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Once a Scientist

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Rating
★★★★★
4.9
from
54 reviews
Categories
Country
United States
This podcast has
103 episodes
Language
English
Publisher
Nick Edwards
Explicit
No
Date created
2020/04/01
Latest episode
2026/09/15
Average duration
58 min.
Release period
63 days

Description

Unfiltered career discussions with scientists

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Podcast episodes

Check latest episodes from Once a Scientist podcast


98. Renee Wegrzyn and Anna Marie Wagner, Founders of Transfyr, on Why Science's Reproducibility Problem Isn't in the Lab Notebook
2026/09/15
Renee Wegrzyn, PhD, is co-founder of Transfyr AI. Recognized as a TIME 100 Innovator, Rock Health Top 50 Digital Health Innovator, and recipient of the Superior Public Service Medal, Renee holds a BS and PhD in Applied Biology and Bioengineering from Georgia Tech. She spent over a decade at DARPA, including as a program manager focused on gene editing and biomanufacturing and as a technical advisor to IARPA, where she ran "moonshot" programs. She later became VP of Business Development & Head of Innovation (Biosecurity) at Ginkgo Bioworks. Anna Marie Wagner is co-founder of Transfyr AI. She holds a B.A. in Applied Mathematics from Harvard University and an MBA from Harvard Business School. She spent nearly a decade at Bain Capital Private Equity, eventually focusing on vertical software, before joining the executive team at Ginkgo Bioworks. She built out Ginkgo's AI team and oversaw major strategic transactions, including the 2021 IPO (raised $1.6B — reportedly the largest-ever go-public raise in biotech). Learn more about Transfyr in the recent NYTimes feature: https://www.nytimes.com/2026/08/27/science/scientists-experiments-replication-ai.html
97. Ron Alfa, CEO of NOETIK, on Biology as a Search Problem
2026/08/18
Ron is Co-Founder and CEO of NOETIK, a next generation precision oncology company using multimodal foundation models pre-trained on large-scale human tumor data to discover cancer therapeutics. He holds an MD and PhD from Stanford University School of Medicine, where he completed his doctoral work in Neuroscience, and has a MA in History of Medicine from UCL. Prior to founding Noetik, Ron was Senior Vice President, Head of Research and acting-CSO at Recursion, where he led the company’s scientific organizations and portfolio strategy. At Recursion, he led portfolio and platform builds across rare disease, neuroscience, oncology, and immunology, and was responsible for advancing multiple therapeutic programs from discovery to clinical development.
96. Chris Anderson, Advisor to Pillar VC and former Wired Editor, on How Adjacent Technologies Will Transform Lab Automation
2026/07/29
Chris Anderson currently serves as an advisor at Pillar VC and Renaissance Philanthropy. He was editor of WIRED and spent seven years at The Economist, where he worked as editor of both the technology and business sections. Anderson holds a degree in physics from UC Berkeley, has conducted research at the Los Alamos National Laboratory, and has done stints at the leading journals Nature and Science.
95. Stacie Calad-Thomson, Head of BioPharma Labs and Manufacturing BD at NVIDIA, on AI as an endless collaborator
2026/06/10
Stacie Calad-Thomason is Head of BioPharma Labs and Manufacturing Business Development at NVIDIA. She has a PhD in Chemistry from UC Irvine and a B.A. in Chemistry from UC Berkeley. Topics & Timecodes: Physical AI Tools (Omniverse, Cosmos, Isaac, Groot) [04:46] Lab Automation Bottlenecks [06:20] Simulation vs Physical AI in Biology [09:42] Stacy's PhD Journey & Serendipitous Discovery [13:21] Transition from Academia to GSK Industrial R&D [19:15] Early AI Adoption in Drug Discovery (ADAM Consortium) [23:57] Efficiency as Career Motivation [27:14] Leadership at Atomwise During COVID [29:02] Biosymetrics & Phenomics Work [33:31] Vision for AI Scientists [35:11] AI Impact on Research Workflows [38:09] Career Advice: Perseverance, Adaptability & Skill Breadth [41:10]
94. Ira Hoffman, CEO of HighRes on robots, digital twins and how we will speed up science
2026/05/06
Ira Hoffman is the CEO of HighRes. He has a M.S. in Computer Science and a B.A. in Physics/Mathematics from the University of Vermont.  OUTLINE: [00:00] - Introduction to collaborative robots and safe human-robot coexistence [01:52] - CEO of Hi Res (formerly Hi Res BioSolutions), 20-year journey in lab automation [03:36] - Deep diving into AI strategy and product development [05:23] - From large-scale automation to accessibility for scientists [06:45] - How robots safely coexist with humans in labs [09:19] - Too many unvalidated hypotheses from AI tools [09:39] - Moving from high-throughput screening to prescriptive hypothesis testing [11:21] - Physical and digital integration challenges [15:46] - How chaos in early research differs from standardized processes [19:17] - Why fully autonomous labs are still far away [21:09] - Identifying automation opportunities vs. necessary human involvement [22:13] - Why large molecule biologics are easier to automate [23:36] - A leading example of closed-loop design-make-test-analyze [27:22] - AI-powered products enhancing automation workflows [28:47] - How to upskill teams in using AI tools effectively [31:44] - 3D visualization, AR overlays, and workflow simulation [36:36] - Why capturing contextual data is critical for consistent results [39:43] - Leadership approach under pressure and creativity [41:57] - Find your passion in science and technology  -
