
Advertise on podcast: Gladden Longevity Podcast
Rating
4.6from
This podcast has
361 episodes
Language
EnglishPublisher
Gladden Longevity PodcastExplicit
No
Date created
2017/11/29
Latest episode
2026/10/22
Average duration
39 min.
Release period
8 days
Description
On this podcast focused on health and human longevity, Dr. Jeffrey R. Gladden, MD, FACC, examine the latest scientific research, technology, and biohacks to uncover the truth about the human body's potential for extending both life and health span well past what most people accept as biological facts.
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From Illness to Insight: Stephen's Health Journey - Episode 361
2026/10/22
Stephen Hussey shares his remarkable health journey, detailing his struggles with various inflammatory conditions from a young age, including asthma and type one diabetes. He discusses how lifestyle changes, particularly in diet, played a crucial role in managing his health. Despite leading a healthy lifestyle, Stephen experienced a widowmaker heart attack at the age of 34, which he describes in detail, including the symptoms and recovery process. He also explores the limitations of traditional medicine in predicting heart health risks and shares his decision to pursue alternative therapies post-heart attack, including the use of infrared sauna therapy. In this conversation, Dr. Gladden and Stephen Hussey explore the transformative journey of healing post-heart attack, emphasizing the importance of lifestyle changes, dietary adjustments, and the role of structured water in maintaining heart health. They discuss the significance of nitric oxide, the glycocalyx, and how structured water can enhance bodily functions. Stephen shares practical daily routines for optimizing structured water and the benefits of energized water, providing insights into how individuals can improve their health through natural means.
For Audience
Join the other 20,000+ high-performers getting weekly insights on biological reversal, exponential strategies, and Life Energy optimization→ https://start.gladdenlongevity.com/subscribe
If you're ready to measure your 60+ biological ages and build a personalized reversal plan, apply for a discovery call here → https://start.gladdenlongevity.com/apply-now
Use code 'Podcast10' to get 10% OFF on any of our supplements at https://gladdenlongevityshop.com/!
Takeaways
· Stephen had multiple inflammatory conditions from a young age.
· Diet changes significantly improved Stephen's health.
· He pursued a career in chiropractic and nutrition after college.
· Despite a healthy lifestyle, Stephen suffered a heart attack at 34.
· Traditional medicine often fails to predict heart attack risks.
· Stephen's heart attack was caused by an occluded artery.
· He recovered well after the heart attack with minimal damage.
· Stephen chose not to take certain medications post-heart attack.
· He utilized infrared sauna therapy for heart health.
· Lifestyle choices played a crucial role in Stephen's recovery. Stephen Hussey emphasizes the importance of a low-carb, animal-based diet post-heart attack.
· Infrared sauna and sunlight exposure were key changes in Stephen's healing process.
· Nitric oxide plays a crucial role in arterial health and healing.
· The glycocalyx is essential for preventing plaque formation in arteries.
· Structured water is vital for maintaining a healthy cardiovascular system.
· Structured water creates a frictionless surface for blood flow.
· Energy from the sun is crucial for building structured water in the body.
· Daily practices can enhance structured water, even in winter.
· Grounding and contact with the earth are important for health.
· Energized water can be beneficial if it is toxin-free and mineral-rich.
Chapters
00:00 Stephen's Health Journey: From Childhood Illness to Heart Attack
08:53 The Heart Attack Experience: Insights and Recovery
16:52 Post-Heart Attack Choices: Alternative Therapies and Lifestyle Changes
18:25 Healing Journey: Lifestyle Changes Post-Heart Attack
21:04 The Role of Nitric Oxide and Glycocalyx in Heart Health
23:59 Understanding Structured Water and Its Importance
28:58 Daily Practices for Optimizing Structured Water
34:09 The Science of Energized Water and Its Benefits
To learn more about Dr. Stephen Hussey:
Website: www.resourceyourhealth.com
IG, FB, X, YT: @drstephenhussey
Reach out to us at:
Website: https://gladdenlongevity.com/
Facebook: https://www.facebook.com/Gladdenlongevity/
Instagram: https://www.instagram.com/gladdenlongevity/?hl=en
LinkedIn: https://www.linkedin.com/company/gladdenlongevity
YouTube: https://www.youtube.com/channel/UC5_q8nexY4K5ilgFnKm7naw
Age Reversal, Cryonics, and the Biology of Life Extension - Episode 360
2026/10/15
Dr. Gladden and Dr. Max More delve into the realms of transhumanism, life extension, and the philosophy of extropy. They explore the concept of cryonics and biostasis as potential solutions for achieving longevity, while also discussing the societal implications of AI and the search for meaning in an extended life. The dialogue emphasizes the importance of community, personal growth, and the challenges faced in the pursuit of a longer, healthier life. In this conversation, Dr. Gladden and Max More delve into the fascinating realms of age reversal, longevity practices, and the science of cryonics. They discuss the importance of diet, exercise, and sleep in maintaining health, while also addressing common misconceptions about cryonics. The conversation explores the techniques used in cryopreservation, the significance of memory retention, and the advancements in cooling methods that could revolutionize the field. Ultimately, they present a hopeful vision for the future of medicine and preservation.
For Audience
Join the other 20,000+ high-performers getting weekly insights on biological reversal, exponential strategies, and Life Energy optimization→ https://start.gladdenlongevity.com/subscribe
If you're ready to measure your 60+ biological ages and build a personalized reversal plan, apply for a discovery call here → https://start.gladdenlongevity.com/apply-now
Use code 'Podcast10' to get 10% OFF on any of our supplements at https://gladdenlongevityshop.com/!
Takeaways
· Max More's interest in health began at a young age.
· Life extension and biostasis are seen as viable options.
· The definition of death is becoming increasingly complex.
· Cryonics aims to preserve the brain's ultrastructure.
· The philosophy of extropy encourages questioning limits.
· AI's impact on work and society is a topic of concern.
· Finding meaning in life is crucial for longevity.
· Engagement in creative pursuits enhances life satisfaction.
· Challenges are necessary for personal growth.
· The Trim Trials show promising results in immune system rejuvenation. Age reversal techniques can yield significant results.
· Maintaining a healthy lifestyle is crucial for longevity.
· Cryonics is accessible and not just for the wealthy.
· Preservation methods are based on scientific principles.
· Memory retention in cryopreservation is a key area of research.
· Rapid cooling techniques can enhance preservation outcomes.
· Education about cryonics can dispel myths and misconceptions.
· The future of medicine may include advanced preservation methods.
· Understanding the science behind cryonics is essential for informed decisions.
· Taking care of one's health is vital for optimal preservation.
Chapters
00:00 Introduction to Transhumanism and Life Extension
03:06 Exploring Cryonics and Biostasis
05:58 Philosophy of Extropy and Human Improvement
09:08 The Role of AI and Future Work
11:50 Finding Meaning and Purpose in Longevity
15:01 Community and Collaboration in Transhumanism
18:02 Challenges and Personal Growth in Longevity Research
21:49 Exploring Age Reversal Techniques
23:33 Foundations of Longevity: Diet, Exercise, and Sleep
25:23 Understanding Cryonics: Myths and Realities
27:58 The Science of Preservation: Techniques and Evidence
31:07 Memory and Consciousness: Insights from Cryopreservation
34:05 Rapid Cooling Techniques in Medicine
39:11 The Future of Cryonics: A New Perspective
To learn more about Dr. Max More:
Website: https://www.maxmore.com/
Reach out to us at:
Website: https://gladdenlongevity.com/
Facebook: https://www.facebook.com/Gladdenlongevity/
Instagram: https://www.instagram.com/gladdenlongevity/?hl=en
LinkedIn: https://www.linkedin.com/company/gladdenlongevity
YouTube: https://www.youtube.com/channel/UC5_q8nexY4K5ilgFnKm7naw
The Science Behind Aging and Rejuvenation - Episode 359
2026/10/08
In this conversation, Dr. Gladden and Aubrey de Grey discuss the rapid advancements in the field of longevity research, emphasizing the importance of a systems biology approach to understanding aging. They explore the uneven distribution of funding and interest in various areas of research, the role of basic science, and the potential of stem cell therapies. The discussion highlights the need for a comprehensive strategy in addressing aging and the promising results from recent mouse trials. In this conversation, Aubrey de Grey discusses innovative approaches to senolytics and therapeutic combinations aimed at extending human lifespan. He emphasizes the importance of funding and research priorities in longevity, the role of AI in aging research, and the need to mobilize society against aging, drawing parallels to the COVID-19 pandemic. De Grey also elaborates on the hallmarks of aging and their implications for future research, while sharing his personal longevity strategies and practices.
For Audience
Join the other 20,000+ high-performers getting weekly insights on biological reversal, exponential strategies, and Life Energy optimization→ https://start.gladdenlongevity.com/subscribe
If you're ready to measure your 60+ biological ages and build a personalized reversal plan, apply for a discovery call here → https://start.gladdenlongevity.com/apply-now
Use code 'Podcast10' to get 10% OFF on any of our supplements at https://gladdenlongevityshop.com/!
Takeaways
· The longevity field is advancing rapidly with increased funding.
· Interest in aging research is unevenly distributed.
