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Fireside Chats in Individual Medicines brings together experts at the forefront of individualized medicines to have candid discussions about relevant topics and practical challenges involved in advancing these pioneering therapies. Episodes feature leaders across industry and academia sharing real-world experiences and lessons learned to help the field overcome hurdles on the path to providing individualized treatments for patients. N1C Fireside Chats Disclaimer Fireside Chats in Individualized Medicines is a podcast hosted by the N=1 Collaborative. This podcast is the work product of the N=1 Collaborative, a group of researchers and practitioners who share their expertise and experience in individualized medicine. This podcast hosts individuals from multiple organizations and is intended to provide information for research and educational purposes only and is expressly not intended to provide legal, clinical, or professional advice which should be sought separately by qualified practitioners. The information and views shared in the podcast are based on the best available knowledge and practice at the time of publication. The N1C reserves the right to update, modify, or withdraw content at any time without prior notice. Listeners of these podcasts should exercise their own judgment and discretion in applying these practices to their specific situations.

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Check latest episodes from Fireside Chats in Individual Medicines podcast

Barriers Beyond Biology

2026/02/18

Fireside Chats in Individual Medicines brings together experts at the forefront of individualized medicines to have candid discussions about relevant topics and practical challenges involved in advancing these pioneering therapies. In this episode, we feature: Lynn Bush, PhD, MS Bioethics, MAElizabeth Berry-Kravis, MD, PhDEmily McCourt, MDYael Shiloh-Malawsky, M.D.Fireside Chats in Individualized Medicines is a podcast hosted by the N=1 Collaborative. This podcast is the work product of the N=1 Collaborative, a group of researchers and practitioners who share their expertise and experience in individualized medicine. This podcast hosts individuals from multiple organizations and is intended to provide information for research and educational purposes only and is expressly not intended to provide legal, clinical, or professional advice which should be sought separately by qualified practitioners. The information and views shared in the podcast are based on the best available knowledge and practice at the time of publication. The N1C reserves the right to update, modify, or withdraw content at any time without prior notice. Listeners of these podcasts should exercise their own judgment and discretion in applying these practices to their specific situations.

Inside the Thorny Trench

2026/01/15

Fireside Chats in Individual Medicines brings together experts at the forefront of individualized medicines to have candid discussions about relevant topics and practical challenges involved in advancing these pioneering therapies. In this episode, we feature: Lynn Bush, PhD, MS Bioethics, MAWendy Chung, MD, PhDGregory Costain, MD, PhDAustin Larson, M.D.Olivia Kim-McManus, M.D.Fireside Chats in Individualized Medicines is a podcast hosted by the N=1 Collaborative. This podcast is the work product of the N=1 Collaborative, a group of researchers and practitioners who share their expertise and experience in individualized medicine. This podcast hosts individuals from multiple organizations and is intended to provide information for research and educational purposes only and is expressly not intended to provide legal, clinical, or professional advice which should be sought separately by qualified practitioners. The information and views shared in the podcast are based on the best available knowledge and practice at the time of publication. The N1C reserves the right to update, modify, or withdraw content at any time without prior notice. Listeners of these podcasts should exercise their own judgment and discretion in applying these practices to their specific situations.

The Weight of the Unknown

2025/12/11

Fireside Chats in Individual Medicines brings together experts at the forefront of individualized medicines to have candid discussions about relevant topics and practical challenges involved in advancing these pioneering therapies. In this episode, we feature: Lynn Bush, PhD, MS Bioethics, MAAnnemieke Aartsma-Rus, Ph.D.Rebecca Schüle, M.D.Claudio Melo De Gusmao, MD, PhDFireside Chats in Individualized Medicines is a podcast hosted by the N=1 Collaborative. This podcast is the work product of the N=1 Collaborative, a group of researchers and practitioners who share their expertise and experience in individualized medicine. This podcast hosts individuals from multiple organizations and is intended to provide information for research and educational purposes only and is expressly not intended to provide legal, clinical, or professional advice which should be sought separately by qualified practitioners. The information and views shared in the podcast are based on the best available knowledge and practice at the time of publication. The N1C reserves the right to update, modify, or withdraw content at any time without prior notice. Listeners of these podcasts should exercise their own judgment and discretion in applying these practices to their specific situations.

