Advertise on podcast: Alexander Disease Research Update

Send us Fan Mail Albee Messing and Abby Olsen discuss the following recent publication: Adult-Onset Alexander Disease Presenting as Atypical Parkinsonism and Autonomic Dysfunction: A Case Series Journal of Clinical Medicine, 15, 5677 (2026) Send your questions and feedback to:  [email protected] Help support research on Alexander Disease at the University of Wisconsin-Madison's Waisman Center:             https://alexander-disease.waisman.wisc.edu/donate/ Podcasts supported by Daniel's Fight (https://www.danielsfight.org/) #alexanderdisease #alexanderdiseaseresearch

Send us Fan Mail Albee Messing and Aidan Long discuss the following recent publication:  Demonstrating clinical and radiological variability of adult-onset Alexander disease in three siblings                   Journal of the Neurological Sciences 489, 126109 (2026)                   https://pubmed.ncbi.nlm.nih.gov/42501499/ Send your questions and feedback to:  [email protected] Help support research on Alexander Disease at the University of Wisconsin-Madison's Waisman Center:           https://alexander-disease.waisman.wisc.edu/donate/ Podcasts supported by Daniel's Fight (https://www.danielsfight.org/) #alexanderdisease #alexanderdiseaseresearch

Send us Fan Mail Albee Messing, Jared Cullen, and Nadine Connor discuss the following recent publication:  Behavioral characterization of bulbar sensorimotor function in a rat model of Alexander disease                   Behavioural Brain Research (in press)  Send your questions and feedback to:  [email protected] Help support research on Alexander Disease at the University of Wisconsin-Madison's Waisman Center:            https://alexander-disease.waisman.wisc.edu/donate/ Podcasts supported by Daniel's Fight (https://www.danielsfight.org/) #alexanderdisease #alexanderdiseaseresearch

Send us Fan Mail Albee Messing and Ylenia Vaia discuss the following recent publication:  Neuroradiological patterns and prognostic implications in type I Alexander disease Molecular Genetics and Metabolism, 148, 110189 (2026) Send your questions and feedback to:  [email protected] Help support research on Alexander Disease at the University of Wisconsin-Madison's Waisman Center:           https://alexander-disease.waisman.wisc.edu/donate/ Podcasts supported by Daniel's Fight (https://www.danielsfight.org/)

Send us Fan Mail Albee Messing, Dolores Pérez-Sala, and Natasha Snider discuss the following recent publications:  Alexander disease mutations differentially sensitize glial fibrillary acidic protein (GFAP) to posttranslational modifications and network disruption by oxidants.                   Redox Biology 92:104103 (2026)   Lysosomal function, resistance to oxidative stress and repair are compromised by expression of the Alexander disease GFAP R239C mutant.                   Free Radical Biology & Medicine (in press) Send your questions and feedback to:  [email protected] Help support research on Alexander Disease at the University of Wisconsin-Madison's Waisman Center:             https://alexander-disease.waisman.wisc.edu/donate/   Podcasts are supported by Daniel's Fight (https://www.danielsfight.com)

Send us Fan Mail Albee Messing, Annette Bley, and Nadia Kokaly discuss the following recent publication:  [01:58]       Description of the Hamburg Alexander Leukodystrophy Cohort-Insights into Practical Classification and the Care Situation.  Journal of Clinical Medicine 14, 6918 (2025)   [19:00]       Comment: Peer review – please come home.  Send your questions and feedback to:  [email protected] Help support research on Alexander Disease at the University of Wisconsin-Madison's Waisman Center:             https://alexander-disease.waisman.wisc.edu/donate/   Podcasts are supported by Daniel's Fight (https://www.danielsfight.com).

Send us Fan Mail Albee Messing, Debra Levin, and Amy Waldman discuss the following recent publications:  [01:27]       Language Skills in Patients With Alexander Disease.  American Journal of Speech-Language Pathology 35:211-225 (2025)  [17:06]       Characterization of Clinical Phenotype to Glial Fibrillary Acidic Protein Concentrations in Alexander Disease.  Annals of Clinical and Translational Neurology (in press) [full text] Send your questions and feedback to:  [email protected] Podcasts supported by Daniel's Fight.  Help support research on Alexander Disease at the University of Wisconsin-Madison's Waisman Center:           https://alexander-disease.waisman.wisc.edu/donate/

Send us Fan Mail Albee Messing and Amanda Nagy discuss the following recent publication:  [01:42]       Genotype-phenotype correlations of GFAP variants in type I Alexander disease subtypes Molecular Genetics & Metabolism 147, 109689 (2026) Please send questions and feedback to:  [email protected] Help support research on Alexander Disease at the University of Wisconsin-Madison's Waisman Center:             https://alexander-disease.waisman.wisc.edu/donate/

