Advertise on podcast: Peptides and Longevity: Redefining Aging and Transforming Health with Dr. Kent Holtorf

While amyloid and p-tau are widely viewed as the culprits behind Alzheimer's, they are fundamentally antimicrobial peptides that the brain generates to protect itself. On Peptides and Longevity, Dr. Richard Horowitz explains why that moves the question to what they are responding to. He walks through the case report he published this year, in which a patient with 15 years of chronic Lyme symptoms saw an elevated p-tau217 return to the normal range after a nine-week dapsone combination protocol. We also go through his 16-point MSIDS map to track down the root of chronic inflammation. - - - - - About the Guest: Dr. Richard Horowitz is a board-certified internist and medical director of the Hudson Valley Healing Arts Center, where he combines classical and integrative medicine. Over 42 years, he has treated more than 13,000 chronically ill patients from around the world, and he has advised government agencies on tick-borne disease. He is a founding member and past president-elect of ILADS, and past president of ILADEF. He developed the multiple systemic infectious disease syndrome (MSIDS) model, a 16-point map of the sources of chronic inflammation, and he has published on Lyme disease, long COVID, and Alzheimer's biomarkers. He is the author of Why Can't I Get Better?, How Can I Get Better?, and Ending Chronic Illness (Simon & Schuster). He now consults with other physicians on complex cases. Website: https://cangetbetter.com - - - - - About the Host: Dr. Kent Holtorf, MD, is the medical director of Holtorf Medical Group and the founder of Integrative Peptides. He is also a founder and director of the nonprofit National Academy of Hypothyroidism, which exists to provide evidence-based information on the diagnosis and treatment of hypothyroidism to doctors and patients. His clinical focus is the patient nobody has been able to help: tick-borne illness, chronic fatigue syndrome, fibromyalgia, CIRS, MCAS, long COVID, and neurodegenerative disease, alongside hormone optimization and longevity medicine. He works at the mechanism level, and he is candid that much of what he teaches sits ahead of where mainstream guidelines currently are. - - - - - Social Handles: Websites: ⁠⁠⁠⁠https://holtorfmed.com⁠⁠⁠⁠; ⁠⁠⁠⁠https://integrativepeptides.com⁠⁠⁠⁠ Instagram: ⁠⁠⁠⁠https://www.instagram.com/integrativepep⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ ; ⁠⁠⁠https://www.instagram.com/holtorfmedicalgroup⁠⁠⁠⁠ National Academy of Hypothyroidism: ⁠⁠https://nahypothyroidism.org⁠ - - - - - PODCAST Thank you for listening. Please subscribe and share. This podcast is produced by DrTalks.com ⁠⁠https://drtalks.com/channel-growth/

A thyroid hormone does nothing until it gets inside the cell, and the transporter that carries T4 in is one of the first things to slow down when energy runs low. Part 2 of my clinician series on Peptides and Longevity is about that transport step. I explain why T4 uptake drops faster than T3 uptake under stress, what a high reverse T3 tells me, and the other markers I use to spot low tissue thyroid. The second half introduces peptides and bioregulators, followed by questions from the practitioners who attended. - - - - - About the Host: Dr. Kent Holtorf, MD, is the medical director of Holtorf Medical Group and the founder of Integrative Peptides. He is also a founder and director of the nonprofit National Academy of Hypothyroidism, which exists to provide evidence-based information on the diagnosis and treatment of hypothyroidism to doctors and patients. His clinical focus is the patient nobody has been able to help: tick-borne illness, chronic fatigue syndrome, fibromyalgia, CIRS, MCAS, long COVID, and neurodegenerative disease, alongside hormone optimization and longevity medicine. He works at the mechanism level, and he is candid that much of what he teaches sits ahead of where mainstream guidelines currently are. - - - - - Social Handles: Websites: ⁠⁠⁠https://holtorfmed.com⁠⁠⁠; ⁠⁠⁠https://integrativepeptides.com⁠⁠⁠ Instagram: ⁠⁠⁠https://www.instagram.com/integrativepep⁠⁠⁠⁠⁠⁠⁠⁠ ; ⁠⁠https://www.instagram.com/holtorfmedicalgroup⁠⁠⁠ National Academy of Hypothyroidism: ⁠https://nahypothyroidism.org - - - - - PODCAST Thank you for listening. Please subscribe and share. This podcast is produced by DrTalks.com ⁠https://drtalks.com/channel-growth/

