
Advertise on podcast: DDT Method Podcast — Peptides, Performance Enhancement and Advanced Protocols with Drew Donaldson
Rating
5from
This podcast has
101 episodes
Language
EnglishExplicit
No
Date created
2025/02/28
Latest episode
2026/10/21
Average duration
74 min.
Release period
6 days
Description
DDT Method Podcast is for serious athletes and advanced lifters who want accurate information on compounds, protocols, fat loss, and the performance strategies that actually deliver results. Drew Donaldson has spent years coaching serious athletes at every level, building protocols from the ground up alongside the practitioners, researchers, and competitors doing the same work. If you're serious about performance enhancement and want advice from someone operating at this level, this is your show. Topics include: peptides, hormone optimization, performance enhancement biohacking and training.
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Check latest episodes from DDT Method Podcast — Peptides, Performance Enhancement and Advanced Protocols with Drew Donaldson podcast
My Current Stack: What I Run as a 41 Year Old Performance Enhancement Coach
2026/10/21
Nationwide Bloodwork, no doctor visit → https://ddtmtd.co/AmplifyReliable, third-party tested research compounds: Janus Optimize Code DDTSkoolJoin my Enhancement Education Community → https://ddtmtd.co/skoolHire me as your coach → https://ddtmtd.co/apply
A month and a half ago my heart started skipping beats, and after an EKG, an ER visit, and a cardiologist, the answer was stress, not PEDs.
Nothing was wrong with my heart.
Everything was wrong with how I was running my life.
So this is the first solo episode of the DDT Method Podcast, and it's the whole plan that came out of it. The training, nutrition and… all the compounds I’m taking and what I’m leaving behind.
About me: I'm Drew Donaldson, founder of DDT Method. I spent fifteen years as a pro wrestler including time in WWE developmental, I ran MI40 Gym as head trainer and general manager under Ben Pakulski, and have been using peptides since 2010. I coach, I run the DDT Method School Group, and I'm in a lifelong argument with absolutist fitness advice.
5 Key Takeaways
The three things that were wrong when my heart started skipping beats, and none of them was my heart.Why a calcium score of zero at 38 didn't let me off the hook, and the test that finds what it can't.The two blood markers most guys on gear have never heard of, and the one that should keep you off steroids entirely if it's high.The announcement: my testosterone dose for the rest of my life, and why I'm done with everything above it.How to use fat loss tools by the day instead of by the cycle: which days get BAM15, which get ATX-304, and why they never overlap.
Chapters
0:05 First solo episode: what this is2:22 A thousand right ways, a million wrong ways4:41 Comic books, WWE developmental, 250 pounds, and MI409:08 Why I learn the mechanism: ATP, ROS, AMPK, mTOR15:29 The goal: the biggest 200 pounds humanly possible18:30 The heart scare: skipped beats, stress, a gallon of sweat a day24:16 Thick blood, and the EKG with the leads on backwards27:30 Calcium score zero at 38, and why that's not enough31:05 ApoB and Lp(a): the numbers guys on gear don't know35:29 Soft plaque, the contrast scan, the echo, and the Holter38:40 Phase one: macros, water, four hypertrophy sessions42:14 Steps, four cardio sessions, weighted vests, two HIIT sessions46:33 Norwegian 4x4s and the four functional sessions51:00 Hematocrit management and daily injections53:14 The announcement: replacement dose for life, nothing anabolic on top56:40 Taurine, TUDCA, senolytics, and the mitochondrial stack1:03:30 Tirzepatide over retatrutide1:04:11 SS-31: an Iron Man suit for the cell1:09:00 Plasmalogens, omegas, carbon 60, glutathione, BPC and TB-5001:13:01 Bioregulators: Thyrogen, Chelohart, Livagen, Vesugen1:14:30 The problem with 23-year-old educators1:18:30 Tesamorelin and the start of the fat loss phase1:20:40 MBD1 and the futile creatine cycle1:24:21 BAM15, DNP, and ATX-304: tools by the day, not by the cycle1:30:58 Epitalon, and FLGR-242 as the January finisher1:34:30 The tech: multi-wave oscillator, PEMF, CO2, red light, face plunge1:39:53 You can do cool shit without the hardcore levers1:42:20 Coaching, consult calls, and the School Group
If It Hurts, Stop: Why Strength Training Breaks Men Down After 40 | Joe DeFranco
2026/10/14
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If it hurts, stop doing it. That's Joe DeFranco's advice for every man over 40 who's still training like he's 25, and he says he could end the podcast right there. We're glad he didn't, because the next hour is the system behind the most famous rebuild in strength and conditioning: Triple H at 40, body breaking down, one injury after another, willing to trade his physique for function. Joe told him he'd look the same or better. Three months without a heavy back lift, face pulls and band pull-aparts instead of 150-pound dumbbell rows, and his tailor measured his upper back bigger. Sixteen years later they still train together. On this episode of the DDT Method Podcast Drew gets the whole method: no mandatory exercises, upper/lower over the bro split, unilateral lower body, and relative-strength goals like a weighted push-up 10RM that you can't improve while carrying extra body fat.
