Advertise on podcast: Biomedical Frontiers: Stories with Innovators in Healthcare

Why do so many promising scientific discoveries never become real medicines? In this episode of Biomedical Frontiers Dr. Mark Esser, Chief Scientific Officer of the Paul and Diane Manning Institute of Biotechnology at the University of Virginia, describes one of the biggest challenges in healthcare innovation: the translational valley of death. Dr. Esser explains how the Manning Institute is being built to bridge the gap between academic discovery and patient-ready therapies. Drawing on decades of experience in industry, he shares how infrastructure, cross-disciplinary teams, regulatory expertise, and new funding models are essential to turning science into medicine. The conversation explores: Why promising biomedical research often stalls before reaching patientsHow the Manning Institute’s Accelerate, Create, Educate (ACE) model is designed to overcome these barriersA real-world case study of a novel sepsis therapy entering clinical trialsWhat this effort means for the future of drug discovery and Virginia’s growing biotech ecosystemFollow Dr. Mark Esser on Social Media LinkedIn: https://www.linkedin.com/in/mark-esser-0b152b2/ Email: [email protected] Paul and Diane Manning Institute of Biotechnology (University of Virginia) https://manninginstitute.virginia.edu UVA Licensing & Ventures https://lvg.virginia.edu/ Resources: Recommended Book: “A Practical Guide to Drug Development in Academia” https://catalog.nlm.nih.gov/permalink/01NLM_INST/vdtut1/alma9916234173406676SPARK Drug Discovery Model (Stanford) https://sparkmed.stanford.eduLove this episode? Follow and write to us: 📸 Instagram: @biomedicalfrontiers 🔗 LinkedIn: https://www.linkedin.com/company/uvacoulter 📧 Reach us: [email protected] Director & Host: Dasha Tyshlek, StratCraft, Inc. www.strat-craft.com Executive Producer: David Chen, Managing Director & Instructor of Engineering Design, UVA Senior Producer: Hannah Moore, Associate Director, UVA Coulter Design Director: Carolyn Wagner, Inc. & Link: carolynwagnerinc.com Produced on behalf of Wallace H. Coulter Center for Translational Research at University of Virginia https://engineering.virginia.edu/centers-institutes/coulter-center-translational-research

When every minute counts, inefficiencies in communication and data flow can cost lives. In this episode of Biomedical Frontiers, trauma surgeon Dr. Jamie Wisser and entrepreneur Robert Holton share how they’re using AI and interoperability to accelerate time to critical care. Dr. Wisser, founder of Actual Healthcare Solutions, describes how his experience performing 26-hour reconstructive surgeries exposed the limits of today’s electronic medical records. Together with Holton, he’s building a platform that connects hospital systems, specialists, and radiologists in real time—using AI to automate referrals, interpret imaging in seconds, and bridge the silos that slow patient care. 💡 What you’ll learn: ✅ Why healthcare still runs on disconnected “data islands” ✅ How AI-driven radiology can deliver results in under 30 seconds ✅ How interoperability can improve patient outcomes and physician efficiency ✅ Lessons from a trauma surgeon turned health tech founder 📚 Resources: Actual HealthCare Solutions: https://www.actualhealthcaresolutions.comHIT Lab: https://www.hitlab.orgNew York Innovation Week: https://www.nyinnovationweek.comFollow Biomedical Frontiers for more: 📸 Instagram: @biomedicalfrontiers 🔗 LinkedIn: https://www.linkedin.com/company/uvacoulter 📧 Reach us: [email protected] Love this podcast? Write to us with feedback or guest recommendations! Production Team: Director & Host: Dasha Tyshlek, StratCraft, Inc. www.strat-craft.com Executive Producer: David Chen, Managing Director & Instructor of Engineering Design Senior Producer: Hannah Moore, Associate Director, UVA Coulter Design Director: Carolyn Wagner, Inc. & Link: carolynwagnerinc.com Produced on behalf of: Wallace H. Coulter Center for Translational Research at University of Virginia

