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Dr. Aleksandra Gajer spent years in emergency medicine then shifted her focus toward helping people get ahead of health problems—not just treat them once they appear. She’s developed a practice that covers all aspects of longevity. Today we chat about metabolic health, hormones, lifestyle, and what it really means to take a more personalized approach to feeling your best. And we’re getting into some of the hottest topics in health right now: GLP-1 medications, peptides, hormone therapy, biological age, weight loss, and even aesthetics. Are these tools the answer or are we sometimes focusing on one piece of the puzzle while missing the bigger picture? In this episode, Dr. Gajer shares her perspective on what it means to strive for health span rather than lifespan and why the goal should be about more than a number on the scale or a number on your biological age test. Today on The Lab Report: 3:40 Meet Dr. Aleksandra Gajer and hear about her journey from the ER 8:05 Approaching the peri-menopausal/menopausal woman 12:20 Biological vs. chronological age 15:00 GLP-1’s and peptides 24:10 Aesthetics and aging skin 26:25 Gajer’s practice (link below) 27:15 The Fireball         Additional Resources: The Gajer Practice Genova Connect  ***Use promo code TheLabReport20 for 20% off your purchase*** Subscribe, Rate, & Review The Lab Report Thanks for tuning in to this week’s episode of The Lab Report, presented by Genova Diagnostics, with your hosts Michael Chapman and Patti Devers. If you enjoyed this episode, please hit the subscribe button and give us a rating or leave a review. Don’t forget to visit our website, like us on Facebook, follow us on Twitter, Instagram, and LinkedIn. Email Patti and Michael with your most interesting and pressing questions on functional medicine: [email protected]. And, be sure to share your favorite Lab Report episodes with your friends and colleagues on social media to help others learn more about Genova and all things related to functional medicine and specialty lab testing. To find a qualified healthcare provider to connect you with Genova testing, or to access select products directly yourself, visit Genova Connect. Disclaimer: The content and information shared in The Lab Report is for educational purposes only and should not be taken as medical advice. The views and opinions expressed in The Lab Report represent the opinions and views of Michael Chapman and Patti Devers and their guests. See omnystudio.com/listener for privacy information.

Dr. Shilpa Saxena is a longtime leader and educator in functional and integrative medicine and Chief Medical Officer at Forum Health. Dr. Saxena’s approach to healing involves active listening and true connection to ensure patients are heard. She’s taught many of us over the years with her light-hearted metaphors and analogies that framed our understanding of complex topics – including the gut microbiome’s role in systemic health. In today’s episode, whether you’re a clinician or simply curious about the connection between the gut and overall health, this conversation with Dr. Shilp Saxena offers an engaging look at where integrative and functional medicine has been, where it’s going, and why the gut may be at the center of it all. Today on The Lab Report: 3:30 Dr. Shilpa Saxena’s path to functional medicine and the importance of gut health 10:34 The Front Door to the House of Health – skin, immunity, brain, hormones 15:20 Explaining the microbiome to patients- gated community metaphor 21:00 When to order stool testing, therapeutic options, tying it all together 27:30 Cardiometabolic health, behavior change, active listening 31:30 Virtual care vs. on-sight office visits 34:40 Approach to BHRT 39:10 Evolving with Artificial Intelligence 42:00 The vision behind Forum Health 46:50 The Fireball   Additional Resources: Forum Health Subscribe, Rate, & Review The Lab Report Thanks for tuning in to this week’s episode of The Lab Report, presented by Genova Diagnostics, with your hosts Michael Chapman and Patti Devers. If you enjoyed this episode, please hit the subscribe button and give us a rating or leave a review. Don’t forget to visit our website, like us on Facebook, follow us on Twitter, Instagram, and LinkedIn. Email Patti and Michael with your most interesting and pressing questions on functional medicine: [email protected]. And, be sure to share your favorite Lab Report episodes with your friends and colleagues on social media to help others learn more about Genova and all things related to functional medicine and specialty lab testing. To find a qualified healthcare provider to connect you with Genova testing, or to access select products directly yourself, visit Genova Connect. Disclaimer: The content and information shared in The Lab Report is for educational purposes only and should not be taken as medical advice. The views and opinions expressed in The Lab Report represent the opinions and views of Michael Chapman and Patti Devers and their guests. See omnystudio.com/listener for privacy information.