5 Key Takeaways
The one piece of advice Joe says could end the podcast, and why most men over 40 ignore it every time they lift.Why Joe would make every online coach train people in person for five years first, and the one-in-fifty problem research can't solve.The exact changes that rebuilt Triple H, including the three months his tailor noticed before he did.The bodyweight above which every one of Joe's health markers goes bad, and the mindset shift that got him under it at 51.The weekly template for being good at everything: how many lifts, how many steps, how much zone 2, and the only HIIT session you need.Chapters
0:00 Where men over 40 are dropping the ball0:47 If it hurts, stop: listen to your body, not the internet4:03 From a 500-square-foot storage closet to the New York Giants9:44 Train people in person for five years before you coach online18:38 Joe's transformation at 40: satisfied not full, 7.5/10 workouts, move more23:18 What goes wrong in your 40s even when you do everything right26:16 Bigger is not better after 40: leaner and stronger30:18 Good at everything: the pro wrestler problem33:48 No mandatory exercises: concurrent programming and relative-strength goals43:32 How Joe rebuilt Triple H: three months without a heavy weight53:07 The upper/lower split, two-minute mobility, and the unused home gym1:00:35 Cardio: don't start with Norwegian 4x41:04:48 The weekly template: lifts, steps, zone 2, and one HIIT session1:07:01 Where to find Joe
Connect with Joe DeFranco
Instagram – https://www.instagram.com/defrancosgym/
Website – https://www.defrancostraining.com
YouTube – https://www.youtube.com/joedefranco
Podcast – The Industrial Strength Show
Look Like You Lift: Mitochondria, Peptides, and the Training System Behind Both
2026/10/07
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You have peptide fatigue. We love PEDs, peptides, and small molecules as much as anyone, and we've watched the space go from hunting for Masteron to every person with a phone taking 87 things for every condition they think they have. So on this episode of the DDT Method Podcast Drew brings in Braydon Barrett, a strength coach of 13 years who studied pharmacodynamics and biochemistry on top of exercise physiology, and asks him which peptides are the real needle movers. Braydon answers with a question: what's your biological bottleneck? Because for most people it isn't a peptide. It's the mitochondria, and the things that build mitochondria are the things you're skipping. Two hard cardio sessions a week on top of heavy lifting. Heat. Sleep, which he calls the biggest mitochondrial uncoupler we have, and it's free. MOTS-c and 5-Amino-1MQ sit at the very bottom of his list. Peptides are the essential amino acids. Training is the steak.
5 Key Takeaways
The one question Braydon asks before he'll name a single peptide, and why most people's honest answer isn't a peptide at all.His ranked list for building mitochondria, from the thing no supplement can touch down to where MOTS-c and 5-Amino-1MQ actually land.The engine analogy that finally separates biogenesis, mitophagy, and efficiency, and which one you need right now.The four-block training system behind Look Like You Lift, and the one macro that moves with every block.The number Braydon checks before your body weight in a fat loss phase, and what he does the morning it drops.
Chapters
0:00 Peptide fatigue: when everyone with a phone can buy anything1:21 Why peptides are the future of medicine, and the counterfeit problem4:31 A 13-year overnight success: strongman, powerlifting, Look Like You Lift9:33 Rigidity in training creates rigidity in thinking13:07 Start with the biological bottleneck, not the peptide17:08 The best-case peptide candidate: lean, optimized, and still wants more17:50 Mitochondria are not just the powerhouse of the cell19:25 What actually builds mitochondria (and where MOTS-c lands)23:56 Peptides are the amino acids, training is the steak24:51 The V8 engine: more cylinders, cleaner fuel, better firing30:29 Reactive oxygen species: redlining the electron transport chain34:13 The Look Like You Lift system: four training blocks40:45 Why dedicated blocks beat doing everything at once42:16 Carbs are the lever that moves with each block48:06 Your body is a thermostat, not a calculator51:20 Waking body temp: the number that gives you permission to push57:29 Cardio: two hard sessions a week, zone 2, and the HIIT you're not doing1:05:36 Where to find Braydon
The #1 Peptide Mistake According to a Doctor on the FDA's Peptide Panel| Gabriel Alizaidy, MD
2026/09/30
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You're collecting peptides like Pokémon. That's Dr. Gabriel Alizaidy's diagnosis in the first ninety seconds of this episode of the DDT Method Podcast, and the next hour is the cure: pick the right tool for the right job, run one or two things at a time, dose low and slow, and let someone who isn't you make the call. Drew's intake forms went from three entries to forty-seven. Both of them have been guilty. Nobody gets to feel superior here.
The section people will replay is mitochondria. SS-31 is physical therapy for your mitochondria. MOTS-c is exercise. Run them in the wrong order and you get the pattern Gabe sees constantly: two great injections, then tired all the time. He explains mitochondria the way he'd explain them to his mom (miles per gallon, exhaust, scrap the broken car), why diet, sleep, and training come before anything goes in a syringe, why MOTS-c works better with exercise instead of replacing it, and the MOTS-c doses he won't touch. Then the wide-angle stuff: red light therapy and nitric oxide, oxytocin as the peptide he uses before public speaking, myostatin inhibitors and FLGR from a safe distance, how Drew finds new compounds before they hit Instagram, why phase 3 trials for BPC-157 and TB-500 aren't coming, and the decision-fatigue conversation that lands where wealthy people already live: get an advisor for this part of your life. First peptide or fifteenth, this is the episode about how to choose.
