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Dr. Charles Conway (Washington University School of Medicine, St. Louis) joins the podcast to discuss the RECOVER trial, a RCT that looked at vagus nerve stimulation and its effects on profoundly treatment resistant depression.  Following that, AJP Editor-in-Chief Dr. Ned Kalin is joined by the October issue guest editor, Dr. William McDonald (Emory University, Atlanta) to discuss the rest of the October issue, which focuses on neuromodulation and precision therapeutics. 00:42     Conway interview 02:34     Quality of life 05:13     Ethical considerations of a sham arm in this population 07:00     Timing and VNS treatment 08:03     Clinical implications 09:02     Limitations 10:12     Further research 11:30     McDonald and Kalin interview 13:50     Song et al. 14:08     Li et al. 15:44     Donnery et al. 16:38     Valiengo et al. 17:28     Rush 20:03     Mahmoudi 22:37     Conway et al. Transcript Be sure to let your colleagues know about the podcast, and please rate and review it on Apple Podcasts, Google Podcasts, Spotify, or wherever you listen to it. Subscribe to the podcast here. Listen to other podcasts produced by the American Psychiatric Association. Browse articles online. How authors may submit their work. Follow the journals of APA Publishing on Twitter. E-mail us at [email protected]

Dr. Heon-Jeong Lee (Korea University, Seoul) joins AJP Audio to discuss an app-based intervention designed to help individuals with mood disorders regulate their circadian rhythms to prevent recurrence of mood episodes.  Afterwards, Dr. Ned Kalin will join us again to discuss the rest of the September issue of the Journal, which takes a close look at clinical treatment. 00:44     Findings 01:42     How the app works 03:05     Differences between the app and traditional lifestyle advice 04:14     Ethics surrounding shame treatment arms 05:43     Broader applicability of the intervention 06:50     Limitations 08:19     Immediate clinical implications 09:33     Further research 10:08     Kalin interview 10:27     Yeom et al. 16:02     Schacht et al. 20:31     Khosravani et al. 24:52     Peterson et al. Transcript Be sure to let your colleagues know about the podcast, and please rate and review it on Apple Podcasts, Google Podcasts, Spotify, or wherever you listen to it. Subscribe to the podcast here. Listen to other podcasts produced by the American Psychiatric Association. Browse articles online. How authors may submit their work. Follow the journals of APA Publishing on Twitter. E-mail us at [email protected]

Dr. Deepak Cyril D'Souza (Yale University School of Medicine) joins the podcast to discuss a study looking at two cohorts of patients hospitalized with first instances of psychosis, one with cannabis exposure and one without. Afterwards, AJP Editor-in-Chief Dr. Ned Kalin takes us through the August issue of the Journal, which takes a look at issues surrounding schizophrenia spectrum disorder, from the clinical to basic science. 00:40     D'Souza interview 02:38     Subtyping and schizophrenia spectrum disorder 04:19     Relapse and long-term implications for cannabis induced psychosis 05:43     Improvements in cognition 08:03     Differences between the groups 09:26     Greater access and greater potency of cannabis products 11:29     Further research 13:45     Kalin interview 13:59     D'Souza et al. 21:34     Forsyth et al. 27:36     Enwright et al. Transcript Be sure to let your colleagues know about the podcast, and please rate and review it on Apple Podcasts, Google Podcasts, Spotify, or wherever you listen to it. Subscribe to the podcast here. Listen to other podcasts produced by the American Psychiatric Association. Browse articles online. How authors may submit their work. Follow the journals of APA Publishing on Twitter. E-mail us at [email protected]

