Advertise on podcast: Discover CircRes

This month on Episode 80 of Discover CircRes, host Cindy St. Hilaire highlights articles featured in the January 2nd and January 16th issue of Circulation Research. This Episode also features a discussion with Dr Colin Evans and Dr You-Yang Zhao about their study, The Unexpected Protective Role of Thrombosis in Lung Injury via Endothelial ALOX15.   Article highlights: Viskadourou, et al. Endothelial REST in Atherosclerosis Torre, et al. Silencing the Chronotropic Heart Rate Response Chen, et al. Histone Lactylation and Cardiac Hypertrophy Vázquez-Reyes, et al. Diurnal Neutrophil Function Drives Stroke Outcome

This month on Episode 79 of Discover CircRes, host Cindy St. Hilaire highlights articles featured in the December 5th issue of Circulation Research. This Episode also features a discussion with Dr Nobuaki Fukuma and Dr Emily Tsai from Columbia University Vagelos College of Physicians and Surgeons about their study, Cardiomyocyte GC1 Mediates Estrogenic Angiogenesis in Right Heart Remodeling.   Article highlights: Hamilton, et al. RyR2 Hyperactivity Remodels Mitochondria Singhal, et al. TRIB3 Activation Impairs Efferocytosis Tsai, et al. YAP Induces Glycolysis to Drive Fibroinflammation

This month on Episode 78 of Discover CircRes, host Cindy St. Hilaire highlights articles featured in the October 24th and November 7th issues of Circulation Research. This Episode also features a discussion with Thomas Hund and  Drew Nassal from the Ohio State University about their study, The βIV-Spectrin/STAT3 Complex Regulates the Orientation of Cardiac Hypertrophic Growth.   Article highlights: Dhawan, et al. Macrophage DNases Clear Tissue NETs Pakkiriswami, et al. LV and RV Responses to Elevated Mitochondrial Ca2+ Liu, et al. CCL21 Enhances Platelet Activation Morales, et al. Vascular Niches and Cardiac Aging

This month on Episode 76 of Discover CircRes, host Cindy St. Hilaire highlights articles featured in the August 29th and September 12th issues of Circulation Research. This Episode also features a discussion with Drs Swapnil Sonkusare and Mani Kuppusamy about their manuscript, Paracrine Smooth Muscle-to-Endothelial Signaling via TNF Elevates Blood Pressure in Obesity.   Article highlights: Tombor, et al. Immunomodulatory Endothelial Cells After Heart Attack Du, et al. CAR-Ms Engineered In Vivo for Attenuating MIRI Pauza, et al. MC4R Activates Carotid Body in Hypertension Cai, et al. Lkb1 KO in PVAT Drives Aortic Aneurysm Formation

This month on Episode 75 of Discover CircRes, host Cindy St. Hilaire highlights articles featured in the August 1st and August 15th issues of Circulation Research. This Episode also features a discussion with Abigail Ajanel, Dr Robbie Campbell and Dr Frederik Denorme about their study, Mitochondrial Calcium Uniporter Regulates ITAM-Dependent Platelet Activation.   Article highlights: Lan, et al. TRIM16 Exacerbates Vascular Calcification Zhang, et al. HADHA Lactylation in Septic Myocardial Depression Li, et al. AR Links to CVMs Baudel, et al. Vascular Panx1 in Diabetic Hyperglycemia

This month on Episode 74 of Discover CircRes, host Cindy St. Hilaire highlights articles featured in the June 20th and July 4th issues of Circulation Research. This Episode also features a discussion with the finalists for the 2025 BCVS Outstanding Early Career Investigator Award.   Article highlights: Kimura, et al. Novel Genetic Mouse Model of Aortic Dissection Getaneh, et al. Aspirin Non-Responsiveness in Preeclampsia Introduction to the Compendium on Cardiopulmonary Disease and Exercise: Molecular to Clinical Mechanisms

This month on Episode 73 of Discover CircRes, host Cindy St. Hilaire highlights articles featured in the May 23rd and June 6th issues of Circulation Research. This Episode also includes a discussion with Dr Jae Min Cho and Tzung Hsiai, about their study, Habitual Exercise Modulates Neuroimmune Interaction to Mitigate Aortic Stiffness.   Article highlights: Interorgan Crosstalk in Heart Failure and Cardiometabolic Diseases: A Compendium He, et al. NEP in Placental EVs Triggers Hypertension in PE Dennis, et al. FoxO1-zDHHC4-CD36 S-Acylation Axis in Diabetes

