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Our brains run on infrared light. Mitochondria in the brain absorb red and near-infrared light and use it to boost cognition and energy. And mitochondrial dysfunction is a hallmark of Parkinson's, Alzheimer's and depression. John Mitrofanis has spent 20 years on the question: If infrared light restores the mitochondria, can it save the brain cells that die in Parkinson's? John Mitrofanis is a neuroanatomist and Scientific Director of Fonds Clinatec in Grenoble, France, the research center founded by Alim-Louis Benabid, the father of deep brain stimulation. He is also an honorary Professor at University College London's Institute of Ophthalmology, and was Professor of Anatomy at the University of Sydney for over a decade. He is the author of Run in the Light: Exploring Exercise and Photobiomodulation in Parkinson's Disease. Episode show notes + practical takeaways: https://livelongerworld.com/p/jmitrofanis He explains: ◼️How infrared light and exercise release the same molecules in the brain, and what BDNF does. ◼️How red and near-infrared light restores mitochondrial function in cells that are dying ◼️How Parkinson’s may begin in the gut ◼️Why current Parkinson’s drugs and deep brain stimulation relieve symptoms but don’t stop the cells from dying ◼️ Red light and sleep: the glymphatic system, brain fog, and why he uses a helmet every day ◼️ Biophotons: the light your cells emit, and why stressed cells and healthy cells emit differently TIMESTAMPS: 00:00 Cells use light to repair each other 01:00 Red light and exercise work on the same mechanism 02:50 BDNF: the molecule both exercise and light release 06:11 Blue light suppresses melatonin, red light repairs cells 09:00 The Nobel Prize won with red light, and the laser that failed to cure cancer 14:02 What deep brain stimulation actually does 14:54 Why the Parkinson's brain becomes "very, very naughty" 16:17 The beauty of deep brain stimulation, and its limit 18:40 "You apply red light on it." And I laughed 20:57 The light-treated mice kept more dopamine cells alive 23:36 Results of red light to the brain clinical trial 24:16 Is it already too late once symptoms appear? 26:48 Where he disagrees with Glen Jeffery on how deep light penetrates 28:58 Light on the body that reached the brain 31:33 Microvesicles: how cells in trouble call for help 33:12 Does Parkinson's start in the gut? 37:32 Could you skip the device and just sit in the sun? 42:06 What other Parkinson's trials are actually running 44:43 Epilepsy, autism, and cancer 45:56 The cancer evidence that cuts both ways 47:01 What's holding the trials back 48:10 Red light and sleep 49:05 We still don't know why we sleep 01:00:17 He wears the helmet every day 01:02:27 Health Stacked 01:03:15 Red light after a heart attack 01:06:41 670, 810 or 850: which wavelength and how deep 01:11:32 Why 40 hertz seems to be the magic number 01:12:03 Does the time of day matter? 01:16:00 Biophotons: the light inside us 01:22:28 Cancer cells and UV 01:30:22 Biophotons are the frontier AASTHA, LIVE LONGER WORLD: Join 2,400+ for practical health protocols on circadian alignment, light, EMF, and non-toxic living: https://livelongerworld.com/ X: https://x.com/aasthajs Instagram: https://www.instagram.com/aasthajs/ My health stack: https://www.healthstacked.com/aasthajs LinkedIn: https://www.linkedin.com/in/aasthajs/ HEALTH PRODUCTS I LOVE: ◼️VivaRays 4 in 1 Blue Blockers and UV transmitters: https://vivarays.com/livelongerworld or discount code LIVELONGERWORLD for 10% off ◼️Healthy Home Shop Circadian Bulbs: https://thehealthyhome.shop/livelongerworld for 10% off Dr. John Mitrofanis: Profile: https://profiles.ucl.ac.uk/46795-john-mitrofanis Introducing HEALTH STACKED: https://www.healthstacked.com/ RELATED POSTS: Boost Mitochondria with Infrared & Sunlight | Glen Jeffery: https://www.livelongerworld.com/p/gjeffery 97 Year Old Brain Scientist: This One Nutrient Prevents Dementia: https://www.livelongerworld.com/p/mcrawford

Most biology textbooks treat the water in our body as background, a solvent that DNA and proteins float around in. But what if a large portion of the energy in our body is actually coming from the water in our cells? And what if a disturbance to the structure of that water is a hallmark of cancer and other diseases? Dr. Gerald Pollack is a Professor of Bioengineering at the University of Washington and one of the few scientists studying what water is actually doing inside our cells. He says water is not the background, it is doing the work. It is a battery, and it is supplying us energy. Episode show notes + some bonus clips from this episode I only released for premium subscribers, find them: https://livelongerworld.com/p/gpollackHe explains: ◼️ How 99% of the molecules in our body are water molecules, and how water is not just a background solvent ◼️ How water is a battery and gives us energy ◼️ Why every cancer cell is dehydrated with low electrical potential ◼️ The role of infrared light and sunlight on water in our cells ◼️ What builds EZ water: sun, sauna, red light, grounding, juicing, deuterium depleted water, turmeric, holy basil and ghee ◼️ The effect of Hyperbaric oxygen, PEMF and magnets on EZ water ◼️ The link between dementia and EZ water TIMESTAMPS: 00:00 Water in our cells is central to every disease 00:38 Why almost nobody in biology studies water 01:18 99% of your molecules are water. So why is it treated as filler? 