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Dr. Dudley Lamming, Associate Professor of Medicine at the University of Wisconsin-Madison, reveals groundbreaking research on dietary protein, branched-chain amino acids (BCAAs), and healthy longevity. Learn how restricting dietary isoleucine extends median lifespan by 33%, why excess protein in sedentary lifestyles drives insulin resistance, and how resistance exercise alters your body's daily protein requirements. Should you really be eating more protein as you age? While fitness culture encourages high protein intake to prevent muscle loss, biogerontology research shows that excess dietary protein, particularly branched-chain amino acids like isoleucine, accelerates aging biology and insulin resistance in sedentary populations. In this interview, Dr. Dudley Lamming breaks down his landmark findings from over 350 studies and his lab's Cell Metabolism discovery showing that a 67% reduction in isoleucine extends male lifespan by 33% and dramatically slows the onset of physical frailty. Dr. Lamming explains how muscle tissue acts as a metabolic sink during resistance training, why mice on low-protein diets develop more efficient muscle fibers that match the strength of high-protein groups, and what the latest science says about protein requirements for individuals over age 50. 🌐 Connect with Dr. Dudley Lamming & The Lamming Lab: • Faculty Profile: https://www.med.wisc.edu • The Lamming Laboratory: https://lamminglab.medicine.wisc.edu 🔬 Scientific Citations & References Mentioned: 1. Knopf, B.A. & Lamming, D.W. (2026). The hallmarks of protein and amino acid restriction in aging and longevity. Cell Press Blue, 100079. DOI: 10.1016/j.cpblue.2026.100079 2. Green, C.L., Yeh, C.Y., ... Lamming, D.W. (2023). Dietary restriction of isoleucine increases healthspan and longevity of genetically heterogeneous mice. Cell Metabolism, 35(11): 1976-1995. PMID: 37939658 3. Cummings, N.E. et al., & Lamming, D.W. (2018). Decreased consumption of branched-chain amino acids improves metabolic health. Cell Reports, 24(3): 793-805. PMID: 29262313 4. Yu, D., Lamming, D.W. et al. (2021). Restoration of metabolic health by dietary isoleucine restriction requires hepatic FGF21. Cell Metabolism, 33(5): 891-904. PMID: 33951478 5. Lamming, D.W. et al. (2012). Rapamycin-induced insulin resistance is mediated by mTORC2 loss and accompanied by Akt/GSK3beta dysregulation. Science, 335(6076): 1638-1643. PMID: 22461497 ⚠️ Medical Disclaimer: Modern Healthspan content is for educational and informational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult a qualified physician or healthcare provider before making changes to your health regimen, diet, or lifestyle. Find us on Substack and YouTube.

Dr. Ana Maria Cuervo, Co-Director of the Institute for Aging Research at Albert Einstein College of Medicine, reveals how restoring chaperone-mediated autophagy (CMA) cleanses toxic proteins and preserves cognitive health. Discover why tau is the ideal cellular cleaning substrate until aging modifications clog the system, how restoring CMA clears pathology and protects memory, and how just 20 minutes of gentle exercise activates cellular recycling across tissues. What if our cells deteriorate with age simply because their precision recycling system fails? In this episode, Dr. Ana Maria Cuervo, pioneer of chaperone-mediated autophagy (CMA), details the molecular machinery that clears damaged proteins before they become toxic aggregates. She reveals how aging lysosomes lose the vital LAMP-2A receptor as membrane lipids stiffen, causing proteins like tau and alpha-synuclein to build up and fuel neurodegeneration. Dr. Cuervo shares breakthrough findings where small molecules upregulate LAMP-2A, clearing established protein aggregates and restoring memory in Alzheimer's models. She explains the "tau paradox"-why tau is CMA's preferred target, yet modifications like phosphorylation jam the translocation pore. Finally, she offers practical lifestyle protocols, showing how just 20 minutes of gentle exercise three times weekly and strategic meal spacing reactivate cellular cleaning across tissues. 🌐 Connect with Dr. Ana Maria Cuervo & Albert Einstein College of Medicine: • Faculty Profile: https://einsteinmed.edu/faculty/8784/ana-maria-cuervo/ • Institute for Aging Research: https://einsteinmed.edu/centers/aging/ 🔬 Scientific Citations & References Mentioned: 1. Bourdenx, M., et al., & Cuervo, A. M. (2021). Chaperone-mediated autophagy prevents collapse of the neuronal metastable proteome. Cell, 184(10), 2696-2714. 2. Dong, S., et al., & Cuervo, A. M. (2021). Chaperone-mediated autophagy sustains haematopoietic stem-cell function. Nature, 591(7849), 305-309. 3. Khawaja, R. R., et al., & Cuervo, A. M. (2024). Sex-specific and cell-type-specific changes in chaperone-mediated autophagy across tissues during aging. Nature Aging, 4, 1612-1628. 4. Juste, Y. R., et al., & Cuervo, A. M. (2021). Reciprocal regulation of chaperone-mediated autophagy and the circadian clock. Nature Cell Biology, 23(10), 1055-1070. 5. Qiao, L., et al., & Cuervo, A. M. (2022). Protective role of chaperone-mediated autophagy against atherosclerosis. PNAS. 6. Zhang, C., & Cuervo, A. M. (2008). Restoration of chaperone-mediated autophagy in aging liver improves cellular maintenance and organ function. Nature Medicine, 14(9), 959-965.

