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This Week In Startups is made possible by: LinkedIn Jobs - linkedIn.com/twist Grasshopper Bank - grasshopper.bank/twist Notion - notion.com Today’s show: This week, SpaceX announced that it was partnering with AI coding startup Cursor on new AI models. xAI’s parent company is bringing compute, while Cursor brings developer market share and recent successes, training its own coding models. The deal, while interesting, comes with a steep price tag. SpaceX will pay Cursor $10 billion for their shared work, with an option to buy the entire company for $60 billion later this year. After poking our way through the deal, Chris Zacharia and Brian McRindle of Bitstarter joined Lon and Alex. Bitstarter is a ‘Kickstarter for Bittensor,’ helping founders get their subnet up and running without tripping over their shoelaces. The Bitstarter crew also broke some news on the show, telling TWIST that they have a new accelerator-ish program kicking off. Next, Ning Ren from Trajectory RL joined the program to explain how Bittensor subnet 11 is using decentralized competitions to design and release better skills. Skills — markdown files with words — have become a critical building tool in the agentic era; how Trajectory will monetize is an open, interesting question. Timestamps: 2:27 Plaud: If your work depends on conversations — interviews, meetings, calls — you need a Plaud NotePin. You can check it out at https://Plaud.ai/twist and use code TWIST for 10% off! 4:07 SpaceX/ xAI "partners" with Cursor! 9:35 Will the Cursor deal help pump a future SpaceX IPO? 9:57 LinkedIn Jobs - Hire right, the first time. Post your first job and get $100 off towards your job post at https://LinkedIn.com/twist. 12:14 How AI coding models like Cursor help xAI grow recursively. 17:24 Chris Zacharia and Brian McRindle of Bitstarter join the show. 20:23 Grasshopper Bank: Time is money. Don't waste either. Go to https://grasshopper.bank/twist and get an exclusive $500 cash bonus just for opening an account. 29:59 Notion - Notion brings all your notes, docs, and projects into one connected space that just works with AI built right in. Try Notion, with Notion Agent, at https://www.notion.com/twist 33:03 How Bittensor subnets monetize and how it compares to VC funds. 37:04 Is Bittensor hard-capped at 128 subnets? 42:37 Bittensor's biggest weakness. 46:10 Ning Ren of TrajectoryRL joins the show. 47:34 Skills now need entire agents just to write them! 48:26 Back up… What are skills? 1:07:38 Amazon and Anthropic's 5 BILLION deal 1:08:48 Google has 2 new chips! 1:09:50 Apple CEO, Tim is COOKED! John Ternus is in! 1:11:37 Alex is bullish on MacBook Neo! Subscribe to the TWiST500 newsletter: https://ticker.thisweekinstartups.com Check out the TWIST500: https://www.twist500.com Subscribe to This Week in Startups on Apple: https://rb.gy/v19fcp Follow Lon: X: https://x.com/lons Follow Alex: X: https://x.com/alex LinkedIn: ⁠https://www.linkedin.com/in/alexwilhelm Follow Jason: X: https://twitter.com/Jason LinkedIn: https://www.linkedin.com/in/jasoncalacanis Check out all our partner offers: https://partners.launch.co/ Great TWIST interviews: Will Guidara, Eoghan McCabe, Steve Huffman, Brian Chesky, Bob Moesta, Aaron Levie, Sophia Amoruso, Reid Hoffman, Frank Slootman, Billy McFarland Check out Jason’s suite of newsletters: https://substack.com/@calacanis Follow TWiST: Twitter: https://twitter.com/TWiStartups YouTube: https://www.youtube.com/thisweekin Instagram: https://www.instagram.com/thisweekinstartups TikTok: https://www.tiktok.com/@thisweekinstartups Substack: https://twistartups.substack.com

This Week In Startups is made possible by: Quo - https://quo.com/TWiST Vanta - https://vanta.com/twist Pilot - https://pilot.com/twist Plaud - https://Plaud.ai/twist Today’s show: *Eragon CEO Josh Sirota believes that you should “own your intelligence.” He demos a live enterprise AI operating system connecting email, Slack, calendar, and financial data into a single agentic layer that’s pre-trained to understand any business inside and out. PLUS we’ve got IONA Drones founder Etienne Louvet, a first look at Moonshot’s Kimi K2.6, and a brand new Off Duty with JCal and Lon. FULL SHOW NOTES ON NOTION: https://thisweekinstartups-docket.notion.site/TWiST-2278-SHOW-NOTES-34872ca918e380bd9c71e684ce2db7c9?source=copy_link Guests : Eragon: https://eragon.ai Josh Sirota on X: https://x.com/joshua_sirota IONA: https://ionadrones.com/ Etienne Louvet on X: https://x.com/etienneldva Relevant Links Eragon Seed Round coverage: https://techcrunch.com/2026/03/18/this-startup-wants-to-make-enterprise-software-look-more-like-a-prompt/ Neurometric: https://www.neurometric.ai/ Ollama model: https://ollama.com/ Orange Slice: https://www.orangeslice.ai/ Corgi Insurance: https://www.corgi.insure/ Slash Financial: https://www.slash.com/ The Syndicate: https://thesyndicate.com/ FAA Part 108 Explained: https://pilotinstitute.com/part-108-explained/ Zipline: https://www.zipline.com/ Google Wing: https://wing.com/ Joby Aviation: https://www.jobyaviation.com/ Enterprise Ireland: https://www.enterprise-ireland.com/ Éire Composites: https://www.eirecomposites.com/ Kimi K2.6 blog post: https://www.kimi.com/blog/kimi-k2-6 Kimi K2 series on GitHub: https://github.com/moonshotai/Kimi-K2 NVIDIA GB300 NVL72 work station: https://www.nvidia.com/en-us/data-center/gb300-nvl72/ Timestamps: 0:00 Josh from Eragon AI joins the show 2:01 Plaud: If your work depends on conversations — interviews, meetings, calls — you need a Plaud NotePin. You can check it out at https://Plaud.ai/twist and use code TWIST for 10% off! 5:07 Why founders should own and control their data sets 8:33 What is a "company world model?" 9:48 Quo (formerly OpenPhone) - Quo gives you a clean, modern way to handle every customer call, text, and thread all in one place. Try it free at https://quo.com/TWiST 11:32 Eragon demo 15:55 Giving agents their own bank accounts 19:07 Inside Eragon's first partnerships 20:14 Vanta - Get $1000 off your SOC 2 at https://www.vanta.com/twist 25:50 How does Eragon make money? 29:11 Pilot - Visit https://www.pilot.com/twist and get $1,200 off your first year. 39:33 Etienne Louvet of Iona Drones joins the show 42:37 What is FAA's Part 108? 47:13 How innovation in drones impacts the aviation industry 50:26 Working with Enterprise Ireland 58:28 Jason attended the Breakthrough Awards 1:04:10 Doug Liman's AI-powered "Bitcoin" movie 1:09:09 "Love Story" on FX and "Dust Bunny" on HBO Max 1:13:10 Jason's love of tinned fish Subscribe to the TWiST500 newsletter: https://ticker.thisweekinstartups.com Check out the TWIST500: https://www.twist500.com Subscribe to This Week in Startups on Apple: https://rb.gy/v19fcp Follow Lon: X: https://x.com/lons Follow Alex: X: https://x.com/alex LinkedIn: ⁠https://www.linkedin.com/in/alexwilhelm Follow Jason: X: https://twitter.com/Jason LinkedIn: https://www.linkedin.com/in/jasoncalacanis Check out all our partner offers: https://partners.launch.co/ Great TWIST interviews: Will Guidara, Eoghan McCabe, Steve Huffman, Brian Chesky, Bob Moesta, Aaron Levie, Sophia Amoruso, Reid Hoffman, Frank Slootman, Billy McFarland Check out Jason’s suite of newsletters: https://substack.com/@calacanis Follow TWiST: Twitter: https://twitter.com/TWiStartups YouTube: https://www.youtube.com/thisweekin Instagram: https://www.instagram.com/thisweekinstartups TikTok: https://www.tiktok.com/@thisweekinstartups Substack: https://twistartups.substack.com