Most of what we were taught about reading a thyroid panel assumes a young, healthy patient with no stress, no toxin exposure, and no chronic illness. I have yet to meet that patient in practice. This lecture is the first of three I recorded for practitioners, and it lays the groundwork for everything I teach about thyroid, peptides, and bioregulators. I start with the immune system because, in my experience, it sits underneath most chronic illness and aging. Stress, mold and toxin exposure, chronic infections, and age push the immune system away from TH1 and toward TH2 and TH17. A weak TH1 response makes it harder to clear intracellular infections and senescent cells, and psychological stress is one of the biggest triggers I see. The thymus starts to shrink in adolescence, and I explain why I watch the CD4-to-CD8 ratio as a marker of immune age. Then the thyroid. The pituitary relies mainly on type 2 deiodinase, which keeps converting T4 to T3 under stress. The body's other cells shift toward type 3 deiodinase and make more reverse T3. So the pituitary can have plenty of T3 and turn TSH down while the periphery is short. The pattern I see constantly is a low-normal TSH, a high-normal free T4, a low-normal free T3, and a high-normal reverse T3. I also cover how repeated dieting, insulin resistance, and inflammation affect T4-to-T3 conversion, why I still check basal metabolic rate and reflex relaxation time, and the studies that make me question relying on TSH and antibodies alone in Hashimoto's. - - - - - About the Host: Dr. Kent Holtorf, MD, is the medical director of Holtorf Medical Group and the founder of Integrative Peptides. He is also a founder and director of the nonprofit National Academy of Hypothyroidism, which exists to provide evidence-based information on the diagnosis and treatment of hypothyroidism to doctors and patients. His clinical focus is the patient nobody has been able to help: tick-borne illness, chronic fatigue syndrome, fibromyalgia, CIRS, MCAS, long COVID, and neurodegenerative disease, alongside hormone optimization and longevity medicine. He works at the mechanism level, and he is candid that much of what he teaches sits ahead of where mainstream guidelines currently are. - - - - - Social Handles: Websites: ⁠⁠https://holtorfmed.com⁠⁠; ⁠⁠https://integrativepeptides.com⁠⁠ Instagram: ⁠⁠https://www.instagram.com/integrativepep⁠⁠⁠⁠⁠ ; ⁠https://www.instagram.com/holtorfmedicalgroup⁠⁠ - - - - - PODCAST Thank you for listening. Please subscribe and share. This podcast is produced by DrTalks.com https://drtalks.com/channel-growth/

