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The CEO of the AARP is on a mission to have all of us recognize that people over 50 are an economic force. Their households account for 56 cents of every dollar spent in this country. Workers over 50 make up more than 40% of the workforce. Dr. Myechia Minter-Jordan joins Claudia to talk about what America would look like if our culture, workplaces, products, infrastructure and policies actually reflected this reality. Claudia and Myechia cover: Why caregiving has to move from a private family burden to a public policy priorityWhat innovators get wrong about older adultsHow closing the 12.5-year gap between lifespan and healthspan could reshape what we build, fund and prioritize Dr. Minter-Jordan says there is an economic and business rationale for moving to a longevity economy: “Our demographics are changing, people are living longer, they're staying in the workplace longer, there are now five generations in the workplace. So all of these pieces together have created the urgency for us to think differently about aging.“ Relevant Links Get more information about joining AARP Find more details on the AARP Community Challenge Grant Program Read the Credit for Caring Act Dr. Minter-Jordan mentioned About Our Guest As CEO of AARP, Dr. Myechia Minter-Jordan leads the world’s largest nonprofit, nonpartisan membership organization, harnessing the power and passion of almost 2,300 staff members, 60,000 volunteers, and numerous strategic partners. Dr. Minter-Jordan, who was named CEO in November 2024, is an accomplished physician, passionate advocate, and innovative leader who deftly merges a passion for social impact with the business acumen to make strategic decisions, foster meaningful collaboration across engaged teams, and successfully lead organizations through periods of rapid change and growth. Throughout her career, she has fought to shine a national spotlight on the importance of social equity and the far-reaching impact of philanthropy and giving back. After a successful early career in academic medicine at Johns Hopkins, where she was an attending physician and instructor, she was inspired to serve as Chief Medical Officer and ultimately President and CEO of the Dimock Center, one of the largest community health centers in Massachusetts. Dr. Minter-Jordan’s journey to transform the health care industry continued at the CareQuest Institute for Oral Health in Charlestown, Massachusetts, where she served as President and CEO from 2020 until 2024. Dr. Minter-Jordan has consistently prioritized giving back through her service on a wide range of boards and commissions, including BlueShield of California, Yawkey Foundation, Point 32 Health, and The Boston Foundation. She has received numerous awards for her contributions, including Harvard Medical School’s Reede Scholar Vision Award and the Terrance Keenan Leadership Award in Health Philanthropy from Grantmakers in Health. Dr. Minter-Jordan is a graduate of Brown University and earned her MD from the Brown University School of Medicine and her MBA from the Carey School of Business at Johns Hopkins University. She holds an Honorary Doctor of Public Service degree from Northeastern University and an Honorary Doctorate of Humane Letters from Newbury College. Source Connect With Us For more information on The Other 80 please visit our website - www.theother80.com. To connect with our team, please email [email protected] and follow us on twitter @claudiawilliams and LinkedIn Subscribe to The Other 80 on YouTube so you never miss our video extras or special video episodes!

Dr. Francis Collins served as NIH director for 12 years across three administrations (Obama, Trump, Biden), both Democrat and Republican. He brought enormous scientific vision to the role, along with a level of connection and humanity rare in any leader. A year and a half ago, he left NIH, not by his own choice. And now, he joins Claudia to ask: How do we make the case for future investments in science in a world of distrust? Dr. Collins and Claudia cover: Why he believes faith and science belong togetherWhat the Human Genome Project teaches us about taking on big scientific challengesWhat listening to people who felt harmed by the COVID response taught him about trust Dr. Collins says, for him, science and religion can walk hand-in-hand because they answer different questions: “Science is the right way to answer questions about the natural world, but it doesn't help you so much with other questions like is there a God? Why am I here? Why is there something instead of nothing? That's where faith, if you're gonna get answers at all, comes to the rescue of the silence of science. And I think it's exciting to be able to consider all those questions. And if, as it is now in my worldview, the natural world is the handiwork of a creator, then studying the natural world is also getting a glimpse of God's mind, which means science and faith are in fact connected to each other and the laboratory maybe is… And even if you want to say what you're doing in science is to uncover with awe things about creation, this feels like worship.” Relevant Links Read Vannevar Bush’s 1945 paper “Science, the Endless Frontier” See Dr. Collin’s 2003 Nature paper called “A vision for the future of genomics research” Find latest update on NIH’s All of Us Research Program Read Rebecca Skloot’s book The Immortal Life of Henrietta Lacks Explore Braver Angels, the cross-partisan, volunteer movement Dr. Collins references Listen to Carrie Newcomer’s song “If Not Now” About Our Guest Francis S. Collins, M.D., Ph.D., is the former director of the National Institutes of Health (NIH). As the longest serving director of NIH — spanning 12 years and three presidencies — he oversaw the work of the largest supporter of biomedical research in the world, from basic to clinical research. Dr. Collins is a physician-geneticist noted for his landmark discoveries of disease genes and his leadership of the international Human Genome Project, which culminated in April 2003 with the completion of a finished sequence of the human DNA instruction book. He served as director of the National Human Genome Research Institute at the NIH from 1993-2008. Dr. Collins' research laboratory has discovered a number of important genes, including those responsible for cystic fibrosis, neurofibromatosis, Huntington's disease, a familial endocrine cancer syndrome, and most recently, genes for type 2 diabetes, and the gene that causes Hutchinson-Gilford progeria syndrome, a rare condition that causes premature aging. Dr. Collins received a B.S. in chemistry from the University of Virginia, a Ph.D. in physical chemistry from Yale University, and an M.D. with honors from the University of North Carolina at Chapel Hill. Prior to coming to the NIH in 1993, he spent nine years on the faculty of the University of Michigan, where he was a Howard Hughes Medical Institute investigator. He is an elected member of the Institute of Medicine and the National Academy of Sciences. Dr. Collins was awarded the Presidential Medal of Freedom in November 2007 and the National Medal of Science in 2009. Source Connect With Us For more information on The Other 80 please visit our website - www.theother80.com. To connect with our team, please email [email protected] and follow us on twitter @claudiawilliams and LinkedIn Subscribe to The Other 80 on YouTube so you never miss our video extras or special video episodes!