03:41 What water is actually doing inside a cell 07:44 Gilbert Ling, and the book that made his students say all of biology is wrong 11:25 The experiment that started structured water research 14:09 Why cellular water behaves more like a gel than a liquid 16:29 The moment they realized water is a battery 18:29 What charges the water battery, and it isn't food 18:52 Health Stacked 19:43 Is all the water in your cells this kind of water? 23:46 Why he says we shouldn't even call it water 24:57 Does energy actually come from ATP? 27:23 If ATP isn't the fuel, what is it doing there? 30:38 What every cancer cell has in common 33:47 Free things that rebuild the structure of your cellular water 34:48 Turmeric, holy basil and ghee: what his lab found when they tested them 35:11 Morning sun, red light, saunas and grounding 36:22 Hyperbaric oxygen, and how he went looking for it 37:26 PEMF, FSM, and the magnet result that surprised him 41:42 Do WiFi routers shrink the water in your cells? 43:47 The dementia case & water connection 46:32 His answer to the strongest criticism of his work 51:13 Healers, water memory, and the paper he's about to publish 54:36 What anesthesia does to the water in your cells 55:07 What changes if he turns out to be right 57:30 One thing behind almost every disease? 59:07 Why he thinks water drives volcanoes and earthquakes AASTHA, LIVE LONGER WORLD: Join 2,400+ for practical health protocols on circadian alignment, light, EMF, and non-toxic living: https://livelongerworld.com/ X: https://x.com/aasthajs Instagram: https://www.instagram.com/aasthajs/ My health stack: https://www.healthstacked.com/aasthajs LinkedIn: https://www.linkedin.com/in/aasthajs/ HEALTH PRODUCTS I LOVE: ◼️VivaRays 4 in 1 Blue Blockers and UV transmitters: https://vivarays.com/livelongerworld or discount code LIVELONGERWORLD for 10% off ◼️Healthy Home Shop Circadian Bulbs: https://thehealthyhome.shop/livelongerworld for 10% off ◼️Daylight Computer No-blue screen: https://buy.daylightcomputer.com/livelongerworld for $25 offFull list of health products I use: https://www.healthstacked.com/aasthajs Dr. Gerald Pollack: Website: https://www.pollacklab.org/ Books: https://www.pollacklab.org/publications RELATED POSTS: Avoiding the sun kills more people than skin cancer: https://www.livelongerworld.com/p/sunsmoking I covered my WiFi router in foil & reduced EMF radiation 50x: https://www.livelongerworld.com/p/emfphone Why I Stopped Taking Vitamin D Supplements: https://www.livelongerworld.com/p/vitd

Oxford physiologist Denis Noble reveals why your genes are not the blueprint for life, why evolution itself works nothing like the selfish gene made us believe, and why the failed promise to cure disease by reading our DNA points to a completely different understanding of health and aging! Denis Noble built the first working mathematical model of the heart in 1960 and is one of the founding figures of systems biology. He is a professor at Oxford with a career spent studying how living systems work, and he now argues that the genome is a database the living cell draws on, not the program running the show. He explains: ◼️Why the Human Genome Project never delivered the cures we were promised ◼️Why your DNA cannot actually predict most disease ◼️The CD analogy: why studying genes tells you nothing about the music of life ◼️His long-running clash with Richard Dawkins and the selfish gene ◼️Why purpose and intelligence run all the way down, from your immune system to a predator hunting its prey Episode Show Notes: https://livelongerworld.com/p/denisnoble TIMESTAMPS: 00:00 The Selfish Gene Is Just Not Correct 00:21 What Are Functional Networks, Really? 02:09 Genes Build the Muscles, But Don't Move Them 09:42 Your Genes Are a CD, Not the CD Player 12:11 Can Your DNA Predict Your Disease? 14:23 If Not Genes, How Do We Find Cures? 18:18 Then Does Gene Therapy Even Work? 21:32 Why Scientists Can't Let the Paradigm Go 24:08 What Darwin and Lamarck Actually Said 31:42 Do Animals Choose? Darwin Thought So 38:07 The Finite Monkeys Problem With Evolution 45:15 Inheritance Without Changing Your DNA 49:31 How Do You Actually Reproduce Denis Noble? 50:49 Is the Selfish Gene Right From Evolution's View? 54:45 Answering Jerry Coyne: Isn't DNA the Recipe? 59:51 Who Wrote the Genetic Code? 1:08:22 The Problem of Form: You Can't Get It From Genes 1:12:01 The Mitochondria Accident That Made Complex Life 1:13:05 Why Big Life Needs a Heart 1:17:54 Why Mars Is a Pipe Dream 1:18:45 Mike Levin and the Alignment of the Body 1:21:29 What Does Denis Disagree With Mike Levin On 1:24:59 The Biggest Taboo: Purpose in Biology 1:27:35 Is Consciousness Just Expensive Energy? 1:28:55 What Your Immune System Knows 1:42:01 How Birds at Altitude Prove the Point 1:44:29 Final Thoughts: Life Is More Interesting Than You Think DENIS NOBLE: Website: https://www.denisnoble.com/ Books: https://www.denisnoble.com/buy/ AASTHA, LIVE LONGER WORLD: Newsletter: https://livelongerworld.com/ X: https://x.com/aasthajs Instagram: https://www.instagram.com/aasthajs/ My health stack: https://www.healthstacked.com/aasthajs Full list of health products I use: https://www.healthstacked.com/aasthajs CAMERON, RICCI FLOW NUTRITION: Newsletter: https://ricciflow.substack.com/ X: https://x.com/ricciflowhealth Instagram: https://www.instagram.com/ricciflownutrition/ PREVIOUS PODCAST WITH DENIS NOBLE & MICHAEL LEVIN on Biology's Functional Networks, NOT Genes, are key for Longevity: https://www.youtube.com/watch?v=0_Ak-1rbbWg&t=3823s

