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MeSsy with Christina Applegate & Jamie Lynn Sigler

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Rating
★★★★★
4.9
from
3698 reviews
This podcast has
146 episodes
Language
English
Explicit
Yes
Date created
2024/03/04
Latest episode
2026/10/27
Average duration
50 min.
Release period
5 days

Description

On this podcast, Christina Applegate and Jamie Lynn Sigler get vulnerable about the curveballs that life can throw…theirs just happens to be MS. Join them each week as they self-reflect, learn, laugh, and grow through their own raw and often-times hilarious conversations with each other, friends, co-stars, and the people that keep them going through the messiness of life.

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Podcast episodes

Check latest episodes from MeSsy with Christina Applegate & Jamie Lynn Sigler podcast


We're All Just Living This MeSsy Life
2026/10/27
This week, Christina and Jamie read listener emails and discuss navigating life without a diagnosis, the challenges of parenting teenagers, learning to accept help, and the realities of getting older. Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick Audio Engineer: Josh Windisch This episode is sponsored by: Novartis in neuroscience Our ambition is to create a transformational impact for people living with severe neurological conditions and their caregivers by discovering, developing and delivering innovative medicines that change the course of disease progression. OneSkin 0 Get 15% off OneSkin with the code MESSY at https://www.oneskin.co/MESSY #oneskinpod MyAlloy - With Alloy, your best hair isn’t behind you. Visit https://MyAlloy.com and use the code MESSY to get 20 percent off your first order. Your menopause-specialized doctor will tailor your care to your needs — plus, you get zero dollar unlimited messaging with your doctor. This code is valid on products only.   Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.
Christina Is Back (Part 2) with Dr. Marwa Kaisey
2026/10/20
In part two of their conversation, Jamie and Christina are joined by Dr. Marwa Kaisey, an Associate Professor of Neurology at Cedars-Sinai in Los Angeles. Send us an email: https://www.messythepodcast.com/contact Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick Audio Engineer: Josh Windisch This episode is sponsored by: Novartis in neuroscience Our ambition is to create a transformational impact for people living with severe neurological conditions and their caregivers by discovering, developing and delivering innovative medicines that change the course of disease progression. Ridge - One thing to pack, five ways to power! Get 10% Off @Ridge with code MESSY at https://www.Ridge.com/messy NOCD - If you're struggling with OCD or unrelenting intrusive thoughts, NOCD can help. Book a free 15 minute call to get started: https://learn.nocd.com/messy     Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.
Christina Is Back (Part 1)
2026/10/20
Christina is finally back! This week, she returns to MeSsy and joins Jamie to catch up on everything that’s been going on in her life over the past six months. Send us an email: https://www.messythepodcast.com/contact Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick Audio Engineer: Josh Windisch This episode is sponsored by: Novartis in neuroscience Our ambition is to create a transformational impact for people living with severe neurological conditions and their caregivers by discovering, developing and delivering innovative medicines that change the course of disease progression. ZocDoc - Head to https://Zocdoc.com/messy to get started and check that appointment off your to-do list! Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.
Learning to Love Every Version of Yourself with Tiffani Thiessen
2026/10/13
This week, Jamie is joined by Tiffani Thiessen. They talk about growing up in the spotlight, navigating rejection, embracing aging, and learning to love every version of yourself.  Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick Audio Engineer: Josh Windisch This episode is sponsored by: Novartis in neuroscience Our ambition is to create a transformational impact for people living with severe neurological conditions and their caregivers by discovering, developing and delivering innovative medicines that change the course of disease progression. Lola - Get 40% off select Lola Blankets products at https://Lolablankets.com by using code MESSY at checkout. Experience the world’s #1 blanket with Lola Blankets. Jones Road - Use code MESS  at jonesroadbeauty.com to get a Free Gift with your first purchase! #JonesRoadBeauty #ad K18 - Shop at Sephora or get 10% off your first purchase at https://k18hair.com with code [MESSY] Blissy - Wake up with clearer skin, smoother hair, and cooler sleep. Use code MESSY for an extra 30% off at blissy.com/MESSY. Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.
What If You’re Not Stuck, You’re Just in Between? with Emmanuelle Chriqui
2026/10/06
This week, Jamie is joined by her friend, actress Emmanuelle Chriqui. They talk about grief, the friendships that carry us through hard times, getting older, learning to separate your self-worth from your career, and more.  Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick Audio Engineer: Josh Windisch This episode is sponsored by: Novartis in neuroscience Our ambition is to create a transformational impact for people living with severe neurological conditions and their caregivers by discovering, developing and delivering innovative medicines that change the course of disease progression. Honeylove - Save 20% Off Honeylove by going to https://honeylove.com/messy #honeylovepod Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.
I Don’t Have a Lot of Fight in Me Right Now
2026/09/29
This week, Jamie reads listener emails and discusses parenting with MS, learning to embrace mobility aids, and navigating unsolicited advice and comparisons.  Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick Audio Engineer: Josh Windisch This episode is sponsored by: Novartis in neuroscience Our ambition is to create a transformational impact for people living with severe neurological conditions and their caregivers by discovering, developing and delivering innovative medicines that change the course of disease progression. MudWtr - Start your new morning ritual & get up to 43% off your @MUDWTR with code MESSY at  https://mudwtr.com/MESSY! #mudwtrpod Alloy -With Alloy, your best hair isn’t behind you. Visit https://MyAlloy.com and use the code MESSY to get 20 percent off your first order. Your menopause-specialized doctor will tailor your care to your needs — plus, you get zero dollar unlimited messaging with your doctor. This code is valid on products only. Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.
How to Live With What You Can’t Control with Ana Rodriguez
2026/09/24
In the final episode of Living With It, Jamie sits down with her therapist, Ana Rodriguez, to talk about what it really means to heal when life doesn’t go according to plan. They explore grief, resilience, uncertainty, and the ways we avoid our feelings by trying to fix them or find meaning too quickly. Novartis in neuroscience o Our ambition is to create a transformational impact for people living with severe neurological conditions and their caregivers by discovering, developing and delivering innovative medicines that change the course of disease progression. Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.