· A systems biology approach is essential for understanding aging.
· Basic science is critical for developing effective interventions.
· Stem cell therapies show promise in treating age-related diseases.
· Rejuvenation should be viewed as an ongoing process.
· Combining multiple interventions may yield better results.
· Personalization of treatments is crucial for effectiveness.
· Understanding the body's responses can lead to better outcomes.
· Future trials will explore a wider range of interventions. We're using a vitaclax that is no longer toxic to platelets.
· The new senolytic from Rockfish Bio shows promising results.
· Our choices are focused on maximizing knowledge per dollar.
· There's a lack of funding for comprehensive aging studies.
· AI can provide insights but cannot replace clinical trials.
· Mobilizing society is crucial to take aging seriously.
· The hallmarks of aging classify downstream effects of damage.
· Repairing damage is more effective than understanding its mechanisms.
· Maintaining youthfulness is an ongoing process.
· Regular health check-ups can identify personal weak links.
Chapters
00:00 The Current State of Longevity Research
02:50 The Systems Biology Approach to Aging
06:02 Understanding Aging: A Systems Perspective
08:56 The Role of Basic Science in Longevity
11:58 Interventions in Aging: Current Progress
14:56 The Future of Stem Cell Therapies
18:08 Rejuvenation as a Process
21:01 The Divide and Conquer Strategy in Aging Research
23:52 The Next Steps in Mouse Trials
29:15 Innovative Approaches to Senolytics
31:02 Exploring New Therapeutic Combinations
32:36 Funding and Research Priorities in Longevity
33:09 The Role of AI in Aging Research
34:28 Mobilizing Society Against Aging
39:26 The Hallmarks of Aging and Their Implications
51:12 Personal Longevity Strategies and Practices
To learn more about Dr. Aubrey De Grey:
Website: https://www.levf.org/
Reach out to us at:
Website: https://gladdenlongevity.com/
Facebook: https://www.facebook.com/Gladdenlongevity/
Instagram: https://www.instagram.com/gladdenlongevity/?hl=en
LinkedIn: https://www.linkedin.com/company/gladdenlongevity
YouTube: https://www.youtube.com/channel/UC5_q8nexY4K5ilgFnKm7naw
Mastering Memory Techniques with Ron White - Episode 358
2026/10/01
In this episode of the Gladden Longevity Podcast, Dr. Gladden interviews memory expert and 2x USA Memory Champion, Ron White, who shares his journey into memory training and the techniques he uses to enhance memory. They discuss the mechanics of memory, the importance of repetition and review, and practical strategies for remembering names and information. Ron emphasizes the role of health, nutrition, and exercise in memory function and introduces the Mind Palace technique as a powerful tool for memory enhancement. In this conversation, Ron White discusses various memory techniques, particularly the mind palace method, and how he applies these strategies in memory competitions. He emphasizes the importance of visualization, emotional engagement, and understanding in the memorization process. The discussion also covers his preparation for the upcoming National Memory Championship, where he will face various challenges that test his memory skills. Throughout the conversation, the significance of making learning enjoyable and meaningful is highlighted.
For Audience
Join the other 20,000+ high-performers getting weekly insights on biological reversal, exponential strategies, and Life Energy optimization→ https://start.gladdenlongevity.com/subscribe
If you're ready to measure your 60+ biological ages and build a personalized reversal plan, apply for a discovery call here → https://start.gladdenlongevity.com/apply-now
Use code 'Podcast10' to get 10% OFF on any of our supplements at https://gladdenlongevityshop.com/!
Takeaways
· Memory is not a gift; anyone can improve it.
· Repetition is crucial for memory retention.
· The forgetting curve shows how quickly we forget without review.
· Recognizing information is the first step to recalling it.
· Vivid and detailed mental images enhance memory.
· Good nutrition and exercise support cognitive health.
· Hearing impairment can affect memory and cognitive function.
· Engaging all senses can improve memory retention.
· The Mind Palace technique helps organize and recall information.
· Creating stories around names can aid in remembering them. The mind palace technique allows for effective memorization.
· Visualization enhances memory retention and understanding.
· Emotional engagement can significantly improve memory recall.
· Memory techniques can be applied in various contexts, including competitions.
· Understanding the material is as important as memorizing it.
· Creating associations can help in remembering complex information.
· Repetition and review are crucial for long-term memory retention.
· Using humor and creativity can aid in the memorization process.
· Memory competitions test not only memory but also strategy and preparation.
· Approaching memory challenges as a game can make the process more enjoyable.
Chapters
00:00 Introduction to Memory Mastery
02:03 The Journey into Memory Training
05:50 Understanding Memory Mechanics
12:13 Practical Memory Techniques
17:52 The Role of Health in Memory
22:03 Exploring the Mind Palace Technique
26:51 The Mind Palace Technique
31:46 Memory Techniques for Competitions
36:39 Visualization and Understanding in Memory
40:49 Preparing for the National Memory Championship
46:00 The Emotional Aspect of Memory
To learn more about Ron White:
Website: https://ronwhitetraining.com/
Reach out to us at:
Website: https://gladdenlongevity.com/
Facebook: https://www.facebook.com/Gladdenlongevity/
Instagram: https://www.instagram.com/gladdenlongevity/?hl=en
LinkedIn: https://www.linkedin.com/company/gladdenlongevity
YouTube: https://www.youtube.com/channel/UC5_q8nexY4K5ilgFnKm7naw
The Metabolic Approach to Psychiatry - Episode 357
2026/09/17
In this episode, Dr. Jeffrey Gladden and psychiatrist Dr. Matt Bernstein discuss the evolving landscape of mental health treatment. Bernstein shares his extensive experience in psychiatry, particularly with serious mental health conditions, and highlights the limitations of traditional medication approaches. He advocates for a more holistic view that considers metabolic health and mitochondrial function as critical components in understanding and treating mental health issues. The conversation also delves into the benefits of the ketogenic diet, cognitive flexibility, and the complexities of medication management in psychiatric care. In this conversation, Dr. Gladden and Matt Bernstein explore the intricate relationship between mental health, metabolism, exercise, and the role of psychedelics in therapy. They discuss the negative metabolic impacts of psychotropic medications, the significant benefits of exercise for mental health, and the importance of understanding individual genetics in managing depression. The conversation also delves into the role of lactate in brain health, mitochondrial function, and the potential of psychedelic therapies for personal transformation. Ultimately, they emphasize the need for a holistic approach to health that encompasses physical, mental, and spiritual well-being.
For Audience
Join the other 20,000+ high-performers getting weekly insights on biological reversal, exponential strategies, and Life Energy optimization→ https://start.gladdenlongevity.com/subscribe
If you're ready to measure your 60+ biological ages and build a personalized reversal plan, apply for a discovery call here → https://start.gladdenlongevity.com/apply-now
Use code 'Podcast10' to get 10% OFF on any of our supplements at https://gladdenlongevityshop.com/!
Takeaways
· Matt Bernstein has 26 years of experience in psychiatry.
· He works with serious mental health conditions like bipolar disorder and schizophrenia.
· Traditional psychiatric medications often lead to metabolic and neurological side effects.
· Anhedonia is a significant issue in mental health, meaning a lack of pleasure.
· There is a need for a fresh perspective on mental health rooted in metabolism.
· Mitochondrial dysfunction is linked to serious mental illnesses.
· The ketogenic diet can be an effective intervention for mental health.
· Cognitive flexibility is crucial for managing mental health conditions.
· Medication management is complex and requires careful consideration.
· Not all patients can or should stop their medications completely. Psychotropic medications can negatively impact metabolic health.
· Exercise has a greater effect on depression than antidepressants.
· Intense exercise is crucial for mental health benefits.
· Genetics play a significant role in individual responses to depression.
· Lactate production during exercise is beneficial for brain health.
· Mitochondrial health is essential for longevity and mental well-being.
· Stress affects both neurological and hormonal health.
· Psychedelic therapies can provide transformative experiences for some individuals.
· Social connectedness and purpose are vital for longevity.
· Holistic approaches to health should integrate physical, mental, and spiritual aspects.
Chapters
00:00 Introduction to Mental Health Perspectives
02:58 The Limitations of Traditional Psychiatry
05:54 Exploring Root Causes in Mental Health
09:05 The Role of Metabolism and Mitochondrial Function
11:54 The Ketogenic Diet as a Therapeutic Approach
14:59 Cognitive Flexibility and Mental Health
17:56 Medication Management in Psychiatric Care
23:24 Impact of Psychotropics on Metabolism
24:49 The Role of Exercise in Mental Health
27:53 Genetics and Personal Insights on Depression
29:32 Lactate Production and Brain Health
32:46 Mitochondrial Health and Longevity
36:30 Mind-Body Connection and Stress Management
39:08 Psychedelic-Assisted Therapies
45:07 Optimizing Longevity and Health Span
To learn more about Dr. Matt Bernstein:
Website: www.accordmh.com
LinkedIn: www.linkedin.com/in/mattbernsteinmd
Reach out to us at:
Website: https://gladdenlongevity.com/
Facebook: https://www.facebook.com/Gladdenlongevity/
Instagram: https://www.instagram.com/gladdenlongevity/?hl=en
LinkedIn: https://www.linkedin.com/company/gladdenlongevity
YouTube: https://www.youtube.com/channel/UC5_q8nexY4K5ilgFnKm7naw
Dr. Jeffrey Gladden's Daily Longevity Routine: How He Trains for Strength, Mobility, and Energy - Episode 356
2026/09/10
Dr. Jeffrey Gladden shares the full routine he uses to support longevity day to day, from his first hour in the morning to his weekly, monthly, and yearly training priorities. The episode is useful if you want a practical look at how he combines recovery, movement, therapy, and mindset to stay active and sharp.