Dr. Julie Andersen, Professor at the Buck Institute for Research on Aging, reveals how restoring mitochondrial recycling (mitophagy) protects brain cells from neurodegenerative diseases like Parkinson's and Alzheimer's. Discover why damaged mitochondria leak DNA into the cytoplasm to trigger chronic sterile neuroinflammation, how engineered T-regulatory cells cross the blood-brain barrier to clear pathology, and why Urolithin A restores cellular healthspan through a "calm not kill" approach. Can we stop neurodegenerative diseases before symptoms ever appear? In this episode, Dr. Julie Andersen, leader of the Andersen Laboratory at the Buck Institute for Research on Aging, explains the molecular drivers of brain aging. Dr. Andersen explains how post-mitotic neurons rely entirely on mitophagy to eliminate damaged organelles. When mitochondrial clearance slows with age, damaged mitochondria leak mitochondrial DNA into the cytosol, activating the ancient cGAS-STING immune sensor and sparking chronic neuroinflammation. She shares the findings from her landmark studies showing how environmental stressors impact brain support cells, and why blanket destruction of senescent cells can be counterproductive. Dr. Andersen highlights hopeful translational solutions: from engineered autologous T-regulatory cells that cross the blood-brain barrier to target plaques and produce anti-inflammatories on demand, to a "calm not kill" senomorphic approach using Urolithin A to suppress toxic SASP secretions without harming vital brain cells. 🔬 Scientific Citations & References Mentioned: 1. Chinta, S. J., et al., & Andersen, J. K. (2018). Cellular Senescence Is Induced by the Environmental Neurotoxin Paraquat and Contributes to Neuropathology Linked to Parkinson's Disease. Cell Reports, 22(4), 930-940. 2. Andersen, J. K., et al. Development of Mitophagy-Inducing Small Molecules (MIC) as Therapeutics for Aging and Alzheimer's Disease. Geroscience / Nature Aging. 3. Ballesteros-Alvarez, J., Andersen, J. K., et al. Urolithin A Restores Mitophagy, Reduces Cytosolic mtDNA Leakage, Downregulates cGAS-STING, and Attenuates Paracrine Senescence in Aging CNS Models. 4. Sharma, A., & Andersen, J. K. Urolithin A acts as a senomorphic agent to suppress the senescence-associated secretory phenotype (SASP) without inducing cell death. 🌐 Connect with Dr. Julie Andersen & The Buck Institute: • Buck Institute Faculty Profile: https://www.buckinstitute.org/lab/andersen-lab/ • Buck Institute for Research on Aging: https://www.buckinstitute.org Qitone (10% off: HEALTH10) https://tidd.ly/4jGklry Qitone Esters Powder Seeking Health supplements: 10% discount code Richard10 https://crrnt.app/SEEK/-dm0MyrQ, Histamine Nutrients https://crrnt.app/SEEK/EpM7paAO AX3 Life Astaxanthin 20% discount code MODERN20 https://ax3.life/MODERN20 https://www.choosemuse.com Stemregen 15% discount Code MODERN https://tinyurl.com/45z968yr (Only available in the US) Renue by Science all 10% discount with code MHS https://renuebyscience.com/ Nuchido Time+ 20% discount of first purchase with code MODERN20 https://nuchido.com/MODERN If you would like to support our channel please consider signing up on patreon https://patreon.com/ModernHealthspan You can also find us on YouTube at https://www.youtube.com/c/modernhealthspan

Dr. Martin Picard, head of the Mitochondrial Psychobiology Laboratory at Columbia University, explains how cellular energy constraints and emotional stress drive biological aging. Discover how psychological allostatic load burns up to 60% more cellular energy, why hair graying is naturally reversible upon recovery, and how providing periods of physiological rest allows your mitochondria to restore cellular healthspan. Can psychological stress and mindset directly change the biology of your mitochondria? In this episode, Dr. Martin Picard, Associate Professor of Behavioral Medicine at Columbia University Irving Medical Center, breaks down his pioneering field of mitochondrial psychobiology. Dr. Picard reveals how acute and chronic mental stressors signal directly to glucocorticoid receptors inside mitochondria, driving damaged cells into a costly state of hypermetabolism where they burn 60% more energy simply to stay alive. This metabolic burden steals vital energy away from core anti-aging maintenance, including DNA repair, telomere integrity, and cellular cleanup. He shares the science behind his landmark study demonstrating that human hair graying is naturally reversible when psychological stress is relieved, proving that biological aging is not a rigid linear decline but a malleable process with substantial wiggle room. Dr. Picard also explores why damaged mitochondria undergo herniation and leak cell-free mitochondrial DNA (cf-mtDNA) into the cytoplasm and bloodstream, triggering innate immune alarms and sterile inflammation. Finally, we discuss actionable strategies to measure and protect your bioenergetic health, from VO2 max and cellular stress biomarkers like GDF-15 to the restorative power of meditation and physiological rest. 