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Dr. Mike Hart sits down with Dr. Jessica Peatross to explore the overlooked factors that may contribute to unexplained health symptoms, from blood sugar fluctuations that resemble anxiety to disrupted cortisol rhythms that affect sleep and energy. They discuss how meal timing, fasting, and hormone balance influence overall well-being, along with the relationship between gut health, histamine intolerance, and mast cell activation syndrome (MCAS). Dr. Jess explains why she questions conventional food sensitivity testing, how she evaluates potential liver dysfunction and mold exposure, and why certain probiotics and supplements may not work for everyone. The conversation also covers environmental toxins, breast implant illness, genetic variations such as MTHFR and COMT, and the importance of tailoring health interventions to individual needs. Dr. Jessica Peatross, also known as Dr. Jess, is a medical doctor and former hospitalist who spent nearly seven years practicing conventional medicine before transitioning toward a more holistic, individualized approach to patient care. Her work focuses on identifying underlying contributors to chronic health concerns through detailed patient histories, symptom patterns, laboratory assessments, and personalized treatment strategies. She emphasizes nervous system regulation, nutritional support, and understanding how environmental and biological factors influence individual health responses. Beyond her clinical practice, she shares educational content through her Wellness+ platform and serves as a supplement formulator for Aegis Formulas. Her philosophy encourages patients to look beyond symptom management while recognizing the essential role of conventional medicine, particularly in emergencies.   Dr. Jess MD (Official Website & Consultations) — Dr. Jessica Peatross https://drjess.health/ WellnessPlus (Health Education Platform) — Dr. Jessica Peatross https://wellnessplus.com/ Aegis Formulas (Supplement Company) — Dr. Jessica Peatross https://shop.aegisformulas.com/ TUDCA Max (Liver & Bile Support) — Aegis Formulas https://shop.aegisformulas.com/products/tudca-max Total Tox Binder — Aegis Formulas https://shop.aegisformulas.com/products/total-tox-binder DUTCH Cortisol Awakening Response Test — Precision Analytical https://dutchtest.com/product-information-sheets/cortisol-awakening-response-car-information-sheet Hormone Zoomer (Hormone Testing) — Vibrant Wellness https://vibrant-wellness.com/tests/hormone-zoomer Environmental Relative Moldiness Index (ERMI) — U.S. Environmental Protection Agency https://www.epa.gov/air-research/environmental-relative-moldiness-index-ermi Urine Mycotoxin Testing Information — Centers for Disease Control and Prevention https://www.cdc.gov/mmwr/preview/mmwrhtml/mm6406a7.htm Dr. Jess MD (Instagram) — Dr. Jessica Peatross https://www.instagram.com/dr.jess.md/ Dr. Jessica Peatross (YouTube) — Dr. Jessica Peatross https://www.youtube.com/@DoctorJessMD   Show Notes   00:00 Welcome to the Hart2Heart Podcast 00:32 Meet Dr Jess Journey 03:36 Panic Or Blood Sugar 04:30 Protein Fiber Meal Timing 06:12 Fasting Women Hormones 08:32 Waking At Three AM 09:39 Cortisol Melatonin Testing 12:13 Liver Stagnation Clues 14:03 TUDCA Bile Brain Benefits 16:00 Adrenal Fatigue Explained 16:59 Hormones DHEA Testosterone 18:57 Mast Cell Activation Basics 20:43 Treating Histamine Flares 23:37 Sudden Food Reactions 24:39 Peptides For Gut Repair 25:34 Oral Peptides Reality Check 27:17 Gut Brain Mood Connection 29:05 Probiotics Ferments Fiber 30:39 Food Sensitivity Tests Myth 33:18 Mold Symptoms And Diagnosis 36:08 Mold Detox Order Operations 38:33 Binders Sauna Detox Tips 40:10 Everyday Carcinogen Exposures 41:41 Breast Implant Illness Genes 44:32 MTHFR Overmethylation Pitfalls 46:16 Rapid Fire Final Questions 49:05 Closing Where To Find Dr Jess   The Hart2Heart podcast is hosted by family physician Dr. Michael Hart, who is dedicated to cutting through the noise and uncovering the most effective strategies for optimizing health, longevity, and peak performance.   This podcast dives deep into evidence-based approaches to hormone balance, peptides, sleep optimization, nutrition, psychedelics, supplements, exercise protocols, leveraging sunlight, and de-prescribing pharmaceuticals — using medications only when absolutely necessary.   Beyond health science, we explore the intersection of public health and politics, exposing how policy decisions shape our health landscape and what actionable steps people can take to reclaim control over their well-being.   Guests range from out-of-the-box thinking physicians such as Dr. Casey Means (author of "Good Energy") and Dr. Roger Sehult (Medcram lectures) to public health experts such as Dr. Jay Bhattacharya (Director of the National Institutes of Health (NIH) and Dr. Marty Mckary  (Commissioner of the Food and Drug Administration (FDA) and high-profile names such as  Zuby and Mark Sisson (Primal Blueprint and Primal Kitchen).   If you're ready to take control of your health and performance, this podcast is for you.We cut through the jargon and deliver practical, no-BS advice that you can implement in your daily life, empowering you to make positive changes for your well-being.   Connect with Dr. Mike Hart Instagram: @drmikehart Twitter: @drmikehart Facebook: @drmikehart

In this solo Hart2Heart Podcast episode (focused on male androgenetic alopecia), Dr. Mike Hart reviews hair-loss treatments, emphasizing that regrowth is harder if follicles are gone after 12–18 months. He highlights minoxidil (topical or oral), noting similar efficacy between 2.5 mg and 5 mg oral dosing, comparable results between oral 5 mg and topical 5% twice daily, and that adding 0.01% tretinoin may allow once-daily topical use; combining oral and topical is unstudied but not necessarily dangerous. He advises avoiding systemic DHT blockers due to side effects, favoring 0.05% topical dutasteride for minimal blood DHT reduction, and recommends weekly microneedling (~0.75 mm) without applying products immediately after. As growth-factor adjuncts, he prioritizes PRP or placental exosomes, discusses limited evidence for ketoconazole shampoo and copper peptides, warns DHT-derived anabolic steroids won't be helped by dutasteride, and reviews emerging anti-androgen options and their systemic-risk concerns.   Oral vs. Topical Minoxidil for Hair Loss — Mariana Alvares Penha et al., JAMA Dermatology https://pubmed.ncbi.nlm.nih.gov/38598226/ Minoxidil and Tretinoin Combination Treatment — Hyo Seung Shin et al., American Journal of Clinical Dermatology https://pubmed.ncbi.nlm.nih.gov/17902730/ Topical Dutasteride 0.05% for Male Pattern Hair Loss — Veerendra Kumar Panuganti et al., Cureus https://pubmed.ncbi.nlm.nih.gov/40909044/ Ketoconazole 2% Shampoo for Hair Loss (Nizoral) — C. Piérard-Franchimont et al., Dermatology https://pubmed.ncbi.nlm.nih.gov/9669136/ Microneedling for Hair Regrowth — Rachita Dhurat et al., International Journal of Trichology https://pubmed.ncbi.nlm.nih.gov/23960389/ Platelet-Rich Plasma (PRP) for Hair Loss — C. Donnelly et al., Journal of Cosmetic Dermatology https://pubmed.ncbi.nlm.nih.gov/38284294/ Exosomes for Hair Regeneration — Mohammed A. Al Ameer et al., Clinical, Cosmetic and Investigational Dermatology https://pubmed.ncbi.nlm.nih.gov/40955427/ AHK-Cu Copper Peptide and Hair Growth Research — Hyun Keol Pyo et al., Archives of Pharmacal Research https://pubmed.ncbi.nlm.nih.gov/17703734/ Emerging Hair Loss Treatments: Clascoterone and Pyrilutamide — Shivali Devjani et al., Drugs https://pubmed.ncbi.nlm.nih.gov/37166619/ GT20029: Emerging Hair Loss Treatment — Ruiming Hu et al., Journal of Dermatological Treatment https://pubmed.ncbi.nlm.nih.gov/41328006/   Show Notes 00:00 Welcome to the Hart2Heart Podcast 00:34 Podcast Intro and Scope 01:56 Realistic Regrowth Expectations 02:47 Minoxidil Dosing and Use 07:23 Topical Dutasteride Strategy 11:26 Adjunct Shampoo Option 12:16 Microneedling Done Right 14:55 PRP and Exosomes Boosters 16:47 Copper Peptides Hype Check 19:05 Other Add Ons and Big Four Recap 20:16 Steroids and DHT Reality 22:32 Future Anti Androgen Treatments 28:12 Wrap Up and Final Takeaways   The Hart2Heart podcast is hosted by family physician Dr. Michael Hart, who is dedicated to cutting through the noise and uncovering the most effective strategies for optimizing health, longevity, and peak performance. This podcast dives deep into evidence-based approaches to hormone balance, peptides, sleep optimization, nutrition, psychedelics, supplements, exercise protocols, leveraging sunlight, and de-prescribing pharmaceuticals — using medications only when absolutely necessary. Beyond health science, we explore the intersection of public health and politics, exposing how policy decisions shape our health landscape and what actionable steps people can take to reclaim control over their well-being. Guests range from out-of-the-box thinking physicians such as Dr. Casey Means (author of "Good Energy") and Dr. Roger Sehult (Medcram lectures) to public health experts such as Dr. Jay Bhattacharya (Director of the National Institutes of Health (NIH) and Dr. Marty Mckary  (Commissioner of the Food and Drug Administration (FDA) and high-profile names such as  Zuby and Mark Sisson (Primal Blueprint and Primal Kitchen). If you're ready to take control of your health and performance, this podcast is for you.We cut through the jargon and deliver practical, no-BS advice that you can implement in your daily life, empowering you to make positive changes for your well-being.   Connect with Dr. Mike Hart Instagram: @drmikehart Twitter: @drmikehart Facebook: @drmikehart

