Advertise on podcast: Atomic Anesthesia

Welcome to the Atomic Anesthesia podcast hosted by CRNA professor Dr. Rhea Temmermand and Co-Founder Sachi Lord. On this show, you'll hear clear, clinically grounded discussions designed for nurse anesthesia residents and CRNAs who want to feel more confident in complex pharmacology, physiology, and real-world anesthesia decision-making. Want more content like this? Become a member of our learning platform. Valvular heart disease feels like a memorization topic, but the table of arrows in every review book isn't random. In Week 2 of our 12-week SEE/NCE series, we show you how two questions (pressure or volume problem, systole or diastole) let you rebuild the hemodynamic goals for every valve lesion in the middle of your exam. In this episode: The shortcut: stenosis is full, slow and tight; regurgitation is full, fast and forwardAortic stenosis: severe AS numbers, the atrial kick, why phenylephrine is the go-to and why CPR rarely worksAortic regurgitation: acute vs chronic, why neuraxial is well tolerated, and the balloon pump contraindicationMitral stenosis: protecting the right heart, avoiding PVR triggers, and why wedge pressure overestimates LVEDPMitral regurgitation: the large v wave and why phenylephrine can worsen the leakA rapid-fire board review of every lesion, plus how to handle mixed valve disease 💜 FREE DOWNLOADS: Grab your copy of customized study plans & worksheets. SEE/NCE Study Plan — a structured, week-by-week plan to pass your boardsNon-Opioid Pharmacology Cheat Sheet — every non-opioid analgesic you need to know, one pageGPCR Cheat Sheet — G-protein coupled receptors decoded for anesthesia 💜 CONNECT: 📥 Email questions, comments or topic suggestions to Rhea or Sachi at [email protected], follow us on social media, and sign up for our newsletter. Mentioned in this episode: 💜 PARTNERS: The Incomologists® https://theincomologists.com/ You work hard caring for others—let us take care of you. Whether you’re a W-2 employee or transitioning to a 1099 role, we understand the unique challenges healthcare professionals face, from insurance coverage to financial planning. That’s where we step in. Like you, we are a team of healthcare providers who understand your needs and help you find tailored insurance plans and financial strategies without the hassle or pressure. And we’re a partner you can rely on, today and in the future. We evaluate all available options and resources in the market to protect our clients, so contact us, and we’ll get started! - Jake Bevilacqua, CRNA ([email protected])

In this premium episode, we’re breaking down pharmacokinetics, the concepts that explain what happens to a drug after it enters the body. From distribution and protein binding to metabolism, clearance, and context-sensitive half-time, we’ll connect the equations and terminology to how anesthetic drugs actually behave in the OR and focus on the high-yield concepts you need to know for the SEE/NCE. In this episode: Volume of distribution, protein binding, and drug distributionClearance, elimination, and half-lifeFirst-order vs. zero-order kineticsHepatic extraction ratio and factors that affect drug metabolismContext-sensitive half-time and continuous infusionsHigh-yield pharmacokinetic concepts for the SEE/NCE This episode is part of our 12-week SEE/NCE podcast series, designed to follow the Atomic Anesthesia SEE/NCE Study Plan week by week. Want to study along with the episode? Join the Atomic Anesthesia learning platform to get the accompanying worksheet, plus access to our members-only podcast episodes and additional SEE/NCE study resources. FREE RESOURCE FOR THIS EPISODE: SEE/NCE Study Plan — A structured, week-by-week plan to pass your boards. Head to atomicanesthesia.com/freebies/see-nce-study-plan to grab it free. WANT THE FULL PLATFORM? Atomic Anesthesia is the all-in-one study platform built specifically for SRNAs: 800 lessons, 10,000 quiz questions, flashcards, and interactive features. Join at atomicanesthesia.com.

