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For nearly a century, reports of a mysterious psychoactive bolete have puzzled ethnomycologists and anthropologists alike. From the 1930s reports of "mushroom madness" in the highlands of Papua New Guinea, which drew the curiosity of R. Gordon Wasson, Roger Heim, and Albert Hofmann, to modern Yunnan, China, where accidental poisonings from undercooked culinary mushrooms cause people to reliably see visions of tiny, colorfully dressed "little people." In this episode of The Brainforest Café, Dennis McKenna sits down with mycologist and PhD candidate Colin Domnauer (University of Utah) to discuss how modern genomics, natural product chemistry, and fieldwork cracked this long-standing mystery. Colin shares his journey traveling to the markets and forests of Southwest China and the Philippines, using DNA sequencing to identify the primary species responsible (Lanmaoa asiatica), conducting groundbreaking rodent bioassays, and exploring what these non-psilocybin compounds could reveal about the neurobiology of perception and the cross-cultural phenomenon of Lilliputian hallucinations. - - - Colin is a Bay Area California native whose research focuses on unravelling the ethnomycological mystery of psychoactive bolete mushrooms. With a lifelong interest and undergraduate degree in astronomy before changing his studies to the ethnobiology of psychoactive substances, Colin has always felt attracted to explore the mind-bending wonders of nature. In his free time, he enjoys engaging in just about any outdoor activity with friends, most of all foraging for mushrooms. Learn more about your ad choices. Visit megaphone.fm/adchoices

Dennis McKenna sits down with scholar, lawyer, and philosopher Tam Hunt (UC Santa Barbara’s META Lab) to dive deep into the mysteries of consciousness, psychedelics, and the existential crossroads of artificial intelligence. Tam shares his unconventional journey, from growing up in a 1970s counterculture commune to transformative, high-dose LSD journeys in Waimea Canyon, and how these experiences led him to co-develop the General Resonance Theory (GRT) with Jonathan Schooler. Together, Dennis and Tam explore panpsychism, Whiteheadian process philosophy, the limits of reductionist neuroscience, plant intelligence, and whether future AI built on electromagnetic "field computing" could become conscious. They conclude with a candid discussion on AI safety, existential risk, the approaching 2030 Singularity, and why the principle of stewardship as love is essential for humanity's survival. Learn more about your ad choices. Visit megaphone.fm/adchoices

Jonathan Dickinson, CEO and co-founder of Ambio Life Sciences and author of Ibogaine and the Bicameral Mind, returns to the Brainforest Café for part two of his conversation with Dr. Dennis McKenna. Where part one followed the personal journey, this one goes into the machinery: what ibogaine is actually doing to the mind and to the cell. - - - Jonathan Dickinson, co-founder and CEO of Ambio Life Sciences and founder of Terragnosis, joins Dr. Dennis McKenna on the Brainforest Café for a conversation about ibogaine, iboga, and the Bwiti tradition of Gabon. A Mexico-licensed psychologist and former executive director of the Global Ibogaine Therapy Alliance, Jonathan helped develop the field's foundational safety guidelines and completed the first Nagoya-compliant export of Tabernanthe iboga root. In part one of a two-part conversation, he traces the path from harm reduction work in Vancouver's Downtown Eastside to initiation in Gabon, and explains why ibogaine refuses to behave like a pharmaceutical. It does not reduce symptoms. It opens a door, and the person has to walk through it. Learn more about your ad choices. Visit megaphone.fm/adchoices

Jonathan Dickinson, co-founder and CEO of Ambio Life Sciences and founder of Terragnosis, joins Dr. Dennis McKenna on the Brainforest Café for a conversation about ibogaine, iboga, and the Bwiti tradition of Gabon. - - - Jonathan Dickinson, a Mexico-licensed psychologist and former executive director of the Global Ibogaine Therapy Alliance, Jonathan helped develop the field's foundational safety guidelines and completed the first Nagoya-compliant export of Tabernanthe iboga root. In part one of a two-part conversation, he traces the path from harm reduction work in Vancouver's Downtown Eastside to initiation in Gabon, and explains why ibogaine refuses to behave like a pharmaceutical. It does not reduce symptoms. It opens a door, and the person has to walk through it. Learn more about your ad choices. Visit megaphone.fm/adchoices

