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2025 was, undoubtedly, the year of AI. In the first episode of 2026 Beezer Clarkson, Partner at Sapphire Partners, and Nick Chirls, Partner at Asylum Ventures revisit some of their favorite moments from the year before to see what the top voices in VC saw as emerging AI trendlines and how the venture ecosystem and global markets might respond next. In this episode we’ll hear from – among others – Sarah Tavel of Benchmark about what it means to be truly AI native, Sunil Dhaliwal & Mike Dauber of Amplify about finding technical VCs in the age of AI, and Micah Rosenbloom of Founder Collective on how early stage venture often misses major trends like AI until it’s too late. Learn more about Sapphire Partners: sapphireventures.com/sapphire-partners Learn more about OpenLP: openlp.vc Learn more about Asylum Ventures: asylum.vc Learn more about Benchmark: benchmark.com Learn more about Amplify: amplifypartners.com Learn more about Founder Collective: foundercollective.com Learn more about Curie.Bio: curie.bio Read Sarah’s Substack Posts: sarahtavel.com CHAPTERS: 0:00 Welcome to Origins 3:36 Being AI Native with Sarah Tavel 10:36 Finding Technical Founders with Mike Dauber & Sunil Dhaliwal 14:31 Early Stage Founders Are 7 Years Too Late with Micah Rosenbloom 23:04 What AI CAN’T Do with Zach Weinberg28:37-Technical vs. Product Genius with Sarah Tavel 38:49 Nick & Beezer’s AI Trends to Watch In 2026 For a monthly roundup of the latest venture insights, including the newest Origins episodes, subscribe to the OpenLP newsletter – delivered straight to your inbox: subscribe.openlp.vc Origins is produced by Sapphire Ventures in partnership with⁠ Pod People. Nothing presented herein is intended to constitute investment advice, and under no circumstances should any information provided herein be used or considered as an offer to sell or a solicitation of an offer to buy an interest in any investment fund managed by Sapphire Ventures, LLC (“Sapphire”). Any offer or solicitation of securities by Sapphire may only be made in accordance with the current offering documents for a managed Fund in which Sapphire is an advisor. Additionally, Sapphire does not solicit or make its services available to the public; such offerings may only be provided to accredited investors and qualified purchasers defined within the Securities Act of 1933 and the Investment Company Act of 1940. Information provided reflects Sapphire Ventures’ views as of a particular time. Such views are subject to change at any point and Sapphire Ventures shall not be obligated to provide notice of any change. Due to various risks and uncertainties, actual events, results or the actual experience may differ materially from those reflected or contemplated in these statements. While Sapphire Ventures has used reasonable efforts to obtain information from reliable sources, Sapphire makes no representations or warranties as to the accuracy, reliability, or completeness of third party information presented herein. Nothing presented herein may be relied upon as a guarantee or assurance as to the future success of any particular investment opportunity or strategy. Past performance is not indicative of future results.

Origins host Beezer Clarkson,  LP at Sapphire Partners and co-founder of OpenLP, and Nick Chirls, GP at Asylum Ventures, dig into their recent conversation with Micah Rosenbloom, Managing Partner at Founder Collective. They discuss the EQ and self-awareness required to switch from operator to investor, how to separate signal from noise in venture cycles, and how the speed of iteration is now such that a window of one or two days can change the entire calculus of an investment. Learn more about Sapphire Partners: sapphireventures.com/sapphire-partners Learn more about OpenLP: openlp.vc Learn more about Asylum Ventures: asylum.vc Learn more about Founder Collective: foundercollective.com For a monthly roundup of the latest venture insights, including the newest Origins episodes, subscribe to the OpenLP newsletter – delivered straight to your inbox: subscribe.openlp.vc CHAPTERS: 0:00 Welcome to Origins 0:34 How Involved Should Operators Be With Their CEOs? 2:16 VCs and Trends Are Seven Years Too Late 3:19 Repeat Portfolio Companies: Courageous Or Insane? 5:42 How Do VCs Handle the Speed of Iteration? Origins is produced by Sapphire Ventures in partnership with⁠⁠ Pod People.⁠ Nothing presented herein is intended to constitute investment advice, and under no circumstances should any information provided herein be used or considered as an offer to sell or a solicitation of an offer to buy an interest in any investment fund managed by Sapphire Ventures, LLC (“Sapphire”). Any offer or solicitation of securities by Sapphire may only be made in accordance with the current offering documents for a managed Fund in which Sapphire is an advisor. Additionally, Sapphire does not solicit or make its services available to the public; such offerings may only be provided to accredited investors and qualified purchasers defined within the Securities Act of 1933 and the Investment Company Act of 1940. Information provided reflects Sapphire Ventures’ views as of a particular time. Such views are subject to change at any point and Sapphire Ventures shall not be obligated to provide notice of any change. Due to various risks and uncertainties, actual events, results or the actual experience may differ materially from those reflected or contemplated in these statements. While Sapphire Ventures has used reasonable efforts to obtain information from reliable sources, Sapphire makes no representations or warranties as to the accuracy, reliability, or completeness of third party information presented herein. Nothing presented herein may be relied upon as a guarantee or assurance as to the future success of any particular investment opportunity or strategy. Past performance is not indicative of future results.

