Advertise on podcast: The Human Upgrade: Biohacking for Longevity & Performance

The Neuroscience of Flow, Peak Performance, Psychedelics, Trauma, Intuition & Consciousness with Steven Kotler Host Dave Asprey sits down with Steven Kotler, New York Times bestselling author and leading researcher in the neuroscience of flow, to explore how altered states of consciousness influence peak performance, mental health, creativity, intuition, and our perception of reality. Steven Kotler is a bestselling author of 17 books, including The Art of Impossible and We Are as Gods, and the founder of the Flow Research Collective. For decades, he has studied the neurobiology of peak performance, working with elite athletes, military personnel, and high-performing professionals to understand how people can reliably access flow states. Dave and Steven begin by exploring the neuroscience of flow and why it may be one of the most powerful altered states available without drugs. Steven explains how dopamine, norepinephrine, serotonin, anandamide, and endorphins contribute to the flow experience, why his research suggests caffeine can increase flow susceptibility, and how chasing the neurochemical high of peak performance can become dangerous. They discuss the darker side of flow training, including its potential risks for people prone to mania, the importance of recovery, and why attempting to remain in a flow state indefinitely can undermine performance. Steven shares how his training programs approach sleep, attention, and behavioral changes to help people access flow more consistently. The conversation then moves into psychedelics, ketamine-assisted therapy, and the neuroscience of trauma. Steven introduces emerging research suggesting that unresolved emotional patterns may involve the brain's predictive processing systems. Dave shares a personal experience involving Joe Rogan and how revisiting an early childhood memory changed his emotional response to public criticism. Dave and Steven also explore how the brain constructs reality, including the neuroscience of perception, sensory processing, and the flexible boundary between ourselves and our environment. They discuss how flow alters our sense of self, why the brain predicts what we experience before we consciously perceive it, and how these mechanisms may help explain certain spiritual and out-of-body experiences. Finally, Steven reveals new research investigating the neurological connections between flow, intuition, synchronicity, and purpose. He discusses emerging theories of consciousness, the role of information processing in subjective experience, and how artificial intelligence may change the future of human performance. You'll Learn: How flow states influence dopamine, norepinephrine, serotonin, anandamide, and endorphins, and why Steven's research suggests caffeine may help make the brain more susceptible to flow.Why chasing the neurochemical high of flow can become dangerous, how flow training may affect people prone to mania, and why sleep and recovery are essential for sustained peak performance.How ketamine-assisted therapy may help uncover forgotten emotional experiences and why Steven believes the brain's predictive processing systems play an important role in trauma.How the brain constructs our perception of reality, why sensory information reaches consciousness at different speeds, and what happens to our sense of self during altered states.Why flow may enhance intuition and how emerging neuroscience research is investigating connections between synchronicity, purpose, and the brain's information-processing systems.How Steven is using neuroscience, artificial intelligence, and years of flow training data to develop more accessible methods for improving focus, learning, and performance. Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: Steven Kotler, Dave Asprey, flow state, neuroscience of flow, peak performance, Flow Research Collective, dopamine, caffeine and flow, altered states, consciousness, psychedelics, ketamine therapy, trauma, predictive processing, neuroplasticity, intuition, synchronicity, brain science, mental performance, cognitive enhancement, flow triggers, serotonin, anandamide, meditation, human optimization, artificial intelligence, We Are as Gods, The Art of Impossible New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient.  Resources:  • Explore Steven Kotler's books, research, and flow training programs at https://www.flowresearchcollective.com/ • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/  • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.  • Danger Coffee: https://dangercoffee.com/discount/davetube  • My Daily Supplements: SuppGrade Labs (15% Off)  • Favorite Blue Light Blocking Glasses: TrueDark (15% Off)  Thank you to our sponsors!     ZenBud | Dave’s Nervous System Biohack. Visit zenbud.health and use code DAVE15 at checkout for a discount.  Timeline | Visit timeline.com/dave and get up to 20% off when you subscribe and saveOneSkin | For a limited time try the new OS-01 FACE RICH CREAM with 15% off at oneskin.co/DAVEKenetik | Instead of pushing your system harder, Kenetik feeds your brain the ketones it craves to fuel calm clarity and steady focus. Go to drinkkenetik.com/DAVE and use code DAVE for a discount. Timestamps:   00:00 — Trailer 01:12 — Intro 05:08 — Psychedelics and Peak Performance 11:10 — Trance, Voices, and Shamanism 18:00 — Dangers of Flow Training 24:00 — Ketamine and Innate Intelligence 30:00 — The Prediction Problem 35:25 — Embodied Cognition 46:30 — Consciousness and Synchronicity 50:20 — New Books and Research 53:00 — Flow for the Many See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

The Miracle Morning, Visualization, Affirmations, Meditation, Morning Routines, Productivity & the Psychology of Success with Hal Elrod Host Dave Asprey sits down with Hal Elrod, bestselling author of The Miracle Morning and personal development expert, to explore morning routines, visualization, affirmations, meditation, productivity, circadian rhythms, habit formation, and the psychology of success. Hal Elrod is the creator of The Miracle Morning, a bestselling book and personal development method that has helped millions improve their daily habits. After surviving a devastating car accident at age 20 and later battling life-threatening cancer, Hal developed a philosophy centered on resilience, personal responsibility, and consistent daily practices. Dave and Hal challenge the idea that success requires waking up at 5 AM. They discuss chronotypes, circadian biology, and why morning routines should work with your natural sleep patterns. Hal introduces his six-part SAVERS framework, explaining how meditation, affirmations, visualization, exercise, reading, and journaling can transform your morning in as little as six minutes. They explore how smartphones disrupt attention, why visualization works best when paired with mental rehearsal, and how these techniques can help overcome procrastination. Hal shares how he used visualization to train for a 52-mile ultramarathon, while Dave discusses advanced meditation, neurofeedback, and the role of emotional states in mental performance. The conversation also challenges traditional positive affirmations. Hal explains why unrealistic statements often fail and shares a three-step method for setting commitments, identifying motivations, and taking action. Dave connects these practices to consciousness, altered states, and the relationship between intention and human performance. Finally, Hal reflects on surviving cancer and a near-fatal car accident, sharing how his daily practices helped him build resilience. Dave and Hal discuss the balance between disciplined action, belief, and the mental states that influence our ability to achieve meaningful goals. This episode is essential listening for anyone interested in morning routines, visualization, affirmations, meditation, productivity, habit formation, circadian rhythms, overcoming procrastination, mental performance, emotional resilience, consciousness, and the science of personal development. You'll Learn: Why waking up at 5 AM isn't necessary for success and how to build a morning routine around your natural circadian rhythm and chronotypeHow Hal Elrod's six SAVERS practices can improve daily focus, discipline, and emotional well-being in as little as six minutesWhy checking your smartphone first thing in the morning can undermine attention, productivity, and your ability to respond intentionally throughout the dayHow to use visualization and detailed mental rehearsal to overcome procrastination, strengthen motivation, and follow through on difficult goalsWhy traditional positive affirmations often fail and how to create actionable affirmations based on specific commitments, meaningful reasons, and daily behaviorsHow meditation, emotional states, and intentional daily habits helped Hal navigate life-threatening health challenges and develop greater resilience Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living.  New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient.  