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When an AI tool cannot complete a critical safety-reporting task, should a healthcare leader buy a more powerful model—or rethink the problem? A pharmacovigilance team needs to reconcile safety reports and extract patient-level data from PDFs under a tight deadline. Its AI tool cannot handle the most time-consuming step. That real-world challenge opens a candid discussion about what it takes to make AI useful in healthcare. In this Alloutcoach episode, Tim Mikhelashvili, PharmD, Founder and CEO of Amedea Pharma and Founder and Host of the Medical Innovation Olympics, brings together experts in AI, regulatory strategy, scientific affairs, and life sciences consulting. Recorded at the fifth annual Medical Innovation Olympics Finals and Closing Ceremony at Rockefeller Center in New York on October 16, 2026, the panel examines three connected questions: How should leaders implement AI? How can scientific teams contribute their full expertise? And how can these technologies help improve patient outcomes? The experts challenge the pressure to adopt the newest model, explain why traditional machine learning still matters, and discuss how organizations can evaluate tools as technology evolves. They also explore citizen developer programs, personalized melanoma treatment, and the trust needed among patients, caregivers, and manufacturers. As Neil Banerjee puts it: “Do not believe in the hype or the fear.” Listen for practical perspectives on:• Defining AI’s context of use before deployment• Deciding when human oversight is necessary• Monitoring model drift and data drift• Bringing scientists into AI development• Connecting innovation with meaningful patient benefit EXPERT PANELTala Fakhouri, PhD, MPH — Chief AI and Regulatory Strategy Officer, Parexel; former FDA Director of AI PolicySourav (Neil) Banerjee — Founder and CEO, QMSintegrityJoão Dias — Head of Global Scientific Affairs, HaemoneticsVenera Jordan — Founder and Principal, DigitalProductGuru With audience questions from Graham Long and Alex Palumbo. Original session: Redefining the Role of AI on Leadership, Talent, and Impact on Healthcare. CHAPTERS00:00:00 Opening00:00:57 Panel Highlights00:05:37 Responsible AI Leadership00:06:34 Meet the Expert Panel00:08:45 Safety Reporting Case Study00:10:00 Defining Context of Use00:12:43 Human Control and Autonomous AI00:14:35 Does Every Project Need Agentic AI?00:16:58 Multimodal AI and Drug Discovery00:19:59 Choosing Models as AI Evolves00:24:24 Keeping Models Current00:26:32 Workforce Readiness00:27:17 Citizen Developers00:29:05 Why AI Needs Scientists00:29:48 Improving Patient Outcomes00:30:53 Personalized Melanoma Treatment00:33:04 Building Trust in Healthcare AI Explore Amedea Pharma and the ANCORA Decision Assistant:https://amedeapharma.com/solutions Discover the Medical Innovation Olympics:https://medicalinnovationolympics.com Follow Alloutcoach for conversations with healthcare innovators, scientists, and leaders.

All healthcare organizations are looking for more productivity, higher performance, and collaboration in a time when it is difficult to align teams around purpose. This live expert panel from the 2026 Medical Innovation Olympics at the Rockefeller Center challenges modern healthcare executives to take an inside look and change how they define performance and ROI. Featured Speakers:1) Christ Cook, a double-Olympian, global performance coach and consultant at the NHS UK, Microsoft and other organizations, , as well as investors, and life science executives:2) Christopher Piedmonte, Managing Partner, Neoterra Capital3) Charles Legg, Chief Operating Officer, CureLab Oncology, and 4) Graham Long, Chief Commercial Officer, Amedea Pharma, and5) Tim Mikhelashvili, CEO, Amedea Pharma, Founder & Host, #and MIO2026 The discussion takes the common goals of productivity and performance from aspirations into predictable reality and daily excellence with 3 case studies demonstrating the business value of internal competition combined with transparency, and a centralized performance analytics software solution that is designed for a new generation of healthcare champions. These champions give their best because the ANCORA Decision Assistant solution highlighted by the panel challenges them, makes their daily work count, and rewards them for their progress and small wins across their long journey to patient outcomes. The ultimate question the panel poses to the speakers and the audience is the following: How should modern healthcare leaders define and communicate their team