Dr. Mike Hart and Dr. Ira Price explore how medicine is adapting as patients gain greater access to emerging treatments, health information, and tools once limited to physicians. They discuss unapproved peptides and GLP-1 drugs, the growing shift toward personalized and patient-centered care, and the challenges doctors face when evidence and regulation lag behind real-world use. The conversation expands into Canada's opioid crisis, drug decriminalization, fentanyl and medetomidine contamination, emergency-room strain, physician burnout, and broader problems within the Canadian healthcare system. They also examine medical cannabis, CBD and lesser-known cannabinoids, psychedelic medicine, sleep, longevity, and the importance of balancing individual choice with evidence, clinical judgment, and responsible medical guidance. Dr. Ira Price is an emergency physician, sports medicine specialist, and longtime cannabinoid-medicine practitioner whose work sits at the intersection of acute care, emerging therapeutics, and patient-centered medicine. Over nearly two decades working with cannabinoids and years on the front lines of emergency care, he has developed a strong focus on helping patients navigate treatments that often move faster than traditional medical guidelines. His approach emphasizes collaboration rather than gatekeeping, encouraging physicians to remain lifelong learners while helping patients critically evaluate evidence, understand risks and benefits, and make more informed decisions about their health. He brings a practical perspective shaped by emergency medicine, sports medicine, cannabinoid research and clinical practice, and firsthand experience with the evolving challenges facing modern healthcare.   Medical Cannabis or Cannabinoids for Chronic Non-Cancer and Cancer Related Pain — Li Wang et al., including Dr. Ira Price / The BMJ H2H 241 IRA PRICE TRANSCRIPT BMJ https://www.bmj.com/content/374/bmj.n1034 Therapeutic Potential of Cannabidiol (CBD) in Anxiety Disorders: A Systematic Review and Meta-Analysis — Kevin Han, Jia-Yu Wang, Peng-Yun Wang & Yue-Chu-Han Peng H2H 241 IRA PRICE TRANSCRIPT PubMed https://pubmed.ncbi.nlm.nih.gov/38924898/ EPIDIOLEX (Cannabidiol) — Jazz Pharmaceuticals H2H 241 IRA PRICE TRANSCRIPT EPIDIOLEX.com https://www.epidiolex.com/what-is-epidiolex Acute Effects of Cannabigerol on Anxiety, Stress, and Mood — Carrie Cuttler, Amanda Stueber, Ziva D. Cooper & Ethan Russo / Scientific Reports H2H 241 IRA PRICE TRANSCRIPT PubMed https://pubmed.ncbi.nlm.nih.gov/39003387/ CBD and THCV in Patients With Type 2 Diabetes — Khalid A. Jadoon et al. / Diabetes Care H2H 241 IRA PRICE TRANSCRIPT PubMed https://pubmed.ncbi.nlm.nih.gov/27573936/ Dependence Potential and Acute Toxicity of Psychoactive Substances — Robert S. Gable / American Journal of Drug and Alcohol Abuse H2H 241 IRA PRICE TRANSCRIPT PubMed https://pubmed.ncbi.nlm.nih.gov/8213692/ Tru Niagen / Nicotinamide Riboside (NR) — Niagen Bioscience / Dr. Charles Brenner H2H 241 IRA PRICE TRANSCRIPT Tru Niagen https://www.truniagen.com/pages/our-story Oura Ring Sleep Tracking — Oura Health H2H 241 IRA PRICE TRANSCRIPT Oura Support https://support.ouraring.com/hc/en-us/articles/11752397946003-Sleep-Stages   Show Notes 00:00 Welcome to the Hart2Heart Podcast 02:04 Peptides Are Everywhere 04:01 GLP-1s Disrupt Weight Loss 08:02 Metformin Longevity Debate 10:41 Doctors Handling Unapproved GLPs 17:17 Patient Power And Education 21:31 Misinformation And Collaboration 25:02 Canadian Drug Policy Overhaul 31:37 Fentanyl Lacing Medetomidine 36:23 Why Healthcare Is Failing 41:01 ER Burnout And Wellness 43:17 Physician Self Care 43:39 Residency Grind Reality 44:23 Fixing Resident Hours 45:34 ER Career Longevity 47:05 Private Healthcare Debate 51:07 Immigration System Strain 53:24 CBD Hype vs Evidence 56:53 CBD Dosing and Cost 01:00:39 Buspirone and Psychedelics 01:08:24 Underrated Cannabinoids 01:12:54 Cannabis Sleep and REM 01:19:03 Cannabis Risks and Alcohol 01:24:47 Closing Thoughts   The Hart2Heart podcast is hosted by family physician Dr. Michael Hart, who is dedicated to cutting through the noise and uncovering the most effective strategies for optimizing health, longevity, and peak performance. This podcast dives deep into evidence-based approaches to hormone balance, peptides, sleep optimization, nutrition, psychedelics, supplements, exercise protocols, leveraging sunlight, and de-prescribing pharmaceuticals — using medications only when absolutely necessary. Beyond health science, we explore the intersection of public health and politics, exposing how policy decisions shape our health landscape and what actionable steps people can take to reclaim control over their well-being. Guests range from out-of-the-box thinking physicians such as Dr. Casey Means (author of "Good Energy") and Dr. Roger Sehult (Medcram lectures) to public health experts such as Dr. Jay Bhattacharya (Director of the National Institutes of Health (NIH) and Dr. Marty Mckary  (Commissioner of the Food and Drug Administration (FDA) and high-profile names such as  Zuby and Mark Sisson (Primal Blueprint and Primal Kitchen). If you're ready to take control of your health and performance, this podcast is for you.We cut through the jargon and deliver practical, no-BS advice that you can implement in your daily life, empowering you to make positive changes for your well-being.   Connect with Dr. Mike Hart Instagram: @drmikehart Twitter: @drmikehart Facebook: @drmikehart

Dr. Mike Hart sits down with lipidologist Dr. Spencer Nadolsky for a practical discussion on cardiovascular prevention, cholesterol management, and metabolic health. They break down how to interpret ApoB, LDL, HDL, triglycerides, and Lp(a), when cholesterol-lowering medications may make sense, and why long-term exposure matters when thinking about heart disease risk. The conversation also explores statins, PCSK9 inhibitors, plaque progression, supplements, insulin resistance, and the evolving role of GLP-1 medications in obesity treatment and long-term cardiometabolic health. Dr. Spencer Nadolsky is a physician specializing in obesity medicine, lipidology, and cardiometabolic health, with a strong focus on preventing chronic disease before it develops. His approach combines evidence-based medicine with individualized risk assessment, helping patients make sense of cholesterol, metabolic health, body weight, medications, and lifestyle without relying on one-size-fits-all recommendations. Known for translating complex medical research into practical guidance, he emphasizes sustainable health decisions, meaningful clinical outcomes, and finding the balance between being proactive about longevity and becoming overly consumed by it.   SAMSON Trial: Statin, Placebo, and No Treatment — James P. Howard et al. / Imperial College London https://pubmed.ncbi.nlm.nih.gov/34531021/   Multi-Ethnic Study of Atherosclerosis (MESA) — National Heart, Lung, and Blood Institute / NIH https://www.nhlbi.nih.gov/science/multi-ethnic-study-atherosclerosis-mesa   Framingham Heart Study Offspring Cohort — National Heart, Lung, and Blood Institute / BioLINCC https://biolincc.nhlbi.nih.gov/studies/framoffspring/   Repatha (Evolocumab) — Amgen https://www.repatha.com/resources-and-support   Ezetimibe — Mark Cuban Cost Plus Drug Company https://www.costplusdrugs.com/medications/ezetimibe-10mg-tablet/   Rosuvastatin — Mark Cuban Cost Plus Drug Company https://www.costplusdrugs.com/medications/rosuvastatin-10mg-tablet/   Psyllium Fiber / Metamucil — Procter & Gamble / Metamucil https://www.metamucil.com/en-us/articles/psyllium-fiber/psyllium-fiber-in-metamucil   Docs Who Lift Podcast — Dr. Spencer Nadolsky & Dr. Karl Nadolsky https://docswholift.com/podcast/   Vineyard — Dr. Spencer Nadolsky https://joinvineyard.com/   Dr. Spencer Nadolsky on Instagram — Dr. Spencer Nadolsky https://www.instagram.com/drnadolsky/   Dr. Spencer Nadolsky on X — Dr. Spencer Nadolsky https://x.com/DrNadolsky Show Notes   00:00 Welcome to the Hart2Heart Podcast 00:29 Reconnecting And Lipids Focus 00:46 Why Switch To Repatha 02:42 Diet Limits And ApoB Goals 04:03 Ezetimibe And Statin Rationale 05:07 Family History Wake Up Call 06:26 Nocebo And Cleaner PCSK9 10:31 Lp Little A Not A Factor 11:47 Oura Ring And Biohacker Stress 13:33 Dropping Pitavastatin And CoQ10 17:20 Bempedoic