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More tools. New evidence. Tough decisions. With the 2026 AHA/ACC pulmonary embolism (PE) guidelines as a backdrop, when is anticoagulation enough, and when is it time to reach for advanced therapy? Behnood Bikdeli, Jane Leopold, Lisa Moores, and Suresh Vedantham return to take on the treatment questions that follow risk assessment. From fibrinolysis and mechanical thrombectomy to extracorporeal membrane oxygenation (ECMO), the panel weighs what the trials tell us, where uncertainty remains, and what matters at the bedside. Two patient cases put bleeding risk, clot anatomy, clinical trajectory, resources, and patient preferences into the mix. Episode chapters 00:00 Welcome and the Advanced PE Therapy Toolkit 03:06 Fibrinolysis and Thrombectomy: What the Trials Show 11:25 ECMO and Immediate Priorities in High-Risk PE 16:55 Choosing an Intervention: Bleeding Risk, Anatomy, and Resources 20:09 Case Discussions: Anticoagulation Alone or Advanced Therapy? 27:31 Practical Takeaways Thank you to our sponsor, Penumbra, for their generous support of this podcast episode. All content was independently developed by Vasculearn Network and the expert panel. Missed the first conversation? Check out Part 1: PE Risk Stratification to explore the new framework and how to spot patients who may be heading toward trouble.

The blood pressure looks reassuring, but is it telling the whole story? In acute pulmonary embolism (PE), the next few hours can matter as much as the first set of vital signs. Behnood Bikdeli joins experts Jane Leopold, Lisa Moores, and Suresh Vedantham to unpack the 2026 AHA/ACC PE guidelines and put the new risk-stratification framework to work. With two patient cases and practical bedside insights, the panel explores who needs a closer watch, when to mobilize a response team, and how to stay ahead of a patient who may be heading in the wrong direction. Episode chapters 00:00 The New PE Risk-Stratification Framework 06:21 Assessing Risk: Vital Signs, Biomarkers, Imaging, and Scores 11:22 Turning Risk Assessment Into Action: PERT, Monitoring, and Preparedness 18:47 Timing, Resources, and Transfer Decisions 21:59 Case 1: A Stable Presentation With Signs of RV Strain 27:32 Case 2: Transient Hypotension, Closer Monitoring, and Acute-on-Chronic Clues Thank you to our sponsor, Penumbra, for their generous support of this podcast episode. All content was independently developed by Vasculearn Network and the expert panel. What comes after risk assessment? Check out Part 2, where the panel weighs the evidence behind advanced therapies and tackles when—and how—to intervene.

GLP-1s are transforming the treatment of diabetes and obesity, but could their benefits extend to venous thromboembolism (VTE)? And what should clinicians tell patients with a history of VTE? Join host Julia Sandrin Gauer and experts Christian Ruff and Rushad Patell as they discuss: • What current evidence suggests about GLP-1 therapies and VTE risk • The limitations of existing clinical trial and observational data • Whether GLP-1 and multi-incretin therapies may have different effects • What these findings mean for clinical practice, and the questions that remain Tune in now to this special collaboration between the ISTH Pulse Podcast and Vasculearn Network's Clot, Clot, Who's There?, for this timely conversation!

Your patient is bleeding or needs urgent surgery, but no one knows when the last DOAC dose was taken. Is there still enough factor Xa inhibitor on board to change what happens next? Join experts Alex Spyropoulos, Christopher Baugh, and Deborah Siegal as they discuss: • Why stabilization must come before laboratory confirmation • The limitations of routine coagulation tests • How to interpret drug-specific and heparin-calibrated anti-Xa assays • Practical pathways for major bleeding and urgent surgery • The future of rapid point-of-care testing Tune in now and subscribe to Clot, Clot, Who's There? for more expert conversations in thrombosis, hemostasis, and vascular medicine. 00:00: Assessing Residual Factor Xa Activity 03:41: Stabilize First, Test Second 08:56: Lab Testing: Options and Limitations 18:20: Major Bleeding vs. Urgent Surgery 21:54: The Future of Point-of-Care Testing Thank you to our sponsor, VarmX, for their generous support of this podcast episode.  Check out the companion learning course, No Time To Wait: Urgent Situations in Patients on Factor Xa Inhibitors, here.