In this episode, we’re covering barbiturates and benzodiazepines, two drug classes that both act at the GABA-A receptor but have important differences in their pharmacology, clinical effects, and reversal. In this episode: How barbiturates and benzodiazepines modify the GABA-A receptorWhy barbiturates increase chlo ride channel duration while benzodiazepines increase frequencyMethohexital, thiopental, midazolam, diazepam, and lorazepamKey pharmacokinetic and clinical differences between the major drugsFlumazenil reversal and the board-relevant risks you need to remember This episode is part of our 12-week SEE/NCE podcast series, designed to follow the Atomic Anesthesia SEE/NCE Study Plan week by week. Want to study along with the episode? Join the Atomic Anesthesia learning platform to get the accompanying worksheet, plus access to our members-only podcast episodes and additional SEE/NCE study resources. FREE RESOURCE FOR THIS EPISODE: SEE/NCE Study Plan — A structured, week-by-week plan to pass your boards. Head to atomicanesthesia.com/freebies/see-nce-study-plan to grab it free. WANT THE FULL PLATFORM? Atomic Anesthesia is the all-in-one study platform built specifically for SRNAs: 800 lessons, 10,000 quiz questions, flashcards, and interactive features. Join at atomicanesthesia.com. Mentioned in this episode: 💜 PARTNERS: The Incomologists® https://theincomologists.com/ You work hard caring for others—let us take care of you. Whether you’re a W-2 employee or transitioning to a 1099 role, we understand the unique challenges healthcare professionals face, from insurance coverage to financial planning. That’s where we step in. Like you, we are a team of healthcare providers who understand your needs and help you find tailored insurance plans and financial strategies without the hassle or pressure. And we’re a partner you can rely on, today and in the future. We evaluate all available options and resources in the market to protect our clients, so contact us, and we’ll get started! - Jake Bevilacqua, CRNA ([email protected])

Neuromuscular blockers are packed with high-yield SEE/NCE material and knowing the drug names isn’t enough. In this episode, we break down the pharmacology you need to understand so you can apply it to board-style questions and clinical scenarios. In this episode: Depolarizing vs nondepolarizing neuromuscular blockadeSuccinylcholine pharmacology, contraindications & major complicationsRocuronium, vecuronium & cisatracuriumPseudocholinesterase deficiency & the dibucaine numberFactors that potentiate or cause resistance to neuromuscular blockadeReversal, residual blockade & high-yield board pearls This episode is part of our 12-week SEE/NCE podcast series, designed to follow the Atomic Anesthesia SEE/NCE Study Plan week by week. Want to study along with the episode? Join the Atomic Anesthesia learning platform to get the accompanying worksheet, plus access to our members-only podcast episodes and additional SEE/NCE study resources. FREE RESOURCE FOR THIS EPISODE: SEE/NCE Study Plan — A structured, week-by-week plan to pass your boards. Head to atomicanesthesia.com/freebies/see-nce-study-plan to grab it free. WANT THE FULL PLATFORM? Atomic Anesthesia is the all-in-one study platform built specifically for SRNAs: 800 lessons, 10,000 quiz questions, flashcards, and interactive features. Join at atomicanesthesia.com. Mentioned in this episode: 💜 PARTNERS: The Incomologists® https://theincomologists.com/ You work hard caring for others—let us take care of you. Whether you’re a W-2 employee or transitioning to a 1099 role, we understand the unique challenges healthcare professionals face, from insurance coverage to financial planning. That’s where we step in. Like you, we are a team of healthcare providers who understand your needs and help you find tailored insurance plans and financial strategies without the hassle or pressure. And we’re a partner you can rely on, today and in the future. We evaluate all available options and resources in the market to protect our clients, so contact us, and we’ll get started! - Jake Bevilacqua, CRNA ([email protected])

Carotid endarterectomy is a critical procedure requiring careful management to protect cerebral perfusion, especially during cross-clamping. This episode delves into essential intraoperative considerations, particularly mean arterial pressure (MAP) targets, and strategies to maintain cerebral blood flow through monitoring and potential shunting. Preoperative assessment and baseline establishmentIntraoperative monitoring techniques and A-line importanceMAP target calculation and cerebral autoregulation adjustmentsInduction and maintenance anesthesia specificsStrategies for smooth emergence and minimizing complications FREE RESOURCE FOR THIS EPISODE: SEE/NCE Study Plan — A structured, week-by-week plan to pass your boards. Head to atomicanesthesia.com/freebies/see-nce-study-plan to grab it free. MORE FREE STUDY RESOURCES: Non-Opioid Pharmacology Cheat Sheet — Every non-opioid analgesic you need to know, on one page GPCR Cheat Sheet — G-protein coupled receptors decoded for anesthesia Malignant Hyperthermia Reference Guide — Recognize MH fast. Treat it faster — one-page reference WANT THE FULL PLATFORM? Atomic Anesthesia is the all-in-one study platform built specifically for SRNAs — lessons, quizzes, flashcards, and more. Join at atomicanesthesia.com.