performance differently in 2026-2027 and beyond?Set up a meeting with Tim Mikhelashvili at Amedea Pharma https://calendly.com/amedeapharma to drive continuous growth of your impact in a predictable manner by generating real views that drive real results (Tim's email: [email protected]).00:00 Highlight00:45 #MO2026 Intro Music01:37 Preview of Discussion Format02:52 Speaker Introductions05:20 Chris Cook: Champions Don't Wait for Outcomes, They Measure09:12 Visibility Problem: Pharma has no idea what drives Outcomes12:03 Why Leaders Must Redefine Performance to grow12:30 Gore & Associates: KPIs & performance - 68 yrs of profit/growth13:46 Centralized Master Performance Database scales a Launch16:11 Big Pharma Measures both Performance and Behaviors to Grow17:26 Amedeas ANCORA Platform - Purpose, Progress and Reward18:04 ANCORA makes daily work visible and traceable to Outcomes19:10 Jamie Dimon, JP Morgan: CEOs should work like Olympic teams19:33 Q&A - How should health leaders redefine performance today?19:54 Communication to stimulate emotions and stimulate shared purpose21:20 Leaders have the data, they lack implementation22:20 Charles Legg story: why the "Behind the Scenes" of Outcomes Matters25:02 Make data more shareable, give authority not just responsibility27:41 As teams become larger, replicate best communication

On October 16, 2026 the 5th annual Medical Innovation Olympics brought some of the brightest healthcare leaders in the world together at 1 Rockefeller Plaza in New York, NY for the emotional and unforgettable Final and Closing Ceremony.Tim Mikhelashvili, CEO, Amedea Pharma, Founder and Host of #MIO2026 and Shota Bagaturia, CEO, NewsOut!, co-host, welcomed the international community gathered in person and virtually.Watch the full opening session because it describes why this particular format of competition and healthcare event is especially critical today. During a time in which humans are increasingly told they are actually not that smart, that everything they love to do will soon be done by technology, we provide an Olympic forum every year for Medical Innovators to celebrate their ambition, potential, talents, character, and achievement. The message came with a challenge to make sure that however we innovate, we honor the wisdom of the generations that came before us and ensure that humans continue to grow and thrive for generations ahead. CHAPTERS00:00 Olympic Musical Intro00:57 Magic of Mixing Olympians, Scientists, Investors, Startups02:07 Guest speaker and Agenda Preview03:53 Why this event places Humans in Front04:29 Power of the Human Brain vs AI 05:08 Revisiting the Renaissance to Accelerate Innovation06:45 This year's theme - "Crystal Clear, Treatment Near"07:41 Join a Race for Purpose - Grow Human Capability and Connection08:46 Ultimate Challenge - Continuity of Human Life and Growth09:22 Recognitions to the Board, Competitors, Judges, Sponsors11:36 Shota Bagaturia's host welcome

How do we move healthcare innovation from promise to proof? Tim Mikhelashvili, PharmD, CEO of Amedea Pharma and founder and host of the Medical Innovation Olympics, moderates this Alloutcoach Podcast expert panel from the 2026 ribbon-cutting ceremony and Trials Session 1 at Rockefeller Center, New York City. “From Promise to Proof in AI Tech and Health Systems” features Gregg Jackson, Charles Legg, Tina Rezakhani, and Srinivasan Krishnan, bringing perspectives from medtech, biotech, medical affairs, patient experience, and technology innovation. Why do healthcare AI pilots struggle to scale? Who should make investment decisions? What clinical evidence, reimbursement strategy, and ROI do investors need? The panel explores global clinical trials, biosimilars, patient advocacy, reliable health information, wearables, longevity, and the shift toward preventive care. Audience Q&A covers AI costs, early-stage fundraising, accelerators, and the measurable value of integrative care. CHAPTERS 00:00 Ribbon-cutting and panel highlights 03:50 From Promise to Proof: panel introduction 05:04 Meet the healthcare and biotech experts 11:12 Why do healthcare AI pilots fail to scale? 15:10 Who should make AI investment decisions? 18:32 What evidence do biotech investors need? 25:13 How does global competition benefit patients? 33:08 How can we accelerate biosimilar access? 34:30 How can patients get reliable health information? 37:06 How can wearables support preventive care? 39:42 Will pharma shift toward longevity and prevention? 42:22 Which healthcare innovations hold the most promise? 49:34 What evidence shows innovation is delivering value? 51:53 Audience Q&A: managing healthcare AI costs 54:05 Audience Q&A: how can early startups raise funding? 57:42 Audience discussion: measuring integrative care outcomes 01:00:17 Closing remarks and ribbon-cutting reprise Learn more and register for the 1-day virtual pass to attend the 5th annual Medical Innovation Olympics Finals and Closing Ceremony or sign up for the 1-year access to our international community of Healthcare Champions: https://medicalinnovationolympics.comFollow Alloutcoach Podcast for more healthcare innovation and leadership conversations. #MIO2026 #HealthcareAI #MedicalInnovation

