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Big Picture Medicine

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Rating
★★★★★
5
from
3 reviews
This podcast has
161 episodes
Language
English
Explicit
No
Date created
2020/02/25
Latest episode
2026/05/27
Average duration
37 min.
Release period
57 days

Description

The health entrepreneurship podcast — focusing on big picture stuff. Interviews with health/biotech entrepreneurs and leaders having impact at scale. Health stuff a techbro/sis would find interesting. Think health meets the Tim Ferriss Show. Get in touch: [email protected]

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#141 $1.1B exit... then a MedTech with 12mo of runway called — Joe DeVivo (Butterfly Network)
2026/05/27
Part 2 with Joe DeVivo, the MedTech CEO who sold InTouch to Teladoc for over $1B and promised himself never to do another turnaround. Two years later, the board of Butterfly Network called w/12mo cash left. Here's how he did it.
#140 Should the NHS Trigger the £330M Palantir Break Clause? An Insider's Take
2026/05/11
Tom Bartlett spent 22 years inside the NHS. For three and a half years, he led the 150-person engineering team at NHS England that built the £330M Federated Data Platform with Palantir. He left a month ago and he's the only insider speaking publicly about what the platform actually does, what it costs, and whether the NHS has any credible alternative. We cover the architecture, the cost, the CLOUD Act, the BMJ exposé, the conflicts of interest at Chelsea & Westminster, and whether ministers should trigger the break clause.
🔥News: The New Healthcare AI Broker, Palantir Under Fire and Big Tech's Drug Discovery Mirage
2026/05/09
Jared Dashevsky, MD (Healthcare Huddle) and Ala Alenazi, PhD (Kinnevik) join Mustafa to discuss: The rise of the AI Broker (a middleman that's about to emerge)Palantir's £330M NHS break clauseOpenAI as pharma. We also discuss why drug discovery needs a "Human Genome Project 2.0"
🔥 News: Sequoia's Services Thesis, Kalshi for Clinical Trials and the PCP Apocalypse
2026/04/23
Jared Dashevsky, MD (Healthcare Huddle) and Ala Alenazi, PhD (Kinnevik) join Mustafa to discuss: Healthcare spends 75% on services and 3–4% on IT -- yet every AI startup is pitching a copilot. Sequoia's new thesis: the next trillion-dollar healthcare company won't sell software at all. It'll just do the work.The PCP Apocalypse. Urgent care has tripled, PCP density is down 22%, and behavioral health visits just overtook primary care. We debate whether the answer is more PCPs or changing the role.Kalshi for clinical trials. A Stanford PhD built a public market where nine frontier AI models bet on Phase 3 outcomes. Ala calls it "capitalism's final boss" and explains why it might be the most dangerous innovation in pharma this year.
🔥 News: Peptides, OpenEvidence and World Models in Healthcare with Ala Alenazi, PhD and Jared Dashevsky, MD
2026/04/05
Jared Dashevsky, MD (Healthcare Huddle) and Ala Alenazi, PhD (Kinnevik) join Mustafa to discuss: The wellness industry is now four times bigger than pharma -- and peptide parties are the new IV drip bars.What's going on there? OpenEvidence built a $12B company on physician search, but everyone's copying the playbook. Is there any moat?World models coming -- and why LLMs might not be enough to fix healthcare.
#139 Oura's $11B Bet, What a Gaming Exec Learned Building in Healthcare (Jason Oberfest — VP Healthcare at Oura)
2026/03/30
What can healthcare learn from Candy Crush? A lot. Jason Oberfest (VP Healthcare, Oura) used gaming psychology to build a first-of-its-kind digital health company (backed by Kleiner Perkins) — as well as roles at MySpace, Apple and more. Now he's bringing that playbook to Oura, following their $11B valuation and booming growth. Links Jason Oberfest: https://www.linkedin.com/in/jasonoberfest/ Dr Mustafa Sultan: https://www.musty.io/
#138 Six Lessons On Building a $100M Healthtech Company (Steve Kraus — Bessemer Venture Partners)
2026/02/11
What does it take to build a $100M healthcare company? Honestly, no one really knows — and the people who do don't tend to talk about it. But Steve Kraus and his team at Bessemer have actually studied it. They've analyzed hundreds of venture-backed healthtech companies and published the research. In this episode, I pull six lessons from their work and ask Steve to explain them. Links Steve Kraus: https://www.bvp.com/team/steve-kraus Dr Mustafa Sultan: ⁠⁠⁠⁠https://www.musty.io⁠ Music: “Habanera” by Kevin MacLeod Licensed under Creative Commons Attribution 4.0 https://creativecommons.org/licenses/by/4.0/ Edited for length.
#137 $1.1B MedTech Turnaround CEO – Joe DeVivo (Butterfly Network)
2025/12/17
What actually happens after you sell a company for $1.1B and never need to work again? Joe DeVivo is a legendary MedTech CEO who sold InTouch to Teladoc in a $1.1B deal and is now President, CEO, and Chairman of Butterfly Network. Joe has a very specific reputation in the industry. He steps in when companies get stuck. Often at the moment when a founder-led business needs a different kind of leadership to scale. In this episode, Joe breaks down his turnaround playbook step by step, from how he diagnoses what’s broken, to who stays, who goes, and how focus gets restored. He also opens up about something that’s rarely talked about. What it really feels like after a massive exit. When the money hits, the anxiety leaves your body, and you realize you never have to work again. What does “post-economic” life actually look like, and why do some people still choose to come back? We also trace Joe’s path from growing up in a family-run manufacturing business to becoming the CEO boards call in moments of crisis, and why invention and scaling are fundamentally different jobs. Links Butterfly Network: https://www.butterflynetwork.com Dr Mustafa Sultan: ⁠⁠⁠https://www.musty.io⁠