Today’s guest, Dr. Meena Seshamani, ran Medicare at CMS and is now Secretary of Health in Maryland. She is leading one of the country’s most ambitious health reform efforts: evolving Maryland’s all-payer model, expanding investment in primary care, and using data infrastructure to strengthen coverage and population health—all while navigating the implementation of HR1. In this conversation, recorded at Aspen Ideas Health, Meena makes the case that policy design matters, but implementation is where its promise is realized or lost. Meena and Claudia discuss: How Maryland saved $1.6 billion for MedicareNew primary care investment strategiesHow the state is leveraging CRISP, the state’s HIE, to implement HR1 and streamline enrollment in public programs Meena shares how Maryland is strengthening food systems using rural health transformation funding: “We are also taking rural health transformation dollars and investing in cold storage, food aggregators, and distribution hubs for our local Maryland farms, so that when we are doing outreach on healthy eating and providing nutritious food to people, that's actually coming from our local Maryland farms. So it's boosting the local economy in our rural areas as well.“ Relevant Links Maryland’s Total Cost of Care Model: Evaluation of the First Four Years Article on the impact of Maryland’s model How CRISP supports Medicaid redetermination The state’s Rural Health Transformation plan About Our Guest Meena Seshamani, MD, PhD serves as the Secretary of Health for Maryland in the Moore-Miller Administration, where she stewards a $20 billion health system that encompasses public health, Medicaid, disability, behavioral health, and 11 state-run hospitals. She leads the state’s mission to improve the health and well-being of all Marylanders through a focus on accessibility, affordability, and equity. Under her leadership, Maryland has emerged as a national laboratory for healthcare innovation. Dr. Seshamani successfully negotiated a first-of-its-kind, multi-billion dollar healthcare payment model with federal partners and secured $168 million in inaugural funding to transform rural health delivery. Her tenure is also marked by a proactive approach to public health, exemplified by ensuring broad vaccine access in the state through the creation of a landmark program providing free vaccines to uninsured and underinsured residents—codifying health security as a statewide priority. Prior to her cabinet appointment, Dr. Seshamani served as Deputy Administrator and Director of the Center for Medicare at CMS. There, she executed the most significant pharmaceutical reform in decades: the Medicare Drug Price Negotiation program, achieving $6 billion in first-year savings. Her work at CMS fundamentally shifted the Medicare model to value-based care by introducing payments for community health services, caregiver training, and navigating patient care, while simultaneously tightening accountability and oversight. A board-certified head and neck surgeon and an Oxford-trained health economist, Dr. Seshamani’s perspective is grounded in how health care policy and operations impact the real lives of patients. She previously served as Vice President of Clinical Care Transformation at MedStar Health, maintaining a surgical practice while leading large-scale system changes. A widely published author in the New England Journal of Medicine and JAMA, her insights are frequently sought by The New York Times, The Wall Street Journal, and major news networks. Dr. Seshamani holds her MD from Johns Hopkins University and her PhD from the University of Oxford, where she was a Marshall Scholar. Source Connect With Us For more information on The Other 80 please visit our website - www.theother80.com. To connect with our team, please email [email protected] and follow us on twitter @claudiawilliams and LinkedIn Subscribe to The Other 80 on YouTube so you never miss our video extras or special video episodes!

