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Look! It’s a follicular lymphoma! No wait, it’s a DLBCL! No wait, it’s a CLL? Actually is it a leukaemia? Join Nick, Cale and Bashar as they wrestle with the morphological and prognostic chameleon that is Mantle Cell Lymphoma. With all the bad bits of an indolent lymphoma and all the bad bits of an aggressive one – as Michael Jackson would say, it's bad (really, really bad). Except when it isn't. Who knows what mantle is doing – we don't think it knows itself TIMESTAMPS 0:57 - Conspiracies 101  3:47 - Epidemiology of MCL  6:41 - Morphology of MCL  7:41 - Flow cytometry for MCL  9:16 - Cyclin D1  14:49 - Risk Stratification for MCL  17:20 - Ki67 - what is it  19:15 - MRD for MCL?!  22:47 - Treatment of MCL  30:52 - Do we need an autoSCT?  33:20 - Leukaemic Non-Nodal MCL  36:27 - Cyclin D1 negative MCL  37:43 - Take Home Messages Support the show Check out show notes, additional references and (sometimes) extra content at www.bloodyminded.com.au

What do you call a small B-cell lymphoma that isn't CD5 positive, isn't CD10 positive and generally refuses to wear any of the usual hats? Probably marginal zone lymphoma. Possibly. Maybe. Join the Bloody Minded crew as we head to the edge of the follicle where the bloodstream's customs officers live, and look at what happens when they go rogue. Discover how to cure a cancer with a PPI, and why we're so very bored of the NF-κB pathway. TIMESTAMPS 0:57 - Whisky sponsorship pls and thx 2:11 - What the marginal zone is/isn't  6:28 - Marginal zone B cells 8:35 - Classifying marginal zone lymphoma 11:05 - Epidemiology 12:09 - Pathophysiology in gastric MALT 16:42 - Stimuli for other marginal lymphomas 19:55 - Pathological features of marginal 21:20 - Splenic MZL 25:43 - Flow cytometric features 30:13 - Workup of MZL 32:20 - Management strategies 37:53 - Prognosis 38:56 - High grade transformation 40:07 - Take home messages Support the show Check out show notes, additional references and (sometimes) extra content at www.bloodyminded.com.au

Join the boys as they frollickular through the molecular and macro-cular particulars of follicular lymphoma this week. While you're at it, please sign our petition to allow Bashar back into the aquarium and take a gander at Cale's tiny hands. Timestamps 00:52 - Bashar is banned from the Aquarium a second time 02:13 - Follicular Lymphoma Overview 06:07 - Pathophysiology of FL 09:50 - Follicular Lymphoma In Situ (Old Name) 11:54 - Clinical & Morphology 17:24 - Identifying FL in the Lab 20:08 - Staging & Workup 23:07 - Prognostication 25:56 - To treat or not to treat? 29:31 - Treating Upfront 33:59 - Treating Relapse 37:43 - Transformation 41:12 - Summary Support the show Check out show notes, additional references and (sometimes) extra content at www.bloodyminded.com.au

Why do haematologists get excited over smudges on a film? What is the deal with that whole IGHV situation? Why is Bashar no longer welcome at the zoo? Join us as we find the answers to these common haematology questions and more in a foray into Chronic Lymphocytic Leukaemia! TIMESTAMPS 0:55 - No animals were harmed in the making of this bit  4:13 - Epidemiology of CLL  5:56 - Pathophysiology of CLL  11:42 - MBL  12:36 - SLL  15:54 - Clinical features of CLL  18:18 - Lab features of CLL  20:50 - Flow cytometry for CLL  23:46 - Staging of CLL  25:38 - Prognostication of CLL  27:38 - Indications for treatment in CLL  31:04 - Treatment approaches for CLL  41:53 - Response assessment in CLL  42:49 - Richter's transformation  44:47 - Take Home Messages Support the show Check out show notes, additional references and (sometimes) extra content at www.bloodyminded.com.au

Welcome to the Land of the Lymphoid. Eighty-odd subtypes, one grid. Help us break our cellular pathways and journey further into our lymphoid season as we ask the only two questions that matter - B or T, fast or slow, forget the platypuses - and build the framework we'll be filling in for the rest of the series. Bring a hat, the savannah is hot.  0:52 - Lymphoid Planet 2:50 - Leukaemia vs Lymphoma 4:51 - Two Questions & A Recap 8:49 - Identifying a Cell 16:22 - Indolent vs Aggressive (and Super-Aggressive) 22:37 - Indolent B-Cell 23:21 - Aggressive B-Cell 25:27 - Indolent T-Cell 25:44 - Aggressive T-Cell 27:42 - Wait... what about Hodgkins 31:28 - A Framework 32:21 - General Lymphoma Workup 38:19 - Staging 40:12 - Review Support the show Check out show notes, additional references and (sometimes) extra content at www.bloodyminded.com.au

