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Rating
4.6from
This podcast has
826 episodes
Language
EnglishPublisher
seriouspod.comExplicit
Yes
Date created
2014/01/21
Latest episode
2026/04/18
Average duration
68 min.
Release period
12 days
Description
Join Thomas for some critical thinking on questions of science, philosophy, skepticism and politics. These serious topics are discussed with some serious guests, but in an entertaining and engaging way! This is not your typical interview podcast; it's a friendly dialogue, conducted thoughtfully and with plenty of humor. It's Serious Inquiries Only; but like, not boring or anything.
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Check latest episodes from Serious Inquiries Only podcast
SIO511: What a Recent Chappell Roan Incident Teaches Us About Sexism
2026/04/18
Well, what do you know - it's a day that ends in y so the internet has a woman to hate. You might have seen some of the chatter about child-hating Chappell Roan lately, and it's just so depressing every single time one of these hate campaigns rears its ugly head. Lydia joins the show as resident Chappell Roan fan to discuss what actually happened, and why society so quickly jumps on these opportunities to hate women.
The Chappell Roan Harassment Campaign Is Plain Old Misogyny (Alex Nguyen - Mother Jones, 4/14/2026)
X profits from turning Chappell Roan into a viral villain (Kat Tenbarge, 3/30/2026)
Are you an expert in something and want to be on the show? Apply here!
SIO510: Digging Into the Science of the Placebo Effect
2026/04/12
Popular media will tell you that placebos, inert inactive substances taken as if they're medication, can work miracles. …Placebos don't "work". But what does that even mean? And if that's true, why would we include a placebo group in a study? Is there anything remotely like a "true"'placebo effect, where belief in a medication could influence the body? Jenessa walks us through scientific study design, statistical artifacts, and one study that shows maybe just maybe there's a little something like an actual placebo "effect"… but it's still not magic! Tune in to hear how on earth that could be possible.
Nolan, T.A., Price, D.D., Caudle, R., Murphy, N.P., & Neubert, J.K. (2012). Placebo-induced analgesia in an operant pain model in rats. Pain, 153, 2009-2016.
Brissonnet, J. (2015). Placebo, are you there? Science Based Medicine.
Studeman, D. (2007). But I regress… The Hardball Times.
McCambridge, J., de Bruin, M., & Witton, J. (2012). The effect of demand characteristics on research participant behaviours in non-laboratory settings: A systematic review. PLoS One, 7.
Are you an expert in something and want to be on the show? Apply here!
SIO509: What Project Hail Mary Gets Right (And Very Wrong...) About Biology
2026/04/04
Everyone's favorite biologist and dinosaur enthusiast Dr. Eric Jaffe is back! Project Hail Mary is a very fun, and quite good, sciency movie that is cleaning up at the box office right now. You should see it! Eric is going to take us through the biology of the movie (and book) and what it gets right, and what it gets quite wrong.
SIO508: The Data Shows That Authoritarianism Is Very Often Successfully Reversed. Yes, Really.
2026/03/31
"Yes we can" vote and protest our way out of authoritarianism.
It's a classic case of academic literature never making it to mainstream consumption. Hang around social media long enough and you'll hear that we're basically screwed. A complete fascist take over is either extremely likely, inevitable, or it's already here. And there's not much we can do about it. Unless some other country invades us, we'll be waiting for a civil war or a bloody military coup to hopefully maybe turn things around. That's what history teaches us, right?
Literally the opposite. An incredible data set that a team of thousands of academics have been assembling for over a decade provides a unique opportunity to examine these questions with fresh eyes. To look at wannabe dictators and see how many succeeded, how many eventually lost power, how democracy returned (if ever), and why. With this systematic approach, we see that strengthened democracy specifically because of authoritarian episodes is increasingly common. In fact, in the last 30 years it's the most common response to autocratization, and most often achieved by internal democratic actors. Taking this into account, events once viewed as episodes of successful stand-alone autocratization, with resistance ultimately futile, are actually better characterized as failures that caused a wave of democratic sentiment in the populace. Successful civil resistance that just took time.
Jenessa takes us through the paper that has her jumping for joy this week. Resist!
Nord, M. Angiolillo, F., Lundstedt, M., Wiebrecht, F., & Lindberg, S.I. (2025). When autocratization is reversed: episodes of U-Turns since 1900. Democratization, 32, 1136-1159.