Welcome to the Atomic Anesthesia podcast hosted by CRNA professor Dr. Rhea Temmermand and Co-Founder Sachi Lord. On this show, you'll hear clear, clinically grounded discussions designed for nurse anesthesia residents and CRNAs who want to feel more confident in complex pharmacology, physiology, and real-world anesthesia decision-making. Want more content like this? Become a member of our learning platform: http://atomicanesthesia.com In this episode: Train-of-four basics, including what the twitches actually represent and how to interpret your TOF countTOF count vs TOF ratio, understanding fade, and why four twitches does not necessarily mean full recoveryPost-tetanic count, depth of neuromuscular blockade, and when to use different stimulation patternsUlnar vs facial nerve monitoring, Phase I vs Phase II succinylcholine blockade, and qualitative vs quantitative monitoringUsing TOF to guide neostigmine and sugammadex reversal, plus high-yield SEE/NCE concepts and practice board questions 💜 FREE DOWNLOADS: Grab your copy of customized study plans & worksheets. GPCR Cheat Sheet — The G-protein coupled receptor mechanisms behind the alpha antagonists, beta blockers, and signaling pathways that show up in every OR vasodilator conversation.SEE/NCE Study Plan — A structured plan to help you prepare for the SEE and NCE without burning out — hypertension treatment is a high-yield topic.Non-Opioid Pharmacology Cheat Sheet — Propofol, ketamine, dexmedetomidine, and the rest of the non-opioid sedation toolkit on one page. 💜 CONNECT: 📥 Email questions, comments or topic suggestions to Rhea & Sachi at [email protected], follow us on social media, and sign up for our newsletter. Mentioned in this episode: 💜 PARTNERS: The Incomologists® https://theincomologists.com/ You work hard caring for others—let us take care of you. Whether you’re a W-2 employee or transitioning to a 1099 role, we understand the unique challenges healthcare professionals face, from insurance coverage to financial planning. That’s where we step in. Like you, we are a team of healthcare providers who understand your needs and help you find tailored insurance plans and financial strategies without the hassle or pressure. And we’re a partner you can rely on, today and in the future. We evaluate all available options and resources in the market to protect our clients, so contact us, and we’ll get started! - Jake Bevilacqua, CRNA ([email protected])

Welcome to the Atomic Anesthesia podcast hosted by CRNA professor Dr. Rhea Temmermand and Co-Founder Sachi Lord. On this show, you'll hear clear, clinically grounded discussions designed for nurse anesthesia residents and CRNAs who want to feel more confident in complex pharmacology, physiology, and real-world anesthesia decision-making. Want more content like this? Become a member of our learning platform: http://atomicanesthesia.com In this episode: The three mechanism buckets every OR vasodilator falls into — nitric oxide donors, calcium channel blockers, alpha antagonists — and why the bucket tells you the side effect profile before you ever look up the drugThe full NO → cGMP → PKG → smooth muscle relaxation cascade behind nitroglycerin and nitroprusside, and why one drops preload while the other balanced-dilatesCyanide toxicity and coronary steal with nitroprusside — when to use it, when to cap it, and when to pick something elseClevidipine vs nicardipine vs hydralazine — which drug fits which case, and why hydralazine is falling out of favor for tight OR controlControlled hypotension for neuro cases, afterload management in cardiac surgery, and hypertensive emergencies including aortic dissection and pheochromocytoma 💜 FREE DOWNLOADS: Grab your copy of customized study plans & worksheets. GPCR Cheat Sheet — The G-protein coupled receptor mechanisms behind the alpha antagonists, beta blockers, and signaling pathways that show up in every OR vasodilator conversation.SEE/NCE Study Plan — A structured plan to help you prepare for the SEE and NCE without burning out — hypertension treatment is a high-yield topic.Non-Opioid Pharmacology Cheat Sheet — Propofol, ketamine, dexmedetomidine, and the rest of the non-opioid sedation toolkit on one page. 💜 CONNECT: 📥 Email questions, comments or topic suggestions to Dr. Temmermand at [email protected], follow us on social media, and sign up for our newsletter. 💜 PARTNERS: The Incomologists® https://theincomologists.com/ You work hard caring for others—let us take care of you. Whether you're a W-2 employee or transitioning to a 1099 role, we understand the unique challenges healthcare professionals face, from insurance coverage to financial planning. That's where we step in. Like you, we are a team of healthcare providers who understand your needs and help you find tailored insurance plans and financial strategies without the hassle or pressure. And we're a partner you can rely on, today and in the future. We evaluate all available options and resources in the market to protect our clients, so contact us, and we'll get started! — Jake Bevilacqua, CRNA ([email protected])