#136 Nabla, AI Ambient Scribe ($120M Raised) — CEO, Alex LeBrun
2025/10/13
In 2023, Alexandre Lebrun pointed two exits in conversational AI at Medicine. Nabla raised $120M and spread to 130+ orgs and 85,000 clinicians in record time.  But in the ambient AI game -- it seems like distribution beats all. How will Nabla win? Links Nabla: https://www.nabla.com/ Dr Mustafa Sultan: ⁠⁠⁠https://www.musty.io⁠
#135 $1.4bn Startup Tackling Loneliness, Papa (CEO, Andrew Parker)
2025/08/25
In 2017, Andrew Parker launched Papa with a 1-800 number, offering 'grandkids-on-demand' in Miami. By 2021, the company was valued at $1.4bn (backed by SoftBank and Tiger Global). This is a YC-backed gig economy company operating in the regulated elder care market at unicorn scale. On paper it shouldn't have worked -- and yet it did. Links Papa: https://www.papa.com/ Dr Mustafa Sultan: ⁠⁠⁠https://www.musty.io⁠
#134 Sean Duffy, Omada Health ($1bn+ Valuation)
2025/01/01
According to Business Insider, Omada Health has quietly filed its S-1 to prepare for an IPO. Here's how Sean Duffy (CEO & Co-founder) built it. 0:00 Intro 0:17 Signing first customer 1:51 How to have good ideas in healthcare 4:00 Why metabolic health is a hard area to innovate in 5:18 What the MVP product looked like 11:16 Sean's secret tactics 14:55 Operational innovation as a differentiator 20:19 The Omada playbook — is it repeatable? 25:31 What boss moves have you made Sean? 29:37 The difference between good and great 32:29 Sean's best tip on selling in enterprise healthcare 33:35 Sean's advice to himself Links Omada Health: https://www.omadahealth.com Dr Mustafa Sultan: ⁠⁠https://www.musty.io⁠
#133 A New Radiology Foundation Model ($160M Raised) — Harrison.ai CEO, Dr Aengus Tran
2024/10/27
Dr Aengus Tran is the CEO of Harrison.ai — an Australian radiology AI startup who have raised $160M. Harrison.ai just released their radiology foundation model, Harrison.rad.1. And it's really good. 0:00 Intro 2:25 I'm glad I didn't found my startup in the US 4:21 Partnering with a clinical operator is key 7:28 Scrappy stories from the early days 11:17 Where human radiologists outperform AI (zero-shot learning) 17:23 Big bets on the future of radiology 21:18 What happens when GPT-8 arrives? 25:29 How can AI reach suprahuman radiology performance? 28:58 What boss moves did you make? Links Harrison.ai: ⁠https://harrison.ai⁠ Dr Mustafa Sultan: ⁠https://www.musty.io⁠
#132 Arcadia CEO ($100M ARR) on How To Sell Enterprise Healthcare — Michael Meucci
2024/08/26
Michael Meucci (CEO) transformed Arcadia — formerly a mid-sized consultancy into a healthcare platform with $100M of Annual Recurring Revenue. How? Lots of smart moves, including becoming really good at enterprise healthcare selling. Here's how he did it. Links Arcadia: https://arcadia.io/ Dr Mustafa Sultan: https://www.musty.io/
#131 Scaling Contraceptive App to 2M Users By Daring Not to Be Free (Dr Elina Berglund, CEO Natural Cycles)
2024/05/27
Dr Elina Berglund is the CEO/Co-founder of Natural Cycles, which she has grown to 2M users. When every other app seemed to be free — she made a brave decision: She charged her users a monthly fee. And it worked... 0:57 - The Birth of Natural Cycles 2:57 - The Decision to Charge from the Start 3:47 - Building Trust Through Pricing 4:23 - From Personal Struggles to Public Solution 5:52 - Creating the Fail-Safe Algorithm 6:32 - Collaboration with CERN Colleagues 7:13 - The Human Body: Complex Beyond Measure 8:37 - The Promise and Challenge of Wearables 10:16 - Understanding User Behavior 11:04 - Gaining Regulatory Approval 12:26 - Secrets to Growth and Marketing 13:43 - The Challenge of Direct-to-Consumer Healthcare 16:02 - Data-Driven Decision Making 17:13 - Instincts Versus Data 19:01 - Staying Honest with Data 21:20 - Calibrating Communication for Investors 22:30 - Benefits of Being Profitable 24:08 - Data as a Superpower 24:59 - Overcoming Negative PR 27:13 - Future of Contraception 29:30 - Impact of Roe v. Wade Overturning Links Natural Cycles: https://www.naturalcycles.com/ Dr Mustafa Sultan: https://www.musty.io/
#130 Kaia Health, Raising $125M By Turning $50,000 Elite Pain Rehab into an App (CEO, Konstantin Mehl)
2024/03/24
Konstantin started Kaia Health after paying $50,000 to cure his back pain at an elite pain rehab centre. It worked. But it seemed stupid. Why did this need to cost $50,000? Kaia Health has since raised $125M and helped 625,000 users. 0:00 The 90 second story 1:22 How did he grow 20% every week? 2:15 Market timing is everything 7:43 We never put pressure on this making any money 10:51 How does an app cure back pain? 14:43 US vs Germany for digital health entrepreneurs 16:40 Go to market of Kaia Health 19:51 Why raise so much money? 24:57 The hero license Links Kaia Health: https://kaiahealth.com/ Dr Mustafa Sultan: https://www.musty.io/

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5 out of 5
3 reviews
★★★★★
Gerads 2020/10/18
terrific guests
awesome interviews with physicians thinking outside the box of traditional medicine. Very inspiring for this doc. Loved your episode with Dr Case and ...
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