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Send us Fan Mail Summary:  Though there are many musculoskeletal topical pain products on the market, the strength of evidence for their effectiveness is often lacking.  This discussion covers the basic ingredients, how they work, and what is the evidence for their effectiveness.     Topics: ·       Musculoskeletal Pain 01:30 ·       OTC Topicals Low-Risk 02:00 ·       Capsaicin 02:30 ·       NSAIDS (Diclofenac) 04:00 ·       Lidocaine 4% 05:15 ·       Menthol 07:40 ·       Cabbage Leaf Wrap 08:30 ·       Strength of Recommendation (evidence) 10:15 ·       RICE 13:00 ·       Other Options 15:00 Questions and comments to  [email protected]

Send us Fan Mail   Summary:  Who hasn’t had a rash?  This episode looks at the available steroid creams (Corticosteroids – not anabolic), broken down by their potency and possible indications for use.  And as with every other medication on the market, there are potential side effects, which mandates the Risk-Benefit discussion.  Knowing the trigger, which may include stress, for the rash and the proper use of a topical steroid treatment is the road to the best treatment.  A reminder:  just because it’s a topical treatment doesn’t mean it’s not a potent medication. Topics: ·       OTC Hydrocortisone Cream & Ointment 01:30 ·       Occlusives 02:30 ·       Mechanism of Action 03:20 -              Reduce inflammation -              Suppress immune response -              Reduce cell turnover -              Constrict blood vessels ·       7 Classes of Topical Steroid Potency 06:00 ·       Where are You on the continuum? 07:00 ·       Indications 10:00 ·       Risk-Benefit (side effects) 13:00   Questions and comments to  [email protected]

Send us Fan Mail     Summary: This podcast addresses the overlap seen in depression and psychosis, and how the second generation antipsychotic meds have expanding FDA-approved indications.      Topics: ·       This little light of mine 01:10 ·       Advertising through you 02:20 ·       Dopamine 04:00 ·       Homeostasis-Balance 04:50 ·       Participate & Communicate 07:00 ·       Decreased Dopamine 08:15 -       Parkinsons -       Restless Leg Syndrome ·       Dopamine Receptors ·       Increased Dopamine 12:00 -       Schizophrenia ·       1st and 2nd Generation Antipsychotics 14:00 ·       Side Effects 14:40 ·       Risk-Benefit 15:20 ·       Extrapyramidal Symptoms 16:15 ·       Relapse decrease with Caplyta 17:30 ·       Internet Gaming Disorder 20:00 ·       Caplyte 25:15 ·       5 Steps of Drug Development 28:00   Questions and comments to  [email protected]

Send us Fan Mail Summary:  The right medication at the right dose at the right time, with the patient actively participating in that choice, may provide an incredible benefit.  But there are many ways to change your chemistry, amongst them being laughter and music, two essential ingredients of a good party.  Genuine Laughter stimulates your heart, lungs and muscles while also increasing the endorphins in your brain.  Stress is also diminished.  And so it goes for the right music, the long-term effects including improved immune system, pain relief, and lessened stress, depression and anxiety.  Whether meds are included in your regimen or not, adding a good-hearted laugh and the right music to your day generally carries wonderful benefits and very little risk.    Topics:   ·       Bag of Chemicals? 02:00 ·       Music Categories & Effects 03:00 ·       Risks 04:00 ·       Science & Studies (Music & Mind/Body) 05:10 ·       Laughter & Mood/CV Benefits 06:00 ·       Thalmocortical dysrhythmia — a disorientation of rhythmic brain activity involving the thalamus and the outer cortex  Parkinson's, fibromyalgia and possibly even Alzheimer's  *      Vibroacoustic therapy. 06:30 ·       Drumming Circles 07:10 ·       Post-Natal Depression (singing with baby) 07:50 ·       Medically Compounded Songs – for Seizures/Parkinsons/Depression? 13:40 ·       Contraindicated Music & Songs 14:50 ·       Music & Colors & Moods 16:20 ·       Too Much of one Style? 16:50 ·       AI Data Centers’ Hum – Disrupting Nature, and us? 17:30 Questions and comments to  [email protected]