Circadian scientist Dr. Martin Moore-Ede reveals why the LED bulbs in nearly every home may be driving a rise in breast and prostate cancer, why he calls the light we now live under the tobacco of our time, and why the modern fear of the sun may be shortening our lives instead of protecting them! Dr. Moore-Ede discovered the master circadian clock in the human brain, the suprachiasmatic nucleus, and ran a sleep and circadian research lab at Harvard Medical School for two decades. He has spent 50 years studying how light governs human health, and now argues that the shift to blue-rich LED lighting has created an environment our bodies were never built for. He explains: ◼️ Why breast, prostate, and colorectal cancer track almost exactly with how much electric light a society uses ◼️ Why melatonin is not the sleep hormone you think it is, and what it really does at 2am ◼️ How LEDs strip out the red and infrared your mitochondria need for energy ◼️ Why the sun exposure data flips skin cancer advice on its head ◼️ Why your children are going short-sighted, and the wavelength that prevents it ◼️ Why the $200 blue-light glasses most people buy block the wrong blue AASTHA, LIVE LONGER WORLD: Episode Show Notes: https://livelongerworld.com/p/mmooreede X: https://x.com/aasthajs Instagram: https://instagram.com/aasthajs My health stack: https://www.healthstacked.com/aasthajs TIMESTAMPS: 00:00 LED Light Is the Tobacco of Our Time 01:33 The Connection Between Cancer and LED Lighting 04:05 Why Hormone-Driven Cancers Are Hit the Hardest 07:49 Is There a Link to Glioblastoma? 08:14 Why Melatonin Is Not the Sleep Hormone 11:40 There Is No Blue Light in Nature After Sunset 15:58 We Live in Junk Light, Just Like Junk Food 17:21 What Wavelengths Are LEDs Actually Missing? 20:44 The Infrared We Lost When We Banned Incandescents 22:52 The Two Ways LEDs Are Harming You 30:05 Health Stacked 30:56 White vs Yellow Light: Why It's the Wrong Question 33:59 Lux, Lumens, and a 100-Year-Old Mistake 38:27 What LED Light Does to Your Heart and Immune System 40:44 Why Regularity Matters as Much as the Light Itself 43:07 The Camping Study That Reset Everyone's Body Clock 49:56 Sunlight vs Skin Cancer: We Have It Backwards 53:03 The 450 vs 480 Spike Almost No One Gets Right 59:52 Why Life Evolved to Run on Blue Light 01:03:13 Melanopsin: Your Body's Blue Detector 01:08:28 Do Melatonin Supplements Actually Do Anything?01:12:19 Why the Wrong Side of a Time Zone Can Kill You 01:15:37 Is There Something Special About Dawn? 01:17:12 Light and the Early Onset of Puberty 01:20:53 The Aggressive Kid Who Changed When the Lights Did 01:21:51 Should You Replace Your Windows? 01:24:00 Do not wear sunglasses in the morning! 01:26:44 What About Daytime Lighting? 01:27:41 Do Blue-Light-Blocking Glasses Work at Night?01:31:20 Take Your Lighting Into Your Own Hands PRODUCTS I USE FOR BETTER CIRCADIAN RHYTHM: ◼️VivaRays 4 in 1 Blue Blockers: https://vivarays.com/livelongerworld or code LIVELONGERWORLD for 10% off ◼️Healthy Home Shop Circadian Bulbs: https://thehealthyhome.shop/livelongerworld for 10% off ◼️Daylight Computer No-blue screen: https://buy.daylightcomputer.com/livelongerworld for $25 off ◼️Chroma Circadian-Aligned Desk Lamp: https://getchroma.co/photonsfromaastha and code LIVELONGERWORLD for 10% off Full list of health products I use: https://www.healthstacked.com/aasthajs Dr. Martin Moore-Ede: Website: https://thelightdoctor.com/ Book: THE LIGHT DOCTOR: Using Light to Boost Health, Improve Sleep, and Live Longer: https://amzn.to/4yrwWWu HEALTH STACKED, the trusted longevity marketplace: https://www.healthstacked.com/ RELATED POSTS: Avoiding the sun kills more people than skin cancer: https://www.livelongerworld.com/p/sunsmoking Your Lights are Wrecking your Sleep (Here’s What I Use): https://www.livelongerworld.com/p/redlights Your Screens Are Keeping You Awake: 60 second fix: https://www.livelongerworld.com/p/redphone

97-Year-Old Brain Scientist Professor Michael Crawford reveals why the human brain has been physically shrinking for thousands of years, why he believes it was DHA, an omega-3 fat from the sea, and not your genes, that built human intelligence, and why the official advice to limit fish in pregnancy may be harming an entire generation of babies! Professor Michael Crawford is Director of the Institute of Brain Chemistry and Human Nutrition and a visiting professor at Imperial College London, with more than 300 published papers and the 1972 work that first linked DHA to the evolution of the human brain. At 97, he is still sharp, still publishing, and still arguing that modern nutrition has neglected the one organ that makes us human. He explains: ◼️ Why the brain physically cannot work without DHA, full stop ◼️ Why it was DHA, not DNA, that shaped the human brain ◼️ Why he says the FDA is wrong about limiting fish in pregnancy ◼️ How seed oils quietly crowd this fat out of your brain cells ◼️ Whether dementia and Alzheimer's actually begin in the womb ◼️ Why humans could only have evolved big brains beside the sea ◼️ How chicken and eggs lost almost all of their brain fat ◼️ Why he believes DHA works like a semiconductor in your neurons Episode Show Notes: https://livelongerworld.com/p/mcrawford Find me on X: https://x.com/aasthajs Instagram: https://instagram.com/aasthajs My health stack: https://www.healthstacked.com/aasthajs TIMESTAMPS: 00:00 The Brain Food We Stopped Eating 00:32 "Your Brain Won't Work Without DHA. That's just full stop" 04:04 It Wasn't DNA That Made Us Human 06:50 How the Eye Built the Brain 08:00 Why Carnivores Are Sharper Than Herbivores 11:35 The Flowering Plant That Invented Pregnancy 14:22 The Placenta: An Organ Built From One Fatty Acid 15:35 Why Arachidonic Acid Is Wrongly Demonized 18:18 More Astrocytes Than Neurons: Who Really Runs the Brain 21:39 Health Stacked 22:38 DHA vs Arachidonic Acid: Two Different Origins 25:21 How the Fetus Hoards DHA and Rejects the Rest 30:31 Are Seed Oils Actually Starving Your Brain? 