Type 2 diabetes affects over 37 million Americans — but what if our standard treatment paradigm is all wrong? In this episode, Dr. Meagan Grega shares the science and strategy behind lifestyle medicine, a fast-growing movement that uses food, sleep, movement, stress reduction, and social connection to treat and even reverse chronic disease. Dr. Grega is the co-author of the first-ever Clinical Practice Guideline on Lifestyle Interventions for Type 2 Diabetes and a lead author of ACLM’s Expert Consensus Statement on lifestyle medicine in primary care. She co-founded the Kellyn Foundation, where she helps families across Pennsylvania access fresh food, grow gardens, change lifestyle and improve their health together. You’ll learn: How fat in your muscles causes insulin resistance — and how to reverse itWhat makes behavior change stickWhy doctors don’t prescribe lifestyle medicine — and how that’s changingHow community-based programs and school gardens are transforming livesNew Clinical Guidelines and Expert Consensus on treating diabetes with lifestyle interventions📚 Resources: Free CME course: https://lifestylemedicine.org/education-certification/course-catalog/Kellyn Foundation: https://www.kellyn.org/Dr. Grega’s TED Talk: https://www.youtube.com/watch?v=efGa8QD8pU4ACLM Clinical Practice Guideline: https://journals.sagepub.com/toc/ajla/19/2_supplACLM Expert Consensus Statement: Lifestyle Medicine for Optimal Outcomes in Primary Care: https://journals.sagepub.com/doi/full/10.1177/15598276231202970 Follow Biomedical Frontiers for more: 📸 Instagram: @biomedicalfrontiers 🔗LinkedIn: https://www.linkedin.com/company/uvacoulter 📧 Reach us: [email protected] Love this podcast? Write to us with feedback or guest recommendations! Production Team: Director & Host: Dasha Tyshlek, StratCraft www.strat-craft.com Executive Producer: David Chen, Managing Director & Instructor of Engineering Design Senior Producer: Hannah Moore, Associate Director, UVA Coulter Design Director Produced on behalf of: Wallace H. Coulter Center for Translational Research at University of Virginia

Dr. Stanley Crooke pioneered a new class of medicine—antisense oligonucleotides—and built a $5B biotech company, Ionis Pharmaceuticals, to prove it could work. Then he walked away to found a nonprofit, n-Lorem, to treat patients with one-in-a-billion genetic mutations—people no one else would help. In this episode, we explore: What nano-rare diseases are, and why they represent medicine’s next great frontier.The promise of antisense therapy for individualized, mutation-specific treatment.The 30-year scientific journey behind genetic medicine—and what it takes to lead through failure.Why n-Lorem offers a new nonprofit model for treating diseases too rare to commercialize.The privilege, heartbreak, and hope of doing science not just for success, but for purpose.Mentioned Resources: Antisense Technology: A Review (PubMed)n-Lorem FoundationHope Lies in Dreams – Nature’s 10-part series on Dr. CrookeThe National Economic Burden of Rare Disease Study (EveryLife Foundation)Follow Biomedical Frontiers for more: 📸 Instagram: @biomedicalfrontiers 🔗 LinkedIn: https://www.linkedin.com/company/uvacoulter 📧 Reach us: [email protected] Love this podcast? Write to us with feedback or guest recommendations! Production Team: Director & Host: Dasha Tyshlek, StratCraft, Inc. www.strat-craft.com Executive Producer: David Chen, Managing Director & Instructor of Engineering Design Senior Producer: Hannah Moore, Associate Director, UVA Coulter Design Director: Carolyn Wagner, Inc. & Link: carolynwagnerinc.com Produced on behalf of: Wallace H. Coulter Center for Translational Research at University of Virginia

