. Evidence is clear: exercise therapy, statins, antiplatelet or rivaroxaban-based strategies, blood-pressure control, and GLP-1/SGLT2 therapies save limbs and lives. 🚶‍♂️💊🫀 When walking hurts—or quietly fades—cardiovascular risk rises. PAD deserves the same urgency as coronary disease. #PeripheralArteryDisease #PreventiveCardiology #Claudication #ExerciseMedicine #Atherosclerosis #CardioVascularRisk

Numbers That Matter 🔢🫀🌍: The AHA 2026 Cardiovascular Report

2026/01/28

🫀 What do the 2026 AHA Statistics really tell us? The latest AHA update makes one message unmistakably clear: prevention works—but only when systems work. From Life's Essential 8 🧭 to the rise of cardiovascular–kidney–metabolic (CKM) health 🩺🧪, the data show that blood pressure control, sleep 😴, physical activity 🚶‍♂️, nutrition 🥗, and nicotine cessation 🚭 shape not only heart outcomes, but brain health 🧠, equity ⚖️, and healthcare costs 💰. The challenge ahead isn't discovering new risk factors—it's implementing what we already know, at scale and with fairness. Prevention is no longer aspirational; it's clinical, economic, and moral necessity.

Dr RR Baliga's Philosophical Discourses: Sri Ramakrishna Paramahamsa (India, 1836–1886 CE) – Mysticism

2026/01/27

Sri Ramakrishna Paramahamsa showed that spiritual truth is lived, not debated 🌼🙏 Through devotion, deep experience, and simple parables, he taught that all religions are different paths to the same Reality 🛤️✨ His enduring message—serve humanity as the Divine—continues to inspire seekers, caregivers, and leaders alike ❤️🌍

Cardiac Pace with a Purpose: Protect EF 🛡️🔌📉

2026/01/26

CRT—now framed as cardiac physiologic pacing—remains a cornerstone for HFrEF patients with LVEF ≤50% and either high ventricular pacing burden or a wide QRS, with the biggest gains in LBBB and QRS ≥150 ms. ⚡🫀📈 Traditional biventricular pacing has randomized-trial evidence (>10,000 patients) showing better symptoms, quality of life, remodeling, fewer HF hospitalizations, and survival benefit in selected groups; meanwhile His bundle and left bundle branch pacing are rapidly expanding options, with large randomized trials underway to define comparative efficacy and safety. 🧠🔧🔬

🌍🏠❤️ From Clinic to Community: Closing the BP Control Gap

2026/01/25

🩺 Hypertension control in the U.S. has stalled—despite better meds, better evidence, and better tools. 📉 The "paradox" isn't a mystery so much as a systems problem: therapeutic inertia, fragmented care, cost barriers, and inconsistent use of validated home BP monitoring. 🧩 What works is boring (and therefore powerful): standardized treatment protocols, team-based care, rapid follow-up, combination therapy when appropriate, and performance feedback loops. 🧰📊 If we treat BP control like a reliable system—rather than a heroic, one-visit effort—we can move the curve again. 🎯❤️ #Hypertension #PrimaryCare #Cardiology #QualityImprovement #PopulationHealth

🧬🛡️🕰️ Why Cancer Usually Waits for Old Age

2026/01/24

🧬 Why does cancer mostly strike later in life? This review frames an elegant answer: evolution built layered anti-cancer "barriers" optimized to protect us through reproductive years—not indefinitely. 🛡️ With aging, those safeguards fray: tissues remodel, epigenetic "noise" rises, inflammation smolders, and immune surveillance softens—so clones that were once contained can progress. 🕰️🔥 A favorite reminder is 🐘 Peto's paradox: bigger, longer-lived species aren't overwhelmed by cancer, suggesting nature can evolve stronger defenses when fitness demands it. Takeaway: late-life cancer risk isn't just "more mutations"—it's changing context + weakening constraints. ✅

Diverse Exercise, Lower Death Risk 🎯🏃‍♂️⬇️⚰️

2026/01/23

🏃‍♀️🏋️‍♂️ Does variety in physical activity matter for longevity? A large prospective analysis suggests it does: people who engaged in a wider mix of activity types tended to have lower all-cause mortality, even after accounting for total activity and key covariates. 🌈📉 Key practical takeaway: don't just "do more"—do different (walk + cycle + swim + strength, etc.). ✅🫀 As always, this is observational data (residual confounding + self-report remain). Still, it's a compelling nudge toward diversity in movement as a realistic, patient-friendly goal. 💡👟 #PhysicalActivity #Prevention #Cardiology #PublicHealth #LifestyleMedicine

🧠➡️❤️ Rewiring the Heart: When the Vagus Nerve Saves Cardiac Function

2026/01/22

🧠❤️ Rewiring the Heart—Literally A striking Science Translational Medicine study shows that early reconnection of the right vagus nerve to the heart preserves ventricular mechanics, synchrony, and myocardial health—even when only ~20% of vagal fibers regenerate. 🧵🫀 Using a clinically relevant minipig model, the authors demonstrate that loss of parasympathetic input drives oxidative stress, inflammation, and premature cardiac aging—while targeted nerve repair reverses these pathways, independent of heart rate. 📉➡️📈 Implications: thoracic surgery, heart–lung transplantation, and the future of autonomic cardioprotection. Sometimes, saving the heart means listening to the nerve. 🎧💡 📖 Science Translational Medicine, Dushpanova et al., 2025

Dr RR Baliga's Philosophical Discourses: Friedrich Nietzsche (Germany, 1844–1900 CE) – Nihilism

2026/01/20

Friedrich Nietzsche challenged the modern mind to think bravely, live honestly, and create meaning rather than inherit it 🧠⚡ From "God is dead" to self-overcoming, his ideas push us to confront nihilism and affirm life with courage and creativity 🔥🎭 More than a philosopher, Nietzsche remains a provocation—asking each of us: what values will you create? 🚀📚

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6 reviews

★★★★★

mochachip05 2021/01/14

Great for board prep

This is an incredible resource for board review and general IM knowledge podcast. I wish all IM interns listened to this. I regularly listen to this o...

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