What if the future of ayahuasca isn’t in the hype cycle, but in safety, tradition, and real transformation? In this conversation, Sam Believ and Dennis McKenna explore Colombia’s overlooked ayahuasca lineage, the importance of set and setting, and why plant medicine may hold a key to healing both people and culture. - - - Sam Believ is the founder of LaWayra Ayahuasca Retreat and host of the Ayahuasca Podcast. ​A former offshore engineer turned modern bridge-builder, Sam is dedicated to making traditional Amazonian medicine accessible, safe, and grounded for the modern world.  He build LaWayra - currently the biggest Ayahuasca retreat in Colombia, while raising 3 small kids all in 2 foreign languages and without any business background. At LaWayra he has guided close to 3000 people through their Ayahuasca experience.  Learn more about your ad choices. Visit megaphone.fm/adchoices

In this conversation, Patricia Eastman and Dennis McKenna explore the deeper meaning of psychedelic healing through the lens of ancestral wisdom, initiation, and nature-based practice. Patricia shares the story behind her book Seeding Consciousness and her vision for Hu Azores, a retreat center in Portugal designed as a healing space that integrates architecture, ritual, and circadian-aware design. The discussion moves beyond symptom treatment and into a bigger question: how psychedelics can support creativity, integration, and a more connected human experience. - - - Patricia Eastman, Initiated is a Bwiti Traditional Practitioner for over 11 years and founder of the nonprofit Ancestral Heart, has curated transformative retreats with plant medicines worldwide as well as facilitated the psychospiritual program with ibogaine and 5-MeO-DMT at Crossroads Treatment Center in Mexico. A renowned speaker, artist, and writer, Eastman has engaged with audiences at Stanford University, the World Economic Forum, and on Gaia TV's Psychedelica. Eastman is the author of Seeding Consciousness: Plant Medicine, Ancestral Wisdom, and Psychedelic Initiation. Learn more about your ad choices. Visit megaphone.fm/adchoices

In 2003, Carlos Tanner woke up in his car underwater, having blacked out behind the wheel and driven into a river. Deep in an opiate addiction, he went to the Amazon to save his own life. What he found there became his life's work. In this episode of the Brainforest Café, Dennis McKenna sits down with Carlos, founder of the Ayahuasca Foundation in Iquitos, Peru, for a wide-ranging conversation on healing, tradition, and what happens when a sacred medicine goes global. Carlos recounts his apprenticeship under the late curandero Don Juan Tangoa Paima, who first took him in, and how that path led him to build the Ayahuasca Foundation around one idea: to give the next person the map he never had. He and Dennis also trace a shared history back to their involvement in the documentary The Shaman and the Scientist. At the heart of the conversation is a tension they both clearly feel. Both support plant medicine, yet don’t fully agree on where it should go. Dennis, who first brought the ayahuasca vine to Hawaii in 1976, is openly conflicted about his role in spreading it globally. Carlos presses the question: you can move the plant, but can you move what makes it heal? Learn more about your ad choices. Visit megaphone.fm/adchoices

In this episode of the Brainforest Café, Dennis McKenna sits down with medicinal chemist Matt Metcalf to explore a genuinely strange frontier: testing drugs in pea seedlings and the touch-sensitive Mimosa pudica instead of in mice. Along the way they circle the question that started it all, why the opium poppy spends so much energy making opioids at all, and what those molecules might be doing inside a plant that has no nerves. - - - Matthew Metcalf is a neuroscientist with a background in the medicinal chemistry and pharmacology of opioids and cannabinoids as analgesic drugs. He is an assistant professor of Medicinal Chemistry at the Massachusetts College of Pharmacy and Health Sciences University (MCPHS) School of Pharmacy - Worcester. His current research focuses on the development of New Approach Methodologies (NAMs, sometimes called Non-Animal Models) drug tests to limit the use of animals used in drug testing. His current work focuses on the use of living plants as the biological organisms to replace animal models used as drug tests. Outside of his research he is passionate about auroras and timelapse photography. Learn more about your ad choices. Visit megaphone.fm/adchoices