Fifteen years ago Congress created the CMS Innovation Center to test new ways of delivering quality care at lower costs. Since then, the Innovation Center has tested dozens of models - some have been successes, and many have not. Director Abe Sutton joins The Other 80 for a candid conversation about the Innovation Center’s record, its next chapter, and the big bets ahead. Abe identifies three features of successful models: Mandatory participation to avoid cherry pickingDownside risk to drive provider attention and engagementMinimal gaps between first- and second-generation models to maintain momentum Abe says success should not be measured by how many models work, but by overall return on investment: “If we are taking bold bets, if we're trying to say, all right, let's back the next thing that could really transform care in a country and put the country on a more solid fiscal foundation while improving care and the affordability of care. Well, one thing that really was transformative and did that well may be worth the cost of running 20 things.” Relevant Links Read the CMS Accountable Communities Evaluation Access the GAO report evaluating the CMMI model from 2011-2024 Read the CMMI’s most recent Strategic Plan About Our Guest Abe Sutton serves as the Director of the Center for Medicare and Medicaid Innovation and Deputy Administrator for the Centers for Medicare and Medicaid Services (CMS). Before assuming this role in January of 2025, he co-founded two health service companies; Honest Health, which focuses on enabling primary care physicians, and Evergreen Nephrology, which focuses on enabling nephrologists. Sutton focused on health policy with the federal government from 2017 to 2019, serving at the National Economic Council, Domestic Policy Council and Department of Health and Human Services. In these roles, he coordinated health policy across the federal government, with a focus on the shift to paying-for-value within Medicare, increasing choice and competition in health care markets, and updating the federal government’s approach to kidney care. He holds a law degree from Harvard Law School and undergraduate degrees in political science, management, and health care management and policy from the Wharton School and the College at the University of Pennsylvania. Source Connect With Us For more information on The Other 80 please visit our website - www.theother80.com. To connect with our team, please email [email protected] and follow us on twitter @claudiawilliams and LinkedIn Subscribe to The Other 80 on YouTube so you never miss our video extras or special video episodes!

Healthcare pioneer Rushika Fernandopulle joins us to discuss his new venture Liza and why this is the perfect moment to build new primary care models from the bottom up. Rushika argues that “shareholder value” has usurped the needs of patients in US healthcare, and that fundamental rethinking, not optimizing or tweaking at the edges, is needed. Rushika shares the ‘build principles’ for Liza: Backload constraints - don’t frontload them. First show that a new approach works, then figure out the business modelTake cues from conscious capitalism: the purpose of a business is to create good in the world, not to optimize shareholder value Figure out the right thing to do, not a business that fits how healthcare is broken Rushika argues that AI invites us to rethink healthcare based on abundance, not scarcity: “We've built our whole economy, all our processes with this assumption of scarcity, that there were a scarce number of human brains who could do things, right? Doctors, teachers, et cetera. And now all of a sudden that assumption has gone away. So we need to rethink from scratch how we build these systems. So that's what we're trying to do at Liza. Like, what if we started from scratch?” Relevant Links More information on LIZA Health The book Conscious Capitalism by John Mackey et al Podcast episode where Tim Ferris and Jerry Colonna talk about sabbaticals Article by Sara Riggare about living with Parkinson's and her image of blue and red dots About Our Guest Rushika Fernandopulle is a practicing physician who is the CEO of Liza Health, a startup building a new AI-enabled platform for Primary Care. He was the co-founder and CEO of Iora Health, an early innovator in Primary Care redesign which was acquired by Amazon in 2023. Prior to this, Rushika was the first Executive Director of the Harvard Interfaculty Program for Health Systems Improvement and Managing Director of the Clinical Initiatives Center at the Advisory Board Company. He is a member of the Schweitzer, Ashoka, Aspen, and Salzburg Global Fellowships, on faculty at Harvard Medical School. He serves on the boards of the Asian American Foundation, Families USA, and Premera Blue Cross, and is a member of the Lancet Commission for Person Centered Care. He earned his A.B., M.D., and M.P.P. from Harvard University, and completed his clinical training at the University of Pennsylvania and the Massachusetts General Hospital. Source Connect With Us For more information on The Other 80 please visit our website - www.theother80.com. To connect with our team, please email [email protected] and follow us on twitter @claudiawilliams and LinkedIn Subscribe to The Other 80 on YouTube so you never miss our video extras or special video episodes!

Does the history of drugs tell us something bigger about the world? That’s what former Wired executive editor and UC Berkeley Senior Impact Fellow Thomas Goetz is betting on with his new podcast Drug Story. He joins Claudia to talk about how big drug breakthroughs have shaped how we live and what it will really take to build health in our society. Thomas and Claudia dive into: Fluoride: The paradox of public health success becoming invisibleWhy modern culture medicalizes ordinary human experiences like sleep, aging & energyHow public health needs to communicate differently, think bigger, and position itself as essential infrastructure for everyday health Thomas says the illusion of free will makes consumers feel like unhealthy choices are their choice alone: “There is some agency, like somebody decides to take a cigarette out of the pack. People decide whether to have a Coke instead of a glass of water or what have you. But there's also this vast machine, an invisible universe that is so powerful in compelling us from the commercials that are on our TV shows to the infrastructure of fast food in our neighborhoods. And it just is this easy inertia where oftentimes we don't actually have free will… We have much less free will than we think we do when it comes to things like what we eat, how we get our entertainment, where we live. There's a lot that is not really up to us and our choices.” Relevant Links Listen to Thomas Goetz’s podcast Drug Story About Our Guests Thomas Goetz is an award-winning science journalist and author. He has won National Magazine Awards (print and digital), Webby Awards, and FDA contracts. He created Drug Story as an Impact Fellow at the University of California Berkeley School of Public Health. The former Executive Editor at WIRED, he has worked at The Wall Street Journal, Inc., and the Robert Wood Johnson Foundation, and has written two award-winning books about technology and medicine. His writing has been selected for the Best American Science Writing and the Best American Technology Writing anthologies. He spent much of the past decade developing digital tools to help people make sense of prescription medications, including leading the development of openFDA for the Food and Drug Administration, and building an economic research team and editorial operations at GoodRx. You can reach him at [email protected] Source Connect With Us For more information on The Other 80 please visit our website - www.theother80.com. To connect with our team, please email [email protected] and follow us on twitter @claudiawilliams and LinkedIn Subscribe to The Other 80 on YouTube so you never miss our video extras or special video episodes!