🔬 Scientific Citations & References Mentioned: 1. Rosenberg, A. M., et al. (2021). Quantitative mapping of human hair graying and reversal in relation to life stress. eLife, 10, e67437. 2. Picard, M., & McEwen, B. S. (2018). Psychological Stress and Mitochondria: A Systematic Review. Psychosomatic Medicine, 80(2), 141-153. 3. Picard, M., Juster, R. P., & McEwen, B. S. (2014). Mitochondrial allostatic load puts the 'gluc' back in glucocorticoids. Nature Reviews Endocrinology, 10(5), 303-310. 4. Sturm, G., et al., & Picard, M. (2023). Overactive cell metabolism linked to biological aging / Hypermetabolism in human cellular aging. Communications Biology. 🌐 Connect with Dr. Martin Picard: • Website: https://martinpicard.energy • Substack (The Science and Experience of Energy): https://martinpicard.substack.com • Substack profile - substack.com/@martinpicard • LinkedIn - linkedin.com/in/mitopsychobio • X - x.com/MitoPsychoBio • Instagram - instagram.com/martinpicard.energy/ Qitone (10% off: HEALTH10) https://tidd.ly/4jGklry Qitone Esters Powder Seeking Health supplements: 10% discount code Richard10 https://crrnt.app/SEEK/-dm0MyrQ, Histamine Nutrients https://crrnt.app/SEEK/EpM7paAO AX3 Life Astaxanthin 20% discount code MODERN20 https://ax3.life/MODERN20 https://www.choosemuse.com Stemregen 15% discount Code MODERN https://tinyurl.com/45z968yr (Only available in the US) Renue by Science all 10% discount with code MHS https://renuebyscience.com/ Nuchido Time+ 20% discount of first purchase with code MODERN20 https://nuchido.com/MODERN If you would like to support our channel please consider signing up on patreon https://patreon.com/ModernHealthspan You can also find us on YouTube at https://www.youtube.com/c/modernhealthspan

Join Dr. John Sedivy, Director of the Center on the Biology of Aging at Brown University, as he explains how ancient jumping genes (LINE-1 retrotransposons) awaken as our epigenome decays, driving chronic sterile inflammation and cellular aging. Discover how reverse transcriptase inhibitors and epigenetic maintenance can slow biological aging clocks and protect tissue healthspan. What if ancient viral elements embedded in our DNA wake up as we age to drive chronic systemic inflammation? In this episode, Dr. John Sedivy breaks down his groundbreaking discovery of LINE-1 retrotransposons ("jumping genes"). Dr. Sedivy explains how age-related heterochromatin decay allows dormant LINE-1 elements to replicate, generating cytoplasmic cDNA that triggers the cGAS-STING innate immune pathway and fuels the pro-inflammatory SASP in senescent cells. He discusses how repurposing generic reverse transcriptase inhibitors like Lamivudine can halt this cascade, lower systemic inflammatory markers, and profoundly decelerate Horvath DNA methylation aging clocks. Learn about ongoing clinical trials in Alzheimer's disease, government-backed ARPA-H longevity programs, and how preserving epigenetic integrity can combat inflammaging. 🔬 Scientific Citations & References Mentioned: 1. De Cecco, M., et al. (2019). L1 drives IFN in senescent cells and promotes age-associated inflammation. Nature, 566(7742), 73-78. 2. Kelsey, K., Sedivy, J. M., et al. (2025/2026). Retrotransposon Activation in the Aged and Alzheimer's Disease Brain Examined by Nanopore Long-read DNA Sequencing. 3. Simon, M., et al. (2019). LINE1 derepression in aged and senescent tissues promotes inflammation and can be targeted by reverse transcriptase inhibitors. Cell Metabolism / Nature Aging. 🌐 Links in this video: - Center on the Biology of Aging at Brown University: https://biologyofaging.brown.edu - bioRxiv Preprints: https://www.biorxiv.org Qitone (10% off: HEALTH10) https://tidd.ly/4jGklry Qitone Esters Powder Seeking Health supplements: 10% discount code Richard10 https://crrnt.app/SEEK/-dm0MyrQ, Histamine Nutrients https://crrnt.app/SEEK/EpM7paAO AX3 Life Astaxanthin 20% discount code MODERN20 https://ax3.life/MODERN20 https://www.choosemuse.com Stemregen 15% discount Code MODERN https://tinyurl.com/45z968yr (Only available in the US) Renue by Science all 10% discount with code MHS https://renuebyscience.com/ Nuchido Time+ 20% discount of first purchase with code MODERN20 https://nuchido.com/MODERN If you would like to support our channel please consider signing up on patreon https://patreon.com/ModernHealthspan You can also find us on YouTube at https://www.youtube.com/c/modernhealthspan

