Advertise on podcast: Discover CircRes

This month on Episode 88 of Discover CircRes, host Cindy St. Hilaire highlights articles featured in the August 28th and September 11th issues of Circulation Research. This Episode also features a discussion with Dr Klaus Ley about his study, "Increased Autoreactive CD8+ T Cells to Apolipoprotein B Epitopes in Patients with Severe Coronary Artery Disease."   Article highlights: Wang, et al. Methylmalonate Drives Diabetic Heart Damage Zheng, et al. TLS and CXCL13 Axis in Intracranial Aneurysms Zhou, et al. A Glyco-Epigenetic Driver of Heart Failure Wang, et al Formononetin as an ERRα Agonist Alleviates AIC

This month on Episode 87 of Discover CircRes, host Cindy St. Hilaire highlights articles featured in the July 31st and August 14th issues of Circulation Research. This Episode also features a discussion with Drs Jonathan Kirk, Laura Sherer, and Abigail Nagle about their study, "Contractility Drives Cardiomyocyte Maturation and the Response to Nanopatterns."   Article highlights: Zhang, et al. Mitochondrial STING Reprograms Glycolysis Daou, et al. TFEB Antagonizes Pathological Cardiac Hypertrophy Crepin, et al. Macrophage Subsets Contribute to Atrial Remodeling Okamura, et al. Stochastic Resonance Prevents Sinus Arrest

This month on Episode 86 of Discover CircRes, host Cindy St. Hilaire highlights articles featured in the July 6 and July 17th issues of Circulation Research. This Episode also features a discussion with BCVS Outstanding Early Career Investigator Award Finalists, Drs Noor Momin, Shibali Das, and Ivan Menendez-Montes.   Article highlights: Kotla, et al. LATS1/2-CD38-SUOX Axis Drives Intraplaque Thrombosis Lin, et al. ATAD3A Gates Mito-Lysosome Contacts in AAD Wang, et al. Monocyte Dll4 Induces Systemic Inflammation Chattopadhyay, et al. S100A8/A9 Aggravate Atherosclerosis

This month on Episode 85 of Discover CircRes, host Cindy St. Hilaire highlights articles featured in the May 22nd, June 5th and June 19th issues of Circulation Research. This Episode also features a discussion with Professor Katrin Schäfer, Dr Rajinikanth Gogiraju, and Dr Beichen Sun, about their study, Chronic Erythrocyte NO Production Accelerates Atherosclerosis by Increasing SMC De Novo Lipogenesis.   Article highlights: Larcher, et al. Cardiac Fibroblast Heterogeneity and Disease Huang, et al. Vascular Endothelial NOX1 Drives Obesity Atici, et al. Role of Sirtuin-1 in Murine Vasculitis Compendium on Lipoproteins and Cardiovascular Disease

This month on Episode 84 of Discover CircRes, host Cindy St. Hilaire highlights articles featured in the April 24th and May 8th issue of Circulation Research. This Episode also features a discussion with Dr Mete Civelek and Dr Noah Perry about their study, Female-Biased Vascular Smooth Muscle Cell Gene Regulatory Networks Predict MYH9 as a Key Regulator of Fibrous Plaque Phenotype.   Article highlights: Westhoff, et al. PTEN and PIP3 in AngII-Induced Cardiac Pathology Witmer, et al. Novel Mode of SCN5A-Mitochondrial Crosstalk Ghiringhelli, et al. Light-Controllable Humanized Bioengineered Atria Wang, et al. Exercise-Induced Cardiomyocyte EVs Deliver EPPIR

This month on Episode 83 of Discover CircRes, host Cindy St. Hilaire highlights articles featured in the March 27th and April 10th issue of Circulation Research. This Episode also features a discussion with Dr Martin Schwartz and Dr Hanqiang Deng about their study, FOXO1 Integrates Endothelial Hemodynamic, Inflammatory, and Metabolic Pathways in Atherosclerosis.   Article highlights: Tadokoro, et al. CRISPR Base Editing of PKCα Rescues Heart Failure Joki, et al. PTH Affects Right Heart Hemodynamics Compendium on Migration of Mitochondria Beyond Cell Boundary

This month on Episode 82 of Discover CircRes, host Cindy St. Hilaire highlights articles featured in the February 27th and March 13th issue of Circulation Research. This Episode also features a discussion with Dr John Hall and Dr Ana Omoto from the University of Mississippi Medical Center about their study, Leptin Activates Brain-BAT-Heart Crosstalk to Promote Cardiac Protection.   Article highlights: Sakkers, et al. Atherosclerotic Fibrous Plaques in Women Ruberto, et al. Mitochondrial Biogenesis and Heart Regeneration Simon-Chica, et al. Non-Myocytes Modulate Atrial Fibrillation Dynamics Zhao, et al. USP10 Inhibits cGAS-STING via MTX2