After spending time in the Obama White House, Kumar Garg came away with a toolset of skills to help drive change, spotlight good ideas and scale them. Now he’s applying those ideas to philanthropy. As the co-founders of Renaissance Philanthropy, Kumar and Tom Kalil have built an organization around a deceptively simple idea: What if philanthropy could help scientists, technologists, and innovators think bigger — and then actually fund the work at the scale required? Kumar and Claudia dive into: Renaissance Philanthropy’s approach: time bound and thesis driven fundingHow Kumar would spend $500 million on health right nowHow public health and academics could think bigger Kumar’s intriguing ‘open notebook’ idea: “It's very valuable to me if a researcher has the equivalent of an open notebook. These are all the ideas… Here's my active research projects. Here's all the interesting sort of experiments I've done… you can imagine then sending an agent out and read[ing] people's open notebook.. it would be a way to discover people's work.” Relevant Links Learn more about Renaissance Philanthropy Get info on the Big If True Science Accelerator (BITS) See a photo of Kumar’s White House white board on Twitter About Our Guests Kumar Garg is the President at Renaissance Philanthropy. Kumar has helped to shape the science and tech landscape for almost two decades. Working with Eric Schmidt, he helped design and launch moonshot initiatives in education, provided early support to game-changing ideas and pioneers, and built ongoing multi-donor and multi-sector collaboratives. Prior to that, he helped set budget and policy priorities for the Obama Administration as part of the White House Office of Science and Technology Policy, and drove progress on topics ranging from education and workforce issues, biotechnology, entrepreneurship, space, advanced manufacturing, broadband, nanotechnology, behavioral sciences, digital media, incentive prizes, and broader innovation policy. In particular, he led the Obama Administration’s efforts to bolster science, technology, engineering and math (STEM) education, including development of major budget and policy initiatives in the State of the Union to train 100,000 excellent STEM teachers and bring computer science to all K-12 students, development of the Educate to Innovate campaign with over $1 billion in in-kind and philanthropic investment, and creation of iconic events such as the White House Science Fair. Prior to his time in government, Kumar worked on behalf of parents and children seeking educational reform as an education lawyer and advocate. Kumar received a B.A. from Dartmouth College and a law degree from Yale Law School. Source Connect With Us For more information on The Other 80 please visit our website - www.theother80.com. To connect with our team, please email [email protected] and follow us on twitter @claudiawilliams and LinkedIn Subscribe to The Other 80 on YouTube so you never miss our video extras or special video episodes!

Halle Tecco is an investor, entrepreneur, and author of the new book Massively Better Healthcare. In this live conversation, she offers advice for aspiring health tech founders, reflects on why “hustle culture” needs to be kept in check, and makes the case that founders should become anthropologists of the problems they want to solve. Most importantly, she argues that today’s founders need to be “bilingual” — fluent in both healthcare and technology. Halle and Claudia cover: The early days of Rock Health in a walkup office in SF’s ChinatownHow she learned to be a founder without the grindWhy AI is growing faster in healthcare than in any other industry Halle says there is lots of opportunity to build businesses in the healthcare industry, but you need to pick something you are passionate about: “It is extremely hard to be a founder. It is 10 times harder to be a founder in healthcare… you're working on what I think are the most important problems that we will be able to solve, but it's also really challenging. [Make] sure you're picking a problem that you're genuinely very passionate about solving. That will help drive you and be your North Star when things get inevitably very, very hard. “ Relevant Links Buy Halle’s book Massively Better Healthcare Listen to Halle Tecco’s Podcast “The Heart of Healthcare” Learn more about Rock Health Menlo Ventures report on the state of AI in healthcare About Our Guest Halle Tecco is an entrepreneur, angel investor, and podcast host passionate about fixing our healthcare system. She is the founder of Natalist, which was acquired by Everly Health in October 2021. Previously, Halle founded and ran Rock Health, and was also an Adjunct Professor at Columbia Business School, teaching the first MBA-level course on digital health investing. A proud first-generation college graduate, Halle earned an M.P.H. from Johns Hopkins University, an M.B.A. from Harvard Business School, and a B.S. from Case Western Reserve University. She has served as a Board Member to the International African American Museum since 2018, and as an Advisor to the Harvard Medical School Department of Biomedical Informatics since 2014. Halle has appeared in The New York Times, The Wall Street Journal, and CNBC. She was named as one of Goldman Sach’s Most Intriguing Entrepreneurs and listed on the Forbes 30 under 30. She has spoken at the Aspen Ideas Festival, CES, TechCrunch Disrupt, and was a SXSW Keynote speaker. Source Connect With Us For more information on The Other 80 please visit our website - www.theother80.com. To connect with our team, please email [email protected] and follow us on twitter @claudiawilliams and LinkedIn Subscribe to The Other 80 on YouTube so you never miss our video extras or special video episodes!

