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Evidence Based Hair

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Rating
★★★★★
4.5
from
13 reviews
This podcast has
82 episodes
Language
English
Explicit
No
Date created
2022/02/05
Latest episode
2026/10/15
Average duration
21 min.
Release period
61 days

Description

Evidence based hair is a weekly podcast hosted by Dr Jeff Donovan, a Canadian dermatologist and hair specialist. Each week, Dr. Donovan highlights recently published hair loss research from around the world.

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Check latest episodes from Evidence Based Hair podcast


Season 9, Episode 2 Reflections on Hair Loss Associated with GLP-1 Drugs
2026/10/15
Welcome to the Evidence-Based Hair Podcast, hosted by Dr. Jeff Donovan, a   dermatologist and hair loss specialist. In this episode, Dr. Donovan explores the growing concern about hair loss associated with GLP-1–based medications, including semaglutide and tirzepatide. As these medications are increasingly used for diabetes and weight management, more patients are asking whether drugs such as Ozempic, Wegovy, Mounjaro and Zepbound can cause hair loss. Dr. Donovan reviews the latest evidence from randomized clinical trials, observational studies and pharmacovigilance databases to examine how often hair loss occurs and whether the risk differs among medications. He discusses the important distinction between telogen effluvium, androgenetic alopecia and other forms of hair loss, and explains why rapid weight loss, reduced calorie and protein intake, nutritional deficiencies and the underlying effects of the medications themselves all need to be considered. The episode also examines whether faster or greater weight loss increases the risk of shedding, whether GLP-1 medications may simply uncover pre-existing patterned hair loss, and what clinicians and patients can do when hair loss develops. Dr. Donovan concludes with practical take-home messages about evaluating and managing hair loss while continuing to balance the substantial health benefits these medications can provide.   HELPFUL REFERENCES Cheng PL, Chang HC. Glucagon-like peptide-1 receptor agonists and hair loss: a systematic review and meta-analysis. Diabetes Res Clin Pract. 2026;237:113333. doi:10.1016/j.diabres.2026.113333. Tang H, Zhang B, Lu Y, Zhang D, Liu R, Lu Y, et al. Risk of hair loss associated with glucagon-like peptide-1 receptor agonists in adults with type 2 diabetes: target trial emulation. BMJ. 2026;394:e100077. doi:10.1136/bmj-2026-100077. Neubauer Z, Ong MM, Singal A, Lipner SR. Increased risk of telogen effluvium with tirzepatide compared to other weight loss medications: a retrospective cohort TriNetX database study. J Am Acad Dermatol. 2025;93(6):1612-1614. doi:10.1016/j.jaad.2025.08.033. Singal A, Ong MM, Neubauer Z, Lipner SR. Association between androgenetic alopecia and glucagon-like peptide-1 receptor treatment in type 2 diabetes mellitus patients: a retrospective cohort study. Int J Dermatol. 2025;64(11):2157-2159. doi:10.1111/ijd.17971. Godfrey H, Leibovit-Reiben Z, Jedlowski P, Thiede R. Alopecia associated with the use of semaglutide and tirzepatide: a disproportionality analysis using the FDA Adverse Event Reporting System from 2022 to 2023. J Eur Acad Dermatol Venereol. 2025;39:e153-e154. doi:10.1111/jdv.20197. Branyiczky MK, Lowe MS, McMullen E, Donovan J, Khosravi-Hafshejani T. Effects of GLP-1 receptor agonists on hair loss and regrowth: a systematic review. Int J Dermatol. 2026;65(5):1030-1032. doi:10.1111/ijd.70133. Jastreboff AM, Aronne LJ, Ahmad NN, Wharton S, Connery L, Alves B, et al. Tirzepatide once weekly for the treatment of obesity. N Engl J Med. 2022;387:205-216. doi:10.1056/NEJMoa2206038. Cote MF, Oza VS, Orlow SJ. Are pediatric GLP-1 receptor agonist cutaneous adverse events being overlooked? Emerging age-specific patterns and their implications for dermatologists. Pediatr Dermatol. 2026:1-6. doi:10.1111/pde.70340. Bridges AG, Jackson T. Hair and scalp effects of GLP-1 receptor agonists in practice. Clin Dermatol. 2026. doi:10.1016/j.clindermatol.2026.09.017. Piraccini BM, Vañó-Galván S, Blume-Peytavi U, Ribet V, Mengeaud V. Hair loss in patients on glucagon-like peptide 1 receptor agonists: understanding risks and managing outcomes. Dermatol Ther (Heidelb). 2026;16:3345-3360. doi:10.1007/s13555-026-01792-0.
