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Episode 42 of the Performance Around The Clock podcast comes from the European Biological Rhythms Society Congress in Lubeck, Germany.  We are joined by Professor Ueli Schibler, an icon in the circadian field whose foundational discoveries helped establish fundamental principles in the field of circadian rhythms.    This episode explores Professor Schibler’s scientific journey, marked by serendipity and a philosophy of keeping an open mind to unexpected observations.  The conversation highlights how an initial failure to replicate a transcription factor experiment led to the groundbreaking realization that DBP (D-box binding protein) was the first mammalian transcription factor found to exhibit a circadian oscillation. We dive into his lab's revolutionary findings, including the surprise discovery that individual cells, such as fibroblasts, possess their own self-sustained circadian clocks that can be entrained by a simple serum shock.  Dr. Schibler and Panda also explore his seminal experiments demonstrating that food acts as a primary time-giver, or zeitgeber, capable of entraining circadian clocks in peripheral tissues like the liver. The discussion moves toward the profound clinical implications of his foundational work, touching upon the massive potential of chronotherapy to optimize cancer treatments, such as timing the delivery of PD-1 immune checkpoint inhibitors. Finally, Professor Schibler shares invaluable advice for young scientists about avoiding "bandwagon" research, and discusses his fascinating future hypotheses regarding cancer homeostasis and why germline DNA is virtually immortal. Please join us for this wide-ranging and inspiring conversation.  If you enjoy this episode, please like, comment, or subscribe. Thank you for listening. Guest:  Professor Ueli Schibler, University of Geneva 1984-2015 2013 Aschoff’s Rule Prize Winner 2012 Aschoff and Honma Prize Winner 2000 Louis-Jeantet Prize Winner 1996 Otto Naegeli prize for medicine Host:  Dr. Satchin Panda  X (Twitter): @SatchinPanda  https://x.com/SatchinPanda  Instagram: @satchin.panda https://www.instagram.com/satchin.panda/ Links:  Donations: https://panda.salk.edu/giving/  Research: https://www.salk.edu/scientist/satchidananda-panda/More science: ⁠https://mycircadianclock.org/⁠

In this episode of the Performance Around The Clock podcast, recorded at the European Biological Rhythms Society Congress in Lubeck, Germany, we are joined by Professor Rae Silver from Columbia University. Professor Silver is an iconic figure in circadian biology whose foundational research helped characterize the suprachiasmatic nucleus (SCN)—the brain's master circadian clock. We explore Professor Silver’s scientific journey, beginning with her early fascination with the perfectly timed, shared parental behaviors of doves and pigeons. The conversation highlights how this curiosity eventually led to her groundbreaking SCN transplant experiments in hamsters.  By transplanting the clock of a "fast-running" donor into a "slow-running" host, her work definitively proved that the SCN controls circadian behavior.  We dive into her revolutionary discovery that the SCN communicates its timing not just through neural synapses or "roads," but through "rivers and oceans"—secreting diffusible signals into the cerebrospinal fluid via a specialized portal blood vessel system. The discussion moves toward the profound clinical implications of this fluid communication network, including its connection to the brain's glymphatic system, waste clearance during sleep, and neurovascular diseases like Alzheimer's. We also touch upon the exciting future of the field, from the power of chronotherapy in optimizing cancer treatments to the massive economic and health benefits of lifestyle interventions like time-restricted eating and light management to combat diabetes. Finally, Professor Silver shares invaluable career advice for young scientists about balancing high-risk experiments with reliable projects, and the importance of cultivating a lifelong passion outside of the lab. Please join us for this wide-ranging and inspiring conversation. If you enjoy this episode, please like, comment, or subscribe. Thanks for listening. Guest:  Professor Rae Silver, Columbia University Helene L. and Mark N. Kaplan Professor of Natural & Physical Sciences Chair of the Neuroscience Program https://psychology.columbia.edu/content/rae-silver Host:  Dr. Satchin Panda  X (Twitter): @SatchinPanda  https://x.com/SatchinPanda  Instagram: @satchin.panda https://www.instagram.com/satchin.panda/ Links:  Donations: https://panda.salk.edu/giving/  Research: https://www.salk.edu/scientist/satchidananda-panda/  More science: ⁠https://mycircadianclock.org/⁠

