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In this podcast episode, Dr Jonathan Meyer answers additional questions from learners at our Psychopharmacology Update conference. Questions explore other disease states where psychosis can occur, practical considerations around special populations, tolerability, drug combinations, and the potential future of muscarinic-based therapies. For additional activities in this program including a ClinicalThought commentary, a CME/CE/CPE certified on-demand webcast and a downloadable slideset, go to: https://bit.ly/4qjcYcj Faculty: Jonathan M. Meyer, MD, DLFAPA Voluntary Clinical Professor of Psychiatry University of California, San Diego Senior Academic Adviser California Department of State Hospitals San Diego, California Get access to all of our new podcasts by subscribing to the CCO Neuroscience Podcast on Apple Podcasts, YouTube Podcasts, or Spotify. Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

In this episode of “Cognitive Conversations,” expert faculty discuss breaking data presentations from the 2026 Clinical Trials on Alzheimer’s Disease conference held in San Diego, California, from December 1-4, 2025, and their implications for clinical practice. Topics covered include: Evoke and evoke+ phase III trials of semaglutideSubcutaneous lecanemab as initiation and maintenance treatmentBlood-based biomarker assaysTrontinemab and other brain shuttlesTau targeting therapies in developmentPreventive impact of BCG and herpes zoster vaccinationThis podcast episode is part of the CME/CE-accredited program, “Early Clues, Lasting Impact: Detecting and Treating Alzheimer’s Disease in Its Earliest Stages,” supported by an educational grant from Novo Nordisk.  Faculty: Anton P. Porsteinsson, MD  William B. and Sheila Konar Professor of Psychiatry, Neurology, and Neuroscience, and Medicine Director, Alzheimer's Disease Care, Research and Education Program (AD-CARE) University of Rochester School of Medicine and Dentistry Rochester, New York Vijay K. Ramanan, MD, PhD Consultant and Associate Professor Director, Alzheimer’s Disease Treatment Clinic Department of Neurology Mayo Clinic Rochester, Minnesota  Link to obtain CME/CE credit:  https://bit.ly/4999otE Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

In this podcast episode, epilepsy specialists Danielle Becker, MD, MS, FAES, and Sarah Weatherspoon, MD, discuss the personalization of the most recently available epilepsy rescue treatments for younger kids and their implementation by the patient care team. Faculty: Danielle Becker, MD, MS, FAES  Division Director of Epilepsy Associate Professor of Neurology The Ohio State University Wexner Medical Center Columbus, Ohio  Sarah Weatherspoon, MD Associate Chief of Child Neurology Tuberous Sclerosis Center of Excellence, Neurology Co-Director Le Bonheur Children's Hospital University of Tennessee Health Science Center Memphis, Tennessee Resources mentioned in this episode: Epilepsy Foundation Seizure Action Plan ToolkitCDC Managing Epilepsy Well (MEW) NetworkLink to Brain Health Hub with additional educational activities:  https://bit.ly/3Y12Isx Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

In this episode, Alireza Atri, MD, PhD, discusses his approach to patient conversations on brain health and provides advice to healthcare professionals practicing in community neurology settings, in a dialogue with Robin Martinez, a patient advocate from the Smart Patients online community. Supported by an educational grant from Lilly. Faculty: Alireza Atri, MD, PhD  Chief Medical Officer, Banner Research Phoenix, Tucson and Sun City, Arizona Director, Banner Sun Health Research Institute Sun City, Arizona Robin Martinez Patient Advocate Coordinator of Online Communities Website Administration Smart Patients Inc. Denver, Colorado Resources mentioned in this episode: Alzheimer’s Association: DETeCD-ADRD Clinical Practice Guidelines for Specialty Care  https://bit.ly/4kqtYt5American Geriatrics Society: 2023 Beers Criteria for Potentially Inappropriate Medication Use in Older Adults  https://bit.ly/44zN8qGMoCA (Montreal Cognitive Assessment) : [Link to: https://mocacognition.com/]Link to obtain CME/CE credit:  https://bit.ly/44khuP5 Link to Brain Health Hub with additional educational activities: https://bit.ly/4kziu6T Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