About the guest: Dr. Gabriel Alizaidy (MD; MS in Precision Health, University of Chicago) came up through CAR-T cancer research at UChicago, runs clinical R&D for a performance-medicine telehealth company, and sat on the FDA's Pharmacy Compounding Advisory Committee that voted this summer to move BPC-157, TB-500, KPV, and MOTS-c toward compounding pharmacies.
5 Key Takeaways
The one-line diagnosis an FDA panel doctor gives for how most people use peptides.Why SS-31 is physical therapy and MOTS-c is exercise for your mitochondria.The number of compounds Drew is actually running right now, even though he has vials of everything.Why phase three trials for BPC-157 and TB-500 aren't coming, and what a clinical researcher says should stand in for them.The reason Gabe says even a knowledgeable person shouldn't build their own stack, and the kind of advisor he thinks belongs in your corner.
Chapters
0:00 Welcome, and how to work with DDT Method1:24 The #1 peptide mistake: collecting like Pokémon3:13 Who Gabe is: CAR-T research, telehealth R&D, and the FDA peptide panel8:17 The new fat-loss compounds, and why he won't rush them12:53 Mitochondria explained: miles per gallon and exhaust16:59 The non-negotiables before you inject anything20:24 SS-31 is physical therapy, MOTS-c is exercise: which comes first22:58 A word from Amplify Wellness and Janus Optimize25:33 Low and slow: the doses he won't touch28:30 Folate, AMPK, and cardiolipin: what the two peptides actually do33:04 Red light therapy and nitric oxide38:08 Oxytocin: the peptide for public speaking and connection42:52 Myostatin inhibitors and FLGR: watching, not touching47:55 A word from Amplify Wellness, Janus Optimize, and the Skool group50:09 How Drew finds new compounds, and why RCTs aren't coming55:56 Less is more: Drew's medicine cabinet confession1:00:32 Decision fatigue: put the call in an expert's hands1:06:42 Where to find Gabe
Connect with Dr. Gabriel Alizaidy
Instagram – @gabrielalizaidy
LinkedIn – https://www.linkedin.com/in/galizaidy/
YouTube – https://www.youtube.com/channel/UCiOE4LyFDVoSuQLSLX7SM8A
Why You Can't Focus, Sit Still, or Enjoy Anything Anymore (It Might Not Be ADHD)
2026/09/23
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Jake Benson is back on the DDT Method Podcast for round three, and it opens on a question a lot of you have sent in: why does kratom (or THC, or the third energy drink) stop working, and why is it so hard to stop?
Jake breaks down what's actually going on under the hood: dopamine as a value scale that tags what's worth remembering, why a substance you rely on is really "paying the withdrawal cost" for you, the kappa-opioid and dynorphin drag that makes the benefit slide under the cost, and why two people on the exact same dose need completely different protocols.
5 Key Takeaways
Why a substance you rely on is "paying the withdrawal cost" for you, and the signal Drew uses to know when kratom has stopped being worth it.The first question Jake asks anyone who wants to quit THC, and why skipping it is the reason most attempts fail in the first uncomfortable week.Why the supplement that changed your life will give someone else diarrhea, and what that says about every generic dopamine protocol.The six different reasons people procrastinate, and why "low dopamine" is almost never the right label for any of them.The single cost Jake removes from a stimulant-dependent entrepreneur's day, and how his own schedule does it without cutting the caffeine first.
Chapters
0:00 Cold open: the substance pays the withdrawal cost1:59 Drew's kratom case study: why it stops working9:29 THC, "not addictive," and why there's no THC protocol14:13 How to actually quit: intent, gatekeepers, and the replacement routine18:54 No magic supplement: the magnesium story, 9-MeBC, bromantane22:07 Transcendence: the app Jake is building24:48 A word from Amplify Wellness, Janus Optimize, and DDT coaching26:25 Dopamine, undressed: what it actually does31:23 The dopamine tax: news, social media, and why you were supposed to be bored35:58 Decide what's yours to care about, and the Brick39:18 Weaponizing dopamine: intent, procrastination, quiet moments44:39 The six causes of procrastination49:33 The entrepreneur avatar: stimulants, the transition tax, and Jake's 2:30 AM schedule58:20 A word from Amplify Wellness, Janus Optimize, and the Skool group1:01:42 Euphoria: the four layers of a pre-workout1:13:04 Wrap-up and where to find Jake
Connect with Jake Benson
Instagram – https://www.instagram.com/jakeyb_43/
Better Through Biology – https://www.betterthroughbiology.com
The 5 Foundations Every Peptide Protocol Needs Before They Actually Work | Jay Campbell
2026/09/16
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Big Pharma just came for retatrutide. Eli Lilly filed six lawsuits against research peptide sellers, a med spa chain, and a compounding pharmacy, compounders got cut off from tirzepatide and semaglutide, and a biologics classification is coming that would make Lilly the only place to get reta. Jay Campbell is back on the DDT Method Podcast to break down who Lilly is targeting and why, what a biologic classification does to generics and compounders, why renaming your GLP-3 isn't a workaround, how Lilly let the research market do its marketing for free for three years, and why the play now is four- and five-pathway agonists and oral delivery, starting with BioLean 4XR, the oral strip BioLongevity Labs is building to replace what Lilly took off the table.