Why Is Your Prescription So Expensive? How Pharmacists Can Help Fix Healthcare 💊 Featuring: Vinay Patel, Pharmacist & Founder of MakoRx Did you know that prescription drugs now account for 40% of healthcare spending on many employer plans? Or that pharmacists were once forbidden from telling you about cheaper alternatives to the medications you take? In this eye-opening episode, pharmacist and healthcare entrepreneur Vinay Patel joins host Dasha Tyshlek to expose the tangled web of middlemen, opaque pricing, and policy loopholes that drive up the cost of care—and to offer real, actionable solutions. Drawing from his experience serving over 15,000 patients through home delivery and launching the cost-plus pharmacy platform MakoRx, Vinay shares: Why drug prices vary wildly—and who really profits from your prescriptionsWhat “gag clauses” were and why they harmed patientsHow subscription-based pharmacy models are changing the gameThe forgotten role of pharmacists in patient-centered careHow employers can save 30–40% on their pharmacy costsWhether you’re a patient, a provider, or a policymaker, this episode is packed with insights on how to untangle the “complification” of our system—and why independent pharmacies could be the future of accessible, affordable care. 📚 Mentioned on the podcast: Unlocking the Value of AI in Healthcare by Dasha Tyshlek: https://www.strat-craft.com/learnwithstratcraft/ai-healthcare-report-info/reportBottle of Lies by Katherine Eban: https://www.harpercollins.com/products/bottle-of-lies-katherine-ebanBooks by Marty Makary: https://www.martymd.com/🔗 Learn more about Vinay Patel: LinkedIn: https://www.linkedin.com/in/vinaypharmd/ Company: https://www.makorx.com/ Director & Host: Dasha Tyshlek, StratCraft, Inc. www.strat-craft.com Executive Producer: David Chen, Managing Director & Instructor of Engineering Design, UVA Senior Producer: Hannah Moore, Associate Director, UVA Coulter Design Director: Carolyn Wagner, Inc. & Link: carolynwagnerinc.com 🎧 Produced on behalf of Wallace H. Coulter Center for Translational Research at University of Virginia https://engineering.virginia.edu/centers-institutes/coulter-center-translational-research 📩 Send feedback or guest ideas: [email protected]

What is it like to live with a rare genetic eye disorder? Join Dr. Abigail Fahim and Dr. Chris Moen as they discuss choroideremia—a progressive retinal disease—and how research, advocacy, and patient experience intersect to push for treatments and improve quality of life. Dr. Fahim shares her cutting-edge research into the cellular mechanisms driving this progressive condition, while Dr. Moen—a physician, patient, and advocate—shares his personal experience with vision loss and the systemic gaps that impact those with rare diseases. Together, they explore: What choroideremia is and how it affects visionHow inherited retinal diseases are diagnosed and why genetic testing mattersThe challenges of developing gene therapies for rare conditionsWhy clinical trials often fail despite promising scienceHow patient advocacy groups like the Choroideremia Research Foundation are driving progressAssistive technology, mobility, mental health, and accessibility for the blind and visually impaired🔬 Dr. Fahim is an Assistant Professor of Ophthalmology at the University of Michigan 🩺 Dr. Moen is formerly the Chief Medical Officer of the Choroideremia Research Foundation and a retired emergency physician Love this podcast? Write to us with ideas, feedback, and guest recommendations at [email protected]. Follow Dr. Abigail Fahim on Social Media Bio & Research Page: https://medicine.umich.edu/dept/ophthalmology/abigail-t-fahim-md-phd Fahim Lab: https://medresearch.umich.edu/labs-departments/labs/fahim-lab Follow Dr. Chris Moen on Social Media LinkedIn: https://www.linkedin.com/in/christopher-moen-2aabb1/ Choroideremia Foundation: https://www.curechm.org/ Mentioned on the Podcast - HYBRD: Website Link : https://www.hybrd.app/ iOS App Store Link: https://apps.apple.com/us/app/hybrd-hybrid-athlete-tracker/id6670271875 Director & Host: Dasha Tyshlek, StratCraft, Inc. www.strat-craft.com Executive Producer: David Chen, Managing Director & Instructor of Engineering Design, UVA Senior Producer: Hannah Moore, Associate Director, UVA Coulter Design Director: Carolyn Wagner, Inc. & Link: carolynwagnerinc.com Produced on behalf of Wallace H. Coulter Center for Translational Research at University of Virginia https://engineering.virginia.edu/centers-institutes/coulter-center-translational-research