Join us as Dr. Irina Conboy, former UC Berkeley professor and Chief Science Officer at Generation Lab, reveals a groundbreaking metabolic senolytic discovery. Learn how combining Dichloroacetate (DCA), Metformin, and a 10-fold lower dose of Navitoclax selectively eliminates senescent and cancer cells, extending post-treatment lifespan by 41.7% in old mice without inducing frailty or platelet toxicity Cellular senescence and cancer share a critical metabolic vulnerability: damaged, short-circuiting mitochondria and an inflexible reliance on glycolysis for survival. While first-generation senolytics like Navitoclax (ABT-263) demonstrated high potency, severe clinical side effects like platelet destruction (thrombocytopenia) stalled their translation. In this episode, Dr. Irina Conboy breaks down her lab's landmark 2026 paper in Aging. By utilizing Dichloroacetate (DCA) to force pyruvate into damaged mitochondria and Metformin to inhibit Complex I ATP synthesis, the team created a metabolic vise that drains energy exclusively in cancer and senescent cells. With their defenses compromised, a 10-fold reduced dose of Navitoclax triggers selective apoptosis while completely sparing healthy human tissues and platelets. Dr. Conboy explains how intermittent administration in 18-month-old mice extended post-treatment lifespan by 41.7% (+102 days) and improved treadmill endurance with zero increase in frailty. She also shares Generation Lab's upcoming pharmacological injectable designed to replace invasive therapeutic plasma exchange (TPE). 🔬 Scientific Citations & References Mentioned: 1. Robinson, Z., Amiri, P., Mehdipour, M., Conboy, M. J., & Conboy, I. M. (2026). Selective targeting of cancer and senescence via shared metabolic shifts extends lifespan of old mice. Aging, PMID: 42474306. 2. Jeon, O. H., et al., Campisi, J., & Conboy, I. M. (2022). Systemic induction of cellular senescence by old blood. Nature Metabolism, 4(8), 998-1006. 3. Mehdipour, M., et al., & Conboy, I. M. (2020). Rejuvenation of three germ layers tissues by exchanging old blood plasma with saline-albumin. Aging, 12(10), 8790-8819. 🌐 Links in this video: - Generation Lab: https://generationlab.biotech Qitone (10% off: HEALTH10) https://tidd.ly/4jGklry Qitone Esters Powder Seeking Health supplements: 10% discount code Richard10 https://crrnt.app/SEEK/-dm0MyrQ, Histamine Nutrients https://crrnt.app/SEEK/EpM7paAO AX3 Life Astaxanthin 20% discount code MODERN20 https://ax3.life/MODERN20 https://www.choosemuse.com Stemregen 15% discount Code MODERN https://tinyurl.com/45z968yr (Only available in the US) Renue by Science all 10% discount with code MHS https://renuebyscience.com/ Nuchido Time+ 20% discount of first purchase with code MODERN20 https://nuchido.com/MODERN If you would like to support our channel please consider signing up on patreon https://patreon.com/ModernHealthspan You can also find us on YouTube at https://www.youtube.com/c/modernhealthspan

Join us as Dr. Connie Weaver, Distinguished Research Professor at San Diego State University and National Academy of Medicine member, reveals the hidden science of bone loss, calcium bioavailability, and the gut-bone axis. Discover why fractures kill more people than most realize, why modern plant-forward diets are inadvertently blocking mineral absorption, how soluble corn fiber halts postmenopausal bone loss, and the strict 500mg calcium dosing rule you need to know. Osteoporotic fractures outnumber new diagnoses of heart disease and cancer combined, with 20% of hip fracture patients dying within 12 months. Yet bone health remains one of the most overlooked pillars of healthspan. In this episode, we sit down with Dr. Connie Weaver, one of the world's foremost authorities on mineral metabolism and bone remodeling. Dr. Weaver explains why nutrition plays a permissive role alongside resistance exercise, how the estrogen crash during menopause accelerates osteoclast bone resorption, and why high-dose Vitamin D trials have failed to stop fractures in the general population. She breaks down her landmark 3-decade research modeling calcium bioavailability across global diets (now integrated into Cronometer), revealing how high-oxalate and high-phytate plant diets are driving widespread calcium deficits. Finally, Dr. Weaver shares her groundbreaking discovery on the gut-bone axis - demonstrating how prebiotic soluble corn fiber feeds fiber-fermenting bacteria to stop postmenopausal bone loss - and clarifies the truth about calcium supplements and arterial plaque. 🔬 Scientific Citations & References Mentioned 1. Weaver, C. M., et al. (2016). Soluble corn fiber increases bone calcium retention in postmenopausal women in a dose-dependent manner. The American Journal of Clinical Nutrition, 104(3), 837-843. 2. Weaver, C. M., et al. (2021). Modeling calcium bioavailability in US and global diets: Impact of phytate, oxalate, and plant-forward dietary shifts. The Journal of Nutrition, 151(10), 3120-3128. 