5 Key Takeaways
The one question Jay asked a stranger who had lost 60 pounds on retatrutideWhat a year of DEXAs and full-body scans on FLGR-242 users showed about the organ-growth Why Eli Lilly waited three years to act on retatrutide, and what a biologic classification means for RUOJay’s six-day experiment on SLU-PP-915 vs high-dose SLU-PP-332The line between sharing your protocol and making a claim for influencers
Chapters
0:00 Foundation before enhancement: Jay's new book and the 54-year-old on reta9:47 FLGR-242 one year in: what it is, what it fixed, and what users are seeing18:35 Non-responders, why DEXA misleads, and how to dose FLGR-24224:29 How albumin binding made FLGR-242 possible, and Drew's upcoming log33:08 Bio-IGF: the once-a-week IGF product coming next38:00 Clotho for the already-optimized: senses, sexual performance, and the kidney trial44:54 Grounding, sunlight, melanotan, and Drew's foundation reset50:31 Big Pharma just killed retatrutide: Eli Lilly, biologic classification, and BioLean 4XR58:59 The six lawsuits, 14,000 websites, and compounders cut off1:06:22 The influencer legal line: what you can and can't say1:11:46 SLU-PP-915 vs high-dose SLU-PP-332: the verdict1:18:23 ATX at high dose, high-dose SS31, and the BioRecharge stack1:24:28 MOTS-c protocols and phasing AMPK against mTOR1:29:16 The future of delivery: patches, sprays, and the black market risk1:36:00 Living Leaner, Longer, Stronger and where to find Jay
Connect with Jay Campbell
Website: https://jaycampbell.com
Living Leaner, Longer, Stronger on Amazon: https://www.amazon.com/dp/B0HDJ41BWS
Fully Optimized Health (private membership): https://jaycampbell.com/foh/
Instagram: https://www.instagram.com/jaycampbell1971/ (
X: https://x.com/JayCampbell333
Substack: https://substack.com/@jaycampbell333
Case Study: Dissecting a Pro Card Winning Prep | Coach Mike Nassif & Chris Gross
2026/09/11
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Chris Gross stepped on stage at the Tampa Pro the leanest he's been since 2018 and the best he's ever looked, and he did it eating 6,000 to 7,000-calorie refeeds up to twice a week. In this episode of the DDT Method Podcast, Drew sits down with Chris and his coach Mike Nassif to break down the contest prep that made it work: why your peak offseason intake should be your refeed day from week one, how high days keep T4 to T3 conversion and free T3 from tanking in a calorie deficit, and why the frequency of those days should go up, not down, as you get leaner. If you've ever stalled in a fat loss phase and blamed metabolic adaptation, this is the mechanism explained by people who manage it for a living.
This isn't just for bodybuilders. Anyone chasing extreme fat loss, whether that's a contest prep, a photoshoot, or just getting truly shredded, will get a repeatable framework here: how to structure refeed days when cutting, why hunger is the signal your diet is working, when a coach introduces a GLP in prep and why not at the start, how to manage fatigue without seven days of cardio, and what the blood work looked like three weeks out and one week post-show. The back half covers the health side of enhancement: the diagnostics Mike requires for his athletes, how to get an echocardiogram and calcium score without a fight, and the blood pressure protocol Drew wishes every client followed.
5 Key Takeaways
The refeed rule a pro coach uses to keep the metabolism from downregulating in prep.What "metabolic downregulation" actually looks like on a blood panel.Why zero stress mattered as much as the diet, and what Mike tells athletes who can't just switch it off.When to bring a GLP into a prepThe diagnostics Mike requires for enhanced athletes.
Chapters
00:00 Contest prep from a different angle
02:41 The order: 6 to 7,000 calories after six high-carb meals
05:27 Why it didn't break thermodynamics
06:22 Mike's high-day rule: your offseason intake is your refeed
09:22 What metabolic downregulation actually means
10:56 T4 to T3, free T3, and allostatic load
12:52 Zero stress: the other half of the result
14:18 How Chris actually de-stressed
16:30 Coaching athletes who can't just "have fun"
18:25 What changed this prep vs. every prep before
19:54 Stair stepper over treadmill, and the 8-to-5-weeks-out protocol
22:51 Managing fatigue and the timeline Chris kept breaking
26:14 Coach-client communication as a performance variable
28:14 Drew's guardrail: this only works between two professionals
33:37 Peptides in contest prep: what Mike actually uses and when
37:05 Dosing, recovery, and a sponsorship handshake
38:42 Drew's 20-day experiment and inflammatory markers
40:10 Why Chris's hunger came back at higher doses
42:18 Why Mike keeps hunger present on a GLP
44:28 Post-show: back to baseline weight before the reverse
45:29 The blood work: best of Chris's career, three weeks out and one week after
48:48 The peak cycle, on the record
49:36 Clearance time, health supplementation, and doing the little things
53:12 Drew gives Chris his flowers: continued education
55:08 Bioregulators: Chris's two-compound self-experiment
57:47 Calcium scores, echocardiograms, and where to get them cheap
59:52 Mike's required diagnostics for enhanced athletes
01:02:24 Blood pressure: how, how often, and which cuff
01:05:05 Tracking BP with a wearable
01:06:18 Educate yourself, monitor your health
01:08:04 Where to find Chris and Mike
Connect with the Guests
Chris Gross
Instagram: https://www.instagram.com/chrisjohn___/
NeoGen Labs
Mike Nassif
Instagram: https://www.instagram.com/mike_nassif/
Email: [email protected]
The System Behind WWE's Best Physiques: Train Less, Eat More & Recover Harder | WWE Physique Coach
2026/09/09
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Description
Half the WWE roster is in the best shape of their lives and the internet has one question: what are they doing? Jay Ferruggia is the common denominator. He coaches CM Punk, Rey Mysterio, Chad Gable and a who's who of WWE, MLB, NFL and UFC athletes, wrote the Men's Fitness Hardgainer column for a decade, and has spent 30 years fixing the same problems on himself that his clients bring him.