Frequently asked questions. Varieties of Democracy Institute.
The Episodes of Regime Transformation (ERT) dataset. Varieties of Democracy Institute.
V-Dem. Electoral Democracy Index, 2024. Our World in Data.
Sato, Y., Lundstedt, M., Morrison, K., Boese, V.A., & Lindberg, S.I. (2022). Institutional order in episodes of autocratization. The Varieties of Democracy Institute.
Armitage, C. (Aug. 13, 2025). I researched every attempt to stop fascism in history. The success rate is 0%. The Existentialist Republic.
Further reading:
Nord, M., Angiolillo, F., Good God, A., & Lindberg, S.I. (2025). State of the world 2024: 25 years of autocratization – democracy trumped? Democratization, 32, 839-864.
Anti-Pluralism. European Center for Populism Studies.
Coppedge, M. (2023). V-Dem's conceptions of democracy and their consequences. The Varieties of Democracy Institute.
Lührmann, A. & Lindberg, S.I. (2019). A third wave of autocratization is here: What is new about it? Democratization, 26, 1095-1113.
Croissant, A. & Lott, L. (2025). Democratic resilience in the twenty-first century: Search for an analytical framework and explorative analysis. Political Studies, 0, 1-28.
Tomini, L., Gibril, S. & Bochev, V. (2023). Standing up against autocratization across political regimes: A comparative analysis of resistance actors and strategies. Democratization, 30, 119-138.
Wiebrecht, F., Sato, Y., Nord, M., Lundstedt, M., Angiolillo, F., & Lindberg, S.I. (2023). State of the world 2022: Defiance in the face of autocratization. Democratization, 30, 769-793.
Gamboa, L. (2017). Opposition at the margins: Strategies against the erosion of democracy in Colombia and Venezuela. Comparative Politics, 49, 457-477.
Laebens, M.G., & Lührmann, A. (2023). What halts democratic erosion? The changing role of accountability. In Lührmann, A. & Merkel, W. (Eds.), Resilience of democracy: Responses to illiberal and authoritarian challenges (pp. 40-61). Routledge.
Are you an expert in something and want to be on the show? Apply here!
SIO507: Shirley You're Joking, Minnesota Fraud Man!
2026/03/26
It's part 2 of the Minnesota fraud stuff. We get a little more Nick Shirley, dumbest person ever to testify in congress. And then I debunk the main claims against Gov. Walz and AG Ellison. Did Walz un-stop the payments to Feed Our Future? Did Ellison meet with, and then get campaign donations from the fraudsters?
SIO506: Minnesota Fraud and the Death of Information
2026/03/24
So now that we've covered a real hearing with brave whistleblowers that got NO attention, it's time to look at what happens over on the other side of the aisle.
SIO505: The ICE Whistleblower Hearing Was Astonishing. It Needs More Attention.
2026/03/15
Last month, there was a devastating hearing featuring a victim of ICE, an ICE whistleblower, and a previous DHS attorney. It revealed what, in any other time, would have been a massive scandal likely resulting in multiple firings. But we live in the bad times, which means this hearing took place in a maintenance shed barely on Congressional property during lunchtime put on by a ragtag team of the few remaining people who give a shit about constitutional rights. I take you through the hearing, and then next episode we're going to compare this to the Minnesota fraud hearings, of which the MAGA controlled congress has had... 3? 4? There is a marked difference in the seriousness of the people involved.
SIO504: The Other Kind of Nut Allergy. Well, Both Kinds, I Guess?
2026/03/15
Part 2! Even more fun Quibbies.
Allergies
Bansal, A.S., Chee, R., Nagendran, V., Warner, A., & Hayman, G. (2007). Dangerous liaison: Sexually transmitted allergic reaction to Brazil nuts. Journal of Investigational Allergology and Clinical Immunology, 17, 189-191.
Testosterone
University of Zurich (2009, December 9). Testosterone does not induce aggression, study shows. ScienceDaily.
Eisenegger, C., Naef, M., Snozzi, R., Heinrichs, M., & Fehr, E. (2010). Prejudice and truth about the effect of testosterone on human bargaining behavior. Nature, 463, 356-359.
