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Are universities doing enough to help students learn from their mistakes, and allowing them to see setbacks as a spur to creativity and success? Materials scientist Mary Ryan, Vice-Provost (Research and Enterprise) at Imperial College London, argues that a good training in science should accommodate learning from setbacks, wrong moves and false starts. Too often, students judge themselves harshly by one poor exam result or failed experiment, she suggests. In April 2026 Ryan addressed Failure in Science, a conference held at Imperial in partnership with Nature. In the third episode of a six-part podcast series that revisits some of the conference themes, she says: “People often point to California’s Bay Area as being this hotbed of innovation. “You can very easily be a serial startup creator there. When you talk to entrepreneurs, one of the first things they tell you is the three companies that they had that failed. That doesn’t preclude them starting a new one and getting funding for it, whereas I think in the UK and probably in Europe in general, there’s more of a requirement for a track record. “We have to shift that dynamic if the rest of the world is going to catch up with what’s happening in the US.” Hosted on Acast. See acast.com/privacy for more information.

Melanie Stefan leads a computational neurobiology lab at MSB Medical School Berlin. But as a postdoc 16 years ago, a failed fellowship application prompted her to write an article in Nature. In it, she called for researchers to keep a ‘CV of failures.’ Stefan says: “The idea would be that the successful people in science would actually open up about the failures that they had on their way, and how many jobs they didn’t get, how many positions they weren’t admitted to, how many grants they failed to receive, how many papers were rejected, things like that, so that younger scientists (like I was at the time) could actually take heart and see that this is actually a normal part of the process and that they’re not alone. “So that was the idea. And since then, I’ve kind of become the poster child of failure a little bit.” This is the second episode of a six-part podcast series about failure in science, pegged to a conference held in April at Imperial College London, in partnership with Nature. Hosted on Acast. See acast.com/privacy for more information.

Experiments fail and careers plans can go awry, forcing us to pivot in a different direction. Organizations also make mistakes. But failure, at both an individual and institutional level, can be a useful teacher. In the first episode of a six-part podcast series about failure in science, Nature editor-in-chief Magdalena Skipper says: “I find it surprising that we don’t talk more about failure, that we’re not more honest about the role that it plays. Nobody wants to talk about it. Hence, it’s a taboo.” In April, the journal partnered with Imperial College London on a one-day conference looking at the role of failure in science. Some of the themes from that event will be covered in future episodes, including how Silicon Valley celebrates ​​​​​​​“failing fast” as an important learning tool which academia can learn from, and the importance of risk-taking in research. Launching the conference alongside Stephen Webster, who leads Imperial's Good Science project, a programme that examines research culture, Skipper said the best career decision she ever made was stepping away from active research. She tells the podcast: “To some who are wedded to the idea that the only true path for a researcher is to continue in active research, that was a sign of my failure. I failed to be a successful academic researcher.” She ends by quoting British statesman Sir Winston Churchill, who said: “Success is the ability to go from one failure to another with no loss of enthusiasm.” Hosted on Acast. See acast.com/privacy for more information.

Theoretical physicist Stephon Alexander was 12 years old when his father bought him a saxophone at a garage sale near their home in the Bronx, New York. Soon after he heard Ornette Coleman, a pioneer of free jazz, on the radio. “There was this saxophone playing that was completely out there, completely wild,” he recalls. “You could just play whatever you want and make up whatever you want.”   Alexander, a jazz saxophonist who now directs the Brown University Center for Theoretical Physics and Innovation, in Providence, Rhode Island, says: “I would not be the physicist I am today if weren't for my practice as a musician, especially as an improvisational musician.” He credits it for making him “more fluid and flexible mentally in terms of approaching and attacking physics problems,” some of which he ponders while watching performances in New York jazz clubs.   In the final episode of Creativity in Science, a six-part podcast series, Alexander also lists his former high school physics teacher Daniel Kaplan as a key influence. He says that Kaplan, a professionally-trained jazz musician, taught him that “intuition is the lifeblood of a good physicist.” Hosted on Acast. See acast.com/privacy for more information.