Send us Fan Mail Summary:  Politics and opinion in healthcare is full of bias, which obscures objective truth.  This podcast calls for calm, evidence based medicine, following the most reliable data.  And as usual, a reminder for the patient to participate in their care, sharing in decision making with their healthcare team.    Topics: ·      Keep Medicine out of Politics 01:50 ·      Bias = Opinion 02:45 ·      Mental Health Crisis 03:30 ·      Prevalence 04:00 ·      Housing Instability 05:00 ·      Overuse of Psychiatric Medications 07:15 ·      Cause of Mental Health Crisis 09:45 ·      Heavy Social Media Use 11:45 ·      Participate in Your Care 13:00 ·      Heroin and SSRI’s 14:50 ·      Addiction vs. Dependence (there is a difference) 17:15 ·      Brain Chemistry 20:00 ·      SSRI Mechanism of Action 21:30 ·      Bias…Keep it out of science 22:00 ·      Vaccines 24:50 ·      Side Effects of SSRI’s 26:00 ·      Withdrawal symptoms of SSRI’s 30:00 ·      No Name Calling 31:30 ·      More Keeping Politics out of science Previous Podcast about Rescheduling and Legalizing Marijuana 32:00     Questions and comments to  [email protected]

Send us Fan Mail Summary:  Laughter:  don’t take it too seriously.  Topics: ·       Benefits of Laughter 02:00 ·       Ranting & Raving 06:00 ·       Leaf Blowers 07:45 ·       AI Recommendations 08:45 ·       Meditation – Mindfulness-Laughter 10:10         (Changing Your Chemistry) ·       Short-term Benefits = stimulate heart, lungs & muscles 11:00 -              Increase endorphins -              Relieve stress ·       Long-term Benefits = improve immune system 11:30 -              Decrease anxiety ·       Negative Effects of Laughter 12:00 ·       Connect 14:00 ·       A Bag of Chemicals 14:30 ·       A Survival Tool 15:30 ·       “Don’t take it too seriously.” 17:30     Questions and comments to  [email protected]

Send us Fan Mail Summary:  This episode is about taking a toxin, isolating it, purifying it and then injecting it into your face; or other parts of your body.  Safe use of botulism toxin A relies upon its local activity.  The indications include cosmetic smoothing, excessive sweating, eye disorders, chronic migraines, and overactive bladder.  Assessing the Benefit-Risk of Botox is also discussed, along with the need for close monitoring. Topics: ·       Botulism Toxin A 01:30 ·       Premarin 02:15 ·       Exotoxin & Endotoxin 03:00 ·       Biological Warfare 03:30 ·       Indications -              Cosmetic -              Severe Sweating -              Cervical Dystonia -              Blepharospasm -              Strabismus -              Chronic Migraine -              Overactive Bladder ·       History of Botox 05:50 ·       Mechanism of Action 06:20 ·       Benefit-Risk 08:30 ·       Local Effect 10:30 ·       Side Effect Rare 13:00 ·       Iatrogenic Bolulism ·       Monitor – Journal 13:30 Questions and comments to  [email protected]

Send us Fan Mail Summary:  Journavx was born of the search for an option to opioids for moderate to severe pain relief.  The early results are mixed, some claiming it to be a miracle drug, others dismayed with its lack of effectiveness and its side effects.  Since Journavx utilizes a novel (non-opioid) approach to severe pain relief, the drug was fast-tracked by the FDA, which is a process used to facilitate the development and expedite the review of drugs which provide unmet medical needs, and thereby provide faster access for patients.  Post marketing review is essential to fully defining this drug’s benefits and risks.   Topics:  ·       Opioid Crisis  01:00 ·       JOURNAVX – Moderate to Severe Acute Pain 01:30 ·        Mechanism of Action – New!  02:00 ·       FDA Fast Track – Novel Approach 03:30 ·       Acute Pain = 14 Dayn Approval 05:00 ·       Side Effects:  Nausea, Constipation, Headache         Dizziness, Itching, Muscle Spasm. 05:30 ·       Further Studies Needed…07:00 ·       Precautions:  Liver Function and Drug Interactions 08:00 ·       Dosing. 09:00 ·       New Approach  Post Marketing Monitoring 11:00 ·       Shared Anecdotal Reports 11:30 ·       MedWatch – FDA 12:15 ·       Journaling 14:00 ·       Cause & Effect 14:30 ·       Follow-Up! 15:00 Questions and comments to  [email protected]