After moving to the US from Iran at age 17, entrepreneur and inventor Fred Khosravi went on to launch more than 20 companies and earn hundreds of patents. In this conversation, Fred reflects on the power of immigration, freedom, education and what it means to build a life in a new country. He shares how leaving Iran after the revolution shaped his willingness to take risks, his sense of purpose, and his entrepreneurial drive. Claudia and Fred also get into some of the biggest opportunities he sees ahead, from women’s health to the long-overdue shift from a healthcare system organized around visits to one centered on outcomes and connected care. This interview was recorded in person at the JP Morgan - Berkeley healthcare conference in Taipei. Fred and Claudia dive into: How in the age of AI our greatest asset is our humanityWhy institutions like the FDA are essential foundations for innovationHow specialty-driven medicine makes it hard to deliver whole person care Fred says strong regulation is the foundation, not a barrier, to America’s global leadership in biotech: “I happen to believe that the reason American medical technology and American pharmaceuticals are the most sought after in the world, if you can afford it, is because of the FDA. I like to say it's because of entrepreneurs like me, and it's because of everybody who's actually working so hard on it… We could not achieve the results that we're achieving around the world… If it weren't for the systems of standards and highest quality level thinking… that the FDA is bringing to the table.” Relevant Links Learn more about Imperative Care’s vision for treating stroke and other thromboembolic diseases About Our Guest Fred (Farhad) Khosravi is a Silicon Valley medical device entrepreneur who has held management and executive positions in both large and small medical technology enterprises over the last 30+ years. Throughout his career, he has been either the inventor or co-inventor for over 200 U.S. and worldwide granted and patent applications, making him one of the most prolific minds and leaders in the industry. However, Fred’s passion for improving people’s lives goes beyond the medtech field. He currently serves on the Board of Trustees at the Center for Strategic and International Studies, a bipartisan think tank dedicated to providing strategic national security insights to help decision makers chart a course toward a better world; is a member of the Board of Directors at Spirit of America, a nonprofit that promotes private-sector support for the safety and success of our troops and the local people they want to help; and is a convening board member for Technology for America, a nonprofit for promotion of innovation as a way to engage public-private dialogue that benefit all Americans. Fred holds a B.S. degree in mechanical engineering and graduated cum laude with an M.S. degree in mechanical engineering from Tennessee Tech University. Source Connect With Us For more information on The Other 80 please visit our website - www.theother80.com. To connect with our team, please email [email protected] and follow us on twitter @claudiawilliams and LinkedIn Subscribe to The Other 80 on YouTube so you never miss our video extras or special video episodes!

Patient innovators Liz Salmi and Hugo Campos join The Other 80 to discuss the evolving role of patients in healthcare, using the recent release of ChatGPT Health as a central lens. They delve into how AI is shifting the power dynamic by enabling greater patient agency and creating new expectations for health systems. Drawing on their personal experiences, including Liz's work with OpenNotes and Hugo's long struggle for access to his cardiac device data, they explore how technology can serve as a bridge for collaboration, rather than a source of conflict, between patients and clinicians. Claudia, Liz and Hugo talk about: How patients who are sick and scared often choose sharing over privacyWhy Hugo still can’t access his implanted device dataThe need for a new doctor-patient relationship grounded in collaboration, not control Liz says AI is surfacing the same reactions she saw around patients googling health information: “It makes me think of the Dr. Google era of when clinicians were like, ‘patients shouldn't go online and look for information about their own health because they don't know how to search accurately for their own health information’. And I think we're at this early stage of the tension between health systems wanting to still control how patients find their own health information, versus our own curiosity and exploration of digging into our own health information and… asking the questions that are important to us and then discovering the answers ourselves in our own journey.” Relevant Links Read Liz and Hugo’s paper on Critical AI Health Literacy Watch Hugo’s TEDx Talk on Fighting for the Right to Open His Heart Data Learn more about the patient data transparency movement at OpenNotes Read the full text of the 21st Century Cures Act About Our Guests Hugo Campos is an internationally recognized patient advocate, combining creative and technical expertise to promote participatory medicine and patient-centered, AI-enabled healthcare. Named a White House Champion of Change for Precision Medicine by President Obama in 2015, he advocates for patient rights and health data access while managing his own cardiac condition. Hugo serves on the NIH’s All of Us Research Program