Welcome to the Atomic Anesthesia podcast hosted by CRNA professor Dr. Rhea Temmermand and Co-Founder Sachi Lord. On this show, you'll hear clear, clinically grounded discussions designed for nurse anesthesia residents and CRNAs who want to feel more confident in complex pharmacology, physiology, and real-world anesthesia decision-making. Want more content like this? Become a member of our learning platform: http://atomicanesthesia.com In this episode: Exactly how PONV happens in the brain, no vague "vomiting center" hand wavingAll 5 real mechanisms behind how dexamethasone actually stops nausea and vomitingThe practical dosing, timing, and combination strategy that gets the best PONV prevention References: Chu CC, Hsing CH, Shieh JP, Chien CC, Ho CM, Wang JJ. The cellular mechanisms of the antiemetic action of dexamethasone and related glucocorticoids against vomiting. Eur J Pharmacol. 2014;722:48-54.Horn CC, Wallisch WJ, Homanics GE, Williams JP. Pathophysiological and neurochemical mechanisms of postoperative nausea and vomiting. Eur J Pharmacol. 2014;722:55-66.Ho CM, Wu HL, Ho ST, Wang JJ. Dexamethasone prevents postoperative nausea and vomiting: benefit versus risk. Acta Anaesthesiol Taiwan. 2011;49(3):100-104. 💜 FREE DOWNLOADS: Grab your copy of customized study plans & worksheets. SEE/NCE Study Plan — a structured, week-by-week plan to pass your boardsNon-Opioid Pharmacology Cheat Sheet — every non-opioid analgesic you need to know, one pageGPCR Cheat Sheet — G-protein coupled receptors decoded for anesthesia 💜 CONNECT: 📥 Email questions, comments or topic suggestions to Rhea or Sachi at [email protected], follow us on social media, and sign up for our newsletter. Mentioned in this episode: 💜 PARTNERS: The Incomologists® https://theincomologists.com/ You work hard caring for others—let us take care of you. Whether you’re a W-2 employee or transitioning to a 1099 role, we understand the unique challenges healthcare professionals face, from insurance coverage to financial planning. That’s where we step in. Like you, we are a team of healthcare providers who understand your needs and help you find tailored insurance plans and financial strategies without the hassle or pressure. And we’re a partner you can rely on, today and in the future. We evaluate all available options and resources in the market to protect our clients, so contact us, and we’ll get started! - Jake Bevilacqua, CRNA ([email protected])

