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AI is no longer just writing emails, summarizing documents, or answering questions. The rise of agentic AI is transforming how organizations make decisions, automate workflows, manage risk, and deliver services - especially in highly regulated industries such as healthcare, biotechnology, pharmaceuticals, and hospital systems. In this episode of Rx for Biotech, host Chris Leidli meets with Bennet Borden, lawyer, data scientist, and founder of Clarion AI, an AI-native legal and technology consultancy, to explore why this next wave of artificial intelligence could fundamentally reshape the future of professional services and healthcare. Bennet brings an unusual perspective to the AI revolution. His career spans intelligence analytics, leading global law firms, AI governance, enterprise technology, and the development of AI-powered systems. As AI moves from generating content to taking action, healthcare organizations face a new challenge: How do you safely deploy AI systems that make recommendations, perform tasks, and influence decisions affecting real people? Bennet explains why successful AI transformation requires that organizations rethink workflows, how to unlock proprietary data, develop specialized AI agents, and build governance directly into their systems. And perhaps most importantly, they must understand that AI transformation is as much about people as technology. In this episode, we discuss: • Generative AI vs. agentic AI: Why moving from generating content to performing tasks changes everything. • AI and the future of law: The analysis of 14,000 attorneys and why traditional professional services are facing disruption. • Agentic AI in healthcare: Opportunities for medical documentation, clinical decision support, diagnostic workflows, and patient services. • AI governance and compliance: How pharmaceutical companies and hospital systems can manage AI risk, safety, accountability, and regulatory uncertainty. • The AI black-box problem: Why measuring what AI systems actually do matters more than debating how they work internally. • Build vs. buy: Why general-purpose AI tools may deliver productivity improvements but not lasting competitive differentiation. • Enterprise data and AI agents: How organizations can leverage internal knowledge and expertise through specialized agentic workflows. • AI transformation and change management: Why Bennet describes transformation as 20% technology and 80% psychology. • Human expertise and AI augmentation: Why the goal should be Iron Man, not the Terminator. • AI vendor contracts: What healthcare and life sciences organizations should consider when evaluating accountability, indemnification, and risk allocation. • The future of AI in healthcare: Why the human relationship between patients and clinicians remains essential. Whether you are a biotechnology executive, pharmaceutical leader, clinician, hospital administrator, attorney, AI developer, or investor, this conversation offers a practical perspective on adopting artificial intelligence responsibly while remaining competitive. Connect with Bennet Borden at Clarion AI Partners Website: https://clarionailaw.com About "Rx for Biotech" Podcast Rx for Biotech explores how biotechnology, artificial intelligence, precision medicine, and advanced therapies are transforming healthcare. Hosted by Chris Leidli, Founder and CEO of Genoplex, the podcast features conversations with executives, physicians, scientists, and innovators building the future of medicine. Subscribe to Rx for Biotech for more conversations on agentic AI, biotechnology innovation, healthcare technology, personalized medicine, and patient access. This episode is intended for educational and informational purposes and does not constitute legal, regulatory, or medical advice.