Keywords: Hal Elrod, Dave Asprey, The Miracle Morning, Miracle Morning routine, SAVERS method, six minute morning routine, morning habits, 5 AM wake up, circadian rhythm, sleep chronotypes, visualization techniques, mental rehearsal, positive affirmations, actionable affirmations, meditation, morning meditation, overcoming procrastination, habit formation, productivity habits, goal setting, self discipline, emotional resilience, neurofeedback, altered states, consciousness, biohacking Resources:  • Explore Hal Elrod's Miracle Morning method, books, documentary, and app at https://miraclemorning.com/ • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/  • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.  • Danger Coffee: https://dangercoffee.com/discount/davetube  • My Daily Supplements: SuppGrade Labs (15% Off)  • Favorite Blue Light Blocking Glasses: TrueDark (15% Off)  Thank you to our sponsors!       -Butcher Box | Go to ButcherBox.com/HUMANUPGRADE to get $20 off your first box, plus your choice of free ground beef for life, or free chicken thigh -Timeline | Visit timeline.com/dave and get up to 20% off when you subscribe and save. -BodyHealth |Visit BodyHealth.com and use code DAVE20 for 20% off your first purchase. -Quantum Upgrade | Go to QuantumUpgrade.io/DAVE. to claim your 15-day free trial Timestamps:   00:00 — Trailer 01:30 — Intro & Miracle Morning 05:03 — The SAVERS Acronym 10:38 — Social Media & Smartphones 16:30 — Combining SAVERS & Visualization 22:08 — The Ultramarathon Story 28:24 — Affirmations & State 34:10 — Manifestation & Consciousness 37:26 — Near-Death & Miracles 42:30 — Perception & Brain Power See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Try TrueDark glasses: https://truedark.com Try Danger Coffee: https://dangercoffee.com/discount/davetube Try Suppgrade Labs: https://shopsuppgradelabs.com/ I slept 8 hours a night and got 5 minutes of deep sleep, and no doctor could help me. Then I found a molecule that hits the same receptor as Valium but WITHOUT sedating you. 400 mg before bed, stacked with four things that cost nothing, took me from 5 minutes to 90. Here's all five, plus WHY it’s mission critical you get this precious deep sleep (hint: it has to do with your memory as you age). Thank you to our sponsors! -ECHO Water | Go to http://echowater.com/dave and use code DAVE10 for 10% off your ECHO Flask. -Butcher Box | Go to ButcherBox.com/HUMANUPGRADE to get $20 off your first box, plus your choice of free ground beef for life, or free chicken thigh -Fatty15 | Go to fatty15.com/DAVE to get an additional 15% off their 90-day Starter Kit -iRestore | Unlock your best hair & skin with @iRestorelaser and HUGE savings on iRESTORE with code DAVE at irestore.com/DAVE Connect with Dave Asprey! Website: https://daveasprey.com TikTok: https://www.tiktok.com/@daveaspreyofficial Instagram: https://www.instagram.com/dave.asprey/ Facebook: https://www.facebook.com/Daveaspreyofficial/ X: https://x.com/daveasprey YouTube: https://www.youtube.com/c/daveaspreybpr The Human Upgrade Podcast: https://www.instagram.com/TheHumanUpgradePodcast/ https://m.facebook.com/Thehumanupgrade/ Danger Coffee: https://dangercoffee.com/discount/dave15? Dave Asprey’s BEYOND Conference: https://beyondconference.com/ Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/ Dave's favorite supplements: https://www.shopsuppgradelabs.com/discount/DAVE15 Join my Substack: https://substack.daveasprey.com Upgrade Labs: https://upgradelabs.com 40 Years of Zen: https://40yearsofzen.com See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

The king is back! You probably recognize his name as the author of the famous book, Men Are From Mars, Women Are From Venus.  But what's especially exciting is how John has evolved his insights to address the changing dynamics between men and women in the modern world, as he highlighted in his 2020 book, Beyond Mars and Venus: Relationship Skills for Today's Complex World. Now, why is this episode a must-listen? Well, John isn't just a relationship expert; he's also a seasoned biohacker who understands the profound impact of our environment – including relationships – on our hormones, happiness, and dopamine levels. In essence, he's been biohacking before it even had a name. With decades of wisdom, he offers invaluable insights into navigating the complexities of male-female relationships in today's world. Delve into the fundamental differences between men and women, the importance of appreciation in relationships, what truly motivates men, and practical tips on boosting testosterone and managing emotions. We also explore how men and women process feelings differently, the art of setting boundaries, and the language of love as the language of hormones. Get ready for a masterclass in understanding the dynamics of modern relationships and how to create lasting happiness. Timestamps: 00:00 — Intro 04:57 — Hormones Drive Relationships 08:29 — Emotional Manipulation & Control 20:42 — Detachment & The Cave 31:37 — Listening Without Losing It 39:49 — When Negativity Never Passes 46:54 — Fasting & Testosterone Science 01:04:23 — Languages of Love & Hormones 01:14:54 — Surviving Public Attacks 01:31:41 — Porn, Polarity & Reassurance 01:44:00 — Wrap-Up Thank You To Our Sponsors! Butcher Box | Go to ButcherBox.com/HUMANUPGRADE to get $20 off your first box, plus your choice of free ground beef for life, or free chicken thighThe One Device | Use code DAVE for $10 off at theonedevice.com/daveViome | Check it out at viome.com and use code 10DAVE for 10% off. It’s time to stop guessing and start knowing your body.iRestore | Unlock your best hair & skin with @iRestorelaser and HUGE savings on iRESTORE with code DAVE at irestore.com/DAVE Resources:  • Learn More About John’s Work At: https://www.marsvenus.com/ • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/  • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.  • Danger Coffee: https://dangercoffee.com/discount/davetube  • My Daily Supplements: SuppGrade Labs (15% Off)  • Favorite Blue Light Blocking Glasses: TrueDark (15% Off)  Timestamps: 00:00 — Intro 04:57 — Hormones Drive Relationships 08:29 — Emotional Manipulation & Control 20:42 — Detachment & The Cave 31:37 — Listening Without Losing It 39:49 — When Negativity Never Passes 46:54 — Fasting & Testosterone Science 01:04:23 — Languages of Love & Hormones 01:14:54 — Surviving Public Attacks 01:31:41 — Porn, Polarity & Reassurance 01:44:00 — Wrap-Up See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Sleep Anxiety, Insomnia, Circadian Rhythms, Chronotypes, Sleep Trackers & How to Sleep Better with Dr. Michael Breus  Host Dave Asprey sits down with Dr. Michael Breus, clinical psychologist, sleep specialist, and internationally recognized sleep expert known as The Sleep Doctor, to explore insomnia, sleep anxiety, circadian rhythms, chronotypes, nighttime awakenings, temperature regulation, sleep medications, wearable sleep trackers, and the science of improving sleep quality.  The conversation challenges conventional thinking about sleep, including whether everyone needs eight hours, why trying harder to fall asleep can make insomnia worse, and how the body's internal clock influences energy, productivity, and recovery.  Dr. Breus explains why he believes fear and anxiety contribute to a substantial proportion of sleep problems. He describes how worrying about falling asleep, waking up at 3 a.m., or feeling exhausted the next day can create a cycle of stress that makes restful sleep increasingly difficult. Dave and Michael explore how cognitive behavioral therapy, emotional regulation, and changing your relationship with sleep may help break that cycle without relying exclusively on medication.  They also examine the science of chronotypes, the biological differences that influence when people naturally feel alert or sleepy. Michael explains why aligning sleep, work, meals, and exercise with your individual circadian rhythm may improve sleep efficiency and daytime performance. Dave shares how changing his exposure to artificial light and adjusting his daily routines helped him shift from being a night owl to maintaining an earlier bedtime.  The discussion then turns to the three physiological conditions Michael considers essential for falling asleep: lowering core body temperature, reducing heart rate, and decreasing anxiety. He explains why simply turning down the thermostat may not be enough to cool your body under the covers, how temperature-controlled mattresses can support thermoregulation, and why something as simple as warming your feet may help your body release heat.  Dave and Michael also discuss blue light, nighttime lighting, and the environmental signals that regulate circadian timing. They examine why light exposure, meal timing, exercise, temperature, and social interaction can influence the body's internal clock, along with the limitations of conventional blue-light-blocking glasses.  The conversation explores why sleeping pills may fail to address the underlying causes of chronic insomnia, how nighttime awakenings can trigger negative thinking, and why the fear of being tired may sometimes become more disruptive than the tiredness itself. Dave shares his experience deliberately restricting sleep while building his businesses, and Michael explains the difference between temporarily functioning with less sleep and maintaining healthy sleep habits over the long term.  