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View the show notes on the episode webpage: https://www.bradyholmer.com/pod/46 My guest on episode 46 of the podcast is Dr. Annet Kirabo. Dr. Kirabo is an Assistant Professor of Medicine in the Division of Clinical Pharmacology in the Department of Medicine at Vanderbilt University Medical Center. She obtained her PhD from the Department of Physiology and Functional Genomics at the University of Florida College of Medicine. If you enjoy this podcast and would like a way to support my work, the best way to do this is by becoming a supporter on Patreon, where you can pledge a monthly donation of any amount. You can find more information about becoming a Patreon supporter by going to patreon.com/bradyholmer or finding the link in the show notes. You can also support the podcast through a one-time donation using the links on my website. Just go to bradyholmer.com/donate or check the link in the show notes for more information. Last but not least, if you enjoy any of the topics that appear on this podcast, you will love my Substack and weekly newsletter that I send out every Friday called Physiology Friday. To sign up to receive occasional blog posts and my weekly email newsletter, go to bradyholmer.substack.com/about. If you sign up, I hope you enjoy!   Links Episode webpage: https://www.bradyholmer.com/pod/46 Watch the video of this episode (Patreon exclusive until 6/20/22): https://www.patreon.com/posts/67694663  Follow Dr. Kirabo on Twitter @annetkiraboc1 List of Dr. Kirabo’s scientific publications on PubMed: https://pubmed.ncbi.nlm.nih.gov/?term=%28Kirabo+Annet%5Bauthor%5D%29+AND+Vanderbilt+University%5BAffiliation%5D&sort=date  Read Dr. Kirabo et al.’s paper: “Recent advances in modulation of cardiovascular diseases by the gut microbiota”: https://drive.google.com/file/d/1vIZtuVF1n8C4NbsGGm-Rdk8gFtw47Cdl/view?usp=sharing Support the podcast on Patreon: https://www.patreon.com/bradyholmer Other support options: https://www.bradyholmer.com/donate   Listen on Apple Podcasts: https://podcasts.apple.com/us/podcast/science-chill/id1494739189?cc=us&id=1494739189&ign-itscg=30200&ign-itsct=podcast_box&urlDesc=%2Fscience-chill Listen on Spotify: https://open.spotify.com/show/2ilq7P9OBAiqrxk4Ac4WQg Subscribe to my weekly newsletter Physiology Friday: https://bradyholmer.substack.com/about 10% Discount for On brand running shoes when you buy through Suda’s Fit Foot: https://www.sudasfitfoot.com/shop

My guest on episode 45 of the Science & Chill podcast is Ingri Pauline. Ingri is a weightlifting coach, National Strength and Conditioning Association-certified strength and conditioning specialist, and certified nutrition coach. Ingri is unique in that she only works with women, specializing in fitness and nutrition during different transition periods during women’s lives including fertility, pregnancy, postpartum, perimenopause, and postmenopause. Ingri uses a concept called cycle syncing to optimize the work productivity and athletic performance of her clients, which involves strategically using hormonal fluctuations during phases of a woman’s menstrual cycle to enhance work output. The topic of cycle syncing dominates most of this episode and there is really some fascinating information to be gained here — not just for women, but also for their partners. Trust me, I was taking dutiful mental notes during this entire episode. If you’re not a woman, you’re probably thinking that this episode may not apply to you, but trust me, there is a ton of great information to be gained from Ingri that men, women, or any other partner to a woman can use to support her. Ingri is also just incredibly knowledgeable about strength, conditioning, and nutrition, and we chat plenty about these topics during our interview. If you enjoy this podcast and would like a way to support my work, the best way to do this is by becoming a supporter on Patreon, where you can pledge a monthly donation of any amount. You can find more information about becoming a Patreon supporter by going to patreon.com/bradyholmer or finding the link in the show notes. You can also support the podcast through a one-time donation using the links on my website. Just go to bradyholmer.com/donate or check the link in the show notes for more information. Last but not least, if you enjoy any of the topics that appear on this podcast, you will love my Substack and weekly newsletter that I send out every Friday called Physiology Friday. To sign up to receive occasional blog posts and my weekly email newsletter, go to bradyholmer.substack.com/about. If you sign up, I hope you enjoy!   Links Twitter: @IngriPauline  Instagram: @ingripauline Website: IngriPaulineAthletics.com   Podcast links Episode webpage: https://www.bradyholmer.com/pod/45 Watch this episode on YouTube: https://www.youtube.com/channel/UCR60b_GvhAvSApVjYqmqi2Q Support the podcast on Patreon: https://www.patreon.com/bradyholmer   Other support options: https://www.bradyholmer.com/donate   Listen on Apple Podcasts: https://podcasts.apple.com/us/podcast/science-chill/id1494739189?cc=us&id=1494739189&ign-itscg=30200&ign-itsct=podcast_box&urlDesc=%2Fscience-chill Listen on Spotify: https://open.spotify.com/show/2ilq7P9OBAiqrxk4Ac4WQg Subscribe to my weekly newsletter Physiology Friday: https://bradyholmer.substack.com/about 10% Discount for On brand running shoes when you buy through Suda’s Fit Foot: https://www.sudasfitfoot.com/shop