For Audience
Join the other 20,000+ high-performers getting weekly insights on biological reversal, exponential strategies, and Life Energy optimization→ https://start.gladdenlongevity.com/subscribe
If you're ready to measure your 60+ biological ages and build a personalized reversal plan, apply for a discovery call here → https://start.gladdenlongevity.com/apply-now
Use code 'Podcast10' to get 10% OFF on any of our supplements at https://gladdenlongevityshop.com/!
Takeaways
In this episode, Dr. Gladden explains why he never wakes up to an alarm and instead lets his body set his sleep schedule. He starts his day with thyroid medication, then uses the first 30 minutes for journaling, gratitude, daily goals, and affirmations. He describes music as part of his routine, including picking up the guitar each morning to write, doodle, and release emotional energy. He rotates his exercise instead of repeating the same workout daily, using mountain biking, running, elliptical work, and an elevation training mask to build lung capacity. He emphasizes getting outside as often as possible and treating movement as a daily non-negotiable. He stacks cardio with sauna when possible, often doing both before starting work. He does not begin his workday until 10 a.m., using the morning to train, recover, and mentally prepare for clients and emails. He trains mobility as seriously as cardio and resistance work, including floor work, crawling, burpees, and deep squat practice. He mentions monthly therapies such as plasmapheresis, Eboo, red light, and ozone sauna as part of his longer-cycle routine. He frames longevity as a yearly performance target: stronger, faster, fitter, sharper, and more mobile than the year before. He stresses treating injuries immediately and using regenerative therapies and peptides to reduce downtime and slow the acceleration of aging. He believes many people stop short in training and need to lean into hard effort rather than backing off too early.
Chapters
00:00 - Dr. Jeffrey Gladden's longevity philosophy and "100 is the new 30"
00:34 - Waking without an alarm and starting with thyroid medication
01:04 - Journaling, gratitude, goals, and affirmations to center the day
01:32 - Guitar, songwriting, and creative release as part of the morning
01:58 - Rotating cardio: mountain biking, running, elliptico, and lung capacity work
02:21 - Stacking sauna with cardio and why he delays the workday until 10 a.m.
02:57 - Why self-care comes before work performance
03:25 - Weekly training: resistance work, balance, crawling, burpees, and deep squats
03:54 - Building mobility through floor-based movement and outdoor activity
04:18 - Monthly therapies: plasmapheresis, Eboo, red light, and ozone sauna
04:54 - The yearly goal: outperform last year and treat injuries immediately
05:24 - Why aging requires different training strategies, including peptides
05:49 - Leaning into difficult workouts instead of backing off too early
06:19 - VO2 max testing, progress tracking, and listener call to action
Reach out to us at:
Website: https://gladdenlongevity.com/
Facebook: https://www.facebook.com/Gladdenlongevity/
Instagram: https://www.instagram.com/gladdenlongevity/?hl=en
LinkedIn: https://www.linkedin.com/company/gladdenlongevity
YouTube: https://www.youtube.com/channel/UC5_q8nexY4K5ilgFnKm7naw
Navigating the World of 503A and 503B Pharmacies - Episode 355
2026/09/03
In this episode of the Gladden Longevity Podcast, Dr. Gladden hosts Joshua Fritzler, President of Olympia Pharmaceuticals, and Nicole Snow to discuss the intricacies of compounding pharmacies, focusing on the differences between 503A and 503B pharmacies, the role of compounding in personalized medicine, and the current landscape of peptides and FDA oversight. The conversation highlights the importance of safety, regulation, and quality assurance in compounded medications, providing listeners with a comprehensive understanding of how these pharmacies operate and their significance in modern healthcare.
For Audience
Join the other 20,000+ high-performers getting weekly insights on biological reversal, exponential strategies, and Life Energy optimization→ https://start.gladdenlongevity.com/subscribe
If you're ready to measure your 60+ biological ages and build a personalized reversal plan, apply for a discovery call here → https://start.gladdenlongevity.com/apply-now
Use code 'Podcast10' to get 10% OFF on any of our supplements at https://gladdenlongevityshop.com/!
Takeaways
· Compounding pharmacies create personalized medications not commercially available.
· 503A pharmacies serve individual patients with specific prescriptions.
· 503B pharmacies produce larger batches for clinics and have stricter regulations.
· Compounded medications can be tailored to avoid allergens or intolerances.
· FDA does not approve compounded medications, but regulates the pharmacies.
· Safety profiles of compounded medications are generally high when produced correctly.
· Patients can request specific formulations that are not available commercially.
· Compounding pharmacies must comply with state and federal regulations.
· Quality assurance is critical in compounding, including testing for potency.
· Understanding the differences between compounding pharmacies is essential for patients.
Chapters
00:00 Introduction to Compounding Pharmacies
02:55 Understanding 503A and 503B Pharmacies
05:56 The Role of Compounding in Personalized Medicine
08:52 Safety and Regulation of Compounded Medications
11:54 Differences Between 503A and 503B Pharmacies
14:52 Navigating Prescription and State Regulations
17:50 The Current Landscape of Peptides and FDA Oversight
24:03 Quality Assurance in Compounding Pharmacies
27:55 Conclusion and Future Directions
55:52 A Call for a Manhattan Project in Chronic Disease Research
To learn more about Joshua:
Email: [email protected]
Website: http://olympiapharmacy.com
LinkedIn: https://www.linkedin.com/in/joshuafritzler/
Reach out to us at:
Website: https://gladdenlongevity.com/
Facebook: https://www.facebook.com/Gladdenlongevity/
Instagram: https://www.instagram.com/gladdenlongevity/?hl=en
LinkedIn: https://www.linkedin.com/company/gladdenlongevity
YouTube: https://www.youtube.com/channel/UC5_q8nexY4K5ilgFnKm7naw
Preventing Heart Disease: A New Paradigm - Episode 354
2026/08/27
In this conversation, Dr. Jeffrey Gladden and Dr. Philip Ovadia discuss the critical intersection of cardiology and longevity, emphasizing the need for a shift from treating heart disease to preventing it. They explore personal transformations, the role of diet, particularly low-carb and carnivore diets, and the importance of understanding insulin resistance in relation to heart health. The discussion also highlights advancements in cardiovascular diagnostics and the necessity for early detection and patient education to combat heart disease effectively.
For Audience
Join the other 20,000+ high-performers getting weekly insights on biological reversal, exponential strategies, and Life Energy optimization→ https://start.gladdenlongevity.com/subscribe
If you're ready to measure your 60+ biological ages and build a personalized reversal plan, apply for a discovery call here → https://start.gladdenlongevity.com/apply-now
Use code 'Podcast10' to get 10% OFF on any of our supplements at https://gladdenlongevityshop.com/!
Takeaways
· The focus on longevity in cardiology is essential.
· Preventing heart disease is more effective than treating it.
· Personal health transformations can lead to professional insights.
· Dietary changes can significantly impact heart health.
· Insulin resistance is a major factor in heart disease.
· Understanding the role of cholesterol is crucial.
· Early detection of insulin resistance can prevent heart disease.
· Patient education is vital for long-term health outcomes.
· Innovative diagnostics can revolutionize heart disease management.
· A holistic approach to rehabilitation is necessary for recovery.
Chapters
00:00 Introduction to Longevity in Cardiology
02:50 The Shift from Treatment to Prevention
05:59 Personal Transformation and Dietary Changes
08:58 Understanding Insulin Resistance and Heart Disease
12:02 The Role of Diet in Cardiovascular Health
15:07 Innovations in Cardiovascular Diagnostics
18:02 The Importance of Early Detection
20:56 Rehabilitation and Patient Education
24:07 The Future of Cardiology and Preventative Care
To learn more about Dr. Philip Ovadia:
Facebook: https://www.facebook.com/ovadiahearthealth
Instagram: https://www.instagram.com/ifixhearts/
Twitter: https://twitter.com/ifixhearts
X URL: https://x.com/ifixhearts
YouTube: https://www.youtube.com/@IFixHearts
LinkedIn: Linkedin.com/in/philip-ovadia-heart-health/
Book: https://www.amazon.com/Stay-off-Operating-Table-Metabolic/dp/1737818205/
Reach out to us at:
Website: https://gladdenlongevity.com/
Facebook: https://www.facebook.com/Gladdenlongevity/
Instagram: https://www.instagram.com/gladdenlongevity/?hl=en
LinkedIn: https://www.linkedin.com/company/gladdenlongevity
YouTube: https://www.youtube.com/channel/UC5_q8nexY4K5ilgFnKm7naw
Gladden Longevity Podcast Disclosures
Production & Independence The Gladden Longevity Podcast and Age Hackers are produced by Gladden Longevity Podcast, which operates independently from Dr. Jeffrey Gladden's clinical practice and research at Gladden Longevity in Irving, Texas.
