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The Most Interesting Thing in AI

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Rating
★★★★★
4.7
from
50 reviews
Categories
Country
United States
This podcast has
23 episodes
Language
English
Explicit
No
Date created
2024/12/03
Latest episode
2026/04/22
Average duration
33 min.
Release period
24 days

Description

A podcast series examining how AI is reshaping our world. Hosted by Nicholas Thompson, each episode features a conversation with a leading thinker who offers a fresh perspective on the far-reaching ethical, economic, and social implications of this technology.

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Podcast episodes

Check latest episodes from The Most Interesting Thing in AI podcast


Data Centers in Space - with Nicholas Thompson and Ariel Ekblaw
2026/04/22
AI needs data centers, and those data centers need energy and cooling. Recently, one proposal has captured the popular imagination: put data centers in space, where there’s ample solar energy and naturally cool surroundings. But things aren’t quite that simple, says space architect Ariel Ekblaw of the Aurelia Institute. On this episode of The Most Interesting Thing in AI, Ekblaw talks with The Atlantic CEO Nicholas Thompson about the possibilities for building structures in space, the innovative designs coming out of the Aurelia Institute, and why data centers in space are a good idea… for certain billionaires.  Produced in collaboration with PwC. (00:00) Introduction (02:22) What is a space architect?  (04:45) How does someone become a space architect? (07:39) How do "space Magna-Tiles" work? (11:00) Why build in space? (12:45) Will we have chatbots in space? (15:00) How space will change robotics (16:56) Why would anyone want to live in space?  (19:55) Will we actually go to space soon?  (20:49) Artificial gravity Learn more about your ad choices. Visit megaphone.fm/adchoices
Season 4 Trailer
2026/04/15
Where does AI go next? And what happens to us? Join The Atlantic’s CEO Nicholas Thompson as he speaks with leaders, developers, philosophers, and more about AI’s impacts, present and future. New episodes every Wednesday, starting April 22.  Produced in collaboration with PwC. Learn more about your ad choices. Visit megaphone.fm/adchoices
The Copyright Wars - with Nicholas Thompson and Bill Gross
2025/11/26
In this episode, The Atlantic’s CEO Nicholas Thompson speaks with serial entrepreneur and Idealab founder Bill Gross about his latest venture, ProRata, a bold attempt to create a fair exchange of value between AI companies and the creators whose work helped train their models. From inventing search advertising to tackling one of AI’s most urgent ethical challenges, Gross explains how innovation and fair market dynamics can align—and how humans are still underestimating the transformative power of AI. (00:00) Introduction (06:32) How Bill invented paid search in the 1990s (13:29) NYT v. OpenAI as the “lightning strike moment” that inspired ProRata (16:16) Solving the “impossible problem” of AI attribution (21:36) ProRata’s plan for revenue sharing between creators and AI companies (24:13) How YouTube shows revenue sharing could make AI companies even stronger (28:20) When there will be a one-person company with a billion-dollar valuation (29:23) AI could be net positive for the climate in as little as five years (33:01) The most interesting way Bill has used AI recently Learn more about your ad choices. Visit megaphone.fm/adchoices
Building Trustworthy AI - with Nicholas Thompson and Navrina Singh
2025/11/19
What happens when AI learns faster than its makers can control? In this episode, Nicholas talks with Navrina Singh, founder and CEO of Credo AI, about how regulation could actually accelerate innovation of more responsible, transparent AI. Together, they dig into how governance can help the U.S. compete with China, prevent bias, and keep trust and transparency at the center of the AI revolution. (00:00) Introduction (04:09) What we learned from Microsoft’s Tay disaster (06:58) Why Navrina started Credo AI (11:12) Managing risk across the AI supply chain (12:43) Preventing bias in customer support chatbots (17:54) Is AI making the world less equal? (19:40) Ethics vs. speed in the AI race with China (21:40) How governance leads to better, faster products (28:04) Why there’s no perfect AI regulation right now (31:14) Preparing for a world where AI governs itself (34:15) The most interesting way Navrina has used AI Learn more about your ad choices. Visit megaphone.fm/adchoices