Season 9, Episode 1 Reflections on Frontal Fibrosing Alopecia
2026/09/01
Welcome to the Evidence-Based Hair Podcast, hosted by Dr. Jeff Donovan, a leading dermatologist and hair loss specialist. In this episode, Dr. Donovan takes a deep dive into frontal fibrosing alopecia (FFA), one of the most fascinating and challenging conditions in modern hair medicine. First described only a few decades ago, FFA has rapidly become one of the most common forms of scarring alopecia seen in hair clinics around the world. Dr. Donovan explores what we have learned about FFA, including who develops it, why hair follicles are permanently lost, the role of genetics and the immune system, and the growing evidence that environmental factors may contribute to the disease. He also examines some of the most important recent discoveries that are changing how researchers think about FFA. The episode tackles the major controversies surrounding the condition. Are sunscreens or facial products involved? Is FFA truly an autoimmune disease? Why do medications such as dutasteride and finasteride appear to help? And how should physicians determine whether treatment is actually working? Along the way, Dr. Donovan separates what the evidence supports from what remains uncertain and explains why earlier recognition and careful monitoring are so important in this permanent form of hair loss.   HELPFUL REFERENCES Krzesłowska WJ, Woźniacka A. The frontal fibrosing alopecia treatment dilemma. J Clin Med. 2024;13(7):2137. Ezzat RZ, Alenezi S, Miteva M. Frontal fibrosing alopecia part II: etiopathogenesis and management. J Am Acad Dermatol. 2026;94(4):1075–85. Verma S, Marak A, Paul D. Frontal fibrosing alopecia: a comprehensive review with recent updates. Indian J Dermatol. 2025;70:115. Alenezi S, Ezzat RZ, Miteva M. Frontal fibrosing alopecia part I: diagnosis and clinical presentation. J Am Acad Dermatol. 2026;94(4):1059–72. Bai JQA, Gupta S, Donovan J. Frontal fibrosing alopecia in males: a systematic review. JAAD Rev. 2025;6:66-68. doi:10.1016/j.jdrv.2025.08.002. Landau M, Perez SM, Tosti A. Frontal fibrosing alopecia: a comprehensive guide for cosmetic dermatologists. Dermatol Ther (Heidelb). 2025;15(1):15–29. Messenger AG, Asfour L, Harries M. Frontal fibrosing alopecia: an update. Am J Clin Dermatol. 2025;26(2):155–74.
