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Program notes: 0:34 Chronotrope type and timing of exercise 1:36 Sedentary adults and morning or evening type 2:36 Acting as your own control 3:10 Stenting for post thrombotic syndrome 4:10 Severity lower with endovascular therapy 5:10 Patent in 2/3 at six months 6:10 Very diverse patient populations 6:28 Estimating kidney function 7:28 Currently underestimate compromise 8:27 Deprescribing proton pump inhibitors 9:27 Three different interventions 10:27 Almost 15% achieved outcome in both patient and physician 12:08 End

Program notes: 0:36 How low should cholesterol be targeted in secondary prevention? 1:40 33% reduction with target to 55 2:36 Able to do it with statin and other drugs 3:03 Deprescribing levothyroxine 4:06 Were able to discontinue in many  5:05 Thyroid not as responsive with aging 6:05 Barriers to deprescribing? 6:31 Treatment of HTN in low-income patients 7:31 75% unemployed 8:31 Patient participates 9:06 Manufacturer coupon use 10:10 Annual patient use of coupons 11:18 Used to drive people to use drugs that are expensive 12:33 End

Program notes: 0:38 Migrating biopharma industry 1:36 Early stage development 2:36 Need to replicate studies 3:23 Treatment for fatigue from long Covid 4:25 Fluvoxamine or metformin 5:25 Only fluvoxamine helped 6:25 Only for fatigue 6:35 How treatments for hepatitis C have been used 7:36 Number of people receiving treatment declining 8:36 Need a better system 9:16 Dulaglutide or tirzepatide and patient reported outcomes 10:17 Quality of life metrics 11:43 End

Program notes: 0:36 High versus standard-dose flu vaccines in older people 1:36 Cardiovascular outcomes 2:26 Also in those with previous CVD 3:10 Cooking and dementia risk 4:10 Cooking frequency and skills assessment 5:10 Tasks relative to preparing a meal at home 6:10 Encourage home cooking 6:30 Asymptomatic aortic stenosis treatment 7:30 Replace valve before symptoms 8:30 Trained cardiologist can grade 9:10 Pediatric sepsis in U.S. hospitals 10:17 About 51,000 cases 11:17 Adult criteria may not be in EHR 12:29 End

Program notes: 0:35 New cholesterol lowering guidelines 1:35 Risk scores new 2:35 Mainstay is behavioral change 3:35 For those with a longer view 4:00 AI based glaucoma screening in primary care settings 5:00 Either AI or pressure 6:00 Fundus photograph and intraocular pressure 7:00 Sensitivity and specificity 7:50 Diet and brain structure 8:50 Brain imaging over ten or fifteen years 9:50 Diet that's been advocated for a long time 10:55 Surveying wastewater for colorectal cancer markers 11:55 CDH1 marker measurement 12:55 Shows promise for intervention 13:57 End

Program notes: 0:44 Adolescents and sleep duration 1:44 Very short sleep duration 2:44 Increased among all subgroups 3:45 Structural factors more important 4:45 Moving school start later 5:02 GLP1 agonists and various patient characteristics 6:02 Greater weight loss in women 7:06 A blood test to predict onset of symptomatic Alzheimer's 8:06 Median error of 3-4 years 9:06 Window of 11.4 years for an 80 year old 10:05 Screening for colorectal cancer  11:05 Colonoscopy and FIT diagnosed early 12:33 End

Program notes: 0:37 HIV treatment monthly injections 1:37 Long acting and effective 2:37 Some didn't come for monthly injections 3:16 COVID-19 vaccination and preeclampsia rate 4:16 In two successive cohorts during pandemic 5:16 Pre-existing morbidity 58% reduction 6:15 COVID-19 cytokine storm? 6:45 Monkeypox treatment 7:45 Randomized to placebo or smallpox drug 8:50 Menstrual blood to test for HPV 9:50 Minipad essentially the same as clinician collection 10:45 Can make it cost effective? 11:49 End

Program notes: 0:37 Hormone therapy and mortality 1:37 Those who used versus those unexposed 2:35 Different types of HT 3:32 Adolescent cannabis use and mental illness 4:32 Screened in physician office 5:32 Action at societal and government levels 6:00 Access to dialysis facilities and SES 7:01 2.3 % of advantaged communities lacked access 8:01 For profit centers consolidate 9:01 Roughly half of nephrology spots unfilled 9:33 ACOs and Medicare savings 10:33 Initial study showed net savings 11:16 Fragile savings estimate 12:09 End 

