Advertise on podcast: The Metabolic Edge

Key Topics Covered The Next Frontier in Weight Loss: GLP-1s & Myostatin Inhibitors The Muscle Loss Problem: While GLP-1 receptor agonists (like Tirzepatide) are highly effective for weight loss, roughly 25% to 30% of the weight lost is actually lean body mass (muscle). The Pharmaceutical Solution: A recent Phase II clinical trial paired a GLP-1 drug with a myostatin inhibitor (which blocks the protein that caps muscle growth), successfully promoting lean mass development while shedding fat. The Practical Alternative: The hosts emphasize that resistance training and adequate protein intake achieve these exact same muscle-preserving results naturally, though large-scale studies on this are rarely funded because "you can't package and sell" exercise. The "Enhanced Games" & Tech-Bro Gladiators A critique of the upcoming "Enhanced Games"—an Olympic-style event where performance-enhancing drugs are openly allowed. Using baseball's historic steroid era (e.g., Mark McGwire and Sammy Sosa) as an example, they discuss how performance enhancers amplify raw power margins without actually replacing foundational athletic coordination. A humorous look at the logical extreme of this trend: transitioning from myostatin inhibitors to full-blown CRISPR genetic engineering, drawing parallels to the movie Gattaca. The Rise of "Wellness Burnout" Wellness Maxing: The multi-billion-dollar wellness industry has created a exhausting "firehose" of protocols, leaving people overwhelmed by red-light masks, cold plunges, complex morning supplement "stacks," and hyper-optimized mattress coolers. The Power of Subtraction: The hosts advocate for simplifying your health routine rather than adding to it. They recommend automating simple meal choices, hitting a baseline of 20 minutes of daily exercise, and finding community-based, accountable activities like pickleball to naturally reduce stress and fight social isolation.

Andrew and Tommy return from a long hiatus to discuss the rising popularity of peptides for weight loss, muscle gain, and various other health hacks.

What does the latest psychological research say about controlling your poorest eating habits? What simple strategies can you use to begin taking control of your diet? Tommy and Andrew answer these questions in the latest episode. Follow this link to apply for our medically integrated 12-week Immersion Weight Loss Program

Tommy and Dr.Appleton discuss the five most common cancer screening protocols, who should consider screening, and the downsides of each procedure. ⁠Follow this link ⁠to apply to our 12-Week Cardiometabolic Weight Loss Program

In this episode, Andrew and Tommy discuss the reductionist perspective on processed food by the medical and academic establishments as well as how the average person should consider food choices. Follow this link to apply to our 12-Week Cardiometabolic Weight Loss Program

Tommy and Andrew return with an episode on the connection between lifestyle and diseases of the brain. To apply to Tommy and Andrew's 12-Week Program, follow this link.

Tommy and Andrew cover a variety of relevant health and fitness topics in the latest random show. Follow⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ this link⁠⁠⁠⁠⁠⁠⁠ ⁠⁠⁠⁠⁠to apply to our 12-week weight-loss program (Serious inquiries only) Get the MetFlex-Rx Fat Loss Guide: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://amzn.to/2ZUeMBm⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Listen to Tommy's Behaviour Change Book on Audible and improve your healthy habits: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://amzn.to/3IjqEOJ⁠⁠⁠⁠⁠ Visit Andrew's Website https://andrewappletonmd.ca/

Andrew and Tommy return after a summer hiatus to catch up on their very important lives and remind listeners of how sleep quality effects both our waistlines, disease resilience, and other important health factors. Follow⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ this link⁠⁠⁠⁠⁠⁠⁠ ⁠⁠⁠⁠to apply to our 12-week weight-loss program (Serious inquiries only) Get the MetFlex-Rx Fat Loss Guide: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://amzn.to/2ZUeMBm⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Listen to Tommy's Behaviour Change Book on Audible and improve your healthy habits: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://amzn.to/3IjqEOJ⁠⁠⁠⁠ Visit Andrew's Website https://andrewappletonmd.ca/

In this episode, Tommy and Andrew discuss a variety of topics including: Marketing unhealthy foods to kids, how to make a genuine impact in government guidelines, and how poor sleep affects our ability to burn fat. Follow⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ this link⁠⁠⁠⁠⁠⁠⁠ ⁠⁠⁠to apply to our 12-week weight-loss program (Serious inquiries only) Get the MetFlex-Rx Fat Loss Guide: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://amzn.to/2ZUeMBm⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Listen to Tommy's Behaviour Change Book on Audible and improve your healthy habits: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://amzn.to/3IjqEOJ⁠⁠⁠ Visit Andrew's Website https://andrewappletonmd.ca/