Firefighters put their health on the line every day. But the risks they face don’t end when the fire is out. From smoke and diesel exhaust to extreme heat, chronic stress, disrupted sleep, and demanding shift schedules, the fire service can place tremendous strain on the body. In this episode, we sit down with Jessica Meyers, MPAP, PA-C, physician assistant and founder of FIREPROOF Wellness, to explore why firefighters may need a different approach to healthcare and why some of the earliest signs of physiological stress can be missed by traditional screening. Jessica Meyers shares what she has learned from working one-on-one with firefighters and why identifying changes in metabolic, hormonal, and nutritional health early may be key to improving recovery, resilience, and long-term health. Whether you’re a firefighter, a first responder, or someone who wants to better understand the unique health challenges of the fire service, this episode offers an eye-opening look at moving from reactive healthcare to prevention-focused care built specifically for those who protect others. Today on The Lab Report: 5:00 Meet Jessica Meyers and learn how her husband inspired her journey 8:50 Firefighters’ health is uniquely challenged 11:20 Dealing with so many stressors 14:10 Hormonal health 18:30 HPA axis and recovery 20:30 NutrEval – oxidative stress and nutrition 26:30 FIREPROOF Wellness 27:30 The Fireball Additional Resources: FIREPROOF Wellness Subscribe, Rate, & Review The Lab Report Thanks for tuning in to this week’s episode of The Lab Report, presented by Genova Diagnostics, with your hosts Michael Chapman and Patti Devers. If you enjoyed this episode, please hit the subscribe button and give us a rating or leave a review. Don’t forget to visit our website, like us on Facebook, follow us on Twitter, Instagram, and LinkedIn. Email Patti and Michael with your most interesting and pressing questions on functional medicine: [email protected]. And, be sure to share your favorite Lab Report episodes with your friends and colleagues on social media to help others learn more about Genova and all things related to functional medicine and specialty lab testing. To find a qualified healthcare provider to connect you with Genova testing, or to access select products directly yourself, visit Genova Connect. Disclaimer: The content and information shared in The Lab Report is for educational purposes only and should not be taken as medical advice. The views and opinions expressed in The Lab Report represent the opinions and views of Michael Chapman and Patti Devers and their guests. See omnystudio.com/listener for privacy information.

Most people don't think about their bones until something breaks—but by then, it may be too late. Dr. John Neustadt literally wrote the book on this topic and challenges everything you thought you knew about bone health. He offers everyday habits that can protect you from fracture, discusses the role of nutrition, exercise, hormones, and even commonly prescribed medications that can directly affect your bones. Whether you're looking to stay active as you age, have a family history of osteoporosis, or simply want to prevent future health problems, this episode is packed with practical advice you can start using today. Drawing from his newly expanded book, Fracture-Proof Your Bones, Dr. John Neustadt shares the latest advances in bone health research. This is an empowering discussion filled with actionable advice for clinicians and health-conscious listeners alike—proving that it's never too early, or too late, to invest in stronger bones and a healthier future. Today on The Lab Report: 3:15 Meet Dr. John Neustadt   5:20 Is Osteoporosis just part of aging? 6:45 Bone is complex, living tissue 8:10 Medications affect bone health/remodeling 12:00 Catabolic physiology and stressors 13:45 Bisphosphonates - fracture risk vs. bone density 21:05 Best predictor of fracture 24:05 Personalized treatment approaches 27:15 Optimizing hormones and Hormone replacement therapy 30:25 Vitamin K and its many forms 38:40 Diet first vs. supplements 40:10 NBI supplement company 43:00 The Fireball   Additional Resources: NBI Health Fracture-Proof Your Bones - Expanded and Updated Edition Delivering Health Podcast Subscribe, Rate, & Review The Lab Report Thanks for tuning in to this week’s episode of The Lab Report, presented by Genova Diagnostics, with your hosts Michael Chapman and Patti Devers. If you enjoyed this episode, please hit the subscribe button and give us a rating or leave a review. Don’t forget to visit our website, like us on Facebook, follow us on Twitter, Instagram, and LinkedIn. Email Patti and Michael with your most interesting and pressing questions on functional medicine: [email protected]. And, be sure to share your favorite Lab Report episodes with your friends and colleagues on social media to help others learn more about Genova and all things related to functional medicine and specialty lab testing. To find a qualified healthcare provider to connect you with Genova testing, or to access select products directly yourself, visit Genova Connect. Disclaimer: The content and information shared in The Lab Report is for educational purposes only and should not be taken as medical advice. The views and opinions expressed in The Lab Report represent the opinions and views of Michael Chapman and Patti Devers and their guests. See omnystudio.com/listener for privacy information.