This Week In Startups is made possible by:IM8 Health - https://IM8health.com/twist Grasshopper Bank - https://grasshopper.bank/twist Northwest Registered Agent - https://northwestregisteredagent.com/twist Plaud - https://Plaud.ai/twistToday’s show:Is 3D printing the key to not just solving the housing crisis but bringing us all into a more beautiful and utopian future? ICON founder Jason Ballard thinks so. His company is already building homes for the unhoused and delivering barracks to Fort Bliss at half the cost and a fraction of the time. On TWiST, he tells us space construction is also on the agenda.Explore the potential for robot-powered concrete construction can help build cheap homes for the unhoused, modernize our military infrastructure, AND colonize the solar system in this exclusive interview.Then Seby Rubino of Resi Labs demos his real estate “Oracle,” which can guess the price of any home with 98% accuracy… for just fractions of a penny.PLUS Jason tells a story of the rare founder who got one over on him, and why he’s moving away from vengeance and anger and into love and acceptable.AND we’ve got more JCal and Lon recommendations in a brand-new Off Duty.Guests :Jason Ballard: https://x.com/JasonDBallardICON: https://www.iconbuild.com/ICON on X: https://x.com/ICON3DTechSeby Rubino: https://x.com/SebyverseResi Labs: https://portal.resilabs.ai/Timestamps:0:00 Intro + "balance the ledger" tease1:10 Jason Ballard (ICON) joins — 3D-printed homes + defense (ICON Prime)5:18 Housing basics: commutes, quality of life, "food/water/shelter"7:15 ICON Prime: military construction, survivability, speed, supply chain10:08 IM8 Health: Start feeling like your best self every day. Go to https://IM8health.com/twist and use the code TWiST to get a free welcome kit, five free travel sachets, and 10% off your order.11:35 Plaud: If your work depends on conversations — interviews, meetings, calls — you need a Plaud NotePin. You can check it out at https://Plaud.ai/twist and use code TWIST for 10% off!12:43 Fort Bliss barracks: 10 in 6 months, half the cost; blast/ballistics20:23 Beautiful + dignified housing: Community First Village; "where's the floor?"20:29 Grasshopper Bank: Time is money. Don't waste either. Go to https://grasshopper.bank/twist and get an exclusive $500 cash bonus just for opening an account.30:10 Northwest Registered Agent - Get more when you start your business with Northwest. In 10 clicks and 10 minutes, you can form your company and walk away with a real business identity — Learn more at https://www.northwestregisteredagent.com/twist37:27 Audience Q&A: longevity/cracking; plumbing + electrical41:33 ICON Titan printer + channel partners; hiring pitch45:47 Sebi Rubino (Rezzy Labs) joins — BitTensor subnet 46 real estate pricing51:18 Tau/BitTensor explained: subnet competitions, "narrow intelligence"59:15 Rezzy demo: portal + pricing engine; customers + business model1:07:49 "Got shivved for 500k" story: acquisition, investors get zero1:20:36 Bounties: annotated.com + AI sidebar + headless CMS on BitTensor1:31:10 Off-duty: View Buds (camera earbuds) + use cases1:38:13 Off-duty: Anker charger/cable/battery "trio"1:41:12 Off-duty: The Audacity (AMC) quick review1:46:43 Wrap-up + secret TWiST group chat on XSubscribe to the TWiST500 newsletter: https://ticker.thisweekinstartups.comCheck out the TWIST500: https://www.twist500.comSubscribe to This Week in Startups on Apple: https://rb.gy/v19fcpFollow Lon:X: https://x.com/lonsFollow Jason:X: https://twitter.com/JasonLinkedIn: https://www.linkedin.com/in/jasoncalacanisCheck out all our partner offers: https://partners.launch.co/Great TWIST interviews: Will Guidara, Eoghan McCabe, Steve Huffman, Brian Chesky, Bob Moesta, Aaron Levie, Sophia Amoruso, Reid Hoffman, Frank Slootman, Billy McFarlandCheck out Jason’s suite of newsletters: https://substack.com/@calacanis

This Week In Startups is made possible by: LinkedIn Jobs - LinkedIn.com/twist Every.io - every.io Render - render.com/twist Today’s show: *Imagine scrolling through mobile games the way your flip through your TikTok feed. What if you could build your own game in 90 seconds and share it with the world? That’s what over 100,000 users are enjoying right now on Nanogram. On TWiST, we meet the co-founders: 22-year-old CEO Albert Brotherton and 24-year-old CTO Boris Radilov. They demo the app for us on the air, and Jason immediately spies the potential. Power users are playing 25+ games per session already. We’re digging into the co-founders future plans, including the potential for ads in your game feed, in this TWiST exclusive. PLUS domestic helper bots are here. NEO from 1X Technologies can do the laundry, open the door for guests, and even read and understand Post-It Note messages. Alex talks with CEO Bernt Børnich about building the safety-first 66-lb humanoid, why world models are so crucial for training robots in particular, and why homes are even tougher places for robots to navigate than factory floors. Timestamps:0:59 Nanogram co-creators Albert and Boris join the show 3:42 Nanogram is TikTok for casual AI-generated games 4:27 Building Nanogram with Google Gemini 5:49 Draper and Associates: https://www.draper.vc 6:11 Integrating ads into the game feed 7:36 Roblox: https://www.roblox.com World of Warcraft: https://worldofwarcraft.blizzard.com 8:25 Building in New York 9:07 Jason is obsessed with the Staples Baddie https://www.tiktok.com/@blivxx 10:12 LinkedIn Jobs - Hire right, the first time. Post your first job and get $100 off towards your job post at https://LinkedIn.com/twist 20:36 Every.io - For all of your incorporation, banking, payroll, benefits, accounting, taxes or other back-office administration needs, visit https://every.io 21:40 1X CEO and founder Bernt Børnich joins the show https://x.com/BerntBornich 22:31 Designing robots to actually live around people 26:30 Teaching NEO about movement in the physical world 29:00 TechCrunch coverage: https://techcrunch.com/2026/01/13/neo-humanoid-maker-1x-releases-world-model-to-help-bots-learn-what-they-see/ 29:58 Render: Find out why 5 million developers are already using the all-in-one cloud platform, Render. Go to https://render.com/twist and apply for the Render Startup Program to get $500-$100,000 in free credits, depending on your stage and backers. 31:04 Moving beyond training data to true general intelligence 33:17 Ensuring NEO pursues the safest possible path 34:19 Why are world models so important? 41:51 1X World Model Challenge on GitHub: https://github.com/1x-technologies/1xgpt 45:14 Robots need to train on a lot of data… Where does it all come from? 50:14 Manufacturing NEO from raw materials in San Carlos 56:32 Robots building robots Subscribe to the TWiST500 newsletter: https://ticker.thisweekinstartups.com Check out the TWIST500: https://www.twist500.com Subscribe to This Week in Startups on Apple: https://rb.gy/v19fcp Follow Lon: X: https://x.com/lons Follow Alex: X: https://x.com/alex LinkedIn: ⁠https://www.linkedin.com/in/alexwilhelm Follow Jason: X: https://twitter.com/Jason LinkedIn: https://www.linkedin.com/in/jasoncalacanis Check out all our partner offers: https://partners.launch.co/ Great TWIST interviews: Will Guidara, Eoghan McCabe, Steve Huffman, Brian Chesky, Bob Moesta, Aaron Levie, Sophia Amoruso, Reid Hoffman, Frank Slootman, Billy McFarland Check out Jason’s suite of newsletters: https://substack.com/@calacanis Follow TWiST: Twitter: https://twitter.com/TWiStartups YouTube: https://www.youtube.com/thisweekin Instagram: https://www.instagram.com/thisweekinstartups TikTok: https://www.tiktok.com/@thisweekinstartups Substack: https://twistartups.substack.com