For the first time, Cale, Nick and Bashar have managed to maintain a contiguous thought across two different episodes and are returning to school - for the basics of immunology. But they’re not going back as teachers, no, the boys are going undercover as a naïve B-cell and following the journey to the lymph node. Will they be shunned to the uncool table like they were in high school? Can they avoid the murderous hunger games of the dark zone. Will they switch classes or somatically hypermutate? Find out on the next episode of 21 Ju… Lymph Node Street. TIMESTAMPS  0:53 - Disguise 101  5:10 - Naive B cells journey  7:56 - Lymph node anatomy refresher  13:31 - Activation of naive B cells  18:50 - Class switching  21:38 - Into the dark zone  24:45 - Diseases at the various stages of maturation  27:18 - Take Home Messages  Support the show Check out show notes, additional references and (sometimes) extra content at www.bloodyminded.com.au

Have you been asked to review “TLS” bloods?? Are you concerned the nursing staff are pranking you with haematology bloods that don’t include a FBC or coags? Why could you possibly want to look at something that isn’t a cell count? What crazy person decided after hours bloods needed to be collected on ICE? And WHY ?!?! Join us for an On The Wards approach to dealing with those TDS TLS SOS calls. TIMESTAMPS: 0:56 - The team breaking stuff 3:40 - Episode overview 5:07 - Setting the scene 6:33 - The history of TLS 7:28 - (nailed it) 8:00 - Pathophysiology of TLS 10:41 - Mechanisms of renal injury in TLS 11:39 - Clinical consequences of TLS 12:46 - Diagnostic criteria in TLS 15:10 - Clinical TLS vs lab TLS 15:35 - Grading TLS 16:55 - Other clues of TLS 18:09 - Who is at risk of TLS? 23:15 - Prevention of TLS 24:27 - Allopurinol 26:58 - Rasburicase 33:03 - Fluids fluids fluids 33:44 - Deciding who gets prophylaxis 35:50 - What ARE TLS bloods? 36:31 - What to do with a TLS on the ward 40:05 - Take home messages Support the show Check out show notes, additional references and (sometimes) extra content at www.bloodyminded.com.au

It’s the heaviest matter of haematology as we look at the role of heavy metals in our favourite metalloenzymes. What - you don’t have a favourite metalloenzyme?  But nothing else matters?! Anyway, this is no esoteric surgical content, join us as Nick, Cale and Bashar get comfy with the weirder parts of the periodic table and how they apply to less common deficiencies or toxicities in haematology. Look we’ll be honest with you - this is pretty low yield listening but it was fun, and really isn’t that point at the end of the day.  TIMESTAMPS 0:55 - Wacken Open Air or Bloody Minded? 3:58 - Molybdenum ft. Black Eyed Peas 11:07 - Copper ft. Calf Livers 14:41 - Zinc ft. Dentures 18:35 - Cobalt - ft. Goblins and Beer 22:40 - Lead ft. Basophilic Stippling 26:13 - Aluminium ft. Pronunciation Issues 28:29 - Take Home Messages Support the show Check out show notes, additional references and (sometimes) extra content at www.bloodyminded.com.au

Is it a giant Cthulu-esque sea monster? Is it an excellent Australian parody breakfast show? No - it’s everyone’s favourite (well everyone who counts) coagulation related Vitamin - Vitamin K! Where does it come from? Why is it so hard to find on the eMR when you want to prescribe it and what is it doing under phytomenadione? Can we test for it? After listening to Nick, Cale and Bashar wax lyrical about carboxylation for half an hour you’ll be ready to vitamin K-nock yourself out. TIMESTAMPS 0:53 - Birdsong 3:54 - The history of Vitamin K 10:02 - Types of Vit K 12:02 - K1 + K2 13:16 - K3 + K4 14:18 - K1-4 without the possession 15:46 - What does Vit K actually do? 19:37 - Dietary sources of Vit K 23:20 - Vit K Absorption Pathway 28:00 - Vit K + Gamma glutamyl carboxylase 33:20 - Practical aspects of Vit K replacement 38:48 - Take Home Messages Support the show Check out show notes, additional references and (sometimes) extra content at www.bloodyminded.com.au

Four humours in balance, the ancients decreed - so open a vein, let the bad blood be freed. From Galen to Harvey, from humours to genes,  From black bile and phlegm to the things on our screens. From PML::RARA to blood counts okay  Let’s celebrate our specialty - we’ve come a damn long way Join us as we travel from the first man to see a red cell, to the first to give people arsenic on purpose who was actually well-intentioned! Pour one out for Galen who was confidently incorrect for fifteen centuries but everyone just went with it anyway because it seemed pretty good at the time. We interrupt your scheduled haematinic programming for a historical grab bag and some chat about the podcast as we celebrate 100 episodes and still going strong.  TIMESTAMPS 1:49 - Sappy Stuff 7:15 - In the Beginning 9:52 - Leeches 12:57 - Harvey 14:43 - Microscopes 16:08 - Leukaemia 18:11 - Transfusion 20:30 - Anticoagulants 22:55 - Molecular 27:23 - Chemo 29:34 - Transplant 31:07 - Coags 33:07 - CAR-T 35:11 - Wrapup Support the show Check out show notes, additional references and (sometimes) extra content at www.bloodyminded.com.au