His answer is the opposite of what most lifters are doing. Less volume, harder sets, shorter warm-ups, wider rep brackets, and a logbook that is loosely held. More carbs, less fat, more meals, no fasting. Morning sun, sleep, a walk after dinner. And a scoreboard most people have never checked: their morning body temperature.
Drew and Jay walk through the CM Punk transformation in detail, the recovery tools that actually move the needle versus the ones that just look good on Instagram, why "eat less, move more" is backwards for the people who are already stuck, how Jay programs cardio for busy people in five to ten minutes, and how to balance looking the part with moving like an athlete.
5 Takeaways
CM Punk was training at 5 reps in reserve with far too much volume. Jay cut the volume and the physique showed up in 6 weeks.Jay ate 200 grams of fat a day for years without knowing it. He cut it to 50 and got the leanest he's ever been at 52.A 95.6° morning temperature means you don't burn fat, build muscle or fight off a cold. The fix starts with orange juice before coffee.Take your temperature before and after a brutal workout. It drops. That's why most of his clients get leaner training less and eating more.His warm-up before the 80-pound dumbbells is three sets totaling 12 reps. Most guys do 40 and wonder why the work sets feel heavy.Chapters
0:00 Intro: Why Half the WWE Roster Got Jacked
2:05 Minimum Effective Dose & Recovery for Banged-Up Athletes
8:16 From 147 Pounds to Coaching Pros: Jay's Background
18:44 The CM Punk Case Study: Volume, Carbs & Sleep
26:09 The Recovery Tools That Actually Move the Needle
30:42 Body Temperature: The Metabolic Scoreboard
37:00 How to Program Cardio & HIIT for Busy People
43:32 Warm-Ups, Rep Brackets & the Logbook Trap
54:55 Balancing Aesthetics & Athleticism in a Program
60:49 What Dogs Taught Jay About Presence
63:59 Building the Perfect Meal Plan
Connect with Jay:
Jay's site & coaching: https://jay.fit
Instagram: https://www.instagram.com/jayferruggia
YouTube: https://www.youtube.com/channel/UCUuDiUu00raDqT_MaNhx_Hw
Renegade Radio podcast (Apple): https://podcasts.apple.com/us/podcast/renegade-radio-with-jay-ferruggia/id853941025
Renegade Radio podcast (Spotify): https://open.spotify.com/show/0Hw50ZFA1gOfC1vQEZDI3u
SLU-PP-332 vs SLU-PP-915: The Science of the New Fat Loss Drugs, Dosing & Blood Work | Pharmacology Coach
2026/09/02
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Max Bertolino runs compounds himself at the doses the studies actually used, then pulls blood. In this episode he and Drew go head to head on SLU-PP-332 vs SLU-PP-915 — why the reported dosing range on 332 spans a thousandfold, what actually happens at the top of that range, and why 915 appears to do the same job at a fraction of the dose with cleaner blood work and none of the hydrazide risk.
From there it opens into the rest of the new metabolic drugs. Max breaks down the estrogen-related receptor mechanism behind the exercise mimetics — why they shift fuel selection toward fat, why they drive GLUT4 and mitochondrial density independent of training, and why the gyno panic around 332 was never pharmacologically possible. He explains ATX-304 (O-304) as a pan-AMPK activator that keeps AMPK switched on by blocking the phosphatase that turns it off, and why twelve weeks at the clinical dose did nothing measurable to his hypertrophy despite everything the AMPK-versus-mTOR crowd predicted. He covers SANA (MVD1) and the futile creatine cycle — a compound whose entire mechanism is making your body waste its own energy accomplishing nothing — along with the phase one tolerability ceiling and the creatine-loading trick one user stacked on top of it.
The back half turns to what the community already runs and gets wrong. Why the SS-31 dose everyone uses was essentially picked out of the air, an order of magnitude below the studies. Why ACE-083 grows muscle volume without a matching increase in force output. Why Masteron's reputation has no pharmacological pedigree behind it. Why Boldenone is a better Primobolan than most people will admit, and why mirabegron and albuterol are the two most overlooked compounds in fat loss.
The through-line: almost every dose and every fear this community operates on was inherited rather than measured. And the single most practical warning in the hour — stack an exercise mimetic with ATX-304 while running a deep deficit on low carbs and fasted cardio, and the compounds are not what puts you on the floor. Your diet is.
TAKEAWAYS
The dosing range on SLU-PP-332 spans a thousandfold. Only one end of it does anything.SLU-PP-915 does the same job at roughly a seventh of the dose — and the blood work comes back cleaner.Stack an exercise mimetic with ATX-304 and it won't be the compounds that put you on the floor. It'll be your diet.The SS-31 dose everyone runs is 2mg. The studies showing kidney benefit start at 40.Mirabegron is a bladder drug for old people. It burns 250 calories a day while you do nothing.
