Advertise on podcast: The Catalysts

Can a fascination with science fiction fuel life-changing research? If you've followed the career of David Edgell, PhD, then you'll know the answer is a resounding yes. From Star Trek to Blade Runner, the biochemistry professor has spent his career recreating the seemingly impossible health solutions that were promised in fictional far distant futures. Edgell is now exploring the next frontier of gene editing as he pushes the science behind CRISPR-Cas9, the Nobel Prize-winning technology that allows scientists to cut DNA at precise locations. David Edgell, PhD, is a Professor in the Department of Biochemistry at the Schulich School of Medicine & Dentistry. Related links: The Edgell Lab New funding advances precision gene-editing technology Gene editing's next frontier

The future of neurosurgery is bright. That's according to neurosurgeon Dr. Victor Yang, who is combining engineering and medicineto improve patients' lives. Fresh off 24 hours of back-to-back surgeries, Dr. Yang joins The Catalysts to discuss the evolution of technology in neurosurgery, share some of his favourite inventions and provide an intimate look at life in a high-stakes career. Dr. Victor Yang is a Professor of Neurosurgery, Medical Imaging, Orthopaedic Surgery and Medical Biophysics at the Schulich School of Medicine & Dentistry, where he holds the Charles G. Drake Chair in Neurosurgery Research. He was recently elected as a Fellow of the Canadian Academy of Health Sciences. Related links: This is Not a Robot Takeover – Rapport Magazine: https://www.schulich.uwo.ca/rapport//2025/features/this_is_not_a_robot_takeover.html Pioneering research bridges engineering and medicine: https://news.westernu.ca/2022/03/pioneering-research-bridges-engineering-and-medicine/ Life-saving surgery inspires gift to spinal implant research: https://www.schulich.uwo.ca/about/news-events-community/news/2026/life-saving-surgery-inspires-gift-to-spinal-implant-research.html EPISODE CHAPTERS 0:44 – Intro 2:07 – Combining engineering and medicine 6:20 – Unpacking neurosurgery 9:10 – Technology and neurosurgery 12:42 – Dr. Yang's inventions 17:18 – The future of neurosurgery 20:29 – The high stakes of neurosurgery 27:10 – Invention inspiration 29:10 – Dr. Yang's love for London, Ont.

There's power in shining a light on an invisible injury. That's what Dr. Ruth Lanius has heard from the patients she's treated for post-trauma stress disorder (PTSD). Working with civilians, military members, first responders and refugees, the internationally recognized researcher is exploring new and effective ways to treat PTSD. In this episode of The Catalysts, Dr. Lanius shares what she knows about PTSD and what's yet to be discovered. Dr. Ruth Lanius is a Professor in the Department of Psychiatry at the Schulich School of Medicine & Dentistry, Western University. She holds the Harris-Woodman Chair in Psyche & Soma. With Dr. Ruth Lanius MDr. Ruth Lanius is a Professor in the Department of Psychiatry at the Schulich School of Medicine & Dentistry, Western University. She holds the Harris-Woodman Chair in Psyche & Soma.   Related links: Dr. Ruth Lanius' website: https://www.ruthlanius.com/ Dr. Lanius' latest book, Sensory Pathways to Healing from Trauma: Harnessing the Brain's Capacity for Change: https://www.indigo.ca/products/sensory-pathways-to-healing-from-trauma

The health of our planet requires a solution that bridges perspectives, knowledges and people. It's a solution that Nicole Redvers, DPhil, ND, has promoted at regional, national and international levels, working to advocate for the inclusion of Indigenous perspectives in both human and planetary health research and practice. In this episode of The Catalysts, we catch up with Redvers to learn about her prescription for planetary health. Nicole Redvers, DPhil, ND, is a member of the Denı́nu Kų́ę́ First Nation (Northwest Territories, Canada), and is an Associate Professor, Western Research Chair, and Director of Indigenous Planetary Health at the Schulich School of Medicine & Dentistry at Western University. Related links: Indigenous Community & Planetary Health Research Lab Stories of Hope & Strength – Healing Hearts The Science of the Sacred: Bridging Global Indigenous Medicine Systems and Modern Scientific Principles Episode chapters Timing may vary after final edit of podcast. 0:00 – Intro 1:21 – Linking planetary health and human health 3:54 – Understanding planetary health 5:29 – Indigenous Peoples and land stewardship 7:07 – Policy and planetary health 15:27 – Communicating planetary health 19:55 – Bridging knowledge and perspectives 26:50 – Healing Hearts 31:49 – The importance of wellness 36:30 – The future of planetary health