AI in Flight - with Nicholas Thompson, Tory Bruno and Joe Schurman
2025/11/12
The space race has gone private, and in this new world, efficiency is key. United Launch Alliance CEO Tory Bruno explains how a legacy rocket maker remade itself to compete in an industry full of startups. From load analysis and low-earth-orbit satellite monitoring to rockets with autonomous flight systems, Bruno unpacks what happens when machine learning meets computational fluid dynamics in our atmosphere. Plus, why AI might be critical to landing  a man on Mars—and getting them home alive. (00:00) Introduction (01:38) From backyard rockets to Boeing and Lockheed (Tory Bruno) (03:58) Transforming ULA for a new space race (06:09) The physics of launch: energy, precision, and peril (08:41) Reprogramming flight paths with AI (10:55) The coming age of autonomous and reusable rockets (16:27) When we'll really send humans to Mars—and bring them back (19:36) How AI could help us find, and talk to, alien life (29:20) AI in the space economy (Joe Schurman) (34:16) The $2 trillion future of space (37:51) The most interesting way Joe has used AI Learn more about your ad choices. Visit megaphone.fm/adchoices
Artificial Life - with Nicholas Thompson and Lee Cronin
2025/11/05
How do you digitize the physical world? In this episode, Nick talks with University of Glasgow chemistry professor Lee Cronin, founder of Chemify—a company that is using AI to turn molecules to code s—about his quest to create a programming language for chemistry, what it means to “print” molecules, and how his team is able to discover new drugs and materials through their “chemputer.” He also discusses how the work is offering new insights into the origins of life on Earth and how to identify it on other planets. (00:00) Introduction (01:45) From setting fires to studying life (05:00) Creating a programming language for chemistry (09:20) Designing and “printing” new molecules (10:45) How hype has distorted AI’s promise (14:17) From sand to cells: the origin of life (16:01) Assembly theory and the bridge from nonlife to life (19:15) What it would take for AI to come alive (23:48) The most interesting way Lee has used AI Learn more about your ad choices. Visit megaphone.fm/adchoices
The Future of AI at Work - with Nicholas Thompson and Matt Wood
2025/10/29
What does it take to succeed in the disruptive world of AI? In this episode, Atlantic CEO Nicholas Thompson sits down with Matt Wood, PwC’s Global  and U.S. Commercial Technology and Innovation Officer, to trace his path from medical school and protein folding research to Amazon Web Services and now PwC. They discuss the transformative power of AI; why, when disruptive forces emerge, companies may be better off doubling down on their core identity rather than reinventing themselves; and how the organizations of the future may be reshaped by autonomous agents working alongside humans. (00:00) Introduction (02:16) Matt's path from medicine to machine learning (05:47) The Human Genome Project and the data explosion (09:28) The AI inflection point (11:41) Why AI’s biggest impact will be organizational, not technical (13:30) How companies navigate disruption without losing identity (19:18) The coming flattening of organizations (22:02) Managing teams of humans and agents (25:41) The most interesting way Matt has used AI Learn more about your ad choices. Visit megaphone.fm/adchoices
The AI Athlete - with Nicholas Thompson and Will Ahmed
2025/10/22
Can AI unlock your full potential as an athlete? In this episode, Nicholas speaks with Will Ahmed, founder and CEO of Whoop, about how wearable technology and AI are transforming health, performance, and longevity. From monitoring sleep and recovery to analyzing biomarkers and offering personal health insights, Ahmed shares how Whoop is pushing the boundaries of what’s possible in healthcare in the age of AI.  (00:00) Introduction (02:09) What WHOOP measures and how it works (09:20) What new metrics could reveal about the mind and body (15:25) How AI advances are changing WHOOP (18:16) Balancing personalization with privacy (24:00) Measuring health span and longevity (24:37) When performance and health diverge (27:31) The future of preventative, AI-driven health (30:39) The most interesting way Will has used AI Learn more about your ad choices. Visit megaphone.fm/adchoices
Neuro-Symbolic AI - with Nicholas Thompson and Ohad Elhelo
2025/10/15