Most of the patients I see have already been told their thyroid is fine. A TSH in range, a free T4 in range, and a conversation that stops there. My argument in this session is that in chronic illness those two numbers are the least informative part of the panel, because they tell you about signalling and circulating supply rather than about what is getting into the cell and being used. So I go through what I look at instead. Free T3 rather than free T4 alone. The relationship between free T3 and reverse T3, because a rising reverse T3 changes the picture even when everything else reads as acceptable. And clinical signs that are not on the panel at all: basal metabolic rate, body temperature, and the relaxation phase of a reflex, which is old fashioned and, to my eye, still underused. None of this is a replacement for the standard tests. It is what I think has to sit alongside them before you tell a sick patient there is nothing wrong. The second half is about why I pair that with immune modulation. In the chronically ill patient you tend to see the immune system shifted in one direction and stuck, and my view is that treating the thyroid without addressing that shift leaves you fighting the same problem twice. This is where peptides come in, and the mechanical distinction is the part worth holding onto. A hormone goes into the nucleus and changes protein synthesis, which makes it slow to come on and slow to come off. Peptides mostly act at the cell surface and work through a cascade of secondary messengers, so they come on and off faster and tend to have several effects at once rather than a single one. That is why I describe hormones as the blunt instrument and peptides as the finer one, and it is also why I am careful about stacking them without knowing what each is doing. I walk through the classes I use and what they are being studied for: thymic peptides for immune balance, pineal peptides and bioregulators in the longevity and sleep space, nootropic peptides for cognitive and brain injury work, mitochondrial peptides, and the melanocortin family. I go through a lot of published work quickly, and I want to be plain about what that evidence is. A large part of it is animal work, small trials, and research from outside the United States. Several of the compounds I name are not approved by the FDA for the uses discussed, and some are not available as prescribed medicines at all. I share the mechanisms because I think clinicians should know them, not because the case is closed. This session was recorded for a clinical audience and it includes my own interpretation of the literature and my own clinical approach, neither of which is a standard of care. It is not medical advice, no dosing guidance from it should be applied to yourself, and nothing here is a reason to change or stop a prescribed medication. If any of it is relevant to you, take it to the clinician who is actually looking after you. - - - - - About the Host: Dr. Kent Holtorf, MD, is the medical director of Holtorf Medical Group and the founder of Integrative Peptides. He is also a founder and director of the non profit National Academy of Hypothyroidism, which exists to get evidence based information on the diagnosis and treatment of hypothyroidism to doctors and patients. His clinical focus is the patient nobody has been able to help: tick borne illness, chronic fatigue syndrome, fibromyalgia, CIRS, MCAS, long COVID, traumatic brain injury and neurodegenerative disease, alongside hormone optimization and longevity medicine. He works at the mechanism level, and he is candid that much of what he discusses sits ahead of where mainstream guidelines currently are. - - - - - Social Handles: Holtorf Medical Group: holtorfmed.com National Academy of Hypothyroidism: nahypothyroidism.org - - - - - PODCAST Thank you for listening. Please subscribe and share. This podcast is produced by DrTalks.com https://drtalks.com/channel-growth/

I keep coming back to one idea in this talk: the immune system is not a side character in aging and chronic illness—it is closer to the director. I lay out the teeter-totter first: the TH1 and regulatory side against the TH2 and TH17 side, and how the thymus winding down from childhood on quietly shifts that balance until an aged immune phenotype takes over. From there, the dominoes are familiar to anyone who works with complex patients: hypothalamic and pituitary hormone dysfunction, mitochondria slipping into the cell danger response, leaky gut, cognitive fog, and the low-grade inflammation that tracks with how old you actually are on the inside. Then I spend real time on senescent cells, because that is where a lot of the longevity research has landed. These are worn-out cells that should be cleared and instead stick around, secreting the inflammatory signals that show up in the diseases we associate with aging, while falling natural killer function lets them pile up. I connect that to the chronically ill patient, who is often carrying a heavy senescent load from an unresolved infection or autoimmune process, and I make the case for immune-directed peptides and bioregulators, the third-generation oral tools I have been working with, as a way to work on that layer. It runs dense, and that is on purpose. The more you know here, the more you know you do not know. - - - - - About the Host: Dr. Kent Holtorf, MD, has spent most of his career on the patients other clinics send away: tick-borne illness, chronic fatigue syndrome, fibromyalgia, CIRS, mast cell activation, long COVID, and the multi-system cases that never fit one specialty. He is the medical director of Holtorf Medical Group, the founder and medical director of Integrative Peptides, and president and medical director of the National Academy of Hypothyroidism, a nonprofit built around the argument that thyroid diagnosis in the United States has not caught up with its own published literature. He came to peptides as a patient first. Years of chronic Lyme, Babesia, and Bartonella that did not respond to high-dose IV antibiotics ended in heart failure from fibrosis, and it was a course of peptides that turned it around. He has since given close to a hundred CME-approved presentations worldwide, published in peer-reviewed journals, and written Mold Illness: The Peptide Protocol for the Rapid Treatment of CIRS. - - - - - Social Handles: Websites: ⁠https://holtorfmed.com⁠; ⁠https://integrativepeptides.com⁠ Instagram: ⁠https://www.instagram.com/integrativepep⁠⁠ ; https://www.instagram.com/holtorfmedicalgroup⁠ - - - - - PODCAST Thank you for listening. Please subscribe and share. This podcast is produced by DrTalks.com https://drtalks.com/podcast-service/

