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Rating

★★★★★

from

23 reviews

Description

Stan Crooke rose from poverty to found a company that pioneered antisense drugs. After decades of struggle and years of public doubt, the company created a treatment that has saved thousands of children from the brutal disease spinal muscular atrophy.

Podcast episodes

Check latest episodes from Hope Lies in Dreams podcast

Chapter 1: an ugly place

2021/09/08

Stan Crooke is born ⬩ A tenuous existence ⬩ Life with his mother ⬩ The Tech Corner ⬩ Arsenal Tech High School ⬩ Nancy ⬩ Hoodlum ways ⬩ Off to Purdue See acast.com/privacy for privacy and opt-out information.

Chapter 2: a winding path

2021/09/15

Quits Purdue ⬩ Pharmacy school ⬩ Off to Baylor ⬩ Harris Busch ⬩ Bristol Labs ⬩ SmithKline ⬩ The death of Nancy Crooke ⬩ The end of SmithKline See acast.com/privacy for privacy and opt-out information.

Chapter 3: San Diego restart

2021/09/22

Rosanne ⬩ An investor emerges ⬩ Founding Isis ⬩ The old garage ⬩ A proper space ⬩ A growing antisense scene ⬩ Starting a pipeline ⬩ Isis goes public See acast.com/privacy for privacy and opt-out information.

Chapter 4: three kinds of failure

2021/09/29

Stumbling out of the gate ⬩ Launch of Vitravene ⬩ Questions about antisense ⬩ The field thins ⬩ Clinical failure ⬩ The darkest days See acast.com/privacy for privacy and opt-out information.

Chapter 5: valley of antisense

2021/10/06

The genomics bubble ⬩ Affinitak fails ⬩ Lynne saves the company ⬩ Hybridon pivots ⬩ New chemistries ⬩ Regulus formed ⬩ Isis as cult See acast.com/privacy for privacy and opt-out information.

Chapter 6: lone voice in the wilderness

2021/10/13

Rosanne saves the company ⬩ Ibis is sold ⬩ An approval ⬩ Souring on Genzyme ⬩ The end of Genta ⬩ The discovery of the SMA gene See acast.com/privacy for privacy and opt-out information.

Chapter 7: the SMA gang

2021/10/20

The Larsons ⬩ The skunkworks project ⬩ The most unmet need ⬩ Instant synergy ⬩ Another first for antisense ⬩ The clinic, again ⬩ The achievements of Kathie Bishop See acast.com/privacy for privacy and opt-out information.

Chapter 8: part of something big

2021/10/27

Ethics lessons ⬩ Biogen re-ups ⬩ The ultimate sacrifice ⬩ FDA as partner ⬩ Emma’s phase 3 ⬩ Doug Kerr’s bright idea ⬩ Isis to Ionis ⬩ Spinraza approval See acast.com/privacy for privacy and opt-out information.

Chapter 9: the last of his kind

2021/11/03

Award season ⬩ NURTURE, and Gabriel ⬩ Kyle Derkowski’s new future ⬩ The drugs of SMA ⬩ Piece of magic ⬩ Frank’s Super Bowl See acast.com/privacy for privacy and opt-out information.

Chapter 10: Dr. Crooke

2021/11/10

The biggest deal ⬩ In the black ⬩ End of an era ⬩ n of 1 ⬩ Small places ⬩ A life of control ⬩ The doctor will see you now See acast.com/privacy for privacy and opt-out information.

Hope Lies in Dreams trailer

2021/09/01

Trailer for upcoming 10-part series, Hope Lies in Dreams. See acast.com/privacy for privacy and opt-out information.

Podcast reviews

Read Hope Lies in Dreams podcast reviews

5 out of 5

23 reviews

★★★★★

Schmid b a c 2022/05/16

Excellent story

This is a beautifully told story about a real pharma success. Highly recommend.

★★★★★

Burleith20007 2021/10/19

Great mix of science and storytelling

I’d never heard of antisense technology, nor its leading proponent — but this podcast makes it all compelling. Telling this tale of struggle — persona...

★★★★★

Kener1966-1976 2021/09/23

Excellency in motion

A clear picture of biomedical research is given on top of a sometimes wrenching personal story. The research pictures are completely true and bring m...

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