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This post is a high-level brain-dump of my current best models of the core pathways of aging, as I currently understand them. I have no particular reason to avoid calling out claims I think are wrong/irrelevant, and I’m going to present high-level models without pages and pages of disclaimers and discussions about results which maybe disagree with them (but are probably just wrong/irrelevant).

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Core pathways of aging

2021/06/10

Most overviews of aging suffer from multiple problems: They dump a bunch of findings with no high-level picture. Many of the claims they make are outdated, purely theoretical, and sometimes even outright disproven by existing work. They are usually written by working academics, who are shy about telling us when their peers’ work is completely wrong. They are shy about making strong claims, since this would also implicitly mean denying some claims of the authors’ peers.