This Week In Startups is made possible by: Sentry - https://sentry.io/twist Deel - https://deel.com/twist Netsuite - https://netsuite.com/twist Plaud - https://Plaud.ai/twist Today’s show: *TAO just had its worst week since launch. One of Bittensor’s most prominent subnet operators allegedly dumped $10 million in tokens and walked away. We’re digging into what we know, how this could change the Bittensor community… and why dedicated builders still believe in this ecosystem. Jason and Lon are joined by Stillcore Capital Partner Mark Jeffrey to break down the Covenant AI and Templar controversy in real time. Then they’re joined by three prominent subnet founders: Ken Miyachi of BitMind (Subnet 34) and Will Squires of Steffen Cruz of MacroCosmos (which owns Subnets 1, 9, and 13). Together, they’re investigating how Bittensor incentives work, how real products are still emerging from the TAO ecosystem, and what governance fixes could arise to prevent the next (alleged) rug pull. Timestamps: 0:00 Mark Jeffrey joins the show! https://x.com/markjeffrey 2:18 How Mark Jeffrey learned about Bittensor. https://bittensor.com/ 6:17 Plaud: If your work depends on conversations — interviews, meetings, calls — you need a Plaud NotePin. You can check it out at https://Plaud.ai/twist and use code TWIST for 10% off! 7:22 Mark Jeffrey's Bittensor investments. https://stillcorecapital.com/ 9:25 Check out our discussion with Nova: https://youtu.be/gjRt4eUyiYc?si=HopdmmSarxECark1 10:16 Sentry - New users can get $240 in free credits when they go to https://sentry.io/twist and use the code TWIST 10:41 Check out Ridges! https://www.ridges.ai/ 11:53 How trading alpha tokens works on Bittensor 12:44 Subnet drama: what happened? https://x.com/covenant_ai/status/2042380152831951300 16:01 Do subnet owners have too much power? 18:33 Check out our conversation with Sam Dare (2268): https://youtu.be/TN2RmNuX4-k?si=c58Byh7Fsw1ttnAY 19:10 How Sam Dare should've handled walking away (per Mark Jeffrey) 20:02 Deel - Founders scale faster on Deel. Set up payroll for any country in minutes, hire anyone anywhere, get visas handled fast, and get back to building. Visit https://deel.com/twist to learn more. 23:29 Who should subnets be owned by? 24:02 Ken Miyachi from BitMind joins the show https://x.com/kenmiyachi 30:56 Netsuite - Get the free business guide Demystifying AI at https://www.netsuite.com/twist 31:06 Ken's $3M raise & investors (Arch, Canonical, Mechanism) 33:18 Token vs. equity: how to think about a subnet investment. 41:57 Will Squires and Stefan Kruse of MacroCosmos join the show https://x.com/willsquires https://x.com/sczsteffencruz 56:29 Stefan on the Covenant drama: "disappointing, but solvable" 1:02:11 Off-duty with J-Cal, Mark Jeffrey, and Lon Harris 1:02:48 Bieber vs. Carpenter: does Coachella owe you a spectacle? https://www.youtube.com/watch?v=hp5O72WUqTk https://x.com/FashionXGirl_/status/2043251270509592936 1:15:20 Jason says Staples should pay the "Staples baddie" $1M/year https://www.tiktok.com/@blivxx Subscribe to the TWiST500 newsletter: https://ticker.thisweekinstartups.com Check out the TWIST500: https://www.twist500.com Subscribe to This Week in Startups on Apple: https://rb.gy/v19fcp Follow Lon: X: https://x.com/lons LinkedIn: ⁠https://www.linkedin.com/in/alexwilhelm Follow Jason: X: https://twitter.com/Jason LinkedIn: https://www.linkedin.com/in/jasoncalacanis Check out all our partner offers: https://partners.launch.co/ Great TWIST interviews: Will Guidara, Eoghan McCabe, Steve Huffman, Brian Chesky, Bob Moesta, Aaron Levie, Sophia Amoruso, Reid Hoffman, Frank Slootman, Billy McFarland Check out Jason’s suite of newsletters: https://substack.com/@calacanis Follow TWiST: Twitter: https://twitter.com/TWiStartups YouTube: https://www.youtube.com/thisweekin Instagram: https://www.instagram.com/thisweekinstartups TikTok: https://www.tiktok.com/@thisweekinstartups Substack: https://twistartups.substack.com

This Week In Startups is made possible by: Pilot - https://pilot.com/TWIST Squarespace -https://squarespace.com/TWIST Northwest Registered Agent - https://northwestregisteredagent.com/TWIST Plaud - https://Plaud.ai/twistCrowdHealth - ⁠https://JoinCrowdHealth.com/twist⁠ Today’s show: TAO, the token associated with the Bittensor network, fell sharply last night after a major project declared it was taking its business elsewhere. Covenant AI had used Bittensor subnets 3, 39, and 89 before its abrupt and controversial decision to depart for other digital shores. Gareth Howells, a co-founder of Vidaio (Bittensor Subnet 85), joined Jason and Alex to share the community perspective regarding Covenant’s decision to leave Bittensor, a choice that was especially bitter given that its recently-released Covenant-72B model trained using the network’s decentralized capabilities was hailed at the time as a demonstration of the crypto-AI hybrid’s potential. (Covenant’s Sam Dare was a recent guest on TWiST.) Howells walked us through Vidaio’s product (AI models for high-quality video work, like upscaling) Then it was time to bring new fan-favorite Ole Lehmann on. Ole took an Andrej Karpathy concept, and turned it into a skill that you can use in either OpenClaw or Claude Cowork. Guests Ole Lehmann: https://x.com/itsolelehmann The AI Solopreneur newsletter: https://aisolo.beehiiv.com/ Vidaio: https://vidaio.io/ Vidaio on X: https://x.com/vidaio_ Timestamps: 0:00 Drama in the Bittensor space! Was there a rugpull? 1:01 Plaud: If your work depends on conversations — interviews, meetings, calls — you need a Plaud NotePin. You can check it out at https://Plaud.ai/twist and use code TWIST for 10% off! 1:47 Gareth Howells of subnet85 joins the show: https://x.com/GarethHowells 9:56 Northwest Registered Agent - Get more when you start your business with Northwest. In 10 clicks and 10 minutes, you can form your company and walk away with a real business identity — Learn more at https://northwestregisteredagent.com/TWIST 11:37 Gareth reacts to the Covenant situation… Did Sam sell tokens? 14:33 How VidAIo (subnet85) optimizes video as cheaply as possible. https://vidaio.io/ 20:06 Squarespace - Use offer code TWIST to save 10% off your first purchase of a website or domain at https://squarespace.com/TWIST 21:12 Demo: Gareth shows upscaled footage of our very own Lon Harris 27:09 Who is actually doing the computing on Bittensor? 