CHAPTERS
00:00 SLU-PP-332 vs SLU-PP-915: The Thousandfold Dosing Range
08:00 Why the Old Bodybuilding Compounds Are a Dead End
15:50 How Exercise Mimetics Work: ERR Activation, GLUT4 & Going Hypo
26:13 ATX-304: Pan-AMPK Activation & the Muscle-Loss Fear
33:31 Stacking ATX With SLU, MOTS-c Redundancy & the SS-31 Dose
41:16 SANA & the Futile Creatine Cycle
48:04 Myostatin Inhibition: ACE-083, Follistatin-344 & Cosmetic Muscle
56:05 Masteron, Anavar & Anadrol: What Still Earns Its Place
1:04:58 Boldenone, Beta-3 Agonism & Albuterol Over Clen
1:12:40 Where to Find Max Bertolino
FIND MAX BERTOLINO — all links verified against his own site, not taken from the transcript
Compound database & archive: https://maxpharma.wiki
YouTube: https://www.youtube.com/@MaximumPharma
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The 7 Levers That Build Every Freak Physique (In the Order You Pull Them) | Alex Hammerstone
2026/08/26
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Alex Hammerstone spent his career holding together two things that usually cancel each other out: a physique built to look like a comic book character, and a body that had to perform in a wrestling ring. In this episode he lays out the full order of operations for building extreme size, and the argument underneath it is that safer use is not lower use. Every input has a range where it still returns something. The job is to push each lever as far as it productively goes and then move to the next one, instead of pushing harder on the one you already finished.
He walks it in sequence: training and calories before any drug, testosterone and a DHT before 19-nors, growth hormone and insulin only once diet and cardio are already consistent, and peptides last because they buy the health headroom that lets the whole thing keep running. Along the way, the blood work cadence he wants, the blood pressure and hematocrit management most people ignore, the supplement protocol he credits for a clean echocardiogram after years of aggressive cycles, and the 2,700mg trenbolone mistake that taught him low doses work better.
What you'll learn
What "safer use" actually means in practice: pushing many levers as far as each one goes, rather than maxing a single pathwayThe full buildout order, from training and calorie structure through anabolics, cardio, GH, insulin and peptidesWhere the real thresholds sit on testosterone and growth hormone, and why insulin follows carbohydrate demand rather than creating itThe blood work cadence, blood pressure and hematocrit management, and the supplement protocol behind a clean echocardiogram after years of aggressive cyclesWhat peptides actually do in an enhanced protocol, and why they are health infrastructure rather than growth drugs
Chapters
0:00 Effort, Method & How He Got Here
7:36 What Safer Use Actually Means
14:11 The Buildout Begins: Training, Calories & First Anabolics
22:39 Estrogen, Neurosteroids & Blood Work Frequency
28:56 Blood Pressure, Hematocrit, Cardiac Scans & Calcium Scores
41:48 Cardio as an Anabolic Tool
45:10 Growth Hormone & Insulin: Thresholds and Demand
54:38 Peptides: The Levers That Keep the Rest Running
1:00:05 Rapid Fire & the Tren Story
Connect with Alex Hammerstone
Instagram: https://www.instagram.com/alexhammerstone/
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How to Get Stronger, Faster & Leaner Without Doing It All at Once | NFL Combine Coach
2026/08/21
AMPLIFY WELLNESS — nationwide bloodwork, no doctor visit required. https://ddtmtd.co/Amplify
JANUS OPTIMIZE — third-party tested research compounds and peptides. Use code DDTSkool at checkout.
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Blaine McConnell played college football, a year of pro arena ball, then went to the CrossFit Games, and spent four years on the US bobsled team. He's 40, he's still setting personal records, and he now coaches athletes through the NFL Combine alongside a roster of people who just want to move like they did at 25.
Which makes him an unusual person to argue that almost everyone is doing too much.
That's the whole hour. Asked where people go wrong, his first answer is that they try to run every protocol, every modality and every biohack at once, and end up failing at most of them. Everything after that is a method for cutting the list down: one to two priorities per block, a high-low week that keeps them from stealing from each other, a talk test instead of a heart-rate monitor, three recovery tools out of everything he has access to, and two metrics.
He also brings the receipts from both ends of the spectrum — a Combine safety who went from 188 pounds and a 4.7 forty to 208 pounds and a 4.4 in ten weeks, and a 55-year-old who needed two years to run a single pain-free sprint. Same system. The only variable was capacity.
If your training week has four goals in it and none of them are moving, this is the one to sit with.
WHAT YOU'LL LEARN
The reason your program has stalled probably isn't the program. It's how many things you're asking your body to get good at simultaneously.A Combine safety put on 20 pounds and cut three tenths off his 40 in ten weeks. A 55-year-old client needed two years to run 60 yards pain-free. Same system, and the difference isn't effort.Sprinting and jumping will make your squat and your bench feel better, and the reason has nothing to do with your legs or your shoulders.He has access to hyperbaric chambers and won't use them. What he does instead takes three tools and he'll tell you exactly when he reaches for each one.He takes 20 grams of creatine on an ordinary day and 40 to 50 when he travels. The reason goes back to a career's worth of concussions.