The Hardest Fight Is Learning to Rest with Alberto Crane
2026/09/22
This week, Jamie sits down with jiu-jitsu champion and former UFC fighter Alberto Crane to talk about how his MS diagnosis forced him to redefine what it means to be strong. Alberto opens up about learning to slow down, embrace rest, and why sometimes being a fighter means knowing when not to push through. Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick Audio Engineer: Josh Windisch This episode is sponsored by:  Novartis in neuroscience Our ambition is to create a transformational impact for people living with severe neurological conditions and their caregivers by discovering, developing and delivering innovative medicines that change the course of disease progression. OneSkin - Get 15% off OneSkin with the code MESSYat https://www.oneskin.co/MESSY #oneskinpod Zoc Doc - Ready to be seen? Check that appointment off your to-do list with Zocdoc https://zocdoc.com/ messy #sponsored Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.
Stop Apologizing for Wanting More with Heather Dubrow
2026/09/17
This week on Living With It, Jamie sits down with Heather Dubrow for an honest conversation about embracing life’s pivots, protecting your peace, and giving yourself permission to want more.  Novartis in neuroscience o Our ambition is to create a transformational impact for people living with severe neurological conditions and their caregivers by discovering, developing and delivering innovative medicines that change the course of disease progression. Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.
There Is Beauty Within All of This Pain with Lindsey Kraft
2026/09/15
This week on MeSsy, Jamie sits down with her longtime friend, actress, writer, and musician Lindsey Kraft. They talk about growing up together, navigating rejection and self-doubt, and Lindsey’s unexpected journey from acting to writing her own one-woman musical. Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick Audio Engineer: Josh Windisch This episode is sponsored by:  Take the MeSsy Survey - Please help out the show by taking our survey at https://messythepodcast.com/survey Novartis in neuroscience Our ambition is to create a transformational impact for people living with severe neurological conditions and their caregivers by discovering, developing and delivering innovative medicines that change the course of disease progression. Lola - Get 40% off select Lola Blankets products at https://lolablankets.com by using code MESSY at checkout. Experience the world’s #1 blanket with Lola Blankets. K18 - Shop at Sephora or get 10% off your first purchase at https://k18hair.com with code MESSY. That’s code MESSY at k18hair.com   Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.
Falling Apart to Come Back Together with Ryan Weiss
2026/09/10
This week on Living With It, Jamie sits down with her friend, Ryan Weiss. They talk about letting go of control, sitting with difficult emotions, knowing when it’s time to do things differently, and learning to trust what’s on the other side when life doesn’t look the way you thought it would. Novartis in neuroscience o Our ambition is to create a transformational impact for people living with severe neurological conditions and their caregivers by discovering, developing and delivering innovative medicines that change the course of disease progression.   Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.
Thank God I’m So Neurotic with Cat Cohen
2026/09/08
This week on MeSsy, Jamie sits down with comedian, actor, and singer Cat Cohen. Cat opens up about having a stroke at 31, navigating health anxiety in the aftermath, and turning one of the scariest experiences of her life into her most fulfilling creative work yet. Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick Audio Engineer: Josh Windisch This episode is sponsored by:  Novartis in neuroscience - Our ambition is to create a transformational impact for people living with severe neurological conditions and their caregivers by discovering, developing and delivering innovative medicines that change the course of disease progression. Jones Road - Use code MESS at https://jonesroadbeauty.com to get a Free Gift with your first purchase! #JonesRoadBeauty #ad   Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.
We Fight For Joy with Kelsey Chittick
2026/09/03
This week on Living With It, Jamie sits down with Kelsey Chittick to talk about losing her husband suddenly, raising two children through grief, and learning to build a life she never expected. They discuss finding humor in the darkest moments, letting go of the life you thought you’d have, the power of community, and how to choose joy. Novartis in neuroscience o Our ambition is to create a transformational impact for people living with severe neurological conditions and their caregivers by discovering, developing and delivering innovative medicines that change the course of disease progression. Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.
There’s No Place Like Home with Annie Meyers-Shyer
2026/09/01
This week, Jamie is joined by her longtime friend Annie Meyers-Shyer, the creator behind This Oak House. They talk about Annie’s unexpected second act, finding a new passion and career at 45, and why it’s never too late to bet on yourself. Annie also shares how she creates a home that feels like an exhale, the small ways our spaces can support us through difficult seasons, and how her home carried her through grief.  Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick Audio Engineer: Josh Windisch This episode is sponsored by:  Novartis in neuroscience - Our ambition is to create a transformational impact for people living with severe neurological conditions and their caregivers by discovering, developing and delivering innovative medicines that change the course of disease progression. Honeylove - Save 20% Off Honeylove by going to https://honeylove.com/messy #honeylovepod ZBiotics - Go to  https://zbiotics.com/messy and use MESSY at checkout for 15% off any first time orders of ZBiotics probiotics.   Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.
The Power of Radical Acceptance with Jim Curtis
2026/08/27
This week on Living With It, Jamie sits down with Jim Curtis, a transformational coach, author, and wellness leader. They discuss how to radically accept the life you have without giving up hope for the life you want, the stories we build around our suffering, and learning to see your body as an ally instead of the enemy. Plus, Jim shares how releasing old beliefs and changing the way we speak to ourselves can open us up to new possibilities.   Novartis in neuroscience o Our ambition is to create a transformational impact for people living with severe neurological conditions and their caregivers by discovering, developing and delivering innovative medicines that change the course of disease progression. Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Podcast reviews

