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MeSsy with Christina Applegate & Jamie Lynn Sigler

Advertise on podcast: MeSsy with Christina Applegate & Jamie Lynn Sigler

Rating
★★★★★
4.9
from
3528 reviews
This podcast has
99 episodes
Language
English
Explicit
Yes
Date created
2024/03/04
Latest episode
2026/02/03
Average duration
66 min.
Release period
8 days

Description

On this podcast, Christina Applegate and Jamie Lynn Sigler get vulnerable about the curveballs that life can throw…theirs just happens to be MS. Join them each week as they self-reflect, learn, laugh, and grow through their own raw and often-times hilarious conversations with each other, friends, co-stars, and the people that keep them going through the messiness of life.

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Podcast episodes

Check latest episodes from MeSsy with Christina Applegate & Jamie Lynn Sigler podcast


I Can't Worry About Tomorrow
2026/02/03
This week, Christina and Jamie read listener emails and discuss MS fatigue, finding little moments of self care, how to better communicate with friends, and more. Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick Audio Engineer: Josh Windisch This episode is sponsored by: Honeylove - Save 20% Off Honeylove by going to https://honeylove.com/messy #honeylovepod Jones Road - Use code messy at https://jonesroadbeauty.com to get a Free Shimmer Face Oil with your first purchase! #JonesRoadBeauty #ad
Bobbi Brown
2026/01/27
This week, Christina and Jamie are joined by Bobbi Brown. They discuss overcoming obstacles, how to elevate your mood, taking baby steps, and much more.   Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick Audio Engineer: Josh Windisch This episode is sponsored by: Lola - Get 40% off your entire order at https://Lolablankets.com by using code MESSY at checkout. Experience the world’s #1 blanket with Lola Blankets. AG1 - Go to https://DRINKAG1.com/MESSY to get their best offer… get a FREE AG1 Flavor Sampler and AGZ Sampler to try all the flavors, plus FREE Vitamin D3+K2 and AG1 Welcome Kit with your first AG1 subscription order!  Warby Parker - MeSsy listeners get 15% off plus free shipping when they buy two or more pairs of prescription glasses at https://WarbyParker.com/MESSY— using our link helps support the show. #WarbyParker #ad Fatty15 - Fatty15 is on a mission to optimize your C15 levels to help support your long-term health and wellness -Get an additional 15% off their 90-day subscription Starter Kit at fatty15.com/MESSY and using code MESSY at checkout.
I’m a F**king Warrior
2026/01/20
This week, Christina and Jamie read listener emails and discuss Jamie’s recent trip, pregnancy and MS, asking for help, and more. Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick Audio Engineer: Josh Windisch This episode is sponsored by: Wildgrain - Wildgrain is offering our listeners $30 off your first box - PLUS free Croissants for life - when you go to Wildgrain.com/MESSY to start your subscription today. Veracity - For up to 45% off your order, head to https://VeracityHealth.co and use code MESSY  
The Impact of Inflammation with Dr. Will Cole
2026/01/13
This week, Christina and Jamie are joined by Dr. Will Cole, a functional medicine expert. They discuss how to calm inflammation, medical gaslighting, the interactions between all our systems, and much more. Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick Audio Engineer: Josh Windisch This episode is sponsored by: MudWtr - Start your new morning ritual & get up to 43% off your @MUDWTR with code MESSY at  https://mudwtr.com/messy #mudwtrpod Grow TherapyWhatever challenges you’re facing, Grow Therapy is here to help. Sessions average about $21 with insurance and some pay as little as $0, depending on their plan.  Visit https://GrowTherapy.com/MESSY today to get started. 
This Is Not Your Fault
2026/01/06
This week, Christina and Jamie read listener emails and discuss repeat reality stars, being a mother with MS, not blaming yourself, and more. Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick Audio Engineer: Josh Windisch This episode is sponsored by: Honeylove - Save 20% Off Honeylove by going to https://honeylove.com/messy #honeylovepod Jones Road Beauty - Use code Messy at https://jonesroadbeauty.com to get a Free Cool Gloss with your first purchase! #JonesRoadBeauty #ad
There’s a Lot of Unknown in Life
2025/12/30
