Advertise on podcast: WBM Emergency & Critical Care
Rating
4.9from
Categories
This podcast has
100 episodes
Explicit
No
Date created
2025/04/13
Latest episode
2026/09/30
Average duration
34 min.
Release period
3 days
Description
WBM Emergency & Critical Care is an educational podcast focused on emergency medicine, critical care, and acute care topics. Through physiology-based discussions and evidence-informed reviews, we aim to help healthcare professionals strengthen their understanding of complex clinical concepts. To contact us, email [email protected] WBM provides educational content for healthcare professionals and trainees. Content is intended for educational purposes only and should not be used as a substitute for independent clinical judgment. Full disclaimer: https://whiteboardmedicine.com/disclaimer/
Podcast episodes
Check latest episodes from WBM Emergency & Critical Care podcast
#328 Peak Pressure vs Plateau Pressure Masterclass: Airway Resistance, Lung Compliance, and Pressure
2026/09/30
Peak pressure and plateau pressure are foundational concepts in mechanical ventilation and ventilator troubleshooting. In this masterclass episode, we review airway resistance and lung compliance, then take a deeper dive into peak pressure, plateau pressure, ventilator pressure interpretation, and how these values help identify obstructive physiology, reduced compliance, and ventilator-related problems.
Topics covered include:
• Airway resistance basics
• Lung compliance basics
• Peak pressure basics
• Plateau pressure basics
• Difference between peak pressure and plateau pressure
• How airway resistance affects peak pressure
• How lung compliance affects plateau pressure
• High peak pressure with normal plateau pressure
• High peak pressure with high plateau pressure
• Causes of increased airway resistance
• Causes of decreased lung compliance
• Inspiratory hold maneuver
• Ventilator waveforms and pressure interpretation
• Obstructive physiology and bronchospasm
• ARDS, pulmonary edema, atelectasis, and low compliance
• Practical ventilator troubleshooting
• Bedside approach to peak and plateau pressure changes
Watch the full video on YouTube: https://www.youtube.com/watch?v=RLIJKFpD1H4
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Patreon members receive access to:
• Downloadable Study Guides
• Clinical One-Pagers
• Practice Questions
• Mini-Courses
• Comprehensive Clinical Reviews
• Ad-Free Videos
• Early Access Content
🌐 WhiteBoard Medicine Website
Explore our growing library of critical care and emergency medicine content:
https://www.whiteboardmedicine.com
⚠️ Educational Disclaimer:
This content is intended for educational purposes only and should not be used as a substitute for clinical judgment, institutional protocols, specialist consultation, or individualized patient care.
Full disclaimer: https://whiteboardmedicine.com/disclaimer
#327 Airway Resistance & Lung Compliance Explained: Peak Pressure, Plateau Pressure, Ventilator Basics
2026/09/28
Airway resistance and lung compliance are foundational concepts for understanding mechanical ventilation, peak pressure, plateau pressure, and ventilator troubleshooting. In this episode, we review what airway resistance and lung compliance mean, how they affect ventilator pressures, and how to interpret changes in peak and plateau pressure at the bedside.
Topics covered include:
• What airway resistance means
• What lung compliance means
• Peak pressure basics
• Plateau pressure basics
• Difference between peak pressure and plateau pressure
• How airway resistance affects peak pressure
• How lung compliance affects plateau pressure
• High airway resistance patterns
• Low lung compliance patterns
• Common causes of increased airway resistance
• Common causes of decreased lung compliance
• Ventilator waveform basics
• Practical interpretation of ventilator pressures
• Introductory ventilator troubleshooting
Watch the full video on YouTube: https://www.youtube.com/watch?v=rugnCUpH6S8
📚 Want More Emergency & Critical Care Medicine Education?
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Patreon members receive access to:
• Downloadable Study Guides
• Clinical One-Pagers
• Practice Questions
• Mini-Courses
• Comprehensive Clinical Reviews
• Ad-Free Videos
• Early Access Content
🌐 WhiteBoard Medicine Website
Explore our growing library of critical care and emergency medicine content:
https://www.whiteboardmedicine.com
⚠️ Educational Disclaimer:
This content is intended for educational purposes only and should not be used as a substitute for clinical judgment, institutional protocols, specialist consultation, or individualized patient care.