Season 8, Episode 11 Exploring the Link Between Alopecia Areata and Cardiovascular Disease
2024/12/23
Welcome to the final episode of the Evidence-Based Hair Podcast for 2024, hosted by Dr. Jeff Donovan, a leading dermatologist and hair loss specialist. In this episode, Dr. Donovan dives into the complex relationship between alopecia areata and cardiovascular risk, exploring recent studies that offer conflicting conclusions. Dr. Donovan reviews a notable study published in JAD International, which leverages the All of Us Research Program database to investigate whether alopecia areata patients are at increased risk for cardiovascular diseases. The study reveals intriguing findings, suggesting a potential link with chronic kidney disease and hyperlipidemia, but not with heart disease. As the podcast unfolds, Dr. Donovan discusses the broader implications of these findings, the need for long-term studies, and the ongoing debate in the medical community. He also invites listeners to a special event celebrating the top 20 studies of 2024. Join Dr. Donovan as he navigates through the complexities of hair loss research, empowering practitioners and patients alike with evidence-based insights. For more information on the Donovan Hair Academy's programs, visit their website.     STUDIES REFERENCED IN THIS EPISODE Ambika Nohria, Jill T Shah, Deesha Desai, Lina Alhanshali, Jenne Ingrassia, Alisa Femia, Michael Garshick, Jerry Shapiro, Kristen I Lo Sicco. Alopecia areata and cardiovascular comorbidities: A cross-sectional analysis of the All of Us research program. JAAD Int. 2024 Apr 8:16:46-48. doi: 10.1016/j.jdin.2024.03.024. eCollection 2024 Sep.   Lee et al. Alopecia areata is not a risk factor for heart diseases: A 10-year retrospective cohort study. PLoS One. 2021. Conic RRZ et al. Prevalence of cardiac and metabolic diseases among patients with alopecia areata. JEADV 2021
Season 8, Episode 10. Unveiling New Treatments for Dissecting Cellulitis: A Closer Look at Upadacitinib
2024/12/16
Welcome to the Evidence-Based Hair Podcast, hosted by dermatologist and hair loss specialist Dr. Jeff Donovan. In this episode, Dr. Donovan explores a groundbreaking study published in the journal Curious, highlighting the effectiveness of the JAK1 inhibitor, upadacitinib, in treating recalcitrant dissecting cellulitis of the scalp. Dissecting cellulitis, a challenging form of scarring alopecia, often affects males and presents with debilitating symptoms. While traditional treatments like isotretinoin and antibiotics offer relief for some, they aren't always effective. The study discusses a case where upadacitinib brought significant improvement after conventional options were exhausted. Dr. Donovan provides a comprehensive overview of the study, emphasizing the potential of JAK inhibitors as third-line treatments in managing persistent dissecting cellulitis. He also shares insights on the broader implications for future research and treatment strategies. Join Dr. Donovan next week for an analysis of a study on alopecia areata and cardiovascular comorbidities, and don't miss the annual "Top 20 of 2024" event on December 30th. For more information about the Donovan Hair Academy's programs, visit their website.     STUDY REFERENCED IN THIS EPISODE Zahidul Islam, Michelle Toker, Isha M Gandhi, Ariel Sher, Kristina Campto. Improvement of Recalcitrant Dissecting Cellulitis of the Scalp After a Trial of Upadacitinib. Cureus . 2024 Jan 16;16(1):e52377. doi: 10.7759/cureus.52377. eCollection 2024 Jan.
Season 8, Episode 9: Dupilumab: A Promising Treatment for Pediatric Alopecia Areata
2024/12/09
Welcome to the latest episode of the Evidence-Based Hair Podcast, hosted by dermatologist and hair loss specialist Dr. Jeff Donovan. In this episode, we delve into an intriguing study titled "Dupilumab Induces Hair Regrowth in Pediatric Alopecia Areata," which explores the potential of dupilumab as a treatment for children suffering from both alopecia areata and atopic dermatitis. Dr. Donovan discusses the study's findings, highlighting how dupilumab has shown promise in improving hair growth in this unique patient population. With a good safety profile, dupilumab emerges as a viable option alongside JAK inhibitors for managing these conditions. The episode also covers the study's methodology and results, emphasizing the significant reduction in SALT scores among the participants. Join Dr. Donovan as he shares insights into the complexities of treating pediatric alopecia areata and the potential of dupilumab to offer new hope for patients and clinicians alike. Stay tuned for the next episode, where we'll explore the use of upadacitinib in managing dissecting cellulitis.     STUDY REFERENCED IN THIS EPISODE Eden David, Neda Shokrian, Ester Del Duca, Marguerite Meariman, Jacob Glickman, Sabrina Ghalili, Seungyeon Jung, Kathryn Tan, Benjamin Ungar, Emma Guttman-Yassky. Dupilumab induces hair regrowth in pediatric alopecia areata: a real-world, single-center observational study. Arch Dermatol Res . 2024 Jul 23;316(7):487. doi: 10.1007/s00403-024-03225-4.