Micah Rosenbloom is a Managing Partner at Founder Collective, a firm dedicated to seed investing and, crucially, to keeping their fund sizes below $100 million. Micah talks with Beezer Clarkson, Partner at Sapphire Partners, and Nick Chirls, Partner at Asylum Ventures, to discuss Founder Collective’s philosophy of keeping their fund size small to avoid the “billions or bust” mentality, how most investors have a bad track record of spotting trends at seed, and how consumer goods are still worthwhile investments even against the backdrop of AI. They also debate a recent post from Nick to get to the fundamental question of whether investors taking big risks are courageous or lucky. Learn more about Sapphire Partners: sapphireventures.com/sapphire-partners Learn more about OpenLP: openlp.vc Learn more about Asylum Ventures: asylum.vc Learn more about Founder Collective: foundercollective.com For a monthly roundup of the latest venture insights, including the newest Origins episodes, subscribe to the OpenLP newsletter – delivered straight to your inbox: subscribe.openlp.vc CHAPTERS: 0:00 Welcome to Origins 2:16 What Can Small Do For You?8:57-A Whole Team of Ex Operators 14:52 How Micah’s View of the Market Has Changed18:48-Why the Market’s Tough Right Now 21:49 Early Stage VCs Are Usually Seven Years Too Late30:14 Investing: Courage or Luck?42:59-Predictions for 2026 Origins is produced by Sapphire Ventures in partnership with⁠⁠ Pod People.⁠ Nothing presented herein is intended to constitute investment advice, and under no circumstances should any information provided herein be used or considered as an offer to sell or a solicitation of an offer to buy an interest in any investment fund managed by Sapphire Ventures, LLC (“Sapphire”). Any offer or solicitation of securities by Sapphire may only be made in accordance with the current offering documents for a managed Fund in which Sapphire is an advisor. Additionally, Sapphire does not solicit or make its services available to the public; such offerings may only be provided to accredited investors and qualified purchasers defined within the Securities Act of 1933 and the Investment Company Act of 1940. Information provided reflects Sapphire Ventures’ views as of a particular time. Such views are subject to change at any point and Sapphire Ventures shall not be obligated to provide notice of any change. Due to various risks and uncertainties, actual events, results or the actual experience may differ materially from those reflected or contemplated in these statements. While Sapphire Ventures has used reasonable efforts to obtain information from reliable sources, Sapphire makes no representations or warranties as to the accuracy, reliability, or completeness of third party information presented herein. Nothing presented herein may be relied upon as a guarantee or assurance as to the future success of any particular investment opportunity or strategy. Past performance is not indicative of future results.

Origins host Beezer Clarkson,  LP at Sapphire Partners and co-founder of OpenLP, and Nick Chirls, GP at Asylum Ventures, dive into their recent conversation with Kyle Samani, Founder and Managing Partner of Multicoin Capital. They discuss their learnings on crypto, including why Nick is more bullish on bitcoin than Kyle, and how LPs conceptualize investing in firms like Multicoin. They also break down why people who came up as Crypto traders and investors are uniquely positioned to excel in early stage venture. Learn more about Sapphire Partners: sapphireventures.com/sapphire-partners Learn more about OpenLP: openlp.vc Learn more about Asylum Ventures: asylum.vc Learn more about Multicoin: multicoin.capital For a monthly roundup of the latest venture insights, including the newest Origins episodes, subscribe to the OpenLP newsletter – delivered straight to your inbox: subscribe.openlp.vc CHAPTERS: 0:00 Welcome to Origins 1:02 Is Bitcoin an Unproductive Asset? 1:56 The Problem With Web3.0 3:49 Assessing Crypto Managers As an LP 6:21 The Hard Part Isn’t Buying Bitcoin, It’s Holding It 8:21 Trained In Crypto, Excelling In Traditional Markets Origins is produced by Sapphire Ventures in partnership with⁠⁠ Pod People.⁠ Nothing presented herein is intended to constitute investment advice, and under no circumstances should any information provided herein be used or considered as an offer to sell or a solicitation of an offer to buy an interest in any investment fund managed by Sapphire Ventures, LLC (“Sapphire”). Any offer or solicitation of securities by Sapphire may only be made in accordance with the current offering documents for a managed Fund in which Sapphire is an advisor. Additionally, Sapphire does not solicit or make its services available to the public; such offerings may only be provided to accredited investors and qualified purchasers defined within the Securities Act of 1933 and the Investment Company Act of 1940. Information provided reflects Sapphire Ventures’ views as of a particular time. Such views are subject to change at any point and Sapphire Ventures shall not be obligated to provide notice of any change. Due to various risks and uncertainties, actual events, results or the actual experience may differ materially from those reflected or contemplated in these statements. While Sapphire Ventures has used reasonable efforts to obtain information from reliable sources, Sapphire makes no representations or warranties as to the accuracy, reliability, or completeness of third party information presented herein. Nothing presented herein may be relied upon as a guarantee or assurance as to the future success of any particular investment opportunity or strategy. Past performance is not indicative of future results.