Full disclaimer: https://whiteboardmedicine.com/disclaimer
#326 PaO2 vs Oxygen Saturation vs Oxygen Content Explained: Key Differences in Oxygenation
2026/09/26
PaO2, oxygen saturation, and oxygen content are related but very different ways of understanding oxygenation and oxygen delivery. In this episode, we compare PaO2, SpO2/SaO2, and arterial oxygen content, focusing on what each value means, how they are measured, how they relate to hemoglobin, and why normal oxygen saturation does not always mean normal oxygen delivery.
Topics covered include:
• What PaO2 means
• What oxygen saturation means
• SpO2 versus SaO2
• What oxygen content means
• The oxygen-hemoglobin dissociation curve
• Relationship between PaO2 and oxygen saturation
• Hemoglobin-bound oxygen versus dissolved oxygen
• Arterial oxygen content and the CaO2 equation
• Why hemoglobin concentration matters
• Oxygen delivery and the DO2 equation
• Anemia and oxygen content
• Hypoxemia and oxygen saturation
• Shock and impaired oxygen delivery
• Practical clinical interpretation of oxygenation values
Watch the full video on YouTube: https://www.youtube.com/watch?v=eMNinvf9hk8
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• Downloadable Study Guides
• Clinical One-Pagers
• Practice Questions
• Mini-Courses
• Comprehensive Clinical Reviews
• Ad-Free Videos
• Early Access Content
🌐 WhiteBoard Medicine Website
Explore our growing library of critical care and emergency medicine content:
https://www.whiteboardmedicine.com
⚠️ Educational Disclaimer:
This content is intended for educational purposes only and should not be used as a substitute for clinical judgment, institutional protocols, specialist consultation, or individualized patient care.
Full disclaimer: https://whiteboardmedicine.com/disclaimer
#325 Decompensating Aortic Regurgitation Explained: Recognition, Hemodynamics, and Emergency Management
2026/09/24
Decompensating aortic regurgitation is a high-risk clinical scenario where severe aortic valve insufficiency can lead to pulmonary edema, hypotension, cardiogenic shock, and rapid hemodynamic collapse. In this episode, we review the physiology of aortic regurgitation, how acute and chronic aortic regurgitation can decompensate, key bedside recognition features, and the principles of emergency and critical care management.
Topics covered include:
• What aortic regurgitation is
• Acute versus chronic aortic regurgitation
• Aortic valve insufficiency and regurgitant flow
• Left ventricular volume overload
• Diastolic runoff and low diastolic pressure
• Wide pulse pressure in chronic aortic regurgitation
• Pulmonary edema in acute aortic regurgitation
• Hypotension and cardiogenic shock
• Why bradycardia can worsen aortic regurgitation
• Afterload and forward flow considerations
• Bedside recognition and diagnostic clues
• Murmur findings and pulse pressure patterns
• ECG, chest X-ray, point-of-care ultrasound, and echocardiography
• Vasodilator, vasopressor, and inotrope considerations
• Avoiding common management pitfalls
• Valve intervention and definitive management
Watch the full video on YouTube: https://www.youtube.com/watch?v=4yDoxqxgk1c
📚 Want More Emergency & Critical Care Medicine Education?
Join the WhiteBoard Medicine Patreon community:
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Patreon members receive access to:
• Downloadable Study Guides
• Clinical One-Pagers
• Practice Questions
• Mini-Courses
• Comprehensive Clinical Reviews
• Ad-Free Videos
• Early Access Content
🌐 WhiteBoard Medicine Website
Explore our growing library of critical care and emergency medicine content:
https://www.whiteboardmedicine.com
⚠️ Educational Disclaimer:
This content is intended for educational purposes only and should not be used as a substitute for clinical judgment, institutional protocols, specialist consultation, or individualized patient care.