I did not plan to give this talk. I arrived at the AIMS Symposium, realized how much of the room was aesthetics, and did not have a single slide on the oral skin bioregulators we have been working on for years. So I rebuilt it. What is happening in that room is worth paying attention to, because beauty and functional medicine are being pushed together and nobody has decided yet whether the plastic surgeons, the regenerative doctors, the orthomolecular people or the naturopaths end up owning it. The premise underneath all of it is simple enough. People who feel good on the inside want to look like it on the outside, and the inside is where the instruction actually gets written. So I skipped my usual hour of theory and went to the data. What a peptide is, what a bioregulator is, and why the distinction matters: peptides bind at the cell surface and signal, while bioregulators are two to four amino acids, small enough to enter the nucleus and sit down on the DNA, turning genes of aging down and youthful ones up, one tissue at a time. Then the skin studies. Sirtuin 1 and 6 and collagen synthesis in young and aged cultures, markers of proliferation and repair going one way, caspase-3 and MMP-9 going the other, and a human trial on a placenta derived dermatologic peptide measuring wrinkle depth, elasticity, hydration and pigment across twelve weeks. After that, the parts of the catalogue people ask me about most: the thyroid bioregulators and the separate thyroid axis version that is the one that touches antibodies, the brain and vascular bioregulators, the pancreas work in type 2 diabetes, muscle and grip strength, and the long-running biologic age trials out of Russia that rotate five to seven bioregulators and track telomere length and methylation age. I also tell the story of where all of this came from, which starts with the Soviet military noticing that its cosmonauts, jet pilots and submariners were aging far faster than they should have been. Take the mechanism seriously and the aesthetic result stops being the goal and starts being the receipt. - - - - - About the Host: Dr. Kent Holtorf, MD has spent most of his career on the patients other clinics send away: tick-borne illness, chronic fatigue syndrome, fibromyalgia, CIRS, mast cell activation, long COVID, and the multi-system cases that never fit one specialty. He is the medical director of Holtorf Medical Group, the founder and medical director of Integrative Peptides, and president and medical director of the National Academy of Hypothyroidism, a nonprofit built around the argument that thyroid diagnosis in the United States has not caught up with its own published literature. He came to peptides as a patient first. Years of chronic Lyme, Babesia, and Bartonella that did not respond to high-dose IV antibiotics ended in heart failure from fibrosis, and it was a course of peptides picked up abroad that turned it around. He has since given close to a hundred CME-approved presentations worldwide, published in peer-reviewed journals, sat on editorial boards in endocrinology and specialty medicine, and written Mold Illness: The Peptide Protocol for the Rapid Treatment of CIRS. This talk is the first time he has taken the bioregulator work into aesthetics. - - - - - Social Handles: Website: https://holtorfmed.com https://integrativepeptides.com Instagram: https://www.instagram.com/integrativepep https://www.instagram.com/holtorfmedicalgroup - - - - - PODCAST Thank you for listening. Please subscribe and share. This podcast is produced by DrTalks.com https://drtalks.com/podcast-service/