Frances Brodsky believes that writing her three mystery novels set in the world of bench science has improved her scientific writing. “I love making up titles for my books and chapters,” she says. “One of the best ways to train someone in the lab to focus on their project is for them to come up with the title of a paper that they want to write. That tells them where they're going. Also, when I interview people, I ask them: ‘What is the title of the thesis you plan to write?’​​​​​​​” Brodsky, a cell biologist at University College London, writes under the pseudonym B. B. Jordan. Her books feature Celeste Braun, a virologist in San Francisco, California, who uses her scientific expertise to solve mysteries and fight crime. “Sitting down to write these novels, my scientific writing became markedly better,” she says. “The exercise of fiction writing helped me put my work into a narrative.​​​​​​​” In the penultimate episode of this six-part podcast series on creativity in science, Brodsky says the discipline of writing a novel has also taught her perseverance, adding: “When you start a writing project, you have to stick with it to get it to the end. Sticking with something and having faith that it will work out is a really good quality to have.​​​​​​​” Hosted on Acast. See acast.com/privacy for more information.

Brandon Brown “fell into farming” after tiring of city life during the COVID-19 pandemic and now tends more than 150 fruit trees alongside his research into HIV and public health ethics at the University of California, Riverside School of Medicine. “I had to look at farming the same way that I look at my academic career, and to take it one day at a time with my eyes towards a goal,” he says. Brown says it took him a while for the realization to dawn. “My PhD taught me that the work is never done, and there’s always a new research project to pursue, more students to collaborate with, more policies to work on,” he says. “And since research builds on research, the fun never ends.” Mornings spent outdoors also gives him time to think about work priorities. “I have lots of free time to think as I do the farming, and many times I write down notes as I’m working, because ideas and kind of reminders and goals and deadlines pass through my mind,” he says. There are other benefits. Brown says he now falls asleep to the “beautiful” sound of howling coyotes, alongside possums, racoons, skunks, squirrels, lizards and gophers. This is the fourth episode in a six-part series about creativity in science. Previous episodes featured a researcher who draws parallels between her research and sewing, another whose pursuit of baking and fermentation revealed fresh career opportunities, and two researchers who follow the concept of “day and night science” to distinguish between routine tasks and reflection. Hosted on Acast. See acast.com/privacy for more information.

Baking bread during Covid-19 lockdowns provided Chantle Edillor with some career inspiration. “I knew I wanted to do something different and an exploration in sourdough presented an opportunity that I felt uniquely able to pursue,” she says.  In 2022, after completing PhD research into metabolic diseases at the University of California Los Angeles, Edillor began a postdoc there, where she researched the anti-inflammatory properties of fermented foods.  She now works as a fermented food scientist at Microcosm Foods, a non-profit research organization that maps connections between fermented foods, microbes and human health, a role she combines with assay development at the Astera Institute, a similar non-profit based in the Bay Area, San Francisco.   In the third episode of a six-part podcast series about creativity in science, Edillor says fermentation techniques re-ignited a childhood interest in cooking: “I have early memories of sitting and watching the Food Network with a metal bowl full of egg whites in my lap, holding a whisk and attempting to make stiff peak meringue, but also to understand how proteins capture air to create volume and texture.”  Edillor’s culinary and scientific creativity extends to adding kombucha to leftover dinner party wine to make red wine vinegar, and making miso from blue tortillla chips. “Because the chips had been deep fried and fat does not necessarily ferment super well, it had this off flavour, kind of oxidized fat. I​​​​​​​’ll not be commercializing that anytime soon.” Summing up her career to date, she says: “I​​​​​​​’m a human geneticist masquerading as a yeast geneticist, masquerading as a microbiologist. There are certain areas of science that are less competitive and more collaborative. Those are the spaces I like to occupy.” Hosted on Acast. See acast.com/privacy for more information.

Yasmin Proctor-Kent likens sewing to science. “I find them really hard to separate them in my brain. I don’t think I can sew without engaging the same part of my brain that I do science with,” she says.   For Proctor-Kent, a research and development scientist at the cancer diagnostics company Leica Biosystems, based in Melbourne, Australia, the two pursuits require similar approaches, relying on her own and others’ prior knowledge and expertise, reading papers, or reading from other people who have sewn a similar garment. “It’s about applying theoretical knowledge to something tactile, something practical that you’re doing,” she adds.   In the second episode of a six-part podcast series about creativity in science, Proctor-Kent recounts how she honed her sewing skills during the Covid-19 lockdown before applying to The Great British Sewing Bee, an annual TV competition, reaching the 2025 finals.   Kit, a semi-finalist and mathematician, was similarly creative. “Mathematics and spatial reasoning and 3D plotting and all of that mathematical brain that Kit has, really did apply to the Bee,” she says. “When we were given a sewing pattern and told to make it in two hours…Kit already knew exactly how every single pattern piece fit together.”   Finally, Proctor-Kent urges other scientists to take up a pastime, even if it feels risky. “You get to a point in your career where you have success…you have a fear of being bad, at trying something new. We should all sit in that fear. Allow ourselves to be wrong. Allow ourselves to be bad at stuff. Allow ourselves to be embarrassed.”   Hosted on Acast. See acast.com/privacy for more information.