Full disclaimer: https://whiteboardmedicine.com/disclaimer
#324 Decompensating Aortic Stenosis Explained: Recognition, Hemodynamics, and Emergency Management
2026/09/22
Decompensating aortic stenosis is a high-risk clinical scenario where fixed left ventricular outflow obstruction can lead to hypotension, pulmonary edema, cardiogenic shock, arrhythmias, and rapid hemodynamic collapse. In this episode, we review the physiology of severe aortic stenosis, how decompensation develops, key bedside recognition features, and the principles of emergency and critical care management.
Topics covered include:
• What aortic stenosis is
• Severe aortic stenosis physiology
• Fixed left ventricular outflow obstruction
• Pressure overload and left ventricular hypertrophy
• Preload dependence and diastolic filling
• Coronary perfusion considerations
• Why tachycardia and hypotension are dangerous
• Pulmonary edema in aortic stenosis
• Syncope, angina, dyspnea, and heart failure symptoms
• Decompensated aortic stenosis and cardiogenic shock
• Bedside recognition and diagnostic clues
• ECG, chest X-ray, point-of-care ultrasound, and echocardiography
• Vasopressor and fluid considerations
• Avoiding common management pitfalls
• Valve intervention and definitive management
Watch the full video on YouTube: https://www.youtube.com/watch?v=Idk53aRgELM
📚 Want More Emergency & Critical Care Medicine Education?
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Patreon members receive access to:
• Downloadable Study Guides
• Clinical One-Pagers
• Practice Questions
• Mini-Courses
• Comprehensive Clinical Reviews
• Ad-Free Videos
• Early Access Content
🌐 WhiteBoard Medicine Website
Explore our growing library of critical care and emergency medicine content:
https://www.whiteboardmedicine.com
⚠️ Educational Disclaimer:
This content is intended for educational purposes only and should not be used as a substitute for clinical judgment, institutional protocols, specialist consultation, or individualized patient care.
Full disclaimer: https://whiteboardmedicine.com/disclaimer
#323 Mechanical Ventilation Masterclass: Optimizing PEEP with Driving Pressure and Stress Index
2026/09/20
PEEP optimization is a key part of lung-protective mechanical ventilation, especially when managing hypoxemia, atelectasis, ARDS, overdistension, tidal recruitment, and ventilator-induced lung injury. In this episode, we review how driving pressure and stress index can help guide PEEP decisions and support a more physiologic approach to ventilator management.
Topics covered include:
• What PEEP is
• Why PEEP optimization matters
• Alveolar recruitment and derecruitment
• Overdistension and lung stress
• Driving pressure and respiratory system compliance
• Plateau pressure, PEEP, and tidal volume relationships
• Stress index and pressure-time waveform interpretation
• Stress index less than 1
• Stress index equal to 1
• Stress index greater than 1
• Using driving pressure to guide PEEP
• Using stress index to guide PEEP
• Balancing recruitment and overdistension
• Lung-protective ventilation in ARDS
• Practical bedside approach to PEEP optimization
• Limitations and clinical context
Watch the full video on YouTube: https://www.youtube.com/watch?v=7TYioPC4_lo
📚 Want More Emergency & Critical Care Medicine Education?
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• Clinical One-Pagers
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• Mini-Courses
• Comprehensive Clinical Reviews
• Ad-Free Videos
• Early Access Content
🌐 WhiteBoard Medicine Website
Explore our growing library of critical care and emergency medicine content:
https://www.whiteboardmedicine.com
⚠️ Educational Disclaimer:
This content is intended for educational purposes only and should not be used as a substitute for clinical judgment, institutional protocols, specialist consultation, or individualized patient care.
Full disclaimer: https://whiteboardmedicine.com/disclaimer
#322 Refractory Shock Masterclass: Nitric Oxide Scavengers, Methylene Blue, and Hydroxocobalamin
2026/09/18
Methylene blue and hydroxocobalamin are rescue therapies sometimes considered for vasoplegic shock and refractory vasodilation. In this episode, we compare methylene blue with hydroxocobalamin, focusing on mechanisms of action, nitric oxide-mediated vasodilation, hemodynamic effects, dosing considerations, adverse effects, and practical clinical use.