Kyle Samani is the Founder and Managing Partner of Multicoin Capital, a thesis-driven investment firm that invests in cryptocurrencies, tokens, and blockchain companies reshaping trillion-dollar markets. He joins Beezer Clarkson, Partner at Sapphire Partners, and Nick Chirls, Partner at Asylum Ventures, to discuss the philosophies that underpin Multicoin’s investment strategies. He also unpacks how blockchain technologies are already reshaping global finance away from legacy systems and towards embedded trading platforms that will sit within traditional messaging and media platforms. Learn more about Sapphire Partners: https://sapphireventures.com/sapphire-partners Learn more about OpenLP: https://openlp.vc Learn more about Asylum Ventures: https://asylum.vc Learn more about Multicoin: https://multicoin.capital Jerry Neumann’s post on markets v. innovation: https://reactionwheel.net/2025/07/a-look-at-growth For a monthly roundup of the latest venture insights, including the newest Origins episodes, subscribe to the OpenLP newsletter – delivered straight to your inbox: subscribe.openlp.vc CHAPTERS: 0:00 Welcome to Origins 2:43 The Origin Story of Multicoin 7:07 Financially Long & Intellectually Short Bitcoin 8:53 What Is an Internet Capital Market? 19:18 What Happens to Banks? 21:14 What Did You See In Solana? 30:22 The Rise of DATs 36:40 Did Web3.0 Live Up To Its Promise? Origins is produced by Sapphire Ventures in partnership with⁠⁠ Pod People.⁠ Nothing presented herein is intended to constitute investment advice, and under no circumstances should any information provided herein be used or considered as an offer to sell or a solicitation of an offer to buy an interest in any investment fund managed by Sapphire Ventures, LLC (“Sapphire”). Any offer or solicitation of securities by Sapphire may only be made in accordance with the current offering documents for a managed Fund in which Sapphire is an advisor. Additionally, Sapphire does not solicit or make its services available to the public; such offerings may only be provided to accredited investors and qualified purchasers defined within the Securities Act of 1933 and the Investment Company Act of 1940. Information provided reflects Sapphire Ventures’ views as of a particular time. Such views are subject to change at any point and Sapphire Ventures shall not be obligated to provide notice of any change. Due to various risks and uncertainties, actual events, results or the actual experience may differ materially from those reflected or contemplated in these statements. While Sapphire Ventures has used reasonable efforts to obtain information from reliable sources, Sapphire makes no representations or warranties as to the accuracy, reliability, or completeness of third party information presented herein. Nothing presented herein may be relied upon as a guarantee or assurance as to the future success of any particular investment opportunity or strategy. Past performance is not indicative of future results.

Origins host Beezer Clarkson,  LP at Sapphire Partners and co-founder of OpenLP, and Nick Chirls, GP at Asylum Ventures, unpack their recent conversation with Sarah Tavel, Partner at Benchmark. Together they discuss their takeaways from Sarah’s recent decision to take a step back at Benchmark to fully focus on AI, getting into the lessons they can learn from that approach and what that means for the future of artificial intelligence. They also discuss the current state of venture in light of this decade’s AI boom, and theorize where this will put the ecosystem in the future. This episode of Origins is supported by Sydecar. Visit https://sydecar.io/origins-podcast to learn more. Learn more about Sapphire Partners: https://sapphireventures.com/sapphire-partners Learn more about OpenLP: https://openlp.vc Learn more about Asylum Ventures: https://asylum.vc Learn more about Benchmark: https://benchmark.com Read Sarah’s Substack Posts: https://sarahtavel.com For a monthly roundup of the latest venture insights, including the newest Origins episodes, subscribe to the OpenLP newsletter – delivered straight to your inbox: https://subscribe.openlp.vc Sydecar, Inc. (“Sydecar”) has acted as a financial sponsor within this Origins podcast. Sapphire Ventures, LLC (“Sapphire”) is not affiliated with or invested in Sydecar. CHAPTERS: 0:00 Welcome to Origins 0:48 How Do We Carve Out More Time For Thinking? 3:02 How Are LPs Handling AI Risk? 6:02 Can You Achieve AI Diversity as an LP? Origins is produced by Sapphire Ventures in partnership with⁠⁠ Pod People.⁠ Nothing presented herein is intended to constitute investment advice, and under no circumstances should any information provided herein be used or considered as an offer to sell or a solicitation of an offer to buy an interest in any investment fund managed by Sapphire Ventures, LLC (“Sapphire”). Any offer or solicitation of securities by Sapphire may only be made in accordance with the current offering documents for a managed Fund in which Sapphire is an advisor. Additionally, Sapphire does not solicit or make its services available to the public; such offerings may only be provided to accredited investors and qualified purchasers defined within the Securities Act of 1933 and the Investment Company Act of 1940. Information provided reflects Sapphire Ventures’ views as of a particular time. Such views are subject to change at any point and Sapphire Ventures shall not be obligated to provide notice of any change. Due to various risks and uncertainties, actual events, results or the actual experience may differ materially from those reflected or contemplated in these statements. While Sapphire Ventures has used reasonable efforts to obtain information from reliable sources, Sapphire makes no representations or warranties as to the accuracy, reliability, or completeness of third party information presented herein. Nothing presented herein may be relied upon as a guarantee or assurance as to the future success of any particular investment opportunity or strategy. Past performance is not indicative of future results.