What can healthcare innovators learn from an Olympian? In the opening keynote of the 5th Annual Medical Innovation Olympics #MIO2026 at Rockefeller Center in NYC, two-time Olympian swimmer and NHS UK Advisor Chris Cook shares lessons from elite performance and why they matter for leaders transforming healthcare. From missing a major competition by four-hundredths of a second to becoming a champion, Chris explores resilience, accountability, consistency, courage, teamwork, and incremental improvement - connecting world-class performance to turning ambitious healthcare ideas into measurable patient impact. The conversation concludes with a Q&A on failure, motivation, finding your “North Star,” and why the real gold is not the medal, but who you become in pursuit of something bigger than yourself. CHAPTERS 00:00 - The Mindset of People Who Change Industries Transformative leaders stay uncomfortable longer than everyone else. 00:25 - Welcome to the 5th Annual Medical Innovation Olympics Tim Mikhelashvili opens MIO 2026 with its mission: lasting impact on healthcare, society, and patients. 01:44 — Introducing Two-Time Olympian Chris Cook Chris describes MIO as fundamentally different from a traditional conference: “a competition with purpose.” 03:26 — What Olympic Performance Can Teach Healthcare Innovators Chris' Olympic journey, elite performance lessons, and innovators’ larger responsibility. 03:51 — The Work Nobody Sees Behind High Performance 4:30 a.m. starts, sacrifice, injury, doubt, repetition, and discipline reveal how excellence is built through consistent small decisions. 05:19 — Losing by 0.04 Seconds—and the Power of “Yet” After missing a major competition by four-hundredths of a second, Chris hears: you’re not good enough yet. Four years later, everything changes. 06:30 — From Setback to Champion Chris returns to win two gold medals and a silver—and explains how competitors think and respond differently. 07:05 — Innovators See Possibility Before There Is Proof Olympians and innovators pursue possibility while others demand proof—and stay uncomfortable long enough to create change. 07:42 — Measurement, Accountability & Healthcare Impact Measurement creates clarity. AI, data science, and precision medicine are powerful, but transformation also requires leadership and accountability. 09:21 — When Innovation Becomes Human Access, quality, and continuity of care are not abstract metrics—they affect patients, families, treatment, and time. 09:46 — Three Lessons from an Olympian Pressure is a privilege. Consistency beats intensity. Great teams outperform great individuals. 10:57 — Courage, Competition & Stepping Into the Arena Innovation requires vulnerability, evaluation, courage, and a willingness to participate rather than stay comfortable. 11:36 — Tiny Improvements Can Change Lives at Scale Better workflows, faster diagnoses, improved pathways, and breakthrough ideas compound into human impact. 12:41 — Q&A: The Healthcare Champions Nobody Sees Unrecognized professionals across safety, pharmacovigilance, product quality. 14:25 — “The Real Gold Is the Person You Become” The greatest reward is not the medal - it is who you become while pursuing something bigger than yourself. 15:57 — What Do You Do When Nothing Is Working? Q&A: How do you keep moving when experiments fail, progress stalls, and motivation disappears? 16:26 — Experiments Don’t Fail - They Produce Results Chris reframes failure: what matters is what you learn from results and what you do next. 16:56 — Inspiration, Motivation & Finding Your North Star Chris distinguishes enduring inspiration from motivation, which naturally rises and falls. 18:24 — Look Back to See How Far You’ve Come Focusing only on the gap ahead can demotivate us. Confidence also comes from recognizing how far we have traveled. 19:38 — Transformative Power of Sport Former IOC President Thomas Bach closes by reflecting on sport as a force for good and a tool for improving lives.