Topics covered include:
• What vasoplegic shock is
• Refractory vasodilation and shock physiology
• Nitric oxide-mediated vasodilation
• Methylene blue mechanism of action
• Hydroxocobalamin mechanism of action
• Hemodynamic effects of methylene blue
• Hemodynamic effects of hydroxocobalamin
• Clinical scenarios where these agents may be considered
• Dosing and administration considerations
• Adverse effects and monitoring
• Interference with labs, pulse oximetry, and dialysis machines
• Methylene blue versus hydroxocobalamin comparison
• Practical bedside considerations in vasoplegic shock
Watch the full video on YouTube: https://www.youtube.com/watch?v=D77f6YsQhbs
📚 Want More Emergency & Critical Care Medicine Education?
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Patreon members receive access to:
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• Clinical One-Pagers
• Practice Questions
• Mini-Courses
• Comprehensive Clinical Reviews
• Ad-Free Videos
• Early Access Content
🌐 WhiteBoard Medicine Website
Explore our growing library of critical care and emergency medicine content:
https://www.whiteboardmedicine.com
⚠️ Educational Disclaimer:
This content is intended for educational purposes only and should not be used as a substitute for clinical judgment, institutional protocols, specialist consultation, or individualized patient care.
Full disclaimer: https://whiteboardmedicine.com/disclaimer
#321 Driving Pressure vs Stress Index Compared: Mechanical Ventilation, Alveolar Distention, and Waveform
2026/09/16
Driving pressure and stress index are two important concepts used to think about lung stress, lung-protective ventilation, overdistension, tidal recruitment, and ventilator-induced lung injury. In this episode, we compare driving pressure with stress index, focusing on what each measurement means, how they are interpreted, how they relate to compliance and ventilator waveforms, and how they can inform mechanical ventilation strategy.
Topics covered include:
• What driving pressure is
• What stress index is
• Plateau pressure, PEEP, and driving pressure
• Pressure-time waveform interpretation
• Lung stress and strain during mechanical ventilation
• Respiratory system compliance
• Overdistension
• Tidal recruitment and derecruitment
• Stress index less than 1
• Stress index equal to 1
• Stress index greater than 1
• Driving pressure and lung-protective ventilation
• Stress index and ventilator waveform analysis
• Comparing driving pressure and stress index
• Practical bedside applications and limitations
Watch the full video on YouTube: https://www.youtube.com/watch?v=fULtSMAxMJ8
📚 Want More Emergency & Critical Care Medicine Education?
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Patreon members receive access to:
• Downloadable Study Guides
• Clinical One-Pagers
• Practice Questions
• Mini-Courses
• Comprehensive Clinical Reviews
• Ad-Free Videos
• Early Access Content
🌐 WhiteBoard Medicine Website
Explore our growing library of critical care and emergency medicine content:
https://www.whiteboardmedicine.com
⚠️ Educational Disclaimer:
This content is intended for educational purposes only and should not be used as a substitute for clinical judgment, institutional protocols, specialist consultation, or individualized patient care.
Full disclaimer: https://whiteboardmedicine.com/disclaimer
#320 Methylene Blue vs Hydroxocobalamin Compared: Vasoplegic Shock, Mechanisms, Adverse Effects, and Use
2026/09/14
Methylene blue and hydroxocobalamin are rescue therapies sometimes considered for vasoplegic shock and refractory vasodilation. In this episode, we compare methylene blue with hydroxocobalamin, focusing on mechanisms of action, nitric oxide-mediated vasodilation, hemodynamic effects, dosing considerations, adverse effects, and practical clinical use.
