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AbbVie CEO Richard Gonzalez, who grew the company into a pharmaceutical juggernaut, is preparing to retire. Crain's health care reporter Katherine Davis talks with host Amy Guth about the leadership change and the drugmaker's M&A plans. Plus: Allstate looks to unload Wacker Drive office building, Northwestern grad students reach first tentative union contract deal, Mag Mile retail space sold to firms known for amassing distressed malls and Duckworth moves to protect in vitro fertilization after Alabama ruling.

Chicago-area new home sales had their second-best year of the past 15. Crain's residential real estate reporter Dennis Rodkin discusses that and other news from the local housing market with host Amy Guth. Plus: World Business Chicago appoints an interim executive; Gov. Pritzker wants $500 million for quantum technology; cultivated-meat company puts plans for Glenview plant on hold; and after altercation, City Council member calls on colleague to resign leadership posts.

White Sox owner and Chairman Jerry Reinsdorf is confident he can get a state subsidy for new South Loop stadium. Crain's politics reporter Justin Laurence discusses the latest with host Amy Guth. Plus: AbbVie names new CEO; Oreo maker Mondelez is strong as ever in Russia as war drags on; Capital One to buy Discover in deal valued at over $35 billion; and for hospitals, largely exposed to cyberattacks, Lurie demonstrates how bad it can get.

The Sheraton Grand Chicago is changing hands in a $500 million deal. Crain’s commercial real estate reporter Rachel Herzog discusses that and other news from around the market with host Amy Guth. Plus: Penny Pritzker, others subpoenaed in Harvard antisemitism probe; City Council, shunning arbitrator and police union's warnings, rejects discipline ruling again; electronics supplier Newark is closing its Chicago office; and UChicago to fight inequity in cancer care with new center.

Architectural Artifacts is leaving for Texas after nearly four decades in Chicago. Crain's retail reporter Ally Marotti talks with host Amy Guth about the shift. Plus: One of Chicago's largest hotels changing hands in $500 million deal, commercial-property loans coming due in U.S. jump to $929 billion, new Chicago Fed index sees more moderate gain in January retail sales, Chicago Fed chief says inflation can be a bit higher on the path to the 2% target and workers at the Museum of Contemporary Art Chicago announce union campaign.

Crain's labor reporter Brandon Dupré and host Amy Guth discuss what's driving the unionization push at Tempus. Plus: Chicago braces for first post-pandemic property tax assessment, Howard Brown Health CEO to depart, the new Foxtrot and Dom's Kitchen CEO has Whole Foods on his resume and Old Orchard mall owner taps local developer for 400-unit apartment project.

On an evolving Taylor Street, once Chicago's epicenter of Italian cuisine, restaurants are struggling. Crain's reporter Ally Marotti talks about the changing neighborhood with host Amy Guth. Plus: Part of Walgreens HQ poised for residential development, Deerfield reportedly set to ban warehouses and distribution facilities, Rivian cuts prices on base R1T and R1S models, and Lion Electric to get nearly $50 million in EV incentives — much more than expected.

For Gov. J.B. Pritzker, the DNC could be a dress rehearsal for a presidential run. Crain’s politics reporter Leigh Giangreco discusses with host Amy Guth. Plus: Revised Bally's site plan gets green light from City Hall, treasurer's office lowers late fees for property taxes, Lurie confirms network breached by "known criminal threat actor," US Foods wins lawsuit against Boston Market and Northwestern eyes football games at Wrigley, Guaranteed Rate and Soldier Field.

Crain’s residential real estate reporter Dennis Rodkin talks with host Amy Guth about news from the local housing market, including the 50 highest-priced home sales of 2023, Illinois Realtors’ $1 million campaign against a transfer-tax increase, and Cook County’s plan to make homes healthier for owners and renters. Plus: Smaller banks face bigger risks from the depressed commercial real estate market, judge ends Byron Allen's lawsuit over McDonald's ad spending, museum hotel in River North hits the market and Winnetka passes lakefront ordinance despite threat of lawsuits.

The Bears' focus for a new stadium is not on Arlington Heights but Chicago’s lakefront. Crain's political columnist Greg Hinz talks with host Amy Guth about the latest developments in the saga. Plus: DOJ launches probe into ADM over accounting practices, Kroger CFO exits during uncertainty over Albertsons merger, Rush lays off administrative staff, FAA chief vows to hold Boeing accountable for quality lapses as aerospace workers demand pay raises and Rivian teases first look at smaller and less expensive electric SUV.

Some Chicago cannabis companies are collaborating with restaurants and mainstream food brands on new THC-infused products like wing sauce and cake mixes. Crain's reporter Ally Marotti talks with host Amy Guth about how the move indicates Illinois' cannabis industry is maturing. Plus: Trump's Chicago tower loan at issue in delayed New York fraud case, warehouse vacancy inches up, Fed's Goolsbee says he wants to see more inflation progress and Illinois getting share of $500 million opioid settlements.

When Boeing came to Chicago in 2001, it was a win for the city. But was it good for the company? Crain’s Steven Strahler talks with host Amy Guth about the troubled planemaker. Plus: U of I's Discovery Partners Institute chief is stepping down, AbbVie sees signs of post-Humira growth in positive 2024 outlook, 180 laid off from University of Chicago Medical Center, and cannabis rescheduling faces an uphill battle, but DEA decision expected soon.