This month on Episode 81 of Discover CircRes, host Cindy St. Hilaire highlights articles featured in the January 30th and February 13th issue of Circulation Research. This Episode also features a discussion with Dr Claudia Goettsch and Nicolas Hense, about their study, 1-Phosphatidylinositol 3-Phosphate 5-Kinase Inhibition by Apilimod Promotes an Adipocyte-like Vascular Smooth Muscle Cell Phenotype and Prevents Arterial Calcification.   Article highlights: Hu, et al. CircZBTB44 Inhibits Calcific Aortic Valve Disease Schemelei, et al. Olfr2 Aggravates AAA Formation Zhang, et al. Neratinib Protects Against Atherosclerosis Sun, et al. CD34+ Cells in Transplants

This month on Episode 80 of Discover CircRes, host Cindy St. Hilaire highlights articles featured in the January 2nd and January 16th issue of Circulation Research. This Episode also features a discussion with Dr Colin Evans and Dr You-Yang Zhao about their study, The Unexpected Protective Role of Thrombosis in Lung Injury via Endothelial ALOX15.   Article highlights: Viskadourou, et al. Endothelial REST in Atherosclerosis Torre, et al. Silencing the Chronotropic Heart Rate Response Chen, et al. Histone Lactylation and Cardiac Hypertrophy Vázquez-Reyes, et al. Diurnal Neutrophil Function Drives Stroke Outcome

This month on Episode 79 of Discover CircRes, host Cindy St. Hilaire highlights articles featured in the December 5th issue of Circulation Research. This Episode also features a discussion with Dr Nobuaki Fukuma and Dr Emily Tsai from Columbia University Vagelos College of Physicians and Surgeons about their study, Cardiomyocyte GC1 Mediates Estrogenic Angiogenesis in Right Heart Remodeling.   Article highlights: Hamilton, et al. RyR2 Hyperactivity Remodels Mitochondria Singhal, et al. TRIB3 Activation Impairs Efferocytosis Tsai, et al. YAP Induces Glycolysis to Drive Fibroinflammation

This month on Episode 78 of Discover CircRes, host Cindy St. Hilaire highlights articles featured in the October 24th and November 7th issues of Circulation Research. This Episode also features a discussion with Thomas Hund and  Drew Nassal from the Ohio State University about their study, The βIV-Spectrin/STAT3 Complex Regulates the Orientation of Cardiac Hypertrophic Growth.   Article highlights: Dhawan, et al. Macrophage DNases Clear Tissue NETs Pakkiriswami, et al. LV and RV Responses to Elevated Mitochondrial Ca2+ Liu, et al. CCL21 Enhances Platelet Activation Morales, et al. Vascular Niches and Cardiac Aging

This month on Episode 76 of Discover CircRes, host Cindy St. Hilaire highlights articles featured in the August 29th and September 12th issues of Circulation Research. This Episode also features a discussion with Drs Swapnil Sonkusare and Mani Kuppusamy about their manuscript, Paracrine Smooth Muscle-to-Endothelial Signaling via TNF Elevates Blood Pressure in Obesity.   Article highlights: Tombor, et al. Immunomodulatory Endothelial Cells After Heart Attack Du, et al. CAR-Ms Engineered In Vivo for Attenuating MIRI Pauza, et al. MC4R Activates Carotid Body in Hypertension Cai, et al. Lkb1 KO in PVAT Drives Aortic Aneurysm Formation

This month on Episode 75 of Discover CircRes, host Cindy St. Hilaire highlights articles featured in the August 1st and August 15th issues of Circulation Research. This Episode also features a discussion with Abigail Ajanel, Dr Robbie Campbell and Dr Frederik Denorme about their study, Mitochondrial Calcium Uniporter Regulates ITAM-Dependent Platelet Activation.   Article highlights: Lan, et al. TRIM16 Exacerbates Vascular Calcification Zhang, et al. HADHA Lactylation in Septic Myocardial Depression Li, et al. AR Links to CVMs Baudel, et al. Vascular Panx1 in Diabetic Hyperglycemia

This month on Episode 74 of Discover CircRes, host Cindy St. Hilaire highlights articles featured in the June 20th and July 4th issues of Circulation Research. This Episode also features a discussion with the finalists for the 2025 BCVS Outstanding Early Career Investigator Award.   Article highlights: Kimura, et al. Novel Genetic Mouse Model of Aortic Dissection Getaneh, et al. Aspirin Non-Responsiveness in Preeclampsia Introduction to the Compendium on Cardiopulmonary Disease and Exercise: Molecular to Clinical Mechanisms