They also challenge the growing obsession with sleep scores, deep sleep measurements, and wearable tracking devices. Michael explains why consumer sleep trackers cannot provide the same measurements as a clinical sleep study, why individual sleep-stage estimates should be interpreted cautiously, and why how you feel in the morning remains an important indicator of sleep quality.  Finally, Dave and Michael examine emerging research on creatine supplementation and sleep deprivation, including whether creatine can temporarily support cognitive performance after insufficient sleep. They discuss the potential benefits, limitations, and risks of using supplements to compensate for lost sleep, emphasizing why improving sleep quality should remain the priority.  This episode is essential listening for anyone interested in insomnia, sleep anxiety, waking up at 3 a.m., circadian rhythms, chronotypes, sleep optimization, blue light, temperature regulation, sleep medications, cognitive behavioral therapy, wearable sleep trackers, deep sleep, creatine, cognitive performance, longevity, and the science of getting better sleep.  You'll Learn:  Why Dr. Michael Breus believes fear and anxiety contribute to many sleep problems, and how worrying about sleep can make insomnia worse How your chronotype influences your ideal bedtime, wake-up time, energy levels, and the amount of sleep you may need Why lowering body temperature, heart rate, and anxiety can help you fall asleep faster and improve sleep quality How nighttime light exposure, meal timing, exercise, and bedroom temperature influence circadian rhythms and sleep Why waking up at 3 a.m. can trigger negative thinking, and how changing your response to nighttime awakenings may help What sleep trackers get wrong about deep sleep, how to interpret your sleep data, and whether creatine can help when you're sleep-deprived  Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living.  New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient.  Keywords: Michael Breus, Dr. Michael Breus, The Sleep Doctor, Dave Asprey, The Human Upgrade, sleep expert, insomnia, sleep anxiety, sleep disorders, sleep problems, sleep quality, sleep optimization, how to fall asleep, waking up at 3am, circadian rhythm, chronotypes, sleep cycles, sleep deprivation, deep sleep, REM sleep, blue light, blue light blocking glasses, bedroom temperature, thermoregulation, sleep trackers, Oura Ring, sleep scores, cognitive behavioral therapy, sleeping pills, creatine, cognitive performance, biohacking, longevity   Resources:  • Learn More About Michael’s Work At: http://chronoquiz.com/  • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/  • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.  • Danger Coffee: https://dangercoffee.com/discount/davetube  • My Daily Supplements: SuppGrade Labs (15% Off)  • Favorite Blue Light Blocking Glasses: TrueDark (15% Off)  Thank you to our sponsors!       - KILLSwitch | If you’re ready for the best sleep of your life, order now at https://www.switchsupplements.com/ and use code DAVE for 20% off  - ZenBud | Dave’s Nervous System Biohack. Visit zenbud.health and use code DAVE15 at checkout for a discount.  - fatty15 | Go to fatty15.com/DAVE to get an additional 15% off their 90-day Starter Kit.  - MOD | Visit https://mod.com/ for a consultation and get 10% off your first order plus free shipping with promo code DAVE.  Timestamps:   00:00 — Trailer  01:27 — Intro  02:46 — Chronotypes & Sleep Compression  05:00 — Blue Light Glasses Debate  07:50 — Night Owls & Morning Meetings  12:15 — Circadian Time Cues  14:21 — Temperature & Thermoregulation  19:58 — EMFs & Sleep Sensitivity  25:01 — Sleep Research & Fear  30:28 — Sleep Deprivation Experiment  36:15 — Trackers & Creatine  See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Explore Calroy's vascular health and joint support supplements, including Arterosil, Vascanox, and Cartigenix, at https://calroy.com/dave  Cartilage Regeneration, Joint Pain, Nitric Oxide, Blood Flow, Muscle Strength & Longevity with Kiran Krishnan  Host Dave Asprey sits down with Kiran Krishnan, research microbiologist, systems biology researcher, and co-founder of Microbiome Labs, to explore cartilage regeneration, joint pain, osteoarthritis, nitric oxide, vascular health, inflammation, muscle growth, gut health, bone density, and the biological mechanisms that influence how the body ages.  Kiran Krishnan is a research microbiologist, health and wellness expert, and entrepreneur who specializes in the human microbiome, gut health, inflammation, and systems biology. Over the past 20 years, he has founded several successful health and supplement companies, including co-founding and leading Microbiome Labs, a leading microbiome therapeutics brand among healthcare professionals. He is also a co-founder and partner in three other health companies. Kiran has conducted and published scientific research, contributed chapters to scientific textbooks, holds global patents, and is a sought-after speaker on human health and the microbiome.  His latest work explores the relationship between blood vessel health, chronic inflammation, and the body's ability to repair damaged cartilage. Through research involving compounds designed to support vascular function, nitric oxide production, and joint health, Kiran is investigating whether age-related tissue degeneration can be slowed or potentially reversed.  Dave opens the conversation by sharing his lifelong struggle with joint pain, including an arthritis diagnosis at age 14 and three knee surgeries. Kiran explains why cartilage degeneration may begin long before symptoms appear and how declining blood flow, damaged microvessels, and chronic inflammation can interfere with the body's natural cartilage repair mechanisms.  They explore the role of the endothelial glycocalyx, the protective lining inside blood vessels, and why nitric oxide production becomes increasingly important with age. Kiran explains how impaired circulation can affect everything from joint lubrication and cartilage health to cognitive performance, digestion, muscle recovery, and sexual function.  Kiran also discusses research involving Cartigenix, a joint support supplement developed using compounds from Boswellia and celery seed. He describes clinical trials involving patients with osteoarthritis, including reported improvements in joint pain, inflammation, and cartilage regeneration, even among older adults with advanced joint degeneration. Dave and Kiran examine how Cartigenix, Arterosil, and Vascanox target different aspects of joint and vascular health, while distinguishing the Cartigenix trial results from the proposed benefits of combining all three products.  The conversation then shifts to practical strategies for improving circulation and metabolic health. Dave and Kiran discuss why walking after meals may help regulate blood sugar, how the cephalic response prepares the digestive system for food, and why excessive endurance exercise may create trade-offs for recovery and long-term health.  They also challenge conventional thinking about muscle growth and longevity. Kiran explains why functional strength may matter more than muscle size, how nitric oxide and microcirculation influence the delivery of amino acids to muscle tissue, and why maintaining healthy blood vessels could be an overlooked factor in preserving strength as you age.  Finally, Kiran previews emerging research on bone regeneration, gut health, and a new postbiotic-based formulation being developed for bone health, particularly during perimenopause and menopause. He shares early findings involving bone repair and osteocyte production, while Dave explains why maintaining strong bones, healthy joints, and efficient circulation should be foundational priorities for anyone interested in longevity.  This episode is essential listening for anyone interested in cartilage regeneration, osteoarthritis, chronic joint pain, nitric oxide, blood circulation, vascular health, inflammation, muscle growth, strength training, gut health, bone density, menopause, cellular repair, supplements, biohacking, and the science of maintaining physical performance as you age.  You’ll Learn:  Why cartilage breaks down with age and how impaired blood flow and chronic inflammation interfere with joint repair What Kiran's clinical research suggests about cartilage regeneration and joint recovery in people with osteoarthritis How nitric oxide and the endothelial glycocalyx influence circulation, cardiovascular health, cognitive function, and longevity Why functional strength may be more important than muscle size for healthy aging, and how blood flow affects muscle growth and recovery How walking after meals, supporting digestion, and improving vascular function may benefit blood sugar regulation and gut health What emerging research suggests about bone regeneration, postbiotics, and maintaining bone density during menopause and aging  Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living.  New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient.  