What happens when a mother’s determination to find answers meets a physician dedicated to uncovering the root causes behind autism and developmental challenges? In this powerful episode, autism advocate Heather Acquavella of Theo’s Voice joins renowned functional medicine specialist Dr. Jared Skowron to share the remarkable journey of her son, Theo. Together they discuss the turning points that led them beyond conventional approaches, the testing and discoveries that helped unlock new possibilities, and the lessons they’ve learned along the way. Today’s episode is an honest conversation about advocacy, persistence, and a search for answers beyond a conventional medicine approach. Our guests share practical advice for families navigating autism and developmental concerns including how to cut through overwhelming information, trust parental instincts, and balance hope with realistic expectations. Heather Acquavella shares the mission behind Theo’s Bridge Foundation and her growing community of parents seeking support and answers, while Dr. Jared Skowron offers insights into the most common challenges families face and the evolving future of autism care. Whether you’re a parent, caregiver, practitioner, or advocate, this episode delivers inspiration, actionable insights, and a powerful reminder that every child’s journey is unique. Today on The Lab Report: 4:00 Meet Dr. Jared Skowron and Heather Acquavella 5:35 Theo’s story and Heather’s determination 9:15 Skowron’s pioneering story in helping autistic children 11:00 Working together for answers, sharing the story on TikTok 17:55 Specialty lab testing for deeper insights 20:05 Advice to parents and caregivers 25:00 Theo’s Voice and Theo’s Bridge Foundation 29:15 Why aren’t there more autism specialists? 31:35 Balancing hope with expectation: Video chronicles 34:05 Caring for the caretakers 37:00 What gives you hope for the future of autism? 39:45 Social media resources Additional Resources: TikTok - theosvoice2 TikTok - Theo's Bridge Donate to Help an Autism Family get answers they deserve Spectrum Awakening Subscribe, Rate, & Review The Lab Report Thanks for tuning in to this week’s episode of The Lab Report, presented by Genova Diagnostics, with your hosts Michael Chapman and Patti Devers. If you enjoyed this episode, please hit the subscribe button and give us a rating or leave a review. Don’t forget to visit our website, like us on Facebook, follow us on X, Instagram, and LinkedIn. Email Patti and Michael with your most interesting and pressing questions on functional medicine: [email protected]. And, be sure to share your favorite Lab Report episodes with your friends and colleagues on social media to help others learn more about Genova and all things related to functional medicine and specialty lab testing. To find a qualified healthcare provider to connect you with Genova testing, or to access select products directly yourself, visit Genova Connect. Disclaimer: The content and information shared in The Lab Report is for educational purposes only and should not be taken as medical advice. The views and opinions expressed in The Lab Report represent the opinions and views of Michael Chapman and Patti Devers and their guests. See omnystudio.com/listener for privacy information.