Read MeSsy with Christina Applegate & Jamie Lynn Sigler podcast reviews


4.9 out of 5
3698 reviews
★★★★★
Anelbug2021 2026/10/28
Breast implant illness and false diagnosis
CHRISTINA!!! You need to get your implants out!!! False diagnosis are extremely common when your body is fighting the effects of a foreign object in y...
★★★★★
lucytinker 2026/10/26
I understand
In 2018 I woke up in the night with burning pain in feet , next night burning pain in feet moved up to my face and eyes and hands saw doctor that morn...
★★★★★
Snc4 2026/10/21
Look into..
Hi. After listening to your book months ago, I can’t stop thinking about Keiki (Christina). I felt like you had possibly been misdiagnosed… and now t...
★★★★★
stephhhhhhlllll 2026/10/21
This makes me feel seen
As a mysteriously sick girlie for 10 years, Christina’s journey makes me feel less alone. What a gift for people like me, who get diagnosed, misdiagno...
★★★★★
Qb41 2026/10/21
Please Help Christina!
Please ask Christina to have her implants removed! She has BII. I know because I’ve had the same issues and had them removed! Please! Help her unders...
★★★★★
Ironhorse2180 2026/10/20
Misdiagnosis
Might have Complex Regional Pain Syndrome. It’s what I developed & it is a very PAINFUL DISEASE.
★★★★★
Daryl Lepree 2026/10/20
Living with pain
I’m a long time fan but unfortunately I’m not writing as a fan. I have been misdiagnosed with what I have I live with pain everyday I have the same nu...
★★★☆☆
Cancer/BII survivor 2026/10/20
MS Misdiagnosis
Has anyone discussed breast implant illness with you?
★★★★★
Cpenglert 2026/10/20
Wgs
Hi Christina, thank you for being so open about your experience with MS. I work in diagnostic genomics and wanted to share something you could ask you...
★★★★★
williamjamesferguson 2026/10/19
Christina, you are courageous
I’m going through a lot of pain I have neuropathy. I don’t have MS but Christina your courage has inspired me to endure.
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