Topics covered include:
• What vasoplegic shock is
• Refractory vasodilation and shock physiology
• Nitric oxide-mediated vasodilation
• Methylene blue mechanism of action
• Hydroxocobalamin mechanism of action
• Hemodynamic effects of methylene blue
• Hemodynamic effects of hydroxocobalamin
• Clinical scenarios where these agents may be considered
• Dosing and administration considerations
• Adverse effects and monitoring
• Interference with labs, pulse oximetry, and dialysis machines
• Methylene blue versus hydroxocobalamin comparison
• Practical bedside considerations in vasoplegic shock
Watch the full video on YouTube: https://www.youtube.com/watch?v=LfBMevNxEfg
📚 Want More Emergency & Critical Care Medicine Education?
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Patreon members receive access to:
• Downloadable Study Guides
• Clinical One-Pagers
• Practice Questions
• Mini-Courses
• Comprehensive Clinical Reviews
• Ad-Free Videos
• Early Access Content
🌐 WhiteBoard Medicine Website
Explore our growing library of critical care and emergency medicine content:
https://www.whiteboardmedicine.com
⚠️ Educational Disclaimer:
This content is intended for educational purposes only and should not be used as a substitute for clinical judgment, institutional protocols, specialist consultation, or individualized patient care.
Full disclaimer: https://whiteboardmedicine.com/disclaimer
#319 Stress Index Explained: Mechanical Ventilation, Alveolar Distention, and Pressure Time Waveform
2026/09/12
The stress index is a ventilator waveform concept used to assess lung stress, overdistension, and tidal recruitment during mechanical ventilation. In this episode, we review what the stress index is, how it is interpreted on ventilator waveforms, how it relates to lung-protective ventilation, and how clinicians use it to think about PEEP, tidal volume, compliance, and ventilator-induced lung injury.
Topics covered include:
• What the stress index is
• Pressure-time waveform interpretation
• Lung stress and strain during mechanical ventilation
• Overdistension and excessive tidal volume
• Tidal recruitment and derecruitment
• Relationship between stress index and compliance
• Stress index less than 1
• Stress index equal to 1
• Stress index greater than 1
• PEEP adjustment and lung recruitment
• Tidal volume adjustment and lung-protective ventilation
• Ventilator-induced lung injury
• Practical bedside applications of the stress index
• Limitations of stress index interpretation
Watch the full video on YouTube: https://www.youtube.com/watch?v=ybrdFe8rlOo
📚 Want More Emergency & Critical Care Medicine Education?
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Patreon members receive access to:
• Downloadable Study Guides
• Clinical One-Pagers
• Practice Questions
• Mini-Courses
• Comprehensive Clinical Reviews
• Ad-Free Videos
• Early Access Content
🌐 WhiteBoard Medicine Website
Explore our growing library of critical care and emergency medicine content:
https://www.whiteboardmedicine.com
⚠️ Educational Disclaimer:
This content is intended for educational purposes only and should not be used as a substitute for clinical judgment, institutional protocols, specialist consultation, or individualized patient care.
Full disclaimer: https://whiteboardmedicine.com/disclaimer
#318 Norepinephrine Masterclass: Foundations, Clinical Scenarios, Dosing, Bedside Applications
2026/09/10
Norepinephrine is one of the most important vasopressors in emergency medicine and critical care. In this masterclass episode, we review the foundations of norepinephrine, including mechanism of action, receptor effects, hemodynamics, dosing, adverse effects, and monitoring, then take a deeper dive into clinical scenarios and bedside applications where norepinephrine is commonly used.
Topics covered include:
• What norepinephrine is
• Norepinephrine mechanism of action
• Alpha-1, beta-1, and beta-2 receptor effects
• Hemodynamic effects on vascular tone and cardiac output
• Norepinephrine dosing and titration
• Central versus peripheral administration
• Norepinephrine adverse effects and monitoring
• Norepinephrine in septic shock
• Norepinephrine in distributive shock
• Norepinephrine in cardiogenic shock
• Norepinephrine in hemorrhagic shock
• Norepinephrine in post-intubation hypotension
• Norepinephrine and bradycardia
• Norepinephrine versus epinephrine
• Norepinephrine versus phenylephrine
• Extravasation and safety considerations
• Practical bedside norepinephrine scenarios
Watch the full video on YouTube: https://www.youtube.com/watch?v=vFjL5sp3MSk
📚 Want More Emergency & Critical Care Medicine Education?