This week, Christina and Jamie read listener emails and discuss Christmas elves, setting goals, reclaiming your voice, and more. Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick Audio Engineer: Josh Windisch This episode is sponsored by: Calm - Calm has an exclusive offer just for listeners of our show – get 40% off a Calm Premium Subscription at https://calm.com/messy Ridwell - Go to ridwell.com/messy to get $10 off your first pickup or mail-in kit. Because sometimes the best way to do more is just to start with something small that you know makes a difference. Hexclad - Take advantage of HexClad’s Holiday Sale! Head to hexclad.com/MESSY for Up To 50% Off! #hexcladpartner
Are You Mad At Me? with Meg Josephson
2025/12/16
This week, Christina and Jamie are joined by Meg Josephson, author of “Are You Mad at Me?: How to Stop Focusing on What Others Think and Start Living for You.” They discuss the fawn response, how to start healing, the importance of taking a pause, and more.  Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick Audio Engineer: Josh Windisch This episode is sponsored by: ZocDoc - Stop putting off those doctors appointments and go to Zocdoc.com/MESSY to find and instantly book a top-rated doctor today. Wild Grain - Wildgrain is offering our listeners $30 off your first box - PLUS free Croissants in every box - when you go to https://Wildgrain.com/MESSY to start your subscription. iRestore - Unlock your best skin with @iRestorelaser and HUGE savings on the iRestore Illumina Face Mask with code MESSY at https://irestore.com/MESSY #irestorepod Lola Blankets - Lola BlanketsGet 40% off your entire order at Lolablankets.com by using code MESSY at checkout. Experience the world’s #1 blanket with Lola Blankets.
Montel Williams
2025/12/09
This week Christina and Jamie are joined by Montel Williams. They discuss his experience living with MS, bedside manner, why being ill doesn’t make you weak, and more.  Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick Audio Engineer: Josh Windisch This episode is sponsored by: Fatty15 - Fatty15 is on a mission to optimize your C15 levels to help support your long-term health and wellness -Get an additional 15% off their 90-day subscription Starter Kit at fatty15.com/MESSY and using code MESSY at checkout. Tushy - Over 2 Million Butts Love TUSHY. Get 10% off TUSHY with the code MESSY at https://hellotushy.com/MESSY True Classic - Upgrade your wardrobe and save on @trueclassic at trueclassic.com/MESSY #trueclassicpod Ridwell - Head to ridwell.com/messygift. It’s super easy — you can get a digital link to share instantly, or, if you know their address, have a kit mailed straight to your friends and family.  Pro tip: if you’re not using Ridwell yet, treat yourself to one too… maybe that free third one!
We're All Crushing It
2025/12/02
This week, Christina and Jamie read listener emails and discuss perspective, not stuffing your feelings down, journaling, and much more. Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick Audio Engineer: Josh Windisch This episode is sponsored by: Nobl - Don’t miss NOBL’s biggest Sale of the Year! Head to NOBLTravel.com for up to 62% off your entire order! #NOBL #ad Lola Blankets - Get 40% off your entire order at Lolablankets.com by using code MESSY at checkout. Experience the world’s #1 blanket with Lola Blankets. Hollow Socks - For a limited time Hollow Socks is having a Buy 2, Get 2 Free Sale. Head to Hollowsocks.com today to check it out. #Hollow Sockspod Honeylove - Save 20% Off Honeylove by going to honeylove.com/MESSY! #honeylovepod Magic Spoon - Get 5 dollars off your next order at MagicSpoon.com/MESSY. Or look for Magic Spoon on Amazon or in your nearest grocery store. 
How to Feel Safe in Your Body with Deb Dana (Re-Release)
2025/11/25
This week, Christina and Jamie are revisiting their conversation with Deb Dana, LCSW, a clinician and speaker specializing in complex trauma. They discuss how to understand our nervous systems, polyvagal theory, how to feel safe in a body that may feel unsafe, and more. Executive Producers: Christina Applegate, Jamie-Lynn Sigler, and Allison Bresnick Audio Engineer: Josh Windisch This show is sponsored by: Ridwell - Try Ridwell at ridwell.com/messy to get $10 off your first pickup or mail-in kit. iRESTORE -  Illumina Masks:Unlock your best skin with @iRestorelaser and HUGE savings on the iRestore Illumina Face Mask with code MESSY at irestore.com/MESSY! #irestorepod Calm -Calm has an exclusive offer just for listeners of our show– get 40% off a Calm Premium Subscription at calm.com/messy. Honeylove - Save 20% Off Honeylove by going to honeylove.com/MESSY! #honeylovepod Tushy - Over 2 million butts love TUSHY. Get 10% off Tushy with the code MESSY at https://hellotushy.com/messy !
You Don’t Deserve to Feel Guilt
2025/11/18