On April 30, we celebrated the kickoff of the 5th annual, global Medical Innovation Olympics (register today at https://medicalinnovationolympics.com) with a moving interview in which a 5-Time Olympic Gold Medalist swimmer, Type 1 Diabetes patient advocate and CEO, Anchor Line Sprots, Gary Hall Jr openly shared the devastation he went through losing all his Olympic models, his house and business in the Los Angeles Fires in 2025. He describes how the "fire left some piece of it in his belly" to pursue what he calls a new do-or-die mission for Olympic-adjacent sports to grow their fan engagement, funding, and popularity. In this conversation Gary demonstrates why he is a true leader of the people who fights daily for a bigger purpose, who cares deeply for the plight of the human community, patients. He shares deep reflections that scratch far beneath the surface with a call to action for innovators in tech and healthcare who have sacrificed their own jobs to be rewarded appropriately and aligned with the priorities they deserve in their respective industries - something all of us need to think about and address. Timeline 0:00 Episode Introduction 1:57 Medicalinnovaitonolympics.com - Sign up for the event 2:36 Meaning of 10 replacement medals Gary lost in the LA fires in '25 5:14 The Real-World Story of the LA Fire Disaster and Devastation 6:36 How the IOC presented the replica medals - 2nd time in history after Muhammad Ali 7:14 Last time the International Olympic Committee replaced a medal was Muhammad Ali 10:10 How Gary as T1Diabetes Patient defines Healthcare ChampionsGary Hall: Medical Innovation Olympics is a Noble Pursuit 11:21 Coders like Researchers have built AI that can replace them - Tremendous Sacrifice 11:54 How do we realign incentives so that people are rewarded on their sacrifice 12:26 Update on the latest research in T1Diabetes - we are on the doorstep 14:04 CEO of iTolerance's recent passing & promise of curing T1D without immunosuppression 14:53 Gary's opinion on Lindsay Vonn's comeback attempt and fall at Milano Cortina 17:06 Milano 2026 Olympic Highlight Alyssa Liu, Figure Skater's Charisma and Embodiment of Joy 18:11 Men's Hockey - U.S.A. 18:30 Sara Conti, Italian Figure Skating's visible 21:35 Gary Hall's new company, Anchor Line SportsOlympic adjacent sports betting fan engagement tool Olympic sports remain underfunded 23:30 U.S. is one of few countries where not one single dollar supports Olympic athletes 24:19 Anchor Line Sports is the silver lining Gary took away from losing his house, business, medals 27:57 Q & A: Parallels between building championship teams and healthcare companiesThe team is most important and the reflection of the leadership - pushing you to the point of failure every single day in a tough, and are able to do it in a tough, demanding and respectful way. This is exactly what great leaders do in the workplace. They lead by example, and they earn their respect. All ships rise with the tide. 30:09 Q & A: Support Gary Hall & Upcoming Announcement from Anchor Line Sports 31:14 Public Promise to Gary Hall Jr and Bob Beamon, former world record holder for Medical Innovation Olympics to Leave a Global Legacy 32:32 Gary's Endorsement and Best Wishes for the Growth of Medical Innovation Olympics

Years ago, watching TV at home, I discovered a true modern age humanist and true ambassador, Francesco Trecci, political science and history graduate, author, historian and commercial director who challenged himself to connect two antique and proud cultures, Italy and Republic of Georgia, illuminate them with knowledge to connect them on a deeper level. Ever since, I can proudly say we have become friends due to a common passion and interest that is central to the multicultural, global business leadership mission of the Alloutcoach Podcast. Enjoy this episode, which is a deeply personal conversation between us in which we discuss Francesco's journey and essentially describe how far a person's patriotism, humanism, as well as curiosity can go in becoming a celebrated, respected and admired figure an entire country knows based on the three books Trecci has written and his own inspiration to learn about a new culture in such incredible depth. Get to know Francesco Trecci on Facebook and across social media channels. The podcast is in Italian, but is fully subtitled in English. As a bonus musical dedication to this podcast, you will also hear a song called "Born in Georgia" I had written and produced completely with a new arrangement years ago based on a worldly famous Italian patriotic song "L'Italiano" by Toto Cutugno. The production in the studio involved people from 6 different cultures - a testament to how modern age humanism, respect, and curiosity for not just one's own but other countries can build bridges between people, illuminate, and enrich them, which is ever so critical in today's world. Timeline 0:00 Speaker and Episode Introduction 3:30 What inspired you initially to learn about the Republic of Georgia? 