28:15 How Bittensor recruits tech talent from emerging markets 29:42 Pilot - Visit https://pilot.com/TWIST and get $1,200 off your first year. 30:58 Jason's explains the Bittensor network. https://docs.bittensor.com/ 37:28 Jason addresses "pump and dump" allegations 40:46 Ole Lehmann joins the show https://x.com/itsolelehmann 45:31 Jason's $1,000 "bounty" for enhanced show notes 49:35 Check out Ole's newsletter at aisolo.beehiiv.com ! 59:50 CrowdHealth - CrowdHealth lets you ditch the bureaucracy with a peer-to-peer funding platform for your healthcare. Get started for $99 per month for your first three months by using the code TWIST at https://JoinCrowdHealth.com/twist. 1:00:46 Off Duty with Alex and J-Cal! 1:04:46 Reacting to the Maul trailer https://www.youtube.com/watch?v=DkVepshZhGc Subscribe to the TWiST500 newsletter: https://ticker.thisweekinstartups.com Check out the TWIST500: https://www.twist500.com Subscribe to This Week in Startups on Apple: https://rb.gy/v19fcp Follow Lon: X: https://x.com/lons Follow Alex: X: https://x.com/alex LinkedIn: ⁠https://www.linkedin.com/in/alexwilhelm Follow Jason: X: https://twitter.com/Jason LinkedIn: https://www.linkedin.com/in/jasoncalacanis Follow TWiST: Twitter: https://twitter.com/TWiStartups YouTube: https://www.youtube.com/thisweekin Instagram: https://www.instagram.com/thisweekinstartups TikTok: https://www.tiktok.com/@thisweekinstartups Substack: https://twistartups.substack.com

Anthropic just built a model so dangerous, they’re not even going to release it (for now). On TWiST, Jason, Alex, and Neurometric CEO Rob May discuss whether or not this is just another frontier model or a potential weapon of mass internet destruction. Claude Mythos Preview is already in the hands of over 40 Anthropic partners — including Nvidia, Apple, Amazon, Microsoft, and Google — as part of its “Project Glasswing” security council. Together, they’ll test how quickly and easily the model can thwart today’s most elite cybersecurity protocols, and try to develop fresh protocols to keep our most sensitive and critical software systems safe and intact. Once Mythos or a similarly powerful model hits the streets… it’s all over! Plus, we’re checking out the real-time SaaSpocalypse monitor Death By Clawd, and chatting with its creator, Gyani, about how it feels to have your startup one-shotted by Anthropic’s latest model. Guests Rob May: https://x.com/robmay Neurometric: https://www.neurometric.ai/ Neurometric SLM Marketplace: https://marketplace.neurometric.ai/ Death by Clawd: https://deathbyclawd.com/ Nick O’Neill: https://x.com/chooserich This Week In Startups is made possible by: LinkedIn Jobs - LinkedIn.com/twist Grasshopper Bank - Grasshopper.bank/twist Render - Render.com/twist Plaud - https://Plaud.ai/twist Today’s show: Timestamps: 0:00 Anthropic's new, powerful 'Mythos' model 3:50 Plaud: If your work depends on conversations — interviews, meetings, calls — you need a Plaud NotePin. You can check it out at https://Plaud.ai/twist and use code TWIST for 10% off! 5:26 Neurometric's Rob May joins the show 10:04 Sam Altman's talent exodus 10:50 Render - Go to https://render.com/twist to apply for the Render Startup Program. You'll get anywhere from $500 to $100,000 in free credits. 11:50 Has Anthropic Passed OpenAI? 15:44 When will Claude release Mythos? Polymarket: https://polymarket.com/event/claude-mythos-released-by 18:32 The AI race turns existential 19:16 Would Anthropic's model give the CIA the ability to hack a foreign government? 20:04 Grasshopper Bank - Time is money. Don't waste either. Go to https://grasshopper.bank/twist and get an exclusive $500 cash bonus just for opening an account. 21:19 Should AI be nationalized? 29:43 Subsidizing secret AI development. 30:15 LinkedIn Jobs - Hire right, the first time. Post your first job and get $100 off towards your job post at https://LinkedIn.com/twist 31:29 How much of the military's $1.5T will go to AI cybersecurity? 35:17 Nick O'Neill's "not sponsored" call-in. 38:24 What is an SLM? 42:01 Tactical/Practical: How can you tune SLMs 45:43 How Neurometric can afford 100M free tokens per month for its users? 49:04 What is "harness engineering"? 50:58 Tactical/ Practical: Every Reddit rant is a startup idea 1:00:25 Why Meta is the most un-innovative AI company in the world. 1:03:43 Gyani of Deathbclawd joins the show — Is your company COOKED? Subscribe to the TWiST500 newsletter: https://ticker.thisweekinstartups.com Check out the TWIST500: https://www.twist500.com Subscribe to This Week in Startups on Apple: https://rb.gy/v19fcp Follow Lon: X: https://x.com/lons Follow Alex: X: https://x.com/alex LinkedIn: ⁠https://www.linkedin.com/in/alexwilhelm Follow Jason: X: https://twitter.com/Jason LinkedIn: https://www.linkedin.com/in/jasoncalacanis Check out all our partner offers: https://partners.launch.co/ Great TWIST interviews: Will Guidara, Eoghan McCabe, Steve Huffman, Brian Chesky, Bob Moesta, Aaron Levie, Sophia Amoruso, Reid Hoffman, Frank Slootman, Billy McFarland Check out Jason’s suite of newsletters: https://substack.com/@calacanis Follow TWiST: Twitter: https://twitter.com/TWiStartups YouTube: https://www.youtube.com/thisweekin Instagram: https://www.instagram.com/thisweekinstartups TikTok: https://www.tiktok.com/@thisweekinstartups Substack: https://twistartups.substack.com

Anthropic just pulled the plug on Claude subscriptions for OpenClaw and every third party agentic tool. So Jason and Lon welcome back three of our top TWiST OpenClaw experts to break down what it means, how much it’s going to cost now, and whether this is truly the end of the subsidized AI era. And they all brought demos! We’re checking out ClawChief from Ryan Carson, Alex Finn’s agent Henry, and Yazin Alirhayim’s Sidecast protocol, inspired by a special request from JCal! Hosts Jason Calacanis: http://x.com/jason Lon Harris: https://x.com/lons Guests Ryan Carson: https://x.com/ryancarson Clawchief: https://github.com/snarktank/clawchief Alex Finn: https://x.com/AlexFinn Creator Buddy: https://www.creatorbuddy.io/ Yazin Alirhayim: https://x.com/yazins OpenOats / Sidecast: https://github.com/yazinsai/OpenOats Further Reading The Checklist Manifesto by Atul Gawande: https://www.amazon.com/Checklist-Manifesto-How-Things-Right/dp/0312430000 Marc Andreessen on AI job loss: https://x.com/pmarca/status/2040919227641856307 OpenAI acquires TBPN: https://openai.com/index/openai-acquires-tbpn/ This Week In Startups is made possible by: Gusto - https://Gusto.com/twist Vanta - https://vanta.com/twist Shopify - https://shopify.com/twist Plaud - https://Plaud.ai/twist Today’s show: Timestamps: 0:00 Welcome back to TWiST 0:32 Jason's thinks Andor is as good as Empire Strikes Back… 2:30 Plaud: If your work depends on conversations — interviews, meetings, calls — you need a Plaud NotePin. You can check it out at https://Plaud.ai/twist and use code TWIST for 10% off! 3:26 Check out the checklist manifesto! https://www.amazon.com/Checklist-Manifesto-How-Things-Right/dp/0312430000 6:36 Our guests Ryan Carson, Alex Finn, and Yazin Alirhayim, and join the show 10:28 Gusto - Check out the online payroll and benefits experts with software built specifically for small businesses and startups. Try Gusto today and get three months FREE at https://Gusto.com/twist. 