Season 8, Episode 8: Exploring Topical Metformin for Treating CCCA
2024/12/02
Welcome to the latest episode of the Evidence-Based Hair Podcast, hosted by dermatologist and hair loss specialist, Dr. Jeff Donovan. As the director of the Donovan Hair Academy, Dr. Donovan is committed to educating both the public and practitioners about hair loss through comprehensive training programs. In this episode, Dr. Donovan dives into an intriguing study published in the International Journal of Dermatology, which examines the use of topical metformin 10% cream in treating Central Centrifugal Cicatricial Alopecia (CCCA). This scarring alopecia primarily affects Black women and is often underdiagnosed. The study highlights a case where topical metformin showed promise in hair regrowth for a patient unresponsive to traditional treatments. Dr. Donovan discusses the potential of topical metformin as a second-line treatment option alongside oral metformin, PRP, and JAK inhibitors, while emphasizing the importance of first-line treatments such as steroid injections and topical steroids. He also addresses the challenges of compounding metformin in various formulations, which can affect its efficacy. Stay tuned for next week's episode, where Dr. Donovan will explore new research on alopecia areata and dupilumab. Join us as we continue to unravel the complexities of hair loss and discover innovative treatments that could benefit patients worldwide.   STUDY REFERENCED IN THIS EPISODE   Bárbara Vieira Granja et al. Treatment of central centrifugal cicatricial alopecia with topical metformin 10% cream: case report and literature review. Int J Dermatol . 2024 Jun 23. doi: 10.1111/ijd.17345. Online ahead of print
Season 8 Episode 7: Exploring Oral Metformin's Role in Treating CCCA
2024/11/25
Welcome to the Evidence-Based Hair Podcast, hosted by dermatologist and hair loss specialist Dr. Jeff Donovan. As the director of the Donovan Hair Academy, Dr. Donovan is dedicated to educating the public and training practitioners in the complex field of hair loss. In this episode, Dr. Donovan delves into a fascinating study from JAMA Dermatology that examines the effects of low-dose metformin on Central Centrifugal Cicatricial Alopecia (CCCA). The study reveals intriguing changes in gene expression that could offer new insights into treating this underdiagnosed condition, primarily affecting black women. Despite the study's small size and retrospective nature, the findings highlight metformin's potential role in modifying pathways related to scarring alopecia and hair growth. Dr. Donovan emphasizes the need for further research to understand metformin's efficacy and optimal dosing for CCCA patients. Join us next week as Dr. Donovan discusses the use of metformin cream in CCCA, continuing the exploration of innovative treatments in hair loss management. Stay informed and empowered to engage in meaningful discussions with hair loss practitioners.     STUDY REFERENCED IN THIS EPISODE Aaron Bao et al. Low-Dose Metformin and Profibrotic Signature in Central Centrifugal Cicatricial Alopecia. JAMA Dermatol . 2024 Sep 4:e243062. doi: 10.1001/jamadermatol.2024.3062. Online ahead of print.
Season 8 Episode 6: Uncovering the Link Between Weight Loss Medications and Hair Loss
2024/11/18
Welcome to the latest episode of the Evidence-Based Hair Podcast, hosted by Dr. Jeff Donovan, dermatologist and hair loss specialist. In this episode, Dr. Donovan delves into a fascinating study published in the Journal of the American Academy of Dermatology and Venereology, which explores the potential association between hair loss and the use of popular weight loss medications, such as semaglutide and terzepatide. Dr. Donovan discusses the methodology and findings of the study, which utilized the FDA Adverse Event Reporting System to analyze reports of alopecia linked to these drugs. The episode highlights the importance of post-marketing research in uncovering side effects not initially apparent in clinical trials. Join Dr. Donovan as he explains the statistical technique of disproportionality analysis used in the study, and its implications for understanding the potential hair loss risks associated with these medications. The episode also emphasizes the need for further research to better understand the timing, mechanism, and prevalence of hair loss among different patient groups. Stay tuned for next week's episode, where Dr. Donovan will explore the effects of metformin on central centrifugal cicatricial alopecia, based on a recent study in JAMA Dermatology. Thank you for tuning in and supporting the Evidence-Based Hair Podcast, dedicated to advancing education and research in the complex world of hair loss.   STUDIES REFERENCED IN THIS EPISODE   Hannah Godfrey, Zachary Leibovit-Reiben, Patrick Jedlowski, Rebecca Thiede. Alopecia associated with the use of semaglutide and tirzepatide: A disproportionality analysis using the FDA adverse event reporting system (FAERS) from 2022 to 2023. J Eur Acad Dermatol Venereol . 2024 Jun 24. doi: 10.1111/jdv.20197. Online ahead of print.