Welcome to the Atomic Anesthesia podcast hosted by CRNA professor Dr. Rhea Temmermand and Co-Founder Sachi Lord. On this show, you'll hear clear, clinically grounded discussions designed for nurse anesthesia residents and CRNAs who want to feel more confident in complex pharmacology, physiology, and real-world anesthesia decision-making. Want more content like this? Become a member of our learning platform: http://atomicanesthesia.com In this episode: The three decisions that shape every airway plan: awake or asleep, noninvasive or invasive, and preserve or ablate spontaneous ventilationThe most important fork in the algorithm, can you oxygenate or not, and how it sends you down the non-emergency pathway or the emergency pathwayManaging the cannot intubate, cannot oxygenate crisis, including front-of-neck access and the scalpel-bougie-tube technique 💜 FREE DOWNLOADS: Grab your copy of customized study plans & worksheets. SEE/NCE Study Plan — a structured, week-by-week plan to pass your boardsNon-Opioid Pharmacology Cheat Sheet — every non-opioid analgesic you need to know, one pageGPCR Cheat Sheet — G-protein coupled receptors decoded for anesthesia 💜 CONNECT: 📥 Email questions, comments or topic suggestions to Rhea or Sachi at [email protected], follow us on social media, and sign up for our newsletter. Mentioned in this episode: 💜 PARTNERS: The Incomologists® https://theincomologists.com/ You work hard caring for others—let us take care of you. Whether you’re a W-2 employee or transitioning to a 1099 role, we understand the unique challenges healthcare professionals face, from insurance coverage to financial planning. That’s where we step in. Like you, we are a team of healthcare providers who understand your needs and help you find tailored insurance plans and financial strategies without the hassle or pressure. And we’re a partner you can rely on, today and in the future. We evaluate all available options and resources in the market to protect our clients, so contact us, and we’ll get started! - Jake Bevilacqua, CRNA ([email protected])

Welcome to the Atomic Anesthesia podcast hosted by CRNA professor Dr. Rhea Temmermand and Co-Founder Sachi Lord. On this show, you'll hear clear, clinically grounded discussions designed for nurse anesthesia residents and CRNAs who want to feel more confident in complex pharmacology, physiology, and real-world anesthesia decision-making. Want more content like this? Become a member of our learning platform: http://atomicanesthesia.com In this episode: Ten challenging SEE/NCE board questions, one from every corner of the NBCRNA blueprint, each read in full board style with a breakdown of why the right answer wins and why every distractor was built to fool youHigh-yield pharmacology and physiology traps, including Hofmann elimination for the organ-failure patient, shifting the oxyhemoglobin dissociation curve, and the MAC family from MAC-awake to MAC-BARThe clinical-reasoning questions that show up at the bedside, from autonomic hyperreflexia and infant bradycardia to coronary perfusion pressure and reading the capnograph waveformA local anesthetic maximum-dose calculation and a full walk-through of recognizing and treating local anesthetic systemic toxicity 💜 FREE DOWNLOADS: Grab your copy of customized study plans & worksheets. SEE/NCE Study Plan — a structured, week-by-week plan to pass your boardsNon-Opioid Pharmacology Cheat Sheet — every non-opioid analgesic you need to know, one pageGPCR Cheat Sheet — G-protein coupled receptors decoded for anesthesia 💜 CONNECT: 📥 Email questions, comments or topic suggestions to Rhea or Sachi at [email protected], follow us on social media, and sign up for our newsletter. Mentioned in this episode: 💜 PARTNERS: The Incomologists® https://theincomologists.com/ You work hard caring for others—let us take care of you. Whether you’re a W-2 employee or transitioning to a 1099 role, we understand the unique challenges healthcare professionals face, from insurance coverage to financial planning. That’s where we step in. Like you, we are a team of healthcare providers who understand your needs and help you find tailored insurance plans and financial strategies without the hassle or pressure. And we’re a partner you can rely on, today and in the future. We evaluate all available options and resources in the market to protect our clients, so contact us, and we’ll get started! - Jake Bevilacqua, CRNA ([email protected])