My guest today is Dr. Heather Vincent. Dr. Vincent is the Director of Research and Director of the UF Health Sports Performance Center (SPC) in the Department of Physical Medicine and Rehabilitation (PMR) in Gainesville Florida. She is an active researcher of the health benefits of exercise, using physical activity to prevent injury and fight diseases like obesity and osteoarthritis. She is active at the national level with organizations including the American College of Sports Medicine and the Osteoarthritis Research Society International. Since 2008, the SPC has been serving people from all over the USA and internationally. They are quite literally one of the premier sports performance and rehab centers in the entire country, and this is something I can attest to on a personal level. This episode of the podcast was recorded on the back end of my visit to the SPC to undergo a comprehensive running gait and form analysis as well as a long discussion with Dr. Vincent on how I can improve my running form for better health and performance. Unfortunately, I have been a frequent visitor to see Dr. Heather Vincent’s husband — who leads the running medicine clinic at the University of Florida — to deal with multiple running-related injuries. I have also done another previous gait assessment with Dr. Vincent and her team back in 2018 when coming back from injury. The precision and attention they gave me were unprecedented, and the amount I learned from Dr. Vincent during both of my visits to the SPC is incredible. Getting to speak with her about my results and then delve into a good deal of running-related topics was an extra special treat. In the first 45 minutes of this episode, Dr. Vincent and I review the results of my running gait analysis. For this reason, I highly encourage you to check out the video of this episode on YouTube or find the corresponding video and images in the show notes to this episode, as it will make following along with what we are saying much easier. But no worries, if you’re unable to watch, there is still a lot of great information to be gleaned from listening to our chat about my running form. In the second half of the podcast, we talk about healthy running habits, how runners can optimize their form for injury reduction and faster and healthier running, and how to select the best running shoes for you. Dr. Vincent also answers some of the questions posed on Twitter by my audience on several running-related topics. If you are a runner or just interested in improving your own biomechanics and strength, you are going to love this episode. If you enjoy this podcast and would like a way to support my work, the best way to do this is by becoming a supporter on Patreon, where you can pledge a monthly donation of any amount. You can find more information about becoming a Patreon supporter by going to patreon.com/bradyholmer or finding the link in the show notes. You can also support the podcast through a one-time donation using the links on my website. Just go to bradyholmer.com/donate or check the link in the show notes for more information. If you are looking for an awesome new pair of running shoes, my good friend (and incredible runner) Betsy Suda (Suda’s Fit Foot) is offering a 10% discount for On running shoes. Check out her business by going to www.sudasfitfoot.com/shop and enter the code CHILL10 to take advantage of this offer! Last but not least, if you enjoy any of the topics that appear on this podcast, you will love my Substack and weekly newsletter that I send out every Friday called Physiology Friday. To sign up to receive occasional blog posts and my weekly email newsletter, go to bradyholmer.substack.com/about. If you sign up, I hope you enjoy!   Links Watch the video of this episode on Patreon Google drive link to PDF of scientific papers published by the UF Sports Performance Center UF SPC Follow Dr. Vincent on Twitter Podcast links Support the podcast on YouTube Oth