10:46 People are automating their coworkers and getting them fired… 18:32 Anthropic Bans OpenClaw 20:06 Vanta - Get $1000 off your SOC 2 at https://www.vanta.com/twist 24:06 How "caveman talk" makes AI works better 27:31 Alex thinks $2000/ month subscription plans are inevitable for AI. 29:31 Why is nobody using the leaked Anthropic Model? 30:30 Shopify: Turn those What If's into sales with the ecommerce platform powering millions of businesses. Sign up for your $1-per-month trial today at https://shopify.com/twist 32:37 Open models have been 6 months behind for the past few years 35:53 Why did OpenAI acquire TBPN? 42:01 Tactical/ Practical: The product itself is the most important thing 44:31 Demo or Die! Yazin is back to show off OpenOats 55:05 Ryan's "Claw Chief" https://github.com/snarktank/clawchief/blob/main/skills/executive-assistant/SKILL.md?plain=1 1:02:14 Alex's big announcement, "Henry intelligent machines" 1:12:33 Alex Finn DESTROYS Higgsfield's marketing strategy 1:15:35 Throwback to "Pay Per Post" Subscribe to the TWiST500 newsletter: https://ticker.thisweekinstartups.com Check out the TWIST500: https://www.twist500.com Subscribe to This Week in Startups on Apple: https://rb.gy/v19fcp Follow Lon: X: https://x.com/lons Follow Alex: X: https://x.com/alex LinkedIn: ⁠https://www.linkedin.com/in/alexwilhelm Follow Jason: X: https://twitter.com/Jason LinkedIn: https://www.linkedin.com/in/jasoncalacanis Check out all our partner offers: https://partners.launch.co/ Great TWIST interviews: Will Guidara, Eoghan McCabe, Steve Huffman, Brian Chesky, Bob Moesta, Aaron Levie, Sophia Amoruso, Reid Hoffman, Frank Slootman, Billy McFarland Check out Jason’s suite of newsletters: https://substack.com/@calacanis Follow TWiST: Twitter: https://twitter.com/TWiStartups YouTube: https://www.youtube.com/thisweekin Instagram: https://www.instagram.com/thisweekinstartups TikTok: https://www.tiktok.com/@thisweekinstartups Substack: https://twistartups.substack.com

This Week In Startups is made possible by: Deel - deel.com/twist Grasshopper Bank - grasshopper.bank/twist Render - render.com/twist Plaud - Plaud.ai/twist An AI “holding company” rebuilt dozens of YC Winter ‘26 startups in one weekend. Now we’re bringing the founder responsible into Jason’s Courtroom to defend himself. PLUS a live demo of Boardy, the AI that acts like a virtual board member and makes crucial introductions. Find out why he gets to have so much agency, how creator Andrew D’Souza used him to raise his own $17 million round, and how this company ever plans to actually make money. Plus Jason celebrates Apple’s 50th anniversary with a fiery rant about milking the ghost of Steve Jobs… Why OpenAI is acquiring a tech podcast… Jason’s favorite weighted vest for rucking… AND Lon’s Off Duty weekend streaming picks. Guests Marik Hazan:⁠ https://x.com/MarikHazan⁠ Feltsense:⁠ https://feltsense.com/⁠ Andrew D’Souza:⁠ https://x.com/andrewdsouza⁠ Boardy:⁠ https://www.boardy.ai/⁠ Timestamps: 0:00 Jason's direction for TWiST and thoughts on legacy media 5:14 Marik of Feltsense joins the show 6:10 Plaud: If your work depends on conversations — interviews, meetings, calls — you need a Plaud NotePin. You can check it out at https://Plaud.ai/twist and use code TWIST for 10% off! 7:10 Marik's viral YC replicator stunt 9:45 Deel - Founders scale faster on Deel. Set up payroll for any country in minutes, hire anyone anywhere, get visas handled fast, and get back to building. Visit https://deel.com/twist to learn more. 20:39 Grasshopper bank - Time is money. Don't waste either. Go to https://grasshopper.bank/twist and get an exclusive $500 cash bonus just for opening an account. 21:33 Feltsense founder goes on trial! 25:26 Jason dunks on Bank of America's app 27:59 TBPN acquired by OpenAI 29:28 The All In Podcast is worth $1B! 30:13 Render - Find out why 5 million developers are already using the all-in-one cloud platform, Render. Go to https://render.com/twist and apply for the Render Startup Program to get $500-$100,000 in free credits, depending on your stage and backers. 33:02 Andrew D'Souza joins the show along with his agent, Boardy! 43:17 So how does Boardy make money? 48:32 Lon is becoming more and more "AI-pilled." 50:41 Tactical/ practical: "If we have data, let's look at data. If all we have are opinions, let's go with mine." -Jim Barskdale, former CEO of Netscape 1:01:00 Tactical/ practical: hire a PR firm to report on your competitors' wrongdoings. 1:02:58 Jason calls out Apple for being DISGRAZIAD! 1:15:09 Lon's TV pick of the week: "Something Very Bad is Going to Happen https://www.youtube.com/watch?v=vMc_pWm7G7o 1:19:52 Become an Angel Investor at https://thesyndicate.com/ Subscribe to the TWiST500 newsletter:⁠ https://ticker.thisweekinstartups.com⁠ Check out the TWIST500:⁠ https://www.twist500.com⁠ Subscribe to This Week in Startups on Apple:⁠ https://rb.gy/v19fcp⁠ Follow Lon: X:⁠ https://x.com/lons⁠ Follow Alex: X:⁠ https://x.com/alex⁠ LinkedIn:⁠ ⁠https://www.linkedin.com/in/alexwilhelm⁠ Follow Jason: X:⁠ https://twitter.com/Jason⁠ LinkedIn:⁠ https://www.linkedin.com/in/jasoncalacanis⁠ Check out all our partner offers:⁠ https://partners.launch.co/⁠ Great TWIST interviews:⁠ Will Guidara,⁠⁠ Eoghan McCabe⁠,⁠ Steve Huffman⁠,⁠ Brian Chesky⁠,⁠ Bob Moesta,⁠⁠ Aaron Levie⁠,⁠ Sophia Amoruso⁠,⁠ Reid Hoffman⁠,⁠ Frank Slootman⁠,⁠ Billy McFarland⁠ Check out Jason’s suite of newsletters:⁠ https://substack.com/@calacanis⁠ Follow TWiST: Twitter:⁠ https://twitter.com/TWiStartups⁠ YouTube:⁠ https://www.youtube.com/thisweekin⁠ Instagram:⁠ https://www.instagram.com/thisweekinstartups⁠ TikTok:⁠ https://www.tiktok.com/@thisweekinstartups⁠ Substack:⁠ https://twistartups.substack.com⁠

This Week in AI, JCal sits down with three CEOs building the infrastructure, intelligence, and interfaces for the next era of AI: Jeremy Fraenkel (CEO, Fundamental), Victor Riparbelli (CEO, Synthesia), and Nick Harris (CEO, Lightmatter). We break down what's actually happening beneath the AI hype: the data modality LLMs completely missed, why copper is the real bottleneck in AI data centers, OpenAI shutting down Sora, the build vs. buy debate for AI tools, and how close we really are to AGI. AI's Biggest Blind Spot, Tabular Data: LLMs transformed text, images, and code, but 70-80% of enterprise data lives in rows and columns.Copper Can't Keep Up: Nick explains why AI data centers are hitting a wall. GPUs compute faster than they can communicate. Lightmatter's photonic chips push 1.6 terabits per fiber and can 3x training speed.Why OpenAI Killed Sora & Anthropic's Focus is Winning: Victor breaks down why even OpenAI had to learn the lesson of focus, and why Claude Code has every founder talking.Vibe Coding Your Own CRM vs. Buying Salesforce: Jeremy reveals Fundamental built their own internal CRM using vibe coding. The panel debates when building beats buying and when it's a distraction.The Omnipresent CEO: Jason shares how he's using AI agents for root access to Slack, Gmail, and Notion, resurrecting former employees as AI personas, automating SDR workflows, and summarizing employee inboxes while they're on vacation.Are We Already at AGI?: Nick says the rate of progress is a double exponential. Jeremy argues AGI is a moving goalpost. Victor warns of "Future Shock" and societal disruption.