Anurag Singh MD, PhD. is a physician, researcher, immunologist, and one of the leading voices behind the science of Urolithin A – a gut microbiome metabolite. Urolithin A is crucial for mitochondrial health by stimulating mitophagy. Dr. Singh breaks down the science and explains his extensive research into how this postbiotic compound could play a major role in cellular energy and longevity. Whether you’re an athlete, a health optimizer, or just curious about the future of longevity science, this conversation with Dr. Anurag Singh is packed with cutting-edge, evidence-based insights you won’t want to miss. Today on The Lab Report: 3:05 Meet Dr. Anurag Singh and learn about Urolithin A 6:45 Substrates, prevalence, and specific gut commensal bacteria 9:40 Mitophagy and mitochondrial health 12:55 Immunology and aging 15:35 Urolithin A and muscle mass 17:45 Academic research a-ha moments 20:15 Clinical benefits of Urolithin A 23:00 Food based approach vs. supplementation 25:25 Safety and contraindications 27:00 Ranking your supplement stack 29:10 The Fireball Additional Resources: Timeline Mitopure Subscribe, Rate, & Review The Lab Report Thanks for tuning in to this week’s episode of The Lab Report, presented by Genova Diagnostics, with your hosts Michael Chapman and Patti Devers. If you enjoyed this episode, please hit the subscribe button and give us a rating or leave a review. Don’t forget to visit our website, like us on Facebook, follow us on X, Instagram, and LinkedIn. Email Patti and Michael with your most interesting and pressing questions on functional medicine: [email protected]. And, be sure to share your favorite Lab Report episodes with your friends and colleagues on social media to help others learn more about Genova and all things related to functional medicine and specialty lab testing. To find a qualified healthcare provider to connect you with Genova testing, or to access select products directly yourself, visit Genova Connect. Disclaimer: The content and information shared in The Lab Report is for educational purposes only and should not be taken as medical advice. The views and opinions expressed in The Lab Report represent the opinions and views of Michael Chapman and Patti Devers and their guests. See omnystudio.com/listener for privacy information.

What if the secret to a longer, healthier life isn’t found in the latest biohacking trend but in the small, sustainable choices you make every day? In this episode, we meet Dr. Jennifer Timmons, a longevity expert and the founder of Timmons Wellness, a concierge medical practice built around personalized, proactive care. Dr. Timmons has made it her mission to help patients move beyond conventional care to focus on optimizing how they age. Today we cut through the biohacker noise to remind you how your hobbies and daily habits impact how you age. Whether you’re just starting your wellness journey or already deep in the optimization rabbit hole, Dr. Jennifer Timmons offers actionable steps to help you live better, longer. Back to the basics! Today on The Lab Report: 3:45 Meet Dr. Jennifer Timmons - her thoughts on biohacker quick fixes 7:55 Hobbies as a health strategy 11:05 Daily choices that impact aging 16:30 Exercise snacks and movement 20:10 Extreme routines: where to draw the line 23:00 Educating yourself and finding trusted sources 28:00 Working with Dr. Timmons 28:45 The Fireball Additional Resources: Timmons Wellness @jennifertimmonsmd Subscribe, Rate, & Review The Lab Report Thanks for tuning in to this week’s episode of The Lab Report, presented by Genova Diagnostics, with your hosts Michael Chapman and Patti Devers. If you enjoyed this episode, please hit the subscribe button and give us a rating or leave a review. Don’t forget to visit our website, like us on Facebook, follow us on Twitter, Instagram, and LinkedIn. Email Patti and Michael with your most interesting and pressing questions on functional medicine: [email protected]. And, be sure to share your favorite Lab Report episodes with your friends and colleagues on social media to help others learn more about Genova and all things related to functional medicine and specialty lab testing. To find a qualified healthcare provider to connect you with Genova testing, or to access select products directly yourself, visit Genova Connect. Disclaimer: The content and information shared in The Lab Report is for educational purposes only and should not be taken as medical advice. The views and opinions expressed in The Lab Report represent the opinions and views of Michael Chapman and Patti Devers and their guests. See omnystudio.com/listener for privacy information.