Dr. Dilip Jeste (Social Determinants of Health Network, La Jolla, CA) joins the podcast to discuss how social determinants of health interact with treatment for psychiatric disorders.  Afterwards, AJP Editor-in-Chief Dr. Ned Kalin once again puts the rest of the July issue into context. 00:31     Impacts of social determinants of health on psychiatric disorders, research, and clinical care 04:43     Health related social needs versus social determinants of health 08:47     Loneliness as a risk factor 12:36     A clinician's role in societal factors 14:47     Mechanistic understandings social determinants and the exposome 18:17     Further research 22:25     Kalin interview 22:30     Jeste and Gyan 23:33     Blundell et al. 28:03     Yang et al. 32:20     Van der Meer et al. Transcript Be sure to let your colleagues know about the podcast, and please rate and review it on Apple Podcasts, Google Podcasts, Spotify, or wherever you listen to it. Subscribe to the podcast here. Listen to other podcasts produced by the American Psychiatric Association. Browse articles online. How authors may submit their work. Follow the journals of APA Publishing on Twitter. E-mail us at [email protected]

Dr. Jason Tucciarone and Dr. Alan Schatzberg (Stanford University, Stanford, CA) join AJP Audio to discuss the use of low-dose buprenorphine as an adjunctive therapy to extend the anti-suicidal effects of ketamine treatment in patients with major depressive disorder and suicidal ideation.  AJP Editor-in-Chief Dr. Ned Kalin joins to discuss the rest of the June issue of the Journal, which takes a close look at issues surrounding suicide and severe depression. 01:20     Tucciarone and Schatzberg interview 03:36     Disparity between effects on suicidal ideation and antidepressant ratings 05:36     Ethics of placebo and ketamine in patients with suicidal ideation 08:28     Immediate clinical implications 11:40     Limitations 14:10     Further research 16:19     Kalin interview 16:24     Tucciarone et al. 20:39     Rovers et al. 24:30     Jelen et al. Transcript Board-certified psychiatrists, if you're seeking meaningful inpatient work with real clinical autonomy, consider becoming the Clinical Director for a 16-bed behavioral health hospital in Fergus Falls or Bemidji, Minnesota. You'll lead a supportive interdisciplinary team, enjoy predictable work-life balance, and have opportunities for teaching and mentorship without RVU pressure or third-party billing. Learn more on APA's Career Center, JobCentral, by searching Direct Care and Treatment – State of Minnesota. Direct Care and Treatment – State of Minnesota:  bit.ly/DCTClinicalDirector Be sure to let your colleagues know about the podcast, and please rate and review it on Apple Podcasts, Google Podcasts, Spotify, or wherever you listen to it. Subscribe to the podcast here. Listen to other podcasts produced by the American Psychiatric Association. Browse articles online. How authors may submit their work. Follow the journals of APA Publishing on Twitter. E-mail us at [email protected]

In this special episode of AJP Audio, AJP Editor-in-Chief Dr. Ned Kalin is joined by Dr. María Oquendo (Perelman School of Medicine at the University of Pennsylvania, Philadelphia), chair of APA's Future DSM Strategic Committee to discuss a series of commentaries published in the May issue of the Journal discussing the strategic vision for the future of DSM. 00:39   Oquendo interview 03:07   Size of the response 04:18   Feedback 06:04   Incorporating the feedback 07:57   Emphasizing science with a title change for DSM 10:18   A living document 12:35   Changes from previous versions of DSM 16:08   Changes in documentation and coding 18:51   Lived experience 20:02   Working with AJP Links to the commentaries:  Initial Strategy for the Future of DSM María A. Oquendo, M.D., Ph.D., et al. The Future of DSM: A Report From the Structure and Dimensions Subcommittee Dost Öngür, M.D., Ph.D., et al. The Future of DSM: Are Functioning and Quality of Life Essential Elements of a Complete Psychiatric Diagnosis? Karen Drexler, M.D., et al. The Future of DSM: Role of Candidate Biomarkers and Biological Factors Bruce Cuthbert, Ph.D., et al. The Future of DSM: A Strategic Vision for Incorporating Socioeconomic, Cultural, and Environmental Determinants and Intersectionality Milton L. Wainberg, M.D., et al. Transcript Be sure to let your colleagues know about the podcast, and please rate and review it on Apple Podcasts, Google Podcasts, Spotify, or wherever you listen to it. Subscribe to the podcast here. Listen to other podcasts produced by the American Psychiatric Association. Browse articles online. How authors may submit their work. Follow the journals of APA Publishing on Twitter. E-mail us at [email protected]