Dr. Gladden may serve as a founder, advisor, or investor in select health, wellness, or longevity-related ventures. These may occasionally be referenced in podcast discussions when relevant to educational topics. Any such mentions are for informational purposes only and do not constitute endorsements.
Medical Disclaimer The Gladden Longevity Podcast is intended for educational and informational purposes only. It does not constitute the practice of medicine, nursing, or other professional healthcare services — including the giving of medical advice — and no doctor–patient relationship is formed through this podcast or its associated content.
The information shared on this podcast, including opinions, research discussions, and referenced materials, is not intended to replace or serve as a substitute for professional medical advice, diagnosis, or treatment. Listeners should not disregard or delay seeking medical advice for any condition they may have. Always seek the guidance of a qualified healthcare professional regarding any questions or concerns about your health, medical conditions, or treatment options.
Use of information from this podcast and any linked materials is at the listener's own risk.
Podcast Guest Disclosures Guests on the Gladden Longevity Podcast may hold financial interests, advisory roles, or ownership stakes in companies, products, or services discussed during their appearance. The views expressed by guests are their own and do not necessarily reflect the opinions or positions of Gladden Longevity, Dr. Jeffrey Gladden, or the production team.
Sponsorships & Affiliate Disclosures To support the creation of high-quality educational content, the Gladden Longevity Podcast may include paid sponsorships or affiliate partnerships. Any such partnerships will be clearly identified during episodes or noted in the accompanying show notes.
We may receive compensation through affiliate links or sponsorship agreements when products or services are mentioned on the show. However, these partnerships do not influence the opinions, recommendations, or clinical integrity of the information presented.
Additional Note on Content Integrity All content is carefully curated to align with our mission of promoting science-based, ethical, and responsible approaches to health, wellness, and longevity. We strive to maintain the highest standards of transparency and educational value in all our communications.
Unraveling Alzheimer's: The Pathobiome Connection - Episode 353
2026/08/20
Dr. Gladden and Nikki Schultek explore the intricate links between Alzheimer's disease, infections, and the pathobiome. Nikki shares her personal journey through chronic illness and how it led her to advocate for a better understanding of the role of infections in autoimmune and neurodegenerative diseases. They discuss the importance of a systems biology approach to healthcare, emphasizing the need for collaboration among specialists to address complex health issues. The conversation highlights the interplay between genetics, infections, and chronic diseases, and the potential for future research to uncover new treatment avenues. In this conversation, Dr. Gladden and Nikki Schultek discuss the integration of systems biology in health optimization, emphasizing the importance of collaboration in research and the role of AI in uncovering health insights. They explore the microbiome's impact on neurodegenerative diseases, hormonal influences on aging, and the necessity of a strong therapeutic connection in patient care. The discussion also touches on economic incentives in healthcare and the urgent need for a comprehensive approach to chronic disease research, likening it to a Manhattan Project.
For Audience
Join the other 20,000+ high-performers getting weekly insights on biological reversal, exponential strategies, and Life Energy optimization→ https://start.gladdenlongevity.com/subscribe
If you're ready to measure your 60+ biological ages and build a personalized reversal plan, apply for a discovery call here → https://start.gladdenlongevity.com/apply-now
Use code 'Podcast10' to get 10% OFF on any of our supplements at https://gladdenlongevityshop.com/!
Takeaways
· Nikki's journey into the world of Alzheimer's began with her own health struggles.
· Infections can drive autoimmune states and neurodegenerative diseases.
· The medical system often operates in silos, complicating patient care.
· Chronic infections may be overlooked in patients with complex symptoms.
· A systems biology approach is essential for understanding chronic diseases.
· Genetics and the pathobiome are interconnected in disease development.
· Certain infections are linked to both heart disease and Alzheimer's.
· Advocacy and collaboration are crucial for advancing research.
· Lifestyle factors play a significant role in chronic disease prevention.
· Future research should focus on the interplay between infections and chronic diseases. A systems biology approach can optimize health outcomes.
· Collaboration in research is essential for progress.
· AI can provide insights into complex health issues.
· The microbiome plays a crucial role in neurodegenerative diseases.
· Hormonal changes significantly affect aging and health.
· Therapeutic connections between patients and providers are vital.
· Economic incentives often misalign with health outcomes.
· A comprehensive approach to chronic disease is necessary.
· Existing solutions can be leveraged for better health.
· Innovation in healthcare is accelerating rapidly.
Chapters
00:00 Introduction to Alzheimer's and Pathobiome
04:59 Personal Journey: From Illness to Advocacy
10:04 The Role of Infections in Chronic Diseases
15:00 Exploring the Connection Between Heart Disease and Alzheimer's
20:03 Genetics and the Pathobiome: A Complex Relationship
25:03 The Importance of a Systems Biology Approach
30:08 Future Directions in Research and Treatment
30:38 Integrating Systems Biology in Health Optimization
32:25 Collaborative Research and Team Science
34:34 Leveraging AI for Health Insights
36:20 The Role of the Microbiome in Neurodegenerative Diseases
38:21 Hormonal Influences on Aging and Neurodegeneration
40:44 The Therapeutic Connection in Patient Care
42:49 Economic Incentives in Healthcare and Innovation
55:52 A Call for a Manhattan Project in Chronic Disease Research
To learn more about Nikki Schultek:
Website: https://www.alzpi.org/ and https://www.intracellresearchgroup.com/
Instagram: https://www.instagram.com/nikki_schultek/
LinkedIn: https://www.linkedin.com/in/nikki-schultek-03634887/
Reach out to us at:
Website: https://gladdenlongevity.com/
Facebook: https://www.facebook.com/Gladdenlongevity/
Instagram: https://www.instagram.com/gladdenlongevity/?hl=en
LinkedIn: https://www.linkedin.com/company/gladdenlongevity
YouTube: https://www.youtube.com/channel/UC5_q8nexY4K5ilgFnKm7naw
Gladden Longevity Podcast Disclosures
Production & Independence The Gladden Longevity Podcast and Age Hackers are produced by Gladden Longevity Podcast, which operates independently from Dr. Jeffrey Gladden's clinical practice and research at Gladden Longevity in Irving, Texas.
Dr. Gladden may serve as a founder, advisor, or investor in select health, wellness, or longevity-related ventures. These may occasionally be referenced in podcast discussions when relevant to educational topics. Any such mentions are for informational purposes only and do not constitute endorsements.
Medical Disclaimer The Gladden Longevity Podcast is intended for educational and informational purposes only. It does not constitute the practice of medicine, nursing, or other professional healthcare services — including the giving of medical advice — and no doctor–patient relationship is formed through this podcast or its associated content.
The information shared on this podcast, including opinions, research discussions, and referenced materials, is not intended to replace or serve as a substitute for professional medical advice, diagnosis, or treatment. Listeners should not disregard or delay seeking medical advice for any condition they may have. Always seek the guidance of a qualified healthcare professional regarding any questions or concerns about your health, medical conditions, or treatment options.
Use of information from this podcast and any linked materials is at the listener's own risk.
Podcast Guest Disclosures Guests on the Gladden Longevity Podcast may hold financial interests, advisory roles, or ownership stakes in companies, products, or services discussed during their appearance. The views expressed by guests are their own and do not necessarily reflect the opinions or positions of Gladden Longevity, Dr. Jeffrey Gladden, or the production team.
Sponsorships & Affiliate Disclosures To support the creation of high-quality educational content, the Gladden Longevity Podcast may include paid sponsorships or affiliate partnerships. Any such partnerships will be clearly identified during episodes or noted in the accompanying show notes.
We may receive compensation through affiliate links or sponsorship agreements when products or services are mentioned on the show. However, these partnerships do not influence the opinions, recommendations, or clinical integrity of the information presented.
Additional Note on Content Integrity All content is carefully curated to align with our mission of promoting science-based, ethical, and responsible approaches to health, wellness, and longevity. We strive to maintain the highest standards of transparency and educational value in all our communications.
From Reactive Care to Preventive Longevity - Episode 352
2026/08/13
In this episode, Dr. Gladden speaks with Dr. Hany Demian about the shift from reactive medicine to prevention, personalization, and longevity-focused care. Dr. Hany shares how his journey through breast surgery, emergency medicine, and chronic pain management led him to a more systems-based approach to health, aging, and healing. They discuss why aging may be better understood as a condition, how patient empowerment changes outcomes, and why nervous system regulation, stress reduction, and individualized care matter as much as diagnostics and therapies.
For Audience
Join the other 20,000+ high-performers getting weekly insights on biological reversal, exponential strategies, and Life Energy optimization→ https://start.gladdenlongevity.com/subscribe
If you're ready to measure your 60+ biological ages and build a personalized reversal plan, apply for a discovery call here → https://start.gladdenlongevity.com/apply-now
Use code 'Podcast10' to get 10% OFF on any of our supplements at https://gladdenlongevityshop.com/!