In episode 40 of the Performance Around The Clock podcast, we are joined by Dr. Emily Manoogian, a leading clinical researcher focused on optimizing human health through the timing of food intake (time-restricted eating) and circadian rhythm regulation.  Dr. Manoogian was recently honored with the Young Investigator Award for her seminal studies on circadian disruption among shift workers and interventions to mitigate its effects. We begin the episode by defining the complex reality of shift work—whether fixed, rotating, or split shifts—and how working outside typical hours challenges the human body. Dr. Manoogian and Panda explore the cascading health effects of "circadian disruption," distinguishing between acute annoyances and chronic risks that build up over months and years. Dr. Manoogian explains how being active and eating when the body expects rest can lead to insulin resistance, cardiovascular disease, mood disorders, and even increased cancer risk. We also discuss the broader societal impacts, from the "social jetlag" affecting students and new parents to the unique stressors faced by frontline workers like firefighters and nurses. The conversation highlights actionable science, focusing on the "Healthy Heroes" study conducted with San Diego firefighters. Dr. Manoogian shares how Time-Restricted Eating (TRE)—limiting food intake to a 10-hour window—significantly reduced VLDL (bad cholesterol). reduced blood sugar levels, improved blood pressure and improved emotional stability in this high-stress population. Dr. Manoogian is currently studying a different shift work group with the ongoing "Shift Study" for nurses, which is using continuous glucose monitoring to test if optimizing meal timing and low-glycemic snacks can protect the cardiometabolic health of night-shift workers. Please join us for this vital discussion on optimizing health for those who keep our society running around the clock. If you enjoy this episode, please like, comment, or follow. Thanks for listening. Guest: Dr. Emily Manoogian Hillblom Fellow, Staff Scientist at the Salk Institute for Biological Studies Young Investigator Award Winner, Working Time Society myCircadianClock website: www.mycircadianclock.org Healthy HEROES study: https://pmc.ncbi.nlm.nih.gov/articles/PMC9536325/ SHIFT study: Participate by emailing: [email protected] Host: Dr. Satchin Panda X (Twitter): @SatchinPanda https://x.com/SatchinPanda Instagram: @satchin.panda https://www.instagram.com/satchin.panda/ Links: Donations: https://panda.salk.edu/giving/ Research: https://www.salk.edu/scientist/satchidananda-panda/ More science: ⁠https://mycircadianclock.org/⁠

In episode 39 of the Performance Around The Clock podcast, we are joined by Professor Alex Webb from the University of Cambridge, a leading expert in plant cell signaling and circadian clocks.  The episode was recorded at the XVIII Congress of the European Biological Rhythms Society in Lubeck, Germany.  Professor Webb shares his journey from psychology to plant physiology, discussing how a shared inspiration from researcher Andrew Miller led both him and also host Dr. Satchin Panda into the field of circadian rhythms. We explore the foundational history of biological clocks, starting with the 18th-century "wine cellar" experiment by De Mairan that first proved plants possess an internal oscillator. Professor Webb explains the complex behaviors of plants, such as the "yin and yang" of diurnal and nocturnal flowering to match pollinators, and the phenomenon of "sweaty plants"—how the circadian clock regulates stomata to balance carbon intake with water loss. We also discuss the metabolic math plants perform to survive the night, a process that explains why pumpkins actually grow in the dark. The conversation turns to "chronoculture," a concept focused on using circadian knowledge to optimize agriculture and meet the urgent goal of doubling food production by 2050. We examine how humans have inadvertently selected for clock mutations in crops like tomatoes and wheat—specifically the L3 gene—to adapt them to new environments. Finally, we discuss the "Plants for Space" program and how innovations in vertical farming for the International Space Station can teach us how to build sustainable, closed-loop food systems for our own "spaceship," Earth. Please join us for this fascinating discussion on the rhythms of the plant world. If you enjoy this episode, please like, comment or follow. Thanks for listening. Guest: Dr. Alex Webb Head of Circadian Signal Transduction Group University of Cambridge Profile: https://www.plantsci.cam.ac.uk/directory/alex-webb BlueSky: https://bsky.app/profile/alexwebblab.bsky.social Host: Dr. Satchin Panda X (Twitter): @SatchinPanda https://x.com/SatchinPanda Instagram: @satchin.panda https://www.instagram.com/satchin.panda/ Links: Donations: https://panda.salk.edu/giving/ Research: https://www.salk.edu/scientist/satchidananda-panda/More science: ⁠https://mycircadianclock.org/⁠