Dr. Nasha Winters is a naturopathic physician with a deeply powerful story. Diagnosed with stage IV cancer at age 19 and given just a few months to live, she embarked on a relentless journey to self-education and integrative healing that ultimately saved her life. Now a leading expert in metabolic oncology, Dr. Nasha is passionate in her mission to transform healthcare by addressing underlying metabolic dysfunction that fuels not only cancer, but virtually all chronic diseases. Dr. Nasha Winters has a message of empowerment for cancer patients: by understanding and correcting the terrain of the body rather than merely attacking the tumor, we can shift from a disease-centered model to one rooted in true healing and prevention for everyone. This message will resonate not only in cancer, but also for anyone wanting to treat or prevent chronic disease. Today on The Lab Report: 3:45 Meet Dr. Nasha Winters and hear what a metabolic approach to cancer looks like 7:10 Nasha’s inspiring story 15:55 Fasting, ketosis, various diets in cancer 18:55 Ketosis and ketone bodies 24:10 Working with traditional oncology 29:10 Cachexia, sarcopenia, and fasting 34:00 Specialty testing in cancer patients 36:30 Facing mortality, past trauma, and taking control 41:10 Practical steps on where to start – diagnosis/prevention 45:30 Tend the terrain, connecting farming and medicine 48:30 Nasha’s current state 51:00 The Fireball Additional Resources: drnasha.com Tend the Terrain Substack The Metabolic Approach to Cancer Mistletoe and the Emerging Future of Integrative Oncology Subscribe, Rate, & Review The Lab Report Thanks for tuning in to this week’s episode of The Lab Report, presented by Genova Diagnostics, with your hosts Michael Chapman and Patti Devers. If you enjoyed this episode, please hit the subscribe button and give us a rating or leave a review. Don’t forget to visit our website, like us on Facebook, follow us on Twitter, Instagram, and LinkedIn. Email Patti and Michael with your most interesting and pressing questions on functional medicine: [email protected]. And, be sure to share your favorite Lab Report episodes with your friends and colleagues on social media to help others learn more about Genova and all things related to functional medicine and specialty lab testing. To find a qualified healthcare provider to connect you with Genova testing, or to access select products directly yourself, visit Genova Connect. Disclaimer: The content and information shared in The Lab Report is for educational purposes only and should not be taken as medical advice. The views and opinions expressed in The Lab Report represent the opinions and views of Michael Chapman and Patti Devers and their guests. See omnystudio.com/listener for privacy information.

Maggie Awad, NP is the founder of Elevate Performance Medicine and a leading functional sports medicine nurse practitioner. Drawing on her work with elite professional athletes, Maggie breaks down how an optimized microbiome and personalized nutrition can fuel energy production, decrease inflammation, and support recovery. This holistic approach allows athletes to train harder, bounce back faster, and sustain peak performance without burnout or injury. Whether you're a competitive athlete, weekend warrior, or high-performer chasing longevity in your sport or career, Maggie Awad shifts the paradigm from symptom management to true root-cause optimization. Today on The Lab Report: 5:15 Meet Maggie Awad and learn what “Functional Sport Medicine” means 8:10 Why did Maggie choose this specialty 10:45 Common health issues among all athletes 12:30 Gut health and stool testing 17:20 Overtraining and the importance of sleep and recovery 18:50 Nutritional deficiencies in athletes – glycine tangent 20:50 Hormone optimization and supplementation 23:00 Maggie’s patient population and practice 25 :40 The Fireball   Additional Resources: Elevate Performance Medicine Subscribe, Rate, & Review The Lab Report Thanks for tuning in to this week’s episode of The Lab Report, presented by Genova Diagnostics, with your hosts Michael Chapman and Patti Devers. If you enjoyed this episode, please hit the subscribe button and give us a rating or leave a review. Don’t forget to visit our website, like us on Facebook, follow us on Twitter, Instagram, and LinkedIn. Email Patti and Michael with your most interesting and pressing questions on functional medicine: [email protected]. And, be sure to share your favorite Lab Report episodes with your friends and colleagues on social media to help others learn more about Genova and all things related to functional medicine and specialty lab testing. To find a qualified healthcare provider to connect you with Genova testing, or to access select products directly yourself, visit Genova Connect. See omnystudio.com/listener for privacy information.