4:40 Where does your curiosity come from? 6:39 How do you define a person to whom one culture or one passion is not enough to be happy? 7:52 What are some historic figures that transcended borders that influenced you? 10:36 Why studying a foreign country in depth does not reduce your patriotism 12:54 Personal Story - Returning to my native Georgia after 8 years and its personal impact 14:06 Value of Modern Humanism and Ambassador Connecting 2 Cultures 14:48 Francesco Trecci's Three Books in Italian about Georgia 16:47 Biggest Success and Lesson in Francesco's Journey Connecting with people in Georgia thanks to the books he has written 18:02 Greetings and announcement of a musical dedication 19:04 Song: "Born in Georgia" - new arrangement based on an Italian Patriotic Song in Georgian 22:37 Closing Remarks: How a patriotic song dedicated to 1 song connected people from 6 different cultures in the recording studio

The unprecedented rapid pace of AI and tech innovation has transformed healthcare and life science organizations. With many new answers however come lots of new questions about how to ensure continuous reinforcement of deep, hands-on knowledge of the science and detailed steps behind the art of diagnosis or steps in an experiment, and to enable the best talent in healthcare truly express itself despite the real-world struggles to find the resources they truly need and fill the job positions where their innovation can flourish. At the 2025 Medical Innovation Olympics, Tim Mikhelashvili (CEO, Amedea Pharma, Host #MIO2025) brought together an expert panel of executives in Human Resources, Life Sciences, Marketing, Founders and Investors (Kim Mack, Founder & Principal, HR Reinforced; Christina Smith, Founder, Neo HR Consulting Group; Christopher Piedmonte, Managing Director, NeoTerra Capital, and Bart Zoni, SVP Innovation & Product, Woven Health Collective) addressed a sensitive question on top of millions of people's minds in healthcare - in an AI-powered talent market, how do we hire, reward, and retain teams where deep scientific judgment and technical execution must win together—every single day? This session focused on the underlying human factors behind both layering and rewarding the best talent across science and tech in healthcare. Speakers shared practical solutions to build a strong culture that rewards both as leaders, hire, interview, onboard teams, as well as distinguish talent through innovative methods such as video submissions of candidates' CV's or work samples. 0:00 Episode Highlight 1 - Move from "No But to Yes If" in Medicine 0:49 Episode Highlight 2 - Fusion of Science & Tech 1:34 Opening Remarks - Lots of Talent - Few Ways to Express It 3:07 Expert Panelist Introductions 5:41 How do you reward Science versus Tech in Life Sciences? 10:11 Hiring True Talent in the Age of AI crafted Resumes 16:38 Onboarding & Retaining Best Talent 17:05 What the Tech Industry should learn from Science? 19:24 What Life Science should learn from Tech 20:17 Driving Quality Science despite more Informal Training 21:05 Building Cross-Functional Pods across Science & Tech 26:28 Q&A: How do you balance and upskill Medical Talent? 27:57 Q&A: How do you work around AI to hire best talent? 30:50 Q&A: Value of Video Submissions of CVs/Resumes 31:42 Q&A: Work Sample or Task Completions in Interviews 32:27 Final Thoughts - Optimism about Rewarding Best Talent

At the 2025 Medical Innovation Olympics, a powerful all-star expert panel moderated by Melissa Norcross (Vice President, Corporate Strategy, Hyland Software) featuring Eddie Power (CEO, Empower Medical, former Global Medical Affairs Leader at Pfizer), Vivek Mukhatyar (Senior Director, Medical AI Team Lead, Pfizer), and Ravi Kiran Koppichetti (Senior Analyst, Manufacturing Technology, Vertex; former Lead IT Data Engineer, Novo Nordisk) cut through the hype and delivered a practical playbook for leaders in healthcare: 1) Fall in love with the problem, not the tool; 2) Think in systems, not silos; and 3) Train your people, not just your models. Timeline 00:00 Highlight 1: Why AI Innovation Fails When the Problem Is Mis-framed 01:20 Highlight 2: Probable vs Precise Decisions: Where AI Helps vs Where Governance Must Lead 03:38 Highlight 3: Falling in Love with the Problem, Not the Solution 04:38 Highlight 4: Non-Patient AI Use Cases: Process, Partnership & Proof 06:00 Leadership in the Age of AI: Framing the Right Questions 08:52 Systems Thinking in Healthcare Innovation (Hepatitis C Case Study) 11:35 Constraints in Medical Affairs: Where Humans Must Stay in the Loop 13:19 AI as “Intelligence on Tap” vs Clinical Decision Authority 17:53 Defining Target Conditions and What “Done” Really Means 20:15 Systems Failures in Real-World Healthcare Environments 22:50 How Providers, Payers, and Pharma Are Using AI Today 25:47 Who Decides: Human vs AI Agents in Regulated Healthcare 27:18 Industry 4.0 Explained: Integrating OT and IT in Pharma Manufacturing 30:33 Data Quality, Trust, and Why Most Organizational Data Is Unstructured 32:03 Probabilistic AI vs Precision Decisions: A Leadership Framework 34:35 Trust, Evaluations, and Human-in-the-Loop AI Design 39:11 Why 95% of AI Pilots Fail — and the Role of AI Ambassadors 43:08 Closing Reflections: Systems Thinking, Learning Loops, and Fearless Curiosity