Episode 38 of the Performance Around the Clock features another guest from the XVIII Congress of the European Biological Rhythms Society in Lubeck, Germany. We are joined by Professor Andrew Miller, a Professor at the University of Edinburgh and the Chair of the Systems Biology Center for Engineering Biology. Professor Miller is a seminal figure in plant biology whose early work served as the inspiration for host Dr. Satchin Panda to enter the field of plant circadian rhythms.In this episode, we explore Professor Miller’s scientific journey, beginning with his fascination with interacting genetic systems and his move to New York to study plant-microbe symbiosis. The conversation highlights his groundbreaking development of rhythmic bioluminescence using the luciferase protein to visualize the plant clock in real-time. This innovation allowed researchers to identify the genes building the plant clock without killing the specimens, a technique that revolutionized the field.We dive into the critical role the circadian clock plays in agriculture, from measuring day length to trigger flowering to helping crops like barley adapt to the unique growing seasons of Scotland. Professor Miller also explains the fascinating connection between the clock and metabolic timing, detailing how plants use their internal timer to manage starch degradation overnight to avoid starvation before dawn.The discussion moves toward the future of the field, including the creation of "digital twins" through mathematical modeling to predict how specific genomes will perform in various climates. We also touch upon Professor Miller's work with the UK government's ACRE committee, advising on the policy and safety of genetically edited crops to meet the challenges of climate change and food security. Please join us for this wide-ranging and inspiring conversation. If you enjoy this episode, please like, comment, or subscribe. Thanks for watching.Guest:Dr. Andrew MillerUniversity of EdinburghProfessor of Systems BiologyChair of the Systems Biology Center for Engineering BiologyPaper highlight:Circadian clock mutants in Arabidopsis identified by luciferase imaginghttps://pubmed.ncbi.nlm.nih.gov/7855595/Host:Dr. Satchin PandaX (Twitter): @SatchinPandahttps://x.com/SatchinPandaInstagram: @satchin.pandahttps://www.instagram.com/satchin.panda/Links:Donations: https://panda.salk.edu/giving/Research: https://www.salk.edu/scientist/satchidananda-panda/More science: ⁠https://mycircadianclock.org/⁠

Episode 37 of the Performance Around the Clock comes from the XVIII Congress of the European Biological Rhythms Society in Lubeck, Germany.  We welcome Professor Anna Krook, a Professor of Integrative Physiology at the Department of Physiology and Pharmacology and chair of the Strategic Research Programme in Diabetes at Karolinska Institutet.  Professor Krook is an internationally recognized leader in metabolism, skeletal muscle and insulin biology.  In this episode, we discuss Professor Krook’s research journey, which began with her Ph.D. work on insulin and the insulin receptor gene, identifying rare mutations that cause severe inherited insulin resistance. She then focused on the dysregulation of insulin action seen in Type 2 diabetes, noting that muscle is the main site where insulin action goes wrong.  The conversation dives into the fascinating role of the circadian clock in regulating insulin, glucose, and muscle.  Dr. Krook explains that while healthy muscle mitochondria show a functional rhythm that peaks in the afternoon, this crucial rhythm is absent in muscle cells from people with Type 2 diabetes.  We cover her landmark study showing that for type 2 diabetic men doing high-intensity interval training, exercise in the afternoon led to lower blood glucose control and a beneficial "legacy effect" the next day. In contrast, morning exercise resulted in higher blood glucose levels for that entire day and the next. This negative effect may be linked to higher inflammatory markers and stress markers circulating in the plasma after morning exercise.  Please join us for an insightful conversation between Dr. Satchin Panda and Dr. Krook on optimizing exercise timing for metabolic health. If you enjoy this episode, please like, comment or follow. Thanks for listening. Guest: Dr. Anna Krook Karolinska Institutet Professor of Integrative Physiology Chair of the Strategic Research Programme in Diabetes Profile: https://ki.se/en/people/anna-krook Integrative Physiology group: ⁠https://ki.se/en/fyfa/integrative-physiology⁠ Paper highlight: Afternoon exercise is more efficacious than morning exercise at improving blood glucose levels in individuals with type 2 diabetes: a randomised crossover trial ⁠https://pubmed.ncbi.nlm.nih.gov/30426166/⁠ Host: Dr. Satchin Panda X (Twitter): @SatchinPanda https://x.com/SatchinPanda Instagram: @satchin.panda https://www.instagram.com/satchin.panda/ Links: Donations: https://panda.salk.edu/giving/ Research: https://www.salk.edu/scientist/satchidananda-panda/ More science: ⁠https://mycircadianclock.org/