It Takes a Village

2025/05/08

Fireside Chats in Individual Medicines brings together experts at the forefront of individualized medicines to have candid discussions about relevant topics and practical challenges involved in advancing these pioneering therapies. In this episode, we feature: Marlen Lauffer, M.D.Dalila SabaredzovicDavid Silver, PhDRoxana Redis, Ph.D.David Fischer, Ph.D.Tim Yu, M.D., PhDFireside Chats in Individualized Medicines is a podcast hosted by the N=1 Collaborative. This podcast is the work product of the N=1 Collaborative, a group of researchers and practitioners who share their expertise and experience in individualized medicine. This podcast hosts individuals from multiple organizations and is intended to provide information for research and educational purposes only and is expressly not intended to provide legal, clinical, or professional advice which should be sought separately by qualified practitioners. The information and views shared in the podcast are based on the best available knowledge and practice at the time of publication. The N1C reserves the right to update, modify, or withdraw content at any time without prior notice. Listeners of these podcasts should exercise their own judgment and discretion in applying these practices to their specific situations.

Scaling n-of-1 Therapies: From One to Many

2025/03/24

Fireside Chats in Individual Medicines brings together experts at the forefront of individualized medicines to have candid discussions about relevant topics and practical challenges involved in advancing these pioneering therapies. In this episode, we feature: Steven RingelJeff MiltonScott Demarest, M.D.Marlen Lauffer, M.D.Annemieke Aartsma-Rus, Ph.D.Fireside Chats in Individualized Medicines is a podcast hosted by the N=1 Collaborative. This podcast is the work product of the N=1 Collaborative, a group of researchers and practitioners who share their expertise and experience in individualized medicine. This podcast hosts individuals from multiple organizations and is intended to provide information for research and educational purposes only and is expressly not intended to provide legal, clinical, or professional advice which should be sought separately by qualified practitioners. The information and views shared in the podcast are based on the best available knowledge and practice at the time of publication. The N1C reserves the right to update, modify, or withdraw content at any time without prior notice. Listeners of these podcasts should exercise their own judgment and discretion in applying these practices to their specific situations.

Beyond the Data: Author Insights on N-of-1 Trials in Precision Medicine

2025/03/11

Fireside Chats in Individual Medicines brings together experts at the forefront of individualized medicines to have candid discussions about relevant topics and practical challenges involved in advancing these pioneering therapies. In this episode, we feature: Scott Demarest, M.D.Tim Yu, M.D., PhDOlivia Kim-McManus, M.D.Richard Finkel, M.D.Fireside Chats in Individualized Medicines is a podcast hosted by the N=1 Collaborative. This podcast is the work product of the N=1 Collaborative, a group of researchers and practitioners who share their expertise and experience in individualized medicine. This podcast hosts individuals from multiple organizations and is intended to provide information for research and educational purposes only and is expressly not intended to provide legal, clinical, or professional advice which should be sought separately by qualified practitioners. The information and views shared in the podcast are based on the best available knowledge and practice at the time of publication. The N1C reserves the right to update, modify, or withdraw content at any time without prior notice. Listeners of these podcasts should exercise their own judgment and discretion in applying these practices to their specific situations.

Visionary Science: Charting a Path for Mutation-Based Retinal Interventions

2025/01/06

Fireside Chats in Individual Medicines brings together experts at the forefront of individualized medicines to have candid discussions about relevant topics and practical challenges involved in advancing these pioneering therapies. In this episode, we feature: Rob Collin, Ph.D.Roger Paxton, Ph.D.Scott Henry, Ph.D.Annemieke Aartsma-Rus, Ph.D.Tim Yu, MD, PhDFireside Chats in Individualized Medicines is a podcast hosted by the N=1 Collaborative. This podcast is the work product of the N=1 Collaborative, a group of researchers and practitioners who share their expertise and experience in individualized medicine. This podcast hosts individuals from multiple organizations and is intended to provide information for research and educational purposes only and is expressly not intended to provide legal, clinical, or professional advice which should be sought separately by qualified practitioners. The information and views shared in the podcast are based on the best available knowledge and practice at the time of publication. The N1C reserves the right to update, modify, or withdraw content at any time without prior notice. Listeners of these podcasts should exercise their own judgment and discretion in applying these practices to their specific situations.

Molecules and Methods: Reevaluating ASO Biodistribution to the Brain

2024/09/26

Fireside Chats in Individual Medicines brings together experts at the forefront of individualized medicines to have candid discussions about relevant topics and practical challenges involved in advancing these pioneering therapies. In this episode, we feature: Charles Berde, M.D., Ph.D.Joseph Madsen, M.D.Bryn Martin, Ph.D.Kathrin Meyer, Ph.D.Roxana Redis, Ph.D.Willeke can Roon-Mom, Ph.D.Fireside Chats in Individualized Medicines is a podcast hosted by the N=1 Collaborative. This podcast is the work product of the N=1 Collaborative, a group of researchers and practitioners who share their expertise and experience in individualized medicine. This podcast hosts individuals from multiple organizations and is intended to provide information for research and educational purposes only and is expressly not intended to provide legal, clinical, or professional advice which should be sought separately by qualified practitioners. The information and views shared in the podcast are based on the best available knowledge and practice at the time of publication. The N1C reserves the right to update, modify, or withdraw content at any time without prior notice. Listeners of these podcasts should exercise their own judgment and discretion in applying these practices to their specific situations.