3. Whisner, C. M., & Weaver, C. M. (2016). Soluble corn fiber enhances calcium absorption and alters the gut microbiome in adolescent males and females. British Journal of Nutrition, 116(11), 1849-1856. 4. Weaver, C. M., et al. (2016). Calcium plus vitamin D supplementation and risk of fractures: an updated meta-analysis from the National Osteoporosis Foundation. Osteoporosis International, 27(1), 367-376. 🌐Links in this video - Dr. Connie Weaver's SDSU Faculty Page: https://ens.sdsu.edu/people/faculty/weaver-connie - Dr. Connie Weaver on LinkedIn: https://www.linkedin.com/in/connie-weaver-4754a39/ - USDA FoodData Central: https://fdc.nal.usda.gov/ - Cronometer (featuring Dr. Weaver's Bioavailability Model): https://cronometer.com/ Qitone (10% off: HEALTH10) https://tidd.ly/4jGklry Qitone Esters Powder Seeking Health supplements: 10% discount code Richard10 https://crrnt.app/SEEK/-dm0MyrQ, Histamine Nutrients https://crrnt.app/SEEK/EpM7paAO AX3 Life Astaxanthin 20% discount code MODERN20 https://ax3.life/MODERN20 https://www.choosemuse.com Stemregen 15% discount Code MODERN https://tinyurl.com/45z968yr (Only available in the US) Renue by Science all 10% discount with code MHS https://renuebyscience.com/ Nuchido Time+ 20% discount of first purchase with code MODERN20 https://nuchido.com/MODERN If you would like to support our channel please consider signing up on patreon https://patreon.com/ModernHealthspan You can also find us on YouTube at https://www.youtube.com/c/modernhealthspan

Join us as Dr. Noah Davidsohn, Co-Founder and Chief Scientific Officer of Rejuvenate Bio, reveals how systemic multi-gene therapy and in vivo partial cellular reprogramming can reverse age-related chronic diseases and double remaining lifespan. Discover the breakthrough science of AAV vector delivery, FGF21 and sTGFβR2 synergy, and companion animal clinical translation. What if a single gene therapy injection could simultaneously treat heart failure, kidney disease, and diabetes? In this episode, we sit down with Dr. Noah Davidsohn, CSO and Co-Founder of Rejuvenate Bio, spun out of George Church’s lab at Harvard Medical School. Dr. Davidsohn breaks down their landmark 2024 study in Cellular Reprogramming, which demonstrated a 109% increase in the remaining lifespan of extremely aged (124-week-old) wild-type mice using systemic AAV9 delivery of Yamanaka factors (OSK). He explains the mechanics of intermittent doxycycline pulsing to avoid tumor risks, the power of multi-gene master regulators like FGF21 and sTGFβR2 in RJB-01, and how treating companion dogs with Mitral Valve Disease serves as the ultimate translational bridge to human clinical trials. 🌐Links in this video - Rejuvenate Bio Website: https://www.rejuvenatebio.com - WeFund for Rejuvenate Bio: https://wefunder.com/rejuvenatebio Qitone (10% off: HEALTH10) https://tidd.ly/4jGklry Qitone Esters Powder Seeking Health supplements: 10% discount code Richard10 https://crrnt.app/SEEK/-dm0MyrQ, Histamine Nutrients https://crrnt.app/SEEK/EpM7paAO AX3 Life Astaxanthin 20% discount code MODERN20 https://ax3.life/MODERN20 https://www.choosemuse.com Stemregen 15% discount Code MODERN https://tinyurl.com/45z968yr (Only available in the US) Renue by Science all 10% discount with code MHS https://renuebyscience.com/ Nuchido Time+ 20% discount of first purchase with code MODERN20 https://nuchido.com/MODERN If you would like to support our channel please consider signing up on patreon https://patreon.com/ModernHealthspan You can also find us on YouTube at https://www.youtube.com/c/modernhealthspan

In this episode, board-certified neurologist Dr. David Perlmutter, author of Brain Defenders, reveals how your brain’s immune cells, the microglia, hold the key to preventing cognitive decline and neurodegenerative disease. For decades, neurodegenerative research has fixated on amyloid plaques and tau tangles, treating the downstream smoke while ignoring the raging metabolic fire beneath. In this comprehensive masterclass, Dr. Perlmutter reveals why the real driver of brain aging lies within microglia, the brain's resident immune defenders. Under healthy conditions, microglia nurture synapses and clear debris. But when triggered by elevated blood glucose, gut dysbiosis, environmental air toxins, or lack of deep sleep, they flip into an aggressive, destructive phenotype that destroys brain connections. Dr. Perlmutter shares practical, evidence-based protocols to keep your microglia in their protective state: why a fasting glucose above 90 mg/dL poses hidden risks, how muscle-derived myokines cross the blood-brain barrier, the truth about adult hippocampal neurogenesis, and the exact supplement stack (including DHA, Akkermansia, Urolithin A, DHM, and rosmarinic acid) supported by peer-reviewed science. 