Keywords: Kiran Krishnan, Dave Asprey, The Human Upgrade, cartilage regeneration, cartilage repair, joint pain, osteoarthritis, arthritis, knee pain, joint health, bone on bone arthritis, Cartigenix, Calroy, Arterosil, Vascanox, nitric oxide, blood flow, vascular health, endothelial glycocalyx, chronic inflammation, Boswellia, muscle growth, muscle strength, strength training, muscle recovery, gut health, microbiome, bone density, bone regeneration, longevity, anti aging, biohacking   Resources:  • Grab A Discount On Calroy's Vascular Health And Joint Support Supplements, Including Arterosil, Vascanox, and Cartigenix, at https://calroy.com/dave  • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/  • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.  • Danger Coffee: https://dangercoffee.com/discount/davetube  • My Daily Supplements: SuppGrade Labs (15% Off)  • Favorite Blue Light Blocking Glasses: TrueDark (15% Off)  Thank you to our sponsors!       - ALP | Go to alppouch.com, code DAVE for 10% off.  - Visit www.myvitalc.com/davesfav to unlock Dave’s discount  - Our Place | Upgrade your kitchen with Our Place today. Visit fromourplace.com/DAVE and use code DAVE for 10% off sitewide.  - Omni-Biotic | Discover your formula at OmnibioticLife.com. Take 20% off your first order with code ASPREY.  Timestamps:   00:00 — Trailer  01:05 — Intro  04:44 — The Glycocalyx Explained  10:30 — Why Joints Degrade  15:16 — Rebuilding Cartilage  21:17 — Nitric Oxide & Gut Health  26:28 — Hacking the Cephalic Response  31:23 — Strength vs. Size for Longevity  37:47 — Muscle Building Supply System  42:51 — New Bone Regeneration Product  See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Try TrueDark glasses: https://truedark.com Try Danger Coffee: https://dangercoffee.com/discount/davetube Try Suppgrade Labs: https://shopsuppgradelabs.com/ This video reveals that the brain has a documented neurological focus state driven by prefrontal cortex activation and norepinephrine signaling that most people access accidentally but can learn to trigger reliably. Dave explains the biological mechanism and the specific supplement and behavioral stack that activates this state within 20 minutes. You'll Learn: Why your brain has a neurochemical "focus switch" and how to flip it on in about 20 minutes, with no extra willpower or motivationHow norepinephrine and dopamine work together to lock you into deep focus, and what happens when only one of them is presentWhy chronic stress, poor sleep, and sitting all day drain the exact chemicals your focus depends onHow L-tyrosine gives your brain the raw materials to make focus chemicals, and the dose and timing that workWhy the 1:2 ratio of caffeine to L-theanine beats coffee alone for working memory, accuracy, and calm, sustained concentrationWhich options like modafinil and Rhodiola rosea support norepinephrine and dopamine, and how they compareHow morning light and five minutes of movement set your focus chemistry for the entire dayWhy focus is never about effort, and how the right chemistry makes deep work feel effortless Thank You To Our Sponsors: -Butcher Box | Go to ButcherBox.com/HUMANUPGRADE to get $20 off your first box, plus your choice of free ground beef for life, or free chicken thigh -ECHO Water | Go to http://echowater.com/dave and use code DAVE10 for 10% off your ECHO Flask. -BrainTap | Go to http://braintap.com/dave to get $100 off the BrainTap Power Bundle. -iRestore | Unlock your best hair & skin with @iRestorelaser and HUGE savings on iRESTORE with code DAVE at irestore.com/DAVE Timestamps:  00:00 — The Focus Switch 01:44 — Habit One: Chronic Stress 03:38 — Habit Two: Bad Sleep 04:58 — Habit Three: Sitting 06:21 — Norepinephrine and Dopamine 09:40 — L-Tyrosine 10:41 — Caffeine and L-Theanine 12:30 — Modafinil and Rhodiola 14:42 — The 20-Minute Protocol 17:34 — The Right Fuel Connect with Dave Asprey! Website: https://daveasprey.com TikTok: https://www.tiktok.com/@daveaspreyofficial Instagram: https://www.instagram.com/dave.asprey/ Facebook: https://www.facebook.com/Daveaspreyofficial/ X: https://x.com/daveasprey YouTube: https://www.youtube.com/c/daveaspreybpr See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Infections Were Linked to About 1 in 8 Cancer Cases Worldwide  A new global analysis estimates that infections were responsible for roughly 2.3 million new cancer cases in 2024, about 12% of all cancers worldwide. H. pylori and HPV were the largest contributors, followed by hepatitis B, Epstein-Barr virus, and hepatitis C. Host Dave Asprey explores how persistent infections can contribute to cancer through chronic inflammation, DNA damage, altered immune surveillance, and other biological pathways. He explains why this does not mean cancer is contagious or that infection inevitably leads to cancer, but argues that identifying, preventing, and treating infections such as H. pylori, hepatitis B, and hepatitis C can be an overlooked part of a long-term prevention strategy.  Sources:  -IARC: Global Burden of Cancer Attributable to Infections in 2024  -PubMed: Global Burden of Cancer Attributable to Infections in 2024  ~~~~  What We Really Know About Persistent Finasteride Side Effects  Finasteride reduces the conversion of testosterone into DHT by inhibiting 5-alpha reductase, but that enzyme also participates in pathways involved in neuroactive steroids. Some former users report persistent sexual, cognitive, mood, and physical symptoms after stopping the drug, a collection of symptoms commonly called post-finasteride syndrome. Small studies have reported differences in neurosteroids, gene expression, androgen signaling, and peripheral nerve function among symptomatic former users, but these studies cannot establish that finasteride caused those changes or determine how common persistent symptoms are. Host Dave Asprey examines the evidence between the two extremes, neither dismissing persistent symptoms nor assuming that finasteride permanently damages everyone who takes it. European regulators have also recognized suicidal ideation as a possible adverse effect of oral finasteride, although its frequency remains unknown.  Sources:  -EMA: Finasteride and Dutasteride Safety Review  -PubMed: Neuroactive Steroids After Finasteride Discontinuation  PubMed: Neuroactive Steroids and Features in Post-Finasteride Patients  PubMed: Differential Gene Expression in Post-Finasteride Syndrome  ~~~  One Cup of Blueberries a Day Improved Measures of Vascular Function  In a six-month randomized controlled trial involving 115 adults with metabolic syndrome, consuming the equivalent of one cup of blueberries per day improved endothelial function and a measure of arterial stiffness, while a half-cup dose did not produce the same effects. Host Dave Asprey explains why describing blueberries simply as “antioxidants” misses much of their biology. Anthocyanins and other polyphenols can interact with gut microbes and influence vascular, inflammatory, and nitric oxide-related signaling. He also examines a small smoothie experiment showing that the polyphenol oxidase found in bananas sharply reduced the circulating metabolites of certain flavan-3-ols, while emphasizing that the experiment did not prove bananas erase the benefits of blueberries.  Sources:  -American Journal of Clinical Nutrition: Blueberries and Cardiometabolic Function  -Food & Function: Polyphenol Oxidase and Flavan-3-ol Bioavailability  ~~~  Vitamin D Matters to Male Reproductive Biology, But It Is Not a Fertility Treatment  Vitamin D receptors are present throughout the male reproductive system, and vitamin D signaling may influence processes involved in sperm motility and fertilization. Observational research has linked low vitamin D with poorer sperm motility, but clinical outcomes are less straightforward. In a randomized trial of 330 vitamin D-insufficient infertile men, supplementation raised vitamin D levels but did not improve overall semen parameters. Researchers observed potentially interesting signals involving spontaneous pregnancy and live birth among a subgroup of men with low sperm counts, but those findings require confirmation. Host Dave Asprey explains why correcting a vitamin D deficiency still makes sense while arguing that male fertility needs to be evaluated as a larger system involving metabolic health, sleep, heat exposure, medications, hormones, micronutrients, toxins, oxidative stress, and semen testing.  Sources:  -PubMed: Vitamin D Supplementation, Semen Quality and Live Birth Rate  ~~~  CoQ10 Shows Why a Great Mechanism Does Not Guarantee a Great Treatment  CoQ10 plays a central role in mitochondrial energy production and electron transport, making it an appealing candidate for diseases involving mitochondrial dysfunction, oxidative stress, and neuronal energy failure. Early biological reasoning and smaller studies looked promising, but larger clinical trials have repeatedly failed to show the expected neurological benefits. A randomized trial of 600 people with early Parkinson’s disease found no evidence that high-dose CoQ10 slowed disease progression, while a large Huntington’s disease trial was stopped early for futility. A Phase II ALS trial also found insufficient evidence to justify moving to a larger Phase III study. Host Dave Asprey uses CoQ10 as a broader lesson in biohacking: a supplement can have a legitimate biological function while still failing to improve the clinical outcome you care about.  