This week, Christina and Jamie read listener emails and discuss big feelings, reality dating shows, guilt, and more. Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick Audio Engineer: Josh Windisch This episode is sponsored by: Zoc Doc - Stop putting off those doctors appointments and go to Zocdoc.com/MESSY to find and instantly book a top-rated doctor today.  MudWtr - Start your new morning ritual & get up to 43% off your @MUDWTR at mudwtr.com/messy #mudwtrpod Lola Blankets - Get 40% off your entire order at Lolablankets.com by using code MESSY at checkout. Experience the world’s #1 blanket with Lola Blankets. True Classic - Upgrade your wardrobe and save on @trueclassic at trueclassic.com/messy #trueclassicpod iRestore - Unlock your best skin with @iRestorelaser and HUGE savings on the iRestore Illumina Face Mask with code MESSY at irestore.com/messy #irestorepod
Best of MeSsy: Edie Falco, Jean Smart, and Katey Sagal
2025/11/11
This week, we revisit conversations with three incredible guests: Edie Falco, Jean Smart, and Katey Sagal. Executive Producers: Christina Applegate, Jamie-Lynn Sigler, and Allison Bresnick Audio Engineer: Josh Windisch This episode is sponsored by: Ridwell - Try Ridwell at ridwell.com/messy to get $10 off your first pickup or mail-in kit.Hollow Socks - For a limited time Hollow Socks is having a Buy 3, Get 3 Free Sale. Head to Hollowsocks.com today to check out their huge sale. #Hollow Sockspod MudWtr - Start your new morning ritual & get up to 43% off your @MUDWTR at mudwtr.com/messy! #mudwtrpod Honeylove - Save 20% Off Honeylove by going to honeylove.com/messy. #honeylovepod Cozy Earth - Black Friday has come early at Cozy Earth! Right now, you can stack my code MESSY on top of their sitewide sale — giving you up to 40% off in savings. That’s CozyEarth.com, code MESSY
Robert Iler
2025/11/04
This week, Christina and Jamie are joined by Robert Iler, who starred on "The Sopranos" with Jamie. They discuss memories from their time on the show, his path to becoming sober, his friendship with Jamie, and much more. Executive Producers: Christina Applegate, Jamie-Lynn Sigler, and Allison Bresnick Audio Engineer: Josh Windisch This episode is sponsored by: Ridge - Upgrade your wallet today! Get 10% Off @Ridge with code MESSY at https://www.Ridge.com/messy  #Ridgepod Fatty15 - Fatty15 is on a mission to optimize your C15 levels to help support your long-term health and wellness -Get an additional 15% off their 90-day subscription Starter Kit at fatty15.com/MESSY and using code MESSY at checkout. Wildgrain - For a limited time, Wildgrain is offering our listeners $30 off your first box - PLUS free Croissants in every box - when you go to Wildgrain.com/MESSY to start your subscription. Magic Spoon - Get 5 dollars off your next order at MagicSpoon.com/MESSY. Or look for Magic Spoon on Amazon or in your nearest grocery store.  Jones Road - Use code MESSY  at jonesroadbeauty.com to get a Free Cool Gloss with your first purchase! These sell out fast so get them while they last! #JonesRoadBeauty #ad
How Vulnerable Can I Be? with Craig Thomas
2025/10/28
This week Christina and Jamie are joined by Craig Thomas, an author and  Co-Creator, Executive Producer and Writer of How I Met Your Mother. He shares his experience raising a son with Jacobsen Syndrome, discusses the power of storytelling to make people feel less alone, and talks about his new novel, “That’s Not How It Happened.”  Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick Audio Engineer: Josh Windisch This episode is sponsored by: AG1 - Go to drinkag1.com/MESSY to get a FREE Frother with your first purchase of AGZ. Ridwell - Try Ridwell at ridwell.com/messy to get $10 off your first pickup or mail-in kit.Calm - Calm has an exclusive offer just for listeners of our show– get 40% off a Calm Premium Subscription at calm.com/messy.
We Don’t Move Past It, We Move With It
2025/10/21
This week, Christina and Jamie read listener emails and discuss aging, being able to express emotions authentically, where to turn when you’re feeling stuck, and more. Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick Audio Engineer: Josh Windisch This episode is sponsored by: Lola - Get 35% off your entire order at Lolablankets.com by using code Messy at checkout. Experience the world’s #1 blanket with Lola Blankets. GoPure - Get the Tighten & Lift Neck Cream and Sculpt & Tone Arm Cream for 57% off OR get 25% off all other products with code MESSY at gopure.com  #goPurepod iRestore - Unlock your best skin with @iRestorelaser and HUGE savings on the iRestore Illumina Face Mask with code MESSY at irestore.com/messy! #irestorepod ZocDoc - Stop putting off those doctors appointments and go to Zocdoc.com/MESSY to find and instantly book a top-rated doctor today. 