🌐Links in this video Dr Perlmutter's book Brain Defenders: Harness the Power of Your Immune Cells to Protect Your Brain for Life on Amazon https://amzn.to/4y4U77Y Dr Perlmutter's home page https://drperlmutter.com/ Qitone (10% off: HEALTH10) https://tidd.ly/4jGklry Qitone Esters Powder Seeking Health supplements: 10% discount code Richard10 https://crrnt.app/SEEK/-dm0MyrQ, Histamine Nutrients https://crrnt.app/SEEK/EpM7paAO AX3 Life Astaxanthin 20% discount code MODERN20 https://tinyurl.com/2t3w26nw https://www.choosemuse.com Stemregen 15% discount Code MODERN https://tinyurl.com/45z968yr (Only available in the US) Renue by Science all 10% discount with code MHS https://renuebyscience.com/ Nuchido Time+ 20% discount of first purchase with code MODERN20 https://nuchido.com/MODERN If you would like to support our channel please consider signing up on patreon https://patreon.com/ModernHealthspan You can also find us on YouTube at https://www.youtube.com/c/modernhealthspan

Can AI simulate your exact biology to predict how long you will live? Today we sit down with Dr. Dmitri Chebanov, computational biologist from Memorial Sloan Kettering Cancer Center and Chief Scientist at Holivita, to explore how AI digital twins and multi-omics are turning reactive medicine into proactive longevity. For decades, health optimization has relied on trial and error: try a new supplement, change your diet, wait three months, and hope your blood work improves. But biology is complex, and standard medical care only reacts after disease develops. Dr. Dmitri Chebanov shares how cutting-edge transformer neural networks, trained on multi-omic patient data, can create a high-dimensional "Digital Twin" of your body. Originally developed to simulate clinical trials in oncology and reduce the 90% trial failure rate, this technology is now transitioning to personal longevity. We break down the three critical layers of a digital twin (whole genome sequencing, dynamic biomarkers like DNA methylation, and real-time symptoms), how to simulate lifestyle interventions before taking a single pill, and what the future of real-time predictive healthcare looks like

Silicon Valley tech entrepreneur Haresh Patel joins Modern Healthspan to reveal how applying systems engineering and artificial intelligence can solve healthcare's chronic diagnostic crisis. After a 55-year struggle across 12 failed medical diagnoses, Haresh founded Sanare Health AI to synthesize fragmented medical records, map longitudinal health timelines, and uncover root causes of chronic illness. Why does modern healthcare fail patients with complex chronic illness? In this deep-dive interview, Silicon Valley engineer and entrepreneur Haresh Patel explains how extreme medical specialization and transactional 13-minute doctor visits create data silos that mask the true root causes of disease. Drawing from his 55-year battle with unexplained chronic urticaria and his experience managing $1.5T in data platforms, Haresh details how his new venture, Sanare Health AI, unifies decades of scattered medical records with mind-body trauma timelines. Rather than replacing doctors, AI acts as a vital pressure-relief valve—synthesizing complex patient histories so clinicians can focus on meaningful dialogue and root-cause solutions rather than short-term symptom suppression. Discover why you must become the CEO of your own health, how 12-month timeline tracking uncovers hidden disease triggers, and the future of AI-driven personalized medicine. 🌐Links in this video https://sanarehealth.ai/ Qitone (10% off: HEALTH10) https://tidd.ly/4jGklry Qitone Esters Powder Seeking Health supplements: 10% discount code Richard10 https://crrnt.app/SEEK/-dm0MyrQ, Histamine Nutrients https://crrnt.app/SEEK/EpM7paAO AX3 Life Astaxanthin 20% discount code MODERN20 https://tinyurl.com/2t3w26nw https://www.choosemuse.com Stemregen 15% discount Code MODERN https://tinyurl.com/45z968yr (Only available in the US) Renue by Science all 10% discount with code MHS https://renuebyscience.com/ Nuchido Time+ 20% discount of first purchase with code MODERN20 https://nuchido.com/MODERN If you would like to support our channel please consider signing up on patreon https://patreon.com/ModernHealthspan You can also find us on YouTube at https://www.youtube.com/c/modernhealthspan