How do we tackle the rising epidemic of anxiety with tools that actually scale? Why aren’t traditional therapy models enough? And how can digital technologies like mobile sensing and cognitive bias modification help close the treatment gap in mental health? In this episode of Biomedical Frontiers, host Dasha Tyshlek sits down with Dr. Bethany Teachman, Professor of Psychology and Director of Clinical Training at the University of Virginia, to explore how digital mental health tools are being designed and tested to meet people where they are. Dr. Teachman is the founder of MindTrails, a suite of app-based tools to help individuals reduce anxious thinking, and co-leads the UVA TYDE initiative (Thriving Youth in a Digital Environment). She brings a unique perspective as both a clinician and innovator developing tools rooted in science but built for the real world. Topics Discussed: Why anxiety and depression are rising—and why therapy alone isn’t enoughHow mobile sensing and AI can detect anxiety through physiological, social, and environmental cuesHow MindTrails helps people shift negative thinking patternsWhat it takes to co-develop ethical and effective tech with engineersChallenges of building digital interventions people actually useThe unique value a clinician brings to tech innovationResources Mentioned: 🔹 MindTrails: https://mindtrails.virginia.edu/science.html 🔹 UVA TYDE: https://tyde.virginia.edu/ 🔹 Research Paper: Mobile Sensing and Anxiety Detection 🔹 Research Paper: CBM-I Digital Intervention Preprint Follow Dr. Bethany Teachman: Lab Website: https://teachman.orgEmail: [email protected]: https://www.linkedin.com/in/bethany-teachman-b78558236/Follow Biomedical Frontiers for more: 📸 Instagram: @biomedicalfrontiers 🔗 LinkedIn: https://www.linkedin.com/company/uvacoulter 📧 Reach us: [email protected] Love this podcast? Write to us with feedback or guest recommendations! Production Team: Director & Host: Dasha Tyshlek, StratCraft, Inc. www.strat-craft.com Executive Producer: David Chen, Managing Director & Instructor of Engineering Design Senior Producer: Hannah Moore, Associate Director, UVA Coulter Design Director: Carolyn Wagner, Inc. & Link: carolynwagnerinc.com Produced on behalf of: Wallace H. Coulter Center for Translational Research at University of Virginia

Can medical devices improve patient care in rural healthcare systems? In this episode, Dr. Aileen Helsel, Director of Innovation at Carilion Clinic, shares how her team of engineers works with Carilion’s clinical teams to develop new medical devices that solve unique challenges in rural settings. Rural patients often travel long distances for care - making management of time sensitive emergencies and recurring visits for chronic conditions particularly challenging. Dr. Helsel highlights three projects: a wearable lymphedema therapy device, an early detection system for ventriculoperitoneal shunt failures, and a cardiac surgery arm positioning device. Each of these devices was conceptualized at the bedside (or in the operating room) and brought to life with the expertise and passion of a physician. Dr. Helsel began her career as a research scientist at Washington State University before transitioning to technology transfer in the licensing and ventures team at WSU. She was always looking for a greater impact. Now, as Director of Innovation at Carilion Clinic, she partners with physicians, nurses, and therapists on the front lines to help solve their most pressing challenges. Aileen shares how her team collaborates with a human factors group and a simulation center to test prototypes in realistic settings. Dr. Helsel believes that solving targeted problems in rural healthcare can yield scalable solutions that benefit the broader medical community. Love this podcast? Write to us with ideas, feedback, and guest recommendations at [email protected]. Follow Dr. Aileen Helsel on Social Media LinkedIn: https://www.linkedin.com/in/aileenhelsel/ Carilion Clinic: https://www.carilionclinic.org/ Roanoke Blacksburg Innovation Alliance: https://rbia.tech/ Director & Host: Dasha Tyshlek, StratCraft, Inc. www.strat-craft.com Executive Producer: David Chen, Managing Director & Instructor of Engineering Design, UVA Senior Producer: Hannah Moore, Associate Director, UVA Coulter Design Director: Carolyn Wagner, Inc. & Link: carolynwagnerinc.com Produced on behalf of Wallace H. Coulter Center for Translational Research at University of Virginia https://engineering.virginia.edu/centers-institutes/coulter-center-translational-research