Factor Xa inhibitors have transformed anticoagulation, but urgent bleeding or surgery may require decisions before clinicians know when the last dose was taken or how much anticoagulant activity remains. Join experts Alex Spyropoulos, Eduardo Ramacciotti, and Preston Hewgley as they discuss: • Why residual factor Xa inhibitor activity matters in urgent care • How an unknown last dose complicates clinical decisions • Why bleeding risk persists despite DOAC advantages over warfarin • How to balance bleeding, thrombosis, and surgical urgency Tune in now and subscribe to Clot, Clot, Who's There? for more expert conversations in thrombosis, hemostasis, and vascular medicine.  00:00: Residual Factor Xa Activity: Why It Matters 01:38: Unknown Last Doses and Urgent Decisions 09:47: Major Bleeding and Urgent Surgery 14:03: Reversal, Treatment Delays, and Outcomes Thank you to our sponsor, VarmX, for their generous support of this podcast episode.  Check out the companion learning course, No Time To Wait: Urgent Surgery in Patients on Factor Xa Inhibitors, here.

The COBRRA Trial and the Questions that Remain Clinicians have long relied on indirect comparisons when choosing between direct oral anticoagulants (DOACs) for VTE. The COBRRA trial changed that. Join experts Behnood Bikdeli, Lana Castellucci, and David Jiménez as they discuss: • The landmark COBRRA trial and its implications for VTE treatment • How bleeding risk, adherence, and patient preferences influence DOAC selection • When alternatives to apixaban may still be preferred • The challenges of conducting head-to-head anticoagulation trials • Global barriers to DOAC access and the next unanswered questions in the field Tune in now and subscribe to Clot, Clot, Who's There? for more expert conversations bridging science, practice, and global perspectives in thrombosis, hemostasis, and vascular medicine.   00:00: Introduction to COBRRA and the First Head-to-Head DOAC Comparison 03:58: Apixaban vs. Rivaroxaban: Key Findings and Clinical Implications 09:45: Adherence, Special Populations, and Choosing the Right DOAC 14:18: Why Did It Take So Long? Designing and Conducting the COBRRA Trial 19:05: Global Access, Reimbursement Challenges, and Real-World Use of DOACs 23:12: The Next Frontier: COBRRA-AF and Remaining Research Questions

When a young, otherwise healthy patient presents with an upper extremity DVT, venous thoracic outlet syndrome should be high on the differential—but the diagnosis is often delayed or missed. Join experts JoMarie Monzon, MSN, FNP-BC and Drs. Donna Bahroloomi, Ali Azizzadeh, and Vincent Jongkind as they discuss: Why venous thoracic outlet syndrome is frequently mistaken for musculoskeletal injury Diagnostic challenges and the role of imaging Current approaches to thrombolysis, decompression, venous reconstruction, and anticoagulation Tune in now and subscribe to Clot, Clot, Who's There? for more expert conversations bridging science, practice, and global perspectives in thrombosis, hemostasis, and vascular medicine. 00:00: Introduction to Venous Thoracic Outlet Syndrome (VTOS) 05:37: Diagnosing VTOS & Understanding the Different Subtypes 10:26: Thrombolysis, Anticoagulation, and Timing of Decompression 14:45: Surgical Approaches, Vein Reconstruction, and Long-Term Outcomes 22:20: Postoperative Anticoagulation Strategies 24:28: Key Clinical Takeaways