In this episode, Atlantic CEO Nicholas Thompson speaks with Ohad Elhelo, co-founder and CEO of AUI, about neuro-symbolic systems. Apollo-1, AUI's neuro-symbolic foundational model, promises both the fluency of generative models and the reliability of symbolic reasoning, an AI method that uses symbols and explicit rules to represent knowledge and perform logical inference. Could this hybrid architecture finally unlock task-oriented AI at scale? (00:00) Introduction (02:57) A rift in the AI community (04:59)  Why neuro-symbolic AI could succeed where chatbots have failed (12:04) How AUI built its model (19:11) How to solve the hallucination problem (25:46) Business use cases for neuro-symbolic AI (30:48) What happens once Apollo One launches (35:03) The most interesting way Ohad has used AI Learn more about your ad choices. Visit megaphone.fm/adchoices
Season 3 Trailer
2025/10/08
A podcast series examining how AI is reshaping our world. Each episode features a conversation with a leading thinker who offers a fresh perspective on the far-reaching ethical, economic, and social implications of this technology. Learn more about your ad choices. Visit megaphone.fm/adchoices
AI Optimism - with Nicholas Thompson and Kevin Kelly
2025/06/18
What happens if we get AI right? In this episode, Nicholas speaks with Wired co-founder Kevin Kelly about AI’s potential to positively impact the future of humanity. Featured Guest: Kevin Kelly, co-founder of Wired Learn more about your ad choices. Visit megaphone.fm/adchoices
Pharma's Future - with Nicholas Thompson, Diogo Rau and Dan Priest
2025/06/11
How is AI shaping the future of healthcare? In this episode, Nicholas speaks with Eli Lilly’s Diogo Rau about how AI is making it easier and faster to find life-saving drugs, and PwC Chief AI Officer Dan Priest about how the technology will transform healthcare experiences for patients in the next decade. Featured Guests: Diogo Rau, Executive Vice President and Chief Information and Digital Officer at Eli Lilly & Dan Priest, Chief AI Officer at PwC Learn more about your ad choices. Visit megaphone.fm/adchoices
Making Music With AI - with Nicholas Thompson and Holly Herndon
2025/06/04
AI is transforming the creative landscape, opening up possibilities for a new generation of artists. In this episode, Nicholas speaks with experimental musician and AI artist Holly Herndon about the intersection of human and machine creativity. Featured Guest: Holly Herndon, co-founder of Spawning Learn more about your ad choices. Visit megaphone.fm/adchoices
Outsourcing Thought - with Nicholas Thompson and Nita Farahany
2025/05/28
AI is reshaping not just what we think but how we think. In this episode, Nicholas speaks with neuroethicist and legal scholar Nita Farahany about AI's impact on human cognition. Featured Guest: Nita Farahany, Robinson O. Everett Distinguished Professor of Law & Philosophy at Duke University and founding director of the Duke Initiative for Science & Society Learn more about your ad choices. Visit megaphone.fm/adchoices
Ethical Machines - with Nicholas Thompson and Audrey Tang
2025/05/21
In the right hands, AI can strengthen human collaboration and civic engagement. In this episode, Nicholas speaks with Taiwanese politician and programmer Audrey Tang about how the technology can be used to enhance democratic structures. Featured Guest: Audrey Tang, Taiwan's Ambassador-at-Large for Cyber Affairs Learn more about your ad choices. Visit megaphone.fm/adchoices

Podcast reviews

Read The Most Interesting Thing in AI podcast reviews


4.7 out of 5
50 reviews
★★★★★
JoelieJoelie 2026/04/17
Not to be missed
The people that are interviewed on the show are each and every one of them someone I need to hear from. Nina Farahany’s podcast was fantastic and very...
★★★★★
NinJoe29 2025/10/16
Superb
Excellent podcast. Great hub of info for current and future AI. Highly recommend!
★★★★★
Emilia Jack 2025/10/08
Intelligent and Informative
Expertly hosted, interesting guests and discussions. Learned a bunch.
★★★★★
Hannah..C22 2024/12/14
Speakers
The first episode was fantastic and one I recommended to friends and colleagues, however the second episode felt very biased. I would love to hear mor...
★★☆☆☆
FrannkyG 2025/06/21
Meh
The notion that LLMs have ethical values is laughable. Sentient word prediction? What a joke. Not worth your time.
★☆☆☆☆
yeheshua 2025/05/23
the topic drives but the show fails
the best episode was the first one - the topic itself is absolutely fascinating and poinent and timely. The show simply bringing up the subject week ...
check all reviews on apple podcasts

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