When it comes to predicting your health, the answer often lies in your DNA. That's according to Dr. Rob Hegele, whose life's work has led to numerous breakthroughs for patients combatting cardiovascular disease. In this episode of The Catalysts, we catch up with the 2026 Canadian Medical Hall of Fame inductee to learn about reading DNA, treating high cholesterol, witnessing groundbreaking research and the art of curiosity and discovery. Dr. Rob Hegele is a Distinguished University Professor in the Departments of Medicine (Division of Endocrinology) and Biochemistry at the Schulich School of Medicine & Dentistry. He is a Scientist at the Robarts Research Institute, where he serves as Director of the London Regional Genomics Centre. He is also the holder of the Edith Schulich Vinet Chair in Human Genetics, the Jacob J. Wolfe Distinguished Medical Research Chair in Human Gene Function and the Martha G. Blackburn Chair in Cardiovascular Research. Related links: The London Regional Genomics Centre The Lipid Genetics Clinic Dr. Robert Hegele inducted into the Canadian Medical Hall of Fame Episode Chapters 0:00 – Intro 0:37 – Predicting health with genes 9:19 – On treating high cholesterol 14:59 – The power of genetic diagnoses 17:23 – The birth of statins 21:12 – Theories on cholesterol 26:45 – Dr. Hegele's musical origins 30:12 – The art of discovery 35:50 – The future of cardiovascular disease

For Eric Arts, curing human immunodeficiency virus (HIV) is not a question of how, but when.   One of Canada's leading researchers in combatting HIV joins host Patrick Morley to discuss an equitable approach to treating the roughly 40 million people living with the virus around the world.   Arts also chats about his own in experience in treating HIV in Uganda, as well as the healthy future being promised by Western University's upcoming Pathogen Research Centre.  Eric Arts, PhD, is the Canada Research Chair in HIV Pathogenesis and Viral Control and a Professor in Microbiology & Immunology at the Schulich School of Medicine & Dentistry.  Related resources:   Western leads new international, public-private initiative for equitable access to HIV cure  Western University building one-of-a-kind facility to test how infectious diseases spread  The Arts Lab  Frugal Biomedical Innovations  Listen to The Catalysts on Spotify Listen to The Catalysts on Apple Podcasts Learn more about The Catalysts The Catalysts is produced by Schulich School of Medicine & Dentistry in association with the J. Allyn Taylor International Prize in Medicine — one of Canada's most prestigious medical research prizes.

What if we could teach the immune system to fight cancer? Dr. Carl H. June pioneered the bold ideas behind CAR T-cell therapy, a breakthrough that is transforming cancer treatment and holds the potential to reshape care for millions. In this episode, he reflects on a remarkable career that has spanned the Vietnam War, the HIV epidemic and the rise of modern immunotherapy. He shares how curiosity has driven his work, and why he remains a champion for science in an era when it is increasingly under threat. Dr. June is the 2025 J. Allyn Taylor International Prize in Medicine laureate. With Dr. Carl H. June  Richard W. Vague Professor in Immunotherapy, Department of Pathology & Laboratory Medicine  Director, Center for Cellular Immunotherapies at The University of Pennsylvania  Director, Parker Institute for Cancer Immunotherapy, Perelman School of Medicine at The University of Pennsylvania   Links:  Dr. June: A Global Titan of Cancer Research  Emily Whitehead Foundation  Official Film Trailer: Of Medicine and Miracles

Breast cancer is the most common cancer in Canadian women, with 1 in 8 women facing a diagnosis in their lifetime. It's a complex foe, shaped by biology and lifestyle, made difficult by invasive treatments and cumbersome diagnostic techniques. In this episode, Dr. Ana Lohmann, a medical oncologist and scientist at Western University's Schulich School of Medicine & Dentistry, discusses how this complexity is being met head-on. Her research explores how obesity and metabolism shape cancer diagnosis and recurrence, and how lifestyle, access to care and social inequities influence outcomes. She also discusses emerging tools like liquid biopsies and the growing focus on survivorship and quality of life.    With Dr. Ana Lohmann, MD PhD  Medical Oncologist, Verspeeten Family Cancer Centre Associate Scientist, London Health Sciences Research Institute Assistant Professor, Western University Dept. of Epidemiology & Biostatistics, Dept. of Oncology    Breast Cancer and Obesity Bio Breast Cancer and Diabetes Drugs

Can the trillions of microbes in our gut hold the key to transforming cancer treatment? Through relentless persistence, Saman Maleki, PhD, is pioneering research that uses the gut microbiome and fecal microbiota transplants (FMT) to boost the power of cancer-fighting immunotherapy. In this episode, he shares the science, the challenges, and the hope driving a new frontier in cancer care.  With Saman Maleki, PhD  Associate Professor, Departments of Pathology & Laboratory Medicine, Oncology, and Medical Biophysics, Schulich School of Medicine & Dentistry, Western University  Scientist, Ontario Institute for Cancer Research (OICR)  Scientist, Verspeeten Family Cancer Centre, London Health Sciences Centre Research Institute  Saman Maleki's Poop Pills   FMT Phase 1 Trials  FMT at Work