My guest on this episode is Dr. Brad Stanfield. Dr. Stanfield is a medical doctor trained in New Zealand who has a particular interest in optimizing healthspan and lifespan through the use of nutritional and lifestyle interventions. Dr. Stanfield is also quite the expert in supplements with the potential to enhance healthspan and lifespan and, as you will hear in our conversation, approaches supplementation in an incredibly evidence-based way that I really admire.  In this episode, we talk about what healthy aging and lifespan are, the best ways to promote healthspan and delay aging, the supplements that Dr. Stanfield recommends or is excited about, the supplements that he has stopped taking and the various reasons why — a very interesting part of our conversation, as well as some of the recent controversies in longevity research which Dr. Stanfield has played a role in bringing to the public eye (along with my previous guest Dr. Charles Brenner). I first became aware of Dr. Stanfield after stumbling upon his awesome YouTube channel where he does comprehensive breakdowns of aging research and supplements. I really encourage you to give him a follow on YouTube and other social media, because he’s producing great content. If you enjoy this podcast and would like to support it, there are several ways to do so. The first way is by becoming a supporter of Patreon. With Patreon, you can support the podcast with a monthly donation at any level you’d like. You can start showing your support right now by going to patreon.com/bradyholmer or checking the shownotes for a link to my Patreon page. You can also make a one-time donation to help support the podcast through PayPal or Venmo. These support options can be found on my website by going to bradyholmer.com/donate. There’s also a link in the shownotes to the support page.  Finally, checking out the podcast sponsors is also a fantastic way to show your support. There are two partners for today’s podcast, both of which are products I use frequently and absolutely love. The first is LMNT electrolyte drink mix. LMNT is a sugar-free, carbohydrate-free and tasty drink mix containing scientifically-based amounts of sodium, potassium, and magnesium. The single serve packets are great to add to water for any time around a workout or just to have throughout the day. I’m routinely using about 3 of these each day. LMNT comes in a variety of flavors including citrus salt, raspberry, and watermelon. You can try a free 8 pack sampler of LMNT by going to drinklmnt.com/scienceandchill or checking the shownotes for a link to this special offer. I’ve also partnered with health via modern nutrition (HVMN) to bring a special offer for my audience on their brand-new ketone IQ ketone drink. Ketones are sometimes called the “fourth fuel” and can be used by our muscles, heart, and brain for energy. With exogenous ketone drinks like ketone IQ, you can rapidly elevate your blood ketones and put your body into a state of ketosis. Studies have found — and I have experienced — that taking ketones can help with mental performance and clarity, athletic performance, and maintain energy levels throughout the day.  If you have not yet tried ketones, I really encourage you to give ketone IQ a try. You can get 10% off your order of ketone IQ by going to their website using the link in the shownotes and entering the code BRADY10 at checkout. Again, use the link in the shownotes to learn more about ketone IQ and when you order, enter BRADY10 at checkout for 10% off your order. Last but not least, if you enjoy my podcast, then you may also enjoy some of the writing that I publish on a weekly basis, which includes my weekly newsletter that I send out every Friday called Physiology Friday. If you’d like to check out my writing and subscribe to receive my weekly posts, please visit bradyholmer.substack.com. You can also find a link in the shownotes.   Links Dr. Stanfield's website: htt

In this podcast clip from episode 42, Dr. Charles Brenner explains metabolism.   Listen to the full episode HERE.

In this podcast clip from episode 42, Dr. Charles Brenner explains biological aging and ponders whether or not we can significantly extend human lifespan.   Listen to the full episode HERE.

In this podcast clip from episode 42, Dr. Charles Brenner discusses his criticisms of the aging field and some of the main problems with a recent book about why humans age and they don't have to.   Listen to the full episode HERE.