Celebrate the magic of the season with our special Christmas episode as we unwrap the 5 Love Languages and explore why love truly is the greatest gift of all. Whether it’s words that warm the heart, thoughtful acts of kindness, actual Christmas gifts, quality time with family and friends, or a comforting touch, we’ll help you discover how to give – and receive- love in ways that matter most. Cozy up, tune in, and get ready to spread a little more love this season. Subscribe, Rate, & Review The Lab Report Thanks for tuning in to this week’s episode of The Lab Report, presented by Genova Diagnostics, with your hosts Michael Chapman and Patti Devers. If you enjoyed this episode, please hit the subscribe button and give us a rating or leave a review. Don’t forget to visit our website, like us on Facebook, follow us on Twitter, Instagram, and LinkedIn. Email Patti and Michael with your most interesting and pressing questions on functional medicine: [email protected]. And, be sure to share your favorite Lab Report episodes with your friends and colleagues on social media to help others learn more about Genova and all things related to functional medicine and specialty lab testing. To find a qualified healthcare provider to connect you with Genova testing, or to access select products directly yourself, visit Genova Connect. Disclaimer: The content and information shared in The Lab Report is for educational purposes only and should not be taken as medical advice. The views and opinions expressed in The Lab Report represent the opinions and views of Michael Chapman and Patti Devers and their guests. See omnystudio.com/listener for privacy information.

The gut microbiome is more than just bacteria. It encompasses all organisms and genetic material including yeast, viruses, and archaea. It is a common belief that yeast in the GI tract needs to be eradicated. But not so fast. In this episode, we focus on the mycobiome. We examine the dual roles of commensal and pathogenic yeast species within the GI tract, exploring how they influence immune signaling, metabolic function, and mucosal integrity. We also discuss emerging evidence linking fungal dysbiosis to conditions such as Inflammatory Bowel Disease, cancer, and systemic inflammation. If you’re interested in the clinical science behind how yeast can support health – or contribute to disease - this episode explores a topic often overlooked in longevity medicine. Today on The Lab Report: 4:00 The Gut Mycobiome – needs a new name 6:40 Yeast vs. Bacteria 9:00 Development of the commensal mycobiome 11:00 The important role of yeast & their metabolites 15:25 Candida and Malassezia 18:45 Saccharomyces 21:05 Dietary influences and fermented foods 23:30 Question of the Day If yeast grows out in culture on the GI Effects, what next? Additional Resources: GI Effects Stool Profile Microbiomix  Subscribe, Rate, & Review The Lab Report Thanks for tuning in to this week’s episode of The Lab Report, presented by Genova Diagnostics, with your hosts Michael Chapman and Patti Devers. If you enjoyed this episode, please hit the subscribe button and give us a rating or leave a review. Don’t forget to visit our website, like us on Facebook, follow us on Twitter, Instagram, and LinkedIn. Email Patti and Michael with your most interesting and pressing questions on functional medicine: [email protected]. And, be sure to share your favorite Lab Report episodes with your friends and colleagues on social media to help others learn more about Genova and all things related to functional medicine and specialty lab testing. To find a qualified healthcare provider to connect you with Genova testing, or to access select products directly yourself, visit Genova Connect. Disclaimer: The content and information shared in The Lab Report is for educational purposes only and should not be taken as medical advice. The views and opinions expressed in The Lab Report represent the opinions and views of Michael Chapman and Patti Devers and their guests. See omnystudio.com/listener for privacy information.