The French biologist and Nobel prizewinner François Jacob talked about day and night science as part of the creative process that underpins research. The former, he argued in his 1988 autobiography, is a “cold, orderly logic” leading to a conclusion of the kind that gets covered in seminars and papers. Night science, in contrast, is a “stumbling, wandering exploration of the natural world.​​​​​​​” In the first episode of a six-part series about creativity in science, Itai Yanai and Martin Lercher describe how they apply the day/night science concept in their own research and collaborations. Yanai, who studies gene regulation and cellular plasticity at New York University Grossman School of Medicine, recalls telling his lab colleagues to change tack when they get stuck: “We need to snap out of this. We need to zoom out. We need to pop out into the world of night science, into the world of ideas, where we’re going to have to use abstract thinking. We’re going to use every trick we got, And that’s going to give us the way forward.” Yanai and Lercher, a computational cell biologist at Heinrich Heine University in Düsseldorf, Germany, co-host the Night Science podcast and run workshops outlining the tools required to make science more creative alongside the “executive” process such as running experiments, applying for grants and writing papers. The two compare performers that pivot between musical genres (Bob Dylan from folk to rock, for example, and Beyoncé from R&B to country) to scientists who change disciplines, bringing the fresh thinking of a “beginner’s mind” to a particular challenge. “You hold no allegiance, no loyalty to any particular idea. Everything is on the table,” concludes Yanai. Future episodes will explore different approaches to cultivating creativity in science. Hosted on Acast. See acast.com/privacy for more information.

Among the barriers faced by researchers who move abroad to develop their careers is a so-called “hidden curriculum,” says Sonali Majumdar, whose book, Thriving as an International Scientist, was published last year. Navigating these unwritten rules that cover social norms and cultural expectations, both in the lab and outside work, can feel particularly daunting to scientists who, like her, were born elsewhere, she adds.  In addition, international scientists often have restrictive funding arrangements that tie them to a particular lab or Principal Investigator’s research focus, she says. US visa restrictions can often mean missing family events back home. Majumdar, for example, who gained a biochemistry and molecular biology PhD from the University of Georgia in Athena in 2014, could not return to India to attend her parents’ funerals. “It was probably the biggest sacrifice I’ve had to make in my life,” she says.   In the final episode of a six-part podcast series covering books about the scientific workplace, Majumdar, who is now assistant Dean for professional development at Princeton University in New Jersey, tells Holly Newson that having a “growth mindset” can help international scientists to thrive abroad.   This means not focusing on problems, but on possibilities and solutions, she says, supported by advisors, mentors, and sponsors.  The US, she says, has a reputation as a melting pot of different cultures, a place to meet colleagues with a shared passion for science and solving problems.  But in the last decade the climate for researchers who relocate there from abroad has become more difficult, she adds.  Hosted on Acast. See acast.com/privacy for more information.

Simon May describes his 2025 book Jump! as a new approach to conquering procrastination. Unlike self-help manuals that urge readers to break tasks down into manageable chunks with clear deadlines, May digs into the philosophy of why we put things off. He also explores not only why we fear career failure but also (more mysteriously, he says) career success, and why boredom and regrets are a “phenomenal wake-up call” to be learnt from.  The modern cult of work, May tells Holly Newson in the penultimate episode of this podcast series about books covering the scientific workplace, forces us onto a productivity treadmill that can sap our motivation.  “If something becomes cold and alienating and simply production-oriented, it ceases to engage,” he says, highlighting some scenarios: “I need to get this out by Monday morning. My competitor in the next lab has produced three papers this year, and I’ve only produced one.”  But how do you make an important personal or professional goal less important, less intimidating, and so more achievable?  May, a visiting professor of philosophy at Kings College London, offers some strategies. This includes how he conquers his own procrastination as a book deadline looms, describing himself as someone who feels “paralyzed” by the importance of the project.  May concludes with a warning about the “mirage of fulfilment”  felt by the 19th century Russian author Leo Tolstoy. Aged 50 and at the height of his fame, Tolstoy felt his life was meaningless. “One other thing to avoid is this sense that the destination is the key, that, once reached, will provide a sense of lasting fulfillment.” Instead, he argues, it’s the journey that counts.  Hosted on Acast. See acast.com/privacy for more information.