Send us Fan Mail  Summary:  Panic attacks are real and more common than you might think.  This is a discussion of the possible causes of panic attacks and when a panic attack becomes part of a panic disorder.  Psychotherapy and medications, both first-line treatments, are considered here.  The importance of compassion is essential:  be kind to yourself and others.     Topics: ·       Panic Attack Symptoms 02:15 ·       Panic Disorder 04:15 ·       Rule Out Medical Issues and Toxicities ·       Incidence 07:30 ·       Causes?  09:00 ·       Compassion 10:15 ·       Psychotherapy 13:30 ·       Medications -              Benzodiazepines – Xanax -              SSRI = Zoloft/Paxil/Prozac -              SNRI = Effexor -              TCA = Imipramine -              Beta-Blockers = Propranolol ·       Monitor Treatments (Journal) – be patient 18:00 ·       Be Kind to Yourself and Others 18:50 ·       988   Questions and comments to  [email protected]

Send us Fan Mail Summary:  This podcase provides a review of GLP-1 medications, from describing what they are, how and where the work in the body, and emerging new uses for this class of drug.  The potential benefits of the GLP-1 drugs, coupled with their high cost, have spawned the compounding of these meds, raising legal and safety questions about this process.  Even with the excitement of what these meds might provide, working with your physician and your healthcare team to ensure the safety and efficacy of the medications, and monitoring your treatment, is essential.   Topics:   Shared decision-making 01:00 Incretin Mimetics 01:40 Byetta 2005 03:00 Side Effects Become Indications 04:00                   GLP = Weight Loss                   Minoxidil = Hair Growth                   Valproate = Mania tx                   Sildenafil = ED GLP-1 Kinetics 07:15 Hormones 09:30 Microdosing 12;00 GLP-1 Receptors 17:00 Exploring other GLP-1 Indications 18:15 GLP Anti-inflammatory Effects 23:30 More Research Needed to Provide Definitive Answers 24:00                   NAFLD/Parkinsons/Alzheimers/Osteoarthritis/Chemical Dependency Maintenance Med?  28:00 Monitor & Work with Healthcare Tea 28:00     Questions and comments to  [email protected]

Send us Fan Mail Summary:  An epidemic of Isolation and Loneliness?  Recent studies have found this to be true, and the subsequent effects upon the mental and physical health of the isolated & lonely person are significant.  They include an increased risk of dementia, heart disease, stroke, diabetes type II, obesity, depression and anxiety and the risks of the medications used to treat these ailments.  These are potential physical and mental challenges for the person, in addition to the painful experience of isolation, wherein there is a lack of contact and support from others, and loneliness, wherein there is the subjective feeling of not having close meaningful relationships or a sense of belonging.  We’ve all been there.  The idea here is to think about helping yourself - and others - to connect  Topics: ·       Surgeon General 2023 Epidemic of Isolation & Loneliness 02:00 ·       Isolation & Loneliness Defined ·       Incidence of Loneliness by age 05:15 ·       “Say Hello in There” 06:10 ·       Existential Loneliness 09:00 ·       Health Risks of Isolation & Loneliness 11:00         Heart Disease 29%         Strokes 32%         Dementia 50%          Also increase incidence of Depression & Anxiety, Obesity, Diabetes Type II ·       Risks & Causes of Isolation & Loneliness 14:00 ·       Technology (AI) 16:45 ·       Additional Meds d/t possible health risks of Loneliness/Isolation 22:45 ·       Drug for Loneliness?  23:15 ·       988 Suicide and Crisis Lifeline 25:00 ·       Talk with Your MD 27:00 ·       If you are feeling alone, you are not alone in this Questions and comments to  [email protected]