A head injury does not stay in the head. In this episode of Peptides and Longevity, I share the talk I gave for Boston BioLife on treating traumatic brain injury, post-traumatic stress, and neurodegenerative disease as one connected problem instead of three separate ones. I walk through why the blood-brain barrier and the gut open at the same moment, how the immune system shifts and pulls mitochondria, hormones, and mast cells down with it, and which peptides I reach for first when a patient is not healing. If you have been told a brain injury just needs time, this is the mechanism nobody sat down and explained to you. - - - - -  Kent Holtorf, MD, is the founder and medical director of Holtorf Medical Group. His work focuses on complex endocrine dysfunction, hypothyroidism, chronic fatigue, fibromyalgia, Lyme-related illness, hormone optimization, and integrative approaches for patients with symptoms often unexplained by conventional medicine. He is also associated with Integrative Peptides and the National Academy of Hypothyroidism.  Website:⁠https://drkentholtorf.com/⁠ Instagram: ⁠https://www.instagram.com/holtorfmedicalgroup/⁠ - - - - -  Are you a health practitioner exploring peptide therapies? Learn more at ⁠⁠⁠⁠⁠⁠www.integrativepeptides.com⁠⁠⁠⁠⁠⁠ and use code PODLIFE for practitioner savings. For AI-driven insights and tools to support peptide protocols, visit ⁠⁠⁠⁠⁠⁠www.integrativepeptides.ai⁠⁠⁠⁠⁠⁠ - - - - -  Holtorf Medical Group Website: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://holtorfmed.com/⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Facebook: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://www.facebook.com/holtorfmed/⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Instagram: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ IntegrativePeptides ⁠⁠⁠⁠https://www.instagram.com/integrativepep?igsh=MXNjOHpuM3Fpb21hZA==⁠⁠⁠⁠ Holtorf Medical Group ⁠⁠⁠⁠https://www.instagram.com/holtorfmedicalgroup?igsh=dWhnenZyM3g0ajZk&utm_source=qr⁠⁠⁠⁠ NAHIS ⁠⁠⁠⁠https://www.instagram.com/nahypothyroidism?igsh=NnUwYWtsZWRkaTRx⁠⁠⁠⁠ Kent Holtorf, MD YouTube: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://www.youtube.com/channel/UC0S6Kaa1V9-dfo2sPyZPT6A⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Produced by DrTalks ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://drtalks.com/podcast-service/⁠⁠

Aging may begin in the immune system long before symptoms appear. In this Peptides and Longevity episode, Dr. Kent Holtorf breaks down the science behind peptides, immune balance, inflammation, mitochondrial health, sleep, brain function, and why peptide therapies are being explored as tools to support healing and healthy aging.  - - - - -  Kent Holtorf, MD, is the founder and medical director of Holtorf Medical Group. His work focuses on complex endocrine dysfunction, hypothyroidism, chronic fatigue, fibromyalgia, Lyme-related illness, hormone optimization, and integrative approaches for patients with symptoms often unexplained by conventional medicine. He is also associated with Integrative Peptides and the National Academy of Hypothyroidism.  Website:https://drkentholtorf.com/ Instagram: https://www.instagram.com/holtorfmedicalgroup/ - - - - -  Are you a health practitioner exploring peptide therapies? Learn more at ⁠⁠⁠⁠⁠www.integrativepeptides.com⁠⁠⁠⁠⁠ and use code PODLIFE for practitioner savings. For AI-driven insights and tools to support peptide protocols, visit ⁠⁠⁠⁠⁠www.integrativepeptides.ai⁠⁠⁠⁠⁠ - - - - -  Holtorf Medical Group Website: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://holtorfmed.com/⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Facebook: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://www.facebook.com/holtorfmed/⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Instagram: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ IntegrativePeptides ⁠⁠⁠https://www.instagram.com/integrativepep?igsh=MXNjOHpuM3Fpb21hZA==⁠⁠⁠ Holtorf Medical Group ⁠⁠⁠https://www.instagram.com/holtorfmedicalgroup?igsh=dWhnenZyM3g0ajZk&utm_source=qr⁠⁠⁠ NAHIS ⁠⁠⁠https://www.instagram.com/nahypothyroidism?igsh=NnUwYWtsZWRkaTRx⁠⁠⁠ Kent Holtorf, MD YouTube: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://www.youtube.com/channel/UC0S6Kaa1V9-dfo2sPyZPT6A⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Produced by DrTalks ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://drtalks.com/podcast-service/⁠