In this episode, dementia expert Anton Porsteinsson, MD, discusses his approach to conversations on brain health with patients and provides guidance for HCPs practicing in community psychiatry settings, in a dialogue with Robin Martinez, a patient advocate from the Smart Patients online community. Supported by an educational grant from Lilly. Faculty: Anton P. Porsteinsson, MD  William B. and Sheila Konar Professor of Psychiatry, Neurology, Neuroscience, and Medicine Director, Alzheimer’s Disease Care, Research and Education Program (AD-CARE) University of Rochester School of Medicine and Dentistry Rochester, New York Robin Martinez Patient Advocate Coordinator of Online Communities Website Administration Smart Patients Inc. Denver, Colorado Resources mentioned in this episode: Mini Mental State Examination (MMSE) [Link to: https://www.psychdb.com/_media/mmse.]Mini-Cog (quick dementia screening test) [Link to: https://mini-cog.com/]MoCA (Montreal Cognitive Assessment) : [Link to: https://mocacognition.com/]Alzheimer’s Association Local Chapters [Link to:https://www.alz.org/chapter-search]Local Department of Aging [Link to : https://www.thecountyoffice.com/department-of-aging/]Link to obtain CME/CE credit:  https://bit.ly/3IAbyc7 Link to Brain Health Hub with additional educational activities:  https://bit.ly/40Jgth4   Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

In this episode, Genevieve Neal-Perry, MD, PhD, discusses her approach to conversations on brain health with her patients in obstetrics and gynecology settings, in a dialogue with Robin Martinez, a patient advocate from the Smart Patients online community. Supported by an educational grant from Lilly. Faculty: Genevieve Neal-Perry, MD, PhD  Robert A. Ross Distinguished Professor Chair of Obstetrics and Gynecology University of North Carolina School of Medicine Chapel Hill, North Carolina Robin Martinez Patient Advocate Coordinator of Online Communities Website Administration Smart Patients Inc. Denver, Colorado Resources mentioned in this episode: Smart Patients, an online community for patients and their families [Link to: https://www.smartpatients.com/]Link to obtain CME/CE credit:  https://bit.ly/4lH4BEt Link to Brain Health Hub with additional educational activities: https://bit.ly/4nJrgSG Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

In this episode, Pierre N. Tariot, MD, discusses his approach to conversations on brain health with his patients and their family members in primary care settings, in a dialogue with Robin Martinez, a patient advocate from the Smart Patients online community. Supported by an educational grant from Lilly. Faculty: Pierre N. Tariot, MD Director Banner Alzheimer's Institute Research Professor of Psychiatry University of Arizona College of Medicine Phoenix, Arizona Robin Martinez Patient Advocate Coordinator of Online Communities Website Administration Smart Patients Inc. Denver, Colorado Resources mentioned in this episode: Banner Alzheimer InstituteECHO (Extension for Community Healthcare Outcomes)MoCA (Montreal Cognitive Assessment)Mini-Cog (quick dementia screening test)FDA Clears First Blood Test Used in Diagnosing Alzheimer’s DiseaseLancet Commission: Dementia Prevention, Intervention, and Care 2024Link to obtain CME/CE credit: https://bit.ly/4kk1vFs Link to Brain Health Hub with additional educational activities: https://bit.ly/3H4hoSl Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

