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National Center for Complementary and Integrative Health (NCCIH) Director Wendy Weber and NIH Collaboratory co-PI Adrian Hernandez discuss fit-for-purpose trials and what researchers need to consider during the design phase. This discussion sets the stage for the NIH Collaboratory's 4-part educational podcast series, "Laying the Foundation for Successful Pragmatic Trials." Access resources related to this episode: https://dcricollab.dcri.duke.edu/sites/NIHKR/KR/Podcast%20Episode%201%20Resources.pdf

Alison Huang and Derek Angus of JAMA+ Trials expand on key takeaways from their recent Grand Rounds presentation, “Bringing Context and Clarity to Clinical Trial Research for Clinician and Public Health Audiences.”

Drs. Steven George and Christine Goertz discuss slow recruitment mitigation strategies, one of the small group discussion topics at the NIH Pragmatic Trial Collaboratory's Steering Committee meeting in April 2026. Review the Steering Committee Meeting materials: https://rethinkingclinicaltrials.org/news/april-2026-annual-steering-committee-meeting/

Drs. Brad Hammill and Keith Marsolo discuss the use of death as an endpoint, a section in the Living Textbook chapter on Choosing and Specifying Endpoints and Outcomes. Read the chapter: https://rethinkingclinicaltrials.org/chapters/design/choosing-specifying-end-points-outcomes/choosing-and-specifying-endpoints-and-outcomes-introduction/

Roy Perlis of Harvard Medical School and JAMA+ AI expands on key takeaways from his recent Grand Rounds presentation, “Keeping a Human in the Loop: Scientific Publishing and AI.”

Majid Afshar and Mary Ryan Baumann discuss the conduct and results of their pragmatic trial.

Drs. Jonathan Moyer and David Murray discuss their recent publication, “Evaluating Analytic Models for Individually Randomized Group Treatment Trials With Complex Clustering in Nested and Crossed Designs.”

Drs. Adrian Hernandez and Christopher Lindsell discuss their recent publication, “Ensuring Virtual Vigilance in Decentralized Clinical Trials," as well as the new Living Textbook Chapter on Decentralized Pragmatic Clinical Trials.

Dr. David Zaas discusses key takeaways from his recent keynote presentation: “Landscape of Healthcare in America: Gaps and Opportunities (That Researchers Need to Hear)."

Drs. Shruti Gohil and Jeffrey Guy discuss key takeaways from "INtelligent Stewardship Prompts to Improve Real-time Empiric Antibiotic Selection for Patients," also known as the INSPIRE trial.

Drs. Sebastian Tong and Julie Fritz expand on key takeaways from their recent Grand Rounds presentation.

Dr. Emily O'Brien shares key takeaways from her recent Grand Rounds presentation, "Avoiding the Fumble: Building on a Decade of Lessons from Pragmatic Clinical Trials."

Drs. Greg Simon and Lorella Palazzo discuss their recent Living Textbook Chapter, "End-of-Trial Decision-Making." Read the chapter: https://rethinkingclinicaltrials.org/chapters/dissemination/end-of-trial-decision-making/introduction-end-of-trial-decision-making/

Drs. Pearl O'Rourke and David Wendler discuss their recent publication, "Disentangling Informing Participants From Obtaining Their Consent."

Drs. Lesley Curtis and Keith Marsolo discuss the new learning module "Healthcare Data Interoperability and Standardization for Research."