What if your fatigue, anxiety, weight gain, poor sleep, low libido, or brain fog are not “just stress”? Too many women are told they are stressed, anxious, depressed, or “just getting older” when their symptoms may deserve a deeper look. In this episode of Rx for Biotech, host Chris Leidli sits down with Sharon Lemoine, ARNP, Owner of Gig Harbor Medical Center, to discuss women’s health, hormone therapy, menopause, functional medicine, concierge care, peptides, GLP-1s, and the growing demand for a more personalized model of healthcare. Sharon brings a rare perspective to this conversation. She spent 25 years in emergency medicine before building a faith-based functional medicine and concierge care practice in Gig Harbor, Washington. Her clinical journey was also shaped by her own health experiences, including Type 1 diabetes, surgical menopause, Graves’ disease, and thyroid cancer. That combination of provider experience and patient experience now informs how she cares for midlife women and men who feel unheard, rushed, or dismissed by conventional healthcare. A major theme of this episode is that many patients - especially women navigating perimenopause and menopause - are told their symptoms are simply stress, aging, anxiety, or depression. Sharon explains why symptoms such as fatigue, irritability, mood changes, weight gain, poor sleep, low libido, and loss of muscle may deserve a deeper evaluation, including hormones, thyroid function, metabolic health, nutrition, and lifestyle. This conversation is especially relevant for women in their 30s, 40s, 50s, and beyond who are navigating unexplained symptoms, hormone changes, menopause, weight gain, fatigue, anxiety, low libido, poor sleep, or frustration with rushed medical visits. It is also relevant for men interested in testosterone, metabolic health, energy, longevity, and performance as they age. Sharon’s central message is clear: patients should not discount their symptoms. If you feel unheard, rushed, or dismissed, it may be time to find a provider who will take the time to understand the full picture. Subscribe to "Rx for Biotech" channel for conversations with clinicians, founders, scientists, and healthcare leaders shaping the future of personalized medicine, advanced therapies, longevity, and patient-centered care. This episode is for educational purposes only and should not be interpreted as medical advice. Always speak with a qualified healthcare professional before starting, stopping, or changing any medical treatment. #WomensHealth #HormoneHealth #Menopause #Perimenopause #Testosterone #FunctionalMedicine #ConciergeMedicine #GLP1 #Peptides #Longevity #ThyroidHealth #MetabolicHealth #PatientAdvocacy #RxForBiotech

We all know that cancer is caused by the rapid growth of tumor cells - but the ability for cancer to hide from the immune system is also a big challenge that scientists face when designing new therapies. In this episode of Rx for Biotech, host Chris Leidli speaks with John Friend, MD, CEO of Kazia Therapeutics, about a new approach to some of the most difficult-to-treat cancers, including glioblastoma, pediatric brain tumors, brain metastases, and triple-negative breast cancer. Dr. Friend uses a powerful metaphor throughout the conversation: many tumors develop something like an “invisibility cloak.” They adapt, resist treatment, avoid immune detection, and become harder for standard therapies to eliminate. Kazia Therapeutics is working to change that. The conversation centers on paxalisib, Kazia’s investigational brain-penetrant therapy designed to inhibit both PI3K and mTOR, two important cancer growth and survival pathways. John explains the PI3K pathway using a simple analogy: in cancer, this pathway can act like an accelerator stuck in the “on” position. By targeting PI3K and mTOR together, paxalisib is designed not only to take the foot off the accelerator, but also to apply the brakes. A major focus of the episode is glioblastoma, one of the most aggressive and difficult-to-treat brain cancers. John explains why glioblastoma has been so challenging for drug development, including tumor complexity, resistance, and the difficulty of getting drugs across the blood-brain barrier. Paxalisib was specifically designed to cross the blood-brain barrier—an essential feature for any therapy being developed for brain tumors. John also discusses Kazia’s expanding work in triple-negative breast cancer, where the company is studying paxalisib as an add-on to standard-of-care treatment with pembrolizumab plus chemotherapy. The goal is not simply to kill tumor cells directly, but to potentially reprogram resistant cancer cells, reduce circulating tumor cells, and make tumors more vulnerable to existing therapies and immune attack. In this episode, we discuss: • Why glioblastoma remains one of the hardest cancers to treat • What makes the blood-brain barrier such a major challenge in brain cancer drug development • How paxalisib was designed to cross the blood-brain barrier • Why the PI3K/mTOR pathway matters in cancer growth and resistance • The “accelerator and brake” analogy for PI3K and mTOR inhibition • Why Kazia is studying paxalisib in glioblastoma, pediatric brain tumors, brain metastases, and breast cancer • What makes triple-negative breast cancer so difficult to treat • How tumors can evade treatment through an “invisibility cloak” • Why combination therapy is increasingly important in oncology • How paxalisib may help reprogram resistant cancer cells • Early signals from Kazia’s triple-negative breast cancer work • Kazia’s emerging pipeline, including cancer-specific PD-L1 protein degradation • Why future cancer therapy may depend on making tumors visible again • Upcoming clinical and corporate milestones for Kazia Therapeutics This conversation is especially relevant for patients, caregivers, clinicians, researchers, biotech investors, and anyone interested in the future of brain cancer treatment, glioblastoma research, triple-negative breast cancer, targeted oncology, immunotherapy resistance, and precision medicine. Subscribe to Rx for Biotech for conversations with biotech CEOs, physicians, scientists, and industry leaders developing the next generation of personalized medicines and advanced cancer therapies. This episode is for educational purposes only and should not be interpreted as medical advice. Investigational therapies discussed in this conversation have not necessarily been established as safe or effective by regulatory authorities.