93. Jason Kelly, CEO and co-founder of Ginkgo Bioworks, on the future of autonomous laboratories
2026/02/25
Episode 93. Jason Kelly is the co-founder and CEO of Ginkgo Bioworks. He has a Ph.D. in Biological Engineering and a B.S. in Chemical Engineering and Biology from the Massachusetts Institute of Technology. References: https://www.ginkgo.bio/autonomous-lab OUTLINE: 00:00 – From Jurassic Park Pilled to MIT 03:00 – Founding Ginkgo During the 2008 Crash 07:00 – Tom Knight & Thinking About Biology Like Software 11:00 – Why Biology Lacked Abstraction (Until Now) 16:00 – The Foundry Model: Centralizing Biology 20:00 – The 5 Levels of Lab Automation 23:00 – Automation vs. Autonomy (Subway vs. Waymo) 27:00 – The Technical Bottleneck: Connecting 150+ Machines 34:30 – The Zymergen Acquisition & Strategic Pivot 38:00 – Level 4 & 5 Labs: The Future of Programmable Biology
92. Ashlee Vance, tech reporter and filmmaker, on storytelling, science funding, and interviewing billionaires
2025/07/23
Episode 92. Ashlee Vance is a renowned tech and science reporter, filmmaker, and founder of Core Memory, a podcast and blog that chronicles the lives and discoveries of scientists and engineers (https://www.corememory.com/). He wrote the definitive biography on Elon Musk and has been documenting the modern space race and recent developments in AI, among other things.
91. Michael Koeris, Director of DARPA BTO, on autonomous science to accelerate discovery
2025/04/23
Episode 91. Michael Koeris is the Director of the Biotechnologies Office at DARPA. Michael completed his PhD at Boston University and did postdoctoral research in synthetic biology at MIT. He spent time early in his career at Flagship Pioneering, is a former founder and executive of multiple biotechs,  and was formerly a professor at the Keck Graduate Institute.
90. Barry Bunin, CEO at Collaborative Drug Discovery, on tapping into the collective consciousness of science.
2024/12/18
Episode 90. Barry Bunin is the CEO and President at Collaborative Drug Discovery, which he founded 20 years ago. Prior to that, Barry was an Entrepreneur in Residence at Eli Lilly. He completed his PhD in Bioorganic Chemistry at UC Berkeley and his bachelor's degree in chemistry at Columbia University. To learn more about CDD:  https://www.collaborativedrug.com/ai-drug-discovery#Bioisosteric-Suggestions https://www.collaborativedrug.com/curves#Calculations https://www.collaborativedrug.com/automation
89. Seemay Chou, CEO of Arcadia Science, on metascience and rethinking the structure of science
2024/10/30
Seemay Chou is co-founder and CEO at Arcadia Science, Board Member at Astera Institute, and Board Chairperson at The Navigation Fund. Seemay was previously an assistant professor at UCSF and completed her PhD in Molecular and Cell Biology at UC Berkeley.
88. Gene Yeo, professor at UC San Diego, on team science and building a training playground
2024/10/01
Episode 88. Eugene Yeo is a Professor at UC San Diego and is building a scientific ecosystem in San Diego. He runs the Innovation Center at Sanford Stem Cell Institute, is Scientific Director at the Sanford Consortium, Chief Scientist at the Sanford labs for Innovative Medicines, and Director of UC San Diego’s Center for RNA Technologies and Therapeutics.
87. Jesse Gray and Sud Pinglay, at SeaHub, on recording cellular activity and making big bets
2024/08/30
Episode 87.  Sudarshan Pinglay is a researcher at the University of Washington and faculty at the Seattle Hub for Synthetic Biology (SeaHub). He did his PhD at New York University and bachelor's degree at Johns Hopkins. Jesse Gray is a Senior Director at SeaHub. He previously worked in industry at Ascidian Therapeutics and as a professor at Harvard Medical School. Jesse completed his PhD at UCSF and his undergrad at University of Wisconsin.
86. Prachee Avasthi, CSO at Arcadia Science, on exercising agency and doing science differently
2024/07/17
Episode 86. Prachee Avasthi is co-founder and Chief Scientific Officer at Arcadia Science and Head of Open Science at the Astera Institute. Prachee was previously a professor at Dartmouth and University of Kansas. She completed a PhD in Neuroscience at University of Utah and her bachelor's degree at the University of Illinois Urbana-Champaign.
85. Fay Lin, science journalist and editor, on seeking out diverse voices and learning from experts
2024/05/29
Episode 85. Fay Lin is a Senior Editor at GEN Biotechnology. She completed her PhD in Biochemistry, Molecular, and Structural Biology at UCLA and undergrad in Biology at NYU with minors in Computer Science and Chemistry. GEN Biotechnology website:  https://home.liebertpub.com/genbio Call for Papers: Special Issue in AI in Biotechnology:  https://home.liebertpub.com/cfp/special-issue-artificial-intelligence-in-biotechnology/497/
84. Maryann Martone, professor at UC San Diego, on neuroinformatics, reproducibility, and open science
2024/04/24
Episode 84. Maryann Martone is an emeritus professor of neuroscience at UC San Diego. She received her BA from Wellesley College in Biological Psychology and Ancient Greek and her PhD in Neuroscience from the UC San Diego