Acid And Combo Therapy 20:18 LDL ApoB Discordance Explained 23:37 How Low Is Too Low 26:10 Optimal Targets And When To Start 29:13 Can Ultra Low Prevent Plaque 31:09 Why People Ignore Cholesterol 32:23 Can Plaque Regress 33:16 Vitamin K2 Reality Check 34:00 Mechanisms vs Outcomes 34:58 Lp(a) Drug Disappointment 37:08 How to Use Lp(a) 40:23 HDL Myths Explained 43:11 Triglycerides and Insulin 45:35 Oxidized LDL and NMR 47:33 Supplements That Matter 48:51 Berberine Benefits and Risks 51:50 GLP-1 Stacking Debate 56:41 Microdosing and Plateaus 59:34 Longevity and Alcohol Effects 01:00:36 Future of Anti Obesity Drugs 01:02:00 Wrap Up and Where to Find   The Hart2Heart podcast is hosted by family physician Dr. Michael Hart, who is dedicated to cutting through the noise and uncovering the most effective strategies for optimizing health, longevity, and peak performance. This podcast dives deep into evidence-based approaches to hormone balance, peptides, sleep optimization, nutrition, psychedelics, supplements, exercise protocols, leveraging sunlight, and de-prescribing pharmaceuticals — using medications only when absolutely necessary. Beyond health science, we explore the intersection of public health and politics, exposing how policy decisions shape our health landscape and what actionable steps people can take to reclaim control over their well-being. Guests range from out-of-the-box thinking physicians such as Dr. Casey Means (author of "Good Energy") and Dr. Roger Sehult (Medcram lectures) to public health experts such as Dr. Jay Bhattacharya (Director of the National Institutes of Health (NIH) and Dr. Marty Mckary  (Commissioner of the Food and Drug Administration (FDA) and high-profile names such as  Zuby and Mark Sisson (Primal Blueprint and Primal Kitchen). If you're ready to take control of your health and performance, this podcast is for you.We cut through the jargon and deliver practical, no-BS advice that you can implement in your daily life, empowering you to make positive changes for your well-being.   Connect with Dr. Mike Hart Instagram: @drmikehart Twitter: @drmikehart Facebook: @drmikehart

Dr. Mike Hart discusses how oral peptides can still have biological effects despite limited or no systemic absorption, using examples including KPV, BPC-157, linaclotide (Constella), oral semaglutide, and cyclosporine. He explains protein digestion into dipeptides/tripeptides and the PEPT1 transporter that moves some small peptides into enterocytes for local cellular effects, noting that KPV can act in intestinal cells without entering circulation and that carnosine is another PEPT1-absorbed example. He outlines multiple local mechanisms (acting in the gut lumen, on the enterocyte surface, inside enterocytes, and in nearby gut tissue) and contrasts these with systemic absorption examples like semaglutide formulated with SNAC (only 0.4–1% reaches blood yet remains effective) and cyclosporine's unusual properties. He notes exceptions like glutathione and discusses theories for BPC-157's oral effects, emphasizing regulated products and upcoming discussion on GLP-1s and obesity with Dr. Spencer Nadolsky.   LINZESS (Linaclotide) Prescribing Information — DailyMed, U.S. National Library of Medicine (dailymed.nlm.nih.gov) https://dailymed.nlm.nih.gov/dailymed/search.cfm?labeltype=all&query=linaclotide PepT1-Mediated Tripeptide KPV Uptake Reduces Intestinal Inflammation — Gastroenterology / PubMed, U.S. National Library of Medicine (PubMed) https://pubmed.ncbi.nlm.nih.gov/18061177/ The Oligopeptide Transporter PEPT1 in Human Intestine — PubMed, U.S. National Library of Medicine (PubMed) https://pubmed.ncbi.nlm.nih.gov/9207295/ Oral Semaglutide (RYBELSUS) Prescribing Information — Novo Nordisk / DailyMed, U.S. National Library of Medicine (DailyMed) https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=27f15fac-7d98-4114-a2ec-92494a91da98 Transcellular Stomach Absorption of Oral Semaglutide With SNAC — Science Translational Medicine / PubMed (PubMed) https://pubmed.ncbi.nlm.nih.gov/30429357/ BPC-157 Oral Administration and Gastrointestinal Healing Research — University of Zagreb / PubMed (PubMed) https://pubmed.ncbi.nlm.nih.gov/18818478/ Cyclosporine Oral Prescribing Information — DailyMed, U.S. National Library of Medicine (DailyMed) https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=bfca7088-fe93-abb9-3ec3-e6f5710a69c6   Show Notes   00:00 Welcome to the Hart2Heart Podcast 00:52 Oral Peptides Mythbusting 02:37 Protein Digestion Basics 03:31 PEPT1 Absorption Pathway 04:39 KPV and Carnosine Examples 06:12 Glutathione Exception 07:38 Garden Hose Local Actions 08:26 Linaclotide IBS Mechanism 09:37 Four Local Action Sites 11:25 SNAC Enables Blood Levels 13:26 Cyclosporine Oral Exception 14:35 Other Minor Pathways 15:43 BPC 157 Oral Mystery 18:10 Wrap Up and Safety Notes 19:57 Closing and Next Episode   The Hart2Heart podcast is hosted by family physician Dr. Michael Hart, who is dedicated to cutting through the noise and uncovering the most effective strategies for optimizing health, longevity, and peak performance. This podcast dives deep into evidence-based approaches to hormone balance, peptides, sleep optimization, nutrition, psychedelics, supplements, exercise protocols, leveraging sunlight, and de-prescribing pharmaceuticals — using medications only when absolutely necessary. Beyond health science, we explore the intersection of public health and politics, exposing how policy decisions shape our health landscape and what actionable steps people can take to reclaim control over their well-being. Guests range from out-of-the-box thinking physicians such as Dr. Casey Means (author of "Good Energy") and Dr. Roger Sehult (Medcram lectures) to public health experts such as Dr. Jay Bhattacharya (Director of the National Institutes of Health (NIH) and Dr. Marty Mckary  (Commissioner of the Food and Drug Administration (FDA) and high-profile names such as  Zuby and Mark Sisson (Primal Blueprint and Primal Kitchen). If you're ready to take control of your health and performance, this podcast is for you.We cut through the jargon and deliver practical, no-BS advice that you can implement in your daily life, empowering you to make positive changes for your well-being.   Connect with Dr. Mike Hart Instagram: @drmikehart Twitter: @drmikehart Facebook: @drmikehart

In this episode, Dr. Mike Hart and OB-GYN Dr. Salome Masghati examine how common hormone interventions can affect women far beyond pregnancy prevention or symptom relief. They discuss the risks and tradeoffs of different birth control options, possible effects on mood, libido, testosterone, and attraction, and why individual responses can vary significantly. The conversation then explores when to consider HRT, the roles of estrogen, progesterone, and testosterone, thyroid testing beyond TSH, and how shifting hormones may contribute to mast cell symptoms during perimenopause. The episode provides a practical framework for making more informed and personalized decisions about hormone care. Dr. Salome Masghati is a board-certified OB-GYN and functional gynecologist whose work focuses on individualized hormone care for women throughout their reproductive years, perimenopause, and menopause. Her approach combines symptoms, menstrual patterns, comprehensive laboratory testing, metabolic markers, and treatment response to understand each patient's complete health picture rather than relying on a single test or standardized protocol. She works with bioidentical and rhythmic hormone strategies, thyroid care, sexual wellness, and root-cause assessment, emphasizing informed choices, careful monitoring, and helping patients move beyond temporary symptom control toward better long-term health and function.   