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In his first interview about Ghosts in the Blood, world-renowned hematologist/oncologist and CLL researcher Jeff Sharman, MD, takes us on a fascinating journey through the history of chronic lymphocytic leukemia—from its earliest recognition in the scientific literature in 1924 to the remarkable advances that have transformed CLL treatment. Along the way, Dr. Sharman brings the history to life with stories of the patients, physicians, scientists, rivalries, setbacks, and breakthroughs that shaped the field, revealing how discoveries in CLL helped drive the broader evolution of cancer medicine from chemotherapy to monoclonal antibodies, targeted therapies, and precision medicine. Find out more about Ghosts in the Blood. https://www.jeffsharmanmd.com/book-media-kit Check out Chadi’s website for all Healthcare Unfiltered episodes and other content. https://www.chadinabhan.com/ Watch all Healthcare Unfiltered episodes on YouTube. https://www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA

Chadi is joined by entrepreneur Dan Bickford, co-founder of Confirma and creator of the CADstream computer-aided detection software, to explore how artificial intelligence is transforming breast cancer screening with MRI. They discuss which women are most likely to benefit from breast MRI—particularly those with dense breast tissue—the evidence supporting AI-assisted interpretation as an FDA-cleared workflow tool, and how the technology complements radiologists to improve accuracy and efficiency. The conversation also examines why MRI screening is not recommended for all women with dense breasts, the practical barriers to broader adoption, and the potentially life-saving consequences of identifying the right patients for advanced imaging. Check out Chadi’s website for all Healthcare Unfiltered episodes and other content. https://www.chadinabhan.com/ Watch all Healthcare Unfiltered episodes on YouTube. https://www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA

In this new episode of Healthcare Unfiltered - Arabic Edition, Nagla and Chadi host Drs. and Professors Nevine Elabd and Mai Sherif to discuss what happens inside the medical laboratories, and how new technological advances in the laboratory, including artificial intelligence, are aiding and helping patients and the doctors that care for them. Check it out, share, subscribe, and join the conversation. في حلقة جديدة من Healthcare Unfiltered – النسخة العربية، أستضيف أنا ونجلاء الدكتورتين والأستاذتين نيفين العبد ومي شريف في حوار شيّق نأخذكم فيه إلى داخل المختبرات الطبية لنتعرّف على ما يحدث خلف الكواليس، وكيف تُسهم أحدث التطورات التكنولوجية — وعلى رأسها الذكاء الاصطناعي — في تطوير عمل المختبرات، ودعم الأطباء، وتحسين رعاية المرضى. .شاهدوا الحلقة، شاركوها مع الآخرين، اشتركوا في البرنامج، وانضموا إلى الحوار

In this deeply personal episode, Allison A. Fitzgerald, MD, PhD, a pancreatic oncologist at Dana-Farber Cancer Institute, reflects on the experience of losing her mother to cancer and the story she courageously shared in ASCO Connection. She discusses what prompted her to publish such an intimate account, the unique perspective of serving as both an oncologist and a caregiver, the emotional support that sustained her, and how her family and others in her life responded to her essay. Dr. Fitzgerald also explores the often-overlooked burden placed on caregivers, why current support systems fall short, what changes are needed to better care for those caring for others, and how this life-changing experience reshaped her understanding of balance, grief, and compassion in medicine. View the article. https://connection.asco.org/do/painful-clarity-reflections-being-oncologist-and-having-loved-one-die-cancer Check out Chadi’s website for all Healthcare Unfiltered episodes and other content. https://www.chadinabhan.com/ Watch all Healthcare Unfiltered episodes on YouTube. https://www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA

In this thought-provoking episode, Chadi Nabhan sits down with Thomas Seyfried, PhD, professor of biology at Boston College, to explore his controversial and unconventional views on cancer metabolism, the ketogenic diet, and the role of sugar in cancer development. Dr. Seyfried explains the science behind metabolic therapy, the origins of the glucose ketone index (GKI), why ketogenic diets have long been used to treat epilepsy, and his belief that restricting glucose and glutamine can prevent cancer growth, challenging the widely accepted view that cancer is primarily a genetic disease. They also discuss whether healthy individuals should follow a ketogenic diet, how his research is being received by the oncology community, and the evidence behind these bold claims in a candid, spirited conversation that is sure to spark debate. Check out Chadi’s website for all Healthcare Unfiltered episodes and other content. https://www.chadinabhan.com/ Watch all Healthcare Unfiltered episodes on YouTube. https://www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA

Neeta Somaiah, MD, of The University of Texas MD Anderson Cancer Center, provides a comprehensive overview of bone and soft tissue sarcomas, exploring how molecular classification and histology guide treatment decisions, the major therapeutic breakthroughs and drug approvals that have reshaped the field over the past decade, and current approaches to curative-intent therapy, including surgery, radiation, and adjuvant treatment strategies. The conversation also examines the management of advanced sarcoma, highlighting recent advances, ongoing challenges, and where the field is headed for patients with these complex malignancies. Check out Chadi’s website for all Healthcare Unfiltered episodes and other content. https://www.chadinabhan.com/ Watch all Healthcare Unfiltered episodes on YouTube. https://www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA

Chadi speaks with Michael Karlfeldt, ND, PhD, a board-certified naturopathic doctor, integrative medicine expert, and author of Breast Cancer Breakthrough: Integrating Conventional & Natural Medicine for True Healing, about evidence-informed complementary approaches to breast cancer care. They discuss how nutritional strategies, stress management, sleep optimization, toxin reduction, and other supportive interventions can be safely integrated alongside conventional breast cancer treatments, the inspiration behind his book, and why his protocols are designed to complement—not replace—standard oncology care. The conversation also explores the challenges of limited clinical evidence for integrative medicine, how Dr. Karlfeldt evaluates available research, and what patients, caregivers, and oncology professionals should know about incorporating supportive therapies into comprehensive breast cancer treatment. View more on the book. https://bookshop.org/p/books/breast-cancer-breakthrough-integrating-conventional-natural-medicine-for-true-healing-michael-karlfeldt/78fd09a593531461 Check out Chadi’s website for all Healthcare Unfiltered episodes and other content. https://www.chadinabhan.com/ Watch all Healthcare Unfiltered episodes on YouTube. https://www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA

Chadi Nabhan sits down with Saad Shahzad, co-founder of ZoomLogi, to explore how AI is revolutionizing healthcare logistics by improving the delivery of high-value, time-sensitive therapies, including cell and gene therapies, specialty pharmaceuticals, and biologics. They discuss the costly challenges of shipment delays, chain-of-custody issues, and fragmented supply chain systems, and how ZoomLogi's AI-powered platform provides real-time visibility across carriers, predicts disruptions before they occur, and delivers precise shipment ETAs to help ensure life-saving treatments reach patients safely and on time. Read more about ZoomLogi. https://www.zoomlogi.com/ Check out Chadi’s website for all Healthcare Unfiltered episodes and other content. https://www.chadinabhan.com/ Watch all Healthcare Unfiltered episodes on YouTube. https://www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA

On this inagural and special episode of Healthcare Unfiltered -Arabic Edition, Nagla and I host the world-renowned actor and artist, Mr. Ahmed Shaker, who candidly shares his career journey and how he almost went into medicine. Mr. Shaker who speaks 3-4 languages has risen to fame through many series that were watched by millions. He discusses with us how art can help patients and how artists can use their fame, reach, and people's trust to disseminate health information and to help people combat fake data that may be all over social media. Mr. Shaker also shares his journey as a caregiver of his wonderful mom who was affected by cancer and how he navigated the healthcare system. Mr. Shaker wants and is making a difference, and we are very grateful that he joined us on our show. Please share this show with your friends and colleagues, and don't forget to subscribe, review, and join the conversation  نستضيف أنا ونجلاء الفنان والممثل العالمي الأستاذ أحمد شاكر، الذي يشاركنا بصراحة رحلته الفنية والمهنية، وكيف كاد أن يختار دراسة الطب بدلًا من الفن. يتحدث الأستاذ شاكر، الذي يجيد ثلاث إلى أربع لغات وحقق شهرة واسعة من خلال العديد من المسلسلات التي تابعها الملايين، عن الدور الذي يمكن أن يلعبه الفن في مساعدة المرضى، وكيف يستطيع الفنانون توظيف شهرتهم وتأثيرهم وثقة الجمهور بهم لنشر المعلومات الصحية الموثوقة والمساهمة في مواجهة المعلومات المضللة المنتشرة عبر وسائل التواصل الاجتماعي. كما يشاركنا تجربته الشخصية كمرافق ومساند لوالدته الرائعة خلال إصابتها بالسرطان، وما تعلمه من رحلته معها في التعامل مع منظومة الرعاية الصحية. الأستاذ أحمد شاكر حريص على إحداث فرق حقيقي، وهو بالفعل يفعل ذلك، ونحن ممتنون جدًا لانضمامه إلينا في هذه الحلقة المميزة.

World-renowned MPN expert Dr. Prithviraj Bose of MD Anderson Cancer Center joins Chadi to explore the latest advances in myeloproliferative neoplasms (MPNs), including the molecular drivers of polycythemia vera, essential thrombocythemia, and myelofibrosis, and how these discoveries are reshaping patient care. The conversation then turns to the landmark phase 3 SENTRY trial, which evaluated frontline selinexor plus ruxolitinib versus ruxolitinib alone for patients with JAK inhibitor–naïve myelofibrosis—a rare blood cancer characterized by bone marrow scarring, splenomegaly, and debilitating symptoms. Dr. Bose discusses the trial's potentially practice-changing results, the benefits and limitations of the combination regimen, and what the data mean for the future standard of care in myelofibrosis. Check out Chadi’s website for all Healthcare Unfiltered episodes and other content. https://www.chadinabhan.com/ Watch all Healthcare Unfiltered episodes on YouTube. https://www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA

Chadi is joined by two of the world's leading multiple myeloma experts, Dr. Sagar Lonial of Emory University and Dr. Vincent Rajkumar of Mayo Clinic, for an in-depth discussion of the latest advances in multiple myeloma presented at the European Hematology Association (EHA) Congress in Stockholm. They explore the emerging class of cereblon E3 ligase modulators (CELMoDs), explaining how these next-generation therapies differ from existing immunomodulatory drugs, the science behind their mechanism of action, and why they are generating so much excitement in the field. The conversation also reviews the key clinical trial data unveiled at EHA, discusses where CELMoDs may fit into the evolving treatment landscape, and looks ahead to the breakthroughs that could shape multiple myeloma care in the years to come. Check out Chadi’s website for all Healthcare Unfiltered episodes and other content. https://www.chadinabhan.com/ Watch all Healthcare Unfiltered episodes on YouTube. https://www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA

How is decision-making shaped in hematology? In a setting where evidence from randomized clinical trials, real-world data, and the uncertainties inherent in everyday clinical practice coexist, how do we analyze the available information to make the best treatment decisions for our patients? Cómo se construye la toma de decisiones en hematología? En un escenario donde conviven la evidencia de los estudios clínicos aleatorizados, los datos del mundo real y las incertidumbres inherentes a la práctica diaria, cómo analizamos la información disponible para tomar las mejores decisiones terapéuticas para nuestros pacientes?

Advanced Practice Providers (APPs)—including physician assistants (PAs) and nurse practitioners (NPs)—are playing an increasingly vital role in meeting the growing demand for high-quality cancer care. Corinne Shamehdi, PA-C, a hematology/oncology physician assistant and educator with NCODA, sits down with Chadi and discusses why the APP workforce is expanding, how PAs and NPs are trained, the evolving relationship between APPs and physicians, and addresses common misconceptions surrounding their role in oncology practice. The conversation also explores licensure across state lines, career advancement opportunities, and how oncology APPs stay current with the rapid pace of new cancer therapies and clinical evidence, offering an inside look at one of the fastest-growing segments of the oncology workforce. NCODA is a non-profit organization that supports the full oncology care team through education, quality standards, and best practices. If you're an Oncology APP or a member of the oncology care team, you can learn more and join NCODA. Membership is complimentary. Join here: https://bit.ly/NCODAHealthcareUnfiltered Find out more about NCODA. https://ncoda.org/ Check out Chadi’s website for all Healthcare Unfiltered episodes and other content. https://www.chadinabhan.com/ Watch all Healthcare Unfiltered episodes on YouTube. https://www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA

Cardiologist and “The Doctor's Lounge” host Anish Koka, MD, joins the show to examine the extraordinary ChemoCentryx and Tavneos (avacopan) controversy, including the retraction of a New England Journal of Medicine clinical trial that played a key role in the drug's FDA approval for ANCA-associated vasculitis. Based on his Substack investigation, Dr. Koka breaks down the timeline of events, the concerns surrounding post hoc changes to trial endpoints, the FDA's response, and the far-reaching implications for clinical trial integrity, drug development, pharmaceutical regulation, and evidence-based medicine. Tune in for a thought-provoking discussion on scientific transparency, regulatory oversight, and what this high-profile case means for physicians, researchers, the pharmaceutical industry, and patients alike. Read the substack article. https://anishkokamd.substack.com/p/we-cannot-afford-to-miss-a-superiority Subscribe to The Doctor's Lounge. https://podcasts.apple.com/us/podcast/the-doctors-lounge/id1832097658 Check out Chadi’s website for all Healthcare Unfiltered episodes and other content. https://www.chadinabhan.com/ Watch all Healthcare Unfiltered episodes on YouTube. https://www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA

In this special episode, Chadi sits down with one of the most influential figures in modern leukemia research and care: Hagop M. Kantarjian, MD, Professor and Samsung Distinguished Leukemia Chair in Cancer Medicine at The University of Texas MD Anderson Cancer Center. Dr. Kantarjian reflects on four decades of progress in leukemia treatment, discussing how the field has evolved from an era of limited therapeutic options to one transformed by groundbreaking scientific advances, while offering his perspective on risk stratification across favorable, less favorable, and high-risk leukemias. The conversation spans chronic myeloid leukemia (CML), chronic lymphocytic leukemia (CLL), acute lymphoblastic leukemia (ALL), and acute myeloid leukemia (AML), including the promise of triplet and quadruplet regimens and the urgent need for better therapies in secondary leukemias. Combining historical perspective, clinical insight, and a vision for the future, this episode is a rare opportunity to hear from a physician-scientist whose work has helped shape the modern treatment landscape for patients with leukemia worldwide. Check out Chadi’s website for all Healthcare Unfiltered episodes and other content. https://www.chadinabhan.com/ Watch all Healthcare Unfiltered episodes on YouTube. https://www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA