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In this episode of The Feldman Protocol, what does it actually cost — personally and professionally — to practice medicine from the inside? Lily Johnston (MD), vascular surgeon and author of *Disconnected*, joins Dave for a deep-dive through her book, covering the evolution of doctor-patient relationships, the Women's Health Initiative and how Lily Johnston argues its findings were misapplied, the intelligence community's approach to uncertainty versus medicine's culture of false confidence, the three myths of informed consent, and physician mental health and suicide. Lily's book is now available: https://www.amazon.com/Disconnected-Surgeons-Search-Healing-Broken/dp/B0H86K1T7R 📎 Mentioned in this episode: • 1:41 – Dr. Lily Johnston's book: Disconnect: `https://amplifypublishinggroup.com/product/nonfiction/industries/healthcare-and-medical/disconnected/` • 1:00:00 – DOPS — Danish Osteoporosis Prevention Study (oral estradiol, all-cause mortality): `https://doi.org/10.1136/bmj.e6409` • 2:05:41 – 2023 AAS Presidential Address — "Removing the Mask" by Dr. Carrie Cunningham: `https://www.youtube.com/watch?v=JaNBH4UPHv4` • 2:09:19 – Dr. Lorna Breen — physician suicide awareness / Dr. Lorna Breen Heroes' Foundation: `https://drlornabreen.org` 🔥 This episode is sponsored by us -- Own Your Labs 👉 `https://ownyourlabs.com/sp/60` Private blood testing services 🩸Over 300 blood tests 💰Extremely affordable ❤️ We love our customers (Yes, we are literally funding the entire podcast from our own company -- so if you want to show your support, keep getting your private blood testing through our service. Thank you! 🙏) 🔗 CONNECT WITH LILY JOHNSTON: YouTube: `https://www.youtube.com/@lilyjohnstonmd` X/Twitter: `https://@lilyej` Instagram: `https://@lilyjohnstonmd` Website: `https://www.disconnectedthebook.com` 🔗 CONNECT WITH DAVE FELDMAN: Main Channel: `https://youtube.com/@realDaveFeldman` X/Twitter: `https://x.com/realDaveFeldman` Instagram: `https://instagram.com/realDaveFeldman` Website: `https://thefeldmanprotocol.com` ⏱ Chapters 0:00 – Cold open & book intro 4:07 – Lily's path to surgery 7:34 – How medicine changed between generations 16:20 – The gap year dream vs. pre-med culture 24:17 – Intelligence work and cognitive bias 34:02 – Half of what we teach may be wrong 37:38 – Eminence vs. evidence-based medicine 48:08 – Women's Health Initiative discussion 58:06 – Lily's perspective on hormone therapy 1:00:43 – A story from a medical student rotation 1:17:13 – Red Team thinking vs. medical hierarchy 1:27:38 – The three myths of informed consent 1:36:39 – Risk, population data & spidey sense 1:50:29 – Adam's case and moral injury 1:57:46 – Johnston's Rules of Surgery 2:01:56 – The AAS presidential address 2:09:17 – Physician mental health and systemic barriers 2:13:33 – Disability insurance and seeking therapy #FeldmanProtocol #DaveFeldman #LilyJohnston #MedicalCulture #InformedConsent #PhysicianWellbeing #HormoneTherapy #WomensHealthInitiative #CognitiveBias #VascularSurgery #MoralInjury #EvidenceBasedMedicine #MedicalEducation #PatientAdvocacy #Disconnected #DoctorPatientRelationship #PhysicianMentalHealth #CardiometabolicHealth

In this episode of The Feldman Protocol, what does nearly three decades of low-carb living actually look like when life keeps throwing curveballs? Maria Emmerich (nutritionist and author of 24 cookbooks) joins Dave to share how a PCOS diagnosis at 16 set her on an unconventional path long before keto entered the mainstream. They discuss lipotoxicity, the protein-sparing modified fast approach, LDL in the context of high-fat diets, hormones and HRT, and the role of coaching in long-term dietary adherence. 📎 Mentioned in this episode: • 27:30 – Maria Emmerich's book series: The Art of Eating Healthy: `https://keto-adapted.com/product-category/ebooks/` • 28:22 – Maria Emmerich's book: Keto Adapted: `https://www.amazon.com/Keto-Adapted-Maria-Emmerich-ebook/dp/B00GTU9AJC` • 1:22:44 – Maria Emmerich's website: ketomaria.com: `https://ketomaria.com/` • 1:48:58 – Maria Emmerich's book: The Art of Metabolic Health: `https://www.amazon.com/Art-Metabolic-Health-METABOLIC-RESILIENCE/dp/B0GWWK9HLC` • 2:18:42 – Maria Emmerich's YouTube channel: `https://www.youtube.com/channel/UCyZia0TtezGqjGcXwXJhDoQ` 🔥 This episode is sponsored by us -- Own Your Labs 👉 `https://ownyourlabs.com/sp/58` Private blood testing services 🩸Over 300 blood tests 💰Extremely affordable ❤️ We love our customers (Yes, we are literally funding the entire podcast from our own company -- so if you want to show your support, keep getting your private blood testing through our service. Thank you! 🙏) 🔗 CONNECT WITH DAVE FELDMAN: Main Channel: `https://youtube.com/@realDaveFeldman` X/Twitter: `https://x.com/realDaveFeldman` Instagram: `https://instagram.com/realDaveFeldman` Website: `https://thefeldmanprotocol.com` ⏱ Chapters 0:00 – Cold open & introduction 3:59 – PCOS diagnosis at 16 and diet origins 13:07 – Starting a nutrition business from scratch 18:39 – Adoption journey and financial hardship 33:09 – Craig's Lyme disease diagnosis 43:15 – How Dave and Maria first met 51:56 – Protein-sparing modified fast explained 1:00:01 – Family carnivore experiment and homeschooling 1:05:12 – LDL, saturated fat, and dietary adjustments 1:11:11 – Lipotoxicity and personal fat threshold 1:27:21 – Maria's ICU hospitalizations and electrolytes 1:32:07 – Gluconeogenesis and carb reintroduction 1:43:48 – GLP medications and the community's future 1:55:21 – Hormones, HRT, and testosterone in women 2:03:12 – Physical and emotional wellbeing; whale surfing 2:07:57 – Bow hunting story and patience 2:10:39 – Cookbooks in eldercare and closing reflections 2:17:16 – AI, creativity, and wrapping up #FeldmanProtocol #DaveFeldman #MariaEmmerich #Keto #LowCarb #MetabolicHealth #ProteinSparingModifiedFast #Lipotoxicity #PCOS #LDL #HRT #Carnivore #CookbookAuthor #NutritionCoaching #IntermittentFasting #GLP1 #BloodWork #Hormones #WeightLoss

In this episode of The Feldman Protocol, can individual biology shape whether a given diet or protocol actually works — or does one approach fit everyone? Craig Emmerich (co-author and nutrition researcher alongside Maria Emmerich) makes the case for bioindividuality in metabolic health, discussing his decade-long journey with chronic Lyme disease and ankylosing spondylitis, the protein-sparing modified fast as a weight-loss tool, a fat-cell–centric view of insulin resistance, oxidative priority of fuel sources, and whether AI may reshape personalized medicine. 📎 Mentioned in this episode: • 23:34 – Craig & Maria Emmerich — The Art of Metabolic Health (book): `https://www.amazon.com/Art-Metabolic-Health-METABOLIC-RESILIENCE/dp/B0GWWK9HLC` • 1:46:03 – Craig & Maria Emmerich — Carnivore Cookbook (book): `https://www.victorybelt.com/the-carnivore-cookbook` • 1:48:59 – Podcast episode: Craig Emmerich on Judy Cho's podcast: `https://podcasts.apple.com/us/podcast/nutrition-with-judy-carnivore-diet/id1529951307` • 2:32:25 – Maria Emmerich — ketomaria.com (books, blog, social media hub): `https://ketomaria.com/` 🔥 This episode is sponsored by us -- Own Your Labs 👉 `https://ownyourlabs.com/sp/` Private blood testing services 🩸Over 300 blood tests 💰Extremely affordable ❤️ We love our customers (Yes, we are literally funding the entire podcast from our own company -- so if you want to show your support, keep getting your private blood testing through our service. Thank you! 🙏) 🔗 CONNECT WITH DAVE FELDMAN: Main Channel: `https://youtube.com/@realDaveFeldman` X/Twitter: `https://x.com/realDaveFeldman` Instagram: `https://instagram.com/realDaveFeldman` Website: `https://thefeldmanprotocol.com` ⏱ Chapters 0:00 – Introduction & cold open 1:18 – Craig's background and origin story 5:00 – Engineering path and college years 8:41 – Honeywell: defense tech & Land Warrior 14:15 – Traveling the world in chip testing 21:26 – Publishing the first low-carb cookbook 32:18 – Meeting Dave & low-carb conference circuit 38:24 – Chronic pain and the road to diagnosis 45:13 – Ankylosing spondylitis and Lyme co-infections 54:40 – Diet as symptom management vs. root cause 1:01:43 – Hip replacement and recovery 1:07:08 – Protein-sparing modified fast explained 1:22:18 – Fat cells, insulin resistance & personal fat threshold 1:35:29 – Lipodystrophy, leptin & ectopic fat 1:47:32 – Carnivore as elimination protocol 1:59:01 – Insulin, weight loss & the carbohydrate debate 2:09:52 – Oxidative priority of fuels 2:17:00 – Listener Q&A and closing thoughts #FeldmanProtocol #DaveFeldman #CraigEmmerich #MariaEmmerich #LowCarb #Ketogenic #ProteinSparing #InsulinResistance #LymeDisease #AnkylosingSpondylitis #MetabolicHealth #FatCells #PersonalFatThreshold #OxidativePriority #Carnivore #ProteinPrioritized #Bioindividuality #ChronicPain #NutritionScience

In this episode of The Feldman Protocol, how should researchers and clinicians weigh insulin resistance against lipid markers when assessing cardiovascular risk? Dave Feldman sits down with Sameer Dossani (PhD, anthropology; health coach specializing in autoimmune and gut conditions) to explore human evolutionary dietary history, the origins of metabolic disease across ancient cultures, the lean mass hypersponder phenotype and ketone production, challenges in science communication, and the role of AI in personalized health. 📎 Mentioned in this episode: • 1:23:33 – Bradford Hill 1965 — 'Environment and Disease' (criteria paper): `https://pmc.ncbi.nlm.nih.gov/articles/PMC1898525/` • 1:33:20 – Ramsden 2015 re-analysis — Minnesota Coronary Experiment & Sydney Diet Heart Trial: `https://doi.org/10.1136/bmj.i1246` • 2:23:35 – Zero-fiber vs high-fiber constipation RCT (2012) — discussed by Nick Norwitz: `https://www.wjgnet.com/1007-9327/full/v18/i33/4593.htm` • 3:04:05 – Sameer Dossani's Linktree (all links): `https://linktr.ee/SameerDossani` • 3:04:07 – Sameer Dossani's YouTube channel — @meatheels: `https://www.youtube.com/@MeatHeals` 🔥 This episode is sponsored by us -- Own Your Labs 👉 `https://ownyourlabs.com/sp/56` Private blood testing services 🩸Over 300 blood tests 💰Extremely affordable ❤️ We love our customers (Yes, we are literally funding the entire podcast from our own company -- so if you want to show your support, keep getting your private blood testing through our service. Thank you! 🙏) 🔗 CONNECT WITH DAVE FELDMAN: Main Channel: `https://youtube.com/@realDaveFeldman` X/Twitter: `https://x.com/realDaveFeldman` Instagram: `https://instagram.com/realDaveFeldman` Website: `https://thefeldmanprotocol.com` ⏱ Chapters 0:00 – Cold open and introduction 1:05 – Sameer's background and credentials 3:42 – Human origins and migration out of Africa 9:20 – Career in international economics and NGOs 15:34 – Ancient medicine and carbohydrate restriction 22:31 – Food culture, comfort eating, and self-soothing 34:12 – Human evolutionary diet: specialist vs. generalist 43:23 – Persistence hunting, sweat glands, and melanin 55:29 – Platform suppression and content challenges 1:03:03 – Sameer's personal health journey and diet shift 1:14:10 – Reaven's insulin resistance study and LDL findings 1:23:30 – Bradford Hill criteria and epidemiological data 1:33:09 – Minnesota Coronary experiment and withheld data 1:43:58 – Ketogenic diets, euketonemia, and fad diet framing 1:54:34 – LMHR study: plaque progression and CLEARLY analysis 2:04:27 – Statin pleiotropic effects and pharmaceutical trade-offs 2:18:20 – Own Your Labs Q&A: protein, muscle, and gut health 2:32:01 – Gut health, sleep, fatigue, and meal timing 2:46:26 – LMHR ketone production explained by Dave 2:52:04 – Changing the narrative: data, science, and next steps #FeldmanProtocol #DaveFeldman #SameerDossani #LeanMassHyperResponder #InsulinResistance #MetabolicHealth #LDL #Cholesterol #HumanEvolution #AncestralDiet #LowCarb #Ketogenic #AutoimmuneHealth #GutHealth #CholesterolCode #BloodWork #Carnivore #EpidemiologyDebate #ScientificMethod #HealthCoaching

In this episode of The Feldman Protocol, can the principles of metabolic flexibility reframe how athletes — and everyday people — think about fueling exercise? Dave Feldman sits down with Bronson Dant (metabolic performance coach and doctoral candidate in health science), who makes the case that food is function, not fuel. Bronson discusses his Army nutrition research experience, his carnivore diet journey and its effect on longstanding IBS, the distinction between fitness and health, oxidative priority debates, and emerging research on ketogenic adaptation timelines. 📎 Mentioned in this episode: • 2:18:58 – Clinical audit of Dr. Mark Cucuzella's VA low-carb nutrition program: `https://journalofmetabolichealth.org/index.php/jmh/article/view/141` • 3:00:37 – Bronson Dant & colleagues — substrate-corrected VO2 / movement economy paper: `https://journalofexerciseandnutrition.com/index.php/JEN/article/view/212` • 3:02:58 – Coach Bronson's website / coaching hub (coachbronson.com): `https://coachbronson.com/` • 3:03:04 – Coach Bronson — YouTube channel: `https://www.youtube.com/@coach.bronson` 🔥 This episode is sponsored by us -- Own Your Labs 👉 `https://ownyourlabs.com/sp/55` Private blood testing services 🩸Over 300 blood tests 💰Extremely affordable ❤️ We love our customers (Yes, we are literally funding the entire podcast from our own company -- so if you want to show your support, keep getting your private blood testing through our service. Thank you! 🙏) 🔗 CONNECT WITH DAVE FELDMAN: Main Channel: `https://youtube.com/@realDaveFeldman` X/Twitter: `https://x.com/realDaveFeldman` Instagram: `https://instagram.com/realDaveFeldman` Website: `https://thefeldmanprotocol.com` ⏱ Chapters 0:00 – Cold open & intro 1:15 – Bronson's background in fitness 6:36 – Decision to join the Army 11:04 – Army nutrition research at Natick Labs 20:57 – Transition from IT to CrossFit coaching 31:52 – Opening a gym: lessons learned 51:20 – Carnivore as an elimination approach 1:05:04 – IBS resolution and dietary change 1:21:56 – Coaching, identity & behavior change 1:34:22 – The 2020 disruption & rebuilding 1:46:43 – Systems thinking in nutrition science 1:56:37 – Metabolic flexibility: four components 2:04:06 – Ketogenic adaptation & performance research 2:18:09 – Virginia nutrition counseling audit findings 2:30:09 – Nutrition advice across training types 2:41:21 – Oxidative priority and food as function 2:50:26 – Glycogen storage, fat adaptation & RER 3:00:37 – Substrate-corrected VO2 research 3:02:53 – Where to find Bronson & closing thoughts #FeldmanProtocol #DaveFeldman #BronsonDant #MetabolicFlexibility #CarnivoreDiet #KetogenicDiet #SportsNutrition #LowCarbPerformance #FoodAsFunction #ExerciseScience #IBSRecovery #FatAdaptation #OxidativePriority #CrossFit #MetabolicHealth #NutritionCoaching #BloodWork #HealthOptimization

In this episode of The Feldman Protocol, what does emerging research actually reveal about cardiovascular risk in people who develop extreme LDL elevations on ketogenic diets — and how much remains genuinely unresolved? Zachary DiMattia (nutritional scientist, Penn State) joins Dave to discuss his published review on ketogenic diet–induced LDL elevations in normal-weight adults, presents preliminary findings from his controlled feeding study comparing low- and high-BMI responses to a ketogenic diet, and engages Dave in a frank debate over plaque progression data, the lipid hypothesis, and the novel regressor findings from the Keto-CTA cohort.🔥 This episode is sponsored by us --Own Your Labs 👉 `https://ownyourlabs.com/sp/54` Private blood testing services🩸Over 300 blood tests💰Extremely affordable❤️ We love our customers(Yes, we are literally funding the entire podcast from our own company -- so if you want to show your support, keep getting your private blood testing through our service. Thank you! 🙏)🔗 CONNECT WITH DAVE FELDMAN:Main Channel: `https://youtube.com/@realDaveFeldman`X/Twitter: `https://x.com/realDaveFeldman`Instagram: `https://instagram.com/realDaveFeldman`Website: `https://thefeldmanprotocol.com`⏱ Chapters0:00 – Cold open & key findings preview1:24 – Zachary's background intro5:02 – Path to nutrition research8:01 – Hashimoto's diagnosis journey13:27 – Elimination diet & gluten discovery21:49 – Interest in ketogenic LDL response26:03 – Penn State controlled feeding study design34:12 – Preliminary study results41:40 – Review paper overview51:04 – Lipid hypothesis steel-man debate1:05:49 – LMHR phenotype & clinical context1:18:35 – Proposed mechanisms beyond LEM1:26:14 – Keto-CTA plaque progression data1:40:41 – Regressor findings & noise floor1:49:09 – Miami Heart match analysis2:03:50 – Mechanisms: adiposity & cholesterol2:14:52 – Nature CT study comparison2:43:29 – Audience questions & closing thoughts#FeldmanProtocol #DaveFeldman #ZacharyDiMattia #LeanMassHyperResponder #KetogenicDiet #LDLCholesterol #Cardiovascular #Atherosclerosis #LipidResearch #NutritionalScience #CholesterolResearch #PlaqueProg #KetoCTA #LipidEnergyModel #Cardiometabolic #LowCarbResearch #Bloodwork #HeartHealth

In this episode of The Feldman Protocol, can what we eat meaningfully influence the course of serious mental illness? Dave sits down with Lauren Kennedy West (mental health advocate and YouTuber living with schizoaffective disorder) to explore her personal journey from multiple hospitalizations and misdiagnoses to adopting therapeutic ketosis. Lauren makes the case for metabolic psychiatry as a complement to traditional care, discusses the identity challenges of sharing her N-of-1 experiment publicly, reflects on navigating medication tapering, community polarization, the role of AI in personalized care, and the social complexity of restrictive eating.🔥 This episode is sponsored by us --Own Your Labs 👉 `https://ownyourlabs.com/sp/53` Private blood testing services🩸Over 300 blood tests💰Extremely affordable❤️ We love our customers(Yes, we are literally funding the entire podcast from our own company -- so if you want to show your support, keep getting your private blood testing through our service. Thank you! 🙏)🔗 CONNECT WITH DAVE FELDMAN:Main Channel: `https://youtube.com/@realDaveFeldman`X/Twitter: `https://x.com/realDaveFeldman`Instagram: `https://instagram.com/realDaveFeldman`Website: `https://thefeldmanprotocol.com`⏱ Chapters0:00 – Cold open & sucralose reaction1:14 – Lauren introduces herself2:46 – Early symptoms & the teenage years6:00 – First diagnosis journey8:20 – Hospitalizations & ECT11:46 – Dave's reflections on illness identity15:27 – YouTube channel origins19:32 – First attempt at ketogenic diet23:46 – Accessing metabolic psychiatry32:16 – Community reaction to going keto37:54 – Eating disorder concerns & food identity42:14 – The sushi experiment in San Francisco50:38 – Defined by wellness, not illness54:32 – Medication tapering & potentiation1:00:04 – Running, soccer & the ACL injury1:07:53 – Kids, diet, and parenting challenges1:17:00 – Metabolic Mind partnership & the course1:19:18 – Desk questions: dirty keto & sucralose1:23:08 – Meds vs. metabolic therapy: how it feels1:28:52 – Traveling keto & snack strategies1:39:31 – Community building & echo chambers1:47:42 – Social media, nuance & polarization1:58:11 – Platform challenges & demonetization2:05:53 – Patient autonomy & medical humility2:14:05 – Living well: nuance over narrative2:21:26 – AI in diagnostics & mental health care2:31:00 – AI sycophancy & trust concerns2:39:23 – The future of AI-assisted therapy2:46:09 – Parallels: AI guardrails & patient autonomy2:51:55 – Where to find Lauren#FeldmanProtocol #DaveFeldman #LaurenKennedyWest #MetabolicPsychiatry #KetogenicDiet #MentalHealth #Schizoaffective #SchizophreniaAwareness #BrainEnergy #TherapeuticKetosis #MentalWellness #NutritionAndMindHealth #AIInHealthcare #PatientAutonomy #LowCarbLife #ChristopherPalmer #MetabolicMind #MentalHealthAdvocacy

In this episode of The Feldman Protocol, how does metabolic health shape cardiovascular risk — and does the conventional focus on individual biomarkers miss the bigger picture? Dave Feldman sits down with cardiologist Arthur Agatston (MD), creator of the South Beach Diet and the coronary calcium score, to explore blood pressure guideline debates, insulin resistance and preeclampsia, the origins of the South Beach Diet, LP(a) and plaque progression in lean mass hyper-responders, HDL dysfunction, and the lipid energy model's structural hypothesis.🔥 This episode is sponsored by us --Own Your Labs 👉 `https://ownyourlabs.com/sp/52` Private blood testing services🩸Over 300 blood tests💰Extremely affordable❤️ We love our customers(Yes, we are literally funding the entire podcast from our own company -- so if you want to show your support, keep getting your private blood testing through our service. Thank you! 🙏)🔗 CONNECT WITH DAVE FELDMAN:Main Channel: `https://youtube.com/@realDaveFeldman`X/Twitter: `https://x.com/realDaveFeldman`Instagram: `https://instagram.com/realDaveFeldman`Website: `https://thefeldmanprotocol.com`⏱ Chapters0:00 – Introduction & cold open2:02 – Blood pressure monitoring technology6:57 – Dave & Arthur on BP guideline debates9:36 – Cholesterol targets & guideline pressures12:20 – Type 1 diabetes & low-carb care gaps15:26 – Joseph Kraft, insulin, and missed signals21:53 – Inertia in medicine & the role of AI27:06 – Insulin resistance, Kraft test & preeclampsia33:40 – Origins of the South Beach Diet40:17 – Carbohydrate addiction & personal experience51:32 – Elimination diets & unexpected symptom relief57:04 – Fat adaptation & lipoprotein dynamics1:00:00 – Triglycerides, remnant particles & VLDL1:05:11 – Particle size, ApoB & atherogenicity1:11:19 – LP(a) findings in lean mass hyper-responders1:19:45 – FH, plaque progression & LDL context1:33:31 – 4S trial, small dense LDL & statin data1:40:11 – HDL dysfunction & the HDL bump phenotype1:56:21 – Lipid energy model & structural hypothesis2:01:38 – Fat adaptation, F1, and closing reflections#FeldmanProtocol #DaveFeldman #ArthurAgatston #LipidEnergyModel #InsulinResistance #HeartHealth #CalciumScore #LDLCholesterol #MetabolicHealth #LowCarb #KetogenicDiet #ApoB #HDLDysfunction #Preeclampsia #SouthBeachDiet #Lipoproteins #CardiovascularResearch #FunctionalCardiology

In this episode of The Feldman Protocol, how does metabolic health shape cardiovascular risk — and what does that mean for interpreting cholesterol markers in lean, low-carb individuals? Arthur Agatston (MD) makes the case for a functional model of atherosclerosis progression, discusses AI-driven advances in cardiac imaging, argues for revisiting how blood pressure is measured and treated, and explores electrolyte management on ketogenic diets — all through a wide-ranging scientific conversation with Dave.🔥 This episode is sponsored by us --Own Your Labs 👉 `https://ownyourlabs.com/sp/51` Private blood testing services🩸Over 300 blood tests💰Extremely affordable❤️ We love our customers(Yes, we are literally funding the entire podcast from our own company -- so if you want to show your support, keep getting your private blood testing through our service. Thank you! 🙏)🔗 CONNECT WITH DAVE FELDMAN:Main Channel: `https://youtube.com/@realDaveFeldman`X/Twitter: `https://x.com/realDaveFeldman`Instagram: `https://instagram.com/realDaveFeldman`Website: `https://thefeldmanprotocol.com`⏱ Chapters0:00 – Cold open & intro7:11 – Late eating & metabolic effects12:37 – Western diet spreading globally18:07 – Personal fat threshold explained23:01 – Lipid energy model & LDL cycling30:26 – Exercise type & lipoprotein uptake38:39 – AI-enhanced cardiac imaging45:17 – Arterial flexibility & plaque burden53:20 – South Beach Diet origins1:00:39 – Scientific uncertainty in medicine1:06:41 – LMHR study: plaque findings1:16:57 – Plaque regression & calcification1:26:57 – Photon CT & next-gen imaging1:33:20 – Hypertension history & FDR1:41:30 – Blood pressure measurement issues1:49:44 – Keto, insulin & sodium loss1:55:09 – Overhydration & electrolyte balance2:00:08 – Electrolyte management on keto#FeldmanProtocol #DaveFeldman #ArthurAgatston #CardiovascularHealth #LowCarbDiet #LeanMassHyperResponder #LipidEnergyModel #HeartHealth #CACScore #KetogenicDiet #Atherosclerosis #BloodPressure #Electrolytes #MetabolicHealth #SouthBeachDiet #CardiacImaging #AIinMedicine #Cholesterol

In this episode of The Feldman Protocol, how well do conventional cardiovascular risk metrics actually identify who is truly at risk for a heart attack decades before it happens? Cardiologist Arthur Agatston (MD) makes the case for coronary calcium scoring as an early detection tool, discusses the natural history of atherosclerotic plaque, revisits key moments in lipid science history, explores why stent placement in asymptomatic patients presents a more complex picture than intuition suggests, and shares observations on the evolving role of CT angiography and AI-assisted plaque analysis. 🔥 This episode is sponsored by us -- Own Your Labs 👉 `https://ownyourlabs.com/sp/50` Private blood testing services 🩸Over 300 blood tests 💰Extremely affordable ❤️ We love our customers (Yes, we are literally funding the entire podcast from our own company -- so if you want to show your support, keep getting your private blood testing through our service. Thank you! 🙏) 🔗 CONNECT WITH DAVE FELDMAN: Main Channel: `https://youtube.com/@realDaveFeldman` X/Twitter: `https://x.com/realDaveFeldman` Instagram: `https://instagram.com/realDaveFeldman` Website: `https://thefeldmanprotocol.com` ⏱ Chapters 0:00 – Cold open & introduction 7:46 – Arthur's path into medicine 18:59 – Early cardiology & clinical trials 27:47 – Lipid science history & Ancel Keys 39:04 – Rabbit studies & lipoprotein discovery 47:15 – Ultra-fast CT arrives at Sinai 55:26 – Collateral vessels & total occlusion 1:00:00 – Ischemia trial: stents vs. medical therapy 1:05:01 – Back to the CAC origin story 1:13:09 – Soft vs. calcified plaque progression 1:21:40 – FH patient with zero CAC score 1:26:53 – The Agatston score is named 1:33:51 – Power of zero & plaque burden 1:39:35 – CAC vs. CT angiogram explained 1:44:19 – Resistance to new imaging technology 1:48:34 – Nutrition interest in the 1990s 1:49:25 – Heart Lung AI & plaque ratio research 1:51:11 – Closing reflections #FeldmanProtocol #DaveFeldman #ArthurAgatston #CoronaryCalcium #HeartHealth #Atherosclerosis #CardiacImaging #CACScore #LDL #Lipids #PlaqueBiology #CTAngiogram #CardiologyResearch #LowCarbDiet #LeanMassHyperResponder #HeartDiseasePrevention #LipidScience #CardiovascularResearch

In this episode of The Feldman Protocol, how does insulin influence cancer cell behavior — and what does that mean for metabolic approaches to the disease? Dave sits down with Isabella Cooper (PhD) to explore the glucose-ketone index and its practical limits, the role of glutamine alongside glucose in cancer metabolism, how mitochondrial dysfunction and cardiolipin loss may relate to tumor progression, the case for high-dose intravenous vitamin C, osteocyte biology and the surprising systemic roles of osteocalcin, and what makes a rigorous research culture. 🔥 This episode is sponsored by us -- Own Your Labs 👉 `https://ownyourlabs.com/sp/49` Private blood testing services 🩸Over 300 blood tests 💰Extremely affordable ❤️ We love our customers (Yes, we are literally funding the entire podcast from our own company -- so if you want to show your support, keep getting your private blood testing through our service. Thank you! 🙏) 🔗 CONNECT WITH DAVE FELDMAN: Main Channel: `https://youtube.com/@realDaveFeldman` X/Twitter: `https://x.com/realDaveFeldman` Instagram: `https://instagram.com/realDaveFeldman` Website: `https://thefeldmanprotocol.com` ⏱ Chapters 0:00 – Cold open & intro 1:08 – Cancer metabolism overview 2:24 – Glucose-ketone index explained 5:01 – Lean mass hypersponders & glucose 9:18 – Acetone measurement & respiration 13:49 – Insulin, ketones & cancer signaling 19:05 – Growth factors & VEGF discussion 25:29 – Stomach acidity & nutrient absorption 32:08 – How cancer cells originate 35:43 – Cardiolipin, melatonin & apoptosis 43:05 – Diet quality & food as function 52:14 – Chemotherapy & metabolic protocols 1:03:36 – Patient outcomes & biopsy risks 1:14:32 – IV vitamin C trial findings 1:22:07 – Ideal cancer metabolism trial design 1:29:36 – Sunlight, melanin & mitochondria 1:37:20 – Osteocyte biology & osteocalcin 1:46:43 – Research culture & scientific rigor 1:54:36 – Most underappreciated biomarker #FeldmanProtocol #DaveFeldman #IsabellaCooper #CancerMetabolism #KetogenicDiet #Mitochondria #Insulin #GlucoseKetoneIndex #Osteocalcin #IntravenousVitaminC #Ketosis #MetabolicHealth #LowCarbScience #CancerResearch #Cardiolipin #Osteocytes #BloodWork #Hyperinsulinemia #MitochondrialHealth #PodcastScience

In this episode of The Feldman Protocol, what does beta-hydroxybutyrate between meals actually reveal about a person's insulin state — and why might that matter for understanding chronic disease risk? Dave sits down with Isabella Cooper (PhD), a biochemistry and pathophysiology scientist whose research spans assay quality control, hyperinsulinemia detection, ketone thresholds, mitochondrial function, and the lipid energy model, making the case that personalized insulin thresholds — not population-wide cutoffs — may be key to identifying subclinical metabolic dysfunction.🔥 This episode is sponsored by us --Own Your Labs 👉 `https://ownyourlabs.com/sp/48` Private blood testing services🩸Over 300 blood tests💰Extremely affordable❤️ We love our customers(Yes, we are literally funding the entire podcast from our own company -- so if you want to show your support, keep getting your private blood testing through our service. Thank you! 🙏)🔗 CONNECT WITH DAVE FELDMAN:Main Channel: `https://youtube.com/@realDaveFeldman`X/Twitter: `https://x.com/realDaveFeldman`Instagram: `https://instagram.com/realDaveFeldman`Website: `https://thefeldmanprotocol.com`⏱ Chapters0:00 – Cold open & intro1:06 – Isabella's background & credentials3:05 – East-meets-West medicine upbringing5:43 – Ballet, modeling & low-carb insights6:36 – Industrial design degree & lab thinking8:58 – Assay quality problems in undergrad lab12:08 – Coefficient of variation explained17:01 – Standardizing vortex & sample handling27:30 – Back to timeline: the 15-year gap39:52 – Pregnancy, diapers & toxicology deep dive53:06 – Old physiology papers vs modern science1:00:05 – Osteocalcin hypothesis & being wrong1:06:48 – Ben Bikman, mitochondria & insulin1:19:40 – Headwinds for low-carb research1:34:19 – Personalized insulin threshold concept1:41:28 – Beta-hydroxybutyrate as insulin surrogate1:51:44 – Leptin, IGF-1 & multi-marker detection2:09:09 – Subclinical hyperinsulinemia marker cluster2:14:20 – Fasting, lipid dynamics & VLDL traffic#FeldmanProtocol #DaveFeldman #IsabellaCooper #Hyperinsulinemia #Ketosis #Mitochondria #MetabolicHealth #InsulinResistance #BetaHydroxybutyrate #LowCarb #ChronicDisease #LipidEnergyModel #AssayQuality #KetoneThreshold #LaboratoryScience #Bioenergetics #BloodTesting #Inflammation

In this episode of The Feldman Protocol, how much does metabolic health shape cardiovascular risk beyond what standard lipid markers can reveal? Dave Feldman sits down with Scott Murray (MD), a UK-based interventional cardiologist, to explore plaque imaging and its limitations, the role of visceral and perivascular fat in heart disease, the lipid energy model and lean mass hyper-responders, cardiac fuel metabolism and heart failure with preserved ejection fraction, and the challenges of conducting and interpreting cardiovascular trials. 🔥 This episode is sponsored by us -- Own Your Labs 👉 `https://ownyourlabs.com/sp/47` Private blood testing services 🩸Over 300 blood tests 💰Extremely affordable ❤️ We love our customers (Yes, we are literally funding the entire podcast from our own company -- so if you want to show your support, keep getting your private blood testing through our service. Thank you! 🙏) 🔗 CONNECT WITH DAVE FELDMAN: Main Channel: `https://youtube.com/@realDaveFeldman` X/Twitter: `https://x.com/realDaveFeldman` Instagram: `https://instagram.com/realDaveFeldman` Website: `https://thefeldmanprotocol.com` ⏱ Chapters 0:00 – Cold open & Scott's intro 14:21 – Scott's cardiology practice 17:28 – Invasive vs. CT angiography 24:49 – Collaterals & microvascular function 34:31 – Glycocalyx & endothelial health 40:28 – Perivascular fat & imaging 51:14 – Imaging, CAC, and plaque noise 1:00:04 – Lipid hypothesis & population context 1:07:05 – CT plaque measurement variability 1:19:42 – Perivascular inflammation & Caristo scoring 1:29:07 – Lipid energy model discussion 1:49:43 – LP(a), acute-phase markers & reverse causation 2:05:01 – LMHR study timeline & next scans 2:22:57 – Heart fuel preference & HFpEF 2:39:08 – PCSK9 trials & all-cause mortality 2:52:06 – Run-in periods & trial design concerns 3:05:00 – Context, guidelines & patient conversations 3:17:35 – GLP-1 peptides & obesity biology 3:26:28 – Where to find Scott & closing thoughts #FeldmanProtocol #DaveFeldman #ScottMurray #PreventiveCardiology #HeartHealth #LipidHypothesis #LeanMassHyperResponder #CTAngiography #PlaqueImaging #CardiovascularResearch #MetabolicHealth #LipidEnergyModel #HeartFailure #LPa #GLP1 #TrialDesign #Cardiology #LowCarb #BloodWork

In this episode of The Feldman Protocol, what actually drives cardiovascular disease in a metabolically healthy, lean individual — and is elevated LDL the most important variable to consider? Darius Sharpe (ER nurse and lean mass hypersponder community member) discusses his unexpected CAC score at age 38, his theory on postprandial glucose and vascular damage, a personal episode of atrial fibrillation, the Keto CTA study's Clearly data controversy, and what ER nurses observe firsthand about metabolic illness. 🔥 This episode is sponsored by us -- Own Your Labs 👉 `https://ownyourlabs.com/sp/43` Private blood testing services 🩸Over 300 blood tests 💰Extremely affordable ❤️ We love our customers (Yes, we are literally funding the entire podcast from our own company -- so if you want to show your support, keep getting your private blood testing through our service. Thank you! 🙏) 🔗 CONNECT WITH DAVE FELDMAN: Main Channel: `https://youtube.com/@realDaveFeldman` X/Twitter: `https://x.com/realDaveFeldman` Instagram: `https://instagram.com/realDaveFeldman` Website: `https://thefeldmanprotocol.com` ⏱ Chapters 0:00 – Cold open & CAC score reveal 4:51 – Darius's CAC scan background 9:07 – First-phase insulin response explained 15:47 – CAC result context & vessel findings 22:09 – Darius investigates his own cardiac risk 33:43 – Atrial fibrillation episode & AFIB physiology 43:28 – Electrolytes, magnesium, and sodium discussion 51:04 – Stress tests vs. imaging: a patient case 58:01 – Metabolic syndrome underdiagnosis in hospitals 1:03:09 – Dave's diet experiments & LMHR data 1:09:18 – Fat bomb experiment: NMR findings 1:20:53 – Lipid energy model & structural hypothesis 1:30:37 – Keto CTA: plaque associations & progressors 1:39:41 – Clearly data controversy & scientific transparency 1:51:55 – Glucose, hyperglycemia, and plaque theory 2:05:22 – Raw data release & cards on the table 2:15:01 – ER realities & medication safety 2:29:07 – Lifestyle, habits, and the ER patient perspective 2:39:10 – Where to find Darius & closing thoughts #FeldmanProtocol #DaveFeldman #DariusSharpe #LeanMassHypersponder #KetoCTA #CACScore #AtrialFibrillation #PostprandialGlucose #MetabolicSyndrome #LipidEnergyModel #CardiovascularHealth #CGM #LDL #InsulinResponse #ERNurse #BloodTesting #HeartHealth #NMRPanel

In this episode of The Feldman Protocol, how well does the prevailing understanding of LDL and cardiovascular disease hold up under close scrutiny? Dave sits down with Malcolm Kendrick (MD) — author, researcher, and longtime cardiovascular disease skeptic — who challenges key assumptions across trial methodology, observational data, Mendelian randomization, clinical trial blinding, nitric oxide's role in vascular health, and the response-to-injury model of atherosclerosis.🔥 This episode is sponsored by us --Own Your Labs 👉 `https://ownyourlabs.com/sp/46` Private blood testing services🩸Over 300 blood tests💰Extremely affordable❤️ We love our customers(Yes, we are literally funding the entire podcast from our own company -- so if you want to show your support, keep getting your private blood testing through our service. Thank you! 🙏)🔗 CONNECT WITH DAVE FELDMAN:Main Channel: `https://youtube.com/@realDaveFeldman`X/Twitter: `https://x.com/realDaveFeldman`Instagram: `https://instagram.com/realDaveFeldman`Website: `https://thefeldmanprotocol.com`⏱ Chapters0:00 – Introduction & cold open1:11 – Malcolm Kendrick's background6:02 – Early contrarian tendencies in medicine16:48 – International cholesterol skeptic network22:13 – Shifting LDL targets over decades39:05 – FH, heterozygous vs. homozygous49:35 – Examining pharmaceutical trial evidence57:00 – Clinical trial blinding & composite endpoints1:07:27 – Data transparency & CTT access questions1:23:11 – Statins, nitric oxide & plausible mechanisms1:37:34 – Mendelian randomization discussed1:54:43 – Audience questions: ApoB & endothelial injury2:05:24 – Kendrick's cardiovascular disease model2:19:44 – Shared models: vascular repair & hemostasis2:38:39 – The Daily Mail lawsuit: origins2:47:32 – Five-year legal battle & court proceedings3:00:01 – CTT emails & trial methodology concerns3:17:29 – LMHR study update & CLEARLY retraction3:33:23 – Where to find Malcolm Kendrick#FeldmanProtocol #DaveFeldman #MalcolmKendrick #CardiovascularDisease #LDLCholesterol #LipidHypothesis #ClinicalTrials #NitricOxide #Atherosclerosis #StatinResearch #HeartHealth #LeanMassHyperresponder #CholesterolDebate #ApoB #MetabolicHealth #EvidenceBasedMedicine #TrialMethodology #Cholesterol