Advancing longevity research is about honoring the value of life—and translating that respect into evidence-based prevention. If healthcare is judged by life expectancy + quality of life, longevity medicine may be one of the most meaningful metrics we can pursue: extending health span through early detection, validated biomarkers, and interventions that scale. This unforgettable Expert Panel from the 4th annual Medical Innovation Olympics (#MIO2025) convened all-star global leaders in Longevity and Preventive Medicine who separated hype from reality and outlined what it will take to bring longevity into mainstream care - rigorously, ethically, and accessibly. Topics include: breakthroughs (including epigenetic approaches pointing toward functional restoration of eyesight), biomarkers/endpoints as the “keystone” for faster trials, the TAME (Targeting Aging with Metformin) concept, and the role of standards, education, trust, and shared responsibility—keeping dignity central. Panelists: Dr. David Barzilai (Harvard Medical School; Geneva College of Longevity Science, GCLS) • Dr. Dominik Thor (President, GCLS) • Dr. Mishkat Shehata (Emirates Lifestyle & Longevity Medicine Society) • Keith Comito (Lifespan Research Institute) • Dr. Uma Senthilkumar (Three Five Revive) 🔗 Amedea Pharma: www.amedeapharma.com 🏅 Medical Innovation Olympics: #MIO2025 🎧 Subscribe for more episodes on longevity, innovation, and performance in healthcare. #MIO2025 #LongevityMedicine #Healthspan #AgingResearch #PreventiveMedicine #AmedeaPharma #Alloutcoach 00:00:00 Highlight 1: Four takeaways: fund research, education, transparency and 00:01:16 Highlight 2: TAME trial explained: endpoints beyond one disease 00:02:05 Highlight 3: “Do something now”: Alzheimer’s screening + vocal diagnostics 00:02:43 Highlight 4: Multi-omics: organ ages, pace of aging, microbiome, proteomics 00:03:54 Highlight 5: Meaning of longevity: purpose, shared responsibility, dignity 00:04:41 Highlight 6: Present Longevity Medicine as an Economic Benefit 00:05:58 Host Welcome: Longevity as duty, continuity, 00:09:54 Which breakthroughs in longevity show biggest promise 00:11:15 Pharma signal: GLP-1s + industry entering “by proxy” to aging biology 00:12:44 Precision era: epigenetics + multi-omics become clinic-standard 00:14:19 Case study: epigenetic reprogramming restores vision in models 00:16:42 Breakthroughs needed in next 1–2 yrs for longevity to go mainstream 00:17:30 Composite biomarkers regulators & public can trust 00:19:14 Biomarkers → shorter trials + precision feedback loops 00:23:10 Regulatory fragmentation across countries 00:26:21 How do we fit longevity into health systems? 00:27:30 TAME trial: “aging as target” + diagnostics role in preventive care 00:30:36 Call to action: fund TAME + UAE leadership recognition 00:31:05 Steps you can take now: Alzheimer's vocal screening 00:36:05 Where can stakeholders intersect - take action anywhere they live? 00:37:00 How patients, biopharma, regulators, payers align on health span 00:39:12 Is the goal to live forever? Health span vs lifespan 00:39:49 Tithonus myth: why “health span” changes public acceptance 00:41:34 Lifespan vs health span—and “how about both?” 00:42:15 Q&A: How do we attract top talent into longevity research? 00:42:15 Economic + ethical case for talent/policymakers 00:44:37 Q&A: Categorizing aging as disease—impact on regulation/cost/access? 00:44:39 Most effective way to reduce suffering + economic burden; society-wide case 00:46:08 Longevity reflects dignity, vitality and purpose: “health span is a shared responsibility” 00:47:18 Mindset shift: passive consumers → active participants 00:47:46 Get involved: Lifespan + public engagement campaign 00:48:32 Education + trusted sources vs “abbreviated” biohacking info 00:49:30 Four calls to action: increase funding, training, evidence, & access 00:52:25 Closing