32:24 Why the FDA is wrong about Fish in Pregnancy 37:50 Do Fish Oil Supplements Work? 44:15 The Lack of Fish in Pregnancy is causing ADHD and Austism 50:10 Why Governments Only Care About Body Size, Not Brains 52:00 "A Race of Morons": The Warning From 1972 55:04 Does Dementia Actually Begin in the Womb? 59:16 Does the Father's Nutrition Matter Too? 59:40 The Importance of Arachidonic Acid that Infant Formula Leaves Out 01:02:24 How Often You Should Actually Eat Seafood 01:04:05 Can Vegetarians and Vegans Get Enough? 01:05:04 Can Genetics Let You Skip Seafood? The India Case 01:08:00 Why Humans Could Only Have Evolved Beside the Sea 01:11:55 Farming the Sea: What Japan Figured Out 01:17:22 The Collapse of DHA in Chicken and Eggs 01:20:52 Why Corn-Fed Everything Is Lower in DHA 01:22:32 The Semiconductor Theory of the Brain, Explained 01:27:20 What Dr. Crawford's Vision Is Like at 97 years old 01:28:39 The Rare Double-DHA Molecule in Your Retina 01:29:23 Where Dr. Crawford Lands on Saturated Fat 01:31:09 His Advice to Young Scientists: Challenge Everything 01:32:07 Closing: Why This Is a Three-Generation Emergency AASTHA, LIVE LONGER WORLD: Join 2,100+ for practical health protocols on circadian alignment, light, sleep, non-toxic living and more: https://livelongerworld.com/ X: https://x.com/aasthajs Instagram: https://www.instagram.com/aasthajs/ My health stack: https://www.healthstacked.com/aasthajs Dr. Michael Crawford:Book The Shrinking Brain: https://amzn.to/4vEJiZ3Introducing HEALTH STACKED: https://www.healthstacked.com/ I built the health store I’ve always wanted. Health Stacked is a vetted marketplace of 500+ health and longevity products across 12 categories like sleep, fitness, non-toxic home, lighting & EMF, and more. Products are screened for plastic, PFAS, and 20+ toxins. Inclusion is 100% merit-based. And every product has been hand-picked by me.

Is a hidden molecule in your food and water silently fueling cancer, Alzheimer's, and Parkinson's? Could the supplements you trust every day be making it worse? Dr. Stephanie Seneff is a senior research scientist at MIT (published in PNAS, Frontiers, FASEB) with a career studying nutrition, biology, and toxicology. In this conversation, she explains why deuterium — a heavier form of hydrogen — may be the most underrated driver of chronic disease, why cancer might be the body's repair response to deuterium-damaged mitochondria, and why most supplements may backfire. We discuss: ◾ Why deuterium may be the most important molecule you've never heard of ◾ How glyphosate stops your body from clearing deuterium ◾ The two supplements you should stop taking immediately ◾ Why she says: "I don't believe in supplements" ◾ Why chemo may be working backwards on cancer ◾ How to make your gut produce low-deuterium water ◾ The folic-acid-in-pregnancy and autism connection ◾ Why she drinks deuterium-depleted water every day This is Dr. Seneff's second appearance on Live Longer World. Her first episode on glyphosate is linked below. Episode Show Notes: https://livelongerworld.com/p/sseneff2 Find me on X: https://x.com/aasthajs My health stack: https://www.healthstacked.com/aasthajs TIMESTAMPS: 0:00 Why deuterium might be the most important molecule you've never heard of 5:09 The hidden reason processed food is wrecking your health 7:25 How deuterium breaks your mitochondria 11:02 Glyphosate stops your body from rationing deuterium (and the osteoporosis link) 18:23 Health Stacked 19:07 No one is connecting gut health to deuterium, until now 22:45 The two nutrients that help your gut clear deuterium 25:29 Methylation, melatonin, and protecting your mitochondria 33:14 Why melatonin supplements don't actually work 34:08 The two supplements you should stop taking immediately 38:06 How to make your gut produce low-deuterium water 41:12 How glyphosate suppresses your MTHFR gene 43:21 Why folate supplementation is a problem 45:06 "I don't believe in supplements", Stephanie's case against them 46:02 Why she's suspicious of fish oil 47:47 The folic-acid-in-pregnancy and autism connection 52:37 How glyphosate is quietly causing bone problems 56:22 Inflammation is really a deuterium problem 1:01:25 Gerald Pollack's EZ water and how your cells expel deuterium 1:04:59 Why breast milk is low in deuterium 1:09:03 Cancer's real job: repairing your mitochondria (and why chemo may be a mistake) 1:23:14 How deuterium-depleted water may help heal cancer 1:26:57 Deuterium and Parkinson's: how plaque traps it 1:30:37 How to fight Parkinson's 1:33:55 Why Stephanie drinks deuterium-depleted water every day 1:36:37 What glyphosate does to your sulfation system 1:38:38 How grounding reduces deuterium 1:39:42 Jack Kruse on glyphosate and melanin 1:40:08 Are seed oils high in deuterium? 