 Eight years after becoming the first female partner at Benchmark, Sarah Tavel recently took on a new role as Venture Partner that allows her more time to fully immerse herself in AI, all while continuing to make new investments on behalf of Benchmark and serving her current portfolio. She sat down with Beezer Clarkson, Partner at Sapphire Partners, and Nick Chirls, Partner at Asylum Ventures, to unpack her learnings over the past few months, including what it means to be truly AI native, how the future of AI is social (not solo), and what that means for AI tools and the people who use them. She also discusses the importance of protecting your time as a VC and the advantages of devoting time each week to play. This episode of Origins is supported by Sydecar. Visit sydecar.io/origins-podcast to learn more. Learn more about Sapphire Partners: https://sapphireventures.com/sapphire-partners Learn more about OpenLP: https://openlp.vc Learn more about Asylum Ventures: https://asylum.vc Learn more about Benchmark: https://benchmark.com Read Sarah’s Substack Posts: https://sarahtavel.com For a monthly roundup of the latest venture insights, including the newest Origins episodes, subscribe to the OpenLP newsletter – delivered straight to your inbox: https://subscribe.openlp.vc Sydecar, Inc. (“Sydecar”) has acted as a financial sponsor within this Origins podcast. Sapphire Ventures, LLC (“Sapphire”) is not affiliated with or invested in Sydecar. CHAPTERS: 0:00 Welcome to Origins 1:46 Living & Breathing AI 8:58 AI As Both Solo & Social 16:13 What Does It Mean to be AI Native? 23:19 How Do Our Brains Need to Adapt to AI? 31:37 How AI Immersion Has Changed Sarah’s Investment Strategy 37:56 Looking For AI Frontier Companies & the Businesses Around Them Origins is produced by Sapphire Ventures in partnership with⁠⁠ Pod People.⁠ Nothing presented herein is intended to constitute investment advice, and under no circumstances should any information provided herein be used or considered as an offer to sell or a solicitation of an offer to buy an interest in any investment fund managed by Sapphire Ventures, LLC (“Sapphire”). Any offer or solicitation of securities by Sapphire may only be made in accordance with the current offering documents for a managed Fund in which Sapphire is an advisor. Additionally, Sapphire does not solicit or make its services available to the public; such offerings may only be provided to accredited investors and qualified purchasers defined within the Securities Act of 1933 and the Investment Company Act of 1940. Information provided reflects Sapphire Ventures’ views as of a particular time. Such views are subject to change at any point and Sapphire Ventures shall not be obligated to provide notice of any change. Due to various risks and uncertainties, actual events, results or the actual experience may differ materially from those reflected or contemplated in these statements. While Sapphire Ventures has used reasonable efforts to obtain information from reliable sources, Sapphire makes no representations or warranties as to the accuracy, reliability, or completeness of third party information presented herein. Nothing presented herein may be relied upon as a guarantee or assurance as to the future success of any particular investment opportunity or strategy. Past performance is not indicative of future results.