Two vitamins survived the great B-numbering cull to become the tests we order most and trust least. Meet the 80% of your B12 result your cells can't touch, and the antibody that sabotages the very test built to catch it. Join the Bloody Minded Crew as we come to the lab for a second time this season to learn how B12 and folate assays are performed.  TIMESTAMPS 0:55 - The boys check out a new lab  2:25 - Episode overview  3:43 - Sample requirements  4:12 - B12 refresher  6:03 - Total B12 assays  9:36 - Caveats in interpretation  14:00 - Active B12  15:59 - MMA and Homocysteine  18:13 - Folate testing  22:18 - Take home messages Support the show Check out show notes, additional references and (sometimes) extra content at www.bloodyminded.com.au

‘This bad boy can fit so much iron in it’ he said slapping the roof of a badly photoshopped molecule of apoferritin superimposed on a car. Is too much ferritin bad for you? Of course it is - too much is precisely the quantity that is in excess. But most of the time hyperferritinaemia has nothing to do with iron overload. Strap in to your 1992 Honda Civic as the Bloody Minded Crew learn all about ferritin, and why most of the time too much of it has nothing to do with your iron levels at all. Also join Cale specifically as he continues his vendetta against hepatology and their referrals.  Timestamps 0:59 - Bashar visits the salon 2:03 - Hyperferritinaemia overview 3:13 - Ferritin vs Iron Overload 6:08 - Signs and Symptoms associated with Hyperferritinaemia 10:50 - Causes of Hyperferritinaemia w/o Iron Overload 16:59 - Hyperferritinaemia w/ Iron Overload 21:30 - Chelation 22:43 - Erythoferrone 24:16 - Summary Support the show Check out show notes, additional references and (sometimes) extra content at www.bloodyminded.com.au

It's a BONUS episode today as the Bloody Minded Crew are delighted to partner with the Thrombosis and Haemostasis Society of Australia and New Zealand (THANZ). After (correctly) exiling Nick to another country after he suggested yet more coagulation themed episodes, he's returned like Gandalf stronger and more powerful than ever. We cornered THANZ members at the International Society for Thrombosis and Haemostasis 2026 meeting to chat about what was keeping them interested. Special thanks to Dr Danny Hsu, Dr Sara Ng, Dr George Mason, Dr Angela Huang, Dr Ibrahim Tohini-Esfahani, Dr Emily Powley, Dr Catherine Neal, Dr Marc Ellis, Dr Charithani Keragala, Hadley Bortz and Danielle Boyle for their contributions. Check out the THANZ website (www.thanz.org.au) and consider signing up if you're an Australian based scientist, clinician, nurse or allied health professional with an interest in Thrombosis and Haemostasis. There will be no show notes for this episode and our regular programming will continue as usual.  Support the show Check out show notes, additional references and (sometimes) extra content at www.bloodyminded.com.au

Nick wanted to talk about buckets all episode. I’ve convinced him to at least let us get angry at iron polymaltose, hypophosphatemia and nangs all over again. You don’t think you need this episode but you’d be amazed how many consults come through to Haem thinking we’re the gatekeepers of iron in the building. Ironic, really. TIMESTAMPS 0:56 - 1960s pop culture reference 3:20 - Episode overview 4:40 - Iron deficiency 6:28 - Pica chat 7:53 - Presentations of iron deficiency 8:36 - Causes of iron deficiency 11:10 - Taking a menstrual history 12:53 - Non-menstrual causes of iron deficiency 14:40 - Oral iron replacement 18:19 - IV iron replacement 25:01 - Folate deficiency 27:18 - Folate replacement 29:18 - B12 deficiency 31:19 - Causes of B12 deficiency 32:00 - Diagnosis of B12 deficiency 32:55 - B12 replacement 34:58 - Dealing with concurrent deficiencies 36:20 - Take home messages Support the show Check out show notes, additional references and (sometimes) extra content at www.bloodyminded.com.au

On the Ning Nang Nongs where the youths smoke bongs and the marrow all screams HELP! Join the Bloody Minded crew as they go through the round window, follow B12 and folate around the body in a Nang induced haze, presumably just like the writers on Play School once were.  Mandatory viewing: https://www.youtube.com/watch?v=3SUU1f3Mgpc&list=RD3SUU1f3Mgpc&start_radio=1 TIMESTAMPS 0:53 - A Bloody Minded After School Special 1:50 - Megaloblastic Anaemias 2:59 - An Intro to B12 7:49 - B12 Absorption 12:55 - Role of B12 15:07 - MMA + Homocysteine 16:40 - Causes of B12 Deficiency 20:04 - Nangs - Again 23:18 - Intro to Folate 25:32 - Folate Absorption 27:03 - Folate Deficiency 30:00 - Concurrent B12 + Folate Deficiency 32:18 - Take Home Messages Support the show Check out show notes, additional references and (sometimes) extra content at www.bloodyminded.com.au