Can precision oncology help identify cancer’s genetic weaknesses and turn them into therapeutic opportunities? In this episode of "Rx for Biotech", host Chris Leidli speaks with Oren Gilad, CEO of Aprea Therapeutics, about the rapidly evolving field of synthetic lethality, DNA damage response, and targeted cancer therapies designed to exploit vulnerabilities in cancer cells. Oren shares how his scientific journey began at the University of Pennsylvania, where early experiments studying ATR helped shape the foundation for Aprea’s current cancer drug development strategy. That work led to a central insight behind synthetic lethality: cancer cells with specific genetic mutations may become highly dependent on certain DNA repair and checkpoint pathways for survival. Aprea is developing a pipeline of precision oncology therapies focused on what Oren describes as multiple targets in one critical pathway, including WEE1, ATR, p53 reactivation, and DYRK1 inhibition. A major focus of the conversation is APR-1051, Aprea’s investigational oral WEE1 inhibitor, which is being studied in patients with cancers carrying specific genetic alterations. Oren explains how WEE1 functions as a checkpoint in cell division, why cancer cells can become especially dependent on this pathway, and how inhibiting WEE1 may selectively target tumor cells while aiming to preserve a wider therapeutic window. This episode is especially relevant for anyone interested in precision medicine, targeted cancer therapy, DNA repair, synthetic lethality, oncology clinical trials, cancer biomarkers, and the future of drug development. Subscribe to Rx for Biotech podcast for conversations with biotech CEOs, scientists, physicians, and industry leaders developing the next generation of personalized medicines. This podcast is for educational purposes only and should not be interpreted as medical advice. Investigational therapies discussed in this episode have not necessarily been established as safe or effective by regulatory authorities.

Can we teach the immune system to attack solid tumors more effectively - and potentially create longer-lasting responses for cancer patients? In this episode of Rx for Biotech, host Chris Leidli sits down with Jack Silberstein, Founder and CEO of Deck Bio, to explore the next generation of cancer immunotherapy and why T-cell engagers could become an important new weapon against solid tumors. Jack's path into biotechnology started on the front lines of cancer care. As a clinical research coordinator at Johns Hopkins, he worked directly with patients with metastatic prostate cancer and saw firsthand the limitations of available treatments. That experience ultimately drove him to Stanford to study immunology and protein engineering - and eventually to build Deck Bio. At the center of the conversation is one of oncology's biggest challenges: Why have immunotherapies that can produce remarkable results in blood cancers been so difficult to translate into solid tumors? Jack explains T-cell engagers in patient-friendly terms: engineered molecules designed to bring a patient's own T cells into close contact with cancer cells, creating an artificial immune "synapse" that can trigger the immune system to attack the tumor. Deck Bio is taking that concept further with a multi-target T-cell engager platform designed to recognize four different cancer-associated targets with a single therapeutic molecule. The goal is to address one of cancer's defining characteristics - tumor heterogeneity - while maintaining specificity for cancer cells and reducing the risk of attacking healthy tissue. In this episode, we discuss: • What T-cell engagers are and how they work • Why solid tumors remain so difficult for cancer immunotherapy • How T-cell engagers differ from CAR-T cell therapy, chemotherapy, checkpoint inhibitors, and other cancer treatments • Deck Bio's multi-target approach to recognizing cancer cells • The company's lead program, DBX01, and its potential across multiple solid tumors • The emerging clinical validation of T-cell engagers in solid tumors • Why moving immunotherapy into earlier stages of cancer could matter • The potential for combination cancer therapies • How AI and AlphaFold are accelerating protein engineering and drug discovery • How AI could transform everything from molecule design to clinical trials and regulatory submissions One of the most important themes in this conversation is the possibility of moving beyond cancer treatments that work only while a patient remains on therapy. The long-term promise of immunotherapy is different: activate the immune system strongly enough that it continues recognizing and controlling cancer even after treatment stops. That remains one of the major ambitions of modern oncology and Jack believes next-generation T-cell engagers could help move the field closer to that goal. Whether you're a cancer patient or caregiver, oncologist, scientist, investor, or simply interested in the future of cancer treatment, this episode provides an accessible look at how advances in immunology, protein engineering, precision oncology, and artificial intelligence are converging to create entirely new approaches to treating solid tumors. Subscribe to Rx for Biotech for conversations with the leaders developing the next generation of cancer therapies, cell therapies, precision medicines, and advanced therapeutics. This episode is intended for educational purposes only. Investigational therapies discussed in this conversation have not necessarily been established as safe or effective and should not be interpreted as medical advice. #CancerImmunotherapy #CancerTreatment #TCellEngager #Immunotherapy #SolidTumors #PrecisionOncology #CancerResearch #Biotechnology #AIinHealthcare #DrugDiscovery #Oncology #RxForBiotech