Sources:  -PubMed: High-Dose CoQ10 in Early Parkinson Disease  -Neurology: CoQ10 in Huntington Disease  -PubMed: Phase II CoQ10 Trial in ALS  ~~~  This episode is designed for biohackers, longevity enthusiasts, men thinking about hair loss or fertility, and anyone trying to distinguish a compelling biological mechanism from a proven intervention. Host Dave Asprey examines how chronic infections contribute to cancer risk, what the evidence really says about persistent finasteride symptoms, why blueberries may influence vascular health through polyphenol signaling, where vitamin D fits into male fertility, and why CoQ10 is a powerful example of promising biology failing to translate into clinical outcomes. The larger lesson is simple: understand the mechanism, look for meaningful human outcomes, measure your own biology, and avoid confusing a plausible explanation with proof that an intervention works.  Keywords: infection cancer risk, cancer causing infections, H pylori cancer, HPV cancer, Epstein Barr virus cancer, chronic infection cancer, finasteride side effects, post finasteride syndrome, finasteride neurosteroids, allopregnanolone finasteride, DHT hair loss, blueberries cardiovascular health, blueberries endothelial function, blueberry polyphenols, anthocyanins gut microbiome, banana smoothie polyphenols, polyphenol oxidase, vitamin D male fertility, vitamin D sperm quality, male infertility, CoQ10 mitochondria, CoQ10 Parkinson’s disease, CoQ10 neurodegeneration, mitochondrial health, biohacking research roundup  Thank you to our sponsors!   - Butcher Box | Go to ButcherBox.com/HUMANUPGRADE to get $20 off your first box, plus your choice of free ground beef for life, or free chicken thigh  - The One Device | Use code DAVE for $10 off at theonedevice.com/dave  - Viome | Check it out at viome.com and use code 10DAVE for 10% off. It’s time to stop guessing and start knowing your body.  - iRestore | Unlock your best hair & skin with @iRestorelaser and HUGE savings on iRESTORE with code DAVE at irestore.com/DAVE  Resources:    • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/  • Get My 2026 Biohacking Trends Report: https://daveasprey.com/2026-biohacking-trends-report/  • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.   • Danger Coffee: https://dangercoffee.com/discount/dave15    • My Daily Supplements: SuppGrade Labs (15% Off)    • Favorite Blue Light Blocking Glasses: TrueDark (15% Off)    • Dave Asprey’s BEYOND Conference: https://beyondconference.com    • Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated   • Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/  • Upgrade Labs: https://upgradelabs.com      Timestamps:  00:00 — Intro  00:45 — Infections From 2024  02:15 — Finasteride Concerns  04:38 — Blueberries and Bananas  06:40 — Vitamin D and Fertility  08:18 — CoQ10 Trial Failures  09:47 — Takeaway  See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Get a free digital and audiobook copy of Angelic Attendants at https://askjulieryan.com/request-ebook/  Psychic Abilities, Medical Intuition, Energy Healing, Remote Viewing & What Happens When We Die with Julie Ryan  Host Dave Asprey sits down with Julie Ryan, psychic, medical intuitive, inventor, author, entrepreneur, and host of the Ask Julie Ryan podcast, to explore intuition, consciousness, energetic healing, remote viewing, communication with spirits, past lives, dreams, and what Julie says happens as people approach death.  Julie Ryan is a psychic and medical intuitive who says she can sense medical conditions, facilitate energetic healings, communicate with spirits, scan animals, access past lives, and tell how close someone may be to death. She is also an inventor, author, radio host, podcaster, and serial entrepreneur who has founded nine companies across five industries. Her surgical device inventions are sold globally, and unlike many people working in the intuitive space, Julie says her psychic and medical intuitive abilities were learned.  Her book Angelic Attendants: What Really Happens As We Transition From This Life Into The Next explores what she describes as the process of dying, including the presence of angels, deceased family members, friends, pets, and other experiences that may occur near the end of life.  Julie explains how she went from building companies and inventing surgical devices to learning psychic and medical intuitive skills she now teaches to others. She describes how she believes people can remotely sense information about the body, distinguish intuition from ordinary thoughts, and develop abilities that often get ignored or shut down as people grow older.  Dave and Julie explore what it means to “scan” someone from a distance, how Julie says she perceives injuries and illness inside the body, and why she sees intuition as another form of information processing rather than something reserved for a small group of gifted people. Julie also explains why visual, auditory, and kinesthetic learners may experience intuitive information differently.  They also discuss energetic healing, emotional trauma, brainwave patterns, spiritual experiences during surgery, communication with deceased loved ones, and the role dreams may play in receiving intuitive information. Dave shares his own experiences with intuition, altered brain states, grief, and the peaceful death of his mother.  This episode is essential listening for anyone interested in psychic abilities, intuition, consciousness, energy healing, remote viewing, medical intuition, dreams, the afterlife, grief, near-death awareness, spirituality, neuroscience, and the possibility that human perception may extend beyond what most people are trained to notice.  You’ll Learn:  How Julie says psychic and medical intuitive abilities can be learned and trained How she remotely “scans” the body and interprets information about illness, injury, and healing How to tell the difference between intuition and ordinary thoughts or emotions What Julie says happens spiritually during surgery, dreams, and communication with deceased loved ones How her 12 phases of transition may indicate when someone is approaching death Why Dave believes intuition and science can overlap, especially in observation, discovery, and consciousness research  Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living.  New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient.  Keywords: Julie Ryan, psychic abilities, psychic powers, medical intuitive, medical intuition, intuition, intuitive abilities, energy healing, energetic healing, remote viewing, consciousness, spirituality, afterlife, what happens when you die, death and dying, near death, spirit communication, communicating with spirits, deceased loved ones, past lives, psychic training, intuitive training, spiritual healing, dreams, vivid dreams, grief, angels, guardian angels, consciousness research, neuroscience, brainwaves, psychic brain, spiritual experiences, emotional healing, energy medicine, mind body connection, holistic healing, biohacking, human potential, Dave Asprey, The Human Upgrade   Resources:  • Get A Free Digital And Audiobook Copy Of Angelic Attendants At https://askjulieryan.com/request-ebook/  • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/  • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.  • Danger Coffee: https://dangercoffee.com/discount/davetube  • My Daily Supplements: SuppGrade Labs (15% Off)  • Favorite Blue Light Blocking Glasses: TrueDark (15% Off)  Thank you to our sponsors!       - Butcher Box | Go to ButcherBox.com/HUMANUPGRADE to get $20 off your first box, plus your choice of free ground beef for life, or free chicken thigh  - ZenBud | Dave’s Nervous System Biohack. Visit zenbud.health and use code DAVE15 at checkout for a discount.  - Caldera + Lab | If you're looking for one simple product that actually makes a difference, that's The Great, visit CalderaLab.com/DAVE and use code DAVE for 20% off your first order.  - Calroy | Learn more about Selentra HP and get your exclusive discount at calroy.com/dave  Timestamps:   00:00 — Trailer  01:00 — Psychic Powers  03:52 — Scanning Through Spirit  07:02 — First Intuitive Knowing  14:10 — Fairies and Elementals  17:29 — No Evil Spirits  23:11 — Medical Intuition   32:00 — The Energy Field Membrane  37:43 — Spirits in the Operating Room  46:17 — Dreams, Mold, and Lyme  54:04 — What Happens as We Die  See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Grab 20% off KORA Organics with code HUMAN20 at https://koraorganics.pxf.io/9VdD0E.  Clean Living, Stress Reduction, Sleep, Skincare & Simple Wellness Habits with Miranda Kerr  Host Dave Asprey sits down with Miranda Kerr, founder of KORA Organics, entrepreneur, model, and longtime wellness advocate, to explore clean living, stress, sleep, skincare, meditation, parenting, and why her approach to health has become simpler over time.  Miranda shares how her mother’s cancer diagnosis when she was 16 changed the way her family looked at everyday ingredients and helped spark her lifelong interest in organic living, holistic health, and reducing unnecessary exposures. That experience later became a driving force behind KORA Organics and her focus on certified organic skincare.  