Dr. Salome Masghati Official Website — Dr. Salome Masghati, Precision Gynecology https://drsalomemasghati.com/ Dr. Salome Masghati on Instagram — Dr. Salome Masghati https://www.instagram.com/drsalomemasghatimd/ This Is Your Brain on Birth Control — Dr. Sarah E. Hill https://www.sarahehill.com/books/your-brain-on-birth-control/ Women's Health Initiative — National Heart, Lung, and Blood Institute, NIH https://www.nhlbi.nih.gov/science/womens-health-initiative-whi 2022 Hormone Therapy Position Statement — The North American Menopause Society https://menopause.org/wp-content/uploads/professional/nams-2022-hormone-therapy-position-statement.pdf Mortality Associated With Hormone Replacement Therapy — Shelley R. Salpeter et al. https://pubmed.ncbi.nlm.nih.gov/15209595/ Oral Contraceptives, SHBG, and Androgen Levels — Claudia Panzer et al. https://pubmed.ncbi.nlm.nih.gov/16409223/ Hormonal Contraceptive Discontinuation and Relationship Satisfaction — V. Michelle Russell et al. https://pubmed.ncbi.nlm.nih.gov/25404285/ Progestogen Use and Intracranial Meningioma Risk — Léa Hoisnard et al., The BMJ https://www.bmj.com/content/384/bmj-2023-078078 Physiologic Hormone Restoration Therapy — Women's Hormone Network https://womenshormonenetwork.org/traditional-versus-pr/ GlycanAge Biological Age Test — GlycanAge https://glycanage.com/   Show Notes   00:00 Welcome to the Hart2Heart Podcast 01:00 Birth Control Safety Overview 02:07 SHBG Testosterone Libido Risks 04:19 SSRIs And Sexual Side Effects 05:26 Depo Shot Meningioma Concerns 09:07 Choosing Alternatives And Counseling 12:40 Attraction Changes And Partner Choice 15:20 Doctor Personal Story Coming Off 19:15 Menopause HRT Fear And WHI 22:00 Estrogen Window For Heart Brain 24:12 HRT Longevity And Start Age 30:41 Testosterone For Women Benefits 33:06 Rhythmic Hormone Dosing Explained 35:30 Cycle-Based GLP-1 Dosing 37:12 Evidence for Rhythmic HRT 39:32 Hormone Cycling and Cancer Risk 41:13 Why Most Doctors Don't 42:58 Libido and Orgasm Tools 46:59 Thyroid Labs Beyond TSH 50:26 Thyroid Antibodies Strategy 54:59 Staying on HRT for Life 58:21 Bioidentical Hormone Choices 01:00:53 Progesterone Delivery Debate 01:02:50 Mast Cell Activation Explained 01:07:28 Wrap-Up and Where to Follow   The Hart2Heart podcast is hosted by family physician Dr. Michael Hart, who is dedicated to cutting through the noise and uncovering the most effective strategies for optimizing health, longevity, and peak performance. This podcast dives deep into evidence-based approaches to hormone balance, peptides, sleep optimization, nutrition, psychedelics, supplements, exercise protocols, leveraging sunlight, and de-prescribing pharmaceuticals — using medications only when absolutely necessary. Beyond health science, we explore the intersection of public health and politics, exposing how policy decisions shape our health landscape and what actionable steps people can take to reclaim control over their well-being. Guests range from out-of-the-box thinking physicians such as Dr. Casey Means (author of "Good Energy") and Dr. Roger Sehult (Medcram lectures) to public health experts such as Dr. Jay Bhattacharya (Director of the National Institutes of Health (NIH) and Dr. Marty Mckary  (Commissioner of the Food and Drug Administration (FDA) and high-profile names such as  Zuby and Mark Sisson (Primal Blueprint and Primal Kitchen). If you're ready to take control of your health and performance, this podcast is for you.We cut through the jargon and deliver practical, no-BS advice that you can implement in your daily life, empowering you to make positive changes for your well-being.   Connect with Dr. Mike Hart Instagram: @drmikehart Twitter: @drmikehart Facebook: @drmikehart

Dr. Mike Hart sits down with Dr. Ilon Choai to unpack everyday dental habits and the connection between oral and overall health. They discuss choosing toothpaste, fluoride versus nano-hydroxyapatite, and how mouthwash may affect the oral microbiome. Dr. Choai shares his approach to brushing, flossing, tongue scraping, and managing dietary acid exposure, while explaining teeth-whitening options, addressing root canal concerns, and outlining what to consider before getting veneers. Dr. Ilon Choai is a practicing dentist, the creator of NOBS oral care products, and a co-host of Down to Health. His work emphasizes preventive dentistry, patient education, and helping people build habits they can maintain beyond the dental chair. Known online as @thenobsdentist, he encourages informed conversations about dental products and treatment choices. His approach combines clinical care with an interest in moving dentistry beyond "drill, fill, and bill" toward a more integrated role in whole-body health.   NOBS Toothpaste Tablets — NOBS https://nobsroutines.com/products/nobs-toothpaste-tablets NOBS Herbal Mouthwash — NOBS https://nobsroutines.com/products/nobs-herbal-mouthwash Atomic Habits — James Clear https://jamesclear.com/atomic-habits Root Canal Discussion: "Is This Procedure Really Causing Cancer?" — Down to Health, featuring Dr. Valerie Kanter https://music.youtube.com/podcast/Vn-SH7qbvkw Relative Dentin Abrasivity (RDA) Explained — American Dental Association https://www.ada.org/resources/ada-library/oral-health-topics/toothpastes   Show Notes 00:00 Welcome to the Hart2Heart Podcast 01:08 Why Oral Health Matters 04:35 Choosing The Right Toothpaste 09:15 Why Whitening Toothpaste Fails 13:58 Key Toothpaste Ingredients 22:49 Hydroxyapatite And Fluoride 28:31 Electric Brushes And Technique 30:56 Waterpik Versus Flossing 34:32 Mouthwash Myths And Safer Picks 40:24 Acidic Mouthwash Risks 41:00 Tongue Scraping Basics 44:21 Nighttime Snacking Rules 45:48 Carbonated Drinks and pH 47:43 Mouth Breathing and Dry Mouth 50:39 Teeth Whitening Science 54:00 Whitening Options and Longevity 01:00:25 Dental Cleaning Ingredients 01:01:54 Fillings Materials and Safety 01:06:53 Root Canals Mythbusting 01:11:34 Veneers Hype and Downsides 01:16:37 Gum Disease and Heart Health 01:20:19 Ideal Oral Hygiene Plan 01:24:10 Where to Find NOBS   The Hart2Heart podcast is hosted by family physician Dr. Michael Hart, who is dedicated to cutting through the noise and uncovering the most effective strategies for optimizing health, longevity, and peak performance. This podcast dives deep into evidence-based approaches to hormone balance, peptides, sleep optimization, nutrition, psychedelics, supplements, exercise protocols, leveraging sunlight, and de-prescribing pharmaceuticals — using medications only when absolutely necessary. Beyond health science, we explore the intersection of public health and politics, exposing how policy decisions shape our health landscape and what actionable steps people can take to reclaim control over their well-being. Guests range from out-of-the-box thinking physicians such as Dr. Casey Means (author of "Good Energy") and Dr. Roger Sehult (Medcram lectures) to public health experts such as Dr. Jay Bhattacharya (Director of the National Institutes of Health (NIH) and Dr. Marty Mckary  (Commissioner of the Food and Drug Administration (FDA) and high-profile names such as  Zuby and Mark Sisson (Primal Blueprint and Primal Kitchen). If you're ready to take control of your health and performance, this podcast is for you.We cut through the jargon and deliver practical, no-BS advice that you can implement in your daily life, empowering you to make positive changes for your well-being. Connect with Dr. Mike Hart Instagram: @drmikehart Twitter: @drmikehart Facebook: @drmikehart

In this episode, Dr. Mike Hart sits down with Lee Whitley and physician Dr. Ira Price for a wide-ranging discussion about Lee's proprietary cannabis formulation and the extraordinary cancer-treatment claims surrounding it. Lee shares his own experience with stage IV squamous cell throat cancer, patient case stories, oral and injectable applications, dosing, and alleged pharmaceutical acquisition offers, while Dr. Price separates what he has personally observed from what has yet to be established through rigorous research. The conversation explores cannabinoids, THC, CBD, terpenes, chemotherapy and radiation, pathology and imaging, the limitations of anecdotal evidence, and the regulatory, funding, and data-access barriers standing between individual case reports and credible clinical trials.  Lee Whitley is an entrepreneur and the creator of Lee's Oil and Lee Helps, a cannabis-based project that grew out of his personal experience with cancer and his years of developing and refining a proprietary cannabis formulation. He has since become an outspoken advocate for studying the results he says he has observed through formal clinical research. Dr. Ira Price is a physician with nearly two decades of experience prescribing cannabinoids and researching medical cannabis, including published work on cannabis for opioid substitution and years of lecturing internationally on cannabinoid medicine. Together, Whitley and Dr. Price bring two very different perspectives to the conversation—one shaped by personal experience and unconventional experimentation, and the other by clinical practice, scientific skepticism, and a focus on evidence, regulation, and properly designed trials. Lee Helps / Lee's Oil — Lee Whitley https://leehelps.com/ Cannabis for Opioid Substitution Trial (COST) — Dr. Ira Price / Cannabis Research Associates https://clinicaltrials.gov/study/NCT03859089 Cannabis Research Licensing — Health Canada https://www.canada.ca/en/health-canada/services/drugs-medication/cannabis/industry-licensees-applicants/research-licensing-application.html   Clinical Trials With Cannabis — Health Canada https://www.canada.ca/en/health-canada/services/drugs-health-products/drug-products/announcements/notice-clarification-requirements-conducting-clinical-trials-cannabis.html Human Health Therapeutics Research Centre — National Research Council Canada https://www.nrc.canada.ca/en/research-development/research-collaboration/research-centres/human-health-therapeutics-research-centre   Prescribing Drugs Policy — College of Physicians and Surgeons of Ontario (CPSO) https://www.cpso.on.ca/physicians/policies-guidance/policies/prescribing-drugs 4-Year-Old Cancer Case With 132 Tumors — Lee Whitley / Shit My Dad Taught Me