Fasting isn’t just willpower, it’s a cellular switch. In this Peptides and Longevity episode, nutrition professional Renee Fitton breaks down how fasting mimicking supports deep cellular cleanup, metabolic markers, cravings, and longevity pathways—without the struggle of a traditional water fast. - - - - -  Renee Fitton, MS, RD is a longevity-focused registered dietitian and Director of Education for L-Nutra and ProLon. She trained under Dr. Valter Longo through USC’s Longevity Master’s Program and additional research training in Italy, specializing in fasting and fasting-mimicking nutrition science. Her work centers on helping individuals understand how targeted fasting protocols support cellular health, metabolic balance, and sustainable lifestyle change through science-driven nutrition strategies. Website:https://fittonnutrition.com/ Instagram: https://www.instagram.com/fittonnutrition - - - - -  Are you a health practitioner exploring peptide therapies? Learn more at ⁠⁠⁠⁠www.integrativepeptides.com⁠⁠⁠⁠ and use code PODLIFE for practitioner savings. For AI-driven insights and tools to support peptide protocols, visit ⁠⁠⁠⁠www.integrativepeptides.ai⁠⁠⁠⁠ - - - - -  Holtorf Medical Group Website: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://holtorfmed.com/⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Facebook: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://www.facebook.com/holtorfmed/⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Instagram: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ IntegrativePeptides ⁠⁠https://www.instagram.com/integrativepep?igsh=MXNjOHpuM3Fpb21hZA==⁠⁠ Holtorf Medical Group ⁠⁠https://www.instagram.com/holtorfmedicalgroup?igsh=dWhnenZyM3g0ajZk&utm_source=qr⁠⁠ NAHIS ⁠⁠https://www.instagram.com/nahypothyroidism?igsh=NnUwYWtsZWRkaTRx⁠⁠ Kent Holtorf, MD YouTube: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://www.youtube.com/channel/UC0S6Kaa1V9-dfo2sPyZPT6A⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Produced by DrTalks ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://drtalks.com/podcast-service/⁠

What if weight loss isn’t about willpower, but restoring what your body lost along the way? In this episode of Peptides and Longevity, Dave Knapp shares his journey through obesity, type 2 diabetes, GLP-1 therapy, sobriety, and faith, revealing how peptides, lifestyle change, and spiritual surrender reshaped his health and purpose. - - - - -  Dave Knapp is a podcaster and founder of On The Pen, an obesity medicine news platform focused on educating patients about metabolic health, GLP-1 therapies, and emerging peptide science. After struggling with lifelong obesity and type 2 diabetes, Dave transformed his health through research, lifestyle change, and integrative approaches combining medication, supplementation, and faith. Through his platform, he helps individuals better understand obesity as a complex metabolic condition while encouraging sustainable health habits, personal responsibility, and long-term wellness. Website: https://onthepen.com Instagram:https://www.instagram.com/onthepen.official/ - - - - -  Are you a health practitioner exploring peptide therapies? Learn more at ⁠⁠⁠www.integrativepeptides.com⁠⁠⁠ and use code PODLIFE for practitioner savings. For AI-driven insights and tools to support peptide protocols, visit ⁠⁠⁠www.integrativepeptides.ai⁠⁠⁠ - - - - -  Holtorf Medical Group Website: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://holtorfmed.com/⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Facebook: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://www.facebook.com/holtorfmed/⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Instagram: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ IntegrativePeptides ⁠https://www.instagram.com/integrativepep?igsh=MXNjOHpuM3Fpb21hZA==⁠ Holtorf Medical Group ⁠https://www.instagram.com/holtorfmedicalgroup?igsh=dWhnenZyM3g0ajZk&utm_source=qr⁠ NAHIS ⁠https://www.instagram.com/nahypothyroidism?igsh=NnUwYWtsZWRkaTRx⁠ Kent Holtorf, MD YouTube: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://www.youtube.com/channel/UC0S6Kaa1V9-dfo2sPyZPT6A⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Produced by DrTalks ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://drtalks.com/podcast-service/⁠