How do groundbreaking biomedical innovations move from research labs to real-world applications? What challenges make healthcare such a complex industry for startups? What risks are worth taking when translating science into impactful solutions? In this episode host Dasha Tyshlek sits down with David Chen, Assistant Dean of Entrepreneurship and Innovation Partnerships, and Lisa Bowers, Director of UVA’s Enterprise Studio and former biotech executive, to explore tech transfer in healthcare. We discuss: Layers of complexity in solving healthcare challengesEconomic realities that make healthcare innovation difficultHow early-stage biotech companies navigate funding, regulations, and clinical trialsLisa and David share insights from their experiences in academia and industry, discussing how researchers can effectively bridge the gap between discovery and commercialization. Resources Mentioned CVille BioHub: https://cvillebiohub.org/Manning Institute: https://manninginstitute.virginia.eduBuilding Better Medicine: https://buildingbettermedicine.comFollow David Chen LinkedIn: https://www.linkedin.com/in/david-c-3889753/UVA’s Wallace H. Coulter Center: https://engineering.virginia.edu/centers-institutes/coulter-center-translational-researchUVA’s School of Engineering and Applied Science: https://engineering.virginia.edu/Follow Lisa Bowers LinkedIn: https://www.linkedin.com/in/lisavbowers/Medium: https://medium.com/@lisavbowersUVA’s Enterprise Studio: https://lvg.virginia.edu/enterprise-studio-1UVA’s Licensing and Ventures Group: https://lvg.virginia.edu/Follow us Instagram: @biomedicalfrontiers LinkedIn: https://www.linkedin.com/company/uvacoulter Production Team: Director & Host: Dasha Tyshlek, StratCraft, Inc. www.strat-craft.com Executive Producer: David Chen, Managing Director & Instructor of Engineering Design Senior Producer: Hannah Moore, Associate Director, UVA Coulter Design Director: Carolyn Wagner, Inc. & Link: carolynwagnerinc.com Produced on behalf of Wallace H. Coulter Center for Translational Research at University of Virginia

Cartilage doesn’t heal easily—but what if it could? In this episode, we sit down with Ben Holmes Ph.D, CEO of Nanochon, to explore how his team is revolutionizing cartilage repair with 3D printing technology. Learn how Nanochon’s innovative material mimics natural cartilage and stimulates proper healing and repair. It may one day make knee replacements obsolete. Ben also shares his leadership journey, how he conducted over 100 physician interviews to help him understand the pain points in orthopedics, and insights on leading technological disruption in medical practices and procedures. Love this podcast? Write to us with ideas, feedback, and guest recommendations at [email protected] Ben Holmes is the CEO driving force behind Nanochon, a company innovating cartilage repair and regeneration. Holmes's expertise in biomedical engineering has positioned Nanochon as a frontrunner in developing next-generation orthopedic medical devices. Nanochon is creating durable, effective treatments for orthopedic patients, promising a future where advanced, reliable solutions are readily available to improve the quality of life for individuals with joint issues. Before founding Nanochon, Dr. Holmes was the CTO at SonoStik, another George Washington University medical device startup.He has a Bachelors of Science degree in mechanical engineering from UVA, and a PhD in Biomaterials and Nanomedicine from The George Washington University. Follow Dr. Ben Holmes on Social Media LinkedIn: https://www.linkedin.com/in/bbhceo/ Check out Nanochon: https://www.nanochon.com/ Read about CVille Biohub's Annual BioSpark Competition: https://cvillebiohub.org/bio-spark/ Learn about NSF's iCorp Program: https://new.nsf.gov/funding/initiatives/i-corps MedTech Innovator is recruiting their next class - apply here: https://medtechinnovator.org/ --------------------------------------------- Director & Host: Dasha Tyshlek, StratCraft, Inc. www.strat-craft.com Executive Producer: David Chen, Managing Director & Instructor of Engineering Design, UVA Senior Producer: Hannah Moore, Associate Director, UVA Coulter Design Director: Carolyn Wagner, Inc. & Link: carolynwagnerinc.com Produced on behalf of Wallace H. Coulter Center for Translational Research at University of Virginia https://engineering.virginia.edu/centers-institutes/coulter-center-translational-research