Takeaways
· Dr. Hany says many chronic conditions are the result of biology drifting over time, not just isolated bad luck
· He emphasizes that healthy patients are rarely rewarded in the current billing system
· His approach is to assess where a patient's biology is now and how far it has diverged from a healthier baseline
· Lifestyle foundations like sleep, nutrition, exercise, and supplements are treated as the first levers
· Dr. Hany believes aging should be classified as a diagnosable, measurable condition
· He points to hallmarks of aging, mitochondrial dysfunction, and epigenetic disruption as actionable signals
· The conversation frames aging as something that can potentially be slowed, prevented, or reversed
· Dr. Gladden discusses the limits of siloed, specialty-based care and linear thinking in medicine
· Both speakers favor a systems biology model that looks at the whole person
· The idea is to find not just the root cause, but the root cause of the root cause
· Dr. Hany says the longevity field can become overly commercialized and supplement-heavy
· He prefers a science-based, selective approach rather than flooding patients with interventions
· The goal is to help the body restore itself with the right support
· He describes building AI tools that track patients through wearables 24/7
· His team combines genetic testing, ongoing data collection, and clinical interpretation
· The aim is to predict future health trajectories and intervene earlier
· Dr. Hany explains that not everyone is a fit for a longevity program
· Patients must qualify, understand the plan, and commit to the process
· He sees the best outcomes when patients become active partners in their care
· Dr. Gladden emphasizes that the nervous system shapes aging, inflammation, cognition, and resilience
· The episode explores parasympathetic versus sympathetic states and the value of flow over chronic stress
· Both speakers agree that unresolved trauma and emotional strain affect physical health
· Dr. Gladden shares how forgiveness can reduce psychic strain and support healing
· Dr. Hany reflects on the difference between being successful and feeling fulfilled
· They both highlight service, courage, and purpose as central to a meaningful life
Chapters
00:00 - Welcome and the shift from reactive to preventive medicine
01:11 - Breast cancer, family motivation, and the limits of surgery
03:56 - Why personalized medicine starts with biology, not billing
05:24 - Sleep, nutrition, exercise, and supplements as prevention tools
06:33 - Aging hallmarks and why aging may be a condition
08:40 - Reductionist medicine versus systems biology
11:23 - Why the longevity field needs standards and science
14:56 - Patient selection, trust, and individualized care plans
16:25 - Patients as partners, not passive recipients
19:54 - Longevity as adding life to years, not just years to life
20:22 - Stem cells, MSCs, peptides, exosomes, and plasma exchange
21:50 - Brain health, heart health, and musculoskeletal care
22:48 - AI, wearables, and real-time patient monitoring
25:20 - Predicting health five, ten, and fifteen years ahead
26:53 - The nervous system, stress, and psycho-spiritual health
30:25 - Teaching people to live from parasympathetic flow
33:24 - Forgiveness, psychic barriers, and emotional healing
35:42 - Why psychological health improves regenerative outcomes
36:22 - Finding purpose after success
39:15 - Success versus fulfillment
41:17 - Small daily acts of generosity as a path to joy
To learn more about Dr. Hany Demian:
Website: https://drdemian.com/
Instagram: https://www.instagram.com/drhanydemian/
LinkedIn: https://www.linkedin.com/in/hany-demian-md-5b79b659/
YouTube: https://www.youtube.com/@drhanydemain
TikTok: https://www.tiktok.com/@dochanydemian
Reach out to us at:
Website: https://gladdenlongevity.com/
Facebook: https://www.facebook.com/Gladdenlongevity/
Instagram: https://www.instagram.com/gladdenlongevity/?hl=en
LinkedIn: https://www.linkedin.com/company/gladdenlongevity
YouTube: https://www.youtube.com/channel/UC5_q8nexY4K5ilgFnKm7naw
Gladden Longevity Podcast Disclosures
Production & Independence The Gladden Longevity Podcast and Age Hackers are produced by Gladden Longevity Podcast, which operates independently from Dr. Jeffrey Gladden's clinical practice and research at Gladden Longevity in Irving, Texas.
Dr. Gladden may serve as a founder, advisor, or investor in select health, wellness, or longevity-related ventures. These may occasionally be referenced in podcast discussions when relevant to educational topics. Any such mentions are for informational purposes only and do not constitute endorsements.
Medical Disclaimer The Gladden Longevity Podcast is intended for educational and informational purposes only. It does not constitute the practice of medicine, nursing, or other professional healthcare services — including the giving of medical advice — and no doctor–patient relationship is formed through this podcast or its associated content.
The information shared on this podcast, including opinions, research discussions, and referenced materials, is not intended to replace or serve as a substitute for professional medical advice, diagnosis, or treatment. Listeners should not disregard or delay seeking medical advice for any condition they may have. Always seek the guidance of a qualified healthcare professional regarding any questions or concerns about your health, medical conditions, or treatment options.
Use of information from this podcast and any linked materials is at the listener's own risk.
Podcast Guest Disclosures Guests on the Gladden Longevity Podcast may hold financial interests, advisory roles, or ownership stakes in companies, products, or services discussed during their appearance. The views expressed by guests are their own and do not necessarily reflect the opinions or positions of Gladden Longevity, Dr. Jeffrey Gladden, or the production team.
Sponsorships & Affiliate Disclosures To support the creation of high-quality educational content, the Gladden Longevity Podcast may include paid sponsorships or affiliate partnerships. Any such partnerships will be clearly identified during episodes or noted in the accompanying show notes.
We may receive compensation through affiliate links or sponsorship agreements when products or services are mentioned on the show. However, these partnerships do not influence the opinions, recommendations, or clinical integrity of the information presented.
Additional Note on Content Integrity All content is carefully curated to align with our mission of promoting science-based, ethical, and responsible approaches to health, wellness, and longevity. We strive to maintain the highest standards of transparency and educational value in all our communications.
The Exponential Curve of Aging - Episode 351
2026/08/06
Michael Clinton and Dr. Gladden explore the concept of longevity and the evolving perception of aging. They discuss the importance of viewing the second half of life as an opportunity for growth and adventure rather than a decline. The discussion covers the significance of role models, the idea of life layering to build identities beyond work, the necessity of movement and engagement, and the architectural approach to health through five circles. They also touch on the generational transfer of health and the importance of community and connection in combating loneliness and mental health issues. In this conversation, Michael Clinton and Dr. Gladden explore the interconnected themes of community support, generational trauma, the impact of aging, and the power of creativity. They discuss how understanding one's family history can help in addressing mental health issues and the importance of embracing aging positively. The dialogue emphasizes the significance of co-creation and friendships across generations, highlighting how these relationships can enhance joy and fulfillment in life.
For Audience
Join the other 20,000+ high-performers getting weekly insights on biological reversal, exponential strategies, and Life Energy optimization→ https://start.gladdenlongevity.com/subscribe
If you're ready to measure your 60+ biological ages and build a personalized reversal plan, apply for a discovery call here → https://start.gladdenlongevity.com/apply-now
Use code 'Podcast10' to get 10% OFF on any of our supplements at https://gladdenlongevityshop.com/!
Takeaways
· We're living 21st century lives in 20th century constructs.
· Aging is an exponential decline, not a linear decline.
· If you're 65 and healthy, you're gonna live to 95.
· Life layering is building another identity beyond profession.
· The number one natural medicine is movement.
· You can start life layering at any age.
· Generational transfer of health is crucial for longevity.
· Community ensures that the elderly have daily human contact.
· Loneliness and depression are closely linked.
· Living life in flow can reduce stress and loneliness. We need to look out for each other regarding mental health.
· Understanding genetics can help us support individuals better.
· Generational trauma can affect our mental health and well-being.
· Knowing your family history is crucial for personal growth.
· Trauma can imprint on our nervous systems and affect our lives.
· Aging should be embraced, not feared or stigmatized.
· Creativity can enhance longevity and well-being.
· Co-creation with others brings joy and satisfaction.
· Friendships across generations enrich our lives.
· The narrative around aging is changing, and we must adapt.
Chapters
00:00 Roaring into the Second Half of Life
02:50 The Exponential Curve of Aging and Opportunities
05:48 Role Models for Future Generations
09:01 Life Layering: Building Identities Beyond Work
12:06 The Importance of Movement and Engagement
15:09 Architecting Longevity: Five Circles of Health
18:05 Generational Health Transfer and Future Longevity
21:14 Community, Connection, and Loneliness
24:01 The Intersection of Loneliness and Mental Health
25:08 Understanding Generational Trauma
26:27 The Impact of Trauma on Health
28:40 Embracing Aging and Wisdom
30:34 Redefining Aging in Society
32:02 The Power of Creativity for Longevity
36:41 The Joy of Co-Creation and Friendship
To learn more about Michael Clinton:
Email: [email protected]
Reach out to us at:
Website: https://gladdenlongevity.com/
Facebook: https://www.facebook.com/Gladdenlongevity/
Instagram: https://www.instagram.com/gladdenlongevity/?hl=en
LinkedIn: https://www.linkedin.com/company/gladdenlongevity
YouTube: https://www.youtube.com/channel/UC5_q8nexY4K5ilgFnKm7naw
Gladden Longevity Podcast Disclosures
Production & Independence The Gladden Longevity Podcast and Age Hackers are produced by Gladden Longevity Podcast, which operates independently from Dr. Jeffrey Gladden's clinical practice and research at Gladden Longevity in Irving, Texas.