Welcome to the Atomic Anesthesia podcast hosted by CRNA professor Dr. Rhea Temmermand and Co-Founder Sachi Lord. On this show, you'll hear clear, clinically grounded discussions designed for nurse anesthesia residents and CRNAs who want to feel more confident in complex pharmacology, physiology, and real-world anesthesia decision-making. Want more content like this? Become a member of our learning platform: http://atomicanesthesia.com In this episode: The cardiovascular, pulmonary, renal, and coagulation changes of normal pregnancy you need to know before you can recognize what's broken in preeclampsiaWhy preeclampsia is fundamentally a placenta problem that becomes a vascular endothelium problem — sFlt-1, soluble endoglin, VEGF neutralization, and the cascade that drives every symptomHELLP syndrome — microangiopathic hemolysis, hepatic involvement, and how it changes your anesthetic planMagnesium sulfate pharmacology — NMDA antagonism, the dosing regimen, toxicity ladder, and why you must cut your non-depolarizing NMB dose by 30 to 50 percentNeuraxial vs general anesthesia in the severe preeclamptic — when neuraxial is safe, how to manage platelet thresholds, and how to blunt the catecholamine surge of laryngoscopy when general is unavoidable 💜 FREE DOWNLOADS: Grab your copy of customized study plans & worksheets. SEE/NCE Study Plan — OB pharm and physiology is high-yield on the exam — this plan tells you exactly where it fits in your prep timeline.Non-Opioid Pharmacology Cheat Sheet — Multimodal pain management options including the non-opioids that show up in OB anesthesia plans.GPCR Cheat Sheet — The receptor pharmacology behind the pressors and antihypertensives you'll be running on these patients. 💜 CONNECT: 📥 Email questions, comments or topic suggestions to Dr. Temmermand at [email protected], follow us on social media, and sign up for our newsletter. 💜 PARTNERS: The Incomologists® https://theincomologists.com/ You work hard caring for others—let us take care of you. Whether you're a W-2 employee or transitioning to a 1099 role, we understand the unique challenges healthcare professionals face, from insurance coverage to financial planning. That's where we step in. Like you, we are a team of healthcare providers who understand your needs and help you find tailored insurance plans and financial strategies without the hassle or pressure. And we're a partner you can rely on, today and in the future. We evaluate all available options and resources in the market to protect our clients, so contact us, and we'll get started! — Jake Bevilacqua, CRNA ([email protected])

Welcome to the Atomic Anesthesia podcast hosted by CRNA professor Dr. Rhea Temmermand and Co-Founder Sachi Lord. On this show, you'll hear clear, clinically grounded discussions designed for nurse anesthesia residents and CRNAs who want to feel more confident in complex pharmacology, physiology, and real-world anesthesia decision-making. Want more content like this? Become a member of our learning platform: http://atomicanesthesia.com In this episode: Why the anesthesia staffing shortage has created one of the strongest job markets ever for new CRNAsWhat chief CRNAs are actually looking for during interviews and how to stand out as a candidateHow to evaluate your first CRNA job based on pay, location, flexibility, autonomy, and most importantly, cultureWhy you have more leverage than you think when choosing a job, plus one simple interview strategy that can make you unforgettable To contact Braden Clark, CRNA you can email him at: [email protected] 💜 FREE DOWNLOADS: Grab your copy of customized study plans & worksheets. SEE/NCE Study Plan — a structured, week-by-week plan to pass your boardsNon-Opioid Pharmacology Cheat Sheet — every non-opioid analgesic you need to know, one pageGPCR Cheat Sheet — G-protein coupled receptors decoded for anesthesia 💜 CONNECT: 📥 Email questions, comments or topic suggestions to Rhea or Sachi at [email protected], follow us on social media, and sign up for our newsletter.

Regional anesthesia is one of the highest-yield, most heavily tested areas on the boards, but most review content buries the clinically useful details under anatomy that never gets asked. This episode breaks down the brachial plexus approaches boards actually tests, the truncal and lower extremity blocks showing up in modern multimodal protocols, and the complication patterns examiners use as answer traps. In this episode: The four brachial plexus approaches and why phrenic nerve risk drops as you move from interscalene to axillaryWhy adductor canal block has replaced femoral nerve block for TKA, and the volume myths that trip up test-takersThe LAST risk hierarchy by injection site, and the Exparel interaction rules boards loves to test FREE RESOURCES: SEE/NCE Study Plan — A structured, week-by-week plan to pass your boards GPCR Cheat Sheet — G-protein coupled receptors decoded for anesthesia. Non-Opioid Pharmacology Cheat Sheet — Every non-opioid analgesic you need to know, on one page Malignant Hyperthermia Reference Guide — Recognize MH fast. Treat it faster — one-page reference WANT THE FULL PLATFORM? Atomic Anesthesia is the all-in-one study platform built specifically for SRNAs — lessons, quizzes, flashcards, and more. Start your free trial at atomicanesthesia.com.