Steering Committee, co-leads patient engagement for PCORI’s THRIVE trial, and advises UCSF/UC Berkeley’s Computational Precision Health program. A TEDx Cambridge speaker, his advocacy has been featured in national media and scientific publications. Hugo lives in Oakland, California, with his husband, elderly father, and Memphis the cat. Source Liz Salmi is the Communications & Patient Initiatives Director for OpenNotes. In this role, Liz helps clinicians, hospitals and health systems understand through “the patient’s eyes” the changing nature of patient-clinician communication in an age of growing transparency. Her research areas of interest include: the effects of transparency on patient-clinician communication, stakeholder engagement, research dissemination, and the role of social media in patient-clinician-researcher collaborations. As a person living with a low grade malignant brain tumor, Liz is passionate about helping all people engage in their own health care by improving their experience as patients. Over the last 17 years she has been: a research subject; an advisor in patient stakeholder groups; a leader in “patient engagement” research initiatives; and an innovator, educator and investigator in national educational and research projects. In addition to her work with OpenNotes, Liz led the Brain Cancer Quality of Life Collaborative, a multi-stakeholder group dedicated to advancing science and improving the quality of life for people with malignant brain tumors. In fall 2021, members of the BCQoLC team (along with established investigators), were awarded a $12.8 million Center Grant from the National Cancer Institute to determine optimal methods for patient enrollment in a brain tumor registry. Source Connect With Us For more information on The Other 80 please visit our website - www.theother80.com. To connect with our team, please email [email protected] and follow us on twitter @claudiawilliams and LinkedIn Subscribe to The Other 80 on YouTube so you never miss our video extras or special video episodes!

Newly-minted Nobel laureate Fred Ramsdell joins Claudia to discuss his groundbreaking work on regulatory T cells, which act as the immune system's natural "brakes." His research aims to "reset" the immune system to cure autoimmune diseases (like rheumatoid arthritis and MS) moving beyond mere symptom management. Fred reflects on his new role as a science advocate, addressing the crisis of public trust in science and the need for greater diversity in biomedical research. During this conversation, recorded at the UC Berkeley/JP Morgan Healthcare Conference in Taipei, Claudia and Fred discuss: How Fred missed the Nobel Prize call while off-grid campingHis shifting goals in retirement post Nobel winWhy he chose biotech: collaboration, speed, and being "wrong fast"The deeper threat to science: funding vs. trust, and his surprise in Sweden Fred says he’s excited to see what other advances are possible in what he calls “the early innings” of scientific discovery: “As humans, we're really good at solving technological problems. If we know what the problem is, historically, we're pretty good at figuring out an answer. [We’re] pretty confident now that we know the problem in peripheral tolerance, that is the breakdown of our immune system recognizing our own tissues. Now we know what at least part of that problem is, we'll be able to engineer our way into a solution.” Relevant Links See more about Fred’s Nobel win and read the UCLA press release Fred’s Nobel prize lecture See Fred and his co-laureates accept their prize Read more about Fred’s 2025 co-laureates Mary E. Brunkow and Shimon Sakaguchi About Our Guest Fred Ramsdell, PhD, is a veteran biotechnology leader in immunology with nearly three decades of experience and was named a winner of the 2025 Nobel Prize in Physiology or Medicine. A co-founder of Sonoma Biotherapeutics, Dr. Ramsdell was the former Chief Scientific Officer (CSO) and current Scientific Advisory Board Chair of the Company. Dr. Ramsdell earned his doctoral degree in microbiology and immunology from the University of California, Los Angeles and holds a bachelor’s degree in biochemistry and cell biology from the University of California, San Diego. Following a fellowship at the NIH, Dr. Ramsdell joined Immunex studying T cell activation and tolerance, with a focus on gene discovery and functional characterization. He later joined Darwin Molecular (which was later acquired by Celltech R&D) to establish the immunology program. Amongst other programs, he led the team that discovered and characterized FoxP3, a gene critical to the function of regulatory T cells. Dr. Ramsdell joined ZymoGenetics in 2004, where he led teams studying novel proteins with potential regulatory activity in lymphoid cells. In 2008, Novo Nordisk brought on Dr. Ramsdell to help establish the company’s new Inflammation Research Center in Seattle and lead the Immunobiology group. Prior to SonomaBio, Dr. Ramsdell was the CSO at the Parker Institute for Cancer Immunotherapy (PICI) where he helped to build and advance multiple research programs from the inception of the Institute. Source Connect With Us For more information on The Other 80 please visit our website - www.theother80.com. To connect with our team, please email [email protected] and follow us on twitter @claudiawilliams and LinkedIn Subscribe to The Other 80 on YouTube so you never miss our video extras or special video episodes!