Independent pharmacies are filling prescriptions at a loss, and most people have no idea. In this episode of the Peptides and Longevity Podcast, Dr. Lisa Faast breaks down why margins are getting crushed, what clinicians miss about business, and how pharmacy owners can build real stability without losing the heart of patient care. - - - - -  Dr. Lisa Faast, PharmD is a pharmacist with over two decades of experience and an independent pharmacy owner. She is the founder of DiversifyRx, where she helps independent pharmacy owners strengthen their businesses through practical strategy across financials, operations, marketing, and team leadership, so they can survive and thrive in a rapidly changing healthcare landscape. With deep experience in compounding, hormones, functional medicine, and the evolving peptide space, Dr. Faast brings a rare mix of clinical insight and real-world business leadership. She’s also a serial entrepreneur on a mission to help pharmacies stay open, serve their communities, and build sustainable profitability. Website: https://drlisafaast.com/ Instagram: https://www.instagram.com/drlisafaast/ LinkedIn: https://www.linkedin.com/in/dr-lisa-faast-pharmd-the-pharmacy-badass-b03a60318/ - - - - -  Are you a health practitioner exploring peptide therapies? Learn more at ⁠⁠www.integrativepeptides.com⁠⁠ and use code PODLIFE for practitioner savings. For AI-driven insights and tools to support peptide protocols, visit ⁠⁠www.integrativepeptides.ai⁠⁠ - - - - -  Holtorf Medical Group Website: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://holtorfmed.com/⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Facebook: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://www.facebook.com/holtorfmed/⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Instagram: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠IntegrativePeptideshttps://www.instagram.com/integrativepep?igsh=MXNjOHpuM3Fpb21hZA== Holtorf Medical Grouphttps://www.instagram.com/holtorfmedicalgroup?igsh=dWhnenZyM3g0ajZk&utm_source=qr NAHIShttps://www.instagram.com/nahypothyroidism?igsh=NnUwYWtsZWRkaTRx Kent Holtorf, MD YouTube: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://www.youtube.com/channel/UC0S6Kaa1V9-dfo2sPyZPT6A⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Produced by DrTalks ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://drtalks.com/podcast-service/⁠

What if healthcare practitioners could serve people more freely while preserving patient choice? In this episode of Peptides and Longevity, Michael Blake, founder of Forgotten Formula, explains Private Membership Associations (PMAs), how member-based models function, and why some clinicians are exploring constitutional frameworks to support integrative, root-cause care. - - - - -  Michael Blake is the founder of Forgotten Formula and a leading voice in root-cause healing for chronic illness, autoimmunity, and cancer-related conditions. His work focuses on tracing disease back to early-life microbiome disruption, toxic exposure, infections, and nutrient depletion. Through a systems-based approach that integrates diagnostics, detoxification, nutrient restoration, and mind–body–spirit healing, Michael Blake helps practitioners and patients restore the conditions the body needs to heal itself. Website: https://www.forgottenformula.com/ LinkedIn: https://www.linkedin.com/in/michael-blake-742a8619b - - - - -  Are you a health practitioner exploring peptide therapies? Learn more at ⁠www.integrativepeptides.com⁠ and use code PODLIFE for practitioner savings. For AI-driven insights and tools to support peptide protocols, visit ⁠www.integrativepeptides.ai⁠ - - - - -  Holtorf Medical Group Website: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://holtorfmed.com/⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Facebook: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://www.facebook.com/holtorfmed/⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Instagram: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://www.instagram.com/holtorfmedicalgroup/⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Kent Holtorf, MD YouTube: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://www.youtube.com/channel/UC0S6Kaa1V9-dfo2sPyZPT6A⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Produced by DrTalks ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://drtalks.com/podcast-service/⁠