In this episode, Susan Scanland, MSN, CRNP, GNP-BC, CDP, discusses her approach to conversations on brain health with her patients and their family members in clinical practice as a gerontological nurse practitioner, in a dialogue with Robin Martinez, a patient advocate from the Smart Patients online community. Supported by an educational grant from Lilly. Faculty: Susan Scanland, MSN, CRNP, GNP-BC, CDP CEO & Founder Dementia Connection LLC Clarks Summit, PennsylvaniaRobin Martinez Patient Advocate Coordinator of Online Communities Website Administration Smart Patients Inc. Denver, ColoradoResources mentioned in this episode: Alzheimer’s Association: 2025 Alzheimer’s Disease Facts and FiguresLancet Commission: Dementia Prevention, Intervention, and Care 2024American Geriatrics Society: 2023 Beers Criteria for Potentially Inappropriate Medication Use in Older AdultsAlzheimer’s Association: DETeCD-ADRD Clinical Practice Guidelines for Primary CareClinical Care Options: Integrating Brain Health Discussions Into Your Daily RoutineLink to obtain CME/CE credit: https://bit.ly/4mqHoaS Link to Brain Health Hub with additional educational activities: https://bit.ly/3H4hoSl Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Listen in as Cristina Mussini, MD; Martin Witzenrath, MD, FERS; and Michele Bartoletti, MD, PhD, discuss best practices in managing people who are immunocompromised with COVID-19 in the hospital setting, including:  COVID-19 burden among this populationInitial workup to assess disease severitySummary of COVID-19 guideline recommendationsA detailed patient case to illustrate key takeawaysPresenters: Michele Bartoletti, MD, PhD​ Associate Professor of Infectious Diseases Department of Biomedical Sciences Humanitas University Pieve Emanuele (MI), Italy Head of Infectious Diseases Unit IRCCS Humanitas Research Hospital Rozzano (MI), Italy Cristina Mussini, MD​ Full Professor of Infectious Diseases Chief of the Department of Infectious Diseases University of Modena and Reggio Emilia Modena, Italy Martin Witzenrath, MD, FERS Medical Director Charite Centrum 12 Internal Medicine & Dermatology Professor and Chair for Respiratory Medicine and Critical Care Department of Infectious Disease, Respiratory Medicine and Critical Care Charite Campus Mitte/Campus Virchow Klinikum/Campus Benamin Franklin Charite – University of Berlin Berlin, Germany Link to full program: https://bit.ly/4fs7Hcb Downloadable slides:  https://bit.ly/4imCRU5 Get access to all of our new podcasts by subscribing to the CCO Infectious Disease Podcast on Apple Podcasts, Google Podcasts, or Spotify. Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

In this episode, Dr Robert Cotes and Dr David Goldsmith discuss their clinical experience with long-acting injectable antipsychotic treatments in the Grady Health System, with a focus on communication strategies to educate patients on their treatment options and engage them in shared decision-making. Presenters:  Robert O. Cotes, MD, DFAPA Associate Professor and Distinguished Physician Director, Clinical & Research Program for Psychosis at Grady Health System Director, Project ARROW at Grady Health System Department of Psychiatry and Behavioral Sciences Emory University School of Medicine Atlanta, Georgia David R. Goldsmith, MD, MSc Associate Professor Director, Inflammation, Motivation, and Negative Symptoms of Schizophrenia (InMotioNSS) Lab Co-Director, Clinical & Research Program for Psychosis at Grady Health System Director, PSTAR Clinic at Grady Memorial Hospital Faculty, Emory Behavioral Immunology Program Co-Director, Psychiatry Residency Research Track Department of Psychiatry and Behavioral Sciences Emory University School of Medicine Atlanta, Georgia This content is part of an online CME program supported by educational grants from Indivior Inc.; Otsuka America Pharmaceutical, Inc. and Lundbeck; and Teva Pharmaceuticals.  Link to full program: https://bit.ly/414XkY4 Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