Genetic sequencing is the process of determining the exact order of the nucleotides in a DNA or RNA molecule. Sequencing provides the complete "blueprint" of an organism's genetic code, and it's a critical tool in genetics, molecular biology, and medical research. Dr. Jonathon Hill develops innovative genomic and bioinformatic methods for gene expression analysis which has tremendous applications in cancer, early detection of chronic diseases, and personalized medicine Love this podcast? Write to us with ideas, feedback, and guest recommendations at [email protected] Dr. Jonathon Hill is an Associate Professor of Cell Biology and Physiology at Brigham Young University and the Vice President of Science & Technology at Wasatch Biolabs. In this episode of Biomedical Frontiers, we dive into the field of genetic sequencing and genomics, how Jonathon built a company from the foundation of a novel gene sequencing technique, his research into congenital heart defects, and the future of the epigenetics field. He is a Fulbright Scholar and a BYU Early-Career Teaching Award recipient, having received his MS in Molecular Biology from the University of Colorado Health Science Center and a PhD in Genetics and Developmental Biology from Columbia University. His company Wasatch Biolabs is working to move epigenetics from the lab to the clinic and his lab at BYU researches the molecular genetics of congenital heart defects by studying development of hearts in embryos. Follow Dr. Jonathon Hill on Social Media LinkedIn: https://www.linkedin.com/in/jonathon-t-hill/ Check out Dr. Jonathon Hill’s work at Wasatch Biolabs: https://www.wasatchbiolabs.com/ Director & Host: Dasha Tyshlek, StratCraft, Inc. www.strat-craft.com Executive Producer: David Chen, Managing Director & Instructor of Engineering Design, UVA Senior Producer: Hannah Moore, Associate Director, UVA Coulter Design Director: Carolyn Wagner, Inc. & Link: carolynwagnerinc.com Produced on behalf of Wallace H. Coulter Center for Translational Research at University of Virginia https://engineering.virginia.edu/centers-institutes/coulter-center-translational-research

What is innovation and why is it important to teach in an engineering program? Innovation has been defined as increasing value, which is increasing the benefits to cost ratio. Because innovation can be an ambiguous concept, it is important to develop a framework to guide the process. Since 2006, Dr. DiMeo has been coaching, consulting, and training processes of innovation, design thinking, and entrepreneurship for medical device innovation and healthcare impact. Love this podcast? Write to us with ideas, feedback, and guest recommendations at [email protected] Dr. Andrew DiMeo is a health innovator, biomedical engineer, design philosopher, and social entrepreneur. He began his career in New York, working on movies and TV shows, most notably The Sopranos. He has a BS in Physics and PhD in Biomedical Engineering and has spent most of his career teaching and practicing health innovation. In this episode of Biomedical Frontiers, we dive into Dr. DiMeo’s time teaching biomedical entrepreneurship at UNC and NC State, the teaching methodology and the philosophy for creating successful translational research classes, a new framework to help organizations innovate, and the future of STEM careers and education. Dr. DiMeo has served as a Team Lead in NIH Programs, including RADx, ITAP, Blueprint MedTech, HIV Point of Care Testing, and C3i. He was previously a Professor of the Practice at UNC & NC State for 12 years where his students started multiple startups including 410 Medical, Contour Surgical, Augment Medical, Novocor Medical Systems, and MEDIC. He was co-founder of Gilero, founder of the NC Medical Device Trade Organization, and founder of CanvasGT, a SaaS startup acquired by Greenlight Guru. Today, you can find him mentoring the next generation of social entrepreneurs, working on his new venture, Hangar Dreys - a co-working concept in Raleigh, NC focused on addressing the loneliness epidemic. Follow Dr. Andrew DiMeo on Social Media LinkedIn: https://www.linkedin.com/in/ajdimeo/ IDEAL Biomedical Publication: https://medium.com/ideal-biomedical Linktree: https://linktr.ee/andrewdimeo Press Release about Springbok Analytics FDA approval: https://www.prnewswire.com/news-releases/springbok-analytics-receives-fda-510k-clearance-for-muscleview-its-ai-muscle-health-analysis-from-a-rapid-mri-scan-302270603.html Director & Host: Dasha Tyshlek, StratCraft, Inc. www.strat-craft.com Executive Producer: David Chen, Managing Director & Instructor of Engineering Design, UVA Senior Producer: Hannah Moore, Associate Director, UVA Coulter Design Director: Carolyn Wagner, Inc. & Link: carolynwagnerinc.com Produced on behalf of Wallace H. Coulter Center for Translational Research at University of Virginia https://engineering.virginia.edu/centers-institutes/coulter-center-translational-research