Dr. Eduardo Butelman (Icahn School of Medicine at Mount Sinai, New York) joins AJP Audio to discuss the varying incidence of psychiatric comorbidities across patients diagnosed with substance use disorders.  Afterwards, AJP Editor-in-Chief Dr. Ned Kalin joins the podcast to discuss the rest of the May issue, which includes a discussion on the future of the DSM. 00:53     Butelman interview 02:23     Mechanisms of difference between males and females 04:04     Patterns of response between males and females in substance use disorders 05:54     Implications for research into sex-based differences 07:33     Racial and ethnic variations in findings 09:30     Limitations 10:46     Immediate clinical implications? 12:09     Further research 13:18     Kalin interview 13:38     Butelman et al. 17:11     Hinojosa et al. 22:49     van Rooij et al. 26:06     The future of DSM Transcript Be sure to let your colleagues know about the podcast, and please rate and review it on Apple Podcasts, Google Podcasts, Spotify, or wherever you listen to it. Subscribe to the podcast here. Listen to other podcasts produced by the American Psychiatric Association. Browse articles online. How authors may submit their work. Follow the journals of APA Publishing on Twitter. E-mail us at [email protected]

Yang Lu, M.S., and Catharine E. Fairbairn, Ph.D. (University of Illinois, Urbana-Champaign) join AJP Audio to discuss the longitudinal effects of the use of personal alcohol breathalyzers in a natural setting on alcohol usage. Afterwards, AJP Editor-in-Chief Dr. Ned Kalin joins the podcast to discuss the rest of the April issue, which focuses on subjects related to substance use disorders. 00:57     What did you discover about the long term effects of using a personal blood alcohol monitor? 03:12     Do health monitoring devices actually change behaviors? 04:10     What did your cohort look like? 08:49     Disparate impact of monitoring on heavy drinkers and light drinkers 11:36     Clinical implications 14:34     Limitations 15:46     Avenues for further research 18:39     Kalin interview 18:46     Lu et al. 24:00     Wittekind et al. 29:50     Nicholson et al. Transcript Be sure to let your colleagues know about the podcast, and please rate and review it on Apple Podcasts, Google Podcasts, Spotify, or wherever you listen to it. Subscribe to the podcast here. Listen to other podcasts produced by the American Psychiatric Association. Browse articles online. How authors may submit their work. Follow the journals of APA Publishing on Twitter. E-mail us at [email protected]

Chelsea Dyan Gober Dykan, M.A. (Tel Aviv University, Israel), joins AJP Audio to discuss a study looking at two versions of attention bias modification with an eye towards a prophylactic impact on developing PTSD in a cohort of combat-bound soldiers.  Afterwards, AJP Editor-in-Chief Dr. Ned Kalin joins the podcast to put the rest of the March issue into context. 00:57   Attention bias modifications 03:54   Response-time and gaze-contingent paradigms 05:05   Differences in efficacy between the two arms 08:06   Ethical considerations in investigating combat-bound soldiers 10:44   Controlling for combat experiences in studying PTSD 12:24   Duration of the effect 13:44   Limitations 15:03   Immediate clinical implications 16:22   Further research 17:05   Kalin interview 17:22   Dykan et al. 21:03   Kaul et al. 26:19   Kantrowitz et al. Transcript Be sure to let your colleagues know about the podcast, and please rate and review it on Apple Podcasts, Google Podcasts, Spotify, or wherever you listen to it. Subscribe to the podcast here. Listen to other podcasts produced by the American Psychiatric Association. Browse articles online. How authors may submit their work. Follow the journals of APA Publishing on Twitter. E-mail us at [email protected]