🔗 Learn more about Fundamental: https://fundamental.tech🔗 Learn more about Synthesia: https://www.synthesia.io🔗 Learn more about Lightmatter: https://lightmatter.coThis Week In AI is made possible by:PayPal Open - One Platform for all Business: paypalopen.comTimestamps:00:00 Welcome & intro to Jeremy Fraenkel, Victor Riparbelli, and Nick Harris01:47 What is Fundamental? Large tabular models explained07:01 Victor Riparbelli on Synthesia & why OpenAI killed Sora11:09 Claude Code dominance & the Lightspeed founder retreat12:08 Nick Harris on Lightmatter, photonics & the new Moore's Law14:38 Copper vs. fiber: why AI data centers are hitting a wall18:44 Reinventing video: interactive, real-time, personalized21:32 The economics of a custom AI movie23:55 Why Amazon, Google & Meta are building their own chips28:06 Tables have a bandwidth problem too32:27 When will compute be as cheap as storage?36:10 The future of software: every company gets a custom stack38:06 Vibe coding your own CRM vs. buying Salesforce45:57 Jason's quest for root access to Slack50:18 The omnipresent CEO: Doctor Manhattan meets Jesus CEO52:13 Resurrecting former employees as AI personas53:25 Victor's executive changelog for a 650-person company55:07 Whisper Flow & the Plaud Pin1:00:03 AGI: is it already here?1:03:37 Jeremy: we've only solved half the brain1:06:30 70% of Americans fear AI will impact jobs1:08:47 Future Shock & keeping the rope tight*Mentioned in the show:* Wisper Flow: https://wisperflow.ai Plaud Pin: https://www.plaud.aiAthena Executive Assistants: https://www.athenawow.comWHOOP: https://www.whoop.com"Future Shock" by Alvin Toffler: https://www.amazon.com/Future-ShockAlvin-Toffler/dp/0394425863Victor on TWiST, E1776: https://youtu.be/jxET4fq_2eANick on TWiST, E1787: https://youtu.be/FPW2nnEqfMsSubscribe to This Week in AI on Apple: https://thisweekinai.ai/spotifySubscribe to This Week in AI on Spotify: https://thisweekinai.ai/appleThanks for watching!🤖 If you want to stay ahead of the curve on all things AI, make sure to join our community across all platforms:📩 Get the Weekly Newsletter: https://thisweekinai.ai/📺 Subscribe on YouTube: https://www.youtube.com/@ThisWeekinAIPodcast📸 Instagram: https://www.instagram.com/thisweekinaipodcast

This Week In Startups is made possible by: PaperOS - https://PaperOS.com/twist Northwest Registered Agent- https://northwestregisteredagent.com/twist Every.io - https://Every.io Plaud - https://Plaud.ai/twist Today’s show: Silicon Valley just lined up its biggest liquidity event in years: SpaceX filed confidentially for an IPO that could target a $1.75 trillion valuation — potentially the largest public offering in history. Meanwhile, a new Quinnipiac poll shows that 62% of Americans aren't excited about AI, and 70% think it will destroy their jobs. The disconnect between Sand Hill Road and Main Street has never been wider, and this panel is here to argue about what to do about it. Jason Calacanis and co-host Alex Wilhelm are joined by Delian Asparouhov, Partner at Founders Fund and co-founder of Varda Space Industries; Salen Churi, General Partner at Trust Ventures, focused on regulated industries and physical infrastructure; and Larsen Jensen, Founder and GP of Harpoon Ventures and former Navy SEAL. They dig into the SpaceX IPO and what it means for LP liquidity, founder formation, and venture capital's comeback story; the gap between Silicon Valley's AI optimism and public hostility; whether defense tech is in a bubble after $49 billion flooded the sector in 2025; the Marc Andreessen "zero introspection" thesis for founders; America's reindustrialization challenge and the rare earths supply chain crisis; and Artemis’s path to putting boots back on the Moon. Timestamps: 00:00 Intro 1:09 Plaud: If your work depends on conversations — interviews, meetings, calls — you need a Plaud NotePin. You can check it out at https://Plaud.ai/twist and use code TWIST for 10% off! 3:50 SpaceX files confidentially for IPO: $1.75T valuation, June target 9:00 Will the SpaceX IPO reinvigorate venture capital? 10:25 Every.io - For all of your incorporation, banking, payroll, benefits, accounting, taxes or other back-office administration needs, visit https://every.io 14:40 Quinnipiac poll: Americans use more AI but trust it less 17:31 AI's PR crisis: Dario vs. Jensen, and who's communicating well 18:02 Jason's "Invest America" proposal: give workers equity stakes 19:55 Northwest Registered Agent - Get more when you start your business with Northwest. In 10 clicks and 10 minutes, you can form your company and walk away with a real business identity — Learn more at https://northwestregisteredagent.com/twist 21:39 Larsen: Silicon Valley is walking into the same trap as China offshoring 29:04 PaperOS - Whether you're raising a round, launching a fund, or managing a venture portfolio, PaperOS can unlock simplicity and scale across your empire of capital, contracts, and companies. Claim your $10,000 credit at https://paperos.com/twist 29:50 Polymarket: 24% chance of a federal AI data center moratorium 33:57 Marc Andreessen on zero introspection (David Senra podcast clip) 46:48 Is defense tech in a bubble? 1:10:32 Saronic raises $1.75B for autonomous drone boats 1:25:07 Anthropic vs. OpenAI: where would you put your entire net worth? Subscribe to the TWiST500 newsletter: https://ticker.thisweekinstartups.com Check out the TWIST500: https://www.twist500.com Subscribe to This Week in Startups on Apple: https://rb.gy/v19fcp Follow Alex: X: https://x.com/alex LinkedIn: ⁠https://www.linkedin.com/in/alexwilhelm Follow Jason: X: https://twitter.com/Jason LinkedIn: https://www.linkedin.com/in/jasoncalacanis Check out all our partner offers: https://partners.launch.co/ Great TWIST interviews: Will Guidara, Eoghan McCabe, Steve Huffman, Brian Chesky, Bob Moesta, Aaron Levie, Sophia Amoruso, Reid Hoffman, Frank Slootman, Billy McFarland Check out Jason’s suite of newsletters: https://substack.com/@calacanis Follow TWiST: Twitter: https://twitter.com/TWiStartups YouTube: https://www.youtube.com/thisweekin Instagram: https://www.instagram.com/thisweekinstartups TikTok: https://www.tiktok.com/@thisweekinstartups Substack: https://twistartups.substack.com