Send us Fan Mail Summary:  There are a lot of options in the supplements aisle, because there’s a lot of money in it.  Supplements might contain vitamins, minerals, herbs, botanicals, amino acids (part of protein), enzymes and probiotics, as well as binding agents, preservatives, flavoring agents etc.  The label claims for ingredients are required by the FDA to be “truthful and not misleading.”  If a supplement label “supports” or “promotes” proper nerve function, or cellular energy, or metabolism, the claim is so nebulous or general that it might be impossible to prove that it was untruthful or misleading.  What to do? We try to figure that out in this episode.  Topics: ·       Supplements and $$$ 01:30 ·       FDA Approved Indication – Not 02:00 ·       Disclaimer 05:00 ·       80,000 Supplements 08:30 ·       Claims:  Health; Structure-Function; Nutrient 09:30 ·       Beware – Research – Communicate w/ Healthcare Team –  Monitor          & Follow-up  12:00       *    FDA – Reports Problems/Benefits       *    Independent Labs = USP, Consumer Labs 22:00       *    Utilize and work with Healthcare Team. 23:00       Questions and comments to  [email protected]

Send us Fan Mail Summary:  The off-label use of naltrexone for chronic pain and inflammatory conditions is built upon observing patients being weaned from high dose naltrexone for alcohol abuse disorder, as well as its experimental use in boosting the immune system of HIV patients in the 1980s.  Though the long-term use of LDN for chronic pain and the other inflammatory conditions has not been established, this unique mechanism of action may, in the future, provide another proven option for those in need.   Or will it?  We are in the process of discovery. Topics: ·       Low Dose Naltrexone Potential Uses 02:00 ·       Opioid Antagonists Naloxone and Naltrexone ·       Receptor Interactions: Affinity/Intrinsic Activity/Dissociation. 04:15 ·       Naloxone & Naltrexone Chemistry ·       Antabuse 08:20 ·       Fooling the Body – Negative Feeback Loop 11:30 ·       Microglial Cells Inhibition & Anti-inflammatory actions 12:50 ·       Applied Science of Medicine 14:00 ·       LDL Risks ·       Quality of Life and Risk-Benefit 17:45 Questions and comments to  [email protected]

Send us Fan Mail Summary:  Rooting for your favorite team may very well influence your opinion of the referees in the game.  Leave bias there.  In healthcare, double-blind placebo-controlled trials and the metanalysis of studies are attempts to remove bias, so that objective reasoning can rule the day.  JFK Jr. exhibited significant bias about vaccines prior to his confirmation as Secretary of Health and Human Services, and it has been evinced in his decision to stop the funding for mRNA vaccines.   Blatant lies and unchecked bias threaten not only our healthcare options, but the very world in which they operate.   Topics: ·      Bias 01:00 ·      Double Blind Placebo Controlled Studies 01:30 ·      RFK Jr 02:20 ·      Science is a Process 04:30 ·      mRNA 05:30 ·      Mutations 06:20 ·      Bacteria Too 07:45 ·      More Bias 10:00 ·      You Are The Experiment 12:00 ·      mRNA Risk Benefit 14:15 Questions and comments to  [email protected]

Send us Fan Mail Summary:  Slinging ugly, triggering words – like “psycho-emotional problems” - is an effort to awaken stigmas in the public against a person.  Reject it.  Mental Health, like our physical health, is an ever-changing dynamic.  Though we expect mental and emotional health and stability in our leaders, the assessment of that issue should be objective and based on the best medical practice, and not on some sloppy reference intended to fan the flames of hate. Topics: ·       Psycho-Emotional Problems 01:00 ·       Unconrtrolled Fits 03:30 ·       Heavy Tranquilizers 04:30 ·       Stigma of Mental Health Challenges 05:00 ·       Public & Self Stigmas 07:00 ·       Intermittent Explosive Disorder (“Fits of Anger & Aggression”???) 09:30 ·       DSM-5 ·       Gelastic Seizures (“Fits of Cheerfulness”???) 10:40 Questions and comments to  [email protected]