Dr. Ian Kelleher (University of Edinburgh, Scotland) joins AJP Audio to discuss an emulated target trial looking at the prophylactic qualities of doxycycline, an antibiotic, in an adolescent population at risk to develop schizophrenia spectrum disorder.  Afterwards, AJP Editor-in-Chief Dr. Ned Kalin joins the podcast to put the rest of the issue into context. 00:53   Doxycycline and the risk of developing schizophrenia 04:03   Emulated target trials versus randomized control trials 06:43   Methods of action 09:24   Dosage and exposure levels for doxycycline 10:15   Immediate clinical applications 10:56   Limitations of the study 11:33   Future research 12:43   Kalin interview 13:00   Lång et al. 19:43   Zhao et al. 25:20   Metrik et al. Transcript Be sure to let your colleagues know about the podcast, and please rate and review it on Apple Podcasts, Google Podcasts, Spotify, or wherever you listen to it. Subscribe to the podcast here. Listen to other podcasts produced by the American Psychiatric Association. Browse articles online. How authors may submit their work. Follow the journals of APA Publishing on Twitter. E-mail us at [email protected]

This special episode of AJP Audio brings together the editors of the American Journal Psychiatry and the AJP Residents' Journal to discuss important and impactful articles published in 2025. 00:39   Ned H. Kalin, M.D., discusses "Transcriptomic Analysis of the Human Habenula in Schizophrenia" by Ege A. Yalcinbas, Ph.D., et al. 06:23   Elisabeth Binder, M.D., Ph.D., discusses "Copy Number Variant Architecture of Child Psychopathology and Cognitive Development in the ABCD Study" by Zhiqiang Sha, Ph.D., et al. 11:17   Kathleen T. Brady, M.D., Ph.D., discusses "High-Potency Cannabis Use and Health: A Systematic Review of Observational and Experimental Studies" by Stephanie Lake, Ph.D., et al. 15:35   David A. Lewis, M.D., discusses "20 Years of Aberrant Salience in Psychosis: What Have We Learned?" by Philip R. Corlett, Ph.D., and Kurt M. Fraser, Ph.D. 17:27   William M. McDonald, M.D., discusses "Psychedelics for the Treatment of Psychiatric Disorders: Interpreting and Translating Available Evidence and Guidance for Future Research" by Roger S. McIntyre, M.D., F.R.C.P.C., et al. 24:04   Daniel S. Pine, M.D., discusses "Cognitive Behavioral Therapy and Lisdexamfetamine, Alone and Combined, for Binge-Eating Disorder With Obesity: A Randomized Controlled Trial" by Carlos M. Grilo, Ph.D., et al. 26:06   Carolyn Rodriguez, M.D., Ph.D., discusses "Randomized Controlled Trial of the Effects of High-Dose Ondansetron on Clinical Symptoms and Brain Connectivity in Obsessive-Compulsive and Tic Disorders" by Emily R. Stern, Ph.D., et al. 30:26   Sean T. Lynch, M.D., discusses "From Medical Practice to Mass Incarceration: A Historical Analysis of Racial and Ethnic Targeting in U.S. Drug Policy" by Rathisha Pathmathasan, D.O., et al. Transcript Be sure to let your colleagues know about the podcast, and please rate and review it on Apple Podcasts, Google Podcasts, Spotify, or wherever you listen to it. Subscribe to the podcast here. Listen to other podcasts produced by the American Psychiatric Association. Browse articles online. How authors may submit their work. Follow the journals of APA Publishing on Twitter. E-mail us at [email protected]

