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We now have the power to quickly and easily alter DNA. It could eliminate disease. It could solve world hunger. It could provide unlimited clean energy. It could get really out of hand.  Written by Amy Maxmen. Originally published in August 2015. For more of the most ambitious, future-defining stories from our favorite human writers, subscribe to The Big Story newsletter: https://www.wired.com/newsletter/the-big-story Learn more about your ad choices. Visit podcastchoices.com/adchoices

Every day, Wikipedia biographies of living people are flagged for deletion because the subjects are not “notable” enough. How do these poor souls take the news? Written by Duncan Fyfe. Originally published on October 26th 2026. For more of the most ambitious, future-defining stories from our favorite human writers, subscribe to The Big Story newsletter: https://www.wired.com/newsletter/the-big-story Learn more about your ad choices. Visit podcastchoices.com/adchoices

Earth is teeming with unknown species, and they’re dying off faster than ever. Now biologists are battling over an old question: how to catalog life? Written by Brooke Jarvis. Originally published on November 10th 2022. For more of the most ambitious, future-defining stories from our favorite human writers, subscribe to The Big Story newsletter: https://www.wired.com/newsletter/the-big-story Learn more about your ad choices. Visit podcastchoices.com/adchoices

Sneaking six Americans out of Iran in 1979 would take an audacious plan, false identities, and an epic Hollywood cover story. Written by Joshuah Bearman. Originally published on April 24th, 2007. For more of the most ambitious, future-defining stories from our favorite human writers, subscribe to The Big Story newsletter: https://www.wired.com/newsletter/the-big-story Learn more about your ad choices. Visit podcastchoices.com/adchoices

To escape the chaos of her Russian childhood, Lili Infante became an American law enforcement prodigy. She pioneered the DEA’s investigations of the dark web—never suspecting who she’d find hiding there. Written by Joshuah Bearman and Owen Long. Originally published on October 21st, 2026. For more of the most ambitious, future-defining stories from our favorite human writers, subscribe to The Big Story newsletter: https://www.wired.com/newsletter/the-big-story Learn more about your ad choices. Visit podcastchoices.com/adchoices

They thought their payments were untraceable. They couldn’t have been more wrong. The untold story of the case that shredded the myth of Bitcoin’s anonymity. Written by Andy Greenberg. Originally published on April 7th, 2022. For more of the most ambitious, future-defining stories from our favorite human writers, subscribe to The Big Story newsletter: https://www.wired.com/newsletter/the-big-story Learn more about your ad choices. Visit podcastchoices.com/adchoices

He shed his identity with the goal of disappearing for one month. Then the manhunt began. Written by Evan Ratliff. Originally published on November 20th, 2009. For more of the most ambitious, future-defining stories from our favorite human writers, subscribe to The Big Story newsletter: https://www.wired.com/newsletter/the-big-story Learn more about your ad choices. Visit podcastchoices.com/adchoices

Including what Elizabeth Holmes said to him last week. A WIRED exclusive interview with the comic auteur, as his first feature film hits theaters. The conversation between Katie Drummond and Nathan Fielder is performed by voice actors. These are not their actual voices. Written by Katie Drummond. Originally published on October 19th, 2026. For more of the most ambitious, future-defining stories from our favorite human writers, subscribe to The Big Story newsletter: https://www.wired.com/newsletter/the-big-story Learn more about your ad choices. Visit podcastchoices.com/adchoices

Maddie Kowalski is one of countless young women who’ve had their lives destroyed by the burnerverse, a loosely connected online community of sports fans. Now she’s fighting back. Written by EJ Dickson. Originally published on September 14th, 2026. For more of the most ambitious, future-defining stories from our favorite human writers, subscribe to The Big Story newsletter: https://www.wired.com/newsletter/the-big-story Learn more about your ad choices. Visit podcastchoices.com/adchoices

Microsoft spawned two billionaires. Paul Allen is the other one. Written by Paulina Borsook. Originally published on August 1st, 1994. For more of the most ambitious, future-defining stories from our favorite human writers, subscribe to The Big Story newsletter: https://www.wired.com/newsletter/the-big-story Learn more about your ad choices. Visit podcastchoices.com/adchoices

A cat wearing a short tie plays music on a cat-shaped keyboard (“Pancake Meowsic Video,” 185,459 views). A woman performs sun salutations with a cat on her back (“Cat Loves Yoga,” 1,539 views). A man slaps two cats on an ironing board to the beat of “Atmosphere” (“Cat Slap Joy Division,” 357,605 views). Written by Gideon Lewis-Kraus. Originally published on August 31st, 2012. For more of the most ambitious, future-defining stories from our favorite human writers, subscribe to The Big Story newsletter: https://www.wired.com/newsletter/the-big-story Learn more about your ad choices. Visit podcastchoices.com/adchoices

Soon, hundreds of new top-level domains, including .meow and .fart, could be added to the internet. WIRED goes inside the backroom shenanigans of ICANN, the organization at the helm. Written by Pete Millspaugh. Originally published on October 6th, 2026. For more of the most ambitious, future-defining stories from our favorite human writers, subscribe to The Big Story newsletter: https://www.wired.com/newsletter/the-big-story Learn more about your ad choices. Visit podcastchoices.com/adchoices

Right now, there are no rules to keep you from owning a bitchin’ corporate name as your own internet address. Written by Joshua Quittner. Originally published on October 1st, 1994. For more of the most ambitious, future-defining stories from our favorite human writers, subscribe to The Big Story newsletter: https://www.wired.com/newsletter/the-big-story Learn more about your ad choices. Visit podcastchoices.com/adchoices

Our most powerful 21st-century technologies—robotics, genetic engineering, and nanotech—are threatening to make humans an endangered species. Written by Bill Joy. Originally published on April 1st, 2000. For more of the most ambitious, future-defining stories from our favorite human writers, subscribe to The Big Story newsletter: https://www.wired.com/newsletter/the-big-story Learn more about your ad choices. Visit podcastchoices.com/adchoices

Lost time. Lost jobs. Lost friends. Lost family. Lost Lives. How Israeli checkpoints suffocate Palestinian life in the occupied West Bank. Written by Lama Rabah, Sabrina Slipchenko, Charles Boutaud, Firas Tawil and Elena DeBre. Originally published on September 30th 2026. For more of the most ambitious, future-defining stories from our favorite human writers, subscribe to The Big Story newsletter: https://www.wired.com/newsletter/the-big-story Learn more about your ad choices. Visit podcastchoices.com/adchoices