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Patreon members receive access to:
• Downloadable Study Guides
• Clinical One-Pagers
• Practice Questions
• Mini-Courses
• Comprehensive Clinical Reviews
• Ad-Free Videos
• Early Access Content
🌐 WhiteBoard Medicine Website
Explore our growing library of critical care and emergency medicine content:
https://www.whiteboardmedicine.com
⚠️ Educational Disclaimer:
This content is intended for educational purposes only and should not be used as a substitute for clinical judgment, institutional protocols, specialist consultation, or individualized patient care.
Full disclaimer: https://whiteboardmedicine.com/disclaimer
#317 Dobutamine vs Milrinone Masterclass: Mechanisms, Hemodynamics, Dosing, And Clinical Use
2026/09/08
Dobutamine and milrinone are two important inotropes used in heart failure, cardiogenic shock, low cardiac output states, and critical care. In this masterclass episode, we compare dobutamine and milrinone with a focus on mechanisms of action, receptor effects, hemodynamics, dosing considerations, adverse effects, monitoring, and practical bedside use.
Topics covered include:
• What inotropes are
• Cardiac output, contractility, and hemodynamics
• Dobutamine mechanism of action
• Dobutamine receptor effects
• Dobutamine hemodynamic profile
• Dobutamine dosing considerations
• Dobutamine adverse effects and monitoring
• Milrinone mechanism of action
• Phosphodiesterase-3 inhibition
• Milrinone hemodynamic profile
• Milrinone dosing considerations
• Milrinone adverse effects and monitoring
• Dobutamine versus milrinone comparison
• Cardiogenic shock and acute decompensated heart failure
• Pulmonary hypertension and right ventricular failure considerations
• Practical ICU and emergency medicine applications
Watch the full video on YouTube: https://www.youtube.com/watch?v=U65DnH9VSoE
📚 Want More Emergency & Critical Care Medicine Education?
Join the WhiteBoard Medicine Patreon community:
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Patreon members receive access to:
• Downloadable Study Guides
• Clinical One-Pagers
• Practice Questions
• Mini-Courses
• Comprehensive Clinical Reviews
• Ad-Free Videos
• Early Access Content
🌐 WhiteBoard Medicine Website
Explore our growing library of critical care and emergency medicine content:
https://www.whiteboardmedicine.com
⚠️ Educational Disclaimer:
This content is intended for educational purposes only and should not be used as a substitute for clinical judgment, institutional protocols, specialist consultation, or individualized patient care.
Full disclaimer: https://whiteboardmedicine.com/disclaimer
#316 Norepinephrine Explained: Principles, Clinical Applications, and Unique Scenarios
2026/09/06
Norepinephrine is one of the most important vasopressors in emergency medicine and critical care. In this episode, we review norepinephrine with a focus on core principles, clinical applications, dosing, hemodynamic effects, receptor physiology, adverse effects, and unique bedside scenarios where norepinephrine is commonly considered.
Topics covered include:
• What norepinephrine is
• Norepinephrine mechanism of action
• Alpha-1, beta-1, and beta-2 receptor effects
• Hemodynamic effects on blood pressure and cardiac output
• Norepinephrine dosing considerations
• Norepinephrine in septic shock
• Norepinephrine in distributive shock
• Norepinephrine in cardiogenic shock
• Norepinephrine in hemorrhagic shock
• Norepinephrine in post-intubation hypotension
• Peripheral norepinephrine considerations
• Norepinephrine extravasation
• Norepinephrine versus epinephrine
• Norepinephrine versus phenylephrine
• Adverse effects and monitoring
• Practical bedside applications and clinical scenarios
Watch the full video on YouTube: https://www.youtube.com/watch?v=w13P5CZWliY
📚 Want More Emergency & Critical Care Medicine Education?