Season 8 Episode 5: The Role of Terzepatide in Treating AGA
2024/11/11
Welcome to the latest episode of the Evidence-Based Hair Podcast, hosted by dermatologist and hair loss specialist, Dr. Jeff Donovan. As the director of the Donovan Hair Academy, Dr. Donovan is dedicated to educating both the public and hair loss practitioners about the complexities of hair loss. In this episode, Dr. Donovan delves into a fascinating study from JAAD Case Reports, which explores the potential benefits of the diabetes drug terzepatide for treating androgenetic alopecia. This groundbreaking case report suggests that medications targeting insulin resistance could offer new strategies for hair growth. Join Dr. Donovan as he breaks down the study, discusses the implications of using GLP-1/GIP receptor agonists for hair loss, and highlights the importance of understanding the metabolic connections to androgenetic alopecia. Discover how these findings could pave the way for novel treatment approaches and what it means for patients worldwide. Whether you're a practitioner, researcher, or someone affected by hair loss, this episode provides insightful perspectives on the future of hair loss treatment. Tune in to learn more about the potential of terzepatide and similar medications in addressing hair loss challenges.     STUDY REFERENCED Gordon E, Musleh S,  Bordone LA. Treatment of insulin resistance with tirzepatide leading to improvement of hair loss. JAAD Case Rep . 2024 Jun 11:50:123-125. doi: 10.1016/j.jdcr.2024.06.001. eCollection 2024 Aug.
Season 8, Episode 4: Unveiling the Risks: Steroid Injections and Vision Complications in Hair Loss Treatment
2024/10/28
Welcome to the Evidence-Based Hair Podcast, hosted by dermatologist and hair loss specialist, Dr. Jeff Donovan. In this episode, we delve into a crucial study exploring the unexpected side effects of steroid injections used in treating alopecia areata, particularly focusing on central serous chorioretinopathy (CSC). This condition, characterized by fluid accumulation beneath the retina, can lead to vision problems and retinal detachment. Dr. Donovan reviews a compelling paper published in JAAD Case Reports, highlighting two cases where patients developed CSC after receiving steroid injections for hair loss. The episode emphasizes the importance of recognizing blurry vision as a potential warning sign and the need for immediate consultation with an eye specialist. Join us as we discuss the implications of this study for hair loss specialists and the necessity of ongoing research to better understand the risks associated with long-term steroid use. Stay tuned for next week's episode, where we'll explore the role of tirzepatide in androgenetic hair loss treatment.   STUDIES REFERENCED IN THIS EPISODE Deesha Desai, Ambika Nohria, Lina Alhanshali, Michael Buontempo, Kristen I Lo Sicco, Craig Fern, Jerry Shapiro. Central serous chorioretinopathy after scalp and eyebrow intralesional triamcinolone acetonide injections: Report of two cases. JAAD Case Rep . 2024 Jul 14:51:86-91. doi: 10.1016/j.jdcr.2024.06.034. eCollection 2024 Sep.