Episode 37 of the Performance Around the Clock comes from the XVIII Congress of the European Biological Rhythms Society in Lubeck, Germany.  We welcome Professor Anna Krook, a Professor of Integrative Physiology at the Department of Physiology and Pharmacology and chair of the Strategic Research Programme in Diabetes at Karolinska Institutet.  Professor Krook is an internationally recognized leader in metabolism, skeletal muscle and insulin biology.  In this episode, we discuss Professor Krook’s research journey, which began with her Ph.D. work on insulin and the insulin receptor gene, identifying rare mutations that cause severe inherited insulin resistance. She then focused on the dysregulation of insulin action seen in Type 2 diabetes, noting that muscle is the main site where insulin action goes wrong.  The conversation dives into the fascinating role of the circadian clock in regulating insulin, glucose, and muscle.  Dr. Krook explains that while healthy muscle mitochondria show a functional rhythm that peaks in the afternoon, this crucial rhythm is absent in muscle cells from people with Type 2 diabetes.  We cover her landmark study showing that for type 2 diabetic men doing high-intensity interval training, exercise in the afternoon led to lower blood glucose control and a beneficial "legacy effect" the next day. In contrast, morning exercise resulted in higher blood glucose levels for that entire day and the next. This negative effect may be linked to higher inflammatory markers and stress markers circulating in the plasma after morning exercise.  Please join us for an insightful conversation between Dr. Satchin Panda and Dr. Krook on optimizing exercise timing for metabolic health. If you enjoy this episode, please like, comment or follow. Thanks for listening. Guest: Dr. Anna Krook Karolinska Institutet Professor of Integrative Physiology Chair of the Strategic Research Programme in Diabetes Profile: https://ki.se/en/people/anna-krook Integrative Physiology group: https://ki.se/en/fyfa/integrative-physiology Paper highlight: Afternoon exercise is more efficacious than morning exercise at improving blood glucose levels in individuals with type 2 diabetes: a randomised crossover trial https://pubmed.ncbi.nlm.nih.gov/30426166/ Host: Dr. Satchin Panda X (Twitter): @SatchinPanda https://x.com/SatchinPanda Instagram: @satchin.panda https://www.instagram.com/satchin.panda/ Links: Donations: https://panda.salk.edu/giving/ Research: https://www.salk.edu/scientist/satchidananda-panda/ More science: https://mycircadianclock.org/

Welcome to episode 36 of the Performance Around the Clock podcast. In this episode, Dr. Panda hosts Professor Geoff Wahl who is a renowned cancer scientist who conducted foundational research at the Salk Institute for 46 years. His long history in cancer research has focused on understanding the fundamental cellular and genetic mechanisms driving cancer, with an emphasis on the role of stem cells and the p53 tumor suppressor gene in breast and pancreatic cancers. Dr. Wahl also served as the president of the American Association of Cancer Research (AACR), utilizing the position to raise public awareness of the terrible toll of cancer and increase grassroots funding for research. Here, Professor Wahl highlights the crucial role of "foundational research" in combating cancer - explaining that cancer is a group of diseases, not a single one, where cells lose the ability to regulate division, with the most lethal factor being metastatic spread to distant organs. While research in breast cancer has led to effective targeted therapies for primary tumors, like Herceptin for HER2-positive cancers, there is a critical need for more research funding and a greater focus on understanding and treating metastatic cancers and intratumoral heterogeneity, which are major causes of mortality. Highlighting the value of funding foundational research, Dr. Tony Hunter’s work at the Salk Institute on tyrosine kinases has ultimately led to life-saving drugs like Gleevec, contributing to the 33% drop in the U.S. cancer death rate since 1991. We hope you enjoy this episode. If you want to support this channel, please like, comment, follow or donate. Thank you for listening. Guest: Dr. Geoff Wahl Professor Emeritus Salk Institute Profile: https://www.salk.edu/scientist/geoffrey-wahl/ Cancer statistics, 2023 https://pubmed.ncbi.nlm.nih.gov/36633525/ Host: Dr. Satchin Panda X (Twitter): @SatchinPanda https://x.com/SatchinPanda Instagram: @satchin.panda https://www.instagram.com/satchin.panda/ Links: Donations: https://panda.salk.edu/giving/ Research: https://www.salk.edu/scientist/satchidananda-panda/ More science: https://mycircadianclock.org/