My guest on episode 42 of the podcast is Dr. Charles Brenner Dr. Brenner is the Alfred E Mann Family Foundation Chair in Diabetes and Cancer Metabolism at City of Hope National Medical Center.  In 2004, Brenner discovered nicotinamide riboside (NR) to be a vital precursor of nicotinamide adenine dinucleotide (NAD+), which is made available by nicotinamide riboside kinases (Nrks) that are conserved between yeast and humans. In 2007, Dr. Brenner’s lab discovered a second pathway by which NR is converted to NAD+ and showed that NR can extend the lifespan of yeast cells by virtue of elevating NAD+ levels and increasing the activity of the NAD+-dependent Sir2 enzyme. In the past decade, Dr. Brenner has made multiple seminal contributions to NAD+ metabolism, which include engineering a yeast strain to convert inexpensive NAD+ precursor vitamins into NR, solving the crystal structure of human Nrk1, developing the methods for quantitative NAD+ metabolomics, and demonstrating the activity of oral NR in animal models of fatty liver disease; obesity; type 2 diabetes; diabetic and chemotherapeutic neuropathy; heart failure; and central brain injury. Dr. Brenner also led the first clinical trial of NR, which established safe oral availability in humans. He is currently focusing on the maternal and neonatal effects of oral NR and translating animal discoveries into evidence-based safe, human clinical practice for human conditions of metabolic stress. Dr. Brenner is clearly a well-credentialed scientist, but my main impetus for inviting him to come on the podcast is his recent public criticisms of the longevity field. In particular, Dr. Brenner has several recent posts in which he has directly called out prominent longevity scientist Dr. David Sinclair for what Dr. Brenner describes as spreading misinformation regarding what we know about aging and whether or not we can slow or reverse aging. We spend the last 20 minutes or so of the podcast discussing his critiques and where he believes scientists in the longevity field may be overstepping. Other topics that we get into include some basics on human metabolism, nicotinamide adenine mononucleotide (also known as NAD) and the importance of the NAD system in physiology, what types of things perturb the NAD system and how this may contribute to diseases and aging, and ways we might be able to boost the NAD system through diet and supplementation. I will say that at times, we got pretty technical in this podcast, and Dr. Brenner gets into some of the more complex biochemistry surrounding metabolism and the NAD system. But I really encourage you to listen to everything we chat about, because Dr. Brenner is such an eloquent speaker about these topics and I think that even if some concepts are higher level, you’ll learn a lot about biology and physiology through what he has to say — I surely did.  If you enjoy this podcast and would like to support it, there are several ways to do so. The first way is by becoming a supporter of Patreon. With Patreon, you can support the podcast with a monthly donation at any level you’d like. You can start showing your support right now by going to patreon.com/bradyholmer or checking the show notes for a link to my Patreon page. You can also make a one-time donation to help support the podcast through PayPal or Venmo. These support options can be found on my website by going to bradyholmer.com/donate. There’s also a link in the show notes to the support page. Finally, checking out the podcast sponsors is also a fantastic way to show your support. There are two partners for today’s podcast, both of which are products I use frequently and absolutely love. The first is LMNT electrolyte drink mix. LMNT is a sugar-free, carbohydrate-free and tasty drink mix containing scientifically-based amounts of sodium, potassium, and magnesium. The single serve packets are great to add to water for any time around a workout or just to have througho

In this Science & Chill podcast clip from episode 41 (Dr. Kieran Clarke and Brian McMahon from deltaG Ketones), Dr. Clarke explains ketosis and describes how the body uses endogenous and exogenous ketones as an energy source.   Listen to the full interview HERE.

In this clip from episode 41 of the Science & Chill podcast (Dr. Kieran Clarke and Brian McMahon from deltaG Ketones), Dr. Clarke discusses the recent literature on exogenous ketones and exercise performance, as well as potential applications for exogenous ketones for recovery and preventing overtraining.   Listen to the full episode HERE.