USC Gerontology Professor Dr. Changhan David Lee breaks down the discovery of MOTS-c, a novel mitochondrial-derived peptide that functions as an exercise mimetic, cellular stress responder, and immunomodulator. Are mitochondria more than just cellular powerhouses? In this episode of Modern Healthspan, Dr David Lee, Associate Professor at the USC Leonard Davis School of Gerontology and co-discoverer of MOTS-c, joins us for a deep dive into the emerging world of mitochondrial-derived peptides (MDPs). Dr. Lee explains how these small microproteins, encoded within the mitochondrial 12S rRNA locus, act as critical retrograde signaling molecules. We explore how MOTS-c translocates to the nucleus during metabolic stress, coordinates with AMPK and hypothalamic POMC neurons, and functions as an interferon-responsive host defense peptide. Additionally, Dr. Lee shares findings from preclinical models examining sarcopenia, muscle homeostasis, and age-related physical capacity, while providing an update on the current regulatory state, WADA anti-doping classification, and human translational pipeline of MDP research. 🌐Links in this video Dr David Lee's page at USC https://gero.usc.edu/faculty/lee/ 📚 References & Scientific Papers Mentioned: (2015). The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance. Cell Metabolism, 21(3), 443–454. https://pmc.ncbi.nlm.nih.gov/articles/PMC4350682/ (2021). MOTS-c is an exercise-induced mitochondrial-encoded regulator of age-dependent physical decline and muscle homeostasis. Nature Communications, 12(1), 470. https://www.nature.com/articles/s41467-020-20790-0 (2021). Mitohormesis in hypothalamic POMC neurons mediates regular exercise-induced high-turnover metabolism. Cell Metabolism, 33(2), 334–349. https://www.sciencedirect.com/science/article/pii/S1550413121000036 (2018). The mitochondrial-encoded peptide MOTS-c translocates to the nucleus to regulate nuclear gene expression in response to metabolic stress. Cell Metabolism, 28(3), 516–524. (2021). Mitochondrial-encoded MOTS-c prevents pancreatic islet destruction in autoimmune diabetes. Cell Reports, 36(4), 109447. MOTS-c Coordinates Inter-Organellar Proteostasis for Adaptation to Chronic Metabolic Stress https://www.biorxiv.org/content/10.64898/2026.06.22.733272v1 Qitone (10% off: HEALTH10) https://tidd.ly/4jGklry Qitone Esters Powder Seeking Health supplements: 10% discount code Richard10 https://crrnt.app/SEEK/-dm0MyrQ, Histamine Nutrients https://crrnt.app/SEEK/EpM7paAO AX3 Life Astaxanthin 20% discount code MODERN20 https://tinyurl.com/2t3w26nw https://www.choosemuse.com Stemregen 15% discount Code MODERN https://tinyurl.com/45z968yr (Only available in the US) Renue by Science all 10% discount with code MHS https://renuebyscience.com/ Nuchido Time+ 20% discount of first purchase with code MODERN20 https://nuchido.com/MODERN If you would like to support our channel please consider signing up on patreon https://patreon.com/ModernHealthspan You can also find us on YouTube at https://www.youtube.com/c/modernhealthspan

Discover how AI-guided Cardiac CT scanning detects hidden soft plaque and allows preventive cardiology to track and reverse heart disease before symptoms start Cardiovascular disease remains the leading cause of mortality worldwide, yet over half of affected individuals experience no warning signs before a major event. In this deep-dive interview, Dr. John Osborne, triple-board-certified preventive cardiologist and Chief Medical Officer at ClearCardio, outlines a paradigm shift from reactive symptom management to proactive disease eradication. Dr. Osborne explains why traditional blood panels and risk calculators often fail at the individual level, how arteries hide soft plaque through outward remodeling, and why standard calcium scores can offer a dangerous false sense of security. Discover how cutting-edge AI-enhanced Coronary CT Angiography (CCTA) allows clinicians to visualize, map, and measure arterial plaque down to $0.1mm. Learn how tailored lifestyle strategies, lipid management, and emerging therapeutics targeting Lp(a) can stabilize and reverse plaque to optimize long-term healthspan. 🌐Links in this video ClearCardio Web Page: https://clearcardio.com/ ClearCardio YouTube Channel : https://www.youtube.com/@ClearCardio PREVENT Online calculator - https://professional.heart.org/en/guidelines-and-statements/prevent-calculator Qitone (10% off: HEALTH10) https://tidd.ly/4jGklry Qitone Esters Powder Seeking Health supplements: 10% discount code Richard10 https://crrnt.app/SEEK/-dm0MyrQ, Histamine Nutrients https://crrnt.app/SEEK/EpM7paAO AX3 Life Astaxanthin 20% discount code MODERN20 https://tinyurl.com/2t3w26nw https://www.choosemuse.com Stemregen 15% discount Code MODERN https://tinyurl.com/45z968yr (Only available in the US) Renue by Science all 10% discount with code MHS https://renuebyscience.com/ Nuchido Time+ 20% discount of first purchase with code MODERN20 https://nuchido.com/MODERN If you would like to support our channel please consider signing up on patreon https://patreon.com/ModernHealthspan You can also find us on YouTube at https://www.youtube.com/c/modernhealthspan

