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Program notes: 0:45 Imaging for cardiac stent placement 1:45 12 month target vessel failure 2:38 Treatment resistant depression and psychedelic medicine 3:38 Three dosages and psychological support 4:38 Adverse events same among all groups 5:38 Will it last longer than 60 days? 6:36 Need to compare head to head 7:00 One in thirteen people have achilles tendinopathy 8:00 Initial improvement with steroids then rapid decline 9:00 People must be patient 9:10 HER-2 positive early breast cancer giving chemo a miss 10:10 Utilizing PET imaging 11:10 A third responded just to antibodies 12:47 End

Program notes: 0:35 Continuous glucose monitoring in Type 2 diabetes not using insulin 1:40 Decreased HbA1c 2:35 Already shown to be beneficial in those using insulin 3:30 Cancer vaccines 4:30 Disease-free survival endpoint 5:32 If T-cell population increased 6:30 Pregnancy outcomes in women who donate kidneys 7:30 Matched 4-to-1 with nonkidney donors 8:30 Timing of kidney donation 9:15 AI collaboration for managing epilepsy 10:15 Links EEGs to AI and smartphone app 11:15 Patients requested continuation 12:45 End

Program notes: 0:40 Clinician use of AI clinically 1:40 703,000 active monthly users 2:40 How helpful is this? 3:40 More up to date 3:50 Prognostic model to estimate fetal compromise 4:50 Data from singleton births  5:50 Fit4labour model 6:50 Could be used 8 hours before a problem 7:11 Drug coated balloons or stent 8:11 Indications are symptoms or high risk 8:40 US donor heart allocation 9:40 Best interests of their patient 10:40 Similar or significantly higher area under the curve  11:40 Can identify a higher risk group 12:54 End

Program notes: 0:36 HPV vaccines and pregnancy outcomes 1:36 600,000+ births 2:36 What is the mechanism? 3:30 Adult ADHD 4:30 May see underperformance 5:30 Almost always methylphenidate or amphetamine 6:30 Public health significance 7:01 Hospital closures in the U.S. 8:01 Safety net, non-teaching hospitals closed more 9:03 Advance care planning in black and white older adults 10:04 Racially concordant or discordant facilitator 11:08 Self-guided planning 12:10 Not doing a good job offering ACP 13:59 End

Program notes: 0:40 Lean metabolic associated liver disease 1:40 Biopsy confirmed MASLD 2:40 Elastography for diagnosis 3:41 Liver transplant often needed 4:04 HT and thromboembolic disease 5:04 VTE, ischemic stroke and MI 6:04 Oral estrogen increased risk 7:07 LIquid cancer biopsy impact 8:07 Not had cancer compared to routine screening 9:07 Not seeing a positive impact 10:05 Inter-interval breast cancers 10:31 How to manage early septic shock 11:31 Main outcome alive and out of the hospital at day 90 12:30 Both are equally effective 13:20 End

Program notes: 0:33 Statins for older people without CVD 1:34 Followed for six years 2:34 Aged to 70 without CVD 3:00 Improving primary care for folks with chronic conditions 4:00 70,000 respondents 5:00 Long term relationship with a primary care provider 6:00 Continuity and coordination can be delivered at scale 7:09 Treating advanced breast cancer 8:10 Mutation in estrogen receptor 9:12 Targeting specific mutations 10:00 A new target for managing asthma and COPD 11:00 Healthy volunteers and patients with asthma 12:00 Typically treated with immunosuppression 13:05 End

Program notes: 0:40 Structured exercise after cancer 1:40 Moderate evidence 2:40 Improves overall survival 3:41 Improves drug penetration 4:00 Colonoscopy intervals after polyp removal 5:00 Five-year cumulative incidence same as three years 6:03 Covid vaccination and immune checkpoint therapy 7:03 Mortality as primary outcome 8:04 Multiple benefits of vaccination 9:03 Other vaccines of benefit? 9:50 Does sodium bicarbonate help in critical illness and shock 10:50 Metabolic acidosis tx 11:50 Largely futile 12:37 End