Can artificial intelligence help cancer patients understand their diagnosis, find more personalized treatment options, and become better advocates for their own care? In this episode of Rx for Biotech, I met with Steve Brown, Founder and CEO of CureWise, an AI-powered patient advocacy platform designed to help people with cancer better understand their disease, prepare questions for their doctors, and explore precision oncology treatment options. For Steve, this mission is deeply personal. After months of unexplained health problems, Steve was ultimately diagnosed with amyloidosis, a rare plasma cell disorder closely related to multiple myeloma. He began using AI agents to analyze his medical records, laboratory results, biopsies, and emerging medical research. Rather than replacing his physicians, AI helped Steve identify patterns, understand the significance of his individual disease biology, and ask more informed questions of specialists. That experience ultimately helped inspire CureWise. In our conversation, Steve explains why he believes the next generation of AI in healthcare should go far beyond simply asking ChatGPT a medical question. CureWise brings together a patient's longitudinal medical information and uses multiple AI models to examine the case from different perspectives - helping patients better understand their cancer and participate more effectively in shared decision-making. The broader vision is not to replace oncologists, but to give patients a more powerful educational and advocacy tool. We also dig into one of the most important ideas in precision cancer care: cancer isn't defined only by where a tumor starts. Increasingly, genomic and molecular testing can reveal mutations and biomarkers that may influence targeted therapies, clinical trials, and other treatment strategies. In this episode: • Steve's personal journey from unexplained symptoms to a rare cancer diagnosis • How he used AI to analyze his medical records • Why AI should support—not replace—oncologists • How CureWise uses multiple AI models to evaluate complex medical information • Why genomic sequencing and biomarker testing matter in precision oncology • Standard-of-care cancer treatment vs. personalized treatment strategies • How patients can prepare more effectively for oncology appointments • AI and clinical trial matching • Why rare molecular subtypes challenge traditional clinical trial models • How AI could democratize access to expertise associated with major cancer centers • The importance of patient advocacy and shared decision-making • Steve's vision for using patient data and AI to accelerate future cancer research Steve's philosophy is particularly relevant for patients and caregivers: AI doesn't have to make the medical decision to be valuable. It can help patients understand the landscape, identify important questions, and participate more effectively in decisions with their oncology team. CureWise was built around that idea- that helping patients understand their specific cancer, identify questions to discuss with their oncology team, and explore clinical trials and emerging therapies that may be relevant to their care. If you or someone you love is navigating a cancer diagnosis, this conversation offers a provocative look at how artificial intelligence, genomic testing, precision medicine, and better patient education could change the cancer journey. Subscribe to Rx for Biotech for conversations with the scientists, physicians, entrepreneurs, and patients shaping the future of personalized medicine and advanced therapies. This episode is for educational purposes and does not provide medical advice. AI tools should not replace evaluation or treatment decisions by qualified healthcare professionals. #AIHealthcare #Cancer #CancerTreatment #PrecisionOncology #PrecisionMedicine #CancerResearch #GenomicTesting #PatientAdvocacy #ArtificialIntelligence #CancerCare #Biomarkers #ClinicalTrials #CureWise #RxForBiotech