This Week In Startups is made possible by: Quo - https://quo.com/TWiST LinkedIn Jobs - https://LinkedIn.com/twist Iru - https://iru.com/twist Plaud - https://Plaud.ai/twist Today’s show: Google project manager Shubham Saboo is running 6 AI agents on a Mac Mini that handle all of his side business autonomously, from research, to social posts, to newsletters. He joins Jason and Lon to walk us through his 5-step framework for designing an efficient AI agent team: Start with one agent and onboard them like a new hire Stop Googling fixes; just ask your agent how to use it Put your agents on fixed schedules Add shared memory so you don’t have to repeat yourself Let agents run self-reviews and rewrite their own instructions. Get the walkthrough to put this entire plan into practice on today’s episode. PLUS fresh demos of the “Minecraft”-inspired virtual workspace MoltWorld and AgentMail, which is Gmail for your AI pals, and Jason explains the thinking behind his viral, controversy-stirring “don’t talk to journalists” tweet. Follow Shubham: https://x.com/Saboo_Shubham_ “How I Built an Autonomous AI Agent Team That Runs 24/7” on X: https://x.com/Saboo_Shubham_/status/2022014147450614038?s=20 Follow Mike: https://x.com/mihalich1988 MoltWorld: https://moltworld.io/ Follow Haakam: https://x.com/haakamaujla AgentMail: https://www.agentmail.to/ Jason’s post about talking to journalists: https://x.com/Jason/status/2037573025458016659 NYT responds: https://x.com/NYTimesPR/status/2037648223771263082 Translated Japanese tweets: https://x.com/melonneet40/status/2038020624015315289, https://x.com/rambling_28/status/2038041455999246422 Japanese people singing “Country Roads”: https://x.com/harukaawake/status/2038081269830222259 Trailer for “Nuremberg” (now on Netflix in the US): https://www.youtube.com/watch?v=WvAy9C-bipY Timestamps: 0:00 Intro 1:24 Plaud: If your work depends on conversations — interviews, meetings, calls — you need a Plaud NotePin. You can check it out at https://Plaud.ai/twist and use code TWIST for 10% off! 3:05 We're Claw-pilled once again; it's an all AI Agent showcase 6:15 Google AI PM Shubham Saboo's Top 5 OpenClaw tips 10:14 Quo (formerly OpenPhone) gives you a clean, modern way to handle every customer call, text, and thread all in one place. Try it free at https://quo.com/TWiST. 13:26 Tip #1 — Onboard your agent like a new hire 17:31 Tip #2 — Talk to your agents constantly 19:02 Tip #3 — Put your agents on a schedule 19:51 LinkedIn Jobs - Hire right, the first time. Post your first job and get $100 off towards your job post at https://LinkedIn.com/twist. 23:41 Tip #4 — Add cross-agent memory 29:33 Tip #5 — Let your agents self-improve 29:51 Iru unifies identity, endpoint security, and compliance into one platform. TWiST listeners get 20% off when they book a demo at https://iru.com/twist! 34:03 Why Jason says founders should avoid journalists 38:24 How biased IS the New York Times? 47:02 DEMO: Co-founder Mike Nosov shows us MoltWorld 51:14 But what's the utility of this? 1:05:15 DEMO: Haakam Aujla presents AgentMail (YC S25) 1:09:59 How does AgentMail make money? 1:17:03 How Grok Translations are creating cross-cultural dialogue on X Subscribe to the TWiST500 newsletter: https://ticker.thisweekinstartups.com Check out the TWIST500: https://www.twist500.com Subscribe to This Week in Startups on Apple: https://rb.gy/v19fcp Follow Lon: X: https://x.com/lons Follow Alex: X: https://x.com/alex LinkedIn: ⁠https://www.linkedin.com/in/alexwilhelm Follow Jason: X: https://twitter.com/Jason LinkedIn: https://www.linkedin.com/in/jasoncalacanis Check out all our partner offers: https://partners.launch.co/ Great TWIST interviews: Will Guidara, Eoghan McCabe, Steve Huffman, Brian Chesky, Bob Moesta, Aaron Levie, Sophia Amoruso, Reid Hoffman, Frank Slootman, Billy McFarland Check out Jason’s suite of newsletters: https://substack.com/@calacanis

This Week In Startups is made possible by: Wispr Flow - https://wisprflow.ai/twist Circle - http://circle.so/twist Deel - http://deel.com/twist Today’s show: AstroForge is building low-cost, replicable spacecraft to mine platinum group metals from near-Earth asteroids — a $60 billion annual market for materials that are running out on Earth. Founder and CEO Matt Gialich joins the show to talk about the company's ambitious mission, what went wrong on their first two flights, and why Mission 3 could still change everything. PLUS Sam Dare from Templar stops by to talk about training AI models on a decentralized blockchain, and why it’s so much cheaper and more efficient than the conventional “data center full of GPUs” method. AND a demo of OpenOats from creator Yazin Alirhayim of his open source Granola alternative. Astroforge: https://www.astroforge.com/ Templar: https://www.tplr.ai/ Epoch AI decentralized training post: https://epoch.ai/gradient-updates/how-far-can-decentralized-training-over-the-internet-scale OpenOats on Github: https://github.com/yazinsai/OpenOats Timestamps: 0:00 Intro 0:59 Plaud: If your work depends on conversations — interviews, meetings, calls — you need a Plaud NotePin. You can check it out at https://Plaud.ai/twist and use code TWIST for 10% off! 3:05 We aplaud Plaud! 3:18 Astroforge is mining… asteroids?! 6:11 How creating an abundance of Platinum will impact Humanity! 9:56 Wispr Flow: Stop typing. Dictate with Wispr Flow and send clean, final-draft writing in seconds. Visit https://wisprflow.ai/twist to get started for free today. 21:16 Circle: The easiest way to build a home for your community, events, and courses — all under your own brand. TWiST listeners get $1,000 off the Circle Plus Plan by going to https://circle.so/twist. 22:01 How Astroforge uses capitalism to unlock abundance 24:35 J-Cal subscribed to… A socialist magazine? 26:19 Sam Dare of Templar joins the show! 27:47 What is TAO doing that's uniquely different from Bitcoin 30:15 What is the incentive mechanism that Templar uses? 30:44 Deel - Founders scale faster on Deel. Set up payroll for any country in minutes, hire anyone anywhere, get visas handled fast, and get back to building. Visit https://deel.com/twist to learn more. 37:49 How much does it cost to run templar's model? 45:16 Can decentralized training over the internet scale? https://epoch.ai/gradient-updates/how-far-can-decentralized-training-over-the-internet-scale 47:16 Jason addresses his tao investment 48:48 Why brand is the moat for startups 49:47 When will a better, more exciting version of Bitcoin, can come along? 52:20 Yazin of OpenGranola Joins the show 53:36 How OpenGranola has local LLM's taking notes for you and giving you real time insights in your meeting! 1:01:45 Jason's callout for a sidebar that shows all inputs from agents 1:13:50 The economics of the new harry potter series and HBO/ Warner Brothers 1:23:33 Why Jason wants government surveillance on Disney adults… Subscribe to the TWiST500 newsletter: https://ticker.thisweekinstartups.com Check out the TWIST500: https://www.twist500.com Subscribe to This Week in Startups on Apple: https://rb.gy/v19fcp Follow Lon: X: https://x.com/lons Follow Alex: X: https://x.com/alex LinkedIn: ⁠https://www.linkedin.com/in/alexwilhelm Follow Jason: X: https://twitter.com/Jason LinkedIn: https://www.linkedin.com/in/jasoncalacanis Check out all our partner offers: https://partners.launch.co/ Great TWIST interviews: Will Guidara, Eoghan McCabe, Steve Huffman, Brian Chesky, Bob Moesta, Aaron Levie, Sophia Amoruso, Reid Hoffman, Frank Slootman, Billy McFarland Check out Jason’s suite of newsletters: https://substack.com/@calacanis Follow TWiST: Twitter: https://twitter.com/TWiStartups YouTube: https://www.youtube.com/thisweekin Instagram: https://www.instagram.com/thisweekinstartups TikTok: https://www.tiktok.com/@thisweekinstartups Substack: https://twistartups.substack.com