The Thanksgiving holiday is more than just family, friends, food, and football. It is an opportunity to be reminded of the importance of gratitude. Although being thankful seems like just a nice moral platitude, gratitude interventions are shown to have surprisingly important clinical implications for our health.   On today’s episode, we talk Thanksgiving ‘fun facts,’ gratitude interventions, and strategies to combat holiday season stress and weight gain.   Today on The Lab Report:  3:10 Fun facts about Thanksgiving  7:35 Gratitude interventions and health  11:15 Strategies to prevent holiday weight gain  14:30 Keto, Vegan, Carnivore, Omnivore holiday dinner menus  16:45 Kitchen Cook-cophany!  Subscribe, Rate, & Review The Lab Report  Thanks for tuning in to this week’s episode of The Lab Report, presented by Genova Diagnostics, with your hosts Michael Chapman and Patti Devers. If you enjoyed this episode, please hit the subscribe button and give us a rating or leave a review.  Don’t forget to visit our website, like us on Facebook, follow us on Twitter, Instagram, and LinkedIn. Email Patti and Michael with your most interesting and pressing questions on functional medicine: [email protected].   And, be sure to share your favorite Lab Report episodes with your friends and colleagues on social media to help others learn more about Genova and all things related to functional medicine and specialty lab testing.   To find a qualified healthcare provider to connect you with Genova testing, or to access select products directly yourself, visit Genova Connect.   Disclaimer: The content and information shared in The Lab Report is for educational purposes only and should not be taken as medical advice. The views and opinions expressed in The Lab Report represent the opinions and views of Michael Chapman and Patti Devers and their guests.   See omnystudio.com/listener for privacy information.

Gut motility may be the most important and least discussed aspect of health. One vital part of gut motility is the Migrating Motor Complex. The Migrating Motor Complex (MMC) is the gut’s “street sweeper,” clearing food and bacteria to maintain intestinal homeostasis between meals. In this episode, we review its physiology, regulatory mechanisms, and clinical relevance – from SIBO to functional GI disorders – highlighting why this cyclical motility pattern matters for patient care. Today you’ll meet the migrating motor complex: your gut’s built-in street sweeper that clocks in when you’re not eating. This behind-the-scenes cleaning cycle is essential to GI health! Today on The Lab Report: 3:20 Gut motility – peristalsis and segmentation 5:45 Migrating Motor Complex (MMC) 8:40 Motilin, serotonin, and the vagus nerve 11:15 Acidification of the small intestine and Motilin 13:25 Signaling the vagus nerve 16:20 MMC’s role in SIBO/IMO 17:50 Prokinetics and meal spacing 22:00 Question of the Day What is the relationship between PPI’s and MMC? Additional Resources: SIBO Breath Test GI Effects Stool Profile Subscribe, Rate, & Review The Lab Report Thanks for tuning in to this week’s episode of The Lab Report, presented by Genova Diagnostics, with your hosts Michael Chapman and Patti Devers. If you enjoyed this episode, please hit the subscribe button and give us a rating or leave a review. Don’t forget to visit our website, like us on Facebook, follow us on Twitter, Instagram, and LinkedIn. Email Patti and Michael with your most interesting and pressing questions on functional medicine: [email protected]. And, be sure to share your favorite Lab Report episodes with your friends and colleagues on social media to help others learn more about Genova and all things related to functional medicine and specialty lab testing. To find a qualified healthcare provider to connect you with Genova testing, or to access select products directly yourself, visit Genova Connect. Disclaimer: The content and information shared in The Lab Report is for educational purposes only and should not be taken as medical advice. The views and opinions expressed in The Lab Report represent the opinions and views of Michael Chapman and Patti Devers and their guests. See omnystudio.com/listener for privacy information.