Welcome to episode 35 of the Performance Around the Clock podcast. We’re joined by Dr. Hemal Patel, a distinguished Professor and Vice-Chair for Research in the Department of Anesthesiology at the University of California, San Diego (UCSD) and a VA Research Career Scientist. Holding a Ph.D. in Pharmacology and Toxicology, Dr. Patel's extensive research career has focused on caveolin and mitochondrial biology. In this episode, he discusses the critical role of cell membranes and mitochondria in cellular energy and disease, highlighting how his lab developed a non-invasive blood-based assay for mitochondrial function. This innovative assay, developed through the NASA Twin Study, can assess overall energetic health and disease states without invasive biopsies. Dr. Patel also shares his work on the therapeutic potential of the protein caveolin in conditions like heart disease and neurodegeneration (ALS, Alzheimer's, Parkinson's), and how his recent research has expanded to explore the mind-body connection through the transformative work of Dr. Joe Dispenza. We also talk about how his longtime interest in philosophy and religion has influenced his life and career. Please join us for an wonderful conversion between Dr. Panda and Dr. Patel. If you like this episode, please like, comment or follow. Thanks for listening. Guest: Dr. Hemal Patel Professor and Vice-Chair Department of Anesthesiology, UC San Diego School of Medicine VA Research Career Scientist Profile:https://clre.ucsd.edu/faculty/hemal-patel/ Instagram:@hemalpatelphd https://www.instagram.com/@hemalpatelphd Host: Dr. Satchin Panda X (Twitter): @SatchinPanda https://x.com/SatchinPanda Instagram: @satchin.panda https://www.instagram.com/satchin.panda/ Links: Donations: https://panda.salk.edu/giving/ Research: https://www.salk.edu/scientist/satchidananda-panda/ More science: https://mycircadianclock.org/

Welcome to episode 34 of the Performance Around the Clock.  In this episode, host Dr. Satchin Panda, welcomes his esteemed colleague, Dr. Pamela Maher from the Salk Institute for Biological Studies.  Dr. Maher is a rare scientist who has taken drug discovery from basic science findings in cells all the way to compounds being tested in human clinical trials. In this episode, they discuss her journey through research on cell membranes and signaling, leading to her pivotal work on cell death pathways like oxytosis and ferroptosis. The conversation also covers the development of potential therapeutics for aging and Alzheimer's disease, including compounds like J147 and CMS-121, and the exploration of cannabinoids for neuroprotection.  If you like this episode, please like, comment or follow.  Thank you for listening. Guest: Dr. Pamela Maher Research Professor at the Salk Institute Cellular Neurobiology Laboratory Profile: https://www.salk.edu/scientist/pamela-maher/ Host: Dr. Satchin Panda X (Twitter): @SatchinPanda https://x.com/SatchinPanda Instagram: @satchin.panda https://www.instagram.com/satchin.panda/ Links: Donations: https://panda.salk.edu/giving/ Research: https://www.salk.edu/scientist/satchidananda-panda/ More science: https://mycircadianclock.org/