1:45:05 Does where you live (and sunlight) affect your deuterium? 1:47:05 Practical tips to manage your deuterium load Dr. STEPHANIE SENEFF: Website: https://stephanieseneff.net/ X: https://x.com/stephanieseneff AASTHA, LIVE LONGER WORLD: Join 2,000+ others for practical health protocols on circadian alignment, light, sleep, & non-toxic living: https://livelongerworld.com/ X: https://x.com/aasthajs Instagram: https://www.instagram.com/aasthajs/ My health stack: https://www.healthstacked.com/aasthajs Introducing HEALTH STACKED: https://www.healthstacked.com/ I built the health store I’ve always wanted. Health Stacked is a vetted marketplace of 500+ health & longevity products across 12 categories like sleep, fitness, non-toxic home, lighting & EMF, and more. Products are screened for plastic, PFAS, and 20+ toxins. Inclusion is 100% merit-based. And every product has been hand-picked by me. RELATED EPISODES: Glyphosate Toxicity & Deuterium's Role in Cancer, Celiac, Aging | Dr. Stephanie Seneff: https://open.spotify.com/episode/4HFmNT0fLCckXvrC1XRSFt?si=cSv7wuPPTm2wE5YSMY2L3w

The standard “wear and tear” story of aging may be incomplete. Dr. Peter Lidsky—a virologist and evolutionary biologist argues that aging is programmed. He says aging can be an adaptive strategy for controlling pathogens, a concept he calls the “pathogen control hypothesis.” In this episode, we dig into the evidence behind this idea, the immune system in aging, and what his theory means for longevity interventions. Episode Show Notes: https://livelongerworld.com/p/plidskyFind me: https://x.com/aasthajs My longevity products: https://www.livelongerworld.com/p/2024TIMESTAMPS:0:00 — Aging ≠ Wear-and-Tear 3:44 — The Case for Programmed Aging 8:48 — Why Program Aging at All? 11:09 — The Pathogen-Control Hypothesis 14:26 — Why We Get “Sick Time” 24:37 — Rising Lifespans, Explained 27:36 — Bowhead Whales’ Longevity Edge 31:15 — Why Lone Animals Don’t Live Forever 34:00 — Planaria: The “Immortal” Worm 35:00 — Do Infections Speed Up Aging? 36:46 — When Immunity Starts to Slide 38:17 — Why Fertility Has a Deadline 42:49 — Extending Life via the Immune System 1:00:35 — How Honey Bees Rejuvenate 1:10:50 — Can We Tackle Aging? Healthspan to 90s+AASTHA, LIVE LONGER WORLD:X: https://x.com/aasthajs Newsletter: https://livelongerworld.com/Instagram: https://www.instagram.com/aasthajs/Peter Lidsky: https://www.cityu.edu.hk/bms/profile/peterlidsky.htmRELATED:Dr. Geoffrey West | Scaling Laws in Longevity & Aging: https://youtu.be/T67U8IK_1RU?si=ajq5AbjM6ufBQ7WfDr. David Gems | Hyperfunction & Programmatic Theory of Aging & Critique of Hallmarks of Aging: https://youtu.be/rLD-8UhHEZM?si=R_x_mLguTAKfdXtQDr. Bjorn Schumacher | DNA Damage & Aging, p53 & Cancer, and DNA repair in Reproductive Cells: https://youtu.be/kjQ-SwEP1bo?si=G2mEtNZs1O7TsLKe

“We can use the rule of evolution to optimize cancer therapy. The standard practice is that any therapy is given at maximum tolerated dose continuously until progression. It's almost a mantra that they have. Evolutionarily, you could hardly do it worse.” The current treatments on cancer do not account for how evolution works. Dr. Robert Gatenby has been studying evolutionary and game theory dynamics in the progression of cancer. He established the first cancer biology and evolutionary program in the U.S. We can leverage this evolutionary information to provide more effective cancer treatment, which he discusses in this episode. Dr. Michael Levin is my co-host.Episode Show Notes: https://livelongerworld.com/p/rgatenbyFind me: https://x.com/aasthajs My longevity products: https://www.livelongerworld.com/p/2024TIMESTAMPS:0:00 – Cancer as Tissue Damage, Not Just Mutations8:48 – How Evolution Supercharges Cancer Cell Fitness11:04 – Debunking the “Primitive Cell” Myth12:06 – The Herd Mentality of Cancer Cells14:57 – Why Cancer Dynamics Go Beyond the Genome22:27 – Networks and Information Flow Inside Cells26:56 – Shared Goals: The Secret to Cellular Cooperation29:55 – Genome = Hardware, Information = Software36:26 – Healthy vs. Cancer Cells: Competing Information Systems39:05 – Evolution Turns Harsh After Reproduction41:03 – How Cancer Rewrites Its Own Information Playbook43:07 – Adaptive Therapy: A Patient’s Guide50:45 – The Limits of Adaptive Therapy53:12 – Hunting for Better Cancer Biomarkers55:11 – The Tumor Microenvironment’s Hidden Role59:42 – Why We Must Look Beyond Genetic DataAASTHA, LIVE LONGER WORLD:X: https://x.com/aasthajs Newsletter: https://livelongerworld.com/Instagram: https://www.instagram.com/aasthajs/LINKS:Michael Levin: https://x.com/drmichaellevinRobert Gatenby: https://www.moffitt.org/inspiring-stories/dr.-gatenbys-storyEpisode Show Notes: https://livelongerworld.com/p/rgatenbyALSO WATCH:The First Cancer Cell: A Revolution in Early Detection | Michael Levin & Azra Raza: https://open.spotify.com/episode/7yW6ZVVdQkboWpldUZyenD?si=obYEC22NSsSyy7j09JBf7QKeto & Metabolic Therapy for Cancer | Dr. Thomas Seyfried: https://open.spotify.com/episode/7tYdjcJ3G4tqbAx9Z6Bix2?si=Yz9CQ-wNQ3WdcwjKw3lXGwWhy Viruses Could Be the Cause of Chronic Disease | Dr. Paul Ewald: https://open.spotify.com/episode/2OdYInlzTy2zG3Mi6TgADY?si=BtishVk_R-28K2KypODIog