Can stem cell therapy help repair damaged spinal discs instead of simply masking pain? Millions of people suffer from chronic low back pain and degenerative disc disease, yet today's standard treatments often focus on symptom management through pain medications, steroid injections, or invasive surgery. But what if regenerative medicine could change that? In this episode of Rx for Biotech, host Chris Leidli sits down with Lance Alstodt, CEO of BioRestorative Therapies, to explore how the company is developing next-generation regenerative medicine platforms designed to restore function—not just relieve symptoms. Lance discusses BioRestorative's lead clinical program, BRTX-100, an investigational autologous stem cell therapy currently in Phase 2 clinical development for chronic lumbar disc disease. The conversation explores how stem cells are expanded using the company's proprietary hypoxic manufacturing process before being injected directly into damaged spinal discs in an effort to promote tissue repair. The discussion also looks beyond spine health to BioRestorative's ThermoStem® platform, which is investigating the potential of brown adipose (brown fat) stem cells to improve metabolic health and complement GLP-1 weight-loss therapies. Finally, Lance explains how the company's expertise in stem cells and exosome biology is also being applied to next-generation skincare and regenerative aesthetics. In this episode you'll learn: • Why chronic low back pain remains one of healthcare's largest unmet needs • How regenerative medicine differs from traditional pain management • The science behind BRTX-100 and autologous stem cell therapy • Why BioRestorative uses proprietary hypoxic cell expansion • Current Phase 2 clinical trial progress and safety observations • The future of regenerative medicine for orthopedic diseases • How brown fat stem cells could complement GLP-1 therapies • What exosomes are—and why not all exosomes are created equal • The difference between FDA-regulated cell therapies and many commercial regenerative medicine clinics • BioRestorative's long-term vision for restoring function instead of simply managing symptoms Whether you're a patient living with chronic back pain, a healthcare professional, an investor, or simply interested in the future of regenerative medicine, this episode provides an inside look at one of the most exciting areas of biotechnology.

What if cancer treatment could find and destroy cancer cells with extraordinary precision while minimizing damage to healthy tissue? In Part 2 of this special Rx for Biotech series, Dr. Babak Saboury and Dr. Eliot Siegel from United Theranostics explain radioligand therapy (RLT), one of the fastest-growing areas in precision medicine and cancer treatment. Radioligand therapies combine advanced imaging and targeted radiation to identify, track, and treat cancer cells throughout the body. This emerging field, known as theranostics, allows physicians to "see what they treat and treat what they see." In this episode, you'll learn: • What radioligand therapy (RLT) is • How theranostics works • The difference between traditional radiation and targeted radiopharmaceutical therapy • How imaging helps personalize treatment • Why prostate cancer and neuroendocrine tumor patients are benefiting today • What patients can expect during treatment • Common side effects and safety considerations If you or someone you love has been diagnosed with cancer, this conversation is a good educational primer to one of the most promising advances in oncology. Subscribe for more patient-focused conversations on cancer treatment, precision medicine, immunotherapy, cell therapy, and healthcare innovation. #CancerTreatment #RadioligandTherapy #Theranostics #ProstateCancer #NeuroendocrineTumors #PrecisionMedicine

What does it really take to successfully launch a radiopharmaceutical? In Part 1 of this special roundtable “Rx for Biotech” podcast series, Chris Leidli met with Dr. Babak Saboury and Dr. Eliot Siegel, founders of United Theranostics and nationally recognized leaders in nuclear oncology, to discuss one of the biggest challenges facing the radiopharmaceutical industry today: building the infrastructure to expand patient access to these innovative medicines. While radioligand therapies (RLTs) and theranostics are generating unprecedented excitement in oncology, many pharmaceutical companies underestimate the complexity of delivering these therapies to patients. In this episode, we discuss: • Why only a small percentage of eligible patients currently receive radioligand therapy • Site readiness, staffing, and infrastructure challenges • Why traditional pharmaceutical launch models often fail in radiopharmaceuticals • Building sustainable access for patients • What pharmaceutical companies should understand before launching an RLT This conversation offers a front-line perspective on what it will take to scale the future of radiopharmaceutical medicine. 🎧 Subscribe for more conversations on radiopharmaceuticals, precision medicine, oncology, targeted therapies, and advanced therapies. #Radiopharmaceuticals #RadioligandTherapy #Theranostics #PrecisionMedicine #Oncology #NuclearMedicine #Pharma #Biotech #HealthcareInnovation #RxForBiotech