Origins host Beezer Clarkson,  LP at Sapphire Partners and co-founder of OpenLP, and Nick Chirls, GP at Asylum Ventures, dig into their recent conversation with Alex Edelson, LP at Slipstream. They discuss whether a spate of recent 100X multiples means we’re living 2021 all over again, why that’s led people to deploy but not fundraise, and the level of curiosity you need to be an exceptional LP. This episode of Origins is supported by Sydecar. Visit https://sydecar.io/origins-podcast to learn more. Learn more about Sapphire Partners: https://sapphireventures.com/sapphire-partners Learn more about OpenLP: https://openlp.vc Learn more about Asylum Ventures: https://asylum.vc Learn more about Slipstream: https://www.slipstreaminvestors.com/ For a monthly roundup of the latest venture insights, including the newest Origins episodes, subscribe to the OpenLP newsletter – delivered straight to your inbox: https://subscribe.openlp.vc Sydecar, Inc. (“Sydecar”) has acted as a financial sponsor within this Origins podcast. Sapphire Ventures, LLC (“Sapphire”) is not affiliated with or invested in Sydecar. CHAPTERS: 0:00 Welcome to Origins 2:01 Did We Learn Nothing From 2021? 4:09 High Prices, Quick Deployment 6:31 Venture Lives On Bubbles Origins is produced by Sapphire Ventures in partnership with⁠⁠ Pod People.⁠ Nothing presented herein is intended to constitute investment advice, and under no circumstances should any information provided herein be used or considered as an offer to sell or a solicitation of an offer to buy an interest in any investment fund managed by Sapphire Ventures, LLC (“Sapphire”). Any offer or solicitation of securities by Sapphire may only be made in accordance with the current offering documents for a managed Fund in which Sapphire is an advisor. Additionally, Sapphire does not solicit or make its services available to the public; such offerings may only be provided to accredited investors and qualified purchasers defined within the Securities Act of 1933 and the Investment Company Act of 1940. Information provided reflects Sapphire Ventures’ views as of a particular time. Such views are subject to change at any point and Sapphire Ventures shall not be obligated to provide notice of any change. Due to various risks and uncertainties, actual events, results or the actual experience may differ materially from those reflected or contemplated in these statements. While Sapphire Ventures has used reasonable efforts to obtain information from reliable sources, Sapphire makes no representations or warranties as to the accuracy, reliability, or completeness of third party information presented herein. Nothing presented herein may be relied upon as a guarantee or assurance as to the future success of any particular investment opportunity or strategy. Past performance is not indicative of future results.

Alex Edelson’s Slipstream is a fund of funds that focuses on firms that are “difficult to find, evaluate and access.” Together with Beezer Clarkson, Partner at Sapphire Partners, and Nick Chirls, Partner at Asylum Ventures, Alex unpacks his strategy of investing in funds he believes can outperform, how to raise capital as an LP, and how to remain competitive against LPs investing in more established firms. The three of them also dig into a recent blog post by Beezer titled “Is Venture Broken?” - which explores the role of mega-funds in the early-stage market. You can read that here. This episode of Origins is supported by Sydecar. Visit https://sydecar.io/origins-podcast to learn more. Learn more about Sapphire Partners: https://sapphireventures.com/sapphire-partners Learn more about OpenLP: https://openlp.vc⁠ Learn more about Asylum Ventures: https://asylum.vc⁠ Learn more about Slipstream: https://slipstreaminvestors.com For a monthly roundup of the latest venture insights, including the newest Origins episodes, subscribe to the OpenLP newsletter – delivered straight to your inbox: https://subscribe.openlp.vc Sydecar, Inc. (“Sydecar”) has acted as a financial sponsor within this Origins podcast. Sapphire Ventures, LLC (“Sapphire”) is not affiliated with or invested in Sydecar. CHAPTERS: 0:00 Welcome to Origins 2:59 Why Start a Fund of Funds? 7:39 How Do LPs Raise Capital? 16:56 I’m the LP I Wanted to Work With As a GP 21:17 What Is Similar & Different Between Now and 2021? 30:41 What Is an Advantage One Day Is Table Stakes the Next 34:18 You Don’t Need a Big Winner to Have An Amazing Small Fund 39:08 Is Venture Broken? Origins is produced by Sapphire Ventures in partnership with⁠⁠ Pod People.⁠ Nothing presented herein is intended to constitute investment advice, and under no circumstances should any information provided herein be used or considered as an offer to sell or a solicitation of an offer to buy an interest in any investment fund managed by Sapphire Ventures, LLC (“Sapphire”). Any offer or solicitation of securities by Sapphire may only be made in accordance with the current offering documents for a managed Fund in which Sapphire is an advisor. Additionally, Sapphire does not solicit or make its services available to the public; such offerings may only be provided to accredited investors and qualified purchasers defined within the Securities Act of 1933 and the Investment Company Act of 1940. Information provided reflects Sapphire Ventures’ views as of a particular time. Such views are subject to change at any point and Sapphire Ventures shall not be obligated to provide notice of any change. Due to various risks and uncertainties, actual events, results or the actual experience may differ materially from those reflected or contemplated in these statements. While Sapphire Ventures has used reasonable efforts to obtain information from reliable sources, Sapphire makes no representations or warranties as to the accuracy, reliability, or completeness of third party information presented herein. Nothing presented herein may be relied upon as a guarantee or assurance as to the future success of any particular investment opportunity or strategy. Past performance is not indicative of future results.