Dr. Gladden may serve as a founder, advisor, or investor in select health, wellness, or longevity-related ventures. These may occasionally be referenced in podcast discussions when relevant to educational topics. Any such mentions are for informational purposes only and do not constitute endorsements.
Medical Disclaimer The Gladden Longevity Podcast is intended for educational and informational purposes only. It does not constitute the practice of medicine, nursing, or other professional healthcare services — including the giving of medical advice — and no doctor–patient relationship is formed through this podcast or its associated content.
The information shared on this podcast, including opinions, research discussions, and referenced materials, is not intended to replace or serve as a substitute for professional medical advice, diagnosis, or treatment. Listeners should not disregard or delay seeking medical advice for any condition they may have. Always seek the guidance of a qualified healthcare professional regarding any questions or concerns about your health, medical conditions, or treatment options.
Use of information from this podcast and any linked materials is at the listener's own risk.
Podcast Guest Disclosures Guests on the Gladden Longevity Podcast may hold financial interests, advisory roles, or ownership stakes in companies, products, or services discussed during their appearance. The views expressed by guests are their own and do not necessarily reflect the opinions or positions of Gladden Longevity, Dr. Jeffrey Gladden, or the production team.
Sponsorships & Affiliate Disclosures To support the creation of high-quality educational content, the Gladden Longevity Podcast may include paid sponsorships or affiliate partnerships. Any such partnerships will be clearly identified during episodes or noted in the accompanying show notes.
We may receive compensation through affiliate links or sponsorship agreements when products or services are mentioned on the show. However, these partnerships do not influence the opinions, recommendations, or clinical integrity of the information presented.
Additional Note on Content Integrity All content is carefully curated to align with our mission of promoting science-based, ethical, and responsible approaches to health, wellness, and longevity. We strive to maintain the highest standards of transparency and educational value in all our communications.
Unlocking the Secrets of Nutrigenomics - Episode 350
2026/07/30
In this conversation, Dr. Gladden and Annelie Smith explore the intersection of genetics and nutrition, emphasizing the importance of personalized approaches to health. They discuss the evolution of nutrigenomics, the role of AI in developing tailored health plans, and the complexities of hormonal balance as influenced by genetics. Annelie shares insights from her clinical experience, highlighting the need for a systems biology approach to understand the intricate relationships between genes, hormones, and overall health. The discussion also touches on future directions in genetic testing and the potential for more accessible and actionable insights for individuals. In this conversation, Dr. Gladden and Annelie Smith delve into the complexities of hormone replacement therapy, emphasizing the importance of understanding hormonal pathways and the role of genetics. They discuss how stress impacts hormonal balance and the significance of reprogramming the nervous system for better health outcomes. The conversation also highlights the relevance of nutrigenomics in personalized nutrition and the powerful benefits of sulforaphane. Finally, they explore the value of genetic testing for optimizing health and wellness.
For Audience
Join the other 20,000+ high-performers getting weekly insights on biological reversal, exponential strategies, and Life Energy optimization→ https://start.gladdenlongevity.com/subscribe
If you're ready to measure your 60+ biological ages and build a personalized reversal plan, apply for a discovery call here → https://start.gladdenlongevity.com/apply-now
Use code 'Podcast10' to get 10% OFF on any of our supplements at https://gladdenlongevityshop.com/!
Use the code GLADDEN20 for $20 off at https://3x4genetics.com/pages/gladden !
Takeaways
· Nutrigenomics provides insights into personalized nutrition.
· Understanding genetics can enhance dietary recommendations.
· AI is transforming the landscape of personalized medicine.
· Systems biology offers a holistic view of health.
· Patient engagement is key to successful health interventions.
· Genetic testing can reveal vulnerabilities in health.
· Hormonal balance is influenced by genetic factors.
· Personalized health plans can improve patient outcomes.
· The future of genetics holds promise for broader applications.
· Access to genetic information can empower individuals. Hormone replacement therapy is complex and requires a systems approach.
· Understanding genetic pathways is crucial for effective hormone management.
· Stress significantly impacts hormonal balance and overall health.
· Reprogramming the nervous system can alleviate stress and improve health.
· Nutrigenomics plays a vital role in personalized nutrition.
· Sulforaphane is a powerful compound with numerous health benefits.
· Diet should be tailored to the individual, not a one-size-fits-all approach.
· Genetic testing provides valuable insights for health optimization.
· Managing stress involves rebuilding mental constructs that generate it.
· Investing in genetic testing is a one-time opportunity with lasting benefits.
Chapters
00:00 Introduction to Nutrigenomics and Personalization
02:49 The Role of Genetics in Nutrition
06:01 Systems Biology Approach to Health
08:55 AI in Nutrigenomics and Personalized Medicine
11:51 Case Study: Hormonal Balance and Genetics
14:59 Future Directions in Genetics and Health
23:35 Understanding Hormone Replacement Therapy
26:16 The Complexity of Hormonal Pathways
28:26 The Role of Stress in Hormonal Balance
30:22 Reprogramming the Nervous System
32:37 Nutrigenomics and Personalized Nutrition
36:27 The Power of Sulforaphane
39:04 Exploring Genetic Testing for Health Optimization
To learn more about Annelie Smith:
Email: [email protected]
Website: www.3X4Genetics.com
Reach out to us at:
Website: https://gladdenlongevity.com/
Facebook: https://www.facebook.com/Gladdenlongevity/
Instagram: https://www.instagram.com/gladdenlongevity/?hl=en
LinkedIn: https://www.linkedin.com/company/gladdenlongevity
YouTube: https://www.youtube.com/channel/UC5_q8nexY4K5ilgFnKm7naw
Gladden Longevity Podcast Disclosures
Production & Independence The Gladden Longevity Podcast and Age Hackers are produced by Gladden Longevity Podcast, which operates independently from Dr. Jeffrey Gladden's clinical practice and research at Gladden Longevity in Irving, Texas.
Dr. Gladden may serve as a founder, advisor, or investor in select health, wellness, or longevity-related ventures. These may occasionally be referenced in podcast discussions when relevant to educational topics. Any such mentions are for informational purposes only and do not constitute endorsements.
Medical Disclaimer The Gladden Longevity Podcast is intended for educational and informational purposes only. It does not constitute the practice of medicine, nursing, or other professional healthcare services — including the giving of medical advice — and no doctor–patient relationship is formed through this podcast or its associated content.
The information shared on this podcast, including opinions, research discussions, and referenced materials, is not intended to replace or serve as a substitute for professional medical advice, diagnosis, or treatment. Listeners should not disregard or delay seeking medical advice for any condition they may have. Always seek the guidance of a qualified healthcare professional regarding any questions or concerns about your health, medical conditions, or treatment options.
Use of information from this podcast and any linked materials is at the listener's own risk.
Podcast Guest Disclosures Guests on the Gladden Longevity Podcast may hold financial interests, advisory roles, or ownership stakes in companies, products, or services discussed during their appearance. The views expressed by guests are their own and do not necessarily reflect the opinions or positions of Gladden Longevity, Dr. Jeffrey Gladden, or the production team.
Sponsorships & Affiliate Disclosures To support the creation of high-quality educational content, the Gladden Longevity Podcast may include paid sponsorships or affiliate partnerships. Any such partnerships will be clearly identified during episodes or noted in the accompanying show notes.
We may receive compensation through affiliate links or sponsorship agreements when products or services are mentioned on the show. However, these partnerships do not influence the opinions, recommendations, or clinical integrity of the information presented.
Additional Note on Content Integrity All content is carefully curated to align with our mission of promoting science-based, ethical, and responsible approaches to health, wellness, and longevity. We strive to maintain the highest standards of transparency and educational value in all our communications.
The Microbial Connection to Autoimmunity - Episode 349
2026/07/23
In this episode of the Gladden Longevity Podcast, Dr. Gladden interviews Dr. Bill Rawls, who shares his transformative journey from conventional medicine to holistic healing. Bill discusses his struggles with chronic illness, particularly Lyme disease, and how he discovered the importance of cellular health and autophagy in recovery. He emphasizes the role of herbal therapies and adaptogens in promoting wellness and protecting cellular function, ultimately leading to a deeper understanding of chronic illness and aging. In this conversation, they explore the intricate connections between autoimmunity, chronic illness, and the role of microbial influences. They discuss the implications of long COVID, the benefits of adaptogenic herbs, and the importance of nervous system regulation in healing. The conversation emphasizes the need for a holistic approach to health, focusing on creating a supportive environment for healing and the potential of herbal medicine in managing chronic conditions.
For Audience
Join the other 20,000+ high-performers getting weekly insights on biological reversal, exponential strategies, and Life Energy optimization→ https://start.gladdenlongevity.com/subscribe
If you're ready to measure your 60+ biological ages and build a personalized reversal plan, apply for a discovery call here → https://start.gladdenlongevity.com/apply-now
Use code 'Podcast10' to get 10% OFF on any of our supplements at https://gladdenlongevityshop.com/!