Podcast reviews

Read Once a Scientist podcast reviews


4.9 out of 5
54 reviews
★★★★★
rs22biker 2025/05/23
“Real Talk for Scientists, Innovators, and the Wonderfully Curious”
Nick Edwards brings something rare to the mic: a combination of humility, curiosity, and genuine human warmth that makes Once a Scientist more than ju...
★★★★☆
Se9712 2024/09/03
Bad quality of voice but good content
The conversation and topics are great but the quality of voices are really bad, especially the guests, quite annoying to listen to.
★★★★★
Ddoddoodthe2 2020/08/22
Great podcast
Great content. I love the honesty and how people can share openly.
★★★★★
marizard 2020/08/13
Give it a try!
Fantastic pod. Nick does a great job of asking pointed, insightful questions while still keeping the conversation lighthearted and entertaining. The l...
★★★★★
Aa391 2020/07/22
Great interviews!
This is a great podcast for graduate students or anyone who aspires to work in science. I love the honesty in the interviews.
★★★★★
Spcycabbge84 2020/04/08
Raw and funny
Super easy to listen to, fun and engaging!
★★★★★
Cody Jam 2020/04/07
Smart & Funny
Really really smart, really funny, real-life side of science is super interesting and fun!
★★★★★
LesMoreGG 2020/04/06
Praying for this show
To discover the Rona-virus’s cure
★★★★★
wbmore 2020/04/06
Just what I needed during this pandemic
Each episode feels like a happy hour with cool, creative people who've had exciting professional trajectories. Fun and insightful. Highly recommend!
★★★★★
Tyler Culbertson 2020/04/05
congrats in the new show!
I am super excited to share this new podcast withmy friends! I am honored to play a small part in this show as, co-producer
check all reviews on apple podcasts

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