What if AI could help women better understand their bodies and take control of their health before problems become crises? In this episode of #RxforBiotech, host Chris Leidli sits down with Kirsten Karchmer, Founder and CEO of Conceivable, to discuss the future of women's health, fertility, hormone health, and personalized medicine. After helping more than 10,000 women improve their fertility and reproductive health over the past 25 years, Kirsten is now building an AI-powered operating system designed to help women understand the root causes of health challenges rather than simply treating symptoms. From fertility and PCOS to fatigue, hormone imbalances, perimenopause, and menopause, Conceivable combines artificial intelligence, wearable data, lifestyle insights, and personalized coaching to help women make informed decisions about their health. In this episode, we discuss: • Why so many women feel dismissed by the healthcare system • The future of AI in women's health • Fertility treatment and reproductive health • Personalized medicine and hormone optimization • The role of wearables, biomarkers, and health data • Menopause, perimenopause, and healthy aging • How AI can help women become advocates for their own health • Why understanding the root cause matters more than treating symptoms Whether you're trying to conceive, navigating hormone changes, managing a chronic condition, or simply interested in the future of healthcare, this conversation offers an inspiring look at how technology can empower women throughout every stage of life. 🎧 Subscribe for more conversations on healthcare innovation, precision medicine, AI, women's health, and advanced therapies.

What if the future of multiple sclerosis treatment could go beyond suppressing inflammation - and actually help protect the brain? In this episode of Rx for Biotech, host Chris Leidli sits down with Jason Tardio, President & COO of Immunic Therapeutics, to discuss the evolving future of treatment for Multiple Sclerosis (MS), one of the most complex autoimmune and neurodegenerative diseases affecting millions worldwide. Jason shares his deep experience leading major MS franchises at Biogen and Novartis, explains how MS attacks the brain and spinal cord, and breaks down why many current therapies focus primarily on inflammation but may not fully address the neurodegeneration driving long-term disability. The conversation also explores Immunic’s lead investigational therapy, vidofludimus calcium, an oral once-daily treatment being studied in Phase 3 clinical trials for relapsing multiple sclerosis. The company believes the therapy may offer a unique dual approach by targeting both neuroinflammation and neurodegeneration. Topics discussed include: • What causes multiple sclerosis • Early symptoms and diagnosis of MS • How MRI imaging transformed MS care • Why MS remains difficult to treat • The difference between inflammation and neurodegeneration • Oral therapies vs infusions and injectables • Progressive multiple sclerosis and unmet patient needs • The future of neuroscience, immunotherapy, and personalized medicine For patients, caregivers, healthcare providers, and anyone interested in the future of neurology and autoimmune disease treatment, this episode offers an accessible and hopeful look at where MS care may be headed next.

What if your own immune cells could be engineered to fight and even cure cancer? In this episode of Rx for Biotech, host Chris Leidli sits down with Navneet Majhail, MD, a leading expert in blood cancers, bone marrow transplants, and CAR-T cell therapy, to break down one of the most powerful innovations in modern medicine: CAR-T therapy. CAR-T therapy is a form of immunotherapy that uses a patient’s own T cells - engineered in a lab - to recognize and destroy cancer. It has already transformed outcomes for patients with leukemia, lymphoma, and multiple myeloma, offering hope where few options previously existed. But despite its promise, many eligible patients still don’t receive CAR-T therapy due to barriers like access, geography, insurance, and care coordination. In this conversation, Dr. Majhail explains: • What CAR-T cell therapy is and how it works • Why access to treatment remains a major challenge • The role of bone marrow transplant and cellular therapy networks • How care is shifting closer to home through community-based treatment models • The importance of caregivers and support systems during treatment • What the future holds for CAR-T in solid tumors, autoimmune diseases, and beyond This episode is a must-watch for patients, caregivers, and anyone interested in the future of personalized cancer treatment, immunotherapy, and advanced therapies