Send us Fan Mail Albee Messing, Tracy Hagemann, and Abby Olsen discuss the following recent publication:  [01:45]       Growth Differentiation Factor 15 Elevation in the Central Nervous System Is Associated With Failure to Thrive in Alexander Disease Annals of Clinical and Translational Neurology (in press) [full text] Send your questions and feedback to:  [email protected] Help support research on Alexander Disease at the University of Wisconsin-Madison's Waisman Center:             https://alexander-disease.waisman.wisc.edu/donate/

Send us Fan Mail Albee Messing, Mel Feany, and Natasha Snider discuss the following recent publication:  Genotype-phenotype association for 14 GFAP variants in Alexander disease.  Neurology: Genetics. 11, e200270 (2025) [full text]   Send your questions and feedback to:  [email protected] Help support research on Alexander Disease at the University of Wisconsin-Madison's Waisman Center:             https://alexander-disease.waisman.wisc.edu/donate/         1.      Berman RF, Matson MR, Bachman AM, Lin N-H, Coyne S, Frelka A, et al. GFAP mutation and astrocyte dysfunction lead to a neurodegenerative profile with impaired synaptic plasticity and cognitive deficits in a rat model of Alexander disease. eNeuro:(in press) (2025)   PMID: 40064497   Isolation of Intermediate Filament Proteins from Multiple Mouse Tissues to Study Aging-associated Post-translational Modifications   J Vis Exp, 18, 55655 (2017) STAT3 Drives GFAP Accumulation and Astrocyte Pathology in a Mouse Model of Alexander Disease   Cells, 12, 978 (2023) A defined roadmap of radial glia and astrocyte differentiation from human pluripotent stem cells   Stem Cell Reports, 18, 1701-1720 (2023)

Send us Fan Mail Albee Messing, Tracy Hagemann, and Rob Berman discuss the following recent publication:  [02:01]       GFAP mutation and astrocyte dysfunction lead to a neurodegenerative profile with impaired synaptic plasticity and cognitive deficits in a rat model of Alexander disease eNeuro (in press)  [full text] Send your questions and feedback to:  [email protected] Help support research on Alexander Disease at the University of Wisconsin-Madison's Waisman Center:             https://alexander-disease.waisman.wisc.edu/donate/

Send us Fan Mail Albee Messing, Charlie Wade, and Mel Feany discuss the following recent publication:  [01:50]       Analysis of GFAP variants in UK Biobank suggests underdiagnosis or incomplete penetrance of adult-onset Alexander disease Journal of Neurology, Neurosurgery, and Psychiatry (in press)  Please send your questions and feedback to:  [email protected] Help support research on Alexander Disease at the University of Wisconsin-Madison's Waisman Center:            https://alexander-disease.waisman.wisc.edu/donate/

Send us Fan Mail Albee Messing and Natasha Snider discuss the following recent publications:  [01:04]       Aberrant neurodevelopment in human iPS cell-derived models of Alexander disease                   Glia (2024) (in press) [16:46]       A novel GFAP frameshift variant identified in a family with optico-retinal dysplasia and vision impairment Human Molecular Genetics (2024) (in press) Send your questions and feedback to:  [email protected] Help support research on Alexander Disease at the University of Wisconsin-Madison's Waisman Center:           https://alexander-disease.waisman.wisc.edu/donate/

Send us Fan Mail Albee Messing’s presentation at the recent Alexander disease conference in Philadelphia, August 3, 2024.  Send your questions and feedback to:  [email protected] Help support research on Alexander Disease at the University of Wisconsin-Madison's Waisman Center:             https://alexander-disease.waisman.wisc.edu/donate/

Send us Fan Mail Albee Messing, Amy Waldman, and Natasha Snider discuss the following recent publications:  [02:07]       A retrospective observational cohort study of the anesthetic management and outcomes of pediatric patients with Alexander disease undergoing lumbar puncture or magnetic resonance imaging                   Paediatric Anesthessia (in press)  [10:17]       Glial fibrillary acidic protein is pathologically modified in Alexander disease                   Journal of Biological Chemistry (in press) [full text] Send your questions and feedback to:  [email protected] Help support research on Alexander Disease at the University of Wisconsin-Madison's Waisman Center:           https://alexander-disease.waisman.wisc.edu/donate/       A retrospective observational cohort study of the anesthetic management and outcomes of pediatric patients with Alexander disease undergoing lumbar puncture or magnetic resonance imaging   Paediatric Anaesthesia, (in press) (2024)     Glial fibrillary acidic protein is pathologically modified in Alexander disease   Journal of Biological Chemistry, (in press) (2024)