They explore the habits Miranda now prioritizes after years of experimenting with wellness, including morning sunlight, quality food, meditation, sleep, breathwork, strong relationships, and time with family. She also explains how she manages stress while raising four children and running an international company.  Dave and Miranda discuss raising healthy kids without making health feel restrictive, navigating different health values within a family, and why acceptance matters when you cannot control another person’s choices.  The episode also covers clean beauty, plant-based retinol alternatives, non-nano zinc sunscreen, essential oils, rose quartz, intention, and the philosophy behind KORA Organics. Miranda also explains why constantly chasing new wellness tools eventually pushed her back toward a smaller set of foundational habits that consistently make her feel better.  This episode is essential listening for anyone interested in clean living, stress reduction, meditation, sleep, healthy parenting, skincare, organic beauty, biohacking, and building a wellness routine that supports your life rather than taking it over.   You’ll Learn:  Why Miranda’s mother’s health scare changed the way she thought about food, skincare, and everyday ingredients Why her wellness routine has become simpler instead of more complicated over time The foundational habits Miranda prioritizes for energy, stress, sleep, and overall health How meditation, breathwork, morning sunlight, and evening light management fit into her daily routine How she teaches her children about healthy food without creating fear or restriction Why acceptance matters when your partner does not share the same health priorities How Miranda approaches clean beauty, organic skincare, retinol alternatives, and non-nano mineral sunscreen Why KORA Organics incorporates rose quartz, positive words, essential oils, and intention into its products How constantly experimenting with wellness tools can become counterproductive Why sunlight, sleep, food, relationships, and stress management remain the foundation even after years of exploring wellness  Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living.  New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient.  Keywords: Miranda Kerr, KORA Organics, clean living, clean beauty, wellness, healthy living, holistic health, skincare, organic skincare, certified organic skincare, healthy skin, anti-aging skincare, skin health, non-nano zinc sunscreen, mineral sunscreen, retinol alternative, bakuchi oil, meditation, TM meditation, breathwork, stress reduction, stress management, sleep, circadian rhythm, morning sunlight, blue light, grounding, healthy parenting, raising healthy kids, nutrition, toxins, environmental toxins, ingredient safety, essential oils, rose quartz, mindset, intention, biohacking, healthy aging, wellness routine, simple wellness, holistic wellness  Resources:  • Grab 20% Off KORA Organics with code HUMAN20 at https://koraorganics.pxf.io/9VdD0E  • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/  • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.  • Danger Coffee: https://dangercoffee.com/discount/davetube  • My Daily Supplements: SuppGrade Labs (15% Off)  • Favorite Blue Light Blocking Glasses: TrueDark (15% Off)    Thank you to our sponsors!       - KILLSwitch | If you’re ready for the best sleep of your life, order now at https://www.switchsupplements.com/ and use code DAVE for 20% off  - Neuronic | Go to www.neuronic.online Code DAVE for $100 off  - Puori | Use code DAVE at puori.com/DAVE to get 32% off your first Puori CP1 Pure Collagen order when you start a subscription. You save more than $26.  - LMNT | Right now, grab any LMNT drink mix and they'll throw in a free sample pack. Go to drinklmnt.com/dave to get yours.  Timestamps:   00:00 — Trailer  00:51 — Miranda’s Health Awakening  06:21 — Mind, Body & Crystals  13:12 — Roots of Positive Thinking  17:04 — The McDonald's Birthday Hack  22:36 — Acceptance in Relationships  28:34 — Intention Behind the Products  32:28 — Proving Organic Skincare Works  36:56 — Stress & Morning Rituals  42:09 — Back to Basics  48:17 — Health Without Public Pressure  51:06 — Closing Thoughts  See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Try TrueDark glasses: https://truedark.com Try Danger Coffee: https://dangercoffee.com/discount/davetube Try Suppgrade Labs: https://shopsuppgradelabs.com/ I'm in the best shape of my life, and it has nothing to do with working harder. In this video, I break down the 5 unconventional hacks that helped me lose over 100 pounds, kill brain fog, and feel two decades younger, starting with something as simple as what I put in my morning coffee. If you're tired of doing everything 'right' and still feeling old, this one's for you. You'll Learn: How putting grass-fed butter and MCT oil in your coffee can unlock steady energy and effortless fat lossWhy eating more saturated fat, not less, supports your brain, hormones, and metabolismHow the "calories in, calories out" myth keeps you stuck and why food quality matters far more than quantityWhich "healthy" foods like spinach, oats, and beans are packed with anti-nutrients that cause inflammation and block nutrient absorptionHow intermittent fasting flips your body from sugar-burning to fat-burning mode and triggers cellular repairWhy dialing in your nutrition beats grinding in the gym and how over-exercising can actually stall fat loss and speed up aging Timestamps: 00:00 — The 300-Pound Millionaire 01:26 — Discovery in Tibet 03:05 — Eat More Saturated Fat 04:38 — The Low-Fat Scam 07:01 — Quality Over Quantity 09:20 — Hidden Plant Toxins 12:04 — Watch the Fructose 13:08 — Skip Breakfast 16:38 — Diet Beats the Gym Thank you to our sponsors! - Butcher Box | Go to ButcherBox.com/HUMANUPGRADE to get $20 off your first box, plus your choice of free ground beef for life, or free chicken thigh -EMR-Tek | https://www.emr-tek.com/DAVE and use code DAVE for 40% off. -iRestore | Unlock your best hair & skin with @iRestorelaser and HUGE savings on iRESTORE with code DAVE at irestore.com/DAVE Connect with Dave Asprey! Website: https://daveasprey.com TikTok: https://www.tiktok.com/@daveaspreyofficial Instagram: https://www.instagram.com/dave.asprey/ Facebook: https://www.facebook.com/Daveaspreyofficial/ X: https://x.com/daveasprey YouTube: https://www.youtube.com/c/daveaspreybpr The Human Upgrade Podcast: https://www.instagram.com/TheHumanUpgradePodcast/ https://m.facebook.com/Thehumanupgrade/ Danger Coffee: https://dangercoffee.com/discount/dave15? Dave Asprey’s BEYOND Conference: https://beyondconference.com/ Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/ Dave's favorite supplements: https://www.shopsuppgradelabs.com/discount/DAVE15 Join my Substack: https://substack.daveasprey.com Upgrade Labs: https://upgradelabs.com 40 Years of Zen: https://40yearsofzen.com See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Vagus Nerve Stimulation Improves Cognitive Scores in a Small Trial  In a 24-week trial involving people with mild cognitive impairment, participants assigned to electrical stimulation at vagus-innervated parts of the ear improved by an average of 3.2 points on a general cognitive test, compared with 0.3 points in a sham-stimulation group. Host Dave Asprey explores the proposed connection between the vagus nerve and the locus coeruleus, a brainstem region involved in attention and learning. He explains why an improved test score is intriguing but does not show that vagus nerve stimulation prevents Alzheimer’s disease—or that a consumer device will reproduce the study’s results.pubmed.ncbi.nlm.nih+1  Sources:  https://pubmed.ncbi.nlm.nih.gov/36150665/  https://pmc.ncbi.nlm.nih.gov/articles/PMC13214873/  https://theconversation.com/vagus-nerve-stimulation-shows-promise-as-a-way-to-counter-alzheimers-disease-and-age-related-memory-loss-269465  ~~~ Nearly 500 Cat Tumors Reveal Cancer Genes Shared With Humans  Researchers analyzed 493 matched tumor and normal-tissue samples across 13 types of cancer in domestic cats. They found alterations in genes familiar to human cancer researchers, including TP53, and tested whether a mutation called FBXW7 might predict drug sensitivity in lab-grown models of feline mammary tumors. Host Dave Asprey examines why naturally occurring cancers in pets could help scientists investigate treatments across species, while making clear that a promising response in six laboratory tumor models is not a proven treatment for cats or people.pmc.ncbi.nlm.nih  Sources:  https://pmc.ncbi.nlm.nih.gov/articles/PMC7618901/  https://pubmed.ncbi.nlm.nih.gov/41712721/  https://www.sciencedaily.com/releases/2026/09/260924231826.htm  ~~~ Twin-Family Study Challenges a Simple Explanation for Inherited Intelligence  Why do parents and children often score similarly on tests of cognitive ability? Researchers using Germany’s TwinLife data found that genetic transmission explained more of that resemblance than the particular shared-home-environment pathway their model tested. Host Dave Asprey unpacks the distinction between why relatives resemble one another and whether a child’s environment matters. The study does not show that parenting, education, or