https://www.iheart.com/podcast/1323-shit-my-dad-taught-me-264023145/episode/ep-22-lee-whitley-286273525/ Lee Helps Cancer & Melanoma Testimonials — Lee Whitley / Lee Helps Oil https://www.leehelpsoil.com/   Show Notes 00:00 Welcome to the Hart2Heart Podcast 00:29 Claimed Cure Rates 01:59 Doctor Skepticism 03:47 Four Year Old Case 06:40 Colon Cancer Testimonial 09:43 Lee Cancer Story 14:28 Injection Timeline 16:00 Formula Breakdown 18:28 Terpenes Explained 21:29 Rick Simpson Comparison 24:52 How It Works 27:43 Chemo Radiation Debate 33:20 Injections Vs Pills 36:42 Research Roadblocks 44:03 Trial Plans Abroad 44:34 30 Women Trial Plan 46:02 Study Design Debate 47:23 Dosing Protocol Details 48:43 Big Pharma Buyout Claims 51:50 Suppression And Threats 55:12 What Happens After Success 57:59 Finding Patients And Reach 59:48 Treating More Than Cancer 01:06:51 How The Plant Was Found 01:13:47 Chemo Radiation Clash 01:17:59 Timeline And Publication 01:20:27 Closing Advice And Wrap   The Hart2Heart podcast is hosted by family physician Dr. Michael Hart, who is dedicated to cutting through the noise and uncovering the most effective strategies for optimizing health, longevity, and peak performance. This podcast dives deep into evidence-based approaches to hormone balance, peptides, sleep optimization, nutrition, psychedelics, supplements, exercise protocols, leveraging sunlight, and de-prescribing pharmaceuticals — using medications only when absolutely necessary. Beyond health science, we explore the intersection of public health and politics, exposing how policy decisions shape our health landscape and what actionable steps people can take to reclaim control over their well-being. Guests range from out-of-the-box thinking physicians such as Dr. Casey Means (author of "Good Energy") and Dr. Roger Sehult (Medcram lectures) to public health experts such as Dr. Jay Bhattacharya (Director of the National Institutes of Health (NIH) and Dr. Marty Mckary  (Commissioner of the Food and Drug Administration (FDA) and high-profile names such as  Zuby and Mark Sisson (Primal Blueprint and Primal Kitchen). If you're ready to take control of your health and performance, this podcast is for you.We cut through the jargon and deliver practical, no-BS advice that you can implement in your daily life, empowering you to make positive changes for your well-being.   Connect with Dr. Mike Hart Instagram: @drmikehart Twitter: @drmikehart Facebook: @drmikehart

In this episode, Dr. Mike Hart sits down with Dr. Leigh Erin Connealy for a wide-ranging conversation on cancer prevention and the factors she believes influence long-term health. Dr. Connealy shares her perspective on why cancer should be approached as a whole-body problem, exploring the roles of nutrition, metabolic health, environmental toxins, sleep, stress, hormones, and mitochondrial function. They also discuss fasting and ketogenic diets, cancer screening, GLP-1 medications, aspirin, peptides, medicinal mushrooms, IV vitamin C, and other integrative approaches, along with Dr. Connealy's concerns about conventional screening and treatment practices. Throughout the conversation, she emphasizes individualized care and looking beyond a diagnosis to understand the broader conditions affecting each patient.   Dr. Leigh Erin Connealy is a medical doctor with four decades of experience who takes a prevention-focused, whole-person approach to health, longevity, and complex chronic disease. Her work spans human optimization through advanced conditions including cancer, dementia, autoimmune disease, and Parkinson's, with an emphasis on identifying and addressing factors that may interfere with the body's ability to function optimally. Her approach was shaped in part by her own health journey after learning that she had been exposed before birth to DES (diethylstilbestrol), which led her to undergo ongoing evaluations at MD Anderson and explore medicine beyond conventional symptom-based care. Over her career, she has incorporated individualized laboratory assessment, natural hormones, nutrition, peptides, and other integrative strategies while emphasizing what she describes as "creating health" rather than simply treating a diagnosis.    [The Cancer Revolution] — Leigh Erin Connealy, MD / Hachette Book Group https://www.hachettebookgroup.com/titles/leigh-erin-connealy/the-cancer-revolution/9780306836688/ [Be Perfectly Healthy] — Leigh Erin Connealy, MD / Perfectly Healthy https://perfectlyhealthy.com/products/be-perfectly-healthy-1 [Celluverse Podcast] — Dr. Leigh Erin Connealy, Alannah Connealy & Jess Donovan https://podcasts.apple.com/us/podcast/celluverse/id1836455844 [Dr. Leigh Erin Connealy Instagram — @connealymd] — Leigh Erin Connealy, MD https://www.instagram.com/connealymd/ [Cologuard Plus] — Exact Sciences Corporation https://www.cologuard.com/resources [QTI Breast Acoustic CT Scanner] — QT Imaging Holdings, Inc. https://www.qtimaging.com/breast-acoustic-ct-scanner/ [UT MD Anderson Cancer Center] — The University of Texas MD Anderson Cancer Center https://www.mdanderson.org/ [Eminence Organic Skin Care — Sun Care] — Eminence Organic Skin Care https://eminenceorganics.com/us/face/sun-care [Primally Pure Sunscreen] — Primally Pure https://primallypure.com/pages/sunscreen [COOLA Sunscreen] — COOLA https://coola.com/collections/sunscreen   Show Notes 00:00 Welcome to the Hart2Heart Podcast 01:07 Root Cause Medicine 02:29 Is Cancer Preventable 05:42 Biggest Risk Factors 09:51 Toxins And Detox Testing 12:26 Sweating And Detox Baths 00:00 Doctors Not Listening 16:58 Does Sugar Feed Cancer 22:37 Fasting And Keto Strategies 26:05 Mushrooms And Supplements 27:21 Thiamine And Nutrient Gaps 29:35 Hormones And Cancer Risk 35:42 Complete Hormone Panels 38:02 GLP-1s and Cancer Risk 39:18 Daily Aspirin Debate 41:12 Peptides to Avoid 43:20 Russian Peptides Cycling 45:43 Non Toxic Sunscreen Choices 47:14 Deodorants and Aluminum 48:18 AirPods and Brain Health 50:26 Cancer Screening Strategy 54:30 Breast Imaging Options 56:05 Biopsy Spread Concerns 58:09 Why Medicine Misses Prevention 01:01:55 Personal DES Cancer Journey 01:03:10 IV Vitamin C for Cancer 01:04:26 Where to Follow and Book   The Hart2Heart podcast is hosted by family physician Dr. Michael Hart, who is dedicated to cutting through the noise and uncovering the most effective strategies for optimizing health, longevity, and peak performance. This podcast dives deep into evidence-based approaches to hormone balance, peptides, sleep optimization, nutrition, psychedelics, supplements, exercise protocols, leveraging sunlight, and de-prescribing pharmaceuticals — using medications only when absolutely necessary. Beyond health science, we explore the intersection of public health and politics, exposing how policy decisions shape our health landscape and what actionable steps people can take to reclaim control over their well-being. Guests range from out-of-the-box thinking physicians such as Dr. Casey Means (author of "Good Energy") and Dr. Roger Sehult (Medcram lectures) to public health experts such as Dr. Jay Bhattacharya (Director of the National Institutes of Health (NIH) and Dr. Marty Mckary  (Commissioner of the Food and Drug Administration (FDA) and high-profile names such as  Zuby and Mark Sisson (Primal Blueprint and Primal Kitchen). If you're ready to take control of your health and performance, this podcast is for you.We cut through the jargon and deliver practical, no-BS advice that you can implement in your daily life, empowering you to make positive changes for your well-being.   Connect with Dr. Mike Hart Instagram: @drmikehart Twitter: @drmikehart Facebook: @drmikehart

After a five-year hiatus, Dan Go returns to break down a sustainable approach to fat loss for busy people who do not have hours to spend in the gym. He explains why identifying the main physiological or psychological bottleneck—such as late-night eating, stress, grazing, or weekend overeating—can matter more than simply handing someone a meal plan. The conversation covers calorie tracking for awareness, protein and fiber for satiety, meal timing, restaurant strategies, preserving muscle with low-volume strength training, FFMI as an alternative to BMI, and a balanced view of GLP-1 medications that considers both their benefits and trade-offs. Dan Go is a fitness coach and entrepreneur whose work focuses on helping busy professionals, founders, and entrepreneurs improve their body composition, health, and performance through sustainable nutrition, behavior change, and efficient training. His coaching approach emphasizes identifying the specific habits, beliefs, and environmental factors that make fat loss difficult, then building practical systems and guardrails that clients can maintain long term. Rather than relying on extreme diets or high-volume workouts, he focuses on awareness, consistency, adequate protein, structured eating, and time-efficient strength training to help clients lose fat while preserving muscle. [Dan Go Official Website] — Dan Go (Dan Go) https://www.dango.co/ [The High Performance Journal] — Dan Go (Dan Go) https://www.dango.co/newsletter [Dan Go on X] — Dan Go (X (formerly Twitter)) https://x.com/CoachDanGo [Dan Go on Instagram] — Dan Go (Instagram) https://www.instagram.com/coachdango/ [Dan Go Private Coaching] — High Performance Founder / Dan Go (High Performance Founder) https://highperformancefounder.com/private-coaching [Why I Quit Drinking Alcohol] — Mark Manson (Mark Manson) https://markmanson.net/why-i-quit-drinking-alcohol [A Satiety Index of Common Foods] — S. H. Holt, J. C. Miller, P. Petocz & E. Farmakalidis (PubMed) https://pubmed.ncbi.nlm.nih.gov/7498104/ [Fat-Free Mass Index (FFMI) Research] — Loenneke et al. (PubMed Central (PMC)) https://pmc.ncbi.nlm.nih.gov/articles/PMC3445648/ [ChatGPT] — OpenAI (ChatGPT) https://chatgpt.com/ [Claude] — Anthropic (Claude) https://claude.com/ [Mounjaro (tirzepatide)] — Eli Lilly and Company (Mounjaro) https://mounjaro.lilly.com/ [Ozempic (semaglutide)] — Novo Nordisk (Ozempic) https://www.ozempic.com/   Show Notes   00:00 Welcome to the Hart2Heart Podcast 00:49 Rapid Fat Loss Setup 01:11 Find The Bottleneck 02:38 Late Night Eating Roots 04:21 Mark Manson Case Study 05:55 Metabolic Reset Phase 06:38 After Weight Loss Plan 09:29 Remove Obstacles First 10:59 Sustainable Diet Rules 13:03 No Cheat Meals 13:15 90 10 Ratio Diet 15:27 Tracking For Awareness 18:12 Calorie Blind Spots 19:45 Guardrails Not Counting 21:43 Satiety And Fiber 24:24 GLOP Protein Breakfast 28:36 Why Eat Breakfast 30:14 Breakfast Beats Stress 31:22 Night Eating Guardrails 32:53 Sleep and Late Meals 34:15 Restaurant Ordering Hacks 38:49 Keep Muscle While Cutting 45:30 FFMI Over BMI 47:31 GLP-1s Balanced Take 54:25 Dosing and Nutrition Guardrails 57:50 Men vs Women Fat Loss 59:58 Where to Find Dan Go   The Hart2Heart podcast is hosted by family physician Dr. Michael Hart, who is dedicated to cutting through the noise and uncovering the most effective strategies for optimizing health, longevity, and peak performance. This podcast dives deep into evidence-based approaches to hormone balance, peptides, sleep optimization, nutrition, psychedelics, supplements, exercise protocols, leveraging sunlight, and de-prescribing pharmaceuticals — using medications only when absolutely necessary. Beyond health science, we explore the intersection of public health and politics, exposing how policy decisions shape our health landscape and what actionable steps people can take to reclaim control over their well-being. Guests range from out-of-the-box thinking physicians such as Dr. Casey Means (author of "Good Energy") and Dr. Roger Sehult (Medcram lectures) to public health experts such as Dr. Jay Bhattacharya (Director of the National Institutes of Health (NIH) and Dr. Marty Mckary  (Commissioner of the Food and Drug Administration (FDA) and high-profile names such as  Zuby and Mark Sisson (Primal Blueprint and Primal Kitchen). If you're ready to take control of your health and performance, this podcast is for you.We cut through the jargon and deliver practical, no-BS advice that you can implement in your daily life, empowering you to make positive changes for your well-being.   Connect with Dr. Mike Hart Instagram: @drmikehart Twitter: @drmikehart Facebook: @drmikehart

Charles Brenner breaks down what the science actually says about NAD+, separating established findings from the claims commonly made in the longevity space. He explains why NAD levels in tissues may matter more than blood measurements, how metabolic stress, alcohol, inflammation, and other conditions can disrupt the NAD system, and how nicotinamide riboside (NR) compares with niacin, nicotinamide, and NMN. The conversation also covers research on exercise recovery, peripheral artery disease, skin health, infection, and wound healing, along with the limitations of current human evidence. Brenner explains why he advises against IV and subcutaneous NAD+, discusses concerns around NMN quality, and challenges popular sirtuin-centered theories of anti-aging while emphasizing the importance of reproducible human research. Charles Brenner is an NAD metabolism researcher whose work focuses on cellular bioenergetics, vitamin B3 biology, metabolic stress, and the pathways that regulate NAD production and utilization throughout the body. Now based at the University of Helsinki, his research has examined how the NAD system responds to conditions ranging from metabolic and liver disease to mitochondrial dysfunction, inflammation, and neurological stress. His work has also helped advance research into nicotinamide riboside as an NAD precursor and its potential applications in human health. Brenner takes an evidence-first approach to longevity science, distinguishing findings supported by controlled human studies from promising but still unproven mechanisms, animal research, and anecdotal claims.   Brenner Lab — Charles Brenner, PhD https://www.brennerlab.net/   Niagen NR Clinical Studies — Niagen Bioscience https://www.niagenbioscience.com/pages/clinical-studies   Nicotinamide Riboside for Peripheral Artery Disease — Mary M. McDermott et al. https://pubmed.ncbi.nlm.nih.gov/38871717/   This is the PAD study discussed in the episode where NR improved six-minute walking performance.   NOPARK: Nicotinamide Riboside in Early Parkinson's Disease — Haukeland University Hospital / Norwegian Research Team https://clinicaltrials.gov/study/NCT03568968   This is the 400-participant, 52-week Parkinson's trial discussed in the transcript.   Effects of Nicotinamide Riboside in Long COVID — Chao-Yi Wu, Edmarie Guzmán-Vélez, Charles Brenner et al. https://www.thelancet.com/journals/eclinm/article/PIIS2589-5370%2825%2900567-X/fulltext   This is the Long COVID study Brenner references when discussing cognition, fatigue, sleep, and symptom recovery.   NAD+ Metabolome in Alcohol-Related Liver Disease — Richard Parker, Charles Brenner et al. https://pubmed.ncbi.nlm.nih.gov/32766477/   This is the human alcohol-related liver disease research Brenner discusses when explaining disturbed liver NAD metabolism.   Nicotinamide for Skin-Cancer Chemoprevention — Andrew C. Chen et al. https://pubmed.ncbi.nlm.nih.gov/26488693/   This is the major Australian study relevant to Brenner's discussion of oral nicotinamide and skin cancer protection.   Charles Brenner on NAD+, NR vs. NMN & NAD IVs — Dr. Rhonda Patrick / FoundMyFitness https://www.foundmyfitness.com/episodes/charles-brenner   Dr. Mike specifically references Brenner's appearance with Rhonda Patrick during the episode.   Show Notes 00:00 Welcome to the Hart2Heart Podcast 00:58 NAD Basics Explained 02:22 Cellular Role of NAD 03:21 Proven Benefits and Trials 05:24 Inflammation Markers Deep Dive 09:19 Athletes Recovery and VO2 Max 13:52 Does NAD Decline With Age 20:10 Skin NAD and UV Damage 23:40 Who Should Take NR 27:56 Niacin vs NR vs NMN 32:28 NMN Conversion and Quality 35:37 IV and Injection Warnings 42:18 Dosing Timing and Alcohol 46:50 Addiction Claims and Dream Trials 51:39 Parkinsons and Long COVID Data 55:03 Sinclair Critique Revisited 57:05 Stacking Supplements and Metformin 59:58 Wrap Up and Where to Follow   The Hart2Heart podcast is hosted by family physician Dr. Michael Hart, who is dedicated to cutting through the noise and uncovering the most effective strategies for optimizing health, longevity, and peak performance. This podcast dives deep into evidence-based approaches to hormone balance, peptides, sleep optimization, nutrition, psychedelics, supplements, exercise protocols, leveraging sunlight, and de-prescribing pharmaceuticals — using medications only when absolutely necessary. Beyond health science, we explore the intersection of public health and politics, exposing how policy decisions shape our health landscape and what actionable steps people can take to reclaim control over their well-being. Guests range from out-of-the-box thinking physicians such as Dr. Casey Means (author of "Good Energy") and Dr. Roger Sehult (Medcram lectures) to public health experts such as Dr. Jay Bhattacharya (Director of the National Institutes of Health (NIH) and Dr. Marty Mckary  (Commissioner of the Food and Drug Administration (FDA) and high-profile names such as  Zuby and Mark Sisson (Primal Blueprint and Primal Kitchen). If you're ready to take control of your health and performance, this podcast is for you.We cut through the jargon and deliver practical, no-BS advice that you can implement in your daily life, empowering you to make positive changes for your well-being.   Connect with Dr. Mike Hart Instagram: @drmikehart Twitter: @drmikehart Facebook: @drmikehart

