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Welcome to Chromatography Life, a podcast presented by Waters Corporation. Join us as we dive into the world of chromatography with leading scientists to examine today's critical challenges. As a hub for the chromatography community, we share the lived experiences, passions, and visions of these scientific innovators as they shape the future of analytical chemistry. Hear from experts across a wide range of topics, spanning chromatographic methods, laboratory solutions, column chemistry, and software innovations. Explore problem-solving strategies across issue areas including patient safety, food safety, environmental issues like PFAS, and ways to enhance global wellbeing. We'll also delve into the complexities of regulatory compliance, data integrity, and the evolving landscape of scientific research. We're excited for you to join the community of chromatography experts and enthusiasts. Share your thoughts and the topics you're passionate about; we look forward to hearing from you!

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Check latest episodes from Chromatography Life podcast

Celebrating a year of Chromatography Life Podcast

2025/12/10

In this special Year in Review episode of Chromatography Life, host Neil Lander reflects on a year of engaging conversations with both Waters colleagues and customers from across the analytical science community. Neil shares what made each episode memorable, from deep technical insights to the personal stories behind the science.

Peak Integration in Chromatography – Practical Tips for Smarter Analysis

2025/11/12

In this episode, Neil Lander sits down with renowned analytical chemist Bob McDowall to explore the complexities of chromatographic peak integration. With over 50 years of experience, Bob shares insights into data integrity, regulatory compliance, and the evolving role of manual vs. automated integration. The conversation dives into real-world examples, AI's potential role in chromatography, and best practices for developing scientifically sound SOPs.

Rediscovering Slalom Chromatography – A Forgotten Technique Reimagined

2025/10/07

In our latest episode of Chromatography Life podcast, we explore a fascinating and nearly forgotten separation technique—slalom chromatography—with Dr. Fabrice Gritti, Consulting Scientist at Waters Corporation. Dr. Gritti brings decades of expertise in separation science and shares how this 1980s-era method is being revived to meet today's challenges in DNA and RNA analysis. Dr. Gritti also shares his vision for the future of chromatography, including AI-driven column design and 3D-printed stationary phases.

Adopting AQbD Principles to Method Development

2025/09/09

In Episode 9 of Chromatography Life, we sit down with Richard Verseput, a pioneer in QbD-driven analytical development, to explore how automation, risk assessment, and smart experimental design are revolutionizing chromatography. From cutting-edge tools like Fusion QbD to real-world strategies for building robust, adaptable methods, this episode is packed with insights that can transform your lab's efficiency and precision. Whether you're optimizing LC-MS workflows or navigating regulatory expectations, this is a must-listen for every analytical scientist.

Equilibration Injections Under the Microscope

2025/08/12

Join host Neil Lander as he sits down with Peter Baker, President of Live Oak Quality Assurance and former FDA Investigator of the Year, to explore the complexities of equilibration injections in regulated laboratories. Peter shares his global regulatory experience, offering insights into data integrity, risk management, and how to avoid common compliance pitfalls. This episode is a must-listen for those navigating regulatory expectations in analytical labs.

Tools to Support Enhanced Method Development

2025/07/09

Join host Neil Lander as he sits down with Margaret Maziarz, Principal Scientist at Waters Corporation, to discuss the latest tools and strategic approaches to optimizing method development. Margaret guides us through the advantages to various types of instrumentation, the importance of selecting the right column chemistry, and the powerful capabilities of Empower software. She highlights the critical role of monitoring method performance over time and the challenges of transferring methods between LC systems. For those looking for a quick dose of method development expertise, this episode is a must-listen.

Advancements and Challenges in GLP-1 Peptide Drugs

2025/06/19

This episode of Chromatography Life takes a closer look at the evolving landscape of synthetic peptide drugs - one of the most compelling frontiers in biopharmaceutical analysis. Joining us is Matt Lauber, Senior Director at Waters and a recognized authority in bioanalysis and drug product characterization, who shares both his personal and professional journey, along with his insights into the science shaping today's peptide therapeutics. We discuss the growing significance of GLP-1 peptide drugs, the analytical hurdles they present, and the chromatographic techniques that help ensure their safety and effectiveness. Whether you're already immersed in the world of drug development or just peptide-curious, this conversation provides the right dose of thoughtful perspective on how innovation and precision change are changing the future of human health.

Challenges of Chromatographic Analysis for New Modalities

2025/05/12

Join host Neil Lander on Chromatography Life as he interviews, Arnaud Delobel, R&D and Innovation Director at Quality Assistance. In this episode, Arnaud discusses chromatographic analysis for new modalities, with adeno-associated viruses (AAVs) in the spotlight. He discusses the complexities of analyzing these large biomolecules and the innovative techniques being developed to improve their characterization. Tune in to glimpse the future of chromatography and learn about the incredible advancements that are helping to tackle some of the toughest human health challenges.

Automating Dissolution in the Laboratory

2025/04/13

Join host Neil Lander on Chromatography Life as he interviews Ben Calvopina, Application Scientist and expert in dissolution testing at SOTAX. Ben shares his journey from service engineering to leading automation projects, highlighting the impact of automation on efficiency and accuracy in pharmaceutical quality control. The episode explores the practical aspects of automating dissolution methods and the importance of validation to ensure reliable results. Tune in to this episode to learn about the latest trends and future directions in chromatography and dissolution.

The Evolution of UPLC Columns

2025/03/17

In this episode of the Chromatography Life podcast, our host Neil Lander sits down with Tom Walter, a corporate fellow at Waters, to explore the fascinating journey of UPLC column evolution. Tom, a seasoned expert with numerous patents and innovations under his belt, shares his experiences and insights from his extensive career in chromatography. From the early days of large particle columns to the cutting-edge small particle technology of today, Tom discusses the challenges, breakthroughs, and environmental impacts of UPLC advancements. Join us for an engaging conversation that sheds light on the past, present, and future of chromatography with one of the field's most respected leaders.

Validating Chromatographic Methods: Challenges, Tools, and Optimization

2025/02/02

Join host Neil Lander as he welcomes Katy Rhynard, Associate Director of Laboratory Informatics at Gilead Sciences. In this episode, Katy discusses the intricacies of validating chromatographic methods, including guidelines and regulatory requirements, key success metrics, documentation, techniques, and tools. Katy details the pervasive challenges in method validation, and how to effectively leverage tools in Empower to optimize stages throughout the process. Katy guides us through the steps to upgrade our lab's method validation processes and shares how Empower's Method Validation Manager supports lab teams in their calculations and compliance, so they can truly 'focus on the chromatography'.

Enhancing Detection via Multi-Angle Light Scattering in Size Exclusion Chromatography

2025/01/05

In this episode of Chromatography Life, we're joined by Andy Meyer from Wyatt Technology to explore the tech, applications and challenges of leveraging Multi-Angle Light Scattering with Size Exclusion Chromatography (SEC). Andy delves into the intricacies of SEC, discussing columns, standards, and the innovative techniques that are enhancing detection and deliverables. Get an insider's perspective on this impactful combination and the fascinating work being done in the field.

Welcome to Chromatography Life: A Waters Podcast Series

2024/10/18