Why is brain cancer so hard to detect and treat - and what if we could change that? In this episode of Rx for Biotech, host Chris Leidli sits down with Marc Hedrick, CEO of Plus Therapeutics, and Russell Bradley, General Manager of CNSide Diagnostics, to explore a new, integrated approach to treating some of the most challenging cancers in medicine: central nervous system (CNS) cancers, including glioblastoma and leptomeningeal metastases. Brain and CNS cancers are among the most difficult to treat because of the blood-brain barrier, which prevents most drugs from reaching tumors. In fact, only a small percentage of therapies can effectively cross into the brain—limiting treatment options and outcomes. Plus Therapeutics is tackling this problem with a novel approach using targeted radiation therapy delivered directly to tumors, bypassing the blood-brain barrier. Their lead program uses a radioactive isotope (rhenium-186) delivered via nanoliposomes, allowing high doses of radiation to reach the tumor while minimizing damage to the rest of the body. At the same time, CNSide Diagnostics is helping physicians detect cancer earlier and monitor treatment response using an advanced cerebrospinal fluid (CSF) diagnostic test. This highly sensitive test can identify even small numbers of tumor cells—helping doctors make faster, more informed treatment decisions. Together, this combination of diagnostics + therapeutics + data represents a new model for precision oncology and personalized cancer care. In this episode, we discuss: • Why brain cancer is so difficult to treat • The role of the blood-brain barrier in limiting therapies • How targeted radiation therapy can improve outcomes • The importance of early detection and diagnostics • How monitoring tumor cells can guide treatment decisions • The future of integrated cancer care (theranostics) This conversation offers a powerful look at how innovation in both treatment and diagnostics could help improve survival and quality of life for patients with some of the most aggressive cancers.

What if you could get a Transplant and Reset your Immune System in less than 48 Hours? In this episode of Rx for Biotech, host Chris Leidli sits down with Kevin Caldwell, CEO of Ossium Health, to explore how bone marrow transplants, cell therapy, and bioengineered immune systems are transforming the future of medicine. Ossium Health is building a first-of-its-kind bone marrow banking platform, using donor-derived cells to make life-saving treatments available on demand. Traditionally, patients can wait months to find a donor match - time many simply don’t have. Ossium is changing that by enabling transplants in as little as 48 hours, dramatically improving access to care. In this conversation, Kevin explains how bone marrow transplants work, why they are one of the most powerful tools in modern medicine, and how replacing a patient’s blood and immune system can treat diseases like blood cancers and immune disorders. We also dive into: • Why most eligible patients never receive a bone marrow transplant • How off-the-shelf cell therapy could scale life-saving treatments • The role of the immune system in preventing disease and cancer • How donor-derived cells could unlock the future of regenerative medicine and longevity • Why improving immune health may be one of the most powerful ways to extend human life As cell therapy and regenerative medicine continue to evolve, Ossium’s approach could help shift healthcare from reactive treatment to proactive, personalized immune system care. 📌 Learn more about how to navigate the healthcare system and find the right specialists: https://therapy4me.ai

What if chemotherapy could target tumors without harming the rest of the body? In this episode of *Rx for Biotech*, host Chris Leidli sits down with Christina Coughlin, MD, PhD, CEO of Avacta Therapeutics, to explore a new approach to cancer treatment using targeted chemotherapy and precision oncology. Avacta is developing a novel platform designed to activate powerful cancer drugs only inside the tumor, potentially reducing side effects like damage to the heart, bone marrow, and other healthy tissues. This approach, known as tumor-targeted drug delivery, could redefine how chemotherapy is used across cancers such as triple-negative breast cancer, soft tissue sarcoma, and salivary gland cancer. Christina shares her journey from early work in CAR-T cell therapy and immuno-oncology to leading Avacta’s innovative pre|CISION peptide drug conjugate platform, including its lead asset AVA6000 (faridoxorubicin) now in clinical trials. In this conversation, we discuss: • How targeted chemotherapy works and why it may be safer than traditional chemo • The role of the immune system and immunotherapy in cancer treatment • Why improving drug delivery is one of the biggest challenges in oncology • Key clinical insights from early trials of AVA6000 • What the future of precision medicine and personalized cancer care could look like As cancer treatment evolves, innovations like Avacta’s platform could help patients receive more effective, less toxic therapies tailored to their biology 📌 Learn more about navigating advanced therapies and personalized care at: [https://www.therapy4me.ai] #CancerTreatment #PrecisionMedicine #Chemotherapy #Immunotherapy #Oncology #Biotech #TargetedTherapy #Avacta #RxForBiotech