CHAPTERS
00:00 — Intro
02:14 — The biggest mistake: trying to do everything at once
03:52 — From college football to the US bobsled team
05:38 — Training for athleticism, strength and physique at the same time
08:58 — The warm-up as the entry point to athletic training
13:57 — The adaptation curve: why it feels worse before it feels better
18:44 — The high-low week: 1–2 priorities and how to sequence the rest
24:36 — Two case studies: a Combine safety in 10 weeks, a 55-year-old in two years
27:42 — Matching nutrition to the training stimulus
30:06 — Why athleticism produces the physique people actually want
34:16 — The cardio zones, by talk test instead of heart rate
40:51 — The bike protocol: sprint adaptations without the ground impact
46:15 — Recovery: red light, contrast, and what he skips
51:42 — Supplements, methylene blue, and megadosing creatine
57:20 — Bloodwork, the thyroid he almost missed, and the two metrics he tracks
1:04:07 — Where to find Blaine
FIND BLAINE MCCONNELL
Instagram: https://www.instagram.com/blaine.mcconnell/?hl=en
YouTube: https://www.youtube.com/@Blainemcconnell
This conversation is for informational and educational purposes only and is not medical advice. Talk to a qualified physician before changing anything.
Peptide Science vs. Peptide Hype: Dosing, Naming & the Research Nobody Reads | 25-Year Peptide Pioneer
2026/08/19
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Jean-Francois Tremblay has been working with peptides since the 1990s — back when the only source was China, the only real literature was a forum, and melanotan cost a thousand dollars a day to synthesize. He's a pharmacist with a background in exercise physiology, he came up alongside Charles Poliquin, and his lab was the first to synthesize MOTS-c.
Which means he watched the entire field get built. And he's watching the current boom repeat mistakes that were already settled twenty years ago.
In this episode he takes apart the errors nobody in the space seems to notice: why "TB-500" doesn't reliably tell you which molecule is in the vial, why the GHK-Cu results people are excited about are mostly the copper, why the doses that sound dangerous are the ones the papers actually used, and why the human research everyone says doesn't exist has existed for decades — just not in English.
He also gives you his own protocol, which is a single weekly injection, and the reasoning that makes daily pinning unnecessary for most people. Then he does the thing almost nobody in this space does: when Drew asks him to rank SS-31 against MOTS-c, he says he doesn't know enough to answer.
If you've been running peptides for a few years and you're starting to wonder how much of what you've been told is actually true, this is the hour.
This conversation is for informational and educational purposes only and is not medical advice. Compounds discussed are research chemicals. Nothing here is a recommendation to use them. Talk to a qualified physician before changing anything.
The Fourth Phase of Water: Structured Water, Cellular Hydration & Mitochondrial Energy | Todd Shipman
2026/08/14
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Todd Shipman's education in water came from John Butts — a military nuclear engineer who got into the subject twice over, first through the specialized water used around nuclear weapons, then as a cowboy who noticed that given a trough and a running river, the horses chose the river a thousand times out of a thousand. Butts went on to do his own lab research and ended up consulted by many of the better-known names in the field. Todd worked alongside him for hours at a stretch, sometimes six a day, until Butts died of ketoacidosis. Todd's other education came the hard way, running 100 and 200-mile ultramarathons, where they weighed the runners every ten miles because too many electrolytes and too few produce exactly the same symptoms.
The argument in this episode is that the entire popular conversation about water is stuck on one half of the problem. We talk about what to take out — chlorine, fluoride, microplastics, pharmaceutical residue — and almost never about what the water is once it's clean. Todd's position, inherited from Butts, is close to the opposite of the standard advice: revitalizing matters more than filtering, and the only reason he'd filter at all is taste. Drew pushes him through the practical stack anyway — where reverse osmosis genuinely helps and where it leaves you worse off, why distilled is closer to what nature does, what remineralization actually needs to look like, and why the sodium-to-potassium ratio decides whether the water you drink ends up inside your cells or around them. From there it goes into the fourth phase of water, why hexagonal structure holds more energy, and the claim at the center of the whole thing: that your cells have to convert ordinary water into crystalline water before they can use it, and that conversion costs mitochondrial energy you'd rather spend elsewhere.
5 Key Takeaways
Why a reverse osmosis system can leave you less hydrated than before you bought it, and the two-line fixWhat to check on a filter's published results that most companies were quietly avoiding for yearsWhy too many electrolytes produces the same symptoms as too few, learned over 200-mile racesThe reason your cells can't use a glass of water in the form you drank it, and what that costs youWhat John Butts's horses understood about running water that most of the wellness industry still doesn'tConnect with Todd
Instagram – https://www.instagram.com/thatoddtodd
Natural Action – https://www.naturalaction.com
Natural Action on Instagram – https://www.instagram.com/naturalaction
Disclosure: Todd works with Natural Action, whose devices are discussed throughout, and Drew has an affiliate code with them which lives in the DDT Method School Group.
Enhanced Athlete Risk Management: Dose Economy, Blood Work & Long-Term Health
2026/08/12
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Adam Reich has been in this sport since he was fifteen, competing at Teen Nationals in 2003 alongside Steve Kuclo and Brandon Curry. He competed straight through to 2014, took a decade off, spent five years as a corrections officer working the main intake at Rikers Island, then moved his family to South Florida and went back to coaching full-time — which is what he has actually been doing since 2011. He came back to the stage in 2024 and turned pro. He promotes the IFBB South Florida Pro and the NPC Chisel Classic, had six athletes on the Olympia stage last year, and learned the trade under Dave Palumbo, Chad Nichols, Fakhri Mubarak and George Farah, back when prep meant an hour on the step mill in the morning and another hour at night.