ADHD and TikTok
Verma, S. & Sinha, S.K. (2024). How evidence-based is the "hashtag ADHD test" (#adhdtest). A cross-sectional content analysis of TikTok videos on attention-deficit/hyperactivity disorder (ADHD) screening. Australian Psychiatry, 0, 1-7.
Are you an expert in something and want to be on the show? Apply here!
SIO503: Viral Post Claims Texas Has More Democrats Than Republicans. Is That True?
2026/02/26
It's Quibi Time (tm) with Jenessa! (Don't worry, I'll explain...) It's 2 debunks for the price of 1, or actually 5 debunks for the price of 2, because this is a two-parter! Here are the first two:
AI girlfriend
Caramela, S. (2025, January 31). Most Men Would Marry Their AI Girlfriend if it were Legal. Vice.
Fiorillo, C. & Bartlett, S. (2025, January 28). AI girlfriends could be a thing of the future as men admit they would marry robot lovers. The Mirror.
Koetsier, J. (2025, April 29). 80% Of Gen Zers Would Marry An AI: Study. Forbes.
Mashable. (2025, May 22). Majority of Gen Z would marry an AI, survey says. Yahoo!Life.
(2025, May 11). GenZ Believes They Could Marry AI, Replace Human Connections: Report. NDTV World.
Ulanoff, L. (2025, May 22). Would you marry an AI? A recent survey says most Gen Z-ers would - here's why that's a ridiculous idea. Techradar.
Texas voter registration
(2025, August 7). Texas. Independent Voter Project. (Thomas saw this viral Reddit post about it)
Texas by the Numbers. L2.
January 2025 Voter Registration Figures. Texas Secretary of State.
Turnout and Voter Registration Figures (1970 - current). Texas Secretary of State.
Are you an expert in something and want to be on the show? Apply here!
This Is The Dark Place. Why Aren't We Acting Like It?
2026/01/27
I had a lot I needed to say about the ICE murders of Rene Good and Alex Pretti. And about the fascists who lie to our faces and know we can't do anything about it. And the concentration camps we already have. I did video because there was so much visual element to this, so watching would be best.
SIO501: What Pluribus Gets Right about Neuroscience
2026/01/07
Subject of much sci-fi media and philosophy discussions, the "hive mind" is also a key element of Vince Gilligan's (Breaking Bad, Better Call Saul) new show, Pluribus. Dr. Jenessa Seymour joins the pod to walk us through examples that we have studied of hive mind behavior (in the insect world), and why we can reasonably assert that you could not maintain your individuality if our brains directly communicated with each other (in the human world).
Wolman, D. (2012). A tale of two halves. Nature, 483, 260-263.
Split brain patient video demonstration
Wittlinger, M., Wehner, R., & Wolf, H. (2006). The ant odometer: Stepping on stilts and stumps. Science, 312, 1965-1967.
Penick, C.A. & Smith, A.A. (2015). The true odor of the odorous house ant. American Entomologist, 61, 85-87.
Are you an expert in something and want to be on the show? Apply here!
Please support the show on patreon! You get ad free episodes, early episodes, and other bonus content!
SIO500: A New Study Suggests Brain Imaging Might Have Significant Flaws
2026/01/01
Brain pics, or they didn't happen? There's a recent study that demonstrates that some brain region activity might interact differently with oxygen than previously assumed. This could upend significant neuroscience research spanning decades. Thankfully SIO has Dr. Jenessa Seymour to come in and break it all down for us!
We start with a primer on the science of neuroimaging tools and the images they produce. How in the WORLD can we get a picture of a brain while a person is still alive? What are the things we need to know when evaluating scholarly articles or popular media coverage about the brain that uses these brain "scans" in discussing their results? And what do we need to see next to support the findings of this study that could have incredible ramifications across our understanding of the brain?
Epp, S.M., Castrillón, G., Yuan, B. et al. BOLD signal changes can oppose oxygen metabolism across the human cortex. Nat Neurosci (2025).