Understanding opioid selection in the OR is all about recognizing pharmacokinetics and how they align with surgical needs and patient factors, rather than focusing solely on receptor effects. This episode explores the five opioids you use most—morphine, fentanyl, sufentanil, remifentanil, and hydromorphone—and offers a framework for choosing optimally among them. Opioid receptor mechanisms and their clinical outcomesLipid solubility's role in opioid kineticsPharmacokinetics of morphine, fentanyl, sufentanil, remifentanil, and hydromorphoneManaging side effects like respiratory depression and opioid-induced hyperalgesiaGuidelines for opioid selection based on case specifics and patient renal function Resources Atomic Anesthesia Platform — In-depth lessons and quizzes on each opioid. FREE RESOURCE FOR THIS EPISODE: GPCR Cheat Sheet — G-protein coupled receptors decoded for anesthesia. Head to atomicanesthesia.com/freebies/gpcr-cheat-sheet to grab it free. MORE FREE STUDY RESOURCES: SEE/NCE Study Plan — A structured, week-by-week plan to pass your boards Non-Opioid Pharmacology Cheat Sheet — Every non-opioid analgesic you need to know, on one page Malignant Hyperthermia Reference Guide — Recognize MH fast. Treat it faster — one-page reference WANT THE FULL PLATFORM? Atomic Anesthesia is the all-in-one study platform built specifically for SRNAs — lessons, quizzes, flashcards, and more. Start your free trial at atomicanesthesia.com. Mentioned in this episode: 💜 PARTNERS: The Incomologists® https://theincomologists.com/ You work hard caring for others—let us take care of you. Whether you’re a W-2 employee or transitioning to a 1099 role, we understand the unique challenges healthcare professionals face, from insurance coverage to financial planning. That’s where we step in. Like you, we are a team of healthcare providers who understand your needs and help you find tailored insurance plans and financial strategies without the hassle or pressure. And we’re a partner you can rely on, today and in the future. We evaluate all available options and resources in the market to protect our clients, so contact us, and we’ll get started! - Jake Bevilacqua, CRNA ([email protected])

A recently identified genetic mutation, passed down on the maternal line, can cause otherwise healthy patients to develop severe and often permanent neurological injury after routine sevoflurane exposure. This episode breaks down the underlying mitochondrial mechanism, why TIVA with propofol is the safer anesthetic strategy, and the family history red flags every provider should be screening for. A newly identified genetic mutation that turns routine sevoflurane exposure into catastrophic, permanent neurological injuryThe mitochondrial mechanism behind it, and why some patients have zero reserve capacity to absorb the hitWhy TIVA with propofol becomes the clear anesthetic choice once you understand what spares Complex I Source: Sanz-Pons J, et al. "Effects of a Mitochondrial Genetic Variant on Sevoflurane Hypersensitivity." Anesthesiology 2026;144:1286–98. FREE RESOURCE FOR THIS EPISODE: GPCR Cheat Sheet — G-protein coupled receptors decoded for anesthesia. Head to atomicanesthesia.com/freebies/gpcr-cheat-sheet to grab it free. MORE FREE STUDY RESOURCES: SEE/NCE Study Plan — A structured, week-by-week plan to pass your boards Non-Opioid Pharmacology Cheat Sheet — Every non-opioid analgesic you need to know, on one page Malignant Hyperthermia Reference Guide — Recognize MH fast. Treat it faster — one-page reference WANT THE FULL PLATFORM? Atomic Anesthesia is the all-in-one study platform built specifically for SRNAs — lessons, quizzes, flashcards, and more. Start your free trial at atomicanesthesia.com. Mentioned in this episode: 💜 PARTNERS: The Incomologists® https://theincomologists.com/ You work hard caring for others—let us take care of you. Whether you’re a W-2 employee or transitioning to a 1099 role, we understand the unique challenges healthcare professionals face, from insurance coverage to financial planning. That’s where we step in. Like you, we are a team of healthcare providers who understand your needs and help you find tailored insurance plans and financial strategies without the hassle or pressure. And we’re a partner you can rely on, today and in the future. We evaluate all available options and resources in the market to protect our clients, so contact us, and we’ll get started! - Jake Bevilacqua, CRNA ([email protected])