The 2025 Medical Innovation Olympics featured one of the most memorable and personal interviews with Amber Salzman, CEO at Epicrispr Biotechnologies, an extraordinary leader with unparalleled sense of purpose, urgency, PhD in mathematics and illustrious track record of success as a pharmaceutical industry executive with over 30 years of experience that included growing revenue, shareholder value, and accelerating innovative treatments. She began her career leading R & D at GSK with a clinical pipeline responsibility for $1.25 billion, prior to serving as CEO at Cardiokine, CEO at Avalanche, co-founder of Annapurna, SAS, CEO of Adverum, Ohana Biosciences. She currently serves on the Osler Diagnostics (UK) and AviadoBio (UK) Boards. In addition to advocating for patients living with rare diseases, Dr. Salzman leads the Stop ALD Foundation, a non-profit medical research foundation focused on developing. In this interview Amber speaks about her personal and family's struggle with neurodegenerative rare diseases and the critical new discoveries in gene regulation to switch genes on and off rather than cut DNA which she has guided and accelerated with the support of an extraordinary team of Nobel Prize laureates and scientists at Epicrispr. 0:00 - Highlight 1 - Amber's Family's Personal Struggle with Rare Neurodegenerative Disease 1:02 - Highlight 2 - Patient's Real-World Story from the 9/11 tragedy 2:31 - Highlight 3 - Vision & Stamina Needed to Address Unpredictability of Human Biology 4:03 - Speaker Introduction 7:19 - Keys to Transition from R & D to CEO/Commercial Leader 10:22 - Approach to decision-making as a leader with urgency & purpose 14:00 - Epigenetic Editing and How it is different from CRISPR 16:36 - Challenges on the journey to Epicrispr's discovery 18:14 - Second challenge - finding a gene modulator with which to fuse it 18:49 - Patients vary significantly in how they express their symptoms 19:52 - Springbuck Analytics Partnership - Whole Body Imaging 21:14 - Recent disappointments from Sarepta in Duchenne’s muscular dystrophy 25:48 - How Amber’s personal family experiences with Genetic Diseases impacted her leadership journey 29:47 - When could FSHD patients finally access this new treatment? 31:27 - What other disease conditions is Epicrispr considering in its development program?33:27 - Amber's Lessons: Stay focused on patients, learn, and co-develop treatments together

Sandra Walker is CEO, Viacern Group, and Venture Partner at Hard Climate, a seasoned and inspirational pharma and biotech executive leading Commercial, Medical Operations and Excellence, Government Affairs, Global Strategy and Product Planning at companies such as Genentech, Roche, Eli Lilly and Abbvie. She delivered a state-of-the-art, candid, and intriguing keynote presentation that forces you to reflect on the language and process you use to make decisions in medicine, healthcare, and how you can challenge your current approaches and biases using neuroscience-based practical, real-world solutions to make bolder decisions with evidence to drive innovation forward. 3:10 Speaker Introduction 4:12 Turning Innovation into Outcomes Three Common recurring Decision Patterns Explaining Biases in Decision-making Practical Solutions to Transform Decisions The Bolder Way Decision Audit 5:56 Three Invisible Decision Patterns 6:37 Status Quo Bias 8:51 Countermoves You Can Use vs Status Quo Bias 9:29 Confirmation Bias 11:54 10-Minute Challenge Round To use Vs. Confirmation Bias 13:09 Completion Bias - Relief of Feeling Done 16:30 Explaining the Brain under Pressure with Neuroscience 18:50 How to Quiet the Noise in Bias Label the state – identify the bias, problem, risk Externalize thinking – move ideas onto paper to createpublic reasoning Teach the cheerleader to celebrate learning not justfinishing. Train for Learning not Finishing 21:01 The Bolder Way - 6 steps to turn Awareness into Action B - Bias and Blind Spots visualization (see the invisible) O - Observe: Disciplined Curiosity L - Learn: Broadened Perspectives D - Decide with clarity and transparency E - Empower: Trust with Context R - Recalibrate: Boldness into Learning 27:11 Bolder Way Framework Aligned to the Scientific Method 28:02 Language You Use is Key to Decision Outcome 28:38 The Decision Audit to Deliver Clarity in 5 Minutes 31:09 How Speed of Decision Impacts the Outcome

Alex Giorgetti is a celebrated professional water polo World Champion, Olympic Silver Medalist and owner of a non-profit organization, Giorgetti Athletics where his goal it to build next generation champions ready to earn top scholarships in best U.S. universities or reach professional water polo leagues across Europe. He was a guest keynote speaker at the 4th annual Medical Innovation Olympics where he shared vivid lessons from Olympics and World Championships on maintaining a resilient mindset, the power of generating strong unity and habits in teams, Medical Innovations in analytics to personalize training to a given player or position, and tangible lessons to build winning teams in business.0:00 Team Sport is like an Orchestra - Highlight 2:22 Speaker Introduction3:25 Lessons from Championships on BusinessDiscipline, power of teamwork. Tough sport mentally and physically. Giorgetti Athletics is a non-profit organization. We teach young swimmers about water safety, teach young athletes how to achieve sports scholarships at the most competitive colleges in the U.S., reach professional leagues in Europe. Our goal is to be an inspiration for the next generation.5:15 - Secrets to 4-year Championship Streak on Italy's Water Polo Team5:59 - Team Sport is like an Orchestra Everyone needs to be connected and synchronized in the right moment or music loses its flow. Sports teams without unity lose rhythm. Unity with strong mindset is what Alex calls the magic bubble. Our winning teams during this 4-year streak won games 2 hours before we even jumped into the pool. We did not have to think or plan - we were spontaneous.8:04 - Role of Preparation, Visualization and Recovery on Winning80% of the result depends on your mindset. Visualization and Recovery are most critical9:42 What types of medical approaches did you use in those Championship teams?Cold water therapy, heart rate monitoring scans. 