Podcast reviews

Read MeSsy with Christina Applegate & Jamie Lynn Sigler podcast reviews


4.9 out of 5
3528 reviews
★★★★★
Raerae334 2026/02/04
Please don’t ever stop
I don’t have MS but I do live with chronic pain that affects my daily life and relationships. I look forward to each new episode for validation, inspi...
★★★★★
Giminomom 2026/02/03
Only podcast I listen to all the way through.
MeSsy is the bestest of the restest podcast, who knew MS is the thing that can rival every chronic illness I ever heard of?I don’t have MS, only sever...
★★★★★
Stay 5 2026/01/25
Love Messy
I love your show and how honest you both are!
★★★★★
laurie2302 2026/01/20
Very real and relatable
Love your podcast. I appreciate your honesty. I don’t have MS, but I have been “living” with chronic pain (etc) conditions for over 20 years. It ha...
★★★★★
Beige zombie 2026/01/08
Road trip
You two ladies are hilarious and sound like a lot of fun! I’m from Texas, maybe I should go by and pick up Jamie and we can both go hang out with you...
★★★★★
JRM075 2025/12/24
Thank you ❤️
You ladies inspire me, make me laugh, make me cry, and help me process living with MS. I’ve since started my own MS journey Instagram page to share t...
★★★★★
Interplanet Janet B 2025/12/23
Honest
I’m completely enjoying listening to Christina and Jamie, both of whom I watched grow up on tv, be completely open and honest and INTERESTING!!!
★★★★★
Beans13!$rr 2025/12/11
Love you gals can’t wait for your books
Love the podcast cause I love you gals! Good health in 2026!
★★★★★
Brooksxb 2025/12/09
Amazing friendship
The relationship you two have is amazing to watch. You have an understanding that only those that share a common struggle can relate and give such st...
★★★★★
ItsMeJessica_2 2025/12/05
Helpful
Helpful podcast also for people supporting others with chronic pain and other issues. I take away useful information each episode! Love the personal...
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