Welcome to the Performance Around the Clock podcast.  In this episode, Dr. Satchin Panda welcomes one of his scientific heroes, Dr. Susan Golden.  Dr. Golden is a pillar in the circadian and cyanobacteria science community and the former director for the Center for Circadian Biology at UC San Diego. She shares her journey from studying gene regulation in cyanobacteria to understanding the circadian clock through this unique organism.  Learn how these ancient blue-green algae were instrumental in the oxygenation of Earth's atmosphere and how tools developed to study cyanobacteria led to groundbreaking discoveries.  Beyond her research, Dr. Golden also made significant contributions to circadian rhythm education, teaching countless undergraduate students over the years.  If you like this episode, please like, comment or subscribe.  Thank you for listening. Guest: Dr. Susan Golden Director, Center for Circadian Biology Chancellor's Associates Chair (III) in Molecular Biology Distinguished Professor X (Twitter): @susanksgolden https://x.com/susanksgolden Profile: UCSD: https://biology.ucsd.edu/research/faculty/sgolden Wikipedia: https://en.wikipedia.org/wiki/Susan_Golden Paper: Circadian orchestration of gene expression in cyanobacteria https://pubmed.ncbi.nlm.nih.gov/7601351/ Thanks to 理philosophia onlineについて for the photo of Dr. Takao Kondo https://www.philosophia.sci.nagoya-u.ac.jp/snapshots/44.html Host: Dr. Satchin Panda X (Twitter): @SatchinPanda https://x.com/SatchinPanda Instagram: @satchin.panda https://www.instagram.com/satchin.panda/ Links: Donations: https://panda.salk.edu/giving/ Research: https://www.salk.edu/scientist/satchidananda-panda/ More science: https://mycircadianclock.org/

In our last episode from the 2024 Gerontology Society of America (GSA) Annual Scientific Meeting in Seattle, we are honored to host Dr. John Newman and Dr. Brianna Stubbs, both experts in ketone metabolism and aging.  Dr. Newman is a geriatrician and researcher at the Buck Institute for Research on Aging and in the Division of Geriatrics at UCSF.  His research focuses on how ketone bodies, small molecules that our bodies make for energy during fasting or exercise, also work as molecular signals to control inflammation and gene expression.  Dr. Brianna Stubbs is an expert in exogenous ketone metabolism and the Director of Translational Science at the Buck Institute for Research on Aging. She's a former competitive rower and two-time world champion, and she completed her PhD in metabolic physiology at the University of Oxford, where she studied the metabolic effects of ketone esters.  Learn all about their work translating ketone research into the field. If you like this episode or podcast, please like, comment or follow. Thank you for listening.    Guests: Dr. John Newman Division of Geriatrics at UCSF Assistant Professor Buck Institute for Research on Aging X (Twitter): @geriscidoc https://x.com/geriscidoc Profile: Division of Geriatrics at UCSF https://profiles.ucsf.edu/john.newman https://medicine.ucsf.edu/people/john-newman Buck Institute for Research on Aging https://www.buckinstitute.org/lab/newman-lab/ Dr. Brianna Stubbs Director of Translational Science at Buck Institute for Research on Aging X (Twitter): @briannastubbs https://x.com/briannastubbs Host: Dr. Satchin Panda X (Twitter): @SatchinPanda https://x.com/SatchinPanda Instagram: @satchin.panda https://www.instagram.com/satchin.panda/ Links: Donations: https://panda.salk.edu/giving/ Research: https://www.salk.edu/scientist/satchidananda-panda/More science: https://mycircadianclock.org/

Coming from the 2024 Gerontology Society of America (GSA) Annual Scientific Meeting in Seattle, we are excited to welcome Dr. Nathan LaBrasseur for the 31st episode of the Performance Around the Clock podcast. Dr. LaBrasseur is the director of the Robert and Arlene Kogod Center on Aging at the Mayo Clinic and an expert on senescence and aging. He's an author of the book "Mayo Clinic on Healthy Aging: An Easy and Comprehensive Guide to Keeping Your Body Young, Your Mind Sharp and Your Spirit Fulfilled" an updated guide on healthy aging. In this episode, learn about the latest in aging and senescence particularly therapeutics for senescent cells - senotherapeutics. Senotherapeutics can be broken down into senolytics which selectively kill senescent cells and senomorphics which suppress senescence-associated secretory phenotype (SASP) to reduce the negative effects of senescence. Thank you for watching. If you like this episode, please like, comment or subscribe. Guest: Dr. Nathan LaBrasseur Director of the Robert and Arlene Kogod Center on Aging @MayoClinic X (Twitter): @NKLeBRASSEUR https://x.com/nklebrasseur Profile: https://www.mayo.edu/research/faculty/lebrasseur-nathan-k-ph-d-m-s/bio-00055041 Mayo Clinic on Healthy Aging: An Easy and Comprehensive Guide to Keeping Your Body Young, Your Mind Sharp and Your Spirit Fulfilled https://www.amazon.com/Mayo-Clinic-Healthy-Aging-Comprehensive/dp/B0BQYKS8ND Host: Dr. Satchin PandaX (Twitter): @SatchinPanda https://x.com/SatchinPanda Instagram: @satchin.panda https://www.instagram.com/satchin.panda/ Links: Donations: https://panda.salk.edu/giving/ Research: https://www.salk.edu/scientist/satchidananda-panda/ More science: https://mycircadianclock.org/