What if your body already held a secret weapon to beating cancer? Mansour Haeryfar, PhD, is tapping into MAIT cells — a rare type of immune cell that can be supercharged with bacterial molecules to hunt down tumours. His research suggests these cells could form a basis for powerful, universal therapies that work across patients. In this episode, he'll reveal how this cutting-edge science could transform cancer treatment and how the inspiration to fight against malignancy came from an unexpected source.    With Mansour Haeryfar, PhD   Professor, Departments of Microbiology & Immunology, Medicine, Surgery, and Oncology, Schulich School of Medicine & Dentistry, Western University  Scientist, Lawson Research Institute of St. Joseph's Health Care London Past President, Canadian Society for Immunology    Robert Pope: the Artist  MAIT Cells Fighting Cancer Tumors  The Haeryfar Laboratory

Imagine if doctors could send tiny, living medicine straight to a tumor — and then watch it move through the body in real time. That's the work of imaging scientist John Ronald, PhD. From eureka moments, to using firefly genes to track cells, in this episode he tells us how curiosity and creativity are leading to cancer treatment breakthroughs, and opening new frontiers in cancer treatment — one where therapies can be monitored, adjusted, and optimized as scientists track their progress inside the body with unprecedented resolution.     With John Ronald, PhD  Associate Professor, Medical Biophysics Director, Imaging Laboratories, Robarts Research Institute Schulich School of Medicine and Dentistry Western University     John Ronald's Lab Cell Tracking Research Imaging Reporter Genes Monitoring Cell Therapies

When it comes to cancer drug treatments, one size doesn't fit all. That's because our unique genetics determine how our body reacts to certain drugs, which can turn a life-saving treatment into a side-effect nightmare. This is the problem Dr. Richard Kim has spent his career solving. He's championed pharmacogenomics: using genetics to match the right drug to the right patient. His persistence helped make Ontario one of the first provinces to adopt genetic testing that prevents severe chemotherapy side effects, saving lives and reshaping cancer care. In this episode, Dr. Kim explains why "one-size-fits-all" medicine is outdated and how innovations in technology are turbocharging genomics and precision medicine.    With Richard B. Kim MD, FRCPC, FCAHS, FRSC Wolfe Medical Research Chair in Pharmacogenomics Professor of Medicine, Physiology & Pharmacology, and Oncology  Chair, Division of Clinical Pharmacology Department of Medicine Schulich School of Medicine & Dentistry, Western University  Attending Physician, London Health Sciences Centre Scientist, London Health Sciences Research Institute   Personalized Medicine at Schulich  Groundbreaking Drug Testing  Wolfe Medical Research Chair in Pharmacogenomics  Pharmacogenomics in the Clinic

Every cancer journey begins with images—CT scans, MRIs, X-rays. For most of us, they're snapshots that confirm what's already there. But for Sarah Mattonen, PhD, at Schulich School of Medicine & Dentistry, those images hold untold stories. She's uncovering hidden patterns in scans—clues that can reveal if a tumor might come back, or if treatment could cause side effects before patients feel them. With the power of AI, she's turning medical images into roadmaps for truly personalized cancer care. In this episode, we explore how her work is transforming cancer treatment today, and what it means for the future of oncology.  With Sarah Mattonen, PhD   Assistant Professor of Medical Biophysics and Oncology, Schulich School of Medicine & Dentistry, Western University  Scientist, London Health Sciences Centre Research Institute    Cancer Imaging at the Baines Centre  Alumni profile   Paper in International journal of Radiation Oncology, Biology, Physics  Paper in the Journal of Thoracic Disease  Paper in the International Journal of Medical Physics Research and Practice

Cancer can feel like a battle fought in darkness - but what if you could turn on the lights? In this episode, Dr. David Palma, a radiation oncologist and clinician-scientist, explains how he's changing the way patients understand and fight their diagnosis. He's transformed personal loss into a mission to empower patients to become the heroes of their own medical stories. As well, as a leading expert in precision radiotherapy, he'll discuss how he's pushing  the boundaries of how radiation can treat advanced cancers. With a bestselling book and decades of expertise, Dr. Palma will reveal how every patient can turn their cancer diagnoses into a roadmap to hope.    With Dr. David Palma   Professor, Department of Oncology , Schulich School of Medicine & Dentistry, Western University  Radiation Oncologist, Verspeeten Family Cancer Centre, London Health Sciences Centre   Taking Charge of Cancer, by David Palma  Sapiens, by Yuval Noha Harari  Precision Radiation  Bio

Join us as we delve into the groundbreaking work of 2024 Taylor Prize Laureate Professor Rusty Gage, whose landmark discovery transformed our understanding of the brain by showing that humans continue to generate new neurons well into adulthood and even as we age. In this episode, we explore the latest research in the field of neurogenesis and learn how Professor Gage and his team are unlocking innovative approaches to revitalizing the aging brain. We'll also get a glimpse into the inspirations behind his work—from systems theory to intriguing concepts in astrophysics—revealing how these ideas drive his pioneering research in neuroscience.