This episode explores the opportunities and risks of testosterone optimization, beginning with the US military's decision to screen men over 30 for low testosterone. Dr. Mike Hart and Dr. Jonathan Schoeff discuss why symptoms such as fatigue, low libido, and difficulty changing body composition cannot be interpreted from a single lab value. They examine the importance of free testosterone, SHBG, insulin resistance, visceral fat, estradiol, DHT, fertility, and individualized dosing. The conversation also challenges common measures such as BMI and body fat percentage, emphasizing skeletal muscle mass, visceral adiposity, sustainable health goals, and the minimum effective intervention.   Dr. Jonathan Schoeff is a spinal surgeon and longevity medicine practitioner whose work focuses on hormone health, metabolic optimization, body composition, and individualized health strategy. Through comprehensive laboratory testing, clinical assessment, and personalized treatment planning, he helps clients understand how hormones, insulin sensitivity, muscle mass, visceral fat, lifestyle, and long-term health goals interact. Describing his role as that of a "biological strategist," Dr. Schoeff emphasizes precision over standardized protocols and develops practical plans designed around each person's biology, priorities, and daily life.   Health and Human Performance Optimization to Enhance Military Readiness — U.S. Department of War https://media.defense.gov/2026/Jul/15/2003961654/-1/-1/1/HEALTH%20AND%20HUMAN%20PERFORMANCE%20OPTIMIZATION%20TO%20ENHANCE%20MILITARY%20READINESS%20OSD004430-26%20RES%20FINAL.PDF   Influence of CAG Repeat Polymorphism on the Targets of Testosterone Action — Giacomo Tirabassi et al. https://pubmed.ncbi.nlm.nih.gov/26421011/   Comparative Effects of Daily and Weekly Boron Supplementation on Plasma Steroid Hormones and Proinflammatory Cytokines — Mohammad Reza Naghii et al. https://pubmed.ncbi.nlm.nih.gov/21129941/   Women's Health Initiative — National Heart, Lung, and Blood Institute, National Institutes of Health https://www.nhlbi.nih.gov/science/womens-health-initiative-whi   Surviving Sepsis Campaign Adult Guidelines — Society of Critical Care Medicine https://www.sccm.org/survivingsepsiscampaign/guidelines-and-resources/surviving-sepsis-campaign-adult-guidelines   The Longevity Lab — Dr. Jonathan Schoeff and Candace Schoeff https://longevitylabwellness.com/   Jonathan Schoeff on Instagram — Dr. Jonathan Schoeff https://www.instagram.com/jonschoeff/   Jonathan Schoeff on YouTube — Dr. Jonathan Schoeff https://www.youtube.com/@drjonschoeff   Show Notes   00:00 Welcome to the Hart2Heart Podcast 00:42 Military Low T Screening 04:32 Normal Ranges and Treatment 08:19 Free Testosterone and Insulin 12:35 High SHBG and Enclomiphene 15:54 hCG Fertility and Protocols 19:35 Obesity Low T Strategy 23:26 Aromatase Inhibitors and Estrogen 26:51 DHT Mood and Libido Balance 28:57 DHT Balance Risks 30:10 Minimum Effective Dose 31:55 Longevity Strategy Mindset 33:31 Clinic Cuts Alcohol Use 35:40 Goals Drive Strategy 38:06 Body Fat Targets Debate 41:54 Sustainable Leanness 45:33 Personalized Nutrition Plans 48:09 Beyond Body Fat Metrics 52:29 Rules Not Regulations 53:31 Wrap Up And Where To Find   The Hart2Heart podcast is hosted by family physician Dr. Michael Hart, who is dedicated to cutting through the noise and uncovering the most effective strategies for optimizing health, longevity, and peak performance. This podcast dives deep into evidence-based approaches to hormone balance, peptides, sleep optimization, nutrition, psychedelics, supplements, exercise protocols, leveraging sunlight, and de-prescribing pharmaceuticals — using medications only when absolutely necessary. Beyond health science, we explore the intersection of public health and politics, exposing how policy decisions shape our health landscape and what actionable steps people can take to reclaim control over their well-being. Guests range from out-of-the-box thinking physicians such as Dr. Casey Means (author of "Good Energy") and Dr. Roger Sehult (Medcram lectures) to public health experts such as Dr. Jay Bhattacharya (Director of the National Institutes of Health (NIH) and Dr. Marty Mckary  (Commissioner of the Food and Drug Administration (FDA) and high-profile names such as  Zuby and Mark Sisson (Primal Blueprint and Primal Kitchen). If you're ready to take control of your health and performance, this podcast is for you.We cut through the jargon and deliver practical, no-BS advice that you can implement in your daily life, empowering you to make positive changes for your well-being.   Connect with Dr. Mike Hart Instagram: @drmikehart Twitter: @drmikehart Facebook: @drmikehart

Dr. Kyle Gillett joins Dr. Mike Hart to discuss safer, more practical approaches to biohacking, performance, and longevity. They cover indoor microplastic exposure, bromantane, low-dose nicotine, healing peptides, BPC-157 safety, tesamorelin, growth hormone, GLP-1 digestive side effects, NAD support, carnitine, hair loss, sleep medications, and longevity treatments. Dr. Gillett separates promising interventions from overhyped protocols while emphasizing evidence, appropriate dosing, consistency, and individual risk. Dr. Kyle Gillett is a physician and founder of Gillett Health whose work focuses on personalized hormone care, metabolic health, performance, and longevity. He uses laboratory results, symptoms, medical history, lifestyle, and treatment response to guide decisions about hormones, medications, peptides, and supplements. He also hosts the Gillett Health Podcast and founded Sage Bio.   [Gillett Health] — Dr. Kyle Gillett and James O'Hara https://gilletthealth.com/ [The Gillett Health Podcast] — Dr. Kyle Gillett and James O'Hara https://podcasts.apple.com/us/podcast/the-gillett-health-podcast/id1631735999 [Sage Bio Laboratory Testing] — Sage Bio, Inc. https://www.sagebio.com/ [AirDoctor Air Purifiers] — AirDoctor and Ideal Living https://airdoctorpro.com/ [Consensus Research Search] — Consensus https://consensus.app/ [Google Scholar] — Google https://scholar.google.com/ [Cravv Cytisine Product Information] — Health Canada https://health-products.canada.ca/lnhpd-bdpsnh/info?licence=80072525 [Juven Therapeutic Nutrition] — Abbott Nutrition https://www.abbottnutrition.com/our-products/juven [EGRIFTA WR Tesamorelin Prescribing Information] — U.S. Food and Drug Administration https://www.accessdata.fda.gov/drugsatfda_docs/label/2025/022505s020lbl.pdf [QUVIVIQ Daridorexant Information] — Idorsia Pharmaceuticals https://www.quviviq.com/ [DAYVIGO Lemborexant Information] — Eisai https://www.dayvigo.com/ [Micro- and Nanoplastics in Coronary Circulation Study] — Pasquale Paolisso and colleagues, European Heart Journal https://academic.oup.com/eurheartj/advance-article/doi/10.1093/eurheartj/ehag447/8725569 [CJC-1295 FDA Review Materials] — U.S. Food and Drug Administration, Pharmacy Compounding Advisory Committee https://www.fda.gov/advisory-committees/advisory-committee-calendar/updated-meeting-time-and-public-participation-information-december-4-2024-meeting-pharmacy [Kyle Gillett, MD on Instagram] — Dr. Kyle Gillett https://www.instagram.com/kylegillettmd/   Show Notes 00:00 Welcome to the Hart2Heart Podcast 00:45 Bromantane Overview 02:16 How Bromantane Works 04:45 Trump Debate Stack 06:03 Nicotine Microdosing 08:39 Cartilax vs BPC 12:06 Ultimate Healing Stack 14:09 Healing Supplements 16:26 Tesamorelin Benefits 21:09 Growth Hormone Dosing 22:54 Kids and Height 25:13 Selank and Benzo Taper 28:59 Best Time for BPC 31:03 BPC Safety Risks 33:00 GLP1 Motility Fixes 34:39 Low Dose Naltrexone Uses 36:06 LDN and Alcohol Effects 37:10 GLP-1 Heartburn Fixes 38:42 GLP-1s and Drinking 40:18 Hangover Supplement Stack 42:55 Oral vs Injectable Carnitine 45:27 NAD+ Shots vs Precursors 47:35 Hair Loss Stack for Men 50:44 Topical Dutasteride Strategy 56:06 Hair Loss Stack for Women 56:59 Top Longevity Meds 01:00:28 Aspirin Nuance and Lp 01:02:25 TUDCA for Gallbladder 01:04:36 Leptin Resistance Basics 01:06:33 Microplastics and Indoor Air 01:10:03 Wrap Up and Where to Find   The Hart2Heart podcast is hosted by family physician Dr. Michael Hart, who is dedicated to cutting through the noise and uncovering the most effective strategies for optimizing health, longevity, and peak performance. This podcast dives deep into evidence-based approaches to hormone balance, peptides, sleep optimization, nutrition, psychedelics, supplements, exercise protocols, leveraging sunlight, and de-prescribing pharmaceuticals — using medications only when absolutely necessary. Beyond health science, we explore the intersection of public health and politics, exposing how policy decisions shape our health landscape and what actionable steps people can take to reclaim control over their well-being. Guests range from out-of-the-box thinking physicians such as Dr. Casey Means (author of "Good Energy") and Dr. Roger Sehult (Medcram lectures) to public health experts such as Dr. Jay Bhattacharya (Director of the National Institutes of Health (NIH) and Dr. Marty Mckary  (Commissioner of the Food and Drug Administration (FDA) and high-profile names such as  Zuby and Mark Sisson (Primal Blueprint and Primal Kitchen). If you're ready to take control of your health and performance, this podcast is for you.We cut through the jargon and deliver practical, no-BS advice that you can implement in your daily life, empowering you to make positive changes for your well-being.   Connect with Dr. Mike Hart Instagram: @drmikehart Twitter: @drmikehart Facebook: @drmikehart