Check out Tommy and Andrew's Latest "Ask Me Anything" episode. Questions asked and answered: What are blood tests you recommend an average person asks from their GP? Can you explain good carbs vs bad carbs? What are your thoughts on the daily recommended added sugar limits for kids? Do you have screen time rules for your children? If you could only do 3 exercises forever, what would they be? What’s a healthy body fat % for someone in their 40’s? How many meals should you eat in a day? What are your thoughts on the concept of blue zones? Get the MetFlex-Rx Fat Loss Guide: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://amzn.to/2ZUeMBm⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Listen to Tommy's Behaviour Change Book on Audible and improve your healthy habits: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://amzn.to/3IjqEOJ⁠⁠⁠ Follow⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ this link⁠⁠⁠⁠⁠⁠⁠ ⁠⁠⁠⁠to apply to our 12-week weight-loss program (Serious inquiries only) Visit Andrew's Website https://andrewappletonmd.ca/

Andrew an Tommy discuss updated research on GLP-1 Inhibitors (Wegovy, Ozempic, Zepbound, Mounjaro) while touching on the politics of food and the business of Big Pharma. Follow⁠⁠⁠⁠⁠⁠⁠⁠⁠ this link⁠⁠⁠⁠⁠⁠⁠ ⁠⁠to apply to our 12-week weight-loss program (Serious inquiries only) Get the MetFlex-Rx Fat Loss Guide: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://amzn.to/2ZUeMBm⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Listen to Tommy's Behaviour Change Book on Audible and improve your healthy habits: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://amzn.to/3IjqEOJ⁠⁠ Visit Andrew's Website https://andrewappletonmd.ca/

It what may be a world record for the longest amount of time spent getting to 50 episodes, we've done it. In this episode, Tommy and Andrew discuss the direction of the podcast content moving forward, share a bit about their current lifestyle approaches, and give insight into how to prioritize your health. Follow⁠⁠⁠⁠⁠⁠⁠⁠ this link⁠⁠⁠⁠⁠⁠⁠ ⁠to apply to our 12-week weight-loss program (Serious inquiries only) Get the MetFlex-Rx Fat Loss Guide: ⁠⁠⁠⁠⁠⁠⁠⁠⁠https://amzn.to/2ZUeMBm⁠⁠⁠⁠⁠⁠⁠⁠⁠ Listen to Tommy's Behaviour Change Book on Audible and improve your healthy habits: ⁠⁠⁠⁠⁠⁠⁠⁠⁠https://amzn.to/3IjqEOJ⁠ Visit Andrew's Website https://andrewappletonmd.ca/

In this episode, Tommy and Andrew cover the various psychological challenges driving the habits that leave us fat, sick, and self-loathing. Follow⁠⁠⁠⁠⁠⁠⁠ this link⁠⁠⁠⁠⁠⁠⁠ to apply to our 12-week weight-loss program (Serious inquiries only) Get the MetFlex-Rx Fat Loss Guide: ⁠⁠⁠⁠⁠⁠⁠⁠https://amzn.to/2ZUeMBm⁠⁠⁠⁠⁠⁠⁠⁠ Listen to Tommy's Behaviour Change Book on Audible and improve your healthy habits: ⁠⁠⁠⁠⁠⁠⁠⁠https://amzn.to/3IjqEOJ⁠

In this episode, Tommy and Andrew discuss what type of exercise requires recovery and the best techniques to ensure you're performing at your best. Follow⁠⁠⁠⁠⁠⁠ this link⁠⁠⁠⁠⁠⁠ to apply to the 12-week immersion program https://andrewappletonmd.ca/cmbh/ Get the MetFlex-Rx Fat Loss Guide: ⁠⁠⁠⁠⁠⁠⁠https://amzn.to/2ZUeMBm⁠⁠⁠⁠⁠⁠⁠ Listen to Tommy's Behaviour Change Book on Audible and improve your healthy habits: ⁠⁠⁠⁠⁠⁠⁠https://amzn.to/3IjqEOJ⁠

Questions asked and answered in our February AMA: I’m having trouble with my sleep schedule and it's affecting my morning workouts. Do you have tips for helping change/regulate sleep cycles and energy levels? What do you think of essential oils? My friends diffuse them because there seems to be a lot of health benefits. Does it really work or is it just a scam?  Do you guys consider eating a protein bar a good idea? If so, is there a certain bar that you would recommend? If not, how do I up my protein? Can eating too much protein cause gout?  Is a carnivore diet healthy? What vitamins and nutrients are missing? How do you connect oneself with more growth mindset oriented people when that’s not the norm? How does stress affect your ability to maintain as well as lose weight? Follow⁠⁠⁠⁠⁠⁠ this link⁠⁠⁠⁠⁠⁠ to apply to the 12-week immersion program https://andrewappletonmd.ca/cmbh/ Get the MetFlex-Rx Fat Loss Guide: ⁠⁠⁠⁠⁠⁠⁠https://amzn.to/2ZUeMBm⁠⁠⁠⁠⁠⁠⁠ Listen to Tommy's Behaviour Change Book on Audible and improve your healthy habits: ⁠⁠⁠⁠⁠⁠⁠https://amzn.to/3IjqEOJ⁠