Origins host Beezer Clarkson,  LP at Sapphire Partners and co-founder of OpenLP is rejoined by Nick Chirls, GP at Asylum Ventures to unpack her recent conversation with Sunil Dhaliwal and Mike Dauber of Amplify Partners. They discuss partner dynamics, the importance of maintaining relevance for the long haul, and the different ways curiosity can show up. Plus, Nick & Beezer dig into whether they count as extroverts at work and introverts everywhere else. Learn more about Sapphire Partners: ⁠https://sapphireventures.com/sapphire-partners⁠ Learn more about OpenLP: ⁠https://openlp.vc⁠ Learn more about Asylum Ventures: ⁠https://asylum.vc Learn more about Amplify: https://amplifypartners.com Subscribe to the OpenLP newsletter for a monthly roundup of the latest venture insights, including the newest Origins episodes, delivered straight to your inbox. CHAPTERS: 0:00 Welcome to Origins 2:18 ”I’m Not Gonna Be a Solo GP Forever” 6:07 Pushing Decision Making to the Edge at Amplify 9:24 How Are You Relevant Five Years From Now? 13:24 Investors: Introverts or Extroverts? Origins is produced by Sapphire Ventures in partnership with⁠⁠ Pod People.⁠ Nothing presented herein is intended to constitute investment advice, and under no circumstances should any information provided herein be used or considered as an offer to sell or a solicitation of an offer to buy an interest in any investment fund managed by Sapphire Ventures, LLC (“Sapphire”). Any offer or solicitation of securities by Sapphire may only be made in accordance with the current offering documents for a managed Fund in which Sapphire is an advisor. Additionally, Sapphire does not solicit or make its services available to the public; such offerings may only be provided to accredited investors and qualified purchasers defined within the Securities Act of 1933 and the Investment Company Act of 1940. Information provided reflects Sapphire Ventures’ views as of a particular time. Such views are subject to change at any point and Sapphire Ventures shall not be obligated to provide notice of any change. Due to various risks and uncertainties, actual events, results or the actual experience may differ materially from those reflected or contemplated in these statements. While Sapphire Ventures has used reasonable efforts to obtain information from reliable sources, Sapphire makes no representations or warranties as to the accuracy, reliability, or completeness of third party information presented herein. Nothing presented herein may be relied upon as a guarantee or assurance as to the future success of any particular investment opportunity or strategy. Past performance is not indicative of future results.

Sunil Dhaliwal founded Amplify in 2012, and was joined by his longtime friend and colleague Mike Dauber in 2014. Beginning as one of the first solo GP, early-stage, sector-focused funds, Amplify has now grown to a team of 9 partners investing in the next generation of applications tools and platforms for developers, data teams, and ML engineers focused on AI, cloud infrastructure, and data security. Mike and Sunil sit down with Beezer Clarkson, Partner at Sapphire Partners, to discuss their strategy of building for outliers, shaping founders into leaders, and making it easy for their GPs to back non-consensus companies. They also unpack their recent $900 million raise and their first dedicated biotech fund, Amplify Bio. Learn more about Sapphire Partners: ⁠https://sapphireventures.com/sapphire-partners⁠ Learn more about OpenLP: ⁠https://openlp.vc⁠ Learn more about Asylum Ventures: ⁠https://asylum.vc Learn more about Amplify: https://amplifypartners.com For a monthly roundup of the latest venture insights, including the newest Origins episodes, subscribe to the OpenLP newsletter – delivered straight to your inbox: subscribe.openlp.vc CHAPTERS: 0:00 Welcome to Origins 2:17 The Origins of Amplify 5:21 Eliminating the Need for “Mr. Business” 10:25 Building Amplify for Outliers 25:08 Being Technical VCs in the Age of AI 28:47 Amplify Bio 36:19 Has Venture Actually Changed At All? Origins is produced by Sapphire Ventures in partnership with⁠⁠ Pod People.⁠ Nothing presented herein is intended to constitute investment advice, and under no circumstances should any information provided herein be used or considered as an offer to sell or a solicitation of an offer to buy an interest in any investment fund managed by Sapphire Ventures, LLC (“Sapphire”). Any offer or solicitation of securities by Sapphire may only be made in accordance with the current offering documents for a managed Fund in which Sapphire is an advisor. Additionally, Sapphire does not solicit or make its services available to the public; such offerings may only be provided to accredited investors and qualified purchasers defined within the Securities Act of 1933 and the Investment Company Act of 1940. Information provided reflects Sapphire Ventures’ views as of a particular time. Such views are subject to change at any point and Sapphire Ventures shall not be obligated to provide notice of any change. Due to various risks and uncertainties, actual events, results or the actual experience may differ materially from those reflected or contemplated in these statements. While Sapphire Ventures has used reasonable efforts to obtain information from reliable sources, Sapphire makes no representations or warranties as to the accuracy, reliability, or completeness of third party information presented herein. Nothing presented herein may be relied upon as a guarantee or assurance as to the future success of any particular investment opportunity or strategy. Past performance is not indicative of future results.