When Mayor Lurie took office, San Francisco was spending nearly $1 Billion a year responding to homelessness, yet the number of people living unsheltered had not budged in years. In this episode, Kunal Modi, the city’s Chief of Health and Human Services, shares how the Lurie administration is tackling the intersecting homelessness, mental health and addiction crises. Rather than layering on new programs, the city is attempting something harder: redesigning how fragmented systems work together. Kunal and Claudia discuss: The city’s move to unify fragmented and siloed outreach teamsThe importance of shifting accountability and decision-making to the front linesHow San Francisco’s strategy is leveraging the community supports in CalAIMWhy solutions need to reflect the intersecting nature of the homeless problem Kunal reminds us that ending the cycle of homelessness is far more complicated than just finding housing: “This is more than a homelessness crisis, it's an intersecting homelessness, behavioral health, and drug addiction crisis that we need to bring our healthcare system and our social service system in closer alignment… We need to reorient our Public Health strategies to not only support those in crisis, but to think about the broader communities and neighborhoods.” Relevant Links See Mayor Lurie’s thoughts on the “Breaking the Cycle” initiativeGet more information on the City’s new RV parking restrictionsRead the Crankstart report on tackling homelessness in San Francisco About Our Guest Kunal Modi is the policy chief of health, homelessness, and family services in San Francisco Mayor Daniel Lurie’s administration. In this role, he coordinates eight agencies, including the Department of Homelessness and Supportive Housing, the Department of Children, Youth and Families and the Department of Early Childhood, while also serving as liaison to San Francisco Unified School District and City College. He brings extensive experience in cross-agency collaboration and reform, aiming to deliver compassionate, effective solutions for the city’s most pressing health, housing, and family needs. Before joining City Hall, he spent over 11 years as a partner at McKinsey & Company’s Bay Area office and previously served on the boards of Larkin Street Youth Services and St. Anthony’s Foundation. His educational background includes an M.B.A. from Harvard Business School, an M.P.P. from Harvard Kennedy School, and a B.A. from Northwestern University. Connect With Us For more information on The Other 80 please visit our website - www.theother80.com. To connect with our team, please email [email protected] and follow us on twitter @claudiawilliams and LinkedIn Subscribe to The Other 80 on YouTube so you never miss our video extras or special video episodes!

Not many digital health companies go public. And even fewer do so with a model designed to fix what’s truly broken in U.S. healthcare: episodic, fragmented care that fails to support the behavior change required to manage chronic disease. Omada Health CEO Sean Duffy joins Claudia to discuss the company’s journey from scrappy startup to public company—and his biggest ambition for the future: bending the nation’s chronic disease curve, both in cost and in human suffering. Claudia and Sean talk about: Omada’s “full stack” approach to chronic careWhat Omada’s IPO signals for digital health’s futureWhy GLP1s are a catalyst for behavior changeHow employers have quietly driven healthcare innovation Sean says for Omada to actually shift what consumers pay out of pocket every month for their premiums we need to make big changes: “Affordability is the thing… That's the burden we're bearing as a country… And so, the only way to bring down healthcare costs are completely transformed care models. That's the only way… Thank goodness we're at a moment where those models are being supported and being scaled nationally. Thank goodness we're at a moment where technologies like AI can help add even more efficiency and help scale… Our only way out are different care models [that] leverage new technologies.” Relevant Links Access more info in Omada’s research library Get details on Omada Health’s S1 IPO Filing See the GLP-1 research Sean mentions: Omada members maintain weight loss after discontinuing GLPs Get more info on the CMS ACCESS model About Our Guest Sean Duffy co-founded Omada in 2011 with the aim of merging medical trends and cutting edge technology to revolutionize health care of chronic disease as we know it. Today, he proudly serves as CEO and has been instrumental in steering Omada toward global recognition, such as being hailed a potential “medical triumph” by The New York Times, and one of Fast Company’s 50 most innovative companies in the world. A longtime devotee of healthcare and technology, Sean also founded a largely automated lifestyle business around Excel Everest, the interactive Microsoft Excel training tool he created. He formerly covered healthcare innovation as writer and editor for Medgadget, a popular medical technology blog. As CEO of Omada, Sean cares deeply about honing the organization’s exceptional products, values-driven approach to healthcare, and the innovative ways in which primary care can continue to better humanity. More recently, Sean has been spending more and more of his free time learning how to build and fly first-person view drones. Source Connect With Us For more information on The Other 80 please visit our website - www.theother80.com. To connect with our team, please email [email protected] and follow us on twitter @claudiawilliams and LinkedIn Subscribe to The Other 80 on YouTube so you never miss our video extras or special video episodes!