Mitochondria might be one of the most important organelles inside our cells. Best known as the cell’s powerhouse, they don’t just make energy; they regulate metabolism, control cell death, drive immune function, and may even be the reason multicellular life exists at all! It’s no surprise they’re implicated in nearly every major disease, from heart disease and cancer to neurodegeneration, especially as they decline with age. What if we could slow or even reverse that decline by giving cells fresh, healthy mitochondria? That’s the promise of mitochondrial transplantation—a groundbreaking approach Mitrix Bio is pioneering. In this episode, I talk with CEO Tom Benson about the science, the potential, and the early results from people already lining up for their trial. Episode Show Notes: https://livelongerworld.com/p/tbenson Find me: https://x.com/aasthajs My longevity products: https://www.livelongerworld.com/p/2024 TIMESTAMPS: 00:00 - Injecting new mitochondria into your body 01:39 - Mitochondria’s evolutionary role in aging 04:35 - What happens to old mitochondria? 06:18 - Why humans live longer than other animals 11:30 Why cardiovascular disease is #1 killer 12:30 - Why does the brain remain sharp with age? 15:30 Why does energy decline after age 30? 19:04 Why doesn’t the body correct mitochondrial mutations? 22:42 Mitochondrial defects in children 24:14 Diagnostics for mitochondrial health 27:36 Mitochondrial DNA is eternal 33:18 Where does mitochondria come from in mitochondrial transplantation? 34:59 Growing mitochondria in a bioreactor 39:07 How neurons grow their mitochondria 40:52 Mitochondrial theory of cancer 44:23 Mitochondria and psychobiology 48:32 Chemotherapy and radiation damage mitochondria 50:38 Evidence that mitochondrial transplantation works 56:06 Caloric restriction, sauna, sunlight, and mitochondria 1:00:01 Mitochondria and races 1:02:57 Why stop at 130 years old? 1:04:48 Why might this not work? 1:10:03 Volunteers for Mitrix trial AASTHA, LIVE LONGER WORLD: X: https://x.com/aasthajs Newsletter: https://livelongerworld.com/ Instagram: https://www.instagram.com/aasthajs/ Mitrix Bio: https://mitrix.bio/ Tom Benson: https://mitrix.bio/team/tom-benson/ RELATED: New Spin to the Free Radical Theory of Aging: https://www.livelongerworld.com/p/ros Keto & Metabolic Therapy for Cancer | Dr. Thomas Seyfried: https://open.spotify.com/episode/7tYdjcJ3G4tqbAx9Z6Bix2?si=biOOH1e5RpeZduLJv2fPHw Boost Mitochondria with Sunlight and Infrared light: https://open.spotify.com/episode/1jGfhzX1P245LU2kLwgHTq?si=yPOC3bViRnmOUeR-P0jeWA

Can we detect cancer so early such that we find the very first cell of cancer? Not just stage 1 cancer, but the first cell of cancer. In this episode, Dr. Michael Levin and I speak with Dr. Azra Raza. She is an oncologist pioneering early detection of cancer using electric signals. So far, our best solution to curing cancer has been to detect it early, and she wants to take this further, by nipping cancer at the very first cell. Her story with cancer is also deeply personal as she lost her husband to the disease. You can see in the episode how much she cares about solving cancer through early detection, and how aggrieved she is about the fact that not only have we made zero progress on cancer in the last 100 years, but doctors are also not focused on cancer prevention. Dr. Raza is also the author of the book The First Cell: And the Human Costs of Pursuing Cancer to the Last. Episode Show Notes: https://livelongerworld.com/p/araza Find me: https://x.com/aasthajs My longevity products: https://www.livelongerworld.com/p/2024 TIMESTAMPS: 0:00 New theory of cancer 1:45 What causes cancer? 5:39 Hybrid cells in cancer 11:16 Why do cancer cells become immortal? 14:14 Detecting the first cell of cancer 17:09 Stress causes cancer cells to fuse 21:40 Cancer drugs don’t work universally 25:54 Personalization of early cancer detection 29:29 Detect cancer early using electrics 35:46 Anguish of cancer patients 39:06 Cancer progress hasn’t moved in 100 years 44:04 Doctors don’t think of cancer prevention 46:54 First Cell Therapeutics - Azra’s company 50:55 What is the first cell stage of cancer? 54:55 Advice for cancer patients AASTHA, LIVE LONGER WORLD: Twitter: https://x.com/aasthajs Newsletter: https://livelongerworld.com/ Instagram: https://www.instagram.com/aasthajs/ LINKS: Michael Levin: https://twitter.com/drmichaellevin Azra Raza: https://azraraza.com/ Azra Raza book The First Cell: https://amzn.to/4jGJzoJ Episode Show Notes: https://livelongerworld.com/p/araza RELATED EPISODES: Keto & Metabolic Therapy for Cancer | Dr. Thomas Seyfried: https://open.spotify.com/episode/7tYdjcJ3G4tqbAx9Z6Bix2?si=gboyPAiLQrqg-y5YEKQiQQ Why Viruses Could Be the Cause of Chronic Disease | Dr. Paul Ewald: https://open.spotify.com/episode/2OdYInlzTy2zG3Mi6TgADY?si=Gnbg7efNSy21bS3q0c23jg

What if chronic diseases like cancer and Alzheimer’s are caused by infections we’ve overlooked? We assume chronic disease is caused by genetics and / or lifestyle. However, evolutionary biologist Dr. Paul Ewald says latent viruses and pathogens play a critical hidden role in many diseases. For example, we already know that Human Papillomavirus (HPV) causes cervical cancer. And research indicates how the EBV virus shows up in Multiple sclerosis, and chlamydia pneumonia shows in Alzheimer’s. Deeper investigation into viruses and disease is warranted and will help with better diagnosis and treatment. Dr. Paul Ewald is also the author of Plague Time: The New Germ Theory of Disease, and Evolution of Infectious diseases. Episode Show Notes: https://livelongerworld.com/p/pewaldFind me: https://x.com/aasthajs My longevity products: https://www.livelongerworld.com/p/2024TIMESTAMPS:0:00 Role of infection in chronic disease is neglected 2:40 Role of viruses in Alzheimer’s 10:50 Connections between Alzheimer’s, diabetes, cardiovascular disease 15:57 Genes cannot explain the full reason for disease 20:47 Strong association between Alzheimer’s, chlamydia pneumonia, and APOE4 28:16 Multiple sclerosis and EBV virus 35:08 Latent viruses may in fact be active & cause cancer 41:41 Sexually- transmitted pathogens correlated with cancer 46:50 Viruses that cause cancer (EBV & breast cancer) 53:09 Hodgkin’s lymphoma and virus 57:15 Stanford study showing EBV as leading cause of MS 1:00:19 Do viruses attack the mitochondria and cause cancer 1:01:38 Glioblastoma and virus / antiviral treatment 1:07:07 Virus vs. oncogenes causing cancer 1:14:17 Breast cancer BRAC1 mutations & virus association 1:15:59 Vaccines against viruses 1:17:56 Practical steps if you test positive for infectious viruses 1:24:57 Could cancer relapse be due to persistent virus 1:27:48 Protect the immune system 1:29:38 Areas Dr. Ewald is excited aboutAASTHA, LIVE LONGER WORLD:X: https://x.com/aasthajs Newsletter: https://livelongerworld.com/Instagram: https://www.instagram.com/aasthajs/PAUL EWALD LINKS:Plague Time: The New Germ Theory of Disease: https://amzn.to/3FXjOSuEvolution of Infectious diseases: https://amzn.to/3FYaqOvEpisode Show Notes: https://livelongerworld.com/p/pewaldALSO WATCH:Keto & Metabolic Therapy for Cancer | Dr. Thomas Seyfried: https://open.spotify.com/episode/7tYdjcJ3G4tqbAx9Z6Bix2?si=biOOH1e5RpeZduLJv2fPHw

What if our cells have memory and cognition, which changes how medicine is done? In this conversation with Dr. Pamela Lyon and Dr. Michael Levin, we discuss: - Cognition and creativity is not merely associated with the brain and nervous system - Implications of this view of cognition for regenerative medicine and longevity - Is stress response the source of our creativity? Episode Show Notes: https://livelongerworld.com/p/plyon Find me: https://x.com/aasthajs My longevity products: https://www.livelongerworld.com/p/2024 TIMESTAMPS: 0:00 Intro, Basal cognition 1:00 Our view of cognition is incorrect 8:50 What does biology have to say about cognition? 12:12 Cognition in xenobots 14:20 Cognition and cooperation in microbes 30:03 Bioelectricity and cognition 33:58 Is stress response the source of our creativity? 43:27 Mike’s paper: Stress-sharing as a cognitive glue 47:31 Implications of cognition not only being associated with brain 56:55 Cognition in AI 1:02:33 View of cognition in the East AASTHA, LIVE LONGER WORLD: Twitter: https://x.com/aasthajs Newsletter: https://livelongerworld.com/ Instagram:https://www.instagram.com/aasthajs/ LINKS: Michael Levin: https://twitter.com/drmichaellevin Pamela Lyon: https://www.adelaide.edu.au/directory/pamela.lyon# Episode Show Notes: https://livelongerworld.com/p/plyon ALSO WATCH: Michael Levin & Denis Noble on What Biology Needs to Advance Longevity: https://open.spotify.com/episode/49WaTa4Vl67FU4zjjX1H6F?si=x1rjzVocS2OjSVdxpzNt5g

We’re only just waking up to the benefits of sunlight and red light for mitochondrial health, lowering blood glucose, and potentially treating Parkinson’s disease and cancer. Dr. Glen Jeffery is at the leading edge of this research. We discuss: - Health benefits of sunlight and red light - Harmful effects of blue light & LEDs - In the 2nd half of the podcast, I ask him rapid fire practical questions that everyone wants to know about light, ranging from how much sunlight should one get to what time of day is best for infrared light exposure. Episode Show Notes: https://livelongerworld.com/p/gjeffery Find me: https://x.com/aasthajs TIMESTAMPS: 0:00 Intro 0:59 Light impact on public health 3:08 Light research is understudied, mitochondria is impacted by light 6:05 Red and blue light impacts on mitochondria 8:25 Benefits of red light - wound healing, lower glucose 15:09 Are there downsides to red light? 16:59 Does time of day impact red light benefits? 22:05 Red light and cancer 26:00 Blue light is making you pre-diabetic 37:46 n=1 light experiments 39:22 Mitochondria & Longevity 46:21 “Sunlight offers a unique package” Rapid fire questions: 53:40 Is sunlight good enough for red light? 55:10 How much sunlight do we need? 56:07 When should you get sunlight? 56:55 Should you worry about afternoon sunlight? 58:57 Can you get sunlight on cloudy days? 59:38 Does sunscreen mitigate benefits of sunlight? 1:00:12 Should you not wear caps and sunglasses in sunlight 1:01:43 Clothing and sunlight 1:05:52 Sunlight through window? 1:06:16 Are blue light blocking glasses helpful? (see 1:19:31 for more context) 1:08:17 Do Artificial sunlight lamps work? 1:08:51 What wavelength red light is the best? 1:10:56 Time in front of red light device 1:12:41 Body exposure to red light 1:15:37 Lighting at home at night 1:19:31 Differences in blue light for mitochondria vs. circadian biology 1:24:18 Stop using LEDs 1:25:24 Does light impact the bioelectrics of the mitochondria? 1:26:55 Mitochondria in melatonin mop up ROS 1:31:29 Benefits of fire light? 1:35:33 Open questions on light and health 1:37:28 Support Live Longer World AASTHA, LIVE LONGER WORLD: X: https://x.com/aasthajs Newsletter: https://livelongerworld.com/ Instagram: https://www.instagram.com/aasthajs/ DR. GLEN JEFFERY: Bio page: https://profiles.ucl.ac.uk/7465-glen-jeffery/publications ALSO WATCH:- Keto & Metabolic Therapy for Cancer | Dr. Thomas Seyfried: https://open.spotify.com/episode/7tYdjcJ3G4tqbAx9Z6Bix2?si=rHlCwLVqQHqiOB7yTVBtgQ