Dennis McKenna sits down with his old friend Dr. Cedric Baker, an ethnopharmacologist and medical herbalist who studies the ethnobotany of food across more than thirty countries. Together they take apart one of modern medicine's most stubborn assumptions: that food and medicine are separate things. From Thai kitchens where every dish is therapeutic, to the world's longevity hotspots, to the ethics of who owns a plant, it's a conversation that will leave you looking at your own plate a little differently. - - - Cedric Barrett Baker is an ethnopharmacologist, food ethnopharmacognoist, medicinal food ethnobotanist, integrative oncology medical herbalist, pharmaconutrition research scientist, & medical botany, pharmacognosy and pharmacy historian. He is also a licensed Rph. Learn more about your ad choices. Visit megaphone.fm/adchoices

As the psychedelic renaissance surges, wild sources are collapsing under demand—peyote takes decades to grow, safrole extraction is destroying Southeast Asian forests, and Sonoran Desert toads are being overharvested. In his book Bioengineering Enlightenment, Prof. Jeffrey Gerst proposes a radical solution: engineer yeast or fast-growing plants to produce psychedelic compounds sustainably. But at what cost? Dennis McKenna warns this could strip these substances from their cultural and ecological roots, veering into biopiracy. Together, they debate biotech vs. tradition, exploring alternatives like community-led agroforestry, symbiotic rights, and the “Om Fund” to return profits to Indigenous stewards. They also revisit Terence McKenna’s “Stoned Ape” hypothesis, asking whether paleogenomics could experimentally probe the evolution of human consciousness. - - - Jeffrey Gerst, born and raised in New York, is a Professor of Biology with over three decades of academic experience. He began his career at the Mount Sinai School of Medicine and has since held a long-standing position at the Weizmann Institute of Science in Israel, where he serves as the Besen-Brender Chair of Microbiology and Parasitology. His research focuses on how proteins are correctly localized within cells, particularly through the trafficking of messenger RNA (mRNA), a process essential for normal cellular function and disease prevention. Among his key contributions, Gerst’s work has demonstrated that mammalian cells can transfer mRNA between one another, revealing a novel form of intercellular communication. His lab is now exploring this mechanism as a potential gene therapy approach to treat rare genetic disorders such as Tay-Sachs, cystic fibrosis, and Gaucher’s disease by enabling targeted RNA delivery within the body. In addition to his biomedical research, Gerst advocates for the sustainable production of psychedelic compounds using genetic engineering. He is the author of Bioengineering Enlightenment and has presented this work at major scientific conferences. Learn more about your ad choices. Visit megaphone.fm/adchoices

Dennis McKenna sits down with journalist Mattha Busby to discuss the evolving world of psychedelics, including ayahuasca, ibogaine, 5-MeO-DMT, coca policy, drug reform, and the risks and realities behind psychedelic retreats and clinics. Mattha shares stories from the front lines of psychedelic journalism and reflects on the cultural, scientific, and political forces shaping the future of consciousness research. - - - Mattha Busby is a freelance journalist who has covered drug policy, psychedelics, culture and society for VICE, WIRED, Rolling Stone, The Guardian, LA Times and Esquire. He is the author of two slim volume books, Should All Drugs Be Legalized? (Thames & Hudson, 2022) and Psychedelics: A Pocket Primer (Hoxton Mini Press, 2025). He is represented by literary agents Aevitas Creative and is currently working on his first novel. He has also given keynotes on psychedelic culture on both sides of the Atlantic. Learn more about your ad choices. Visit megaphone.fm/adchoices

In this rich and thought-provoking conversation, Dennis McKenna speaks with philosopher Mandi Astola about Terence McKenna, psychedelics, epistemology, shamanism, and the nature of knowledge. Together they explore how psychedelic experiences can produce both genuine insight and dangerous overconfidence, why intellectual humility matters, and how science and shamanic ways of knowing can complement each other. The discussion also touches on the “Stoned Ape” theory, the Timewave, the trickster archetype, and the role of psychedelics as tools for understanding reality, consciousness, and human evolution. A fascinating dialogue for anyone interested in philosophy, altered states, ethics, and the limits of what we know. - - - Mandi Astola is a philosopher specializing in epistemology, ethics and ethics of technology. She is assistant professor at Delft University of Technology's philosophy section.  In particular, Mandi's work focuses on character and what features of character make someone a good person, or a good thinker. She is also part of a project, involving multiple universities, that investigates the contribution that various disciplines in the arts can make to ethical reflection on new technologies. Learn more about your ad choices. Visit megaphone.fm/adchoices