In 2025, New Mexico made history as the first state in the nation to commit to free childcare for all families. Elizabeth Groginsky, who leads this effort, joins Claudia to discuss what Governor Michelle Lujan Grisham has described as a “cradle-to-career education system”—and why investing early pays dividends from school readiness to family economic stability. Claudia and Elizabeth dive into: The critical link between fair worker wages and childcare capacityHow New Mexico’s early childhood trust fund is helping the state stay the courseWhy NYC and other cities and states want to replicate New Mexico’s moveUnexpected allies in the state’s quest to provide free childcare Elizabeth underscores this is not only good social policy but also a smart financial investment: “If we believe the Heckman equation, if we believe the economists coming out of the Federal Reserve, this is your best investment. If it's a 7 % return, that's better than anyone's getting on any portfolio. It could be as high as a 13 % return… And so it's not going to be a question of ”How can we afford it?”, but “How can we not afford to invest in universal child care?”” Relevant Links Find out more about New Mexico’s Childhood Education and Care DepartmentRead more about Universal Childcare in New MexicoWhat is the Heckman Equation?See information on the “Developing Futures” Campaign About Our Guest Elizabeth Groginsky has more than two decades of executive leadership experience administering public and private human service organizations at the national, state and local levels. She previously served as the assistant superintendent of early learning for the District of Columbia, a role she held for nearly five years where she administered a $160 million annual budget that funded programs to ensure equal access to quality services for the District’s most vulnerable children and their families. The District of Columbia was first in the nation in 2009 to pursue universal pre-K and today has the highest U.S. participation rate, with 85 percent of all 4-year-olds and 75 percent of 3-year-olds. She previously directed early childhood education for United Way Worldwide, where she helped expand the number of communities collecting and using population-based early childhood data; and she was the first executive director of the Early Childhood Data Collaborative, a national coalition to improve state policies and practices in the development and use of early childhood data system. Her experience with Head Start programs is extensive: She began as a family services coordinator, later administered a county program and then directed the Head Start Collaboration Office for Colorado. In Washington, D.C., she oversaw one of only eight state Early Head Start Child Care Partnership grants. Groginsky earned a master’s degree in social sciences from the University of Colorado at Denver and a bachelor’s degree from the University of Maryland. Source Connect With Us For more information on The Other 80 please visit our website - www.theother80.com. To connect with our team, please email [email protected] and follow us on twitter @claudiawilliams and LinkedIn Subscribe to The Other 80 on YouTube so you never miss our video extras or special video episodes!

This week, we close out our three-part series on rethinking drug access and costs with a must-listen encore episode. After detailing the scope of the drug price crisis with Mark Cuban and how we can re-purpose drugs to treat rare illnesses with David Fajgenbaum, we turn to a leader who is actively changing the dynamic: Paul Markovich. Now the CEO of Ascendiun (the parent company of Blue Shield of California), Paul argues that healthcare affordability isn't just a patient pocketbook issue - it’s a massive economic crisis for the nation. In this episode, Paul and Claudia discuss: His conviction that reducing healthcare costs is essential to averting a national fiscal crisisThe upside-down economics that make PBMs reject cheaper drug pricesPaul’s candid advice on what it takes to be a courageous leader in a dysfunctional system Paul Markovich challenges healthcare leaders to shift from explaining high costs to being accountable for lowering them: “Almost everybody in the entire value chain, whether it's health plans or hospitals or all the way through, they want to explain why healthcare is so expensive and why there's this inflation rate as if that absolves them of any responsibility to make it different. And so, what I really want is accountability, and a level of accountability that doesn't exist yet in our industry, to say, 'Hey, we own this' ".  Relevant Links Part 1: Listen to our episode “New Life for Old Drug with David Fajgenbaum” Part 2: Listen to our episode “Lessons in Disruption with Mark Cuban” Rethinking how Americans get affordable medications California’s new PBM reform law About Our Guest Paul Markovich is president and chief executive office of Ascendiun, a nonprofit corporate entity as part of the new parent to the family of organizations that includes Blue Shield of California. Paul Markovich was president and chief executive officer at Blue Shield of California, a nonprofit health plan with $25 billion in annual revenue, serving 6 million members in the state's commercial, individual, and government markets. Paul launched and led numerous initiatives to drive innovation and help reimagine health care, including funding support for a statewide provider directory to make it easier for Californians to find physicians and facilities in their plan; supporting the development of a statewide health information network for patients’ records, enabling more seamless and holistic care; and investing in a partnership with the California Medical Association to help physicians pilot new care delivery models and leverage technology. At Blue Shield, Paul previously served as chief operating officer (responsible for healthcare services, network management, e-business, marketing, product development, and customer operations). He was senior vice president of the large group and CalPERS business units. He led the company’s product development unit, introducing numerous products and services such as the first California Health Maintenance Organization to allow self-referrals to specialists and initiating online access to member benefits. He currently serves on the board of the Chicago-based Blue Cross Blue Shield Association, the national umbrella organization across the country. Together, these plans provide health coverage for more than 100 million Americans. Paul also serves on the board of America’s Health Insurance Plans. Paul is a North Dakota native and Rhodes Scholar with a master’s degree in philosophy, politics, and economics from Oxford University. He is a graduate of Colorado College, where he earned a Bachelor of Arts degree in International Political Economy and played Division I hockey. Source: https://www.linkedin.com/in/paul-markovich/ Stay Informed Sign up for The Other 80 Newsletter to receive a monthly update with reflections, news, events, jobs and funding curated for you by Claudia. Click here to sign up. Connect With Us For more information on The Other 80 please visit our website - www.theother80.com. To connect with our team, please email [email protected] and follow us on twitter @claudiawilliams and LinkedIn.