Dr. Thomas Seyfried challenges the existing paradigm that says cancer is a genetic disease. He says that instead cancer is caused by damage to the mitochondria. Understanding this completely overturns the management and prevention of cancer. He is a Professor of biology, genetics, and biochemistry at Boston College. He has over 150 peer-reviewed publications and is also the author of books such as, ‘Cancer as a Metabolic Disease: On the Origin, Management, and Prevention of Cancer’. WE DISCUSS: - Why cancer is not a genetic disease - Why cancer is a metabolic disease originating from damage to the mitochondria - How metabolic therapy, management of glucose and glutamine, can be used to manage cancer - His December 2024 paper outlining a proposal for ketogenic metabolic therapy in glioblastoma Episode Show Notes: https://livelongerworld.com/p/tseyfried Find me: https://x.com/aasthajs TIMESTAMPS: 0:00 Cancer is not a genetic disease 5:04 Origins of somatic mutation theory of cancer 8:04 Mitochondrial damage causes cancer 13:42 Is mitochondrial dysfunction involved in every cancer 16:14 Mitochondria in cancer cells ferment 21:52 Target glucose and glutamine to manage cancer 28:51 Hyperbaric Oxygen therapy for cancer 31:04 December 2024 study: Role of glutamine in cancer 33:35 Can metabolic therapy be done at any stage of cancer 36:44 Combine chemotherapy with metabolic therapy 38:05 Drugs to target glutamine 40:30 People will say “I want metabolic therapy” 44:04 “Failure to understand biology” 47:48 National Cancer Institute’s take on Dr. Seyfried’s theory 49:34 Why does Peter Attia think cancer is a genetic disease 53:09 “I think about this 24/7; we’re right!” 55:56 Glioblastoma treatment protocol study 59:22 Resistance to breakthrough ideas in science 1:01:40 Radiation fuels cancer! 1:04:52 Current standard of care is responsible for poor survival rate in glioblastoma 1:07:14 Metabolic therapy for epilepsy, Parkinson’s, Alzheimer’s 1:12:22 How to prevent cancer 1:13:49 Young, healthy individuals in their 20s, 30s with cancer 1:15:05 Resources on following metabolic therapy 1:17:43 How to support Dr. Seyfried’s research 1:18:51 New cancer questions Dr. Seyfried is researching 1:21:32 Closing thoughts AASTHA, LIVE LONGER WORLD: X: https://x.com/aasthajs Newsletter: https://livelongerworld.com/ Instagram: https://www.instagram.com/aasthajs/ DR. THOMAS SEYFRIED: X: https://x.com/tnseyfried Bio page: https://www.bc.edu/bc-web/schools/morrissey/departments/biology/people/faculty-directory/thomas-seyfried.htmlCancer as a Metabolic disease book: https://amzn.to/3WBF31D RELATED EPISODES: The Cancer-Diet Connection & Otto Warburg - Nobel Prize Scientist under Hitler | Sam Apple, Author of Ravenous Modified Ketogenic Diet for Optimal Health & Exercise | Dr. Dominic D'Agostino Ketogenic Diet for Brain Health & Longevity | Dr. Dominic D'Agostino The Evolutionary Theory of Cancer | Charley Lineweaever Bioelectricity and Cancer w/ Michael Levin

Denis Noble and Michael Levin - two great minds in biology come together on Live Longer World. Denis Noble is a renowned biologist and pioneer in systems biology, known for his groundbreaking work on the electrical activity of the heart and his influential contributions to the understanding of biological systems. Denis is an advocate for taking a systems integrative approach to biology, as opposed to the reductionist gene-centric view that has dominated the field due to Neo-Darwinism. The gene-centric view has failed us in advancing progress on many diseases, and we need to now take a systems based approach focused on functional networks within biological systems. Michael Levin is an American developmental and synthetic biologist at Tufts University, where he is the Vannevar Bush Distinguished Professor. His research is focused on bioelectricity and he is my co-host for this podcast. We discuss: - DNA is not the blueprint of life - Why biology’s reductionist approach is flawed - The errors in Neo-Darwinism - Epigenetic inheritance - How to advance the cure of diseases Episode Show Notes: https://livelongerworld.com/p/dnoble Find me: https://x.com/aasthajs TIMESTAMPS: 0:00 Denis as Mike Levin’s hero 0:10 Denis’s journey to systems biology; cell voltage is a global property of the cell 3:45 Advice to young researchers pursuing systems biology 7:00 “Absolutely everything is wrong with Neo-Darwinism” 14:10 Epigenetic inheritance 19:12 Genetic vs. other information used by organisms 23:48 Biology textbooks have to expand beyond DNA in 50 years 25:03 Epigenetic processes are ubiquitous 28:58 If not DNA, what is the blueprint of life 36:15 Rewriting biology textbooks is fundamental 39:57 “A lot of time has been wasted” (in biology) 46:52 Darwin on the “Origin of Species” 55:38 “Unfortunate that Philosophy and science have diverged” 1:00:31 Importance of Functional networks; DNA does not predict disease AASTHA, LIVE LONGER WORLD: Twitter: https://x.com/aasthajs Newsletter: https://livelongerworld.com/ Instagram: https://www.instagram.com/aasthajs/ LINKS: Michael Levin: https://twitter.com/drmichaellevin Denis's book Dance to the Tune of Life: https://a.co/d/3hvh5JW Episode Show Notes: https://livelongerworld.com/p/dnoble Michael Levin on Bioelectric Signals for Longevity: https://youtu.be/XboYI_wxDr8?si=WrQ_iI8ABbG6eibm