Microvessels are a crucial part of our body’s circulatory system. They're responsible for delivering the oxygen and nutrients to every cell in your body and are often devastated by diseases like Diabetes and Alzheimer's. Dr. Peirce-Cottler develops computational models and combines them with wet lab experiments to study how tissues heal after injury and to develop therapies for inducing tissue regeneration. Love this podcast? Write to us with ideas, feedback, and guest recommendations at [email protected] Dr. Shayn Peirce-Cottler the is Harrison Distinguished Teaching Professor and Chair of Biomedical Engineering, with secondary appointments in the Department of Ophthalmology and Department of Plastic Surgery at the University of Virginia (UVA). In this episode of Biomedical Frontiers, we dive into the history and future of microvascular research, the observed connection between Alzheimer's and diabetes, and the future healthcare applications of computational modeling. Dr. Peirce-Cottler received Bachelor’s of Science degrees in Biomedical Engineering and Engineering Mechanics from The Johns Hopkins University and her Ph.D. in the Department of Biomedical Engineering at the University of Virginia. She has published over 125 peer reviewed papers and book chapters, is a fellow in both the American Institute for Medical and Biological Engineering College of Fellows (AIMBE) and the Biomedical Engineering Society (BMES). She was awarded the UVA School of Medicine’s Robert H. Kadner Award for Excellence in Graduate Teaching and Mentoring. Her courses in cell and molecular physiology and computational systems bioengineering are foundational to the BME undergraduate and graduate studies at UVA. Follow Dr. Shayn Peirce-Cottler on Social Media LinkedIn: https://www.linkedin.com/in/shayn-peirce-cottler-a70993/ Check out Dr. Peirce-Cottler’s work: https://www.peircecottlerlab.com/ Recent publications from Shayn’s lab: https://www.peircecottlerlab.com/publications Check out Dr. Shannon Barker's page: https://engineering.virginia.edu/faculty/shannon-barker Read about combining synthetic biology, computational modeling, and machine learning to design and build tissues: https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1010701 Director & Host: Dasha Tyshlek, StratCraft, Inc. www.strat-craft.com Executive Producer: David Chen, Managing Director & Instructor of Engineering Design, UVA Senior Producer: Hannah Moore, Associate Director, UVA Coulter Design Director: Carolyn Wagner, Inc. & Link: carolynwagnerinc.com Produced on behalf of Wallace H. Coulter Center for Translational Research at University of Virginia https://engineering.virginia.edu/centers-institutes/coulter-center-translational-research