Takeaways
· Dr. Bill Rawls transitioned from conventional medicine to holistic healing due to personal health struggles.
· Chronic Lyme disease was a pivotal point in Dr. Bill's journey, leading him to explore alternative therapies.
· Understanding cellular health is crucial for addressing chronic illnesses.
· Autophagy is a key process for cellular rejuvenation and health.
· Herbal therapies can effectively support the body's healing processes.
· Adaptogens help the body adapt to stress and promote resilience.
· Impaired autophagy is linked to many chronic illnesses.
· Dr. Bill emphasizes the importance of diet, sleep, and lifestyle in maintaining health.
· Herbs can protect cells from stress and inflammation.
· The journey of healing is often non-linear and requires exploration of various therapies. Autoimmunity may be driven by microbial invasion and immune response.
· Long COVID symptoms could be linked to reactivation of dormant pathogens.
· Adaptogenic herbs can support cellular health and stress management.
· Nervous system regulation is crucial for effective healing.
· Herbal preparations can be more effective than traditional medications.
· Creating a healthy environment is essential for chronic illness management.
· The body's stress response can exacerbate chronic health issues.
· Herbs can provide a broad spectrum of benefits beyond just antimicrobial effects.
· Education and environment play key roles in health improvement.
· Chronic illness management requires a shift in healthcare focus.
Chapters
00:00 Dr. Bill Rawls' Journey from Conventional Medicine to Holistic Healing
05:12 Understanding Lyme Disease and Chronic Illness
10:46 The Role of Autophagy in Health and Disease
16:36 Herbal Therapies and Adaptogens in Healing
25:20 Protecting Cellular Health and Mitochondrial Function
26:20 Understanding Autoimmunity and Microbial Influence
28:02 Long COVID and Chronic Illness Connections
30:14 The Role of Adaptogenic Herbs in Healing
32:07 Nervous System Regulation and Healing
33:55 Herbal Preparations and Their Efficacy
37:54 The Broad Spectrum of Herbal Medicine
40:59 Creating a Healthy Environment for Healing
49:03 The Future of Health and Chronic Illness Management
To learn more about Dr. Bill Rawls:
Facebook: https://www.facebook.com/rawlsmd/
Website: rawlsmd.com
Instagram: https://www.instagram.com/rawlsmd/
Reach out to us at:
Website: https://gladdenlongevity.com/
Facebook: https://www.facebook.com/Gladdenlongevity/
Instagram: https://www.instagram.com/gladdenlongevity/?hl=en
LinkedIn: https://www.linkedin.com/company/gladdenlongevity
YouTube: https://www.youtube.com/channel/UC5_q8nexY4K5ilgFnKm7naw
Gladden Longevity Podcast Disclosures
Production & Independence The Gladden Longevity Podcast and Age Hackers are produced by Gladden Longevity Podcast, which operates independently from Dr. Jeffrey Gladden's clinical practice and research at Gladden Longevity in Irving, Texas.
Dr. Gladden may serve as a founder, advisor, or investor in select health, wellness, or longevity-related ventures. These may occasionally be referenced in podcast discussions when relevant to educational topics. Any such mentions are for informational purposes only and do not constitute endorsements.
Medical Disclaimer The Gladden Longevity Podcast is intended for educational and informational purposes only. It does not constitute the practice of medicine, nursing, or other professional healthcare services — including the giving of medical advice — and no doctor–patient relationship is formed through this podcast or its associated content.
The information shared on this podcast, including opinions, research discussions, and referenced materials, is not intended to replace or serve as a substitute for professional medical advice, diagnosis, or treatment. Listeners should not disregard or delay seeking medical advice for any condition they may have. Always seek the guidance of a qualified healthcare professional regarding any questions or concerns about your health, medical conditions, or treatment options.
Use of information from this podcast and any linked materials is at the listener's own risk.
Podcast Guest Disclosures Guests on the Gladden Longevity Podcast may hold financial interests, advisory roles, or ownership stakes in companies, products, or services discussed during their appearance. The views expressed by guests are their own and do not necessarily reflect the opinions or positions of Gladden Longevity, Dr. Jeffrey Gladden, or the production team.
Sponsorships & Affiliate Disclosures To support the creation of high-quality educational content, the Gladden Longevity Podcast may include paid sponsorships or affiliate partnerships. Any such partnerships will be clearly identified during episodes or noted in the accompanying show notes.
We may receive compensation through affiliate links or sponsorship agreements when products or services are mentioned on the show. However, these partnerships do not influence the opinions, recommendations, or clinical integrity of the information presented.
Additional Note on Content Integrity All content is carefully curated to align with our mission of promoting science-based, ethical, and responsible approaches to health, wellness, and longevity. We strive to maintain the highest standards of transparency and educational value in all our communications.
The Cost-Effectiveness of Compounding Pharmacies - Episode 348
2026/07/16
In this episode of the Gladden Longevity podcast, Dr. Gladden interviews Shaun Noorian from Empower Pharmacy, discussing the growth and mission of the pharmacy, the cost-effectiveness of compounding medications, quality standards in compounding, regulatory oversight, and the ongoing controversy surrounding peptides and FDA decisions. The conversation highlights the importance of personalized medicine and the challenges faced by compounding pharmacies in providing affordable and effective treatments for patients. In this conversation, Dr. Gladden and Shaun Noorian discuss the evolving landscape of compounding pharmacies and personalized medicine. They explore the regulatory challenges faced by compounding pharmacies, the promise of new medications like retatrutide, and the role of GLP-1s in health management. The discussion highlights the importance of muscle preservation in weight loss therapies and the advocacy needed to ensure patient access to compounded medications. They emphasize the renaissance of compounding in healthcare, which is making treatments more accessible and affordable for patients.
For Audience
Join the other 20,000+ high-performers getting weekly insights on biological reversal, exponential strategies, and Life Energy optimization→ https://start.gladdenlongevity.com/subscribe
If you're ready to measure your 60+ biological ages and build a personalized reversal plan, apply for a discovery call here → https://start.gladdenlongevity.com/apply-now
Use code 'Podcast10' to get 10% OFF on any of our supplements at https://gladdenlongevityshop.com/!
Takeaways
· Empower Pharmacy has been operational for 17 years and focuses on personalized medicine.
· Compounding pharmacies are becoming more popular due to their cost-effectiveness compared to commercial options.
· Quality standards in compounding are well-established and continuously updated.
· Compounding pharmacies are subject to rigorous regulatory oversight and inspections.
· The FDA is currently reviewing the status of several peptides for compounding.
· Recent changes in the FDA advisory committee may impact the approval of new compounds.
· The conversation emphasizes the need for evidence-based decisions in healthcare.
· Dr. Gladden highlights the discrepancies in drug approvals and their implications for patient care.
· The black market for peptides poses significant risks to patient safety.
· The discussion underscores the importance of maintaining high-quality standards in compounding pharmacies. The FDA's decisions will significantly impact compounding pharmacies.
· Compounding pharmacies ensure medication integrity and safety.
· Personalized medicine is expanding into various health areas.
· Regulatory challenges hinder the compounding of certain medications.
· Retatrutide is expected to revolutionize weight loss therapies.
· GLP-1s have multiple health benefits beyond weight loss.
· Weight loss therapies can lead to muscle loss, complicating health outcomes.
· Innovative alternatives to GLP-1s are emerging in the market.
· Compounding pharmacies play a crucial role in patient access to medications.
· Advocacy against pharmaceutical monopolies is essential for patient care.
Chapters
00:00 Empower Pharmacy's Growth and Mission
03:01 Cost-Effectiveness of Compounding Pharmacies
06:00 Quality Standards in Compounding
08:54 Regulatory Oversight and Compliance
12:01 The Peptide Controversy
15:03 The Impact of FDA Decisions on Patient Care
18:21 The Future of Compounding Pharmacies
20:09 Expanding Areas of Personalized Medicine
21:11 Regulatory Challenges in Compounding
22:04 The Promise of Retatrutid
23:39 The Role of GLP-1s in Health
25:02 The Impact of Weight Loss Therapies
26:07 Innovative Alternatives to GLP-1s
27:10 The Importance of Muscle Preservation
28:31 The Role of Compounding Pharmacies in Patient Access
30:16 Advocacy Against Pharmaceutical Monopolies
32:20 Navigating Regulatory Landscapes
34:14 The Renaissance of Compounding in Healthcare
To learn more about Shaun Noorian:
Email: [email protected]
Website: https://www.empowerpharmacy.com/
Instagram: https://www.instagram.com/empowerpharmacy
Reach out to us at:
Website: https://gladdenlongevity.com/
Facebook: https://www.facebook.com/Gladdenlongevity/
Instagram: https://www.instagram.com/gladdenlongevity/?hl=en
LinkedIn: https://www.linkedin.com/company/gladdenlongevity
YouTube: https://www.youtube.com/channel/UC5_q8nexY4K5ilgFnKm7naw
Gladden Longevity Podcast Disclosures
Production & Independence The Gladden Longevity Podcast and Age Hackers are produced by Gladden Longevity Podcast, which operates independently from Dr. Jeffrey Gladden's clinical practice and research at Gladden Longevity in Irving, Texas.