Dr. Mike Hart welcomes Ksenia Petrushkina back for a wide-ranging conversation about using hormones, GLP-1 medications, and peptides more thoughtfully. They explore why lower, individualized doses of tirzepatide may improve tolerability, which blood markers should be monitored during treatment, and how progesterone may support sleep through its effects on GABA. They also discuss women's hormone replacement therapy, personalized testosterone dosing, TRT and fertility, thyroid treatment, low-dose naltrexone, and the difference between evidence-based peptide use and exaggerated online claims. Ksenia Petrushkina is a clinician whose work focuses on hormone optimization, peptide therapy, metabolic health, and highly individualized treatment. Through comprehensive blood testing, symptom assessment, careful dose adjustments, and ongoing patient monitoring, she helps men and women better understand how hormones, medications, and peptides may affect their energy, sleep, inflammation, fertility, body composition, and long-term health. Her approach challenges standardized protocols and social-media biohacking trends, emphasizing personalized medicine, responsible prescribing, and evaluating one intervention at a time.   Quick Coherence Technique — HeartMath https://help.heartmath.com/introduction/quick-coherence-technique/ The Levels of Ghrelin, Glucagon, Visfatin and GLP-1 Are Decreased in the Peritoneal Fluid of Women with Endometriosis — Aleksey M. Krasnyi et al. https://pubmed.ncbi.nlm.nih.gov/36142272/ Women's Health Initiative — National Heart, Lung, and Blood Institute, National Institutes of Health https://www.nhlbi.nih.gov/science/womens-health-initiative-whi Facial Beauty Age Support Serum for Estrogen Deficiency — Quicksilver Scientific https://www.quicksilverscientific.com/products/facial-beauty-serum Peptides: The Science, Uses & Safety — Dr. Andrew Huberman and Dr. Abud Bakri https://www.hubermanlab.com/episode/peptides-the-science-uses-and-safety-abud-bakri Vladimir Khavinson Publications — Professor Vladimir Khavinson https://khavinson.info/publications   Show Notes   00:00 Welcome to the Hart2Heart Podcast 00:57 GLP-1 Starting Doses 03:39 GLP-1 Anti Inflammation Aging 07:15 Motility Supplements Side Effects 09:02 Tirzepatide vs Semaglutide 11:46 Adrenal Fatigue Myth 13:23 Fatigue Bloodwork Checklist 16:16 TRT Hematocrit Sleep Apnea 19:01 Underrated Blood Tests 20:06 Womens HRT Basics 22:21 Testosterone for Women 25:19 Thyroid Treatment LDN NAD 29:31 Progesterone GABA Sleep 32:25 Progesterone for Men Debate 33:43 Testosterone Injection Frequency 36:05 TRT Dosing Frequency 36:45 Why TRT Stops Working 37:50 Creams vs Injections 39:08 Fertility and HCG 41:46 Peptides vs Pharma 44:17 HGH and Secretagogues 45:12 5-Amino-1-MQ Hype 48:15 Topical GHK-Cu Skincare 50:25 Injectable Copper Peptide Hair 52:26 BPC 157 and TB500 58:25 Thymosin Alpha 1 Immunity 01:01:13 Mitochondrial Peptides 01:03:20 Endo 205 and New Peptides 01:04:17 Kavinson and Epitalon 01:08:21 Wrap Up and Where to Find   The Hart2Heart podcast is hosted by family physician Dr. Michael Hart, who is dedicated to cutting through the noise and uncovering the most effective strategies for optimizing health, longevity, and peak performance. This podcast dives deep into evidence-based approaches to hormone balance, peptides, sleep optimization, nutrition, psychedelics, supplements, exercise protocols, leveraging sunlight, and de-prescribing pharmaceuticals — using medications only when absolutely necessary. Beyond health science, we explore the intersection of public health and politics, exposing how policy decisions shape our health landscape and what actionable steps people can take to reclaim control over their well-being. Guests range from out-of-the-box thinking physicians such as Dr. Casey Means (author of "Good Energy") and Dr. Roger Sehult (Medcram lectures) to public health experts such as Dr. Jay Bhattacharya (Director of the National Institutes of Health (NIH) and Dr. Marty Mckary  (Commissioner of the Food and Drug Administration (FDA) and high-profile names such as  Zuby and Mark Sisson (Primal Blueprint and Primal Kitchen). If you're ready to take control of your health and performance, this podcast is for you.We cut through the jargon and deliver practical, no-BS advice that you can implement in your daily life, empowering you to make positive changes for your well-being.   Connect with Dr. Mike Hart Instagram: @drmikehart Twitter: @drmikehart Facebook: @drmikehart

Dr. Tyler Panzner joins Dr. Mike Hart to explain how genetics, supplement combinations, and individual brain chemistry can influence anxiety, irritability, brain fog, and the persistent "monkey on your back" feeling. They examine why the MTHFR gene is scientifically valid but often overmarketed, and why methylated B vitamins, SAMe, creatine, phosphatidylcholine, and other methylation-related supplements may help some people while overstimulating others. The conversation also explores hidden "adrenaline trappers" such as quercetin, polyphenols, and greens powders; why NAC, glutathione, and high-dose antioxidants may cause unwanted effects; and how lithium orotate, melatonin, nicotine, methylene blue, omega-3s, collagen, mitochondrial enhancers, and DHT-lowering supplements can affect people differently. Dr. Panzner also discusses pharmacogenomics, SSRI response, supplement timing around exercise, the limitations of genetic testing, and the importance of combining DNA data with bloodwork, symptoms, medication history, and baseline nutrient status. Dr. Tyler Panzner is a pharmacology and genetics expert whose work focuses on personalized supplementation, genetic testing, neurotransmitter pathways, and understanding why the same health intervention can affect people very differently. Through DNA analysis, laboratory review, supplement audits, and individualized coaching, he helps clients identify which biological pathways may need support and which commonly recommended supplements may be working against them. His approach challenges one-size-fits-all biohacking and emphasizes using genetics, bloodwork, symptoms, and personal response patterns to make more informed decisions about mental health, performance, and long-term wellness.   Work with Dr. Tyler Panzner! Unlock Your Genetic Potential — Dr. Tyler Panzner https://drtylerpanzner.com/ Dr. Tyler Panzner on Instagram — Tyler Panzner https://www.instagram.com/drtylerpanzner/ Quieting an Overactive Mind Webinar — Tyler Panzner https://overstimulated.drtylerpanzner.com/webinar-registration-page   Show Notes 00:00 Welcome to the Hart2Heart Podcast 00:47 MTHFR Hype vs Reality 02:14 Methylated Bs and Anxiety 03:48 Creatine Choline and SAMe 07:43 Beyond One Gene Test 11:14 Lithium Orotate Basics 15:18 Supplements That Backfire 17:36 Antioxidant Overload Effects 21:01 Melatonin Dose Debate 23:56 Antioxidants Around Workouts 26:48 Collagen What Actually Works 30:07 SSRIs and Genetic Fit 34:23 Herbal SSRI Alternatives 37:18 DHT Lowering Side Effects 41:54 Biohacking Marketing Hype 43:25 Fish Oil Mood Ratios 46:16 Oral Nicotine Tradeoffs 52:03 Methylene Blue Risks 54:46 Mitochondria Boosters Anxiety 57:13 Greens Powders Overstimulation 01:01:04 Magnesium Forms For Sleep 01:04:51 DNA Testing And ChatGPT 01:12:23 Genetics For Caffeine Sensitivity 01:16:23 Psychedelics And DNA 01:18:50 Coaching Logistics Wrap Up   The Hart2Heart podcast is hosted by family physician Dr. Michael Hart, who is dedicated to cutting through the noise and uncovering the most effective strategies for optimizing health, longevity, and peak performance. This podcast dives deep into evidence-based approaches to hormone balance, peptides, sleep optimization, nutrition, psychedelics, supplements, exercise protocols, leveraging sunlight, and de-prescribing pharmaceuticals — using medications only when absolutely necessary. Beyond health science, we explore the intersection of public health and politics, exposing how policy decisions shape our health landscape and what actionable steps people can take to reclaim control over their well-being. Guests range from out-of-the-box thinking physicians such as Dr. Casey Means (author of "Good Energy") and Dr. Roger Sehult (Medcram lectures) to public health experts such as Dr. Jay Bhattacharya (Director of the National Institutes of Health (NIH) and Dr. Marty Mckary  (Commissioner of the Food and Drug Administration (FDA) and high-profile names such as  Zuby and Mark Sisson (Primal Blueprint and Primal Kitchen). If you're ready to take control of your health and performance, this podcast is for you.We cut through the jargon and deliver practical, no-BS advice that you can implement in your daily life, empowering you to make positive changes for your well-being. Connect with Dr. Mike Hart Instagram: @drmikehart Twitter: @drmikehart Facebook: @drmikehart