Program notes: 0:37 New stroke therapy 1:37 Use of IV for 10 days after stroke 2:37 Present late after a stroke 3:39 Long term outcomes of top-down therapy in Crohn's 4:40 Outcomes up to five years 5:40 Early TNF use from diagnosis improves outcomes 6:42 No real downside 7:38 How much oxygen for 32–35-week neonates? 8:34 Ongoing respiratory support needed? 9:34 Not hypoxic to begin with 9:50 Feeding eggs and peanuts during pregnancy 10:50 Did not impact risk for infant allergy 11:50 One third dropped out 13:03 End

Program notes: 0:33 Vaccines for RSV, flu, and Covid 1:35 Studies available right now 2:33 Reduction of hospital encounters for infants 3:33 Maternal vaccination for RSV 4:34 Gene silencing therapy for cardiomyopathy 5:35 Decreased primary outcome about 20% 6:35 Should we be screening? 7:06 A new protein to pinpoint preeclampsia 8:05 Low levels in first trimester 9:08 Anchors embryo to uterus 10:05 A new therapy for COPD exacerbations 11:05 Phase three trial of monoclonal 12:34 End

Program notes: 0:44 EKG monitoring and syncope 1:45 No difference when monitored 2:45 Why not try monitoring? 3:13 Catheter directed thrombolysis in PE 4:14 Composite of death from any cause 5:14 Assessment for intermediate or high risk 6:16 Treatment not onerous 6:45 Afib ablation versus sham 7:45 Did not improve quality of life 8:45 Preprocedure assessment of psychological state? 9:13 Digital intervention to protect cognitive health 10:13 Verbal reasoning at 12 months 11:13 As long as internet is available 12:15 What happens at five-year follow-up 13:09 End

Program notes: 0:37 CTE and dementia in NFL players 1:37 Post mortem CTE presence and stage 2:35 Past look at brains of players who died 3:35 Lesion is perivascular tau 4:34 Warning on repeated head trauma 5:14 IV iron for anemia before cardiac surgery 6:14 Anemic before surgery? 7:17 Hospice in rural and urban areas 8:18 People 66 years or older who died 9:20 Length of stay shorter, private or nursing homes 10:20 Doesn't limit hospice care 10:33 ADHD and CVD 11:33 About a 30% increase in CVD 12:45 End

Program notes: 0:35 Devices to do CPR versus manual 1:37 About 60% of U.S. population 2:32 8-9% survive with favorable neurologic status 3:15 Ventilated patients and reduction of mucous secretions 4:15 Duration of ventilation unchanged 5:15 Regulate or expectorate 5:40 Boarding ED patients 6:45 Adults admitted to general medicine service 7:45 More common in older patients 8:45 Can initiate inpatient management 9:24 Cold stored platelets versus room temp 10:24 Hemostatic efficiency score 11:30 Historically used in cancer patients 12:45 End

Program notes: 0:38 Polymyalgia rheumatica treatment 1:35 Antibody targets interleukin 17a 2:35 Remission started at 12 weeks and was durable to 52 3:11 Cannabis and hyperemesis syndrome 4:11 Cannabis-related ED visits 5:11 Prior to the new coding didn't link 6:05 Gene inhibition of PCSK-9 7:05 Encased in a nanoparticle 8:11 Three vascular risk factors and dementia 9:11 Stratified by age, sex, apoE status 10:13 13 additional dementia-free years 11:58 End

This week's topics include caffeine's impact on CVD, antihistamines and atopic dermatitis, a community designed diet for heart failure, and e-cigarettes after smoking cessation.

Program notes: 0:44 Novel agent for acute pain 1:44 Post-abdominal surgery and placebo, low and high dose 2:46 Compared to placebo and opioids 3:19 Metabolic associated steatotic liver disease 4:19 Imaging with two techniques and plasma markers 5:19 Imaging and composite scores for staging 6:21 Identifying appropriate candidates for clinical trials 7:00 Alcohol consumption during pregnancy 8:00 Employed, tobacco use, and mental stress predicts 9:01 Never tested medicines for AUD in pregnant women 9:24 Early detection of Alzheimer's disease with circular RNA 10:24 Can it identify those with the disease as well as those at risk 11:24 Almost 95% AUC 12:20 Use with tau, it was even better 13:05 End