The microbiome continues to be viewed as a cornerstone of health, whether we are discussing the gastrointestinal tract, cardiovascular risk, immune dysfunction, and even cognitive health. One major contributions of the microbiome to our global health is in the production of short-chain fatty acids. Primary among these products is a compound known as n-butyrate. N-butyrate has profound roles, not only in our gut, but throughout our entire body. What are all the impacts of n-butyrate, and how do we foster an adequate supply of it? These are but some of the questions we discuss on today’s Lab Report. In this episode, we continue our spree on the importance of gut health. We cover food sources that are important for microbiome health, particularly for fermentation of short-chain fatty acids. We also cover how butyrate impacts the gut, the immune system, and much more. With all the profound roles of n-butyrate, it begs the question: is it the greatest of all the things made by our microbiome? Today on The Lab Report: 5:30 Gut microbiome production of SCFA’s (short-chain fatty acids) 6:30 Food sources of n-butyrate 8:00 Let’s Google It: The entomology of ‘butyrate’ 9:00 Butyrogenic species: What bacteria produce butyrate? 10:45 How butyrate is used throughout the body 13:00 Logical Speculation: n-butyrate, autoimmunity, and fiber 15:45 The gut-brain axis and appetite are influenced by butyrate 20:30 Skeletal muscle also responds to butyrate 23:30 Foods to eat to promote butyrate 26:00 N-Butyrate supplementation: mixed studies?   Additional Resources: GI Effects Stool Profile Microbiomix Subscribe, Rate, & Review The Lab Report Thanks for tuning in to this week’s episode of The Lab Report, presented by Genova Diagnostics, with your hosts Michael Chapman and Patti Devers. If you enjoyed this episode, please hit the subscribe button and give us a rating or leave a review. Don’t forget to visit our website, like us on Facebook, follow us on Twitter, Instagram, and LinkedIn. Email Patti and Michael with your most interesting and pressing questions on functional medicine: [email protected]. And, be sure to share your favorite Lab Report episodes with your friends and colleagues on social media to help others learn more about Genova and all things related to functional medicine and specialty lab testing. To find a qualified healthcare provider to connect you with Genova testing, or to access select products directly yourself, visit Genova Connect. Disclaimer: The content and information shared in The Lab Report is for educational purposes only and should not be taken as medical advice. The views and opinions expressed in The Lab Report represent the opinions and views of Michael Chapman and Patti Devers and their guests. See omnystudio.com/listener for privacy information.

Based on recent research, the term ‘dysbiosis’ is no longer a simple black-and-white diagnosis of a gut imbalance. The scientific understanding of a healthy microbiome is evolving. It’s no longer just about the laundry list of organisms present, but rather about their functionality for health and disease. In today’s episode, we unpack the term ‘dysbiosis.’ Join us to rethink what it means to have a healthy microbiome, the utility of novel algorithmic scoring, and how a deeper understanding of this complex ecosystem is opening doors to more targeted diagnostics and therapeutics.   Today on The Lab Report: 4:30 Healthy microbiome vs. Dysbiosis 8:00 Defining terms 10:10 Dysbiosis scoring algorithms 15:40 Functional approach to dysbiosis 16:30 Rethinking pathogens 19:25 The microbiome is reactionary – root cause is important! 23:15 Should we even be using the word “dysbiosis”? 24:25 Whole genome sequencing and gut functionality 28:00 Adaptability of the microbiome Additional Resources: GI Effects Stool Profile Microbiomix Subscribe, Rate, & Review The Lab Report Thanks for tuning in to this week’s episode of The Lab Report, presented by Genova Diagnostics, with your hosts Michael Chapman and Patti Devers. If you enjoyed this episode, please hit the subscribe button and give us a rating or leave a review. Don’t forget to visit our website, like us on Facebook, follow us on Twitter, Instagram, and LinkedIn. Email Patti and Michael with your most interesting and pressing questions on functional medicine: [email protected]. And, be sure to share your favorite Lab Report episodes with your friends and colleagues on social media to help others learn more about Genova and all things related to functional medicine and specialty lab testing. To find a qualified healthcare provider to connect you with Genova testing, or to access select products directly yourself, visit Genova Connect. Disclaimer: The content and information shared in The Lab Report is for educational purposes only and should not be taken as medical advice. The views and opinions expressed in The Lab Report represent the opinions and views of Michael Chapman and Patti Devers and their guests. See omnystudio.com/listener for privacy information.