Dr. Julia Linke (University of Mainz, Germany) joins AJP Audio to discuss the use of neural efficiency, a measure of brain activity, as a potential biomarker in the treatment of children with anxiety disorder.  Afterwards, AJP Editor-in-Chief Dr. Ned Kalin joins the podcast to put the rest of the issue into context. 00:31   Linke interview 02:15   State or a trait? 04:15   Neural efficiency and CBT 05:22   Potential as a biomarker 07:08   Patient-rated and parent-rated measures of anxiety 08:16   Immediate clinical implications 09:50   Limitations 10:43   Future directions of research 11:44   Kalin interview 11:50   Linke et al. 15:16   Mallard et al. 18:11   Naples et al. 21:44   Mac Giollabhui et al. Transcript Be sure to let your colleagues know about the podcast, and please rate and review it on Apple Podcasts, Google Podcasts, Spotify, or wherever you listen to it. Subscribe to the podcast here. Listen to other podcasts produced by the American Psychiatric Association. Browse articles online. How authors may submit their work. Follow the journals of APA Publishing on Twitter. E-mail us at [email protected]

Dr. Suresh Durgam (Intra-Cellular Therapies, a Johnson & Johnson Company, Bedminster, NJ) joins AJP Audio to discuss a phase 3 randomized controlled trial looking at the use of the antipsychotic medication lumateperone as adjunctive to antidepressant therapy in the treatment of patients with major depressive disorder. Afterwards, AJP Editor-in-Chief Dr. Ned Kalin discusses the rest of the December issue of the Journal. 00:48   Durgam interview 03:09   Mechanism of action 04:44   Patient-reported outcomes 06:31   Immediate clinical implications 07:32   Limitations 08:08   Further research 09:25   Kalin interview 09:38   Durgam et al. 13:09   Lin et al. 17:22   Brodsky et al. Transcript Be sure to let your colleagues know about the podcast, and please rate and review it on Apple Podcasts, Google Podcasts, Spotify, or wherever you listen to it. Subscribe to the podcast here. Listen to other podcasts produced by the American Psychiatric Association. Browse articles online. How authors may submit their work. Follow the journals of APA Publishing on Twitter. E-mail us at [email protected]

Dr. Lara Coughlin (University of Michigan, Ann Arbor) joins AJP Audio to discuss a study looking the impact of contingency management on all cause mortality in patients with stimulant use disorder. Afterwards, AJP Editor-in-Chief Dr. Ned Kalin discusses the rest of the November issue of the Journal. 01:09   Coughlin interview 02:05   Stimulant use disorder and contingency management 04:37   Mortality 05:12   Contingency management and "moral hazard" 08:30   Clinical uptake of contingency management 09:28   Broader applicability to psychiatric conditions 10:31   Limitations 11:39   Further research 12:32   Kalin interview 12:49   Coughlin et al. 16:41   Yalcinbas et al. 22:22   Na et al. Transcript Be sure to let your colleagues know about the podcast, and please rate and review it on Apple Podcasts, Google Podcasts, Spotify, or wherever you listen to it. Subscribe to the podcast here. Listen to other podcasts produced by the American Psychiatric Association. Browse articles online. How authors may submit their work. Follow the journals of APA Publishing on Twitter. E-mail us at [email protected]

Dr. Shau-Ming Wei (National Institute of Mental Health, Bethesda, MD) joins AJP Audio to discuss a replication study looking at impact of hormone addback to a hormone suppression regimen for the treatment of premenstrual dysphoric disorder. Afterwards, AJP Editor-in-Chief Dr. Ned Kalin discusses the rest of the October issue of the Journal.  00:34   Wei interview 02:59   PMDD 04:22   Up and downsides of hormone suppression 05:52   Hormone addback 07:15   Limitations of the current study 08:38   Further research 10:42   Kalin interview 10:58   Wei et al. 15:25   Sanacora et al. 20:07   Whittle et al. 23:06   Cooper et al. Transcript Be sure to let your colleagues know about the podcast, and please rate and review it on Apple Podcasts, Google Podcasts, Spotify, or wherever you listen to it. Subscribe to the podcast here. Listen to other podcasts produced by the American Psychiatric Association. Browse articles online. How authors may submit their work. Follow the journals of APA Publishing on Twitter. E-mail us at [email protected]