other experiences have no effect on cognition.pub.uni-bielefeld+1  Sources:  https://pub.uni-bielefeld.de/record/2993432  https://www.psypost.org/genetics-not-shared-environments-drives-parent-child-similarities-in-cognitive-ability/  ~~~ Mulberry Compounds May Change Gut Bacteria and Metabolism  A review of mulberry research highlights how leaves, fruit, and differently processed extracts contain distinct mixtures of compounds that gut microbes may use. In mouse experiments, a fraction combining mulberry polyphenols and polysaccharides produced more favorable microbiome and metabolic changes than either fraction alone; transferring microbes from treated mice passed along some of those effects. Host Dave Asprey explores the idea that a plant extract’s preparation may matter as much as its name—and why the findings do not yet establish a microbiome benefit from mulberry products in humans.pmc.ncbi.nlm.nih+1  Sources:  https://pmc.ncbi.nlm.nih.gov/articles/PMC13406227/  https://www.sciencedaily.com/releases/2026/09/260928100551.htm  ~~~ Magnesium Changes Vitamin D Metabolism—But Not Always in the Same Direction  Magnesium helps regulate the pathways that process vitamin D, but “more magnesium means more vitamin D” is too simple. In a 12-week randomized trial involving 180 adults, magnesium supplementation changed a measured vitamin D metabolite differently depending on participants’ starting vitamin D levels: the modeled difference was positive at 30 ng/mL and negative at 50 ng/mL. Host Dave Asprey explains why this matters to people tracking supplement stacks and bloodwork, while distinguishing a change in a lab marker from a demonstrated health benefit.pubmed.ncbi.nlm.nih+1  Sources:  https://pmc.ncbi.nlm.nih.gov/articles/PMC6693398/  https://pubmed.ncbi.nlm.nih.gov/29480918/  https://www.sciencedaily.com/releases/2018/02/180226122548.htm  This episode is designed for biohackers, longevity enthusiasts, pet owners, parents, and anyone trying to separate a compelling biological mechanism from a proven health intervention. Host Dave Asprey examines brain stimulation and memory, what cat cancers could teach human researchers, how genes and environment contribute to cognitive similarity, whether mulberry’s microbiome effects translate beyond mice, and why nutrient interactions are rarely as simple as a supplement headline suggests. Several studies discussed here predate this week’s coverage; this is a research roundup, not a list of five newly published trials.pmc.ncbi.nlm.nih+4  New episodes every Tuesday, Thursday, Friday, and Sunday.  Keywords: vagus nerve stimulation memory, auricular vagus nerve stimulation, mild cognitive impairment, Alzheimer’s research, locus coeruleus, cat cancer genetics, feline oncogenome, FBXW7 feline mammary cancer, comparative oncology, parent child cognitive ability, TwinLife cognitive ability study, intelligence genetics, shared environment cognition, mulberry gut microbiome, mulberry polyphenols polysaccharides, microbiota transfer mice, magnesium vitamin D metabolism, magnesium supplementation vitamin D, biohacking research roundup  Thank you to our sponsors!   - Butcher Box | Go to ButcherBox.com/HUMANUPGRADE to get $20 off your first box, plus your choice of free ground beef for life, or free chicken thigh  - Beyond Wonderland Conference | Oct 13 - 14, 2026. Get your ticket now at wonderlandconference.com.  - The One Device | Use code DAVE for $10 off at theonedevice.com/dave  - iRestore | Unlock your best hair & skin with @iRestorelaser and HUGE savings on iRESTORE with code DAVE at irestore.com/DAVE  Resources:    • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/  • Get My 2026 Biohacking Trends Report: https://daveasprey.com/2026-biohacking-trends-report/  • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.   • Danger Coffee: https://dangercoffee.com/discount/dave15    • My Daily Supplements: SuppGrade Labs (15% Off)    • Favorite Blue Light Blocking Glasses: TrueDark (15% Off)    • Dave Asprey’s BEYOND Conference: https://beyondconference.com    • Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated   • Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/  • Upgrade Labs: https://upgradelabs.com    Timestamps:  00:00 — Intro  00:18 — Vagus Nerve  01:51 — Cat Cancer  03:53 — Genetics & Parenting  05:46 — Mulberries  07:43 — Magnesium & Vitamin D  09:25 — Takeaway  See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Visit https://www.younggoose.com/ and use code ASPREY10 to save on the skin longevity products discussed in this episode.  Skin Longevity, Cellular Repair, Red Light Therapy & the Biology of Younger Skin with Young Goose  Host Dave Asprey sits down with Amitay Eshel and Anastasia Khodzhaeva, co-founders of Young Goose, to explore the emerging science of skin longevity, cellular aging, mitochondrial function, exosomes, NAD+, red light therapy, and what it may take to keep skin functioning younger for longer.  Anastasia is a biologist, biohacker, and co-CEO of Young Goose who began her career in biomedical research focused on liver fibrosis and breast cancer before moving into wellness, product development, and longevity-focused skincare. Amitay is co-founder and CEO of Young Goose and host of the Biohacking Beauty podcast, with more than a decade of experience across health, wellness, beauty, and business development. Together, they focus on applying longevity science and performance optimization to skin health.  Amitay and Anastasia explain why wrinkles may be only one visible sign of a much deeper biological process involving declining cellular energy, weakened barrier function, oxidative stress, senescence, and changes in how skin cells repair themselves. They break down how newer approaches to skincare are moving beyond surface-level hydration toward targeting the cellular mechanisms associated with aging.  The conversation goes deep into testing, including a metabolomics-based approach designed to assess skin metabolic age from a small blood sample and analyze 17 different metabolites. They also discuss emerging proteomics testing that can examine thousands of proteins involved in processes such as collagen production, oxidative stress, mitochondrial function, and cellular repair.  Dave, Amitay, and Anastasia explore some of the most unusual compounds now being used in skin longevity, including methylene blue, NAD+ precursors, spermidine, ergothioneine, superoxide dismutase, copper peptides, ectoin, and gotu kola. They explain how these compounds may interact with mitochondrial energy production, oxidative stress, mitophagy, collagen signaling, and the broader hallmarks of aging.  They also break down red light therapy and why combining light with certain topical compounds may influence the response. The discussion covers methylene blue and electron transport, copper peptides and mitochondrial biogenesis, light-activated DNA repair enzymes, photodamage, reactive oxygen species, and why dose and timing may matter when using red or near-infrared light.  The episode also dives into platelet-derived “Vampire Exosomes,” how exosomes carry cellular instructions through microRNAs, why formulation and stability matter, and how these signaling particles may influence skin repair, inflammation, collagen production, and senescence. Dave and the Young Goose team also discuss growth factors, klotho, senomorphic strategies, cellular longevity, and why extending the functional life of healthy cells may become an important frontier in longevity science.  They also explore practical skincare routines, including how to layer products, what Dave uses while traveling, how airplanes and dry environments affect skin, why aggressive acids may not always fit a long-term skin longevity strategy, and how AI-based skin analysis could make skincare increasingly personalized.  This is essential listening for anyone interested in skin longevity, anti-aging skincare, exosomes, methylene blue, NAD+, red light therapy, mitochondrial health, senescent cells, collagen, peptides, cellular repair, metabolomics, proteomics, biohacking, and the future of personalized skincare.  You’ll Learn:  Why wrinkles may be a downstream sign of deeper cellular aging How skin metabolic age can be assessed using metabolomics and multiple biological markers What methylene blue may do inside mitochondria and why it pairs with red light How NAD+ precursors, spermidine, copper peptides, SOD, and ergothioneine may support skin biology Why platelet-derived “Vampire Exosomes” are being studied for cellular signaling, repair, and senescence How red light therapy interacts with mitochondrial function, oxidative stress, and DNA repair Why some traditional acids and surface-level skincare strategies may not address long-term skin function How proteomics and AI could change the way skincare is measured and personalized What Dave and the Young Goose team use to support skin during travel and other high-stress environments  Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living.  New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient.  