Dr. Gladden may serve as a founder, advisor, or investor in select health, wellness, or longevity-related ventures. These may occasionally be referenced in podcast discussions when relevant to educational topics. Any such mentions are for informational purposes only and do not constitute endorsements.
Medical Disclaimer The Gladden Longevity Podcast is intended for educational and informational purposes only. It does not constitute the practice of medicine, nursing, or other professional healthcare services — including the giving of medical advice — and no doctor–patient relationship is formed through this podcast or its associated content.
The information shared on this podcast, including opinions, research discussions, and referenced materials, is not intended to replace or serve as a substitute for professional medical advice, diagnosis, or treatment. Listeners should not disregard or delay seeking medical advice for any condition they may have. Always seek the guidance of a qualified healthcare professional regarding any questions or concerns about your health, medical conditions, or treatment options.
Use of information from this podcast and any linked materials is at the listener's own risk.
Podcast Guest Disclosures Guests on the Gladden Longevity Podcast may hold financial interests, advisory roles, or ownership stakes in companies, products, or services discussed during their appearance. The views expressed by guests are their own and do not necessarily reflect the opinions or positions of Gladden Longevity, Dr. Jeffrey Gladden, or the production team.
Sponsorships & Affiliate Disclosures To support the creation of high-quality educational content, the Gladden Longevity Podcast may include paid sponsorships or affiliate partnerships. Any such partnerships will be clearly identified during episodes or noted in the accompanying show notes.
We may receive compensation through affiliate links or sponsorship agreements when products or services are mentioned on the show. However, these partnerships do not influence the opinions, recommendations, or clinical integrity of the information presented.
Additional Note on Content Integrity All content is carefully curated to align with our mission of promoting science-based, ethical, and responsible approaches to health, wellness, and longevity. We strive to maintain the highest standards of transparency and educational value in all our communications.
The Future of Regenerative Joint Repair - Episode 347
2026/07/09
In this episode, Dr. Marc Pietropaoli discusses his transition from traditional orthopedics to regenerative medicine, emphasizing the importance of repairing rather than replacing damaged joints. He shares insights on the components and sequencing of regenerative treatments, the role of genetic testing in nutrition, and his mission to eliminate the need for knee replacements by 2043. The conversation highlights the significance of prevention and proactive care in joint health. In this conversation, Dr. Marc Pietropaoli discusses various aspects of injury prevention, particularly focusing on ACL injuries and innovative surgical techniques. He emphasizes the importance of proper landing techniques, dynamic warm-ups, and the role of proprioception in preventing injuries. The discussion also covers the advancements in ACL repair, including the bear procedure, which utilizes a collagen implant to enhance healing and reduce the risk of arthritis. The conversation concludes with resources for further learning and insights into the future of sports medicine.
For Audience
Join the other 20,000+ high-performers getting weekly insights on biological reversal, exponential strategies, and Life Energy optimization→ https://start.gladdenlongevity.com/subscribe
If you're ready to measure your 60+ biological ages and build a personalized reversal plan, apply for a discovery call here → https://start.gladdenlongevity.com/apply-now
Use code 'Podcast10' to get 10% OFF on any of our supplements at https://gladdenlongevityshop.com/!
Takeaways
Dr. Pietropaoli transitioned from traditional orthopedics to regenerative medicine. He emphasizes the body's ability to heal itself through regenerative techniques. The importance of asking questions in medical training is highlighted. Dr. Pietropaoli's personal experiences influenced his career path. He advocates for a team approach in patient care, involving various specialists. Inflammation is a key factor in joint health and must be addressed. Genetic testing can guide nutritional choices for better health outcomes. Preventive measures can significantly reduce the risk of joint injuries. Dr. Pietropaoli aims to end the need for knee replacements by 2043. The conversation underscores the importance of patient education in exploring treatment options. Bending knees during landing reduces injury risk. Proper proprioception is crucial for athletes. Dynamic warm-ups are more effective than static stretching. Mastering two-legged exercises is essential before progressing to one-legged ones. Plyometrics enhance fast twitch muscle fiber development. Agility is linked to balance and quickness. Bear surgery offers a promising alternative to traditional ACL repair. Collagen implants can significantly aid in ACL healing. Using blood flow restriction can enhance recovery post-surgery. Education and awareness are key in sports injury prevention.
Chapters
00:00 Introduction to Regenerative Orthopedics
04:08 The Journey from Traditional to Regenerative Medicine
13:46 Components and Sequencing in Regenerative Treatments
20:04 Genetic Testing and Nutrition for Optimal Health
22:52 Future Aspirations in Joint Health and Prevention
27:09 Injury Prevention Techniques
34:06 Understanding ACL Injuries and Repair
42:35 Innovations in ACL Surgery
45:34 Resources and Final Thoughts
To learn more about Dr. Marc:
Website: www.victoryinmotion.com
TikTok: https://www.tiktok.com/@drmarcpietropaoli
Instagram: https://www.instagram.com/drmarcpietropaoli
LinkedIn: https://www.linkedin.com/in/drmarcpietropaoli
YouTube: https://www.youtube.com/@victoryinmotion1
Reach out to us at:
Website: https://gladdenlongevity.com/
Facebook: https://www.facebook.com/Gladdenlongevity/
Instagram: https://www.instagram.com/gladdenlongevity/?hl=en
LinkedIn: https://www.linkedin.com/company/gladdenlongevity
YouTube: https://www.youtube.com/channel/UC5_q8nexY4K5ilgFnKm7naw
Gladden Longevity Podcast Disclosures
Production & Independence The Gladden Longevity Podcast and Age Hackers are produced by Gladden Longevity Podcast, which operates independently from Dr. Jeffrey Gladden's clinical practice and research at Gladden Longevity in Irving, Texas.
Dr. Gladden may serve as a founder, advisor, or investor in select health, wellness, or longevity-related ventures. These may occasionally be referenced in podcast discussions when relevant to educational topics. Any such mentions are for informational purposes only and do not constitute endorsements.
Medical Disclaimer The Gladden Longevity Podcast is intended for educational and informational purposes only. It does not constitute the practice of medicine, nursing, or other professional healthcare services — including the giving of medical advice — and no doctor–patient relationship is formed through this podcast or its associated content.
The information shared on this podcast, including opinions, research discussions, and referenced materials, is not intended to replace or serve as a substitute for professional medical advice, diagnosis, or treatment. Listeners should not disregard or delay seeking medical advice for any condition they may have. Always seek the guidance of a qualified healthcare professional regarding any questions or concerns about your health, medical conditions, or treatment options.
Use of information from this podcast and any linked materials is at the listener's own risk.
Podcast Guest Disclosures Guests on the Gladden Longevity Podcast may hold financial interests, advisory roles, or ownership stakes in companies, products, or services discussed during their appearance. The views expressed by guests are their own and do not necessarily reflect the opinions or positions of Gladden Longevity, Dr. Jeffrey Gladden, or the production team.
Sponsorships & Affiliate Disclosures To support the creation of high-quality educational content, the Gladden Longevity Podcast may include paid sponsorships or affiliate partnerships. Any such partnerships will be clearly identified during episodes or noted in the accompanying show notes.
We may receive compensation through affiliate links or sponsorship agreements when products or services are mentioned on the show. However, these partnerships do not influence the opinions, recommendations, or clinical integrity of the information presented.
Additional Note on Content Integrity All content is carefully curated to align with our mission of promoting science-based, ethical, and responsible approaches to health, wellness, and longevity. We strive to maintain the highest standards of transparency and educational value in all our communications.
Podcast reviews
Read Gladden Longevity Podcast podcast reviews
elizabeth ballet 2025/05/01
Life changing podcast
I have been listening to this podcast for almost a year now and also studying Dr Gladden’s book. I have been methodically applying things I learn and ...
PS425DC 2022/06/10
Informative
At one time, this was a great podcast. Since the departure of Mark Young, it is not worth the time.
Not Tarts 2022/04/06
Great Information
I started with episode 91 because I take Spermadine and wanted more information from another source on dosing, etc. Amazing, very straightforward info...
Ara747 2021/11/02
I love your podcast.
Please continue to train the audience about alternative medicine. These podcast give me hope. I don’t allow my physician to dictate my health, but it ...
taor20 2021/10/24
Research
After listening I research the different cures out for the diagnosis you’re treating. And like the path you’re on. Thanks
Merlz621 2021/10/20
Amazing and very helpful!
I love everything about this podcast.
It’s the best podcast out there for those of us who want longevity and to live our “best healthy life”. These e...
jfieanv;lkfsang 2021/10/07
Focused and informative
Very knowledgeable Doctors who are focused on longevity. They are more focused than other podcast speakers who seem to be scattershot around many thi...
ratrph 2021/09/04
Dr. Gladden good; Mark Young annoying
Dr. Gladden provides some very interesting information. It appears that Mark Young’s only role is to dumb down the information. I don’t want or need d...
twolf20c 2020/07/29
Just Great
The two episodes on the WuHuFlu are just flat out wonderful, keep up the good work!!
hattonda 2020/07/29
Bias vs Good Science
I think Trump got his latest bad Coronavirus advice here. The latest episode has a snarky guest who mocks mask wearing and even promotes a low dosag...
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