Join Dennis McKenna and Viktor Wynd for a fascinating conversation on dark fairy tales, strange museum curiosities, Papua New Guinea, storytelling, collecting, and the hidden intelligence of nature. Viktor Wynd, writer, artist, and founder of the Museum of Curiosities, shares stories from his travels, his love of folklore, and his perspective on art, books, and the living world. For viewers interested in folklore, ethnobotany, consciousness, rare books, oddities, and the intersection of science, spirit, and wonder. - - - Viktor Wynd is a writer, artist, and the proprietor of the eponymous Museum of Curiosities, Fine Art and UnNatural History in London. He regularly leads expeditions to Papua New Guinea, the Congo and beyond, taking small groups with him via his boutique travel agency Gone with the Wynd. He is the author of Viktor Wynd's Cabinet of Wonders and The UnNatural History Museum, both published by Prestel. Learn more about your ad choices. Visit megaphone.fm/adchoices

Legal Disclaimer: The following content explores the chemistry and history of psychoactive plants for educational research. No Medical Claims: The Brainforest Café Podcast and Dennis McKenna do not make any claims regarding the health benefits or safety of the substances discussed. Any statements made by the guest regarding physical effects or health outcomes are personal anecdotes and should not be interpreted as medical advice. Safety & Legality: This conversation includes theoretical discussions on chemical synthesis. We do not encourage illegal activities or the handling of potentially toxic compounds (such as Ergot fungi). Please adhere to all local laws and regulations. - - - Chemist Matthew Stahl shares with Dennis McKenna his discovery that ancient Eleusinian kykeon likely used barley infected with a safe fungus, mixed with young barley's natural plant compounds under mild acid to transform a mild substance into a powerful, LSD-like visionary brew with no nausea. - - - Matthew Stahl learned Lab chemistry while attending Texas A&M University and Texas Lutheran University for 4 years at Texas A&M University and 2 years at Texas Lutheran University. He has worked in the Automotive production industry for 32 years, in the quality department, with chemistry, to achieve enhanced safety and better performance. Matthew Stahl has read at least 200 books on psychedelics, numerous papers, and studied psychedelics for around 24 years. Learn more about your ad choices. Visit megaphone.fm/adchoices

Join Dennis McKenna in this insightful conversation with Rebecca Lazarou as they explore the urgent need to preserve ancestral medicinal plant knowledge, the role of ethnopharmacology, and how traditional herbal wisdom can be protected for future generations. Rebecca shares the story behind her PhD research on Cypriot medicinal plants and her mission to document at-risk ethnobotanical knowledge before it disappears. They also discuss citizen science, cultural heritage, biodiversity, and the connection between science and traditional healing. - - - IMPORTANT NOTICE: Due to unforeseen circumstances the activities for Rebecca's event in London has now shifted. The date and location will be the same, and it will still be a highly educational event but it will now be a more intimate home herbalism medicine making workshop. Participants will learn all about medicinal plants, the medical system, and will be making their own teas to take home with herbs focused on mental health and stress. Rebecca will also talk about ethnobotany, have a herbal tea bar, and all proceeds still go towards supporting her research. - - - Rebecca Lazarou’s work is an ecology of different disciplines spanning across medical science, ethnopharmacology, herbalism, holistic healthcare, cannabis and psychedelics. She is also an activist, writer, speaker and herbal formulator. She is currently a PhD candidate at Kew Gardens and UCL School of Pharmacy with a focus on ethnopharmacology and herbal medicines. She was the science and managing editor for the ESPD55 volume, is currently co-editor for education charity Herbal Reality and founded Laz The Plant Scientist to bring quality, sustainably sourced herbal medicines and education to people. She is passionate about democratizing knowledge, and rekindling ethnobotany and herbalism from being marginalised disciplines to part of common knowledge again. Ultimately her aim is to help nurture our relationship with nature through natural medicines, and support our species return back to Earth centred living. She is devoted to science to demystify these topics, but equally I am committed to rekindling the magic, awe and healing we find on our precious Earth. You can read more about her work at rebeccalazarou.com Learn more about your ad choices. Visit megaphone.fm/adchoices