Healing often stalls when care relies on guesswork instead of clarity. In this episode of Peptides and Longevity, Debi Bryk of MaxGen Labs explains how genetic testing provides a lifelong blueprint for personalized nutrition, lifestyle, and supplementation, helping practitioners and individuals move from trial and error to targeted healing. - - - - -  Debi Bryk, NC, BCHN, is a board-certified holistic nutritionist specializing in functional genomics, autoimmune nutrition, and personalized lifestyle medicine. Inspired by helping her husband achieve long-term remission from ulcerative colitis without medication, she dedicated her career to guiding individuals with complex chronic conditions toward root-cause healing. Through her work with MaxGen Labs, Debi helps practitioners and individuals use genetic testing to create personalized health strategies based on DNA-driven insights rather than trial-and-error approaches. Website: https://www.maxgenlabs.com Instagram: https://www.instagram.com/debibryk/ LinkedIn: https://www.linkedin.com/in/debi-bryk-nc-bchn-370971b6/ - - - - -  Are you a health practitioner exploring peptide therapies?Learn more at www.integrativepeptides.comand use code PODLIFE for practitioner savings. For AI-driven insights and tools to support peptide protocols, visit www.integrativepeptides.ai - - - - -  Holtorf Medical Group Website: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://holtorfmed.com/⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Facebook: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://www.facebook.com/holtorfmed/⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Instagram: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://www.instagram.com/holtorfmedicalgroup/⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Kent Holtorf, MD YouTube: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://www.youtube.com/channel/UC0S6Kaa1V9-dfo2sPyZPT6A⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Produced by DrTalks ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://drtalks.com/podcast-service/⁠

He was preparing to lose his bladder after a cancer diagnosis… until his second surgery revealed something no one expected. In this episode of Peptides and Longevity, Jon Vengochea shares how personalized, multi-system care alongside conventional treatment transformed his strength, outlook, and recovery journey. - - - - -  Jon Vengochea is a patient at Holtorf Medical Group who shares his personal experience navigating a bladder cancer diagnosis and recovery journey. After facing limited treatment options and significant physical decline, Jon pursued personalized integrative care alongside conventional medical treatment focused on immune function, metabolic health, and whole-body support. Through his story, Jon offers a powerful patient perspective on resilience, faith, informed decision-making, and the importance of becoming an active participant in one’s healthcare journey. - - - - -  Holtorf Medical Group Website: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://holtorfmed.com/⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Facebook: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://www.facebook.com/holtorfmed/⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Instagram: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://www.instagram.com/holtorfmedicalgroup/⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Kent Holtorf, MD YouTube: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://www.youtube.com/channel/UC0S6Kaa1V9-dfo2sPyZPT6A⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Produced by DrTalks ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://drtalks.com/podcast-service/⁠

In this episode of Peptides and Longevity, Michael McNeal sits down with Melanie Murphy Richter to break down how the ProLon 5-Day Fasting Mimicking Diet is designed to keep you just below key nutrient-sensing pathways so you can access autophagy, support gut balance, and reduce cravings while still eating real food. Melanie Murphy Richter, MS, RDN, is a registered dietitian nutritionist with a background in healthcare PR and a master’s degree in health span and longevity. She runs a private practice focused on gut-centered care for a wide range of conditions, including autoimmune concerns, anxiety, and depression. She is also the Director of Communications at L-Nutra, a longevity science company behind the ProLon 5-Day Fasting Mimicking Diet. Having studied under Valter Longo and completed numerous ProLon cycles herself, Melanie blends clinical insight with practical experience to help people understand fasting science in a way they can actually follow. Website: https://melaniemurphyrd.com/ Instagram: https://www.instagram.com/healthnmellness/ LinkedIn: https://www.linkedin.com/in/melaniegmurphy/ Holtorf Medical Group Website: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://holtorfmed.com/⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Facebook: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://www.facebook.com/holtorfmed/⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Instagram: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://www.instagram.com/holtorfmedicalgroup/⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Kent Holtorf, MD YouTube: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://www.youtube.com/channel/UC0S6Kaa1V9-dfo2sPyZPT6A⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Produced by DrTalks ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://drtalks.com/podcast-service/⁠