In urgent, high-stakes situations—like major bleeding or emergency surgery—how should clinicians assess coagulation in patients on factor Xa inhibitors? And more importantly, are we focusing on the right signal? Join global experts as they explore: Why traditional assays (PT/aPTT, anti-Xa) often fall short in critical decision-making The role of functional testing in assessing true hemostatic potential How VMX-C001, a novel bypassing agent, challenges conventional approaches to reversal and monitoring Be sure to read the VMX-C001 study discussed in the episode: https://www.rpthjournal.org/article/S2475-0379(26)00033-6/fulltext?dgcid=raven_jbs_etoc_email Tune in now and subscribe to Clot, Clot, Who's There? for more expert conversations bridging science, practice, and global perspectives in thrombosis, hemostasis, and vascular medicine. Chapters 00:00 Introduction & Clinical Challenge 02:54 Assessing Factor Xa Inhibitors in Urgent/Emergent Situations 05:29 Why Standard Assays Fall Short 09:38 Functional Testing: dPT & dRVVT 12:35 VMX-C001 & Future Directions This episode was made possible through generous support from VarmX.

Surviving a stroke is only the beginning. Preventing the next one is where the real clinical challenge lies—and for patients with non-cardioembolic stroke, the existing toolkit has long fallen short. Join Drs. Geoff Barnes, Mike Sharma, and Valeria Caso as they explore: Stroke subtypes, recurrence risk, and the unique challenges of non-cardioembolic stroke and ESUS Why current treatment options have fallen short—and what may be next The advent of Factor XI inhibitors and what emerging data may mean for the future of secondary prevention Tune in now and subscribe to Clot, Clot, Who's There? for more expert conversations bridging science, practice, and global perspectives in thrombosis, hemostasis, and vascular medicine. 00:00: Introduction & Stroke Subtypes 03:59: Recurrence Risk & Key Risk Factors 07:24: Current Treatment Strategies 10:54: ESUS & Limits of Anticoagulation 14:19: Moving Beyond Aspirin 16:26: Factor XI Inhibitors: Data & Future Directions This episode was made possible through generous support from Bayer.

When it comes to antithrombotic therapy in coronary artery disease, the central question is no longer "What should everyone get?" It's "What's right for this patient?" In this episode, Drs. Heather Johnson, Ty Gluckman, and Davide Cappodano explore the modern balance between managing clotting and bleeding risk in patients on antiplatelets and anticoagulants. From the evolving role of aspirin and P2Y12 monotherapy to dual pathway inhibition and the management of CAD with atrial fibrillation, the conversation highlights a clear shift: less one-size-fits-all medicine, more individualized—and shared—decision-making. Tune in now and subscribe to Clot, Clot, Who's There? for more expert conversations bridging science, practice, and global perspectives in thrombosis, hemostasis, and vascular medicine.   00:00 – Welcome & Introduction 03:57 – Is Aspirin Still King? 10:26 – Shorter DAPT, Earlier Monotherapy 14:09 – When More Is More: the COMPASS regimen 17:49 – When Less Is More: CAD + AF

In this episode of Clot, Clot, Who's There? Drs. Christian Ruff (USA) and Giulio Francesco Romiti (Italy) chat about long-term anticoagulation management after successful atrial fibrillation ablation. They explore why stroke risk may persist despite rhythm control, examine emerging evidence from the ALONE-AF and OCEAN trials, and consider how patient selection and shared decision-making should inform post-ablation care. Tune in now and subscribe to Clot, Clot, Who's There? for more expert conversations bridging science, practice, and global perspectives in thrombosis, hemostasis, and vascular medicine. 00:00 Welcome & Introductions 01:12 Why Stroke Risk Persists After AF Ablation 04:19 The Anticoagulation Dilemma: Guidelines, Risk & Patient Priorities 09:45 New Evidence After Ablation: ALONE-AF & OCEAN 27:12 Key Takeaways, Shared Decision-Making & What's Next