In this episode, David N. Lieberman, MD, PhD, and Eric Marsh, MD, PhD, discuss recent updates relevant to the treatment of Rett syndrome, including: The recently updated Comprehensive Care Guidelines from the International Rett Syndrome Foundation, available at rettsyndrome.orgOngoing collection and analysis of longitudinal data within the Rett Syndrome Natural History StudyEfficacy and safety data from the double-blind, placebo-controlled phase III registrational LAVENDER trial evaluating oral trofinetide, a small molecule analogue of insulin-like growth factor 1Topline results from phase III AVATAR and EXCELLENCE trials of the sigma-1 receptor agonist blarcamesineSeveral early ongoing gene therapy trialsDr Lieberman and Dr Marsh complement this informative update with wisdom from their own clinical experience to provide a full picture of current treatment and management options available to patients with Rett syndrome. Presenters:  David N. Lieberman, MD, PhD Director, Comprehensive Rett Syndrome Clinic Department of Neurology Boston Children's Hospital Boston, Massachusetts Eric Marsh, MD PhD Clinical Director, Orphan Disease Center Director (MPI), CHOP/Penn IDDRC Professor, Departments of Neurology and Pediatrics Division of Neurology Children’s Hospital of Philadelphia Perelman School of Medicine University of Pennsylvania Philadelphia, Pennsylvania This content is part of an online CME program in partnership with the International Rett Syndrome Foundation and supported by an educational grant from Acadia Pharmaceuticals. Link to full program: https://bit.ly/4fJRRL0 Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Link to CME: Claim Credit - https://bit.ly/3OByCaE In this episode, Drs. Halford and Hahn discuss the current treatment landscape of developmental and epileptic encephalopathies (DEEs), such as Lennox-Gastaut syndrome and Dravet syndrome, and the emerging role of brain cholesterol in addressing seizure frequency. The full episode covers: How to diagnose these epilepsies and the FDA-approved treatment options in the first-line and second-line settingsThe role of antiseizure medications in DEE treatment managementThe nonpharmacological treatment options available to patients with DEEsThe emerging role of brain cholesterol in neurologic diseases like DEEs and Alzheimer’s diseaseResults from the ELEKTRA clinical trial, including cholesterol synthase inhibitors’ impact on seizure frequencyThe future of soticlestat as a treatment option for pediatric patients with DEEsPresenters: Jonathan J. Halford, MD Professor Director, Translational Research Unit Department of Neurology Medical University of South Carolina Charleston, SC Cecil Hahn, MD, MPH, FRCPC Professor Pediatric Epileptologist University of Toronto Toronto, Ontario, Canada Content based on an online CME program supported by an independent educational grant from Takeda Pharmaceuticals U.S.A., Inc. Link to full program:  https://bit.ly/45UUpQy Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Link to CME: Claim Credit - https://bit.ly/3wbVkA1 In this episode, Drs. Halford and White discuss the emerging role of brain cholesterol in the development and potential treatment of neurological diseases like epilepsy or Alzheimer and Huntington diseases. The full episode covers: Overview of brain cholesterol and its function in the bodyPathogenesis potential for certain diseases via brain cholesterolEmerging research on a cholesterol synthase inhibitor as a novel therapyThe future of soticlestat as a potential treatment option for pediatric epilepsies—Lennox-Gastaut syndrome and Dravet syndrome—and other neurological diseasesPresenters: Jonathan J. Halford, MD Professor Director, Translational Research Unit Department of Neurology Medical University of South Carolina Charleston, SC H. Steve White, PhD Professor, Department of Pharmacy Co-Director, Center for Epilepsy Drug Discovery School of Pharmacy University of Washington Seattle, Washington Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

In this episode, Drs. Sabbagh and Isaacson discuss how to best approach Alzheimer’s disease (AD) and mild cognitive impairment (MCI) in clinical practice, including accurately diagnosing patients and optimizing treatment in terms of patient preferences and reimbursement options. The full episode covers: Defining AD and MCI and their clinical presentationHow to diagnose AD vs MCIReimbursement landscape for current diagnosing and monitoring toolsPrecision medicine’s evolving role in diagnosing and treating patients with AD and/or MCI  Presenters: Marwan Sabbagh, MD Professor of Neurology Alzheimer’s and Memory Disorders Division Department of Neurology Barrow Neurological Institute Phoenix, Arizona Richard Isaacson MD Director of the Institute for Neurodegenerative Diseases Florida   Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

The treatment landscape of major depression is increasingly shifting from monoaminergic agents to agents that modulate glutamate and GABA. Healthcare professionals need to stay up to date and educated on these changes in order to discuss the most current treatment options with their patients. In this podcast episode, we interview Dr Anita Clayton, a clinician researcher who has been involved in some of the clinical trials for these novel glutamatergic and GABAergic medications, and ask her key questions about mechanism of action and clinical application. Listeners will come away from this podcast episode more informed and more excited for the future of major depression care.  Presenters: Anita Clayton, MD David C. Wilson Professor and Chair Department of Psychiatry and Neurobehavioral Sciences Professor of Clinical Obstetrics and Gynecology University of Virginia School of Medicine Charlottesville, Virginia This podcast episode is supported by an educational grant from Sage Therapeutics, Inc. and Biogen. Link to full program: https://bit.ly/3YdPMPa Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.