This month on Episode 72 of Discover CircRes, host Cindy St. Hilaire highlights four articles featured in the April 25th and May 9th issues of Circulation Research. This Episode also includes a discussion with Dr Sarah Costantino and Dr Francesco Paneni from University Hospital Zurich about their study, Chromatin Rewiring by SETD2 Drives Lipotoxic Injury in Cardiometabolic HFpEF     Article highlights: Laudette, et al. PCSK9 and Mitochondrial Cholesterol in Heart Yang, et al. Srsf3 Limits AS by Lengthening 3′ UTRs of mtARSs Li, et al.  CircCDYL Contributes to Cardiac Hypertrophy Zhakeer, et al. Treg Cells Regulate Pulmonary Venous Remodeling

This month on Episode 71 of Discover CircRes, host Cindy St. Hilaire highlights three articles featured in the March 28th and April 11th issues of Circulation Research. This Episode also includes a discussion with Dr Magali Noval Rivas and Dr Prasant Jena from Cedars-Sinai Medical Center about their study, Intestinal Microbiota Contributes to the Development of Cardiovascular Inflammation and Vascular in Mice.   Article highlights: Han, et al. PRL2 Dephosphorylates AMPKα2 in Heart Perelli, et al. TAX1BP3 and Arrhythmogenic Cardiomyopathy Lalaguna, et al. Overexpression of Wild Type TMEM43 Improves ARVC5 Liu, et al. NR4A1 Inhibits Platelet Function

This month on Episode 70 of Discover CircRes, host Cindy St. Hilaire highlights three articles featured in the February 28th issue of Circulation Research and the Compendium on Lifelong Care in Women: Applying a Sex- and Gender-Lens to Practice in the March 14th issue. This Episode also includes a discussion with Dr Matt Rossman and Sanna Darvish from the University of Colorado, Boulder about their study, Preservation of Vascular Endothelial Function in Late Onset Postmenopausal Women.   Article highlights: Huang, et al. Targeting CXCR3 in ICI-Mediated Myocarditis Ju, et al. RIC-Enhanced Efferocytosis on Stroke Recovery Halmos, et al. Cholesterol Efflux Pathways Control SMC Function Compendium on Lifelong Care in Women: Applying a Sex- and Gender-Lens to Practice  

This month on Episode 69 of Discover CircRes, host Cindy St. Hilaire highlights four articles featured in the January 31st and February 14th issues of Circulation Research. This Episode also includes a discussion with Dr Frank Conlon and graduate student Ike Emerson about their study, X Chromosome-Linked MicroRNAs Regulate Sex Differences in Cardiac Physiology.   Article highlights: Huang, et al. Vps4a Safeguards Plasma Membrane Integrity Liu, et al. PPM1B Deubiquitination Promotes Arterial Stiffness Muralitharan, et al. GPR41/43 and Blood Pressure Park, et al. Ferroptosis and Its Consequences in Preeclampsia

This month on Episode 68 of Discover CircRes, host Cindy St. Hilaire highlights four articles featured in the January 3rd and January 17th issues of Circulation Research. This Episode also includes a discussion with Drs Gianluigi Condorelli and Marinos Kallikourdis about their study Autoimmune-like Mechanism in Heart Failure Enables Preventative Vaccine Therapy.   Article highlights: Yoshida, et al. FAP Vaccine Improves Cardiac Fibrosis Johansen, et al. TCF21 and Cardiac Fibrosis Pabon, et al. Endothelial METAP1 in Preeclampsia Mutchler, et al. ET-3/ETBR, Immune Cells, and Kidney Lymphatics

This month on Episode 67 of Discover CircRes, host Cindy St. Hilaire highlights articles featured in the December 6th issues of Circulation Research. This Episode also includes a discussion with Drs Jesse Rowley and Shancy Jacob about their study, Mitofusin-2 Regulates Platelet Mitochondria and Function.   Article highlights: Bardhan, et al. Sex Specific Roles of Microbiota in Hypertension Ma, et al. Kindlin-2 LLPS Controls Vascular Stability Wang, et al. CAR-Ms Alleviate Myocardial I/R Injury

This month on Episode 66 of Discover CircRes, host Cindy St. Hilaire highlights articles featured in the October 25th and November 8th issues of Circulation Research. This Episode also includes a discussion with Dr Jil Tardiff and Dr Melissa Lynn about their study, Arg92Leu-cTnT Alters the cTnC-cTnI Interface Disrupting PKA-Mediated Relaxation.   Article highlights: Lou, et al. Visualizing irAEs in Atherosclerosis Yoshii, et al. Defective Mitophagy Response in HFpEF Heart Zeller, et al. Shear Stress Dissociates C-Reactive Protein Chen, et al. EPHB4-RASA1 Regulation of Lymphatic Valvulogenesis