We continue our series from the 2024 Gerontology Society of America (GSA) Annual Scientific Meeting in Seattle.  Episode 30 of the Performance Around the Clock Podcast, features Dr. Courtney Peterson, a leading researcher in the field of intermittent fasting and time-restricted eating (TRE).  Dr. Peterson is an Associate Professor at the University of Alabama at Birmingham where she was notably the first to test early time-restricted eating (eTRE) in humans. Dr. Peterson is the principal investigator of numerous clinical trials on TRE, including the largest randomized controlled trial of intermittent fasting in individuals with type 2 diabetes. Her research combines chronobiology, nutrition, and metabolism and aims to develop dietary interventions to combat cardiometabolic diseases.  Learn all about her research in this episode. If you like this episode, please like, comment or subscribe.  Thank you for listening.    Guest: Dr. Courtney Peterson Associate Professor University of Alabama Birmingham X (Twitter): @CourtneyP_PhD Profile: https://scholars.uab.edu/3393-courtney-peterson  Early Time-Restricted Feeding Improves Insulin Sensitivity, Blood Pressure, and Oxidative Stress Even without Weight Loss in Men with Prediabetes https://pubmed.ncbi.nlm.nih.gov/29754952/ Host: Dr. Satchin Panda X (Twitter): @SatchinPanda https://x.com/SatchinPanda Instagram: @satchin.panda https://www.instagram.com/satchin.panda/ Links: Donations: https://panda.salk.edu/giving/ Research: https://www.salk.edu/scientist/satchidananda-panda/ More science: https://mycircadianclock.org/

Episode 29 of the Performance Around the Clock Podcast is our second episode from the 2024 Gerontology Society of America (GSA) Annual Scientific Meeting in Seattle.  We are privileged to host Dr. Steven Austad who is a leading expert in aging biology. Dr. Austad is a Distinguished Professor and Chair of Biology at the University of Alabama at Birmingham, Director of UAB's Nathan Shock Center of Excellence in the Basic Biology of Aging and Senior Scientific Director of the American Federation for Aging Research (AFAR).  His varied career from large cat training, longevity field work with opposums, calculating the age of greenland sharks, to work with numerous other species gives Dr. Austad a unique view on longevity and aging.  He developed the Longevity Quotient (LQ) which is simplified measure that enables normalized comparisons of various species' longevity.  Learn all about his work on longevity and aging in this episode.  If you like this episode, please like or follow/subscribe.  Thank you for listening. In addition to authoring over 200 scientific articles and more than 150 newspaper columns on science. Dr. Austad has been a recipient of numerous awards such as: Fifth Nathan A. Shock Award Robert W. Kleemeier award Purdue University Outstanding Alumnus Award Irving S. Wright Award of Distinction Fondation IPSEN Longevity Prize Caroline P. and Charles W. Ireland Prize for Scholarly Distinction. He is also a fellow of the Gerontological Society of America (GSA) and the American Association for the Advancement of Science (AAAS). In 2021, he was appointed Protective Life Endowed Chair of Health Aging Research at the University of Alabama at Birmingham. Guest: Dr. Steven Austad's X (formerly Twitter): @StevenAustad https://x.com/StevenAustad UAB Faculty Page https://www.uab.edu/cas/biology/people/faculty/steven-n-austad Books: “Why We Age” https://www.amazon.com/Why-We-Age-Science-Discovering/dp/0471148032/ "Methuselah's Zoo."    https://www.amazon.com/Methuselahs-Zoo-Nature-Living-Healthier/dp/B0CL5D1SY7/ Host: Dr. Satchin Panda X (Twitter): @SatchinPanda https://x.com/SatchinPanda Instagram: @satchin.panda https://www.instagram.com/satchin.panda/ Links: Donations:https://panda.salk.edu/giving/ Research:https://www.salk.edu/scientist/satchidananda-panda/ More science:https://mycircadianclock.org/