Origins hosts Nick Chirls, GP at Asylum Ventures and Beezer Clarkson,  LP at Sapphire Partners and co-founder of OpenLP, dig into their recent conversation with Will Manidis, SVP at Veradigm AI. They discuss the risks AI introduces to tech incumbents, and its potential to reshape both the healthcare system and improve patient outcomes. Learn more about Sapphire Partners: ⁠https://sapphireventures.com/sapphire-partners⁠ Learn more about OpenLP: ⁠https://openlp.vc⁠ Learn more about Asylum Ventures: ⁠https://asylum.vc Learn more about Veradigm: https://veradigm.com/ Subscribe to the OpenLP newsletter for a monthly roundup of the latest venture insights, including the newest Origins episodes, delivered straight to your inbox. CHAPTERS: 0:00 Welcome to Origins 1:41 Humor in Venture? 3:17 Are Incumbents Finally At Risk? 6:25 How Extremely Online is Nick? Origins is produced by Sapphire Ventures in partnership with⁠⁠ Pod People.⁠ Nothing presented herein is intended to constitute investment advice, and under no circumstances should any information provided herein be used or considered as an offer to sell or a solicitation of an offer to buy an interest in any investment fund managed by Sapphire Ventures, LLC (“Sapphire”). Any offer or solicitation of securities by Sapphire may only be made in accordance with the current offering documents for a managed Fund in which Sapphire is an advisor. Additionally, Sapphire does not solicit or make its services available to the public; such offerings may only be provided to accredited investors and qualified purchasers defined within the Securities Act of 1933 and the Investment Company Act of 1940. Information provided reflects Sapphire Ventures’ views as of a particular time. Such views are subject to change at any point and Sapphire Ventures shall not be obligated to provide notice of any change. Due to various risks and uncertainties, actual events, results or the actual experience may differ materially from those reflected or contemplated in these statements. While Sapphire Ventures has used reasonable efforts to obtain information from reliable sources, Sapphire makes no representations or warranties as to the accuracy, reliability, or completeness of third party information presented herein. Nothing presented herein may be relied upon as a guarantee or assurance as to the future success of any particular investment opportunity or strategy. Past performance is not indicative of future results.

Before he sold his company to Veradigm, Will Manidis’s Science.io developed an AI model that allowed doctors to translate mountains of medical documents into usable data to improve patient outcomes. Today Will is the SVP of AI at Veradigm, and he sits down with Nick and Beezer to discuss how AI is impacting healthcare, how we can develop health systems with better outcomes, and what the future of venture might look like when compared to traditional merchant banking. Learn more about Sapphire Partners: ⁠https://sapphireventures.com/sapphire-partners⁠ Learn more about OpenLP: ⁠https://openlp.vc⁠ Learn more about Asylum Ventures: ⁠https://asylum.vc Learn more about Veradigm: https://veradigm.com/ For a monthly roundup of the latest venture insights, including the newest Origins episodes, subscribe to the OpenLP newsletter – delivered straight to your inbox: https://subscribe.openlp.vc CHAPTERS: 0:00 Welcome to Origins 2:01 Human vs. AI Content (Specifically Podcasts) 6:18 AI And the Future of Healthcare 17:55 Is Merchant Banking Venture’s Future? 25:17 When Does Venture Break? 32:42 “The Only Thing We Should Care About is the Shape of the Return Curve.” 37:24 “The Constraint Is No Longer Capital.” Origins is produced by Sapphire Ventures in partnership with⁠⁠ Pod People.⁠ Nothing presented herein is intended to constitute investment advice, and under no circumstances should any information provided herein be used or considered as an offer to sell or a solicitation of an offer to buy an interest in any investment fund managed by Sapphire Ventures, LLC (“Sapphire”). Any offer or solicitation of securities by Sapphire may only be made in accordance with the current offering documents for a managed Fund in which Sapphire is an advisor. Additionally, Sapphire does not solicit or make its services available to the public; such offerings may only be provided to accredited investors and qualified purchasers defined within the Securities Act of 1933 and the Investment Company Act of 1940. Information provided reflects Sapphire Ventures’ views as of a particular time. Such views are subject to change at any point and Sapphire Ventures shall not be obligated to provide notice of any change. Due to various risks and uncertainties, actual events, results or the actual experience may differ materially from those reflected or contemplated in these statements. While Sapphire Ventures has used reasonable efforts to obtain information from reliable sources, Sapphire makes no representations or warranties as to the accuracy, reliability, or completeness of third party information presented herein. Nothing presented herein may be relied upon as a guarantee or assurance as to the future success of any particular investment opportunity or strategy. Past performance is not indicative of future results.