Behind the Publication: Author Insights on 'How to Pay for Individualized Genetic Medicines'

2024/08/30

Fireside Chats in Individual Medicines brings together experts at the forefront of individualized medicines to have candid discussions about relevant topics and practical challenges involved in advancing these pioneering therapies. In this episode, our featured guests discuss the topic of "How to Pay for Individualized Genetic Medicines" Timothy Yu, M.D., Ph.D.Andrew Lo, Ph.D.Julia Pian, M.D.Deanna Portero, MPH/MBA CandidateFireside Chats in Individualized Medicines is a podcast hosted by the N=1 Collaborative. This podcast is the work product of the N=1 Collaborative, a group of researchers and practitioners who share their expertise and experience in individualized medicine. This podcast hosts individuals from multiple organizations and is intended to provide information for research and educational purposes only and is expressly not intended to provide legal, clinical, or professional advice which should be sought separately by qualified practitioners. The information and views shared in the podcast are based on the best available knowledge and practice at the time of publication. The N1C reserves the right to update, modify, or withdraw content at any time without prior notice. Listeners of these podcasts should exercise their own judgment and discretion in applying these practices to their specific situations.

Smarter Ways to Identify Treatment Targets

2024/07/08

Fireside Chats in Individual Medicines brings together experts at the forefront of individualized medicines to have candid discussions about relevant topics and practical challenges involved in advancing these pioneering therapies. In this episode, we feature: Logan Newton, M.S.Annemieke Aartsma-Rus, Ph.D.Bush, Lynn, Ph.D., M.S. Bioethics, M.A. Marlen Lauffer, M.D.Willeke van Roon-Mom, Ph.D.Fireside Chats in Individualized Medicines is a podcast hosted by the N=1 Collaborative. This podcast is the work product of the N=1 Collaborative, a group of researchers and practitioners who share their expertise and experience in individualized medicine. This podcast hosts individuals from multiple organizations and is intended to provide information for research and educational purposes only and is expressly not intended to provide legal, clinical, or professional advice which should be sought separately by qualified practitioners. The information and views shared in the podcast are based on the best available knowledge and practice at the time of publication. The N1C reserves the right to update, modify, or withdraw content at any time without prior notice. Listeners of these podcasts should exercise their own judgment and discretion in applying these practices to their specific situations.

Finding the Balance: Urgency, Rigor, and Uncertainty in Lead Optimization

2024/06/17

Fireside Chats in Individual Medicines brings together experts at the forefront of individualized medicines to have candid discussions about relevant topics and practical challenges involved in advancing these pioneering therapies. In this episode, we feature: Casey McPhersonJennifer San Miguel, Ph.D.Michael Templin, Ph.D., DABTRoxana Redis, Ph.D.Willeke van Roon-Mom, Ph.D.Robert Cabrera, Ph.D.Fireside Chats in Individualized Medicines is a podcast hosted by the N=1 Collaborative. This podcast is the work product of the N=1 Collaborative, a group of researchers and practitioners who share their expertise and experience in individualized medicine. This podcast hosts individuals from multiple organizations and is intended to provide information for research and educational purposes only and is expressly not intended to provide legal, clinical, or professional advice which should be sought separately by qualified practitioners. The information and views shared in the podcast are based on the best available knowledge and practice at the time of publication. The N1C reserves the right to update, modify, or withdraw content at any time without prior notice. Listeners of these podcasts should exercise their own judgment and discretion in applying these practices to their specific situations.

When is Enough Enough?

2024/03/13

Fireside Chats in Individual Medicines brings together experts at the forefront of individualized medicines to have candid discussions about relevant topics and practical challenges involved in advancing these pioneering therapies. In this episode, we feature: Thomas LaRocca, MD, PhDAnnemieke Aartsma-Rus, PhDWilleke van Roon-Mom, PhDMarlen Lauffer, MD, PhDTim Yu, MD, PhD Fireside Chats in Individualized Medicines is a podcast hosted by the N=1 Collaborative. This podcast is the work product of the N=1 Collaborative, a group of researchers and practitioners who share their expertise and experience in individualized medicine. This podcast hosts individuals from multiple organizations and is intended to provide information for research and educational purposes only and is expressly not intended to provide legal, clinical, or professional advice which should be sought separately by qualified practitioners. The information and views shared in the podcast are based on the best available knowledge and practice at the time of publication. The N1C reserves the right to update, modify, or withdraw content at any time without prior notice. Listeners of these podcasts should exercise their own judgment and discretion in applying these practices to their specific situations.