Keywords: Amitay Eshel, Anastasia Khodzhaeva, Young Goose, Biohacking Beauty, skincare, anti-aging skincare, skin longevity, skin aging, younger skin, exosomes, vampire exosomes, platelet-derived exosomes, methylene blue, NAD+, NAD precursors, red light therapy, mitochondria, mitochondrial health, mitochondrial dysfunction, cellular aging, cellular repair, senescent cells, senescence, senomorphics, collagen, copper peptides, GHK-Cu, spermidine, ergothioneine, superoxide dismutase, SOD, ectoin, gotu kola, mitophagy, metabolomics, proteomics, skin metabolic age, klotho, oxidative stress, peptides, skin barrier, DNA repair, photodamage, biohacking, longevity  Resources:     • Visit https://www.younggoose.com/ and use code ASPREY10 to save on the skin longevity products discussed in this episode.  • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/    • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.     • Danger Coffee: https://dangercoffee.com/discount/davetube  • My Daily Supplements: SuppGrade Labs (15% Off)      • Favorite Blue Light Blocking Glasses: TrueDark (15% Off)      Thank you to our sponsors!       - Download Dave’s Free Peptide Guide at daveasprey.com/peptide-guide.  - Neuronic | Go to www.neuronic.online Code DAVE for $100 off  - Timeline | Go to timeline.com/dave and get up to 20% off when you subscribe and save  - Kenetik | Instead of pushing your system harder, Kenetik feeds your brain the ketones it craves to fuel calm clarity and steady focus. Go to drinkkenetik.com/DAVE and use code DAVE for a discount.  Timestamps:   00:00 — Trailer  01:09 — Skin Testing & Metabolomics  04:48 — Longevity Skincare Paradigm  07:50 — Airplane Skincare Routine  11:15 — Tardigrade Juice & Antioxidants  16:00 — Mitochondrial Dysfunction  21:00 — Skincare Ingredients: Old vs New  27:20 — Vampire Exosomes  32:30 — Red Light Therapy Stacking  38:00 — Proteomics & Klotho  41:00 — Exosome Safety, Growth Factors & MicroRNAs  44:00 — Senescent Cells & Senomorphics  47:00 — Skin Longevity Takeaways 50:00 — Outro  See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Visit LoveYourLiver.com and use code Dave2026 to access the special offer from de-liver-ance mentioned in this episode. Host Dave Asprey sits down with Siggi Clavien, Founder and CEO of The Liver Clinic and de-liver-ance, to explore why the liver may be one of the most overlooked organs in metabolism, hormone health, detoxification, brain function, weight management, and longevity.  Siggi explains why fatty liver can develop without obvious symptoms and why someone can appear lean and healthy while still have significant liver fat. Drawing on thousands of liver scans, he shares what his team has observed in people whose blood markers appeared normal despite signs of fatty liver on imaging, and explains how tools such as FibroScan can reveal liver fat, stiffness, and fibrosis.  Dave and Siggi go deep into triglycerides, cholesterol, insulin resistance, brain fog, weight gain, bile production, thyroid hormone activation, testosterone, estrogen metabolism, and liver regeneration. They also explore how alcohol, environmental chemicals, plastics, processed foods, artificial sweeteners, medications, and other exposures may place additional stress on the liver.  The conversation also tackles rapid weight loss and GLP-1 medications, including Siggi’s concerns about compounds released from fat tissue during aggressive weight loss and why protecting muscle, eating enough protein, and supporting liver function may matter during the process.  Dave and Siggi also discuss alcohol, estrogen, hormone replacement therapy, glutathione, choline, bile flow, supplement quality, and why liver health may influence systems throughout the body. The episode takes an unexpected turn into microchimerism and organ transplantation, including donor cells, DNA, cellular memory, and reported changes in behavior or personality after transplantation.  This is essential listening for anyone interested in fatty liver, metabolic health, GLP-1s, weight loss, hormone health, estrogen, testosterone, thyroid function, alcohol, brain fog, insulin resistance, liver scans, longevity, choline, glutathione, bile flow, and biohacking.  You’ll Learn:  Why fatty liver can develop even in people who are thin or rarely drink alcohol Why normal bloodwork may not always reveal what is happening inside the liver How liver health connects to metabolism, brain fog, weight gain, hormones, and thyroid function What rapid weight loss and GLP-1 use may mean for liver function How alcohol, estrogen, HRT, bile, choline, and glutathione interact with liver health Why liver scans, nutrition, and supplement quality may matter for long-term health  Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living.  New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient.  Keywords: Siggi Clavien, de-liver-ance, The Liver Clinic, liver health, fatty liver, fatty liver disease, MASLD, liver detox, liver function, liver scan, FibroScan, liver fibrosis, triglycerides, cholesterol, metabolic health, GLP-1, weight loss, toxins, alcohol, estrogen, HRT, testosterone, thyroid health, brain fog, insulin resistance, bile, choline, glutathione, artificial sweeteners, supplements, longevity, liver regeneration, microchimerism, biohacking  Resources:     • Visit LoveYourLiver.com and use code Dave2026 to access the special offer from de-liver-ance mentioned in this episode.  • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/    • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.     • Danger Coffee: https://dangercoffee.com/discount/davetube  • My Daily Supplements: SuppGrade Labs (15% Off)      • Favorite Blue Light Blocking Glasses: TrueDark (15% Off)      Thank you to our sponsors!       - KILLSwitch | If you’re ready for the best sleep of your life, order now at https://www.switchsupplements.com/and use code DAVE for 20% off  - MOD | Visit mod.com for a consultation and get 10% off your first order plus free shipping with promo code DAVE.  - ZenBud | Dave’s Nervous System Biohack. Visit zenbud.health and use code DAVE15 at checkout for a discount.  - Mars Men | For a limited time, our listeners get 50% off for life plus Free Shipping AND 3 Free Gifts when you checkout at MenGoToMars.com.  Timestamps:   00:00 — Trailer  01:00 — Liver Basics & Signs  05:30 — Liver Scan Technology  08:15 — Chemicals & Liver Disease  11:30 — Deliverance Formula Story  17:15 — Estrogen, Alcohol & HRT  22:30 — GLP-1s & Liver Toxicity  28:00 — Bile & Gut Health  33:10 — Chimerism & Transplants  41:30 — Hormesis & Painkillers  50:00 — Sweeteners, Hormones & Thyroid  55:00 — Outro - Discount  See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Try TrueDark glasses: https://truedark.com Try Danger Coffee: https://dangercoffee.com/discount/davetube Try Suppgrade Labs: https://shopsuppgradelabs.com/ Try Longevity Gummies: https://www.timeline.com/partners/dave-asprey This video explains the most effective ways to lose visceral fat, escalating from least to most effective, like a caloric deficit & diet quality (high protein, cut alcohol), Aerobic exercise (cardio), resistance training, sleep optimization, and stress reduction. If diet and exercise aren't melting stubborn belly fat, fix your sleep first with 300mg of Magnesium 101 before bed, available at https://shopsuppgradelabs.com/discount/DAVETUBE?redirect=/products/magnesium-101 with code DAVETUBE for 15% off. You'll Learn: Why protein burns 20–30% of its own calories just to digest — and how that "thermic effect" makes it the most powerful diet lever for cutting visceral fatWhy short, intense workouts (as little as 10–20 minutes a week) beat long cardio sessions for triggering fat-burning hormonesHow cold exposure activates brown fat to burn visceral fat as fuel, and why consistency matters more than intensityWhy resistance training is one of the most effective tools for long-term fat loss, not just muscle-buildingHow poor sleep tanks growth hormone by up to 70% a night and drives up cortisol, both of which directly promote visceral fat storageWhy chronic stress is the single biggest driver of visceral fat, and how it creates a self-reinforcing loop that resists diet and exercise alone Thank you to our sponsors! Butcher Box | Go to ButcherBox.com/HUMANUPGRADE to get $20 off your first box, plus your choice of free ground beef for life, or free chicken thighViome | Check it out at viome.com and use code 10DAVE for 10% off. It’s time to stop guessing and start knowing your body.iRestore | Unlock your best hair & skin with @iRestorelaser and HUGE savings on iRESTORE with code DAVE at irestore.com/DAVE Timestamps: 00:00 — Introduction & Calorie Myth 01:27 — Power of Protein 02:37 — Cut Sugar & Carbs 03:48 — HIIT for Fat Loss 05:44 — Cold Exposure 06:32 — Resistance Training 08:22 — Sleep & Growth Hormone 10:30 — Stress & Cortisol 13:39 — Breaking the Fat Loop Connect with Dave Asprey! Website: https://daveasprey.com TikTok: https://www.tiktok.com/@daveaspreyofficial Instagram: https://www.instagram.com/dave.asprey/ Facebook: https://www.facebook.com/Daveaspreyofficial/ X: https://x.com/daveasprey YouTube: https://www.youtube.com/c/daveaspreybpr The Human Upgrade Podcast: https://www.instagram.com/ TheHumanUpgradePodcast/ https://m.facebook.com/Thehumanupgrade/ Upgrade Labs: https://upgradelabs.com 40 Years of Zen: https://40yearsofzen.com See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.