In this episode of the Science & Chill podcast, I interview Dr. Kieran Clarke and Brian McMahon of T delta S, a company who sells deltaG ketones, an exogenous ketone ester. Dr. Kieran Clarke is a legend in the ketone world. Born in Adelaide, South Australia, Kieran Clarke studied for her undergraduate BSc (Hons) in Biological Sciences at Flinders University. She obtained her PhD in Biochemistry at the University of Queensland before taking a post-doctoral fellowship at Harvard University Medical School Nuclear Magnetic Resonance Laboratory between 1985 and 1989. She has over 25 years research experience in magnetic resonance (MR) imaging and spectroscopy to non-invasively measure human cardiac, brain and skeletal muscle function and energy metabolism. We are also joined in this episode by Brian McMahon. Brian is the Chief of Staff at T delta S, and it was awesome to have him on the interview to give his perspective on the market for exogenous ketone ester, what makes T delta S special among the many available ketone products, and how he got into this area of health and performance. Even if you aren’t fully up to speed on the biochemistry of ketones, I think you will enjoy this episode. Dr. Clarke and Brian do a fantastic job of describing the science of ketosis and their product, and even though I had some prior knowledge in this area, I came away from this interview with much more knowledge and interest in ketone esters than I previously had. Before I go, I would like to mention that there are several ways that you can support this podcast if you have the means to do so. The first and best way it to become a supporter on Patreon, where you can pledge a monthly donation of your choosing. Thanks so much to all the current supporters who make this podcast possible. You can also support this podcast by making a one-time donation through PayPal. You can find a link in the show notes to show your support in this way. Finally, you can support my work by purchasing product sponsors of the show. Right now, we are supported by LMNT electrolyte drink mix, a tasty and effective electrolyte supplement that I use multiple times per day to fuel and recover from workouts. I promise that you’ll love this product and encourage you to try some for yourself. You can go to drinkLMNT.com/scienceandchill to claim a free sample pack if you haven’t done so already, but you can also use the link to replenish your stock of salt. Without further ado, please enjoy my conversation with Dr. Kieran Clarke and Brian McMahon. Links deltaG Ketones Follow deltaG Ketones on Twitter (@deltaGKetones) and Instagram (@deltag.ketones) Link to peer-reviewed literature on delta G Support Science & Chill on Patreon Make a one-time donation to the podcast on PayPal Subscribe to my weekly email newsletter Check out our sponsor: LMNT electrolyte drink mix!   Check out the complete episode shownotes, including the transcript, on the episode web page!

My guest today is Mark Huston. Mark is a doctoral candidate at Loughborough University. Mark earned his Bachelors of Sport and Exercise Science at Liverpool John Moores University, where he also obtained his Master’s of science in sports nutrition. I invited Mark to come on the podcast to talk about his current research into the effects of low energy availability on health and performance in humans. Specifically, we discuss low energy availability as it relates to bone health and the risk of bone stress injury in athletes. Mark has recently published a fantastic review article on the subject in the journal Sports Medicine, where he discusses the effects of low energy availability in weight-bearing endurance athletes as well as potential countermeasures to increase bone strength and bone health in these athletes. Our discussion starts with some basic background into bone health and stress injuries, and then we dive in to defining low energy availability and how this condition affects bone health and other aspects of health in athletes. We then transition to talking about high-impact exercise as a novel countermeasure to increase bone health in athletes, and then end talking a bit about the role of nutrition and, specifically, protein and micronutrients, in bone health. I really enjoyed this conversation with Mark and to be honest, my invite was a bit selfish in nature. I am all too familiar with bone stress injuries, actually having suffered multiple lower limb stress fractures, and even one hip fracture, over the course of the past few years. Whether this is due to low energy availability, a high amount of weight bearing exercise in the form of running, or a combination of both, I’m not quite sure, but a recent DEXA scan did reveal to me that my bone health was far from optimal and needed some intervention. This has been something on my mind for quite a while as I try to prevent further injury and set myself up for injury-free activity in the future. So I also wanted to pick Mark’s mind on some of my personal struggles with bone health and get some advice on tools that I might be able to implement to enhance my own bone health.   Links - Follow Mark on Twitter @MarkJHutson - Check out Mark’s research on Research Gate - Read Mark’s review article: Effects of Low Energy Availability on Bone Health in Endurance Athletes and High-Impact Exercise as A Potential Countermeasure: A Narrative Review - Listen on Apple Podcasts - Listen on Spotify - Support the podcast on Patreon - Other support options - Subscribe to the Physiology Friday newsletter - Check out LMNT electrolytes