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Dr. Ian Kelleher (University of Edinburgh, Scotland) joins AJP Audio to discuss an emulated target trial looking at the prophylactic qualities of doxycycline, an antibiotic, in an adolescent population at risk to develop schizophrenia spectrum disorder.  Afterwards, AJP Editor-in-Chief Dr. Ned Kalin joins the podcast to put the rest of the issue into context. 00:53   Doxycycline and the risk of developing schizophrenia 04:03   Emulated target trials versus randomized control trials 06:43   Methods of action 09:24   Dosage and exposure levels for doxycycline 10:15   Immediate clinical applications 10:56   Limitations of the study 11:33   Future research 12:43   Kalin interview 13:00   Lång et al. 19:43   Zhao et al. 25:20   Metrik et al. Transcript Be sure to let your colleagues know about the podcast, and please rate and review it on Apple Podcasts, Google Podcasts, Spotify, or wherever you listen to it. Subscribe to the podcast here. Listen to other podcasts produced by the American Psychiatric Association. Browse articles online. How authors may submit their work. Follow the journals of APA Publishing on Twitter. E-mail us at [email protected]

This special episode of AJP Audio brings together the editors of the American Journal Psychiatry and the AJP Residents' Journal to discuss important and impactful articles published in 2025. 00:39   Ned H. Kalin, M.D., discusses "Transcriptomic Analysis of the Human Habenula in Schizophrenia" by Ege A. Yalcinbas, Ph.D., et al. 06:23   Elisabeth Binder, M.D., Ph.D., discusses "Copy Number Variant Architecture of Child Psychopathology and Cognitive Development in the ABCD Study" by Zhiqiang Sha, Ph.D., et al. 11:17   Kathleen T. Brady, M.D., Ph.D., discusses "High-Potency Cannabis Use and Health: A Systematic Review of Observational and Experimental Studies" by Stephanie Lake, Ph.D., et al. 15:35   David A. Lewis, M.D., discusses "20 Years of Aberrant Salience in Psychosis: What Have We Learned?" by Philip R. Corlett, Ph.D., and Kurt M. Fraser, Ph.D. 17:27   William M. McDonald, M.D., discusses "Psychedelics for the Treatment of Psychiatric Disorders: Interpreting and Translating Available Evidence and Guidance for Future Research" by Roger S. McIntyre, M.D., F.R.C.P.C., et al. 24:04   Daniel S. Pine, M.D., discusses "Cognitive Behavioral Therapy and Lisdexamfetamine, Alone and Combined, for Binge-Eating Disorder With Obesity: A Randomized Controlled Trial" by Carlos M. Grilo, Ph.D., et al. 26:06   Carolyn Rodriguez, M.D., Ph.D., discusses "Randomized Controlled Trial of the Effects of High-Dose Ondansetron on Clinical Symptoms and Brain Connectivity in Obsessive-Compulsive and Tic Disorders" by Emily R. Stern, Ph.D., et al. 30:26   Sean T. Lynch, M.D., discusses "From Medical Practice to Mass Incarceration: A Historical Analysis of Racial and Ethnic Targeting in U.S. Drug Policy" by Rathisha Pathmathasan, D.O., et al. Transcript Be sure to let your colleagues know about the podcast, and please rate and review it on Apple Podcasts, Google Podcasts, Spotify, or wherever you listen to it. Subscribe to the podcast here. Listen to other podcasts produced by the American Psychiatric Association. Browse articles online. How authors may submit their work. Follow the journals of APA Publishing on Twitter. E-mail us at [email protected]  

Dr. Julia Linke (University of Mainz, Germany) joins AJP Audio to discuss the use of neural efficiency, a measure of brain activity, as a potential biomarker in the treatment of children with anxiety disorder.  Afterwards, AJP Editor-in-Chief Dr. Ned Kalin joins the podcast to put the rest of the issue into context. 00:31   Linke interview 02:15   State or a trait? 04:15   Neural efficiency and CBT 05:22   Potential as a biomarker 07:08   Patient-rated and parent-rated measures of anxiety 08:16   Immediate clinical implications 09:50   Limitations 10:43   Future directions of research 11:44   Kalin interview 11:50   Linke et al. 15:16   Mallard et al. 18:11   Naples et al. 21:44   Mac Giollabhui et al. Transcript Be sure to let your colleagues know about the podcast, and please rate and review it on Apple Podcasts, Google Podcasts, Spotify, or wherever you listen to it. Subscribe to the podcast here. Listen to other podcasts produced by the American Psychiatric Association. Browse articles online. How authors may submit their work. Follow the journals of APA Publishing on Twitter. E-mail us at [email protected]