Season 8, Episode 3. Understanding Alopecia Neoplastica: A Deep Dive into Hair Loss from Metastatic Breast Cancer
2024/10/21
Welcome to another insightful episode of the Evidence-Based Hair Podcast with Dr. Jeff Donovan, a dermatologist and hair loss specialist. As the director of the Donovan Hair Academy, Dr. Donovan is dedicated to educating the public and practitioners about hair loss through comprehensive training programs. In this episode, Dr. Donovan explores a fascinating study from the Brazilian Annals of Dermatology, focusing on the trichoscopic features of alopecia neoplastica caused by breast cancer metastases. Alopecia neoplastica, a type of hair loss linked to neoplastic processes, can sometimes resemble alopecia areata, but presents with distinct trichoscopic patterns. Dr. Donovan discusses the study's findings on the blood vessel patterns and color variations that are key indicators of this condition. Join us as we delve into the clinical case of a patient with metastatic breast cancer presenting with alopecia neoplastica. Discover the significance of early detection and how trichoscopy can aid in diagnosing and managing this complex form of hair loss. Tune in next week as we explore the rare side effect of central serous chorioretinopathy from steroid injections, and continue our journey of empowering clinicians and patients through education.     STUDIES REFERENCED IN THIS EPISODE   Bruno Simão Dos Santos, Eduardo César Diniz Macêdo, Bruna Nascimento Arruda Scabello, Patrícia Porto de Oliveira Grossi, Neusa Yuriko Sakai Valente. Dermoscopy of neoplastic alopecia secondary to cutaneous metastasis from breast carcinoma. An Bras Dermatol. 2024 Sep-Oct;99(5):742-745. doi: 10.1016/j.abd.
Season 8, Episode 2: Exploring Diphencyprone Use for Alopecia Areata During Pregnancy
2024/10/14
Welcome to the latest episode of the Evidence-Based Hair Podcast, hosted by dermatologist and hair loss specialist, Dr. Jeff Donovan. As the director of the Donovan Hair Academy, Dr. Donovan is committed to educating both the public and hair loss practitioners through comprehensive programs like the Evidence-Based Hair Fellowship (EBHF). In this episode, Dr. Donovan delves into a compelling case report from JAAD Case Reports that explores the use of diphencyprone (DPCP) for treating alopecia areata during pregnancy. Traditionally contraindicated in pregnancy, DPCP is a topical treatment that induces an allergic reaction on the scalp to promote hair regrowth in patients with alopecia areata. Dr. Donovan discusses a unique case where a patient opted to continue DPCP treatment during her pregnancies, resulting in minimal hair loss without any adverse effects on her pregnancies or babies. Dr. Donovan emphasizes the significance of this study in contributing to the limited data available on DPCP use during pregnancy. While the findings are promising, he cautions that more research is needed before making broad recommendations for DPCP use during pregnancy. Join Dr. Donovan next week too as he explores the trichoscopy of alopecia neoplastica from breast cancer in another enlightening episode of the Evidence-Based Hair Podcast. Don't miss this opportunity to expand your knowledge and engage in meaningful discussions about hair loss treatment and research.     STUDIES REFERENCED IN THIS EPISODE: Desai DD et al. Use of diphenylcyclopropenone for alopecia areata treatment during pregnancy. JAAD Case Rep. 2024 Apr 19:48:88-89. Berth-Jones et al. Diphencyprone is not detectable in serum or urine following topical application. Acta Derm Venerol 1994; 74: 312-3.
Season 8, Episode 1: Navigating JAK Inhibitors and Pregnancy: Insights and Implications
2024/10/07
Welcome to the Evidence-Based Hair Podcast, hosted by dermatologist and hair loss specialist Dr. Jeff Donovan. As the director of the Donovan Hair Academy, Dr. Donovan is dedicated to educating both the public and practitioners about hair loss through comprehensive training programs like the Evidence-Based Hair Fellowship. In this episode, Dr. Donovan delves into the critical topic of JAK inhibitors and their safety during pregnancy. He explores a pivotal study published in Drug Safety that examines pregnancy outcomes in patients treated with Upadacitinib, a JAK inhibitor used for various inflammatory disorders, including alopecia areata. The episode provides an in-depth analysis of data from clinical trials and post-marketing reports, highlighting the impact of JAK inhibitors on pregnancy outcomes, such as congenital anomalies and live births. Dr. Donovan discusses the importance of understanding the safety of these medications in pregnancy and emphasizes the need for more research in this area. Listeners will gain valuable insights into the complexities of managing hair loss treatments during pregnancy and the challenges faced by patients and clinicians alike. Dr. Donovan also shares promising findings and case studies involving other JAK inhibitors, offering a comprehensive overview of the current landscape and future directions in this field. Join us for this informative episode as Dr. Donovan addresses a pressing concern in the world of hair loss and pregnancy, providing expert analysis and guidance for both practitioners and patients.     REFERENCES Uma Mahadevan et al. Pregnancy Outcomes in Patients Treated with Upadacitinib: Analysis of Data from Clinical Trials and Postmarketing Reports. Drug Saf . 2024 Oct;47(10):1039-1049. doi: 10.1007/s40264-024-01454-0. Epub 2024 Jul 15.   Megan E B Clowse et al. Pregnancy Outcomes in the Tofacitinib Safety Databases for Rheumatoid Arthritis and Psoriasis. Drug Saf . 2016 Aug;39(8):755-62. doi: 10.1007/s40264-016-0431-z.   Mahadevan U et al. Outcomes of Pregnancies With Maternal/Paternal Exposure in the Tofacitinib Safety Databases for Ulcerative Colitis. Inflamm Bowel Dis. 2018 Nov 29;24(12):2494-2500. doi: 10.1093/ibd/izy160.