Investment is critical for advancing promising biomedical research out of the lab and into the hospital. Dr. Tom Skalak has worked widely on innovation ecosystems with the White House, U.S. Congress, and Fortune 500 CEOs and C-suites seeking cultures to advance creative ideation and implementation of innovations. He urges VCs to invest locally with research universities and shares his perspective of some of the most exciting, emerging fields of research. Love this podcast? Write to us with ideas, feedback, and guest recommendations at [email protected] Tom Skalak joined the Joe and Clara Tsai Foundation in 2018 as Senior Advisor to Clara Wu Tsai and was previously the founding Executive Director of The Paul G. Allen Frontiers Group in Seattle, and Vice President for Research Emeritus at the University of Virginia. In these roles, Tom led creative synthesis of research and innovation programs spanning biosciences, environmental sustainability, physical sciences, engineering and technology, arts, design, entrepreneurship, and humanities. In this episode of Biomedical Frontiers, we dive into how small start-ups can grow and thrive in the competitive biomedical technology industry, innovative research in the discipline of protein design and the future applications, and the challenges in studying the emerging fields, human cognition and performance. As Professor and Chair of Biomedical Engineering at UVAs, Tom’s original research included: cardiovascular biomechanics, computational modeling, wound repair, and regenerative medicine, conducted with continuous NIH funding over 28 years. He is a past president of both the American Institute of Medical and Biological Engineering (AIMBE) and the Biomedical Engineering Society (BMES). He was the founder of the UVA-Coulter Foundation Translational Research Partnership and early-stage investment funds with corporate partners such as Johnson & Johnson and AstraZeneca. Follow Dr. Tom Skalak on Social Media LinkedIn: https://www.linkedin.com/in/tom-skalak-81000611b/ Learn more about the Human Performance Alliance: https://humanperformancealliance.org/ Faculty profile: https://engineering.virginia.edu/faculty/thomas-c-skalak The Wu Tsai Institute at Yale: https://wti.yale.edu/ Director & Host: Dasha Tyshlek, StratCraft, Inc. www.strat-craft.com Executive Producer: David Chen, Managing Director & Instructor of Engineering Design, UVA Senior Producer: Hannah Moore, Associate Director, UVA Coulter Design Director: Carolyn Wagner, Inc. & Link: carolynwagnerinc.com Produced on behalf of Wallace H. Coulter Center for Translational Research at University of Virginia https://engineering.virginia.edu/centers-institutes/coulter-center-translational-research

Heart disease is the leading cause of death for men and women in the United States. Mark Hanson co-founded Heartbeat Health to make heart care more consistent and to ensure the patient gets the care when they need it, wherever they are. By transforming how heart care is delivered through technology, the Heartbeat Health team is accelerating access to quality cardiovascular care and improving patient outcomes. In this episode of Biomedical Frontiers, we explore how telemedicine can be a solution to improving quality of care while also reducing cost and dive into how the healthcare industry is changing as more and more providers and insurers are adopting a value based care approach. Mark Hanson is a co-founder, advisor, and former Chief Product and AI Officer at Heartbeat Health, a venture-backed healthcare technology startup focused on delivering tech-enabled cardiovascular care at scale, nationwide. Before starting Heartbeat Health, Mark also founded BeClose, a digital health company that utilized IoT devices and AI-powered services to promote healthy independent living at home, which was merged into Alarm.com, where he served as the head of platforms and health innovations during their IPO. He is a long-time board member of the University of Virginia's School of Engineering and Applied Science Entrepreneurship Advisory Board, an Adjunct Associate Professor at The George Washington University School of Medicine and Health Sciences, and an angel investor and advisor to numerous health tech startups. Follow Dr. Mark Hanson on Social Media LinkedIn: https://www.linkedin.com/in/markhanson/ X: https://x.com/mark_hanson Learn more about Heartbeat Health: https://www.heartbeathealth.com/ Read the summary of “Impact of a Virtual Cardiology Program for Post-Discharge Patients with Cardiovascular Disease: A Randomized Clinical Trial:” https://www.heartbeathealth.com/wp-content/uploads/2023/04/ACC23-3-pager.pdf Director & Host: Dasha Tyshlek, StratCraft, Inc. www.strat-craft.com Executive Producer: David Chen, Managing Director & Instructor of Engineering Design, UVA Senior Producer: Hannah Moore, Associate Director, UVA Coulter Design Director: Carolyn Wagner, Inc. & Link: carolynwagnerinc.com Produced on behalf of Wallace H. Coulter Center for Translational Research at University of Virginia https://engineering.virginia.edu/centers-institutes/coulter-center-translational-research