In this episode of Clot Clot Who's There, Aviva Schwartz, Director of Education at Vasculearn Network, speaks with Professor Gregory Lip about key anticoagulation and atrial fibrillation data from 2025 and what lies ahead in 2026. The discussion spans post–AF ablation management, holistic AF care, and emerging factor XI inhibitors shaping the future of thrombosis management. Tune in now and subscribe to Clot, Clot, Who's There? for more expert conversations bridging science, practice, and global perspectives in thrombosis, hemostasis, and vascular medicine.   Chapters: 00:00 Welcome and Introduction 01:59 2025 Trial Highlights: Anticoagulation in Stable CAD and AF Ablation 07:27 High-Risk AF and Holistic Care 10:10 What's Coming in 2026: Factor XI Inhibitors and Upcoming Trials 11:51 Guidelines vs. Real-World Practice

Host Dr. Alex Spyropoulos is joined by global experts Drs. James Douketis and Marc Samama for a focused, practical discussion on perioperative anticoagulation management in nonurgent procedures. Together, they clarify: When and how to safely interrupt warfarin and direct oral anticoagulants Why heparin bridging is now rarely needed How procedural bleeding risk and pharmacokinetics inform decision-making The episode reviews evidence from key clinical trials, outlines when anticoagulation can safely be continued for minimal-bleed-risk procedures, and explores future directions—including the potential role of Factor XI inhibitors in the perioperative setting. Don't miss this concise, guideline-driven conversation for clinicians managing anticoagulated patients or working within perioperative care teams. Tune in now and subscribe to Clot, Clot, Who's There? for more expert conversations bridging science, practice, and global perspectives in thrombosis, hemostasis, and vascular medicine.   00:00 – Welcome & Introductions 02:34 – Assessing Thrombotic vs. Bleeding Risk 08:56 – Warfarin Interruption & Bridging: What Changed? 16:39 – DOAC Management 23:34 – Procedure Playbook for Low Bleed Risk 29:29 – Future Directions: Factor XIs and Beyond

Host Tara Lech is joined by Drs. Scott Woller and Virginia Silvari for a thoughtful conversation on anticoagulation stewardship: what it is, why it matters, and how it can help patients who need antithrombotic therapy. They share examples from their own practice, talk through common challenges, and offer simple steps for improving care across settings. Topics: What makes anticoagulation stewardship different from traditional management How to choose the right anticoagulant for each patient Practical system-level steps to support safe prescribing Lessons from U.S. and European practices Tips for reassessing therapy and managing periprocedural care Tune in now and subscribe to Clot, Clot, Who's There? for more expert conversations bridging science, practice, and global perspectives in thrombosis, hemostasis, and vascular medicine.   00:00 Welcome & Setting the Stage 02:01 What "Antithrombotic Stewardship" Really Means 05:49 Choosing the Right Agent for the Right Patient 13:39 Reassessment, Follow-Up, & Real-World Impact 22:50 Perioperative Management & Building a Stewardship Culture

Join host Christian Weber, MD (LMU Munich) with vascular biology experts Kimberly Martinod, PhD (University of Rochester) and Konstantin Stark, MD (LMU Munich) as they explore the evolving science of immunothrombosis and thromboinflammation—concepts that rose to prominence during COVID-19 but reach far beyond infectious disease. Learn about: How thrombotic and inflammatory mechanisms impact cardiovascular disease, sepsis, and beyond Emerging biomarkers and therapies with the potential to improve patient outcomes The critical role of scientist–clinician collaboration in translating discoveries into care For cardiologists, hematologists, critical care specialists—or anyone curious about immunity, clotting, and inflammation—this conversation provides both foundational insight and a forward-looking perspective.  Tune in now and subscribe to Clot, Clot, Who's There? for more expert conversations bridging science, practice, and global perspectives in thrombosis, hemostasis, and vascular medicine. 00:00 Welcome and Introductions 01:38 Immunothrombosis vs Thromboinflammation 04:00 How Cells & Molecules Interact 10:20 Clinical Impacts Across Diseases 13:29 Biomarkers & Translational Gaps 17:14 Emerging Therapies 22:04 Key Takeaways & Future Directions