Season 8 Preview
2024/10/01
Welcome back to Season 8 of the Evidence-Based Hair Podcast! I'm Dr. Jeff Donovan, a dermatologist and hair loss specialist. Join me each week as I review groundbreaking studies that are transforming our understanding of hair loss and influencing clinical practices. This season, we'll delve into a variety of compelling topics including hair loss medications during pregnancy, JAK inhibitors like upadacitinib and baricitinib, and the use of terzepatide and metformin. We'll also explore conditions such as alopecia areata, androgenetic hair loss, CCCA, and dissecting cellulitis, and discuss their links to heart disease, thyroid disease, and breast cancer. Episodes will be released every Monday, and you can also find video presentations on our Donovan Medical YouTube channel. Thank you for your continued interest, and we look forward to another exciting season!
Season 7, Ep 10: Topical JAK Inhibitors: How well do they work for FFA/LPP?
2024/06/24
Welcome back to the Evidence-Based Hair Podcast! This episode continues our June theme on JAK inhibitors, focusing on their topical use for treating frontal fibrosing alopecia (FFA) and lichen planopilaris (LPP). We'll delve into a groundbreaking study by Dr. Maryanne Senna and colleagues from Boston, examining the effectiveness and side effects of topical 2% tofacitinib for FFA and LPP. The study's results provide encouraging data, showing that about 31.6% of patients experienced improvement, and 60.5% saw disease stabilization. Join us as we explore the potential of topical JAK inhibitors in managing scarring alopecia, their practical applications, and the implications for future treatment protocols. Don't miss our insightful discussion on this emerging therapy and how it could transform patient care. Next month, we'll shift gears to discuss spironolactone and its role in treating androgenetic hair loss in women. Stay tuned!   STUDIES REFERENCED IN THIS EPISODE Li-Chi Chen, Chino Ogbutor, Kristen J Kelley, Maryanne M Senna. Topical tofacitinib for patients with lichen planopilaris and/or frontal fibrosing alopecia. J Am Acad Dermatol. 2024 Jun;90(6):1260-1262. doi: 10.1016/j.jaad.2024.01.060. Epub 2024 Feb 2.   Yang C.C., Khanna T., Sallee B., Christiano A.M., Bordone L.A.: Tofacitinib for the treatment of lichen planopilaris: a case series. Dermatol Ther 2018; 31:   Moussa A., Bhoyrul B., Asfour L., Kazmi A., Eisman S., Sinclair R.D.: Treatment of lichen planopilaris with baricitinib: a retrospective study. J Am Acad Dermatol 2022; 87: pp. 663-666.   Plante J., Eason C., Snyder A., Elston D.: Tofacitinib in the treatment of lichen planopilaris: a retrospective review. J Am Acad Dermatol 2020; 83: pp. 1487-1489.

Podcast reviews

Read Evidence Based Hair podcast reviews


4.5 out of 5
13 reviews
★★★★☆
Monarchs and Meadows 2025/02/13
Helpful but…
Would love to hear more about FFA and new studies being done. There are too many people suffering from this and it is devastating all who it claims.
★★★★☆
Uzi Seraphin 2022/11/08
Really good
Great podcast but I wish you guys would focus more on aga and medical treatment since it’s the most common type of alopecia
check all reviews on apple podcasts

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