10:20 - Physicians were taking blood tests during 100% fatigue and pressure. This allowed our coaches to know when to rest which roles - centers who fight a lot under water. These medical analytics and tools11:44 - What role do rules and formats of competition play on the outcomes in sports and business?The pool length has shortened from 33 to 25 meters to , lower threshold for exclusions or penalties including physical contact even with one hand blocking a player.13:16 Key in Sports & Business - who is quicker to adapt & keep calm?Peace of mind. Those more calm, self-confident who understand that they have all the answers inside ultimately win.15:18 Life & Business LessonOnly 1 Good Habit can build the Best Version of Yourself

#MEDICALINNOVATION #OLYMPICSWIMMING #championmindset This is an inspirational keynote presentation on October 6, 2025, at the Opening Ceremony of the 2025 Medical lnnovation Olympics from Chris Cook, double Olympian swimmer, double Commonwealth Games Champion, World Championship Bronze Medalist, motivational speaker at companies such as Microsoft and some of the largest health systems across the globe, and consultant to the U.K.'s government's National Health Service.Chris shares three specific personal stories that span Olympic level training, building the next generation of Olympic champions, and transformation of teamwork across a Healthcare system with psychological safety. 0:00 Timeline - Highlights 2:12 - Intro: 3 Key Messages - Evidence-based Confidence, Clarity, and Psychological Safety 3:28 - Biggest lesson on Confidence during the Toughest Season (2006) 4:57 - Measure what Matters: Heart Rate, Stroke Rate, Time, Perceived Exertion 5:35 - Challenge: Beat the Average from Previous Week 5:51 - Turning Point: Started to be obsessed with Progress 7:10 - Leadership Phase after Retirement 7:27 - Ambition Programme - Team Great Britain - less than 8% of first time Olympians medal, intense build-up, media attention of the Olympics 8:35 Pilot Project of First-time Olympians Created environment for potential stars to feel like Olympians, media mock-interviews, etc. 9:41 Ambition Programme Alumni & Results307 athletes have finished this program40% represent Team GB 11% of the athletes in the program win a medal 10:12- When we get clear we level up certainty Ask it, answer it, and action it - the last one drives certainty 10:50 - Collaboration with the National Health Service in the UK New programs: 1) Creating Psychological Safety to share, contribute, and debate; 2) Radical Candor. In less than 18 months, the pilot transformed one department, then started to spread 12:34 - Teamwork thrives on Psychological Safety 12:56 - Keynote SummaryConfidence is built from evidenceWhen we are unclear, things become uncertain - Challenge to the audience!True teamwork starts when we are safe to take risks

On October 6, the Host of the 4th annual global, virtual Medical Innovation Olympics, recognized as one of the top 4 innovation challenges across the globe by Fierce Pharma in 2025, Tim Mikhelashvili, CEO and Co-Founder of Amedea Pharma, welcomed all the guests and competitors at this 16-day competition along with two industry executives on the Board and Expert Judges - Melissa Norcross, Vice President, Corporate Strategy, Hyland Software, and Eddie Power, CEO, emPower medical. 0:00 Welcome - Tim Mikhelashvili, CEO, Amedea Pharma, Host #MIO2025 1:38 Power of Gathering Leaders who do not usually Interact Together 1:58 Layer the Science - Horizontal Innovation to Master Consistency 2:21 Power of Creating Momentum - Lorne Whitehead's Domino Experiment 3:13 Leap with Defiance - Healthcare Ecosystem is hostile to Innovation 3:47 Advances in Neurocircuitry, Alzheimer's biomarkers, Wearable Devices 4:58 Why Humans are Resilient and Innovators by Design 5:36 Today We have to be More Responsible than ever, not only Resilient 6:14 Innovation in Medicine is like Building a Tall Jenga Block Tower6:54 Why MIO2025 requires Competitors to Present Multiple Times x 16 days 7:54 Goal = Feel Like Healthcare Champions Ready for Future Challenges 8:25 Melissa Norcross, PhD - Peer Group to Bring out Your Best 9:20 Eddie Power, CEO, emPower Medical - Power of Learning, Curiosity