This Week In Startups is made possible by: Luma AI - https://lumalabs.ai/twist Every.io -  https://every.io Lemon.io - https://Lemon.io/twistPlaud - https://Plaud.ai/twist Today’s show: What do drug discovery, the creator economy, and AI vision models have in common? In the case of Metanova, Bitcast, and Score, the answer is Bittensor. Yes, each of the three companies leverages the Bittensor network to get more work done, more quickly, in a completely decentralized fashion. Metanova uses its subnet to run developer competitions to find exciting molecular candidates, parsing through a mountain of possibilities to pluck out the most promising for further investigation. Bitcast uses its subnet to collect visibility demand from brands, which is served by video creators. The company is focused on the crypto niche to start, but will expand in time to other technology topics. Score uses its subnet to generate highly performant, specialized vision models, which it then sells to customers through a platform (Manako). In each case, the Bittensor’s economic engine unlocks global creativity to tackle tasks that were previously time-consuming, fragmented, or expensive to complete. Let’s see how quickly each company can scale and whether startups building on Bittensor can grow faster than their non-decentralized peers. Timestamps: 0:00 Intro 2:19 Plaud: If your work depends on conversations — interviews, meetings, calls — you need a Plaud NotePin. You can check it out at https://Plaud.ai/twist and use code TWIST for 10% off! 3:40 What is Bittensor? 7:22 Metanova Labs joins the show 9:28 Lemon.io - Get 15% off your first 4 weeks of developer time at https://Lemon.io/twist 17:16 How Metanova tackles the multi-billion dollar cost of drug discovery 20:48 Every.io - For all of your incorporation, banking, payroll, benefits, accounting, taxes or other back-office administration needs, visit https://every.io 30:20 Bitcast joins the show 31:23 Luma AI - Luma builds accessible, professional-grade AI tools for creatives. Try Luma Agents for free at https://lumalabs.ai/twist 32:30 Mining crypto with YouTube 36:48 Why Bitcast is focused on the crypto space to start 39:11 How healthy is the creator economy? 47:26 When will the AI bubble collapse? 53:44 Score joins the show 54:42 How Score will make vision AI more accessible 57:16 VLMs v. LLMs 1:01:14 Demo of the Manako platform Subscribe to the TWiST500 newsletter: https://ticker.thisweekinstartups.com Check out the TWIST500: https://www.twist500.com Subscribe to This Week in Startups on Apple: https://rb.gy/v19fcp Follow Lon: X: https://x.com/lons Follow Alex: X: https://x.com/alex LinkedIn: ⁠https://www.linkedin.com/in/alexwilhelm Follow Jason: X: https://twitter.com/Jason LinkedIn: https://www.linkedin.com/in/jasoncalacanis Check out all our partner offers: https://partners.launch.co/ Great TWIST interviews: Will Guidara, Eoghan McCabe, Steve Huffman, Brian Chesky, Bob Moesta, Aaron Levie, Sophia Amoruso, Reid Hoffman, Frank Slootman, Billy McFarland Check out Jason’s suite of newsletters: https://substack.com/@calacanis Follow TWiST: Twitter: https://twitter.com/TWiStartups YouTube: https://www.youtube.com/thisweekin Instagram: https://www.instagram.com/thisweekinstartups TikTok: https://www.tiktok.com/@thisweekinstartups Substack: https://twistartups.substack.com

This Week in AI sneak peak! If you enjoy the episode find us on Spotify, Apple podcasts and YouTube by looking up "This Week in AI" or by going to thisweekinai.ai This week Jason sat down with Jake Loosararian and Chris Lattner on Episode 6 of This Week in AI. Jake is the CEO and co-founder of Gecko Robotics, a company deploying purpose-built robots and AI for mission-critical infrastructure inspection across energy, defense, and manufacturing. Chris is the CEO and co-founder of Modular, building a universal software layer that lets developers run AI models across Nvidia, AMD, and Apple silicon without being locked into any single hardware vendor. We explore the GPU shortage, why China's chip smuggling reveals the stakes of the AI cold war, how purpose-built robotics are beating humanoids on ROI, the case for American reindustrialization, and why the next decade could be the best ever for private equity in capital-intensive industries. Purpose-Built Robots vs. Humanoids: Jake has been building mission-critical robots for 13 years. He explains why general-purpose humanoids still have too little ROI for industrial use, and why specialized robots that find and fix problems are winning in the field.The GPU Shortage Is Real: Chris breaks down why you can't just go buy 100 Blackwell chips today, why Nvidia's Cuda creates massive lock-in, and how Modular is building a unified software layer across all major chip architectures.Google TPUs Are the Sleeper: Chris ranks Google as the number one threat to Nvidia's dominance, ahead of Amazon's Trainium and AMD.China's Chip Smuggling & the AI Cold War: A Supermicro co-founder allegedly smuggled $2.5B in Nvidia chips to China using fake serial numbers and a hairdryer. The Best Decade for Private Equity: Jake makes the case that capital-intensive, commoditized infrastructure assets: waste-to-energy, water treatment, old power plants will all generate incredible returns.Self-Driving State of Play: Chris, a former Tesla Autopilot lead, gives his read on Waymo's lead, Tesla's small Austin pilot, and why the real signal is when Tesla starts filing for fully autonomous permits in California. Learn more about Gecko Robotics: https://www.geckorobotics.com Learn more about Modular: https://www.modular.com/ This Week In AI is made possible by: *PayPalOpen* - One Platform for all Business: paypalopen.com *Timestamps:* 00:00 Welcome & intro to Jake Lu (Gecko Robotics) and Chris Lattner (Modular) 01:34 Gecko's 13-year journey & the Cantilever platform 05:15 Chris Lattner on Modular: replacing Cuda & unifying AI hardware 11:10 Nvidia lock-in, AMD's Rock & why the software stack is broken 19:49 The GPU shortage: how real is it? 22:13 Who challenges Nvidia? Google TPUs, Amazon Trainium & AMD ranked 28:17 China chip smuggling: $2.5B in Nvidia GPUs & the AI cold war 37:43 Self-driving update: Waymo, Tesla's Austin pilot & Chris's Tesla history 42:20 Figure's humanoid package sorting — real or demo magic? 43:47 The best decade for private equity in capital-intensive assets 51:04 Reindustrialization, the trades boom & making manufacturing cool 58:39 Building tech companies outside Silicon Valley 1:06:46 Breaking news: Brett Adcock launches Hark from Figure 1:10:15 Closing thoughts: grit over hype, customers over valuations Subscribe to This Week in AI on Apple: https://thisweekinai.ai/spotify Subscribe to This Week in AI on Spotify: https://thisweekinai.ai/apple Thanks for watching! 🤖 If you want to stay ahead of the curve on all things AI, make sure to join our community across all platforms: 📩 Get the Weekly Newsletter: https://thisweekinai.ai/ 📺 Subscribe on YouTube: https://www.youtube.com/@ThisWeekinAIPodcast 📸 Instagram: https://www.instagram.com/thisweekinaipodcast 📱 TikTok: https://www.tiktok.com/@thisweekinaipodcast ✖️X: https://x.com/ThisWeeknAI Follow Jason: X: https://twitter.com/Jason Follow Oliver: https://x.com/oliverkorzen