Dr. Suresh Durgam (Intra-Cellular Therapies, a Johnson & Johnson Company, Bedminster, NJ) joins AJP Audio to discuss a phase 3 randomized controlled trial looking at the use of the antipsychotic medication lumateperone as adjunctive to antidepressant therapy in the treatment of patients with major depressive disorder. Afterwards, AJP Editor-in-Chief Dr. Ned Kalin discusses the rest of the December issue of the Journal. 00:48   Durgam interview 03:09   Mechanism of action 04:44   Patient-reported outcomes 06:31   Immediate clinical implications 07:32   Limitations 08:08   Further research 09:25   Kalin interview 09:38   Durgam et al. 13:09   Lin et al. 17:22   Brodsky et al. Transcript Be sure to let your colleagues know about the podcast, and please rate and review it on Apple Podcasts, Google Podcasts, Spotify, or wherever you listen to it. Subscribe to the podcast here. Listen to other podcasts produced by the American Psychiatric Association. Browse articles online. How authors may submit their work. Follow the journals of APA Publishing on Twitter. E-mail us at [email protected]

Dr. Lara Coughlin (University of Michigan, Ann Arbor) joins AJP Audio to discuss a study looking the impact of contingency management on all cause mortality in patients with stimulant use disorder. Afterwards, AJP Editor-in-Chief Dr. Ned Kalin discusses the rest of the November issue of the Journal. 01:09   Coughlin interview 02:05   Stimulant use disorder and contingency management 04:37   Mortality 05:12   Contingency management and "moral hazard" 08:30   Clinical uptake of contingency management 09:28   Broader applicability to psychiatric conditions 10:31   Limitations 11:39   Further research 12:32   Kalin interview 12:49   Coughlin et al. 16:41   Yalcinbas et al. 22:22   Na et al. Transcript Be sure to let your colleagues know about the podcast, and please rate and review it on Apple Podcasts, Google Podcasts, Spotify, or wherever you listen to it. Subscribe to the podcast here. Listen to other podcasts produced by the American Psychiatric Association. Browse articles online. How authors may submit their work. Follow the journals of APA Publishing on Twitter. E-mail us at [email protected]

Dr. Shau-Ming Wei (National Institute of Mental Health, Bethesda, MD) joins AJP Audio to discuss a replication study looking at impact of hormone addback to a hormone suppression regimen for the treatment of premenstrual dysphoric disorder. Afterwards, AJP Editor-in-Chief Dr. Ned Kalin discusses the rest of the October issue of the Journal.  00:34   Wei interview 02:59   PMDD 04:22   Up and downsides of hormone suppression 05:52   Hormone addback 07:15   Limitations of the current study 08:38   Further research 10:42   Kalin interview 10:58   Wei et al. 15:25   Sanacora et al. 20:07   Whittle et al. 23:06   Cooper et al. Transcript Be sure to let your colleagues know about the podcast, and please rate and review it on Apple Podcasts, Google Podcasts, Spotify, or wherever you listen to it. Subscribe to the podcast here. Listen to other podcasts produced by the American Psychiatric Association. Browse articles online. How authors may submit their work. Follow the journals of APA Publishing on Twitter. E-mail us at [email protected]

Dr. Deidre Anglin (City College, CUNY, New York) joins AJP Audio to discuss the disparate impact of schizophrenia spectrum disorder diagnosis on racial and ethnic minorities in the United States based on localized neighborhood data. Afterwards, AJP Editor-in-Chief Dr. Ned Kalin discusses the rest of the September issue of the Journal. 00:31   Anglin interview 04:40   Zip code sizes 05:18   The long legacy of redlining 07:17   Socially vulnerable neighborhoods 09:43   Structural racism, clinicians, and working with individuals 13:45   Limitations 15:56   Further research 18:08   Kalin interview 18:13   Anglin et al. 25:19   Vano et al. 29:40   Moussa-Tooks et al. 33:34   Zhang et al. Transcript Be sure to let your colleagues know about the podcast, and please rate and review it on Apple Podcasts, Google Podcasts, Spotify, or wherever you listen to it. Subscribe to the podcast here. Listen to other podcasts produced by the American Psychiatric Association. Browse articles online. How authors may submit their work. Follow the journals of APA Publishing on Twitter. E-mail us at [email protected]

Dr. Vinod Rao (Massachusetts General Hospital, Boston) join AJP Audio to discuss predicting the relative risk of patients with an ADHD diagnosis developing a later stimulant or substance use disorder based on the method of prescription, in person or via telehealth. Afterwards, AJP Editor-in-Chief Dr. Ned Kalin discusses the rest of the August issue of the Journal. 00:07   Rao interview 01:53   Stimulant use disorder versus substance use disorder 02:59   Cohort size and incidence of SUDs 04:28   Length of clinician engagement in non-profit versus for profit hospital systems 05:18   Patient cohort 06:20   Potential difference in mechanism between prescribing practices 07:35   Continued use of telehealth 08:43   Limitations 10:03   Further research 11:17   Kalin interview 11:24   Rao et al. 15:41   Mahjani et al. 19:59   Zhang et al. 25:11   Sha et al. 29:33   Gao and Olfson Transcript Be sure to let your colleagues know about the podcast, and please rate and review it on Apple Podcasts, Google Podcasts, Spotify, or wherever you listen to it. Subscribe to the podcast here. Listen to other podcasts produced by the American Psychiatric Association. Browse articles online. How authors may submit their work. Follow the journals of APA Publishing on Twitter. E-mail us at [email protected]

Dr. Tanner Bommersbach (University of Wisconsin School of Medicine and Public Health) and Dr. Greg Rhee (University of Connecticut and Yale University School of Medicine) join AJP Audio to discuss estimating national trends in suicidal ideation and attempts in high school students with and without accompanying high-risk behaviors.  Afterwards, AJP Editor-in-Chief Dr. Ned Kalin discusses the rest of the July issue of the Journal. 00:07   Bommersbach and Rhee interview 00:36   Trends in suicide among high school students in the US 02:49   Variation in rates based on gender, racial identity, and sexuality 03:50   Did the rates increase during the COVID-19 pandemic? 04:14   Lessons to be learned from COVID? 05:23   Behavior risk factors 06:33   Clinical implications 08:19   Inflections in risk factors due to the pandemic? 08:52   Limitations 09:32   Future research 10:16   Kalin interview 10:31   Bommersbach et al. 14:20   Müller et al. 18:54   Ahn et al. 21:47   McCabe et al. Be sure to let your colleagues know about the podcast, and please rate and review it on Apple Podcasts, Google Podcasts, Spotify, or wherever you listen to it. Subscribe to the podcast here. Listen to other podcasts produced by the American Psychiatric Association. Browse articles online. How authors may submit their work. Follow the journals of APA Publishing on Twitter. E-mail us at [email protected]

Dr. Roy Perlis (Mass General Bringham, Boston) joins AJP Audio to discuss a machine learning model to examine electronic health records in individuals who had recently given birth designed to detect those who might develop postpartum depression.  Afterwards, AJP Editor-in-Chief Dr. Ned Kalin puts the rest of the June issue into context. 00:31     Perlis interview 02:56     Lack of validation in screening methods 04:03     Stumbling blocks on the road to validation 05:10     Synergy between screening scores and machine learning models 06:36     Issues with clinician adoption? 08:44     Administrative burden for running these models 10:38     Current clinical application 12:37     Screening without those with a history of depression 13:48     Limitations 15:30     Future research 17:26     Kalin interview 17:41     Clapp et al. 21:41     Kępińska et al. 25:19     Savitz et al. 25:25     Miller 28:38     Wall et al. Transcript Be sure to let your colleagues know about the podcast, and please rate and review it on Apple Podcasts, Google Podcasts, Spotify, or wherever you listen to it. Subscribe to the podcast here. Listen to other podcasts produced by the American Psychiatric Association. Browse articles online. How authors may submit their work. Follow the journals of APA Publishing on Twitter. E-mail us at [email protected]

Dr. Kenneth Ruggiero (Medical University of South Carolina, Charleston) joins AJP Audio to discuss the the effectiveness of an app-based intervention at reducing the symptoms of sleeplessness and posttraumatic stress in a broad cohort in the wake of a natural disaster.  Afterwards, AJP Editor-in-Chief Dr. Ned Kalin puts the rest of the May issue into context. 00:38     Ruggiero interview 03:13     Bounce Back Now app 05:03     Natural disasters and other sources of trauma 07:31     Low cost and broad-based intervention 08:49     Limitations 10:19     Changes in how the intervention was designed 11:17     Uptake and interactions with the app 13:15     Future directions 14:36     Kalin interview 14:50     Ruggiero et al. 19:26     Norman et al. 23:29     Conrod et al. 27:53     Olfson et al. 31:44     Olfson et al. Transcript Be sure to let your colleagues know about the podcast, and please rate and review it on Apple Podcasts, Google Podcasts, Spotify, or wherever you listen to it. Subscribe to the podcast here. Listen to other podcasts produced by the American Psychiatric Association. Browse articles online. How authors may submit their work. Follow the journals of APA Publishing on Twitter. E-mail us at [email protected]