Discover how original Yamanaka co-author Dr. Koji Tanabe uses automated iPSC cassettes and autologous stem cell secretomes to reverse cellular aging and repair damaged joints. In this landmark episode of Modern Healthspan, we sit down with Dr. Koji Tanabe, founder and CEO of iPS, Inc. and co-author of the historic 2007 Nobel Prize-winning paper on human-induced pluripotent stem cells (iPSCs). Dr. Tanabe shares how twenty years of technological advancement have raised iPSC reprogramming efficiency from under 1% to over 80%, while cutting manufacturing costs through automated cleanroom cassettes. We discuss practical longevity applications available today, including autologous stem cell banking from a simple blood draw, secretome extract therapies for joint and skin rejuvenation, and Japan's approval of iPSC-derived heart tissue. Finally, Dr. Tanabe offers a critical scientific perspective on in vivo partial reprogramming, detailing the cellular identity loss and tumor risks associated with OSK gene delivery. Watch now to learn where stem cell age reversal truly stands today. 🌐Links in this video I Peace home page https://ipeace.com/en/ For Individuals https://mypeace-personal-ipscbanking.com/en/ Dr Tanabe's YouTube channel: https://www.youtube.com/@UC7Vjvz6sM1Olcw_NOXPIkCw *Scientific Backing & Citations:* 1. Takahashi, K., Tanabe, K., Ohnuki, M., Narita, M., Ichisaka, T., Tomoda, K., & Yamanaka, S. (2007). Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell, 131(5), 861-872. https://doi.org/10.1016/j.cell.2007.11.019 2. Life Biosciences' ER100 In Vivo Partial Reprogramming Phase 1 Clinical Trial (FDA Cleared). 3. Japanese Act on the Safety of Regenerative Medicine (ASRM) (regulatory framework for autologous cellular extract medical services). Qitone (10% off: HEALTH10) https://tidd.ly/4jGklry Qitone Esters Powder Seeking Health supplements: 10% discount code Richard10 https://crrnt.app/SEEK/-dm0MyrQ, Histamine Nutrients https://crrnt.app/SEEK/EpM7paAO AX3 Life Astaxanthin 20% discount code MODERN20 https://tinyurl.com/2t3w26nw https://www.choosemuse.com Stemregen 15% discount Code MODERN https://tinyurl.com/45z968yr (Only available in the US) Renue by Science all 10% discount with code MHS https://renuebyscience.com/ Nuchido Time+ 20% discount of first purchase with code MODERN20 https://nuchido.com/MODERN If you would like to support our channel please consider signing up on patreon https://patreon.com/ModernHealthspan You can also find us on YouTube at https://www.youtube.com/c/modernhealthspan

Discover the truth about population-wide NAD+ optimization with Dr. Jin-Xiong She from Jinfinity Precision Medicine. We break down the clinical flaws behind the recent Janssen and Houtkooper human blood study claiming NAD levels do not decline with age or lifestyle habits. Learn how ethnicity, health status, NMN vs. NR synergies, and high-dose niacin vascular inflammation impact intracellular biomarkers, and discover the true optimal blood reference target for healthy aging. Does human NAD+ actually decline with age, and do popular precursors like NMN or NR work for everyone? In this episode of Modern Healthspan, we sit down with clinical frameworks pioneer Dr. Jin-Xiong She, founder of Jinfinity Precision Medicine, to dissect recent human trial publications. Dr. She critiques a controversial recent paper asserting that blood NAD+ remains static across age groups, exposing its narrow testing intervals and misleading over-generalizations. Drawing from thousands of independent patient datasets, Dr. She details the sharp, non-linear NAD drop off that occurs between ages 20 and 30, while revealing the hidden impacts that ethnicity and background health status have on your baseline cellular metrics. We also explore the optimal human blood target range, shifting from a baseline of 40 µmol to a clinical sweet spot between 55 and 80 µmol, and highlight the surprising cardiovascular inflammation risks linked to over-supplementing with high-dose niacin 🌐Links in this video https://www.jinfiniti.com/ Qitone (10% off: HEALTH10) https://tidd.ly/4jGklry Qitone Esters Powder Seeking Health supplements: 10% discount code Richard10 https://crrnt.app/SEEK/-dm0MyrQ, Histamine Nutrients https://crrnt.app/SEEK/EpM7paAO AX3 Life Astaxanthin 20% discount code MODERN20 https://tinyurl.com/2t3w26nw https://www.choosemuse.com Stemregen 15% discount Code MODERN https://tinyurl.com/45z968yr (Only available in the US) Renue by Science all 10% discount with code MHS https://renuebyscience.com/ Nuchido Time+ 20% discount of first purchase with code MODERN20 https://nuchido.com/MODERN If you would like to support our channel please consider signing up on patreon https://patreon.com/ModernHealthspan You can also find us on YouTube at https://www.youtube.com/c/modernhealthspan