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You've built an awesome set of APIs and you have a wide array of devices and clients using them. Then you need to upgrade an end point or change them in a meaningful way. Now what? That's the conversation I dive into over the next hour with Stanislav Zmiev. We're talking about Versioning APIs.

Building web UIs in Python has always been in interesting proposition. On one end, we have a the full web design story with artisanal HTML and CSS. On another end there are several Python platforms that aim to the bring RAD, rapid app development, style of building with Python. Those can be great, and I've covered a couple of them, but they usually reach a limit on what they can do or how they integrate with the larger web ecosystem. On this episode, we have Samuel Colvin to share his latest exciting project FastUI. With FastUI, you build responsive web applications using React without writing a single line of JavaScript, or touching npm. Yet designers and other tools can focus on React front-ends for a professional SPA like app experience.

So you've created a Python-based open source project and it's started to take off. You're getting contributors, lots of buzz in the podcast space, and more. But you have that day job working on Java. How do you make the transition from popular hobby project to full time job? After all, you are giving away your open source project for free, right? Well, on this episode, I have put together an amazing panel of guests who all have done exactly this: Turned their project into full time work and even companies in some cases. We have Samuel Colvin, Gina Häußge, Sebastián Ramírez, Charlie Marsh, Will McGugan and Eric Holscher on to share their stories.

It's an exciting time for the capabilities of Python. We have the Faster CPython initiative going strong, the recent async work, the adoption of typing and on this episode we discuss a new isolation and parallelization capability coming to Python through sub-interpreters. We have Eric Snow who spearheaded the work to get them added to Python 3.12 and is working on the Python API for 3.13 along with Anthony Shaw who has been pushing the boundaries of what you can already do with subinterpreters.

Why is Python so popular? There is plenty of room for debate on this but one solid reason is it's easy to adopt, easy to use, and caters to people who are not quite developers/data scientists but need to do some computing. Do you know where there largest untapped set of that group hang out? Excel. That's why it's super exciting that Python is now going to be built directly into Excel. Just go into a cell and type =PY and you're off writing full Python 3 code that is backed by a lite Anaconda distribution of Python. And we have Dr. Sarah Kaiser here to give us the rundown on Python in Excel.

When you run your code in the cloud, how much do you know about where it runs? I mean, the hardware it runs on and the data center it runs in? There are just a couple of hyper-scale cloud providers in the world. This episode is a very unique chance to get a deep look inside one of them: Microsoft Azure. Azure is comprised of over 200 physical data centers, each with 100,000s of servers. A look into how code runs on them is fascinating. Our guide for this journey will be Mark Russinovich. Mark is the CTO of Microsoft Azure and a Technical Fellow, Microsoft's senior-most technical position. He's also a bit of a programming hero of mine. Even if you don't host your code in the cloud, I think you'll enjoy this conversation. Let's dive in.

Are you early in your software dev or data science career? Maybe it hasn't even really started yet and you're still in school. On this episode we have Sydney Runkle who has had a ton of success in the Python space and she hasn't even graduated yet. We sit down to talk about what she's done and might do differently again to achieve that success. It's "The Young Coder's Blueprint to Success" on episode 444 of Talk Python To Me.

Special crossover episode of Python Bytes to wrap up 2023. Topics include: **Michael #1** : [Hatch v1.8](https://hatch.pypa.io/latest/blog/2023/12/11/hatch-v180/) **Brian #2:** [svcs : A Flexible Service Locator for Python](https://svcs.hynek.me/en/stable/) **Michael #3:** [Steering Council 2024 Term Election Results](https://discuss.python.org/t/steering-council- election-results-2024-term/40851) **Brian #4:** [Python protocols. When to use them in your projects to abstract and decoupling](https://typethepipe.com/post/python-protocols-when-to-use) ExtrasJoke: **Joke:** [The dream is dead?](https://mastodon.social/@tveskov/111289358585305218)

If you're a fan of Pydantic or dataclasses, you'll definitely be interested in this episode. We are talking about a super fast data modeling and validation framework called msgspec. Some of the types in here might even be better for general purpose use than Python's native classes. Join me and Jim Crist-Harif to talk about his data exchange framework, mspspec.

You've probably heard the term "syntactic sugar", that is, syntax within a programming language that is designed to make things easier to read or to express. It makes the language "sweeter" for human use. It turns out Brett Cannon has spent 2 years diving into and writing about Python's sweet language features and how they really work down inside CPython. He joins me on the show today to dive into a few of the more relevant posts he's written about it.

We all know that LLMs and generative AI has been working its way into many products. It's Jupyter's turn to get a really awesome integration. We have David Qiu here to tell us about Jupyter AI. Jupyter AI provides a user- friendly and powerful way to apply generative AI to your notebooks. It lets you choose from many different LLM providers and models to get just the help you're looking for. And it does way more than just a chat pane in the UI. Listen to find out.

On this episode we have Wolf Vollprecht and Ruben Arts from the pixi project here to talk about pixi, a high performance package manager for Python and other languages that actually manages Python itself too. They have a lot of interesting ideas on where Python packaging should go and are putting their time and effort behind them. Will pixi become your next package manager? Listen in to find out.