Dr. Valentina Mancini (Oxford University) joins AJP Audio to discuss the impact of anticholinergic burden on cognition in patients with schizophrenia.  Afterwards, AJP Editor-in-Chief Dr. Ned Kalin puts the rest of the March issue into context. 00:32     Mancini interview 02:26     Anticholinergic burden method of action 02:58     Balancing the impact of side effects in schizophrenia treatment 04:52     Limitations 05:34     The need for further studies 05:59     Clinical implications 06:32     Further research 07:01     Trials needed 07:54     Kalin interview 08:03     Mancini et al. 11:23     Tiihonen et al. 13:43     Zhou et al. 16:28     Omlor et al. 18:51     Orhan et al. Transcript Be sure to let your colleagues know about the podcast, and please rate and review it on Apple Podcasts, Google Podcasts, Spotify, or wherever you listen to it. Subscribe to the podcast here. Listen to other podcasts produced by the American Psychiatric Association. Browse articles online. How authors may submit their work. Follow the journals of APA Publishing on Twitter. E-mail us at [email protected]

Dr. William Horan (Bristol Myers Squibb) joins AJP Audio to discuss a newly approved, novel treatment for schizophrenia spectrum disorder, which has potential impacts for cognition in patients.  Afterwards, AJP Editor-in-Chief Dr. Ned Kalin puts the rest of the March issue into context. 00:45     Horan interview 03:15     Novel mechanism of action in the treatment of schizophrenia 05:39     Side effect profiles 07:20     Clinical impacts 08:31     The need for further investigation 09:58     Limitations 11:05     Further research 13:08     Kalin interview 13:21     Horan et al. 17:34     Levenstein et al. 19:00     Fountoulakis et al. 20:57     Couture et al. 23:18     Stern et al. 27:35     McGirr et al. Transcript Be sure to let your colleagues know about the podcast, and please rate and review it on Apple Podcasts, Google Podcasts, Spotify, or wherever you listen to it. Subscribe to the podcast here. Listen to other podcasts produced by the American Psychiatric Association. Browse articles online. How authors may submit their work. Follow the journals of APA Publishing on Twitter. E-mail us at [email protected]

Dr. Andrea King (University of Chicago Medicine) joins AJP Audio to discuss a novel, real time assessment of the reward, stimulation, and negative affect of alcohol use in people with alcohol use disorder with and without depressive disorders.  Afterwards, AJP Editor-in-Chief Dr. Ned Kalin discusses the rest of the February issue, which focuses closely on issues surrounding addiction. 00:35     King interview 00:45     Allostatic model of addiction 02:12     Gathering data and the groups studied 07:37     The ethics of studying alcohol use in patients with AUD 10:38     Findings 13:29     The impacts of alcohol's pleasurable effects on people with AUD and those without 14:32     Limitations of natural environment research versus laboratory research 18:18     Clinical implications 20:09     Further research 22:56     Kalin interview 23:03     King et al. 26:21     Brand et al. 28:12     Conway et al. 32:17     Kypriotakis et al. 35:42     Kuhn et al. 39:37     Grilo et al. Transcript Be sure to let your colleagues know about the podcast, and please rate and review it on Apple Podcasts, Google Podcasts, Spotify, or wherever you listen to it. Subscribe to the podcast here. Listen to other podcasts produced by the American Psychiatric Association. Browse articles online. How authors may submit their work. Follow the journals of APA Publishing on Twitter. E-mail us at [email protected]

Dr. Charles Nemeroff (University of Texas at Austin) joins AJP Editor-in-Chief Dr. Ned Kalin to discuss the January issue of the American Journal of Psychiatry. Dr. Nemeroff is a guest editor of the special issue, which takes a close look at the potential, pitfalls, and clinicial implications of psychedelics in mental health treatment. 00:38     Nemeroff interview 02:27     McIntyre et al. 04:06     Ramaekers et al. 05:44     Ghaznavi et al. 08:01     Fonzo et al. 09:17     Wolfgang et al. 10:45     Psychedelics and psychotherapies 12:31     Aaronson et al. 14:17     Pagni et al. 15:31     Kirlić et al. 17:06     Olson Transcript Be sure to let your colleagues know about the podcast, and please rate and review it on Apple Podcasts, Google Podcasts, Spotify, or wherever you listen to it. Subscribe to the podcast here. Listen to other podcasts produced by the American Psychiatric Association. Browse articles online. How authors may submit their work. Follow the journals of APA Publishing on Twitter. E-mail us at [email protected]