Join the WhiteBoard Medicine Patreon community:
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Patreon members receive access to:
• Downloadable Study Guides
• Clinical One-Pagers
• Practice Questions
• Mini-Courses
• Comprehensive Clinical Reviews
• Ad-Free Videos
• Early Access Content
🌐 WhiteBoard Medicine Website
Explore our growing library of critical care and emergency medicine content:
https://www.whiteboardmedicine.com
⚠️ Educational Disclaimer:
This content is intended for educational purposes only and should not be used as a substitute for clinical judgment, institutional protocols, specialist consultation, or individualized patient care.
Full disclaimer: https://whiteboardmedicine.com/disclaimer
#315 Dobutamine vs Milrinone Explained: Key Differences, Hemodynamics, and Clinical Use
2026/09/04
Dobutamine and milrinone are two commonly used inotropes with important differences in mechanism, hemodynamics, dosing, adverse effects, and clinical use. In this episode, we review the key differences between dobutamine and milrinone and how to think through inotrope selection at the bedside.
Topics covered include:
• Dobutamine mechanism of action
• Milrinone mechanism of action
• Beta-1 agonism versus PDE-3 inhibition
• Hemodynamic effects of dobutamine
• Hemodynamic effects of milrinone
• Effects on heart rate, contractility, and vascular tone
• Pulmonary vascular resistance considerations
• Renal function considerations
• Common indications
• Adverse effects and monitoring
• Practical dobutamine versus milrinone comparison
Watch the full video on YouTube: https://www.youtube.com/watch?v=NDHbQxwMYIA
📚 Want More Emergency & Critical Care Medicine Education?
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Patreon members receive access to:
• Downloadable Study Guides
• Clinical One-Pagers
• Practice Questions
• Mini-Courses
• Comprehensive Clinical Reviews
• Ad-Free Videos
• Early Access Content
🌐 WhiteBoard Medicine Website
Explore our growing library of critical care and emergency medicine content:
https://www.whiteboardmedicine.com
⚠️ Educational Disclaimer:
This content is intended for educational purposes only and should not be used as a substitute for clinical judgment, institutional protocols, specialist consultation, or individualized patient care.
Full disclaimer: https://whiteboardmedicine.com/disclaimer
#314 Masterclass Oxygen Hemoglobin Dissociation Curve: Basics, Shifts, Bohr, Oxygen Content, Applications
2026/08/30
The oxygen-hemoglobin dissociation curve is a foundational concept for understanding oxygen binding, oxygen unloading, hemoglobin saturation, P50, left and right shifts, oxygen content, oxygen delivery, and clinical oxygenation. In this masterclass episode, we bring together the core physiology and advanced applications of the oxygen-hemoglobin dissociation curve, including the Bohr effect, 2,3-BPG, anemia, sepsis, shock, and tissue oxygen delivery.
Topics covered include:
• What the oxygen-hemoglobin dissociation curve is
• Hemoglobin saturation and PaO2
• Oxygen binding and oxygen unloading
• Sigmoidal shape of the curve
• Hemoglobin oxygen affinity
• P50 and what it means
• Left shift of the oxygen-hemoglobin curve
• Right shift of the oxygen-hemoglobin curve
• Temperature, pH, CO2, and 2,3-BPG
• Bohr effect and oxygen unloading
• Oxygen content and the CaO2 equation
• Oxygen delivery and the DO2 equation
• Relationship between hemoglobin, saturation, PaO2, and cardiac output
• Oxygen delivery in anemia
• Oxygen delivery in sepsis and shock
• Tissue oxygen extraction and oxygen consumption
• Practical clinical applications in critical care
Watch the full video on YouTube: https://www.youtube.com/watch?v=JoLafLHdQss
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Join a growing emergency medicine, critical care, and resuscitation education community built around high-yield clinical learning.
Patreon members get access to:
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• Mini-Courses
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🌐 WhiteBoard Medicine Website
Explore our growing library of critical care and emergency medicine content:
https://www.whiteboardmedicine.com
⚠️ Educational Disclaimer:
This content is intended for educational purposes only and should not be used as a substitute for clinical judgment, institutional protocols, specialist consultation, or individualized patient care.
Full disclaimer: https://whiteboardmedicine.com/disclaimer