Origins hosts Nick Chirls, GP at Asylum Ventures and Beezer Clarkson,  LP at Sapphire Partners and co-founder of OpenLP, unpack their conversation with Zach Weinberg, Co-Founder and CEO of Curie.Bio. They discuss the “innovation energy” that drives new breakthroughs and take a closer look at Sapphire’s approach to biotech investing. Learn more about Sapphire Partners: ⁠https://sapphireventures.com/sapphire-partners⁠ Learn more about OpenLP: ⁠https://openlp.vc⁠ Learn more about Asylum Ventures: ⁠https://asylum.vc Learn more about Curie.Bio: https://curie.bio Subscribe to the OpenLP newsletter for a monthly roundup of the latest venture insights, including the newest Origins episodes, delivered straight to your inbox. CHAPTERS: 0:00 Welcome to Origins 1:28 Building Something That Wouldn’t Exist Otherwise 4:27 What’s Sapphire Doing in BioTech? 8:38 The Market & BioTech 10:05 "Vitamin O" Origins is produced by Sapphire Ventures in partnership with⁠⁠ Pod People.⁠ Nothing presented herein is intended to constitute investment advice, and under no circumstances should any information provided herein be used or considered as an offer to sell or a solicitation of an offer to buy an interest in any investment fund managed by Sapphire Ventures, LLC (“Sapphire”). Any offer or solicitation of securities by Sapphire may only be made in accordance with the current offering documents for a managed Fund in which Sapphire is an advisor. Additionally, Sapphire does not solicit or make its services available to the public; such offerings may only be provided to accredited investors and qualified purchasers defined within the Securities Act of 1933 and the Investment Company Act of 1940. Information provided reflects Sapphire Ventures’ views as of a particular time. Such views are subject to change at any point and Sapphire Ventures shall not be obligated to provide notice of any change. Due to various risks and uncertainties, actual events, results or the actual experience may differ materially from those reflected or contemplated in these statements. While Sapphire Ventures has used reasonable efforts to obtain information from reliable sources, Sapphire makes no representations or warranties as to the accuracy, reliability, or completeness of third party information presented herein. Nothing presented herein may be relied upon as a guarantee or assurance as to the future success of any particular investment opportunity or strategy. Past performance is not indicative of future results.

Zach Weinberg, co-founder and CEO of Curie.Bio, is redefining early-stage biotech investing with an operator’s mindset and a founder-first philosophy. His approach combines funding with operational support and direct access to world-class drug hunters to dramatically increase odds of success. Today, Zach sits down with Nick Chirls, GP at Asylum Ventures and Beezer Clarkson,  LP at Sapphire Partners to discuss the massive risk associated with traditional therapeutics startups, how pairing a drug discovery partner with a seed investor solves those inefficiencies, and how biotech, the global economy and the political landscape are all closely connected. Learn more about Sapphire Partners: ⁠https://sapphireventures.com/sapphire-partners⁠ Learn more about OpenLP: ⁠https://openlp.vc⁠ Learn more about Asylum Ventures: ⁠https://asylum.vc Learn more about Curie.Bio: https://curie.bio For a monthly roundup of the latest venture insights, including the newest Origins episodes, subscribe to the OpenLP newsletter – delivered straight to your inbox: https://subscribe.openlp.vc CHAPTERS: 0:00 Welcome to Origins 5:08 Was Hunter High School Harder Than Penn? 10:22 Transitioning From SaaS to Biotech 20:55 Why Is Building a Biotech Venture Firm So Hard? 27:55 Building Curie.Bio 32:24 Zach on Drug Discovery 43:12 Biotech in China 49:42 AI in Biotech 54:51 "The Manhattan Project of Biology" Origins is produced by Sapphire Ventures in partnership with⁠⁠ Pod People.⁠ Nothing presented herein is intended to constitute investment advice, and under no circumstances should any information provided herein be used or considered as an offer to sell or a solicitation of an offer to buy an interest in any investment fund managed by Sapphire Ventures, LLC (“Sapphire”). Any offer or solicitation of securities by Sapphire may only be made in accordance with the current offering documents for a managed Fund in which Sapphire is an advisor. Additionally, Sapphire does not solicit or make its services available to the public; such offerings may only be provided to accredited investors and qualified purchasers defined within the Securities Act of 1933 and the Investment Company Act of 1940. Information provided reflects Sapphire Ventures’ views as of a particular time. Such views are subject to change at any point and Sapphire Ventures shall not be obligated to provide notice of any change. Due to various risks and uncertainties, actual events, results or the actual experience may differ materially from those reflected or contemplated in these statements. While Sapphire Ventures has used reasonable efforts to obtain information from reliable sources, Sapphire makes no representations or warranties as to the accuracy, reliability, or completeness of third party information presented herein. Nothing presented herein may be relied upon as a guarantee or assurance as to the future success of any particular investment opportunity or strategy. Past performance is not indicative of future results.