Program notes: 0:35 Diabetes and food prescriptions 1:35 Got a food card to purchase nutritious foods 2:32 More than half didn't use it or used it less than 60% 3:00 Adequacy of a planetary health diet 4:00 Micronutrient intake and biomarkers 5:00 Doesn't seem to compromise long-term health 6:12 Statin recommendations and patient preferences 7:00 Benefit/risk analysis for patients 8:00 Patient's decisions are multifactorial 9:00 Resistance to daily medication 9:30 Findings on shoulder MRI 10:35 Rotator cuff abnormalities in almost 99% 11:35 Almost ubiquitous regardless of symptoms 12:25 Physical therapy best strategy 13:23 End

Program notes: 0:38 Removal of fallopian tubes to prevent ovarian ca 1:43 129 studies included 2:43 Women who no longer desire pregnancy 3:40 Technically feasible 4:30 New oral PCSK9 inhibitor 5:35 Think it's a slam dunk 6:08 EHR helping deprescribing in older adults 7:08 Two sequential EHR interventions 8:08 40% more likely in one group 9:08 Something in email less effective 9:50 Benefits of knee braces for OA 10:50 Brace specific to area of OA 12:00 If it results in a placebo effect 13:00 End

Program notes: 0:50 Rapid recovery of hearts for transplant after circulatory death 1:50 Total ischemic time longer than 4 hours 2:50 Typically reanimate 3:50 Expanded to donors 40 years of age 4:55 Do women with PCOS have increased risk for arrhythmia 5:55 Incidence arrhythmia in these women increased risk 6:50 An LLM to streamline transitions from primary to secondary care 7:50 Used alone, with staff support, or control 8:51 Decreased amount of time in the consult 9:52 Things that accumulate data will be embraced 10:12 Treating gout to prevent CVD 11:12 Lowered in about a fourth of patients 12:36 End

Program notes: 0:45 Impact on kids of parental firearm injury or death 1:46 Eight additional psychiatric diagnoses per 100,000 2:39 Lifetime stress, inflammation and racial disparities in mortality 3:40 Black individuals shorter survival 4:40 Precise number is difficult to understand 5:40 Self-report 6:45 If a woman has known CVD, can she discontinue statins in pregnancy? 7:45 No difference in woman's health 8:45 Over a 14-year period 9:00 Policy compliance in leading tobacco brands 10:00 Instagram, FTC and FDA policies 11:00 Cut across all types of nicotine products 12:59 End

Program notes: 0:40 Two MMWR reports on wastewater to detect measles 1:40 Subsequent detection after early identification 2:40 Watch worldwide transition 3:15 Weight regain after medication for weight management 4:16 Cardiometabolic risk factors return in just over a year 5:16 Willingness to use declined with knowledge of regain risk 6:16 Prevention of obesity 6:33 Chronic kidney disease and heart failure link 7:35 Extracellular vesicles found 8:35 Precise identification of a tangle pathway 9:03 Physical activity types, varieties and mortality 10:03 Higher variety conferred additional survival benefit 11:03 Will you change your behavioral? 12:03 Lower hypertension, BMI 12:39 End

Program notes: 0:38 Childhood vaccinations nationally 1:30 Across 45 states and DC 2:34 Level of vaccine protection 3:34 Professional societies stepping in 3:51 Skilled nursing facilities  4:51 Estimated operating capacity 5:51 Backups into hospitals 6:51 Staffing not returned to pre-pandemic levels 7:35 Prescribing patterns of CNS active meds in older adults 8:36 Several classes of medication examined 9:36 Last line medications 9:50 Mifepristone regulation historically 10:50 Consistent findings on safety 11:50 FDA looking at REMS 12:50 End

Program notes: 0:35 Global pain burden 1:35 Prevalence increased in 15 countries 2:35 Higher prevalence in older people but not consequence of aging 3:02 Tertiary patents 4:03 in the Orange Book 5:05 Prolonged patent protection and higher prices 6:07 Focused on high revenue products 6:50 Detecting DVT better 7:51 Age specific D-dimer cutoffs 8:51 Age and morbidity factors 9:23 Infant screen time and adolescent anxiety 10:24 Multiple intermediate assessments 11:24 Accelerates development 12:47 End