Example structural MRI (sMRI) of a human brain
Güttler, F.V., Heinrich, A., Rump, J., de Bucourt, M., Schnackenburg, B., … Teichgräber, U.K. (2012). Magnetic resonance imaging of the active second stage of labour: Proof of principle. European Radiology, 22, 2020–2026
Diffusion Tensor Imaging (DTI) example image
Example functional MRI (fMRI)
Example fMRI with a more-appropriately blurry sMRI underneath
After Warping Options, Configurable Pipeline for the Analysis of Connectomes (0, 4, and 8mm filter images)
Jenessa's Brain:
Jenessa's brain sMRI
Are you an expert in something and want to be on the show? Apply here!
Please support the show on patreon! You get ad free episodes, early episodes, and other bonus content!
SIO499: Trump Is Weaponizing Government Against Political Enemies. Nick Fish, President of American Atheists, on How to Be Prepared
2025/12/02
In late September, shortly after declaring antifa a "domestic terrorist", Trump issued a memorandum directing the IRS to investigate tax-exempt organizations that could be "directly or indirectly financing political violence or domestic terrorism" and nonprofit organizations reasonably felt concerned of being targeted. A couple of weeks later, Lydia and Thomas ran into Nick Fish, President of the American Atheists, at California Freethought Day and asked how he and the organization were holding up in light of everything.
We're pleased to have Nick on to discuss what nonprofit organizations can do to protect themselves, as well as the people who have supported their mission and the communities they serve, when it is feeling less and less paranoid that the federal government might be coming for you. How can organizations fortify themselves through governing documents and organizational structure to donor databases and retention policies when the President of the United States could very well declare your nonprofit a supporter of domestic terrorism?
Countering Domestic Terrorism and Organized Political Violence (NSPM-7) (9/25/2025)
Support American Atheists!
SIO498: The Science of Hallucinations, Ear-worms, and Phantom Limbs
2025/11/26
Dr. Jenessa Seymour is on to teach us more about the brain! What do hallucinations, ear-worms, and phantom limbs have in common? And is "hallucinating" really a good term for what AI does when it makes something up?
SIO497: The Mamdani Machine Exposed! Part 2
2025/11/05
Part 2 of Asra Nomani's insanely terrible Fox News article. Make sure you listened to part 1!
This is big, folks. Think Watergate combined with Deflate-gate combined with Christina Applegate combined with the Bowling Green Massacre. THAT's how big of a scandal this is.
You thought Zohran Mamdani was just an innocent 34 year old assemblyman who rose to stardom by being an incredibly good candidate and relentless campaigning an economic message in a positive way. But you were an idiot. Dummy.
Asra Nomani broke it here, but let Jenessa and I explain it to you because clearly your feeble, gullible brain can't process. information properly.
Podcast reviews
Read Serious Inquiries Only podcast reviews
loving the podcast 2025/02/07
If you care about reality, listen to this podcast!
Thomas has always delivered sharp thoughtful analysis but his latest batch of episode since the election has been on fire! If you recognize what’s hap...
IcenineCC 2025/01/22
Great show
Thomas is awesome
Cat Mom 103 2024/11/09
Clarity
Thank you for your clarity, I appreciate you.
Talkahuano 2025/01/12
Please stop talking about Trump
I thought this podcast was for learning about jobs and cool sciency stuff. Why is it political now? Other podcasts from the same guy already do that. ...
OutdoorKatnip 2024/08/29
A fun way to learn a little bit about a lot
Thomas is one of my all-time favorite podcast hosts. Versatile, entertaining, and a great question asked. He knows right when to pop in with a humorou...
BG45 2024/10/12
Ads Only
How do you know it’s a Thomas Smith podcast? It has 4x the ads of any other podcast you listen to.
goodvsevil 2024/01/12
I politely disagree
We MIGHT live in a "simulation" of sorts; if it is computer based, it isnt like any kind of computer that we can imagine right now. And the simulated...
Agapic64 2024/08/01
Unserious
Not very serious. Name calling, poor grammar and spelling. Talking points mixed with poor research. Appeals to authority. Unfollowing.
izzybr 2024/01/31
Great podcast if you’re already of limited intellectual capacity
If you are more intelligent than a clever jellyfish, I’m not sure this podcast is for you. If you perhaps are an amoeba with fetal alcohol syndrome, t...
Grand Priapism 2023/11/08
Thomas makes everything better. Lydia "assists"
Thomas is the grease that makes the podcast go. He's the interested comedian or whatever they used to say on that other podcast. Lydia and Thomas are ...
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