Joseph Jebelli believes burnout and overwork has reached pandemic levels, telling Holly Newson that it kills 750,000 people annually, with three out of five workers struggling to maintain a healthy work-life balance.   His 2025 book, The Brain At Rest, proposes that regular bouts of doing nothing can change your life. Finding time to let your mind wander and take a daily 30-minute nap can make you more creative and efficient, he argues.   In the fourth episode of a six-part podcast series focused on books about the scientific workplace, Jebelli describes the "productivity guilt" he felt during his neuroscience PhD at University College London, where he studied the cell biology of neurodegenerative diseases, followed by a postdoc at the University of Washington, Seattle. "It's the guilt in which you equate your worth as a human being with your output, with how many hours you're in the lab. If it were up to me, there would be a napping room in all laboratories. We have to get it out of our heads that we’re switching off, shirking, or being irresponsible or reckless. We’re actually helping our brains produce our best work.” Hosted on Acast. See acast.com/privacy for more information.

Gertrude Nonterah helps researchers step off the academic hamster wheel and seek opportunities beyond their specialty. She does this by tapping into her personal experiences of losing a postdoctoral position when her lab leader’s funding ran out, followed by a role at a biotechnology company that ended after two months.   Nonterah now works in medical communications and career counselling through The Bold PhD, a consultancy she set up in 2021, and a podcast, which she launched last year. Her 2025 book, Navigating the Pivot, promises strategies and insights to power career transitions from academia.   In the third episode of a podcast series focused on books about the scientific workplace, Nonterah, who is based in San Diego, California, tells Holly Newson how to tailor a CV or resume for industry employers. Instead of focusing on publications, she urges industry job applicants to show evidence of problem-solving, a highly-prized skill in the sector. Another thing to include are examples of communicating their research to people beyond their academic specialty. Nonterah then emphasizes the importance of networking, describes strategies to counter imposter syndrome, and offers advice on how to talk about career setbacks. Finally, she talks about how to bounce back from being laid-off, based on her own experience. She tells Newson: “How do I turn this into my comeback? How do I turn this into a time where I rediscover myself, my skills, when I rebrand and reinvent myself.”  Hosted on Acast. See acast.com/privacy for more information.

Learning to care less about how you come across in a conference talk, funding pitch or networking event frees you to communicate more naturally and confidently, says Susie Ashfield. In the second episode of a podcast series focused on six books about the scientific workplace, Ashfield, whose 2025 book, Just F**king Say It, includes real-life case studies of both good and bad communication, says scientist interviewees are often burdened by the “curse of knowledge.” This means they include too much detail instead of focusing on telling a simple story with a beginning, a middle and an end. Ashfield, an actor-turned-communications coach based in London, tells Holly Newson that presenters often fail to rehearse a science conference talk sufficiently. They also default to listing their academic achievements rather than focusing on the messages that their audience needs to hear. In the case of an investor pitch, this could mean focusing on a technology’s potential to save lives, not a detailed description of the underlying science, she argues. She also offers advice on how to approach networking, including tips on how to introduce yourself, keep conversations flowing, and how to politely move on to speak with other attendees. Finally, she offers advice on how to say no, handle difficult supervisors and pay negotiations. Explaining why she named her book Just F**king Say It, and why people should care less about how they come across, she tells Newson: “We are all desperately, concerned about what other people think of us. When we overthink how we walk into a room, we put levels of pressure on ourselves that just shouldn’t be there. The ethos is to just care less. Let it go. See what happens. Enjoy it.” Hosted on Acast. See acast.com/privacy for more information.

In the first episode of a podcast series focused on six books about the scientific workplace, Cordelia Fine tells Holly Newson why she wrote Patriarchy, Inc: What we Get Wrong About Gender Equality and Why Men Still Win at Work. Fine, a psychologist and workplace gender-equity researcher at the University of Melbourne, Australia, offers a blueprint for a fairer society that does not single out women as “a problem to be fixed.​​​​​” Describing the gender pay gap as largely a “motherhood pay gap,” she outlines how employers can support staff who return to work after a career break, without fostering resentment among colleagues. She also explains why many workplace diversity, equity and inclusion (DEI) initiatives, including unconscious bias training, are ineffective and can sometimes be offensive to the groups they aim to support. Fine also draws on historical examples of women being pushed out when men enter professions in larger numbers, and the effect this can have on the workplace culture. Hosted on Acast. See acast.com/privacy for more information.