That background is what makes this conversation worth an hour, because Adam now argues almost the opposite of how he was brought up. His whole system is built on using less pharmacological force and controlling the conditions around it instead. Peptides that let him take clenbuterol down to nothing. Starting prep near maintenance rather than in a hole, so there's somewhere to go at eight weeks out. Never more than forty minutes of cardio in a sitting, because the inflammation costs more than the calories buy. Shortening a female's time on rather than cutting a male's dose in half — the poison is in the duration, not the dose. Weekly blood pressure and glucose readings, because a stalled athlete is usually a filtration problem rather than a diet problem. A fifteen-minute walk after a meal instead of another unit of insulin. And a peak week where water and sodium go up rather than down, because water is what carries the carbohydrate into the muscle. He closes with the worst protocol he has ever seen a female handed by another coach, which is the argument for everything above it.
5 Key Takeaways
Why athletes who start prep already underfed have nowhere left to go by six weeks out, and where Adam sets the starting point insteadThe rule that governs how he builds every female cycle, and why halving a male's dose is the most common and most damaging mistake in the sportThe early virilization signs that are still reversible if you catch them, and the ones that aren'tWhat an elevated blood pressure reading tells you about why an athlete has stopped losing weight, and why fixing it moves the scaleWhy he drives water and sodium up in peak week rather than stripping them, and what happens to a carb load when an athlete is dehydratedChapters
0:00 The Peptides That Replaced High-Dose Stimulants
3:44 From Teen Nationals to Rikers Island to Coaching Full-Time
8:18 How Fat Loss Prep Changed: Starting Point, Fatigue and Cardio Structure
14:51 SLU-PP-332, Clenbuterol and Cycling Fat Loss Drugs
23:13 Peptides for Muscle, and Building a Male Cycle
27:31 Female Cycles: Duration Over Dose, Virilization Signs and Multi-Show Strategy
35:31 What Blood Work Keeps Showing, and Managing Hematocrit
39:44 The Cardiovascular Stack, Blood Pressure and Glucose
45:38 Insulin, Carb Timing and the Post-Meal Walk
53:00 Steps, HIIT, Sleep and the Daily Tracker
59:28 Peak Week: Why Water and Sodium Go Up
1:03:42 Where to Find Adam, and the Worst Cycle He's Seen
Connect with Adam
Instagram – https://www.instagram.com/adamreich
Coaching with Team Best Built
How Digestion Controls Nutrient Partitioning, Recovery & Physique Development | Functional Health Coach Austin Stout
2026/08/05
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Austin Stout has spent close to two decades doing something most people in bodybuilding still treat as a side quest: figuring out why two athletes on the same food and the same protocol get completely different results. He started as a wrestler who picked up bodybuilding magazines because there was nothing else to read about lifting, prepped for his first show while still in high school, and went full-time coaching while charging fifty dollars a month and barely covering rent. Then he competed too often, ran himself into hormonal downregulation and digestive problems, and had a doctor tell him plainly that he was killing himself. Working his own way out of that is what pushed him into blood work, GI testing and functional health years before the bodybuilding world had any patience for it — the response to his early posts was mostly "this is b******t, don't complicate it."
What he arrived at is the argument running underneath this entire conversation: the limit is your body's capacity to use what you give it, not the size of what you give it. Almost every standard fix in this sport adds something — more carbs on show morning, more food on a refeed, more cardio, more compounds, more antimicrobials — when the move that actually works is reducing load or rebuilding capacity. Austin walks through what that looks like in practice: why peak week fails on digestion rather than carbs, why a refeed's real benefit is fatigue reduction and not the food, how he doses cardio against an athlete's entire life rather than their training, how to reintroduce food to someone who hasn't eaten a piece of fruit in five years, and why the standard SIBO protocol keeps sending people back around the same loop every few months. Drew brings his own version of it too — the years he assumed he was a poor responder, and what changed when he took his fiber from ten grams a day to seventy.
5 Key Takeaways
Why a flat physiques happen on show morningThe real mechanism behind a refeed and how to enhance itBalancing cardio against an athlete's total stress load rather than against their trainingHow to reintroduce foods after an elimination dietWhy most SIBO and antimicrobial protocols relapse within months
Chapters
0:00 Where Peak Week Goes Wrong: Fiber, Water and Digestion
6:13 Show Day: Why You're Flat and What Actually Fixes It
13:57 From Wrestling to Full-Time Coaching
19:20 Competing Too Often, Blood Work and the Turn to Functional Health
24:15 The Three Camps and the Evolution of Refeeds
29:17 Refeeds Are Fatigue Reduction, Not Just Calories
32:42 Cardio, Diet Leverage and Your Prep Starting Point
40:40 Diet Diversity and Reintroducing Food
45:31 Fiber Types, Dosing and Drew's 10g-to-70g Experiment
52:11 Feeding Good Bacteria: Resistant Starch, Butyrate and SCFAs
59:30 Why SIBO Protocols Keep Failing
1:04:52 Where to Find Austin
Connect with Austin
Instagram – https://www.instagram.com/austinst8
Linktree (coaching, mentorship, education, discount codes) – https://linktr.ee/austinst8
Integrated Muscle & Health – https://intmuscle.com
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